CN104474039A - Honeysuckle, scutellaria baicalensis and white paeony root injection for treating cold of livestock and poultry and preparation method thereof - Google Patents
Honeysuckle, scutellaria baicalensis and white paeony root injection for treating cold of livestock and poultry and preparation method thereof Download PDFInfo
- Publication number
- CN104474039A CN104474039A CN201410663696.6A CN201410663696A CN104474039A CN 104474039 A CN104474039 A CN 104474039A CN 201410663696 A CN201410663696 A CN 201410663696A CN 104474039 A CN104474039 A CN 104474039A
- Authority
- CN
- China
- Prior art keywords
- parts
- injection
- poultry
- livestock
- cold
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses honeysuckle, scutellaria baicalensis and white paeony root injection for treating cold of livestock and poultry. The injection is characterized by being prepared from the following raw material medicines in parts by weight: 100-200 parts of honeysuckle, 50-100 parts of scutellaria baicalensis, 30-80 parts of white paeony root, 60-80 parts of astragalus, 50-80 parts of schizonepeta, 5-10 parts of Tween-80, 2-5 parts of sodium benzoate, 2-4 parts of sodium hydrogen sulfite, 0.2-0.5 part of ethylene diamine tetraacetic acid, 50-100 parts of propylene glycol and distilled water for injection. Multiple traditional Chinese medicines with the effects of clearing away heat and toxic materials, relieving muscular spasm, diminishing inflammation and improving the disease resistance of animal organisms are utilized, and a good effect of treating the cold of livestock and poultry is achieved by virtue of scientific compatibility by utilizing a synergistic effect generated among the medicines. The injection does not have drug residue or any toxic or side effect; and moreover, the resistance to drugs is avoided, particularly no residues are remained in the body after the injection is taken by egg laying poultry and meat poultry, and the edible safety on meat and eggs can be further effectively guaranteed.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of Animal diseases, especially a kind of golden a kind of reed mentioned in ancient books Chinese herbaceous peony injection for the treatment of livestock and poultry cold and preparation method thereof.
Background technology
Livestock and poultry cold is poultry commonly encountered diseases, one of frequently-occurring disease.Because climate change or feeding and management are not good at more than it, poultry body constitution is caused to decline, the invasion and attack of cold virus can not be resisted and occur, although the ratio that flu itself directly causes poultry death is less, flu can cause growth of animals or poultry to stagnate, become thin, and increases feeding cost, bring larger economic loss, in addition flu can cause poultry body constitution to decline, and finally causes other pathogen such as Diplococcus pneumoniae, pasteurellosis bacillus, Salmonella etc. to produce secondary infection, and makes poultry mortality.For solving this difficult problem, numerous veterinarys, veterinary drug worker have carried out a large amount of research work in this respect, but up to the present, there is no very good specific drug.At present, the Western medicine for the treatment of cold pig, be mostly directed toward bacteria sexually transmitted disease or complication and carry out, to virosis, then effect is bad, and price is also high.Meanwhile, long-term abuse of antibiotics, sulfonamides and some chemical drugss, after making antibacterial create drug resistance, dosage can increase widely and cause curative effect to decline.Not only increase feeding cost, also add antibiotic and the residual and toxic and side effects of chemical drugs in poultry body, bring serious harm to the health of the mankind.Although the Chinese herbal medicine of conventional dosage forms has longer research history, have many prescriptions to have certain effect to it, generally speaking, curative effect is not high, takes inconvenience, and healing time is longer.Industry is seeking the antiviral drugs of a kind of natural noresidue, determined curative effect always.
At present, countries in the world " back to nature ", " green consumption " become fashion, and natural drug becomes the primary selection of health care, and Chinese medicine also comes into one's own day by day in the impact of world's medical market and status.In countries and regions such as the Hong Kong, Macao and Taiwan of Europe, the United States, Japan and Korea S. and China, in (beast) medicine start to be admitted gradually.Current overseas in the feature of (beast) medicine development be: focus on curative effect with practicality, adopt modern formulation, curing the disease combines with health care.
Along with the development of our people's growth in the living standard and pollution-free food, domestic, international market is more and more higher to food safety requirements, the safety problem that animal products is produced also more and more is subject to people's attention, in the exploitation of (beast) medicine product more and more receive the concern of people.In (beast) medicine be natural plant product, having the feature of drug residue free, is first-selected green veterinary products.A large amount of scientific experiments proves, many Chinese herbal medicine not only itself have good antibacterial, antivirus action, more can the barrier defense function of enhancing body Organ and tissue, and the effect of this uniqueness meets the trend of current environmental protection.
The object of the present invention is to provide golden a kind of reed mentioned in ancient books Chinese herbaceous peony injection of a kind of determined curative effect, treatment livestock and poultry cold that is cheap, easy to use, that remain without hazardous drugs and preparation method thereof.Object of the present invention is realized by following technical proposals: the present invention has following bulk drugs by weight formulated; Flos Lonicerae 100-200, Radix Scutellariae 50-100, Radix Paeoniae Alba 30-80, Radix Astragali 60-80, Herba Schizonepetae 50-80, tween 80 5-10, sodium benzoate 2-5, sodium sulfite 2-4, disodiumedetate 0.2-0.5, propylene glycol 50-100 and distilled water for injection.
Preparation method of the present invention follows these steps to carry out;
Distillation: first by Flos Lonicerae, Herba Schizonepetae vapor distillation, collects distillate, and then redistillation again after adding distil water, gets rectification liquid, save backup in 4 DEG C;
Alcohol reflux: Flos Lonicerae, Herba Schizonepetae medicinal residues are mixed with Radix Scutellariae, the Radix Astragali, the Radix Paeoniae Alba, adds 10 times amount 70% ethanol, reflux, extract, 2 times, each 1 hour, merge extractive liquid, places 48 hours for 4 DEG C, filters, filtrate reduced in volume, then add ethanol in proper amount precipitate with ethanol, make alcohol content reach 90%, place 48 hours for 4 DEG C, filter, filtrate reduced in volume is extremely without alcohol taste; Inject with water, adjust ph, to 5.5-6.5, adds concentrated solution 0.5% active carbon, leaves standstill to room temperature after boiling, and filters, filtrate cold preservation 24 hours;
Mixing, subpackage, sterilizing; Filtered by the cold preservation liquid of second step, filtrate adds rectification liquid and sodium benzoate, tween 80, disodiumedetate, the propylene glycol of the first step, and injects water to 1000ml, stirs, and filter, embedding, sterilizing, to obtain final product.
The primary efficacy of Chinese medicine in the present invention:
Flos Lonicerae: cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat effect of wind, cures mainly disease under distension, epidemic febrile disease heating, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.It is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy has certain curative effect, Flos Lonicerae containing cyclohexanhexanol, flavonoid, inositol, Saponin and tannin etc., there is broad-spectrum antibacterial action, all there is stronger inhibitory action to the various pathogens such as staphylococcus aureus, dysentery bacterium, also have inhibitory action to multiple pathogenic microorganisms such as leptospira, influenza virus and pathogenic moulds.In addition, Flos Lonicerae also has obvious antiinflammatory and refrigeration function.Recently research is pointed out, Flos Lonicerae can promote lymphocytic conversion, and lymhocyte transformation rate can reflect cellular immune function, namely improves immunity of organisms.Flos Lonicerae can also strengthen leukocytic phagocytic function, improves immunologic function from another angle; The diseases such as enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.
Radix Scutellariae: bitter in the mouth, cold in nature, has heat clearing and damp drying, eliminating fire and detoxication, hemostasis, the effect such as antiabortive.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical antibiotic property of Radix Scutellariae is better than Rhizoma Coptidis, and does not develop immunity to drugs.
Radix Paeoniae: there is spasmolytic, ease pain, the effect of stimulating the menstrual flow.Effective to diseases such as the stomachache of women, stomach spasm, dizzy, gout, diuresis.
The Radix Astragali: tool tonifying Qi and lifting yang, benefiting QI for strengthening the superficies, inducing diuresis to remove edema, detoxification, granulation promoting effect, is applicable to spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle and does not burst or burst and the disease such as not hold back for a long time.
Herba Schizonepetae: acrid in the mouth; Micro-hardship; Slightly warm in nature.Tool dispels the wind, induce sweat, rash, hemostasis.Main cold, fever, headache, eye itching, cough, laryngopharynx swelling and pain, measles, carbuncle, skin ulcer scabies, epistaxis, spit blood, have blood in stool, metrorrhagia, puerperal blood faints.For flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.Induce sweat loose wind, rash, and disappear skin ulcer, hemostasis.For flu, measles is sent out smooth thoroughly, have blood in stool, metrorrhagia, epistaxis.
In addition for ensureing that injectable drug is stable and promoting that animal body is to drug absorption, the present invention is also added with solubilizing agent, anticorrosion and antioxidant etc.
The present invention utilize multiple tool heat-clearing and toxic substances removing, spasmolytic, antiinflammatory and improve animal body resistance against diseases Chinese medicine, by scientific compatibility, utilize the synergism produced between each medicine, achieve the effect for the treatment of livestock and poultry cold preferably.No drug residue of the present invention, to have no side effect; Can not develop immunity to drugs, particularly egg-laying bird, poultry take noresidue in rear body, and then effectively can ensure the edible safety problem of people to meat egg.
The animal test of pesticide effectiveness
In December, 2013, pig farm, Leshan sichuan has 69 body weight to occur that rhinorrhea, sneeze, slight cough, spirit are depressed the market pig of about 50kg altogether, and the symptoms such as loss of appetite, part pig body temperature raises.Be that temperature changes suddenly and causes swinery to catch a cold through Disease Diagnosis of Veterinary, be now divided into 4 groups to treat at random these 69 market pigs, adopt the test of intramuscular injection this product, injection of Radix Bupleuri, gentamicin injection liquid, injection benzylpenicillin potassium to treat respectively.
Comparison of test results: the cure rate of application reagent treatment cold pig is 88.9%, the cure rate of application injection of Radix Bupleuri treatment cold pig is 64.7%, the cure rate of using sulfated injection liquid of gentamicin treatment cold pig is 76.5%, the cure rate of application injection benzylpenicillin potassium treatment cold pig is 82.3%, reagent therapeutic effect is obviously better than injection of Radix Bupleuri, gentamicin injection liquid, injection benzylpenicillin potassium, and relapse rate is only 6.25%.
Using method: intramuscular injection, 0.2ml/kg body weight, 1 time on the one, is used in conjunction 3 times.
Detailed description of the invention
Embodiment 1:
A kind of golden a kind of reed mentioned in ancient books Chinese herbaceous peony injection for the treatment of livestock and poultry cold and preparation method thereof, follows these steps to carry out;
1, distillation extraction: Flos Lonicerae 10.0kg, Herba Schizonepetae 8.0kg are put in multi-function extractor, add 1 times amount water for injection and soak half an hour, then add 8 times amount waters for injection and carry out vapor distillation extraction, after collecting first distillate, carry out redistillation again, collect re-distilled liquid, for subsequent use.
2, alcohol reflux: get Radix Scutellariae 10.0kg, Radix Paeoniae Alba 8.0kg, Radix Astragali 6.0kg, Flos Lonicerae and Herba Schizonepetae bottoms (producer: Yongtai Pharmaceutical Chemical Industry Machinery Factory, Chengdu in multi-functional extraction concentration and recovery unit; Model: TNG-500), add the ethanol of 10 times amount 70% respectively, carry out reflux, extract, 2 times, each 1 hour, merge extractive liquid, places 48 hours for 4 DEG C, filters, filtrate reduced in volume, then add ethanol, make alcohol content reach 90%, place 48 hours for 4 DEG C, filter, filtrate reduced in volume, to without alcohol taste, injects water to about 60kg, and adjust ph is to about 5.5-6.5, add 0.5% active carbon, leave standstill to room temperature after boiling, filter, filtrate cold preservation 24 hours, filters, for subsequent use.
3, mixing, subpackage, sterilizing: by 1,2 steps obtain liquid and merge, and add sodium benzoate 0.5Kg, sodium sulfite 0.2Kg, tween 80 1kg, disodiumedetate 0.02kg, propylene glycol 5kg inject water to 100kg, stir, filter, embedding, sterilizing, to obtain final product.
Embodiment 2:
A kind of golden a kind of reed mentioned in ancient books Chinese herbaceous peony injection for the treatment of livestock and poultry cold and preparation method thereof, follows these steps to carry out;
1, distillation extraction: Flos Lonicerae 15.0kg, Herba Schizonepetae 7kg are put in multi-function extractor, add 1 times amount water for injection and soak half an hour, then add 8 times amount waters for injection and carry out vapor distillation extraction, after collecting first distillate, carry out redistillation again, collect re-distilled liquid, for subsequent use.
2, alcohol reflux: get Radix Scutellariae 8.0kg, Radix Paeoniae Alba 5.0kg, Radix Astragali 7kg Flos Lonicerae bottoms are in multi-functional extraction concentration and recovery unit, add the ethanol of 10 times amount 70% respectively, carry out reflux, extract, 2 times, each 1 hour, merge extractive liquid, place 48 hours for 4 DEG C, filter, filtrate reduced in volume, then ethanol is added, alcohol content is made to reach 90%, place 48 hours for 4 DEG C, filter, filtrate reduced in volume is extremely without alcohol taste, inject water to about 60kg, adjust ph is to about 5.5-6.5, add 0.5% active carbon, leave standstill after boiling to room temperature, filter, filtrate cold preservation 24 hours, filter, for subsequent use.
3, mixing, subpackage, sterilizing: by 1,2 steps obtain liquid and merge, and add sodium benzoate 0.5Kg, sodium sulfite 0.4Kg, tween 80 0.5kg, disodiumedetate 0.05kg, propylene glycol 10kg, and inject water to 100kg, stir, filter, embedding, sterilizing, to obtain final product.
Embodiment 3:
A kind of golden a kind of reed mentioned in ancient books Chinese herbaceous peony injection for the treatment of livestock and poultry cold and preparation method thereof, follows these steps to carry out;
1, distillation extraction: Flos Lonicerae 20.0kg, Herba Schizonepetae 6kg are put in multi-function extractor, add 1 times amount water for injection and soak half an hour, then add 8 times amount waters for injection and carry out vapor distillation extraction, after collecting first distillate, carry out redistillation again, collect re-distilled liquid, for subsequent use.
2, alcohol reflux: get Radix Scutellariae 5.0kg, Radix Paeoniae Alba 3.0kg, Radix Astragali 8kg Flos Lonicerae bottoms are in multi-functional extraction concentration and recovery unit, add the ethanol of 10 times amount 70% respectively, carry out reflux, extract, 2 times, each 1 hour, merge extractive liquid, place 48 hours for 4 DEG C, filter, filtrate reduced in volume, then ethanol is added, alcohol content is made to reach 90%, place 48 hours for 4 DEG C, filter, filtrate reduced in volume is extremely without alcohol taste, inject water to about 60kg, adjust ph is to about 5.5-6.5, add 0.5% active carbon, leave standstill after boiling to room temperature, filter, filtrate cold preservation 24 hours, filter, for subsequent use.
3, mixing, subpackage, sterilizing: by 2,3 steps obtain liquid and merge, and add sodium benzoate 1Kg, sodium sulfite 0.3Kg, tween 80 1kg, disodiumedetate 0.05kg, propylene glycol 10kg, and inject water to 100kg, stir, filter, embedding, sterilizing, to obtain final product.
Claims (2)
1. treat golden a kind of reed mentioned in ancient books Chinese herbaceous peony injection of livestock and poultry cold, it is characterized in that: by following bulk drugs by weight formulated; Flos Lonicerae 100-200, Radix Scutellariae 50-100, Radix Paeoniae Alba 30-80, Radix Astragali 60-80, Herba Schizonepetae 50-80, tween 80 5-10, sodium benzoate 2-5, sodium sulfite 2-4, disodiumedetate 0.2-0.5, propylene glycol 50-100 and distilled water for injection.
2. golden a kind of reed mentioned in ancient books Chinese herbaceous peony injection and preparation method thereof of a treatment livestock and poultry cold according to claim 1, is characterized in that: follow these steps to carry out
(1) distill: first by Flos Lonicerae, Herba Schizonepetae vapor distillation, to collect after distillate adding distil water redistillation again, get rectification liquid, save backup in 4 DEG C;
(2) alcohol reflux: Flos Lonicerae, Herba Schizonepetae medicinal residues are mixed with Radix Scutellariae, the Radix Astragali, the Radix Paeoniae Alba, add 10 times amount 70% ethanol, reflux, extract, 2 times, each 1 hour, merge extractive liquid, place 48 hours for 4 DEG C, filter, filtrate reduced in volume, precipitate with ethanol, alcohol content is made to reach 90%, place 48 hours for 4 DEG C, filter, filtrate reduced in volume is extremely without alcohol taste; Inject with water, adjust ph, to 5.5-6.5, adds concentrated solution 0.5% active carbon, leaves standstill to room temperature after boiling, and filters, filtrate cold preservation 24 hours;
(3) mixing, subpackage, sterilizing; Filtered by the cold preservation liquid of second step, filtrate adds rectification liquid and sodium benzoate, tween 80, disodiumedetate, the propylene glycol of the first step, and injects water to 1000ml, stirs, and filter, embedding, sterilizing, to obtain final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410663696.6A CN104474039A (en) | 2014-11-20 | 2014-11-20 | Honeysuckle, scutellaria baicalensis and white paeony root injection for treating cold of livestock and poultry and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410663696.6A CN104474039A (en) | 2014-11-20 | 2014-11-20 | Honeysuckle, scutellaria baicalensis and white paeony root injection for treating cold of livestock and poultry and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104474039A true CN104474039A (en) | 2015-04-01 |
Family
ID=52748740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410663696.6A Pending CN104474039A (en) | 2014-11-20 | 2014-11-20 | Honeysuckle, scutellaria baicalensis and white paeony root injection for treating cold of livestock and poultry and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104474039A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111529577A (en) * | 2020-03-31 | 2020-08-14 | 四川金坤动物药业有限公司 | Jinqin Shao injection and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068492A (en) * | 2011-01-05 | 2011-05-25 | 湖南时代阳光药业股份有限公司 | Anti-virus Chinese herbal medicine composition, traditional Chinese medicine composition and preparation method thereof |
-
2014
- 2014-11-20 CN CN201410663696.6A patent/CN104474039A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068492A (en) * | 2011-01-05 | 2011-05-25 | 湖南时代阳光药业股份有限公司 | Anti-virus Chinese herbal medicine composition, traditional Chinese medicine composition and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 农业部兽药评审中心: "《兽药国家标准汇编-兽药地方标准上升国家标准》", 31 July 2012, 中国农业出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111529577A (en) * | 2020-03-31 | 2020-08-14 | 四川金坤动物药业有限公司 | Jinqin Shao injection and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103961418B (en) | A kind of Chinese medicine microecological preparation and preparation method of preventing and treating infectious bursal disease | |
| CN102845638A (en) | Duck feed capable of preventing and treating avian influenza and Chinese herbal additive used therein | |
| CN111067974A (en) | Chinese herbal medicine preparation for preventing African swine fever virus and preparation method thereof | |
| CN102872392B (en) | Chinese medicinal preparation for preventing and controlling swine mycoplasma pneumonia and preparation method thereof | |
| CN106135730A (en) | A kind of antibacterial bacteriostatic livestock fodder additives | |
| CN103463225A (en) | Traditional Chinese medicine micro-ecologic preparation for preventing and treating newcastle disease and preparation method thereof | |
| CN102210813A (en) | Traditional Chinese medicine composition for diminishing inflammation and relieving toxicity for livestock and poultry and preparation method thereof | |
| CN101940651B (en) | Traditional Chinese medicine superfine powder for preventing and treating chicken colibacillosis and preparation method thereof | |
| CN102552653A (en) | Traditional Chinese medicinal composition with phlegm reducing and cough relieving functions and preparation method thereof | |
| CN104474039A (en) | Honeysuckle, scutellaria baicalensis and white paeony root injection for treating cold of livestock and poultry and preparation method thereof | |
| CN104971132A (en) | Traditional Chinese medicine preparation for preventing and treating skin ulcer disease of octopus variabilis | |
| CN101757136A (en) | Traditional Chinese medicine composite for treating viral swine high fever | |
| CN101390965A (en) | Veterinary traditional Chinese herb medicine for treating livestock and poultry bacterial and viral infectious diseases and preparation method thereof | |
| CN103142702A (en) | Chinese herbal medicine injection liquid for treating porcine reproductive and respiratory syndrome and preparation method thereof | |
| CN102771600A (en) | Isatis root tea-substituted beverage for preventing and treating influenza | |
| CN104840591A (en) | Traditional Chinese medicine composition with effect of preventing and treating Newcastle disease | |
| CN111068039A (en) | Poultry drinking water additive composition for preventing and treating viral diseases of livestock and poultry | |
| CN105663346A (en) | Granules for treating viral diseases in poultry and preparation method of granules | |
| CN105454550A (en) | Chinese olive lung clearing and throat moistening tea and production method thereof | |
| CN102793869A (en) | Traditional Chinese medicine composition for controlling porcine viral diseases and preparation method thereof | |
| CN104208168B (en) | A kind of for compound traditional Chinese medicine composite treating poultry respiratory infection and preparation method thereof | |
| CN107213384A (en) | A kind of composition for preventing and treating rabbit pest | |
| CN105012564A (en) | Spray preparation for treating quail diseases | |
| CN105395807A (en) | Traditional Chinese medicine composition and granules for preventing and curing swine streptococcosis and preparation method thereof | |
| CN106361902A (en) | Traditional Chinese medicine composition for preventing and treating livestock diarrhea and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150401 |
|
| WD01 | Invention patent application deemed withdrawn after publication |