CN105920268B - Traditional Chinese medicine composition for treating necrotic enteritis of chicken and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating necrotic enteritis of chicken and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating necrotic enteritis of chickens, which is mainly prepared from phellodendron, bitter orange, magnolia obavata, combined spicebush root, areca peel, bighead atractylodes rhizome, poria cocos, Chinese yam, hawthorn, sophora flavescens, medicated leaven, divaricate saposhnikovia root, dahurian patrinia herb, Chinese pulsatilla root, tree peony bark, selfheal, liquorice, nauclea officinalis, purple perilla, cassia occidentalis, astragalus, pomegranate bark, monkshood, dandelion, bunge corydalis herb, Chinese tallow tree and scutellaria baicalensis; a preparation method of a Chinese medicinal composition for treating necrotic enteritis in chicken comprises micronizing, mixing in batches, extracting, mixing, and concentrating. The traditional Chinese medicine composition disclosed by the invention has the advantages of obvious curative effect, no drug resistance and no drug residue, and can be used for treating necrotic enteritis of chickens, improving the internal environment of intestinal tracts of the chickens, improving the immunity of the chickens and the like.
Description
Technical Field
The invention relates to the technical field of veterinary drugs. More specifically, the invention relates to a traditional Chinese medicine composition for treating necrotic enteritis in chicken and a preparation method thereof.
Background
Necrotic enteritis is a bacterial infectious disease caused by clostridium welchii (also known as clostridium perfringens) type a or type C. The bacterium is a conditioned pathogen, and is carried by healthy chickens. The disease can be induced by bad ventilation of chicken houses, wet ground or by feeding mildewed and deteriorated fish meal and bean pulp. The disease mainly harms chickens of 2-5 weeks old, is characterized by small intestinal mucosa necrosis, has a death rate of 50 percent, and is extremely harmful.
At present, various antibacterial drugs such as penicillin, terramycin, ciprofloxacin and the like are most commonly used for treating the disease; due to the long-term repeated use of the antibacterial drugs, the pathogenic microorganisms generate drug resistance to the drugs, the curative effect is reduced, drug residues are generated in the chicken bodies, and the food safety is influenced.
Disclosure of Invention
An object of the present invention is to solve at least the above problems and to provide at least the advantages described later.
The invention also aims to provide the traditional Chinese medicine composition for treating the necrotic enteritis in the chicken, the composition is a pure traditional Chinese medicine preparation, has an obvious curative effect on the necrotic enteritis in the chicken, does not generate drug resistance and drug residue, can improve the intestinal environment of the chicken and improve the immunity of the chicken while treating the necrotic enteritis in the chicken.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition for treating chicken necrotic enteritis.
In order to achieve these objects and other advantages according to the present invention, there is provided a Chinese medicinal composition for treating necrotic enteritis in chicken, which is characterized by being prepared from the following raw materials in parts by weight: 15-25 parts of phellodendron, 25-35 parts of fructus aurantii, 25-35 parts of cortex magnoliae officinalis, 25-35 parts of radix linderae, 25-35 parts of pericarpium arecae, 40-60 parts of bighead atractylodes rhizome, 25-35 parts of poria cocos, 25-35 parts of Chinese yam, 25-35 parts of hawthorn, 15-25 parts of radix sophorae flavescentis, 25-35 parts of medicated leaven, 15-25 parts of divaricate saposhnikovia root, 25-35 parts of dahurian patrinia herb, 25-35 parts of Chinese pulsatilla root, 25-35 parts of tree peony bark, 25-35 parts of selfheal, 8-12 parts of liquorice, 25-35 parts of lignum naucleae officinalis, 25-35 parts of purple perilla, 25-35 parts of cassia occidentalis, 35-50 parts of astragalus root, 30-40 parts of pomegranate rind, 40-60 parts of monkshood, 40-60 parts of dandelion, 40-60 parts of bunge.
Preferably, the traditional Chinese medicine composition for treating necrotic enteritis of chickens is mainly prepared from the following raw materials in parts by weight: 20 parts of phellodendron, 30 parts of fructus aurantii, 30 parts of cortex magnoliae officinalis, 30 parts of combined spicebush root, 30 parts of pericarpium arecae, 50 parts of bighead atractylodes rhizome, 30 parts of poria cocos, 30 parts of Chinese yam, 30 parts of hawthorn, 20 parts of radix sophorae flavescentis, 30 parts of medicated leaven, 20 parts of divaricate saposhnikovia root, 30 parts of herba patriniae, 30 parts of Chinese pulsatilla root, 30 parts of tree peony bark, 30 parts of selfheal, 10 parts of liquorice, 30 parts of biliary tree, 30 parts of purple perilla, 30 parts of cassia occidentalis, 43 parts of astragalus mongholicus, 35 parts of pomegranate rind, 50 parts of monkshood, 50 parts of dandelion, 50 parts.
A preparation method of a traditional Chinese medicine composition for treating necrotic enteritis of chickens comprises the following steps:
step one, after each component in the formula is respectively cleaned and selected, the components are subjected to superfine grinding to 500-mesh and 600-mesh;
weighing the phellodendron, the sophora flavescens, the patrinia, the Chinese pulsatilla root, the tree peony bark, the selfheal, the nauclea officinalis, the dandelion, the bunge corydalis herb and the scutellaria baicalensis in parts by weight, and fully and uniformly mixing to obtain first mixed powder; weighing the lindera aggregate, the divaricate saposhnikovia root, the liquorice, the purple perilla, the pomegranate bark, the monkshood and the Chinese tallow tree in parts by weight, and fully and uniformly mixing to obtain second mixed powder; weighing the bitter orange, the magnolia obavata, the areca peel, the bighead atractylodes rhizome, the hawthorn, the poria cocos, the Chinese yam, the astragalus mongholicus, the medicated leaven and the cassia occidentalis in parts by weight, and fully mixing to obtain third mixed powder;
step three, carrying out reflux extraction on the first mixed powder for 2-3 times by using ethanol with the volume fraction of 70-80% to obtain a first extracting solution, carrying out reduced pressure concentration on the first extracting solution until the volume fraction of the ethanol is 30-40% to obtain a distillate and a concentrated solution, and carrying out reflux extraction on the concentrated solution for 2-3 times to obtain a second extracting solution;
step four, carrying out reflux extraction on the second mixed powder for 2-3 times by using the distillate to obtain a third extracting solution;
step five, carrying out reflux extraction on the third mixed powder for 2-3 times by using water to obtain a fourth extracting solution;
and step six, combining the second extracting solution, the third extracting solution and the fourth extracting solution, decocting at 95-98 ℃ for 3-5h, and concentrating under reduced pressure until the relative density is 1.25-1.30 to obtain the traditional Chinese medicine composition for treating the necrotic enteritis of the chickens.
Preferably, in the step three, the mass ratio of the ethanol with the volume fraction of 70-80% to the first mixed powder is 15-20: 1.
Preferably, in the fifth step, the mass ratio of the water to the third mixed powder is 10-15:1, the reflux extraction temperature is 50-60 ℃, and the reflux extraction time is 1-2 hours each time.
Preferably, in the third step and the fourth step, the temperature of the reflux extraction is 70-80 ℃, and the time of each reflux extraction is 0.5-1 h.
Preferably, the preparation method of the traditional Chinese medicine composition for treating necrotic enteritis in chicken is characterized in that in the sixth step, 30-50 parts by weight of cyclodextrin is added before the reduced pressure concentration, and the mixture is uniformly mixed.
The traditional Chinese medicine composition disclosed by the invention has the following medicine characteristics of the components:
phellodendron bark: bitter and cold, entering kidney, bladder and large intestine channels, has the effects of clearing heat and detoxicating, purging pathogenic fire and eliminating dampness, and is mainly used for treating acute bacillary dysentery, acute enteritis, acute icteric hepatitis, urinary system infection and other inflammations;
fructus aurantii: bitter, pungent, sour and warm, has the effects of regulating qi-flowing, relieving epigastric distention, activating stagnancy and relieving flatulence, and is mainly used for treating diseases such as qi stagnation in chest and hypochondrium, fullness and pain, indigestion, phlegm and fluid retention and the like;
chuanpu: bitter, pungent and warm, has effects of activating qi-flowing, resolving food stagnation, eliminating dampness, relieving fullness, lowering adverse qi, and relieving asthma, and can be used for treating food stagnation, qi stagnation, abdominal distention, constipation, damp obstruction of middle warmer, fullness in chest, asthma, and cough;
combined spicebush root: pungent and warm in property, enter stomach and kidney meridians, and have the actions of moving qi and alleviating pain, warming kidney and dispelling cold.
Pericarpium arecae: pungent and warm; it has effects of invigorating spleen, stomach, large intestine and small intestine channels, descending qi, relieving epigastric distention, promoting diuresis and relieving swelling, and can be used for treating damp obstruction, qi stagnation, chest and abdomen distention, constipation, edema, loempe, dysuria;
white atractylodes rhizome: bitter, sweet and warm, and has effects of invigorating spleen and replenishing qi, eliminating dampness and promoting diuresis, arresting sweating, and preventing miscarriage, and can be used for treating spleen deficiency and anorexia, abdominal distention and diarrhea, phlegm and fluid retention and dizziness, edema, spontaneous perspiration, and threatened abortion;
tuckahoe, poria cocos: sweet and neutral, enter heart, lung and spleen channels, have the effects of excreting dampness and promoting diuresis, strengthening spleen and stomach, calming heart and tranquilizing mind, and are mainly used for treating symptoms such as dysuresia, edema and fullness, phlegm and fluid retention and cough, vomiting, pernicious vomiting, diarrhea, spermatorrhea, stranguria with turbid urine, palpitation with fear, amnesia and the like;
chinese yam: sweet and neutral, enter spleen, lung and kidney channels, have the efficacies of tonifying spleen and nourishing stomach, promoting fluid production and benefiting lung, and tonifying kidney and arresting seminal emission, and are mainly used for treating spleen deficiency and anorexia, chronic diarrhea, lung deficiency and cough, kidney deficiency and spermatorrhea, leukorrhagia, frequent micturition, deficiency heat and thirst quenching;
hawthorn fruit: sour and warm, has the effects of qi and blood circulation, blood stasis without damaging new blood, qi stagnation without damaging healthy qi, and can be used for treating dyspepsia, diarrhea and dysentery, abdominal pain, hernia pain, stasis abdominal pain, chest pain, lochiorrhea, dysmenorrhea, hematemesis, hematochezia, etc.;
flavescent sophora root: bitter and cold in nature, entering liver, kidney, large intestine, small intestine, bladder, heart and bladder meridians, has effects of clearing heat, eliminating dampness, dispelling pathogenic wind and killing parasites, and is mainly used for treating damp-heat dysentery, intestinal wind, hematochezia, jaundice, dysuresia, edema, leukorrhagia, pudendal pruritus, mange tinea, leprosy, skin pruritus and pyocutaneous disease;
medicated leaven: bitter and warm, enter spleen, stomach and large intestine channels, have the effects of invigorating spleen to promote digestion, regulating qi-flowing for eliminating dampness, relieving exterior syndrome, and can be used for treating dyspepsia, abdominal pain, emesis, diarrhea, dysentery, common cold, headache, infantile hunger and satiety;
wind prevention: pungent, sweet and slightly warm, enter bladder, liver and spleen channels, have the efficacies of dispelling wind and relieving exterior syndrome, eliminating dampness and relieving pain, and relieving spasm and convulsion, and are mainly used for treating exogenous exterior syndrome, rubella and pruritus, rheumatic arthralgia and tetanus;
herba Patriniae: pungent, bitter and slightly cold, entering liver, stomach and large intestine channels, has effects of clearing heat and detoxicating, cooling blood, resolving carbuncle, discharging pus, removing blood stasis and relieving pain, and can be used for treating intestinal carbuncle, lung carbuncle hyperpyrexia, cough, empyema, heat toxin sore, furuncle, pain in chest and abdomen, appendicitis, enteritis, dysentery, puerperal abdominal pain, and dysmenorrhea;
the Chinese pulsatilla root: bitter and cold, entering stomach and large intestine channels, has the effects of clearing heat and detoxicating, cooling blood and stopping dysentery, eliminating dampness and killing parasites, and is mainly used for treating heat-toxin dysentery, epistaxis, blood hemorrhoid, leukorrhagia, pruritus vulvae, carbuncle sore and scrofula;
moutan bark: bitter, pungent and slightly cold, enter heart, liver and kidney channels, have the effects of clearing heat and cooling blood, promoting blood circulation and removing blood stasis, and are mainly used for treating warm diseases with heat entering blood system, macula, epistaxis, fever in later stage of the heat syndrome with yin deficiency, bone steaming and tidal fever, blood stagnation, amenorrhea, dysmenorrhea, carbuncle swelling and sore toxin, traumatic injury pain and rheumatism heat arthralgia;
selfheal: bitter, pungent and cold herbs enter liver and gallbladder meridians, have the effects of clearing liver fire, resolving hard mass, relieving swelling, clearing away heat and toxic materials, eliminating phlegm, relieving cough, cooling blood, and stopping bleeding, and can be used for treating lymphoid tuberculosis, goiter, acute mastitis, dizziness, facial distortion, bone and muscle pain, pulmonary tuberculosis, metrorrhagia, leukorrhagia, acute infectious icterohepatitis, bacillary dysentery, etc.;
licorice root: sweet and neutral, and has the effects of invigorating qi, strengthening the middle warmer, relieving spasm and pain, moistening lung, arresting cough, purging pathogenic fire, removing toxic substance, and harmonizing the drugs. Is mainly used for treating weakness of spleen and stomach, lassitude and hypodynamia, palpitation and shortness of breath, cough and excessive phlegm, abdominal cavity, limb spasm and pain, carbuncle and sore toxin, and relieving drug toxicity and pungency;
wood liner: bitter and cold, has effects of clearing heat and detoxicating, and relieving swelling and pain, and can be used for treating common cold fever, acute tonsillitis, pharyngolaryngitis, bronchitis, pneumonia, urinary system infection, enteritis, dysentery, and cholecystitis;
purple perilla: pungent and warm, has effects of dispelling cold, relieving exterior syndrome, regulating qi-flowing, and relieving epigastric distention, and can be used for treating wind-cold type common cold, headache, cough, and fullness and distention of chest and abdomen;
and (3) cassia seed: bitter, sweet, salty and slightly cold, enters liver, kidney and large intestine channels, has the effects of relaxing bowel, reducing fat and improving eyesight, and is mainly used for treating constipation, hyperlipidemia and hypertension;
astragalus root: sweet and warm, enter lung and spleen channels, have the efficacies of invigorating qi, consolidating exterior, promoting urination, expelling pus, healing sore and promoting granulation, and are mainly used for treating qi deficiency and hypodynamia, anorexia and loose stool, sinking of middle-jiao energy, chronic diarrhea and rectocele, hematochezia and metrorrhagia, exterior deficiency and spontaneous perspiration, qi deficiency and edema, carbuncle, cellulitis and ulceration difficulty, ulceration failure and astringency, blood deficiency and flaccidity and jaundice, internal heat and thirst, chronic nephritis proteinuria and diabetes;
pomegranate rind: sour, astringent and warm, enter large intestine meridian, have effects of relieving diarrhea with astringents, stopping bleeding and expelling parasites, and are mainly used for treating chronic diarrhea, chronic dysentery, hematochezia, rectocele, metrorrhagia, leucorrhea, abdominal pain due to parasitic accumulation;
monkshood: sweet and hot, enter heart, spleen and kidney meridians, have the effects of restoring yang and relieving the adverse rise of qi, tonifying fire and yang, dispelling cold and removing dampness, and are mainly used for treating exuberant yin and checking yang, apocrine sweat and yang, vomiting and syncope, psychroalgia of heart and abdomen, diarrhea and dysentery of spleen, beriberi edema and chronic infantile convulsion, arthralgia due to wind-cold-dampness, gangrene and ulcer leakage and all diseases of cold pertinence;
dandelion: bitter, sweet and cold, entering liver and stomach meridians, has the effects of clearing away heat and toxic materials, relieving swelling, resolving hard mass, inducing diuresis and treating stranguria. It can be used for treating furuncle, swelling, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, pulmonary abscess, intestinal abscess, jaundice due to damp-heat pathogen, and stranguria with damp-heat pathogen;
corydalis Bungeana (L.) Merr: bitter, pungent and cold, has the effects of clearing heat and removing toxicity, and is mainly used for treating furuncle, carbuncle and swelling, acute appendicitis and all purulent inflammations;
chinese tallow tree: bitter and cold, and has the effects of purging and removing water, dissipating blood stasis and relieving swelling.
Scutellaria baicalensis: bitter and cold, enter lung, gallbladder, spleen, large intestine and small intestine channels, have the effects of clearing heat and drying dampness, purging fire and removing toxicity, stopping bleeding and preventing miscarriage, and are mainly used for treating damp-warm disease, summer-warm disease, chest distress and nausea, damp-heat fullness and diarrhea, jaundice, lung-heat cough, high fever and polydipsia, blood heat and hematemesis, carbuncle swelling and sore toxicity and threatened abortion.
The invention at least comprises the following beneficial effects:
the traditional Chinese medicine composition is prepared by scientifically mixing the traditional Chinese medicines according to the guidance of the theory of the traditional Chinese medicine and by adopting a modern pharmaceutical means, has the characteristics of obvious curative effect, no drug resistance, no drug residue and the like, can improve the internal environment of intestinal tracts of chickens and improve the immunity of the chickens, and is a green nuisanceless veterinary medicine;
secondly, the traditional Chinese medicine composition is a pure traditional Chinese medicine preparation, takes heat clearing, detoxifying, dampness removing and cold dispelling as basic treatment rules, has the effects of tonifying qi, nourishing stomach, tonifying spleen, lubricating intestines and helping digestion, and achieves the aims of consolidating basis and cultivating origin, and treating both principal and secondary aspects of diseases;
thirdly, the traditional Chinese medicine composition has important significance for reducing the use of antibiotics in the chicken feeding process, improving the health condition of chicken and improving the food safety of chicken and products thereof, and has considerable economic benefit and social prospect;
fourthly, according to the preparation method of the invention, according to the characteristics of each component in the prescription, the components are extracted step by step after being subjected to superfine grinding, so that the effective components in each component are fully dissolved out, and the curative effect of the traditional Chinese medicine composition is improved;
fifthly, in the preparation method, the cyclodextrin is added to slowly release the active ingredients in the traditional Chinese medicine composition, so that the half-life period of the traditional Chinese medicine composition is improved, the blood concentration is stable, the peak-valley phenomenon is avoided, the toxic and side effects of the medicine are reduced, the total dosage of the medicine is reduced, the maximum medicine effect is achieved by using the minimum dosage, the frequent medicine feeding is avoided, and the labor intensity of a feeder is reduced.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention.
Detailed Description
The present invention is further described in detail below with reference to examples so that those skilled in the art can practice the invention with reference to the description.
It is to be noted that the experimental procedures described in the following examples are conventional ones unless otherwise specified, and the reagents and materials described therein are commercially available without otherwise specified.
Example 1:
the traditional Chinese medicine composition for treating necrotic enteritis of chickens is characterized by being mainly prepared from the following raw materials in parts by weight: 15 parts of phellodendron, 25 parts of fructus aurantii, 25 parts of cortex magnoliae officinalis, 25 parts of combined spicebush root, 25 parts of pericarpium arecae, 40 parts of bighead atractylodes rhizome, 25 parts of poria cocos, 25 parts of Chinese yam, 25 parts of hawthorn, 15 parts of radix sophorae flavescentis, 25 parts of medicated leaven, 15 parts of divaricate saposhnikovia root, 25 parts of herba patriniae, 25 parts of Chinese pulsatilla root, 25 parts of tree peony bark, 25 parts of selfheal spike, 8 parts of liquorice, 25 parts of biliary tree, 25 parts of purple perilla, 25 parts of cassia occidentalis, 35 parts of astragalus membranaceus, 30 parts of pomegranate rind, 40 parts of monkshood, 40 parts of dandelion, 40.
A preparation method of a traditional Chinese medicine composition for treating necrotic enteritis of chickens comprises the following steps:
step one, respectively cleaning and selecting each component in the formula, and then carrying out superfine grinding to 500 meshes;
weighing the phellodendron, the sophora flavescens, the patrinia, the Chinese pulsatilla root, the tree peony bark, the selfheal, the nauclea officinalis, the dandelion, the bunge corydalis herb and the scutellaria baicalensis in parts by weight, and fully and uniformly mixing to obtain first mixed powder; weighing the lindera aggregate, the divaricate saposhnikovia root, the liquorice, the purple perilla, the pomegranate bark, the monkshood and the Chinese tallow tree in parts by weight, and fully and uniformly mixing to obtain second mixed powder; weighing the bitter orange, the magnolia obavata, the areca peel, the bighead atractylodes rhizome, the hawthorn, the poria cocos, the Chinese yam, the astragalus mongholicus, the medicated leaven and the cassia occidentalis in parts by weight, and fully mixing to obtain third mixed powder;
step three, carrying out reflux extraction on the first mixed powder for 3 times by using ethanol with the volume fraction of 70% to obtain a first extracting solution, carrying out reduced pressure concentration on the first extracting solution until the volume fraction of the ethanol is 30% to obtain a distillate and a concentrated solution, and carrying out continuous reflux extraction on the concentrated solution for 3 times to obtain a second extracting solution;
step four, carrying out reflux extraction on the second mixed powder for 3 times by using the distillate to obtain a third extracting solution;
step five, carrying out reflux extraction on the third mixed powder for 3 times by using water to obtain a fourth extracting solution;
and step six, combining the second extracting solution, the third extracting solution and the fourth extracting solution, decocting at 95 ℃ for 5 hours, and concentrating under reduced pressure until the relative density is 1.25 to obtain the traditional Chinese medicine composition for treating the necrotic enteritis.
The preparation method of the traditional Chinese medicine composition for treating chicken necrotic enteritis comprises the third step of mixing 70% by volume of ethanol and the first mixed powder in a mass ratio of 15: 1.
In the fifth step, the mass ratio of the water to the third mixed powder is 10:1, the reflux extraction temperature is 50 ℃, and the reflux extraction time is 2 hours each time.
The preparation method of the traditional Chinese medicine composition for treating chicken necrotic enteritis comprises the third step and the fourth step, wherein the temperature of reflux extraction is 70 ℃, and the time of each reflux extraction is 1 hour.
Example 2:
the traditional Chinese medicine composition for treating necrotic enteritis of chickens is characterized by being mainly prepared from the following raw materials in parts by weight: 20 parts of phellodendron, 30 parts of fructus aurantii, 30 parts of cortex magnoliae officinalis, 30 parts of combined spicebush root, 30 parts of pericarpium arecae, 50 parts of bighead atractylodes rhizome, 30 parts of poria cocos, 30 parts of Chinese yam, 30 parts of hawthorn, 20 parts of radix sophorae flavescentis, 30 parts of medicated leaven, 20 parts of divaricate saposhnikovia root, 30 parts of herba patriniae, 30 parts of Chinese pulsatilla root, 30 parts of tree peony bark, 30 parts of selfheal, 10 parts of liquorice, 30 parts of biliary tree, 30 parts of purple perilla, 30 parts of cassia occidentalis, 43 parts of astragalus mongholicus, 35 parts of pomegranate rind, 50 parts of monkshood, 50 parts of dandelion, 50 parts.
A preparation method of a traditional Chinese medicine composition for treating necrotic enteritis of chickens comprises the following steps:
step one, cleaning and selecting each component in the formula respectively, and then carrying out superfine grinding to 550 meshes;
weighing the phellodendron, the sophora flavescens, the patrinia, the Chinese pulsatilla root, the tree peony bark, the selfheal, the nauclea officinalis, the dandelion, the bunge corydalis herb and the scutellaria baicalensis in parts by weight, and fully and uniformly mixing to obtain first mixed powder; weighing the lindera aggregate, the divaricate saposhnikovia root, the liquorice, the purple perilla, the pomegranate bark, the monkshood and the Chinese tallow tree in parts by weight, and fully and uniformly mixing to obtain second mixed powder; weighing the bitter orange, the magnolia obavata, the areca peel, the bighead atractylodes rhizome, the hawthorn, the poria cocos, the Chinese yam, the astragalus mongholicus, the medicated leaven and the cassia occidentalis in parts by weight, and fully mixing to obtain third mixed powder;
step three, carrying out reflux extraction on the first mixed powder for 2 times by using 75% ethanol in volume fraction to obtain a first extracting solution, carrying out reduced pressure concentration on the first extracting solution until the volume fraction of the ethanol is 35% to obtain a distillate and a concentrated solution, and carrying out continuous reflux extraction on the concentrated solution for 2 times to obtain a second extracting solution;
step four, carrying out reflux extraction on the second mixed powder for 2 times by using the distillate to obtain a third extracting solution;
step five, carrying out reflux extraction on the third mixed powder for 2 times to obtain a fourth extracting solution;
and step six, combining the second extracting solution, the third extracting solution and the fourth extracting solution, decocting at 96 ℃ for 4 hours, and concentrating under reduced pressure until the relative density is 1.28 to obtain the traditional Chinese medicine composition for treating the necrotic enteritis.
The preparation method of the traditional Chinese medicine composition for treating chicken necrotic enteritis comprises the third step of mixing 75% by volume of ethanol and the first mixed powder in a mass ratio of 18: 1.
In the fifth step, the mass ratio of the water to the third mixed powder is 12:1, the reflux extraction temperature is 55 ℃, and the reflux extraction time is 1.5h each time.
The preparation method of the traditional Chinese medicine composition for treating chicken necrotic enteritis comprises the third step and the fourth step, wherein the reflux extraction temperature is 75 ℃, and the reflux extraction time is 0.8h each time.
The preparation method of the traditional Chinese medicine composition for treating chicken necrotic enteritis is characterized in that in the sixth step, 30 parts by weight of cyclodextrin is added before the reduced pressure concentration, and the mixture is uniformly mixed.
Example 3:
the traditional Chinese medicine composition for treating necrotic enteritis of chickens is characterized by being mainly prepared from the following raw materials in parts by weight: 20 parts of phellodendron, 30 parts of fructus aurantii, 30 parts of cortex magnoliae officinalis, 30 parts of combined spicebush root, 30 parts of pericarpium arecae, 50 parts of bighead atractylodes rhizome, 30 parts of poria cocos, 30 parts of Chinese yam, 30 parts of hawthorn, 20 parts of radix sophorae flavescentis, 30 parts of medicated leaven, 20 parts of divaricate saposhnikovia root, 30 parts of herba patriniae, 30 parts of Chinese pulsatilla root, 30 parts of tree peony bark, 30 parts of selfheal, 10 parts of liquorice, 30 parts of biliary tree, 30 parts of purple perilla, 30 parts of cassia occidentalis, 43 parts of astragalus mongholicus, 35 parts of pomegranate rind, 50 parts of monkshood, 50 parts of dandelion, 50 parts.
A preparation method of a traditional Chinese medicine composition for treating necrotic enteritis of chickens comprises the following steps:
step one, respectively cleaning and selecting each component in the formula, and then carrying out superfine grinding to 600 meshes;
weighing the phellodendron, the sophora flavescens, the patrinia, the Chinese pulsatilla root, the tree peony bark, the selfheal, the nauclea officinalis, the dandelion, the bunge corydalis herb and the scutellaria baicalensis in parts by weight, and fully and uniformly mixing to obtain first mixed powder; weighing the lindera aggregate, the divaricate saposhnikovia root, the liquorice, the purple perilla, the pomegranate bark, the monkshood and the Chinese tallow tree in parts by weight, and fully and uniformly mixing to obtain second mixed powder; weighing the bitter orange, the magnolia obavata, the areca peel, the bighead atractylodes rhizome, the hawthorn, the poria cocos, the Chinese yam, the astragalus mongholicus, the medicated leaven and the cassia occidentalis in parts by weight, and fully mixing to obtain third mixed powder;
step three, carrying out reflux extraction on the first mixed powder for 2 times by using 80 volume percent ethanol to obtain a first extracting solution, carrying out reduced pressure concentration on the first extracting solution until the volume percent of the ethanol is 40 percent to obtain a distillate and a concentrated solution, and then carrying out reflux extraction on the concentrated solution for 2 times to obtain a second extracting solution;
step four, carrying out reflux extraction on the second mixed powder for 2 times by using the distillate to obtain a third extracting solution;
step five, carrying out reflux extraction on the third mixed powder for 2 times to obtain a fourth extracting solution;
and step six, combining the second extracting solution, the third extracting solution and the fourth extracting solution, decocting at 98 ℃ for 3 hours, and concentrating under reduced pressure until the relative density is 1.30 to obtain the traditional Chinese medicine composition for treating the necrotic enteritis.
The preparation method of the traditional Chinese medicine composition for treating chicken necrotic enteritis comprises the third step of mixing 80% by volume of ethanol and the first mixed powder in a mass ratio of 20: 1.
In the fifth step, the mass ratio of the water to the third mixed powder is 15:1, the reflux extraction temperature is 60 ℃, and the reflux extraction time is 1 hour each time.
The preparation method of the traditional Chinese medicine composition for treating chicken necrotic enteritis comprises the third step and the fourth step, wherein the temperature of reflux extraction is 80 ℃, and the time of each reflux extraction is 0.5 h.
The preparation method of the traditional Chinese medicine composition for treating chicken necrotic enteritis is characterized in that in the sixth step, 40 parts by weight of cyclodextrin is added before the reduced pressure concentration, and the mixture is uniformly mixed.
Example 4:
the traditional Chinese medicine composition for treating necrotic enteritis of chickens is characterized by being mainly prepared from the following raw materials in parts by weight: 25 parts of phellodendron, 35 parts of fructus aurantii, 35 parts of cortex magnoliae officinalis, 35 parts of combined spicebush root, 35 parts of pericarpium arecae, 60 parts of bighead atractylodes rhizome, 35 parts of poria cocos, 35 parts of Chinese yam, 35 parts of hawthorn, 25 parts of radix sophorae flavescentis, 35 parts of medicated leaven, 25 parts of divaricate saposhnikovia root, 35 parts of herba patriniae, 35 parts of Chinese pulsatilla root, 35 parts of tree peony bark, 35 parts of selfheal, 12 parts of liquorice, 35 parts of lignum naucleae, 35 parts of purple perilla, 35 parts of cassia occidentalis, 50 parts of astragalus membranaceus, 40 parts of pomegranate rind, 60 parts of monkshood, 60 parts of dandelion.
A preparation method of a traditional Chinese medicine composition for treating necrotic enteritis of chickens comprises the following steps:
step one, respectively cleaning and selecting each component in the formula, and then carrying out superfine grinding to 600 meshes;
weighing the phellodendron, the sophora flavescens, the patrinia, the Chinese pulsatilla root, the tree peony bark, the selfheal, the nauclea officinalis, the dandelion, the bunge corydalis herb and the scutellaria baicalensis in parts by weight, and fully and uniformly mixing to obtain first mixed powder; weighing the lindera aggregate, the divaricate saposhnikovia root, the liquorice, the purple perilla, the pomegranate bark, the monkshood and the Chinese tallow tree in parts by weight, and fully and uniformly mixing to obtain second mixed powder; weighing the bitter orange, the magnolia obavata, the areca peel, the bighead atractylodes rhizome, the hawthorn, the poria cocos, the Chinese yam, the astragalus mongholicus, the medicated leaven and the cassia occidentalis in parts by weight, and fully mixing to obtain third mixed powder;
step three, carrying out reflux extraction on the first mixed powder for 3 times by using 75% ethanol in volume fraction to obtain a first extracting solution, carrying out reduced pressure concentration on the first extracting solution until the volume fraction of the ethanol is 35% to obtain a distillate and a concentrated solution, and carrying out continuous reflux extraction on the concentrated solution for 3 times to obtain a second extracting solution;
step four, carrying out reflux extraction on the second mixed powder for 3 times by using the distillate to obtain a third extracting solution;
step five, carrying out reflux extraction on the third mixed powder for 3 times by using water to obtain a fourth extracting solution;
and step six, combining the second extracting solution, the third extracting solution and the fourth extracting solution, decocting at 98 ℃ for 5 hours, and concentrating under reduced pressure until the relative density is 1.30 to obtain the traditional Chinese medicine composition for treating the necrotic enteritis.
The preparation method of the traditional Chinese medicine composition for treating chicken necrotic enteritis comprises the third step of mixing 75% by volume of ethanol and the first mixed powder in a mass ratio of 20: 1.
In the fifth step, the mass ratio of the water to the third mixed powder is 15:1, the reflux extraction temperature is 60 ℃, and the reflux extraction time is 2 hours each time.
The preparation method of the traditional Chinese medicine composition for treating chicken necrotic enteritis comprises the third step and the fourth step, wherein the reflux extraction temperature is 80 ℃, and the reflux extraction time is 1 hour each time.
The preparation method of the traditional Chinese medicine composition for treating chicken necrotic enteritis is characterized in that in the sixth step, 50 parts by weight of cyclodextrin is added before the reduced pressure concentration, and the mixture is uniformly mixed.
Comparative example 1:
in order to further verify the clinical efficacy of the traditional Chinese medicine composition on necrotic enteritis in chickens, broiler chickens of the same age of the same day with the onset of natural infection are selected and randomly divided into 5 groups, each group has 1000 feathers, water is used as a blank control group, penicillin, oxytetracycline and ciprofloxacin are used as positive control groups, and the traditional Chinese medicine composition prepared in the embodiment 3 is used as an experimental group for carrying out a comparative test. Wherein, the penicillin, the terramycin and the ciprofloxacin are administrated according to the instruction, 5 days are taken as a treatment course, the experimental group is fed with 20kg of the mixed material of every 10g of the traditional Chinese medicine composition for 1 time every day, 5 days are taken as a treatment course, the rest feeding conditions of the control group and the experimental group are consistent, and the experimental results are shown in table 1.
TABLE 1 comparative experimental results (statistical data after 5 days)
| Group of | Sample number (Yu) | Death number (Yu) | Mortality (%) |
| Blank control group | 1000 | 269 | 26.9 |
| Penicillin control group | 1000 | 77 | 7.7 |
| Oxytetracycline control group | 1000 | 81 | 8.1 |
| Ciprofloxacin control group | 1000 | 68 | 6.8 |
| The Chinese medicinal composition of the invention | 1000 | 13 | 1.3 |
As can be seen from table 1, the mortality of the traditional Chinese medicine composition of the present invention is significantly reduced compared to the control group of penicillin and the control group of oxytetracycline combined with ciprofloxacin, which indicates that the clinical efficacy of the traditional Chinese medicine composition of the present invention is significant.
In the experimental process, the penicillin control group and the oxytetracycline control group are still dead sick chickens when the medicines are taken on the 5 th day, the ciprofloxacin control group is still dead sick chickens when the medicines are taken on the 4 th day, and the sick chickens are not dead when the traditional Chinese medicine composition is taken on the 3 rd day.
While embodiments of the invention have been disclosed above, it is not limited to the applications listed in the description and the embodiments, which are fully applicable in all kinds of fields of application of the invention, and further modifications may readily be effected by those skilled in the art, so that the invention is not limited to the specific details without departing from the general concept defined by the claims and the scope of equivalents.
Claims (6)
1. The traditional Chinese medicine composition for treating necrotic enteritis of chickens is characterized by being prepared from the following raw materials in parts by weight: 15-25 parts of phellodendron, 25-35 parts of fructus aurantii, 25-35 parts of cortex magnoliae officinalis, 25-35 parts of radix linderae, 25-35 parts of pericarpium arecae, 40-60 parts of bighead atractylodes rhizome, 25-35 parts of poria cocos, 25-35 parts of Chinese yam, 25-35 parts of hawthorn, 15-25 parts of radix sophorae flavescentis, 25-35 parts of medicated leaven, 15-25 parts of divaricate saposhnikovia root, 25-35 parts of dahurian patrinia herb, 25-35 parts of Chinese pulsatilla root, 25-35 parts of tree peony bark, 25-35 parts of selfheal, 8-12 parts of liquorice, 25-35 parts of lignum naucleae officinalis, 25-35 parts of purple perilla, 25-35 parts of cassia occidentalis, 35-50 parts of astragalus root, 30-40 parts of pomegranate rind, 40-60 parts of monkshood, 40-60 parts of dandelion, 40-60 parts of bunge;
the preparation method comprises the following steps:
step one, after each component in the formula is respectively cleaned and selected, the components are subjected to superfine grinding to 500-mesh and 600-mesh;
weighing the phellodendron, the sophora flavescens, the patrinia, the Chinese pulsatilla root, the tree peony bark, the selfheal, the nauclea officinalis, the dandelion, the bunge corydalis herb and the scutellaria baicalensis in parts by weight, and fully and uniformly mixing to obtain first mixed powder; weighing the lindera aggregate, the divaricate saposhnikovia root, the liquorice, the purple perilla, the pomegranate bark, the monkshood and the Chinese tallow tree in parts by weight, and fully and uniformly mixing to obtain second mixed powder; weighing the bitter orange, the magnolia obavata, the areca peel, the bighead atractylodes rhizome, the hawthorn, the poria cocos, the Chinese yam, the astragalus mongholicus, the medicated leaven and the cassia occidentalis in parts by weight, and fully mixing to obtain third mixed powder;
step three, carrying out reflux extraction on the first mixed powder for 2-3 times by using ethanol with the volume fraction of 70-80% to obtain a first extracting solution, carrying out reduced pressure concentration on the first extracting solution until the volume fraction of the ethanol is 30-40% to obtain a distillate and a concentrated solution, and carrying out reflux extraction on the concentrated solution for 2-3 times to obtain a second extracting solution;
step four, carrying out reflux extraction on the second mixed powder for 2-3 times by using the distillate to obtain a third extracting solution;
step five, carrying out reflux extraction on the third mixed powder for 2-3 times by using water to obtain a fourth extracting solution;
and step six, combining the second extracting solution, the third extracting solution and the fourth extracting solution, decocting at 95-98 ℃ for 3-5h, and concentrating under reduced pressure until the relative density is 1.25-1.30 to obtain the traditional Chinese medicine composition for treating the necrotic enteritis of the chickens.
2. The traditional Chinese medicine composition for treating necrotic enteritis in chickens according to claim 1, is prepared from the following raw materials in parts by weight: 20 parts of phellodendron, 30 parts of fructus aurantii, 30 parts of cortex magnoliae officinalis, 30 parts of combined spicebush root, 30 parts of pericarpium arecae, 50 parts of bighead atractylodes rhizome, 30 parts of poria cocos, 30 parts of Chinese yam, 30 parts of hawthorn, 20 parts of radix sophorae flavescentis, 30 parts of medicated leaven, 20 parts of divaricate saposhnikovia root, 30 parts of herba patriniae, 30 parts of Chinese pulsatilla root, 30 parts of tree peony bark, 30 parts of selfheal, 10 parts of liquorice, 30 parts of biliary tree, 30 parts of purple perilla, 30 parts of cassia occidentalis, 43 parts of astragalus mongholicus, 35 parts of pomegranate rind, 50 parts of monkshood, 50 parts of dandelion, 50 parts.
3. The traditional Chinese medicine composition for treating necrotic enteritis in chickens according to claim 1, wherein in the third step, the mass ratio of ethanol with a volume fraction of 70-80% to the first mixed powder is 15-20: 1.
4. The traditional Chinese medicine composition for treating necrotic enteritis in chickens according to claim 1, wherein in the fifth step, the mass ratio of water to the third mixed powder is 10-15:1, the reflux extraction temperature is 50-60 ℃, and the time of each reflux extraction is 1-2 h.
5. The traditional Chinese medicine composition for treating necrotic enteritis in chickens according to claim 1, wherein in the third step and the fourth step, the temperature of reflux extraction is 70-80 ℃, and the time of each reflux extraction is 0.5-1 h.
6. The traditional Chinese medicine composition for treating necrotic enteritis in chicken as claimed in claim 1, wherein in the sixth step, 30-50 parts by weight of cyclodextrin is added before the concentration under reduced pressure, and the mixture is mixed uniformly.
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| CN106177314A (en) * | 2016-08-24 | 2016-12-07 | 冉俊平 | A kind of traumatic injury synthetism medicated wine and preparation method thereof |
| CN106344802A (en) * | 2016-09-30 | 2017-01-25 | 安徽华澳生物技术有限公司 | Drug for preventing and treating necrotic enteritis of broiler chicken of two to six weeks |
| CN106620430A (en) * | 2016-12-09 | 2017-05-10 | 河池市技术开发中心 | Traditional Chinese medicine composition used for treating piglet diarrhea and preparation method thereof |
| CN107375575A (en) * | 2017-08-04 | 2017-11-24 | 安徽省泾县丰瑞水产科技有限公司 | A kind of Chinese herbal medicine for treating sturgeon fin rot and preparation method thereof |
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| CN1939378A (en) * | 2006-09-25 | 2007-04-04 | 南京中山制药有限公司 | Preparation of blood-activating and pain-stopping capsules |
| CN101653446A (en) * | 2009-09-16 | 2010-02-24 | 天津市慧瑞动物药业有限公司 | Composition for treating chicken necrotizing enterocolitis and preparation method thereof |
| CN103520495A (en) * | 2013-09-27 | 2014-01-22 | 青岛绿曼生物工程有限公司 | Pure traditional Chinese medicine composition for treatment of necrotic enteritis of poultry and preparation method thereof |
| CN104758799A (en) * | 2015-03-06 | 2015-07-08 | 钟云仙 | Chinese medicinal composition for treatment of poussin necrotic enteritis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1939378A (en) * | 2006-09-25 | 2007-04-04 | 南京中山制药有限公司 | Preparation of blood-activating and pain-stopping capsules |
| CN101653446A (en) * | 2009-09-16 | 2010-02-24 | 天津市慧瑞动物药业有限公司 | Composition for treating chicken necrotizing enterocolitis and preparation method thereof |
| CN103520495A (en) * | 2013-09-27 | 2014-01-22 | 青岛绿曼生物工程有限公司 | Pure traditional Chinese medicine composition for treatment of necrotic enteritis of poultry and preparation method thereof |
| CN104758799A (en) * | 2015-03-06 | 2015-07-08 | 钟云仙 | Chinese medicinal composition for treatment of poussin necrotic enteritis |
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