CN102488854B - Composite propolis composition for treating cat/dog dyspepsia and preparation method thereof - Google Patents

Abstract

The invention discloses a composite propolis composition for treating cat/dog dyspepsia and a preparation method thereof, and relates to the field of animal medicine. The preparation method of the composite propolis composition for treating cat/dog dyspepsia comprises the following steps of 1, respectively crushing raw materials of propolis, immature bitter orange, Chinese magnoliavine, anemone root, pilose asiabell root, coptis, mixture of scorch-fried malt, scorch-fried haw and scorch-fried massa medicata fermentata, and milkvetch root into superfine powder, and sieving the superfine powder by a sieve of 700 meshes, 2, weighing 15 to 35 parts by weight of the propolis superfine powder, 10 to 45 parts by weight of the immature bitter orange superfine powder, 10 to 35 parts by weight of the Chinese magnoliavine superfine powder and 15 to 40 parts by weight of the anemone root superfine powder, mixing for 5 to 10 minutes until the mixture is uniform, 3, weighing 15 to 35 parts by weight of the pilose asiabell root superfine powder, 15 to 35 parts by weight of the coptis superfine powder, 10 to 35 parts by weight of the mixture of scorch-fried malt, scorch-fried haw and scorch-fried massa medicata fermentata, and 10 to 35 parts by weight of the milkvetch root, mixing for 5 to 10 minutes until the mixture is uniform, and 4, mixing the mixture obtained by the step 2 and the mixture obtained by the step 3, and stirring for 10 to 15 minutes until the mixture is uniform. The preparation method provided by the invention adopts a reasonable formula and has simple processes. The composite propolis composition for treating cat/dog dyspepsia does not have toxic and side effects, does not produce pollution and drug residues, avoids drug resistance, and has a superfine particle size, high bioavailability and obvious curative effect, wherein a clinical test proves that the composite propolis composition provided by the invention has a special effect of treating cat/dog dyspepsia.

Description

A kind of dyspeptic compound bee-glue composition of dog cat and preparation method thereof for the treatment of

Technical field

The present invention relates to animal field of medicaments, particularly a kind of dyspeptic compound bee-glue composition for the treatment of dog cat and preparation method thereof that is specifically designed to.

Background technology

Dog cat dyspepsia refers to food stagnation gastrointestinal, transformation failure of spleen, and due to abnormal ascending-descending of QI, excrement acid is smelly in order to let out for clinical main manifestations, the slow-witted abdominal distention of food, thick fur are turbid, the sliding number of pulse condition, sometimes vomits, lets out rear disease slow.Primary disease sickness rate and case fatality rate are higher, all can occur throughout the year, are one of principal diseases of harm dog cat house pet industry.

Western medical treatment mainly be take sterilization, antiinflammatory etc. as main, and clinical effectiveness is not very desirable.And the traditional Chinese medical science thinks that this disease belongs to abnormal ascending-descending of QI, food stagnation gastrointestinal, due to transformation failure of spleen, it is the principle of leading that treatment should adopt dyspepsia and intestinal stasis relieving.

This disease almost spreads all over the world all livestock culturings country, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And antimicrobial drug is because its toxic and side effects by force, easily produces the problems such as drug resistance and drug residue in Western medicine, clinical practice is very limited.

Therefore research and develop and a kind ofly treat that dog cat dyspepticly has no side effect, drug residue free, the specific medicament producing that has no drug resistance be one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no side effect, have no drug resistance and the dyspeptic compound bee-glue composition of effective treatment dog cat of drug residue and preparation method thereof.

Implementation of the present invention is as follows for achieving the above object: a kind of dyspeptic compound bee-glue composition of dog cat for the treatment of, by following component by weight mixed preparing form: propolis 15-35 part, Fructus Aurantii Immaturus 15-45 part, Fructus Schisandrae Chinensis 10-35 part, Radix Pulsatillae 15-40 part, Radix Codonopsis 15-35 part, Rhizoma Coptidis 10-35 part, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10-35 part, Radix Astragali 10-35 part.

On the basis of such scheme, described various component optimum ratio amounts are: 25 parts of propolis, 30 parts of Fructus Aurantii Immaturuss, 25 parts of Fructus Schisandrae Chinensis, 30 parts of the Radix Pulsatillaes, 25 parts of Radix Codonopsis, 25 parts of Rhizoma Coptidis, 25 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 25 parts of the Radixs Astragali.

Treat a preparation method for the dyspeptic compound bee-glue composition of dog cat, carry out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight propolis 15-35 part, Fructus Aurantii Immaturus 15-45 part, Fructus Schisandrae Chinensis 10-35 part, Radix Pulsatillae 15-40 part, mix 5-10 minute to even;

(3) take by weight Radix Codonopsis 15-35 part, Rhizoma Coptidis 10-35 part, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10-35 part, Radix Astragali 10-35 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Propolis: bitter, acrid, cold, return spleen, lung, stomach warp, there is anti-bacteria and anti-virus, antalgesic-antipruritic, promotion tissue regeneration, improve immunity, antiallergic is oxidized, stop blooding, moisturize, the function of relieving cough and asthma, protection gastrointestinal mucosa.

Rhizoma Coptidis: bitter, cold, return liver, the heart, spleen, stomach, gallbladder, large intestine channel, there is the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly damp-heat dysentery, hyperactivity of heart-fire, excessiveness of stomach-fire, dampness-heat in the liver and gallbladder, conjunctival congestion and swelling pain, fire-toxin carbuncle sore etc.

The Radix Pulsatillae: bitter, cold, return stomach, large intestine channel, there is the function of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery; Cure mainly toxic-heat and blood stasis, damp and hot removing heat from blood etc.

The Radix Astragali: sweet, tepor, return spleen, lung meridian, there is the function of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Curing mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficultly bursts, bursts for a long time and do not hold back etc.

Fructus Aurantii Immaturus: bitter, cold, return lung, the heart, tri-jiao channel, there is the function of eliminating fire and detoxication, clearing away heat and promoting diuresis, removing heat from blood; Cure mainly three warmers intenseness of heat, jaundice due to damp-heat, pyretic stranguria, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, heat in blood epistaxis etc.

Fructus Schisandrae Chinensis: sweet, sour, warm, return lung, kidney, heart channel, there is the astringing intestine to stop diarrhea of astringing the lung, the function of the hidroschesis that promotes the production of body fluid, reinforcing the kindey to control nocturnal emission; Cure mainly that the deficiency of the lung is breathed with cough, chronic diarrhea etc.

Radix Codonopsis: sweet, flat, return spleen, lung meridian, there is the function of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting; Cure mainly weakness of the spleen and stomach, eat diarrhoea, cough and asthma due to lung deficiency, fatigue and lack of strength, the deficiency of vital energy less and hang down de-etc.

JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata): sweet, flat, warm, GUIXIN, liver, kidney, large intestine channel, have invigorating the spleen and regulating the stomach, the stagnant function of soothing the liverization; Curing mainly food stagnation does not disappear, vomits and have loose bowels etc.

All taste Chinese medicine, according to Chinese medical theory compatible combination, for the dyspeptic paathogenic factor of dog cat and clinical symptoms, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, have no side effect, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention, according to Chinese veterinarian's traditional theory, optimizes this eight tastes Chinese medicine, and makes them according to optimum ratio, form pure Chinese powder medicine, and clinical practice proves that treatment dog cat dyspepsia is had to specially good effect.

The specific embodiment

Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:

Embodiment 1

A kind of dyspeptic compound bee-glue composition of dog cat and preparation method thereof for the treatment of: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 150 parts of propolis, 150 parts of Fructus Aurantii Immaturuss, 100 parts of Fructus Schisandrae Chinensis, 150 parts of the Radix Pulsatillaes, mix 5-10 minute to even;

(3) take by weight 150 parts of Radix Codonopsis, 100 parts of Rhizoma Coptidis, 100 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 100 parts of the Radixs Astragali, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of dyspeptic compound bee-glue composition of dog cat and preparation method thereof for the treatment of: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 250 parts of propolis, 300 parts of Fructus Aurantii Immaturuss, 250 parts of Fructus Schisandrae Chinensis, 250 parts of the Radix Pulsatillaes, mix 5-10 minute to even;

(3) take by weight 250 parts of Radix Codonopsis, 250 parts of Rhizoma Coptidis, 250 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 250 parts of the Radixs Astragali, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of dyspeptic compound bee-glue composition of dog cat and preparation method thereof for the treatment of: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 350 parts of propolis, 450 parts of Fructus Aurantii Immaturuss, 350 parts of Fructus Schisandrae Chinensis, 400 parts of the Radix Pulsatillaes, mix 5-10 minute to even;

(3) take by weight 350 parts of Radix Codonopsis, 350 parts of Rhizoma Coptidis, 350 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 350 parts of the Radixs Astragali, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

By the ill dog cat of product feeding of the present invention etc., a day dose is: by per kilogram of body weight of the present invention, gavage or lick and lick 5 grams-10 grams, every day 1-2 time, be used in conjunction 3-5 day; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.

Table is the present invention and the applicable cases contrast of the other medicines treatment dyspeptic field of dog cat:

Numbering	Group	Case fatality rate %	Cure rate %	During end, there is symptom rate %
					I	Blank group	11.3	73.1	15.6
II	The Fructus Aurantii Immaturus intestinal stasis relieving group of faling apart	7.4	83.7	8.9
					III	Present composition group	3.3	92.5	4.2

This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P < 0.01) with the loose group of Fructus Aurantii Immaturus intestinal stasis relieving aspect cure rate.

Above-mentioned detailed description of dyspeptic compound bee-glue composition of this treatment dog cat and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. a treatment dog cat dyspeptic compound bee-glue composition, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Fructus Aurantii Immaturus 15-45 part, Fructus Schisandrae Chinensis 10-35 part, Radix Pulsatillae 15-40 part, 15-35 parts of Radix Codonopsis, Rhizoma Coptidis 10-35 part, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10-35 part, Radix Astragali 10-35 part.

2. the dyspeptic compound bee-glue composition for the treatment of dog cat according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 30 parts of Fructus Aurantii Immaturuss, 25 parts of Fructus Schisandrae Chinensis, 30 parts of the Radix Pulsatillaes, 25 parts of Radix Codonopsis, 25 parts of Rhizoma Coptidis, 25 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), 25 parts of the Radixs Astragali.

3. a preparation method for the dyspeptic compound bee-glue composition for the treatment of according to claim 1 dog cat, is characterized in that carrying out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 15-40 parts of propolis 15-35 parts, Fructus Aurantii Immaturus 15-45 part, Fructus Schisandrae Chinensis 10-35 part, the Radix Pulsatillae, mix 5-10 minute to evenly;

(3) take by weight 10-35 parts of Radix Codonopsis 15-35 parts, Rhizoma Coptidis 10-35 part, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10-35 part, the Radix Astragali, mix 5-10 minute to evenly;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.