CN102488854A - Composite propolis composition for treating cat/dog dyspepsia and preparation method thereof - Google Patents

Abstract

The invention discloses a composite propolis composition for treating cat/dog dyspepsia and a preparation method thereof, and relates to the field of animal medicine. The preparation method of the composite propolis composition for treating cat/dog dyspepsia comprises the following steps of 1, respectively crushing raw materials of propolis, immature bitter orange, Chinese magnoliavine, anemone root, pilose asiabell root, coptis, mixture of scorch-fried malt, scorch-fried haw and scorch-fried massa medicata fermentata, and milkvetch root into superfine powder, and sieving the superfine powder by a sieve of 700 meshes, 2, weighing 15 to 35 parts by weight of the propolis superfine powder, 10 to 45 parts by weight of the immature bitter orange superfine powder, 10 to 35 parts by weight of the Chinese magnoliavine superfine powder and 15 to 40 parts by weight of the anemone root superfine powder, mixing for 5 to 10 minutes until the mixture is uniform, 3, weighing 15 to 35 parts by weight of the pilose asiabell root superfine powder, 15 to 35 parts by weight of the coptis superfine powder, 10 to 35 parts by weight of the mixture of scorch-fried malt, scorch-fried haw and scorch-fried massa medicata fermentata, and 10 to 35 parts by weight of the milkvetch root, mixing for 5 to 10 minutes until the mixture is uniform, and 4, mixing the mixture obtained by the step 2 and the mixture obtained by the step 3, and stirring for 10 to 15 minutes until the mixture is uniform. The preparation method provided by the invention adopts a reasonable formula and has simple processes. The composite propolis composition for treating cat/dog dyspepsia does not have toxic and side effects, does not produce pollution and drug residues, avoids drug resistance, and has a superfine particle size, high bioavailability and obvious curative effect, wherein a clinical test proves that the composite propolis composition provided by the invention has a special effect of treating cat/dog dyspepsia.

Description

Dyspeptic compound bee-glue composition of a kind of treatment dog cat and preparation method thereof

Technical field

The present invention relates to the animal field of medicaments, particularly a kind of dyspeptic compound bee-glue composition of treatment dog cat and preparation method thereof that is specifically designed to.

Background technology

Dog cat dyspepsia is meant the food stagnation gastrointestinal, due to the transformation failure of spleen, abnormal ascending-descending of QI, clinical mainly show as let out that excrement acid is smelly, the slow-witted abdominal distention of food, turbid, the sliding number of pulse condition of thick fur, it is sick slow to vomit, let out the back sometimes.Primary disease sickness rate and case fatality rate are higher, all can take place throughout the year, are one of principal diseases of harm dog cat house pet industry.

Western medical treatment is main with antibacterial, antiinflammatory etc. mainly, and clinical effectiveness is not very desirable.And the traditional Chinese medical science thinks that this disease belongs to abnormal ascending-descending of QI, food stagnation gastrointestinal, and due to the transformation failure of spleen, it is the principle of leading that treatment should adopted dyspepsia and intestinal stasis relieving.

This disease almost spreads all over all livestock culturing countries of the world, distributes very extensively.At present, treat this disease the most frequently used be Chinese medicine and Western medicine, Chinese medicine is because its prescription is unreasonable or just simple the pulverizing, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And antimicrobial drug produces problems such as drug resistance and drug residue owing to its toxic and side effects is strong, easy in the Western medicine, and clinical practice is very limited.

Therefore research and develop and a kind ofly treat that the dog cat dyspepticly has no side effect, drug residue free, the specific medicament that produces that has no drug resistance be one of this field scientific research technical staff new problem anxious to be solved.

Summary of the invention

The objective of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, effect obviously, have no side effect, have no drug resistance and the dyspeptic compound bee-glue composition of effective treatment dog cat of drug residue and preparation method thereof.

Following for realizing the embodiment that above-mentioned purpose the present invention adopted: the dyspeptic compound bee-glue composition of a kind of treatment dog cat, by following component by weight mixed preparing form: propolis 15-35 part, Fructus Aurantii Immaturus 15-45 part, Fructus Schisandrae Chinensis 10-35 part, Radix Pulsatillae 15-40 part, Radix Codonopsis 15-35 part, Rhizoma Coptidis 10-35 part, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10-35 part, Radix Astragali 10-35 part.

On the basis of such scheme, said various component optimum ratio amounts are: 25 parts of propolis, 30 parts of Fructus Aurantii Immaturuss, 25 parts of Fructus Schisandrae Chinensis, 30 parts of the Radix Pulsatillaes, 25 parts of Radix Codonopsis, 25 parts of Rhizoma Coptidis, 25 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s, 25 parts of the Radixs Astragali.

A kind of method for preparing of treating the dyspeptic compound bee-glue composition of dog cat, carry out as follows:

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing propolis 15-35 part, Fructus Aurantii Immaturus 15-45 part, Fructus Schisandrae Chinensis 10-35 part, Radix Pulsatillae 15-40 part by weight, mix 5-10 minute to even;

(3) take by weighing Radix Codonopsis 15-35 part, Rhizoma Coptidis 10-35 part, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10-35 part, Radix Astragali 10-35 part by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is following:

Propolis: bitter, hot, cold, return spleen, lung, stomach warp, have anti-bacteria and anti-virus, antalgesic-antipruritic, promotion tissue regeneration, improve immunity, antiallergic oxidation, stop blooding, moisturize, the function of relieving cough and asthma, protection gastrointestinal mucosa.

Rhizoma Coptidis: bitter, cold, return liver, the heart, spleen, stomach, gallbladder, large intestine channel, have the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly damp-heat dysentery, hyperactivity of heart-fire, excessiveness of stomach-fire, dampness-heat in the liver and gallbladder, conjunctival congestion and swelling pain, fire-toxin carbuncle sore etc.

The Radix Pulsatillae: bitter, cold, return stomach, large intestine channel, have the function of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery; Cure mainly toxic-heat and blood stasis, damp and hot removing heat from blood etc.

The Radix Astragali: sweet, tepor, return spleen, lung meridian, have the function of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Curing mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficultly bursts, bursts for a long time and do not hold back etc.

Fructus Aurantii Immaturus: bitter, cold, return lung, the heart, tri-jiao channel, have the function of eliminating fire and detoxication, clearing away heat and promoting diuresis, removing heat from blood; Cure mainly three warmers intenseness of heat, jaundice due to damp-heat, pyretic stranguria, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, heat in blood epistaxis etc.

Fructus Schisandrae Chinensis: sweet, sour, warm, return lung, kidney, heart channel, have the astringing intestine to stop diarrhea of astringing the lung, a function of the hidroschesis that promotes the production of body fluid, reinforcing the kindey to control nocturnal emission; Cure mainly that the deficiency of the lung is breathed with cough, chronic diarrhea etc.

Radix Codonopsis: sweet, flat, return spleen, lung meridian, have the function of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting; Cure mainly weakness of the spleen and stomach, eat diarrhoea, cough and asthma due to lung deficiency, fatigue and lack of strength, the deficiency of vital energy less and hang down and take off etc.

JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata): sweet, flat, warm, GUIXIN, liver, kidney, large intestine channel have invigorating the spleen and regulating the stomach, the stagnant function of soothing the liverization; Curing mainly food stagnation does not disappear, vomits and have loose bowels etc.

More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, to dyspeptic paathogenic factor of dog cat and clinical symptoms, the effect of performance treating both the principal and secondary aspects of a disease.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, have no side effect, no drug residue, have no drug resistance, and cost is low, and it is wide to draw materials, and micronizing, bioavailability are high, the curative effect highly significant.The present invention optimizes this eight flavors Chinese medicine, and makes them form pure Chinese powder medicine according to optimum ratio according to Chinese veterinarian's traditional theory, and clinical practice proves that treatment dog cat dyspepsia is had specially good effect.

The specific embodiment

Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:

Embodiment 1

Dyspeptic compound bee-glue composition of a kind of treatment dog cat and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing 150 parts of propolis, 150 parts of Fructus Aurantii Immaturuss, 100 parts of Fructus Schisandrae Chinensis, 150 parts of the Radix Pulsatillaes by weight, mix 5-10 minute to even;

(3) take by weighing 150 parts of Radix Codonopsis, 100 parts of Rhizoma Coptidis, 100 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s, 100 parts of the Radixs Astragali by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

Dyspeptic compound bee-glue composition of a kind of treatment dog cat and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing 250 parts of propolis, 300 parts of Fructus Aurantii Immaturuss, 250 parts of Fructus Schisandrae Chinensis, 250 parts of the Radix Pulsatillaes by weight, mix 5-10 minute to even;

(3) take by weighing 250 parts of Radix Codonopsis, 250 parts of Rhizoma Coptidis, 250 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s, 250 parts of the Radixs Astragali by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

Dyspeptic compound bee-glue composition of a kind of treatment dog cat and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing 350 parts of propolis, 450 parts of Fructus Aurantii Immaturuss, 350 parts of Fructus Schisandrae Chinensis, 400 parts of the Radix Pulsatillaes by weight, mix 5-10 minute to even;

(3) take by weighing 350 parts of Radix Codonopsis, 350 parts of Rhizoma Coptidis, 350 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s, 350 parts of the Radixs Astragali by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

With the ill dog cat of product feeding of the present invention etc., a day dose is: irritate clothes or lick and lick 5 grams-10 grams, every day 1-2 time, logotype 3-5 day by per kilogram of body weight of the present invention; Oral back reaches the purpose of treatment disease through gastrointestinal absorption.

Table is the present invention and the applicable cases contrast of the dyspeptic field of other medicines treatment dog cat:

Numbering	Group	Case fatality rate %	Cure rate %	Symptom rate % is arranged during end
					I	The blank group	11.3	73.1	15.6
II	The Fructus Aurantii Immaturus intestinal stasis relieving looses and organizes	7.4	83.7	8.9
					III	Present composition group	3.3	92.5	4.2

This clinical effectiveness is through statistical analysis, and present composition treatment group is loose to organize with the Fructus Aurantii Immaturus intestinal stasis relieving and compared difference extremely significantly (P＜0.01) aspect the cure rate.

Above-mentioned detailed description of dyspeptic compound bee-glue composition of this treatment dog cat and preparation method thereof being carried out with reference to embodiment; Be illustrative rather than determinate; Can enumerate out several embodiment according to institute's limited range; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.

Claims (3)

1. treatment dog cat dyspeptic compound bee-glue composition, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Fructus Aurantii Immaturus 15-45 part, Fructus Schisandrae Chinensis 10-35 part, Radix Pulsatillae 15-40 part, Radix Codonopsis 15-35 part, Rhizoma Coptidis 10-35 part, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10-35 part, Radix Astragali 10-35 part.

2. the dyspeptic compound bee-glue composition of treatment dog cat according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 30 parts of Fructus Aurantii Immaturuss, 25 parts of Fructus Schisandrae Chinensis, 30 parts of the Radix Pulsatillaes, 25 parts of Radix Codonopsis, 25 parts of Rhizoma Coptidis, 25 parts of JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata)s, 25 parts of the Radixs Astragali.

3. the method for preparing of the dyspeptic compound bee-glue composition of treatment according to claim 1 and 2 dog cat is characterized in that carrying out as follows:

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing propolis 15-35 part, Fructus Aurantii Immaturus 15-45 part, Fructus Schisandrae Chinensis 10-35 part, Radix Pulsatillae 15-40 part by weight, mix 5-10 minute to even;

(3) take by weighing Radix Codonopsis 15-35 part, Rhizoma Coptidis 10-35 part, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10-35 part, Radix Astragali 10-35 part by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.