CN104383210A - Medicine for assisting post-hepatectomy recovery - Google Patents
Medicine for assisting post-hepatectomy recovery Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Abstract
The invention discloses a medicine for assisting post-hepatectomy recovery and belongs to the field of traditional Chinese medicine. The medicine is prepared from the following raw materials in parts by weight: 20-30 parts of common andrographis herb, 15-30 parts of pseudo-ginseng, 10-40 parts of donkey-hide gelatin, 5-15 parts of Chinese yam, 30-50 parts of codonopsis pilosula, 5-15 parts of prepared rehmannia root, 30-50 parts of hawthorn, 20-50 parts of fructificatio corioli and 10-20 parts of white paeony root. The medicine for assisting post-hepatectomy recovery aims at dissipating stasis and settling pain, detoxifying and clearing the hollow viscera, activating blood circulation and tonifying qi, and is capable of boosting the immunity, tonifying spleen and promoting the secretion of saliva or body fluid, and tranquilizing mind by nourishing the heart by virtue of treatment determination based on syndrome differentiation for the pathogenesis of liver cancer and liver depression, blood stasis and qi stagnation, liver-kidney yin deficiency, spleen-kidney yang deficiency and the like; the medicine is nourishing but not oily, and warm but not dry, takes the subsequent risks and side effects brought by the liver cancer operations into account, and is remarkable in clinical curative effect and suitable for clinical post-hepatectomy recovery treatment.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly relate to a kind of medicine for hepatic carcinoma excision post-operative recovery.
Background technology
Hepatocarcinoma refers to the malignant tumor betiding liver, comprises primary hepatocarcinoma and secondary liver cancer two kinds, is one of modal malignant tumor clinically, classical symptom is that appetite obviously goes down, upper right abdomen dull pain, weakly to become thin, jaundice, ascites, skin pruritus etc.The Therapeutic Method first operative treatment of current hepatocarcinoma clinically, the object of healing is reached by complete removing tumor tissues, but always there is the risk of recurrence and transfer, and accompany by the problems such as wound infection, weak anemia, pain insomnia and inappetence more, clear-cutting forestland slowly maybe cannot recover.Regular western medicine therapy mostly imposes antibiotic and/or antalgica is treated, and weak curative effect side effect is obvious.The every problem of described Post operation is still lacked at present to the medicine of generally acknowledging the safe and effective Comprehensive Treatment of energy.
Traditional Chinese medical theory is thought, hepatocarcinoma is normally because attacking the impairment of the spleen outside damp, and taste rising tune is lacked of proper care, the retention of water-damp in the body caused by stagnation of QI due to depression of the liver blood stasis, the hepatic and renal YIN deficiency, deficiency of spleen-YANG and kidneyYANG, and general performance is that gas, blood, all void of negative and positive are gentle, blood, expectorant, wet all strongly fragrant.In symptomatic treatment, when based on dissipating blood stasis analgesic therapy, removing toxic substances purging FU-organs, activating blood circulation and supplementing qi, spleen invigorating promote the production of body fluid, tranquilizing by nourishing the heart is auxiliary, reasonable selection medical material prescription concoct.Meanwhile, for obtaining optimum therapeuticing effect, while conditioning liver internal organs, the side effect of operative treatment and the control of cancer metastasis should be taken into account, reaching that strong liver is healthy and strong, the object for the treatment of must aim at the pathogenesis of disease.
Summary of the invention
The invention provides a kind of medicine recovered for auxiliary Post hepatectomy of liver cancer, there is dissipating blood stasis analgesic therapy, effect of the purging FU-organs that detoxifies, QI invigorating of invigorating blood circulation, strengthening spleen, tonifying kidney, nourishing blood to tranquillize the mind, to Post Liuer Cancer Surgery, there is excellent adjuvant treatment effect.
After described Post hepatectomy of liver cancer has specifically referred to hepatic carcinoma resection operation week age.
For solveing the technical problem, reached good therapeutic purposes by determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, the following technical scheme of the invention process:
A kind of medicine recovered for auxiliary Post hepatectomy of liver cancer, raw material composition and the parts by weight of making described medicine are: Herba Andrographis 20 ~ 30 parts, Radix Notoginseng 15 ~ 30 parts, 10 ~ 40 parts, Colla Corii Asini, Rhizoma Dioscoreae 5 ~ 15 parts, Radix Codonopsis 30 ~ 50 parts, Radix Rehmanniae Preparata 5 ~ 15 parts, Fructus Crataegi 30 ~ 50 parts, Ganoderma lucidum seu Japonicum 20 ~ 50 parts, Radix Paeoniae Alba 10 ~ 20 parts.
Preferably, raw material composition and the parts by weight of making described medicine are: Herba Andrographis 25 parts, Radix Notoginseng 25 parts, 30 parts, Colla Corii Asini, Rhizoma Dioscoreae 10 parts, Radix Codonopsis 45 parts, Radix Rehmanniae Preparata 10 parts, Fructus Crataegi 40 parts, Ganoderma lucidum seu Japonicum 30 parts, Radix Paeoniae Alba 15 parts.
The preparation method of described a kind of medicine for auxiliary hepatic carcinoma excision post-operative recovery, comprises the following steps:
(1) get new fresh Fructus Crataegi and Rhizoma Dioscoreae removal impurity, Fructus Crataegi enucleation stalk, Rhizoma Dioscoreae peeling, all section is dried, for subsequent use.
(2) get Radix Codonopsis clean silt after water purification run through reed, section or cutting, dry, wheat bran be placed in the pot of heating, when playing cigarette to pot, add Radix Codonopsis sheet, stir to buff, take out sieve remove wheat bran, cool.Every Radix Codonopsis 100 jin, with 20 jin, wheat bran.
(3) by step (1), the obtained medical material of step (2), same Herba Andrographis, Radix Notoginseng, Radix Rehmanniae Preparata, Ganoderma lucidum seu Japonicum, Radix Paeoniae Alba take by weight ratio, put into marmite or other drug-decocting appliances, add the clean water meeting drinking water standard, 5 times of weight are in put Chinese crude drug, above-mentioned Chinese crude drug is soaked one hour before entering to decoct, make it fully moistening, boil with high heat and use slow fire again instead and decoct, when decocting stopping in 45 minutes, removing medicinal residues, get decoction, for subsequent use.
(4) step (3) gained decoction is reentered in clean drug-decocting appliance, add the clean water meeting drinking water standard, volume is 1/5th of decoction, intense fire boils, take Colla Corii Asini by raw-material weight ratio, smash, add in decoction, wait to dissolve and stir evenly, get this decoction and get final product.
The property of medicine of the present invention's Chinese medicine used is as follows:
Herba Andrographis: bitter in the mouth, cold in nature.GUIXIN, lung, large intestine channel.Heat-clearing and toxic substances removing, pathogenic fire purging dampness.Cure mainly anemopyretic cold; Epidemic febrile disease is generated heat; Cough due to lung-heat; Lung abscess; Laryngopharynx swelling and pain; Jaundice due to damp-heat; Stranguria; Erysipelas; Skin infection carbuncle; Eczema; Venom." Quanzhou book on Chinese herbal medicine " carries: " heat-clearing and toxic substances removing, antiinflammatory detumescent.Control laryngopharyngitis, dysentery, high heat." " modern medicine study confirmation, Herba Andrographis can suppress and delay Diplococcus pneumoniae and the body temperature caused by hemolytic group B streptococcus raises, and reduces oozing out of capillary wall, suppress escherichia coli, improve the ability that peripheral blood leucocyte engulfs staphylococcus aureus, adrenal cortex reinforcing function.
Radix Notoginseng: sweet and slightly bitter taste, warm in nature.Enter liver, stomach, large intestine channel.Hemostasis dissipating blood stasis, subduing swelling and relieving pain.Cure mainly haematemesis, hemoptysis, epistaxis, have blood in stool, dysentery, metrorrhagia, lump in the abdomen, puerperal blood faints, retention of lochia, fall and flutter blood stasis, traumatic hemorrhage, carbuncle pain." detailed outline " carries: " hemostasis, loose blood, analgesic therapy.Gold sword arrow wound, fall and flutter flogging injury, blood goes out more than person, chews rotten painting, or for mixing it in end, namely its blood stop.Also main haematemesis, epistaxis, hematochezia, dysentery, metrorrhagia, incessant menorrhea, puerperal stagnant blood not under, blood transport, blood pain, Akamu, carbuncle, tiger stings, all diseases of snakebite." modern medicine study confirmation; Radix Notoginseng contains the active component of multiple dammarane type four-ring triterpenoid Saponin as ginsenoside, arasaponin, Herb Gynostemmae Pentaphylli glycoside etc.; and the active ingredients such as effective ingredient dencichine, anticancer polyacetylene composition panaxytiol of stopping blooding; coronary artery blood flow can be increased, decreased heart rate, reduce myocardial oxygen consumption; resist because of the blood pressure rising caused by pituitrin, coronary artery contraction; stop blooding, anticancer, the accumulation of promotion white mice liver glycogen.
Radix Codonopsis: sweet in the mouth, property is put down, nontoxic.Return spleen, lung meridian.Invigorating middle warmer, QI invigorating, promotes the production of body fluid.Cure mainly weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis." Bencao Congxin " carries: " invigorating the spleen and replenishing QI, and taste, relieving thirst and restlessness." modern medicine study confirmation; Radix Codonopsis can make maincenter M cholinoceptor density significantly increase; improve the impact of the mouse memory acquired disturbance that Anisodine causes; suppress central nervous system; inhibition thrombosis, obviously antagonism isoproterenol oxygen consumption, the acute myocardial ischemia of protection caused by hypophysis; the quantity of macrophage can be made to increase, phagocytic activity enhancing.
Colla Corii Asini: sweet in the mouth, property is put down.Return liver; Lung; Kidney channel.Enrich blood, hemostasis, YIN nourishing, moisturizes.Cure mainly syndrome of deficiency of blood; Asthenia is spat blood; Spit blood; Hematuria; Have blood in stool; Dysentery; Gestation hemorrhage; Metrorrhagia; The vexed insomnia of the deficiency of YIN; Deficiency of the lung bath is coughed; The convulsion of stirring-up of pathogenic wind in the interior resulting from deficiency is fainted tic." detailed outline " carries: " Colla Corii Asini, will just enrich blood and liquid greatly, therefore can lung heat clearing tonifying YIN and control all cards." modern medicine study confirms, Colla Corii Asini nourishing blood effect is strong, and curative effect is better than chalybeate, can shock, has positive calcium balance effect, and is beneficial to vitamin E absorption.
Rhizoma Dioscoreae: sweet in the mouth, property is put down.Return lung, spleen; Kidney channel.Spleen reinforcing, supports lung, reinforces the kidney, benefit essence.Cure mainly diarrhea due to hypofunction of the spleen; Lack of appetite edema; Cough and asthma due to lung deficiency; Quench one's thirst; Seminal emission; Leukorrhagia; To suffer from a deficiency of the kidney frequent micturition; Carbuncle is controlled in external; Scrofula." ancient Chinese medical classics trace back Hui Ji " carries: " dry Rhizoma Dioscoreae, though solely enter meridian of Hand-TAI YIN, so its merit also can reinforcing YIN-essence, and hands is lunar, and be that foot lacks on the moon former, and former existing taste, flows unhelpful." modern medicine study confirmation; Rhizoma Dioscoreae significantly can reduce the blood glucose of normal mouse and alloxan diabetes mice; regulate body to non-specific irritant reaction; obviously alleviate the infringement of mice organs by anaerobic environment; improve toleration; strengthen the effect of mice carbon clearance, pole resists the Immunosuppression effect of cyclophosphamide effectively.
Radix Rehmanniae Preparata: sweet in the mouth, warm in nature.Return liver, kidney channel.Enrich blood moist, beneficial essence fills out marrow.Cure mainly blood tiger sallow; Dizzy cardiopalmus; Menoxenia; Collapse more than; Hepatic and renal YIN deficiency; Hectic fever night sweat; Seminal emission sexual impotence; Infertility; Soreness of the waist and knees; Hiccough and deaf; The head is dim-sighted; Early whitening of beard and hair; Quench one's thirst; Constipation; To suffer from a deficiency of the kidney dyspnea with rapid and short breath." detailed outline " carries: " fill out bone marrow, longue meat, promoting generation of vital essence and blood, tonifying five ZANG-organs, internal injury are not enough, and promoting blood circulation, sharp knowledge, black beard and hair, man's five kinds of strain and seven kinds of impairment, woman's damaging the spleen and stomach threatened abortion, irregular menorrhea, tire produces all kinds of diseases and ailments." modern medicine study confirms; the effect of Radix Rehmanniae Preparata enriching yin and nourishing kidney is relevant with improving in body aldosterone level in blood plasma; can increase the activity of animal serum Glutathione Peroxidase; reduce the content of lipid peroxide in serum; improve the ratio of albumin and globulin in tumor animal blood, promotion hematopoietic stem cell is to the generation of hemocyte.
Fructus Crataegi: acid is sweet, tepor is nontoxic.Return spleen, stomach, liver, lung meridian.Help digestion long-pending; Change the stagnant stasis of blood.Cure mainly eating accumulation, abdominal distention, dysentery, dysmenorrhea due to blood stasis, amenorrhea, puerperal abdonimal pain; Lochiorrhea." detailed outline " carries: " dissipating fluid-retention is eaten, and the meat that disappears amasss, lump in the abdomen, phlegm retention feeling of fullness acid regurgitation, stagnant blood pain with distension." modern medicine study confirmation; Fructus Crataegi contains lipase; can promote fat digestion; increase the secretion of peptic digestion enzyme, regulates gastrointestinal function, scavenging activated oxygen, suppression mouse liver lipid peroxidation; lower the hyaluronic acid depolymerization of oxygen-derived free radicals through inducing; eliminate the precursor substance of synthesis nitrosamine, i.e. blocking-up synthesis nitrosamine, the remarkable mutagenic action suppressing flavacin.
Ganoderma lucidum seu Japonicum: sour in the mouth, property is put down.Return lung; The heart; Spleen; Kidney channel.Improving eyesight, tonifying liver gas, An Jinghun.Cure mainly asthenia; Cardiopalmus; Insomnia; Dizzy; Spiritlessness and weakness; Chronic cough is panted; Coronary heart disease; Pneumosilicosis; Tumor." herbal classic " carries: " Ganoderma lucidum seu Japonicum, sour in the mouth is put down.Main improving eyesight, tonifying liver gas, An Jinghun, core is pardoned, and eat for a long time, make light of one's life by commiting suicide the angle that always do not prolong life." modern medicine study confirmation; Ganoderma lucidum seu Japonicum obviously can strengthen the central inhibitory action of pentobarbital sodium; the latency of pain response of significant prolongation radiant heat stimulation in rats tail; have obvious analgesic activity; promote the protein of serum, liver and bone marrow and the synthesis of nucleic acid; the division of accelerated bone myelocyte, propagation, protect the liver and improve the function of detoxification of liver, its water extract has inhibitory action to the cattle platelet aggregation that thrombin brings out in vitro, in its mycelium, isolated proteoglycan can strengthen host immune function by tumor host mediation, has and has antitumor action.
Radix Paeoniae Alba: bitter in the mouth, acid, cold nature.Return liver; Spleen channel.Nourish blood and seek; Relieving spasm to stop pain; Yin fluid astringing suppressing the hyperactive liver.Cure mainly menoxenia; Abdominal pain during menstruation; Metrorrhagia; Spontaneous perspiration; Night sweat; Side of body rib epigastric pain; Limb pain twin; Headache; Dizzy." herbal classic " carries " cure mainly pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, cold and heat, hernia abdominal mass, pain relieving, diuresis, QI invigorating." modern medicine study confirm Radix Paeoniae Alba can to adjuvant arthritis rats have antiinflammatory and function dependency ground immunoregulation effect, the phagocytic function of macrophage can be strengthened.
The selected good recipe of the present invention, Radix Rehmanniae Preparata in side, Colla Corii Asini, Radix Notoginseng, Radix Codonopsis, Rhizoma Dioscoreae are compatible, benefiting qi and nourishing blood, righting primordial QI reinforcing; Radix Notoginseng, Radix Rehmanniae Preparata, Fructus Crataegi, the compatible removing blood stasis and activating blood flow of Ganoderma lucidum seu Japonicum, analgesic therapy are calmed the nerves; The product easily impairment of YIN of a specified duration of warm-dryness syndrome, the compatible heat-clearing and toxic substances removing of Radix Paeoniae Alba, Herba Andrographis, Colla Corii Asini, yin fluid astringing are managed jointly, nourshing Yin and drynsessmoistening prescription; Radix Notoginseng, Radix Codonopsis, Radix Rehmanniae Preparata, all medicines of Ganoderma lucidum seu Japonicum are rich in the various bioactivators such as ginsenoside, arasaponin, proteoglycan, energy immunity moderation system, cancer-resisting.The all medicine compatibilities of we, with dissipating blood stasis analgesic therapy, the purging FU-organs that detoxifies, QI invigorating of invigorating blood circulation for aim, for pathogenesis determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs such as initiation hepatocarcinoma stagnation of liver-QI, stagnation of QI and blood, the hepatic and renal YIN deficiency, deficiency of spleen-YANG and kidneyYANG, mend and oiliness, temperature and not dry, spleen invigorating is promoted the production of body fluid, tranquilizing by nourishing the heart, take into account follow-up risk and the side effect such as hepatalgia, wound inflammation heat-clearing and toxic substances removing that operation of liver cancer brings simultaneously, improve immunity, cancer-resisting, suppress transfer, remarkable through clinical efficacy, be suitable for resuming treatment after clinical hepatic carcinoma excision.
Detailed description of the invention
Below in conjunction with embodiment and case, further explaination is done to the present invention.
Embodiment 1
The raw material composition of medicine of the present invention and weight are: Herba Andrographis 6.25 grams, Radix Notoginseng 6.25 grams, 7.5 grams, Colla Corii Asini, Rhizoma Dioscoreae 2.5 grams, Radix Codonopsis 4.5 grams, Radix Rehmanniae Preparata 2.5 grams, Fructus Crataegi 10 grams, Ganoderma lucidum seu Japonicum 7.5 grams, Radix Paeoniae Alba 3 grams.
The preparation method step of medicine of the present invention is:
(1) get new fresh Fructus Crataegi and Rhizoma Dioscoreae removal impurity, Fructus Crataegi enucleation stalk, Rhizoma Dioscoreae peeling, all section is dried, for subsequent use.
(2) get Radix Codonopsis clean silt after water purification run through reed, section or cutting, dry, wheat bran be placed in the pot of heating, when playing cigarette to pot, add Radix Codonopsis sheet, stir to buff, take out sieve remove wheat bran, cool.Every Radix Codonopsis 100 jin, with 20 jin, wheat bran.
(3) by step (1), the obtained medical material of step (2), same Herba Andrographis, Radix Notoginseng, Radix Rehmanniae Preparata, Ganoderma lucidum seu Japonicum, Radix Paeoniae Alba take by weight ratio, put into marmite or other drug-decocting appliances, add the clean water meeting drinking water standard, 5 times of weight are in put Chinese crude drug, above-mentioned Chinese crude drug is soaked one hour before entering to decoct, make it fully moistening, boil with high heat and use slow fire again instead and decoct, when decocting stopping in 45 minutes, removing medicinal residues, get decoction, for subsequent use.
(4) step (3) gained decoction is reentered in clean drug-decocting appliance, add the clean water meeting drinking water standard, volume is 1/5th of decoction, intense fire boils, take Colla Corii Asini by raw-material weight proportioning, smash, add in decoction, wait to dissolve and stir evenly, get this decoction and get final product.
Usage and dosage: adult 500ml every day, sooner or later respectively take 250ml, take for one hour after meal, patient with severe symptoms takes the circumstances into consideration dosage, 15 days is a course for the treatment of, general 2 ~ 3 onsets course for the treatment of.
Embodiment 2
The raw material composition of medicine of the present invention and weight are: Herba Andrographis 4 grams, Radix Notoginseng 3 grams, 8 grams, Colla Corii Asini, Rhizoma Dioscoreae 3 grams, Radix Codonopsis 6 grams, Radix Rehmanniae Preparata 2 grams, Fructus Crataegi 8 grams, Ganoderma lucidum seu Japonicum 8 grams, Radix Paeoniae Alba 4 grams.
The process for preparing medicine step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 3
The raw material composition of medicine of the present invention and weight are: Herba Andrographis 4 grams, Radix Notoginseng 6 grams, 8 grams, Colla Corii Asini, Rhizoma Dioscoreae 1 gram, Radix Codonopsis 10 grams, Radix Rehmanniae Preparata 1 gram, Fructus Crataegi 10 grams, Ganoderma lucidum seu Japonicum 10 grams, Radix Paeoniae Alba 2 grams.
The process for preparing medicine step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 4
The raw material composition of medicine of the present invention and weight are: Herba Andrographis 6 grams, Radix Notoginseng 3 grams, 2 grams, Colla Corii Asini, Rhizoma Dioscoreae 3 grams, Radix Codonopsis 6 grams, Radix Rehmanniae Preparata 3 grams, Fructus Crataegi 6 grams, Ganoderma lucidum seu Japonicum 4 grams, Radix Paeoniae Alba 4 grams.
The process for preparing medicine step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 5
The raw material composition of medicine of the present invention and weight are: Herba Andrographis 4 grams, Radix Notoginseng 3 grams, 2 grams, Colla Corii Asini, Rhizoma Dioscoreae 1 gram, Radix Codonopsis 6 grams, Radix Rehmanniae Preparata 1 gram, Fructus Crataegi 6 grams, Ganoderma lucidum seu Japonicum 4 grams, Radix Paeoniae Alba 2 grams.
The process for preparing medicine step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 6
The raw material composition of medicine of the present invention and weight are: Herba Andrographis 6 grams, Radix Notoginseng 6 grams, 8 grams, Colla Corii Asini, Rhizoma Dioscoreae 3 grams, Radix Codonopsis 10 grams, Radix Rehmanniae Preparata 3 grams, Fructus Crataegi 10 grams, Ganoderma lucidum seu Japonicum 10 grams, Radix Paeoniae Alba 4 grams.
The process for preparing medicine step of the present embodiment and usage and dosage identical with embodiment 1.
Embodiment 7
The raw material composition of medicine of the present invention and weight are: Herba Andrographis 4.4 grams, Radix Notoginseng 5.2 grams, 2.8 grams, Colla Corii Asini, Rhizoma Dioscoreae 2.8 grams, Radix Codonopsis 6.4 grams, Radix Rehmanniae Preparata 1.6 grams, Fructus Crataegi 7.2 grams, Ganoderma lucidum seu Japonicum 4.8 grams, Radix Paeoniae Alba 2.4 grams.
The process for preparing medicine step of the present embodiment and usage and dosage identical with embodiment 1.
Clinical data and case:
For inspection curative effect of the present invention, choose the patient that 500 examples carry out Post hepatectomy of liver cancer, wherein male 39 example, women 11 example, age 36-67 year, 49 years old mean age.
Choice criteria: limb is soft weak; Poor appetite, abdominal distention; Face is sallow; Hepatalgia; Energy is not good; Liver function transaminase disorder, carcinoembryonic antigen is abnormal, and other index is as carbohydrate antigen, and squamouse cell carcinoma antigen, alpha-fetoprotein etc. are abnormal.As above symptom, can make a definite diagnosis.
Efficacy determination:
Remarkable: weak alleviation; Poor appetite, abdominal distention, hepatalgia are alleviated, and hepatic region is comfortable; Hepatic face is taken on a new look to some extent, of pink and healthy-looking; Liver function test transaminase, plasma albumin target improvement, carcinoembryonic antigen, alpha-fetoprotein index is obviously improved or normally.
Alleviate: weakly to alleviate; Poor appetite, pain relief; The state of an illness obtains part and controls; The part index numbers such as carcinoembryonic antigen make moderate progress.
Invalid: clinical symptoms is without being clearly better or increasing the weight of.
Treatment group is taken Chinese medicine of the present invention continuously and is coordinated regular western medicine therapy for treating, and blank group adopts placebo to treat with identical western medicine therapy, and after four months, observe the change of conditions of patients, therapeutic outcome is as follows:
| Group | Number | Significantly | Alleviate | Invalid | Total effective rate |
| Treatment group | 35 | 50(20％) | 164(57.14％) | 36(14.29％) | 85.71％ |
| Blank group | 15 | 17(6.6％) | 50(20％) | 183(73.33％) | 26.67％ |
Below by concrete case, further checking is done to Chinese medicine composition curative effect provided by the invention.
Xu certain, female, 53 years old, on April 13rd, 2011 carried out liver resection, and after performing the operation one week, epigastrium pain, abdominal distention, poor appetite, dim complexion, weak pulse is thin.Taking medicine of the present invention coordinates regular western medicine to treat.After one month, appetite is clearly better, pain relief, and carcinoembryonic antigen index starts to make moderate progress.After continuing to take four months, stomachache is not done, and all diseases alleviate, and indices all has clear improvement.
Liu so-and-so, man, 36 years old, in JIUYUE, 2012 was diagnosed as primary hepatocarcinoma, and in carrying out liver resection October 5 then, after performing the operation one week, hepatalgia, shallow complexion, weak body is tired.Taking medicine of the present invention coordinates regular western medicine to treat.Hepatic region is only after a course for the treatment of, and distending pain is aobvious to be subtracted, and spiritual amelioration, complexion also takes a turn for the better, and alpha-fetoprotein index obviously reduces.Take medicine of the present invention after two months, except paddy third turn of ammonia and glutamic oxaloacetic transaminase, GOT index slightly height, all the other indexs all recover normal.Patient adheres to taking medicine the time more than a year, has no significant discomfort, has rosy cheeks, general with mediocrity.
Claims (2)
1. for the medicine that auxiliary Post hepatectomy of liver cancer recovers, it is characterized in that: raw material composition and the parts by weight of making described medicine are: Herba Andrographis 20 ~ 30 parts, Radix Notoginseng 15 ~ 30 parts, 10 ~ 40 parts, Colla Corii Asini, Rhizoma Dioscoreae 5 ~ 15 parts, Radix Codonopsis 30 ~ 50 parts, Radix Rehmanniae Preparata 5 ~ 15 parts, Fructus Crataegi 30 ~ 50 parts, Ganoderma lucidum seu Japonicum 20 ~ 50 parts, Radix Paeoniae Alba 10 ~ 20 parts.
2. a kind of medicine recovered for auxiliary Post hepatectomy of liver cancer according to claim 1, is characterized in that: raw material composition and the parts by weight of making described medicine are: Herba Andrographis 25 parts, Radix Notoginseng 25 parts, 30 parts, Colla Corii Asini, Rhizoma Dioscoreae 10 parts, Radix Codonopsis 45 parts, Radix Rehmanniae Preparata 10 parts, Fructus Crataegi 40 parts, Ganoderma lucidum seu Japonicum 30 parts, Radix Paeoniae Alba 15 parts.
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| CN101850022A (en) * | 2009-11-25 | 2010-10-06 | 北京绿源求证科技发展有限责任公司 | Anti-infective Chinese medicament |
| CN102836191A (en) * | 2011-06-24 | 2012-12-26 | 绵阳市星光微生物研究所 | Green lucid ganoderma traditional Chinese drug composition and preparation method thereof |
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Application publication date: 20150304 |