CN108936623A - Double protein gastric cancer full nutrition formula food and preparation method thereof - Google Patents

Double protein gastric cancer full nutrition formula food and preparation method thereof Download PDF

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Publication number
CN108936623A
CN108936623A CN201810820029.2A CN201810820029A CN108936623A CN 108936623 A CN108936623 A CN 108936623A CN 201810820029 A CN201810820029 A CN 201810820029A CN 108936623 A CN108936623 A CN 108936623A
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vitamin
raw material
calcium
gastric cancer
protein
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Inventor
周泉城
于婷
陈慧民
任元海
李慧
孙明红
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Shandong Sheng Hai Health Product Co Ltd
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Shandong Sheng Hai Health Product Co Ltd
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115Fatty acids or derivatives thereof; Fats or oils
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/125Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/13Nucleic acids or derivatives thereof
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15Vitamins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15Vitamins
    • A23L33/155Vitamins A or D
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16Inorganic salts, minerals or trace elements
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/175Amino acids
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/185Vegetable proteins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/19Dairy proteins
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    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21Addition of substantially indigestible substances, e.g. dietary fibres
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The invention belongs to technical field of nutritional food, and in particular to a kind of double protein gastric cancer full nutrition formula food and preparation method thereof.Contain albumen, fat, carbohydrate, vitamin, minerals, glutamine, branched-chain amino acid, EPA, genistein derivative, nucleotide nutrient element in the double protein gastric cancer full nutrition formula food.The combination of animals and plants double protein in the present invention not only improves flavor, character and the quality of product, also reduces cost.The present invention can provide sufficient, comprehensive nutrition for body, enhance the barrier function of stomach lining, be conducive to body protein synthesis and Metabolism regulation, and stomach function and form is promoted to restore.

Description

Double protein gastric cancer full nutrition formula food and preparation method thereof
Technical field
The invention belongs to technical field of nutritional food, and in particular to a kind of double protein gastric cancer full nutrition formula food and its system Preparation Method.
Background technique
Double protein is that a kind of nutrition is balanced, is easy to the novel protein of absorption.With the proposition of double protein strategy, China is honest Push the healthy product that wide animal protein and vegetable protein combine.Currently, double protein in dairy products using more, but In special medical full nutrition formula food using less.Two kinds of animal/vegetable proteins are mutually compound, the two can be made to take length mutually Mend it is short, battalion value significantly improving, be supplement nutrient protein health selection, the flavor and state of product are improved, so that product Nutrition is comprehensive, bright characteristic.
Show that gastric cancer is as Digestive according to the statistics of the World Health Organization and China's tumour registration annual report data in 2012 The system highest malignant tumour of disease incidence, disease incidence occupy the 2nd, and the death rate occupies the 3rd.2012, China's mortality of gastric carcinoma 32.5 ten thousand people of case, the death rate are 21.9/10 ten thousand.
Patients with gastric cancer is mostly with different degrees of malnutrition or immune dysfunction, especially implementation radical operation for carcinoma of stomach Patient, it is postoperative to be influenced easily to lead to nutritional deficiency by factors such as fasting, gastrointestinal decompressions.And dietetic nutrition is to sustain life, protect The material base of health is held, largely diet has important influence to the function and state of body.Low-income earner or warp Ji situation is not good enough person is because economic capability is limited, in the case where that can not use more efficient treatment means and drug condition, with greater need for abundance Nutrition assurance cope with long-term treatment or rehabilitation.And currently, the full nutrition reasonable, competitively priced for patients with gastric cancer nutrition Formula food is fewer and fewer.Therefore, developing a kind of double protein gastric cancer full nutrition formula food has great economic benefit and society It can meaning.
Summary of the invention
The object of the present invention is to provide a kind of double protein gastric cancer full nutrition formula foods, can provide for body sufficient, complete The nutrition in face enhances the barrier function of stomach lining, is conducive to body protein synthesis and Metabolism regulation, promotes stomach function and shape State is restored;Present invention simultaneously provides preparation methods.
Double protein gastric cancer full nutrition formula food of the present invention, nutritional ingredient is such as in every hectogram full nutrition formula food Under: albumen 33.5-58.3g, fat 1.3-4g, carbohydrate 34.4-60.4g, vitamin A 168-800 μ g, vitamin D 5-13 μ g, vitamin E 1.5-5mg, vitamin K118-185 μ g, vitamin B10.33-1mg, vitamin B2 0.35-1mg、 Vitamin B60.36-1mg, vitamin B120.5-20 μ g, niacin 0.83-8.9mg, folic acid 88-938 μ g, pantothenic acid 1.16- 20mg, vitamin C 2-7mg, biotin 8.3-85 μ g, sodium 45-60mg, potassium 85-145mg, copper 182-230 μ g, magnesium 73- 100mg, iron 3.3-9.4mg, zinc 1.7-8.5mg, manganese 0.099-1.2mg, calcium 215-222mg, phosphorus 159-164mg, iodine 25-50 μ G, selenium 13-91 μ g, chromium 7-28 μ g, glutamine 18-65mg, branched-chain amino acid 70-156mg, EPA 20-50mg, genistein Derivative 25-35mg, nucleotide 100-160mg.
Wherein:
The raw material of albumen is selected from the double protein of pea protein and lactalbumin composition;
The raw material of fat is selected from one of edible vegetable oil or a variety of;It is preferred that soybean oil, rapeseed oil, peanut oil, corn One of oil, safflower oil or Purple Perilla Seed Oil are a variety of;
It is fine that the raw material of carbohydrate is selected from fructose, antierythrite, laminarin, maltodextrin, hydroxypropul starch, diet One of dimension or resistant starch are a variety of;The preferred pea dietary fiber of dietary fiber, the preferred pea resistant starch of resistant starch.
The raw material of vitamin A is selected from one of retinol acetate, retinyl palmitate or beta carotene or a variety of;
The raw material of vitamin D is selected from vitamin D2Or vitamin D3One or both of;
The raw material of vitamin E is in D- alpha-tocotrienol, dl- alpha-tocotrienol or VE succinic acid calcium It is one or more;The preferred dl- α-tocopherol acetate trienol of dl- alpha-tocotrienol;
Vitamin B1Raw material be selected from one or both of thiamine hydrochloride or Thiamin mononitrate;
Vitamin B2Raw material be selected from one or both of riboflavin or riboflavin 5 '-sodium phosphate;
Vitamin B6Raw material be selected from puridoxine hydrochloride;
Vitamin B12Raw material be selected from cyanocobalamin;
The raw material of niacin is selected from one or both of niacin or niacinamide;
The raw material of pantothenic acid is selected from D-VB5 calcium;
Ascorbic raw material is selected from L-AA, L-AA sodium, L-AA calcium or vitamin-c palmitate One of ester is a variety of;
The raw material of biotin is selected from D-Biotin.
The raw material of sodium is selected from sodium chloride;
The raw material of potassium is selected from one of dipotassium hydrogen phosphate, potassium dihydrogen phosphate, potassium chloride or potassium citrate or a variety of;
The raw material of copper is selected from one or both of copper sulphate or copper gluconate;
The raw material of magnesium is selected from one of magnesium carbonate, magnesium sulfate, magnesia, magnesium chloride or L- magnesium threonate or a variety of;
The raw material of iron is in ferrous gluconate, ferrous fumarate, ferrous sulfate, ferrous lactate or ferrous succinate It is one or more;
The raw material of zinc is selected from one of zinc sulfate, zinc citrate, zinc gluconate, zinc oxide or zinc lactate or a variety of;
The raw material of manganese is selected from one or both of manganese sulfate or manganese gluconate;
The raw material of calcium be selected from calcium carbonate, calcium acetate, calcium chloride, calcium citrate, calcium gluconate, calcium lactate, calcium monohydrogen phosphate, One of calcium dihydrogen phosphate, tricalcium phosphate, calcium sulfate, L-calcium lactate or calcium glycerophosphate are a variety of;
The raw material of phosphorus is selected from potassium dihydrogen phosphate;
The raw material of iodine is selected from Potassiumiodate;
The raw material of selenium is selected from one of sodium selenite, Se-enriched yeast or L- selenium-methyl selenium substituted aminothiopropionic or a variety of;
The raw material of chromium is selected from chromium chloride.
Double protein of the present invention the preparation method comprises the following steps: pea protein is mixed with lactalbumin 1:1-1.1 in mass ratio, formed Material, material obtain double protein after pulverizing technique, micronized process.
Wherein: pulverizing technique are as follows: in stream pressure be 0.70-1.0MPa, gas flow temperature is 10-15 DEG C of condition Under, it is 5-8 by crushing material to granularity that the variable-frequency motor revolving speed for controlling air-stream type ultrafine pulverizer, which is 14500-16500r/min, μm protein powder;
Micronized technique are as follows: protein powder is made into the protein dispersion that concentration is 0.08-0.12g/mL, at 85-95 DEG C After humid heat treatment 25-35min, uses revolving speed to emulsify cutter for the high speed of 10000-15000r/min and handle 2-5min.
Genistein derivative of the present invention the preparation method comprises the following steps: by 1mmol genistein, 25mL dehydrated alcohol, 0.08mL After 37% formaldehyde, 1mmoL 1- (2,4- 3,5-dimethylphenyl) piperazine dissolve by heating, reaction is stirred at room temperature, uses thin-layered chromatography (TLC) degree of monitoring reaction, after reaction by recrystallization and silica gel column chromatography, the crystal for isolating and purifying precipitation is to contaminate Expect modified lignin.
Double protein gastric cancer full nutrition formula food of the present invention the preparation method is as follows: with the full nutrition of double protein gastric cancer 100 grams of formula food quality meters, by albumen, carbohydrate, vitamin A, vitamin D, vitamin E, vitamin K1, vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacin, folic acid, pantothenic acid, vitamin C, biotin, sodium, potassium, copper, magnesium, iron, zinc, Manganese, calcium, phosphorus, iodine, selenium, chromium, glutamine, branched-chain amino acid, EPA, genistein derivative, nucleotide nutrient ingredient raw material After sterilizing, 5 parts are divided into, forms function bag;
After the raw material sterilizing of lipid nutrition ingredient, 5 parts are divided into, energy bag is formed.
Wherein: sterilizing power is 425-500W, sterilization time 100-120s.
The eating method of double protein gastric cancer full nutrition formula food of the present invention is as follows:
The age of target group is 18-64 years old, does not include pregnant woman and breast feeding women;
Dosage are as follows: 0.4 bag/(kgd), total amount is no more than 27 bags;
It is edible according to one of following two method:
(1) it is cooled to 40-60 DEG C with the boiled water of 100-200mL, the nutriment in function bag and energy bag is added, stirs After mixing, shaking up, directly drinks or taken in through tube feed;
(2) nutriment in function bag is added in the diet without containing salt and is eaten, contained in diet Some fat is consistent with the fat content in energy bag.
The marketing method of product of the present invention is to be distributed directly to consumer, by the places such as hospital, supermarket or pharmacy or The characteristics of approach is cut down the number of intermediate links, and is reduced expense, is realized low price sale with small profits, the food that consumer can be more economical, more economical With meeting the edible requirement of long term consumer.
Beneficial effects of the present invention are as follows:
The effect of double protein gastric cancer full nutrition formula food of the present invention depends on each self-applying and to each other of nutritional ingredient Synergistic effect.
In the present invention, lactalbumin is good protein, contains beta lactoglobulin, α-lactalbumin, immunoglobulin etc. A variety of active ingredients;Fat, the content of lactose are low in lactalbumin, and saturated fat that more other animal protein contain, gallbladder are solid The harmful substances such as alcohol are few, it is necessary to which amino acid classes and content are complete, and nutritive value is high, is easily digested absorption, can enhance immune, energy Prevent blood lipid and cholesterol from increasing, it is beneficial to cardiovascular disease.
Compared with animal protein, pea protein has reduction cholesterol, prevents cardiovascular disease, is antitumor, reducing kidney The effects of disease incidence, is more advantageous to human health.Glutamic acid rich in, arginine, are respectively provided with muscle in pea protein Restore the effect with cardiovascular disease prevention.In addition, pea protein is cheap, but its mouthfeel is bad, has fishy smell, and molten Solution property is bad.Lactalbumin has the advantages that mouthfeel is good, dissolubility is good, but its price is higher.Pea protein is used in formula With the form of lactalbumin double protein, both vegetable protein and animal protein advantage are combined, avoids the deficiency of single albumen, Cost of material is reduced again.
Importantly, the absorbability of lactalbumin is stronger than pea protein, and lactalbumin is easier to send out compared to pea protein Raw carbonylation, carbonylation will affect the structure and function of protein, to influence the color of product, flavor, physics and chemistry Quality and functional characteristic.In order to avoid carbonylation occurs for lactalbumin, the present invention is double using pea protein and lactalbumin The compound form of albumen, by adding pea protein, when so that carbonylation occurring for lactalbumin in following process, pea egg It is white that lactalbumin is played a certain protective role.
Pea protein and lactalbumin improve specific surface area, surface energy and the hole of protein body after pulverizing Rate, to increase the contact area of protein body and oil, oil absorption is significantly improved.Ultramicro grinding leads to active site of protein hydrophobic group Group's exposure, the enhancing of albumen hydrophobicity, emulsibility and emulsion stability improve;Simultaneously segment it is flexible increase and hydrophobic grouping, The abundant exposure of polar group and-SH increases the foaming characteristic and foam stability of albumen.Therefore, the present invention utilizes Ultramicro-powder Broken process pea protein and lactalbumin, so that double protein has better functional character and dissolubility.
The raw material of fat is selected from rich in the soybean oil, rapeseed oil, peanut oil, corn oil, red based on unsaturated fatty acid One of caul-fat or Purple Perilla Seed Oil are a variety of, are aided with omega-3 polyunsaturated fatty acids, EPA etc..This collocation can sufficiently be sent out Waving omega-3 polyunsaturated fatty acids improves membrane structure, improves cell membrane transport and immune function, promotes T lymphocyte immune Mature effect;Addition nucleotide participates in all activities of internal cell, increases lymphocytes in blood number, and enhancing lymph is thin Born of the same parents' function improves the body immunity of eater;In addition, these oil by it is reasonably combined it is cheap, be easy to get, fatty acid Composition meets specific medical food requirement.
Antierythrite can improve the mouthfeel of diet, improve the appetite of patient, and reducing chemotherapy influences the anorexia of patient, food The depressed mood of patient can be improved after, while combining adjusting stomach with pea dietary fiber, resistant starch, reduce chemotherapy The problems such as bring defecation is unsmooth.Hydroxypropul starch is good suspending agent, and suspending effect is good, does not glue wall, easily disperses, flocculation Grain is fine and smooth.Maltodextrin has good dissolubility, can improve the mobility of product.
Glutamine has significant auxiliary therapeutic action to chemotherapy of gastric cancer patient, while can reduce the side effect of chemotherapy.It is logical Too strong inoxidizability selective clearing free radical, reservation can have the superoxide ion of killing effect certainly to stomach cancer cell from the root By base, in addition, oxidative stress status is adjusted, can also to improve ADA, GSH in Plasma of Patient With Gastric Cancer, PX, CAT, SOD, The expression of MDA, so that the physical condition of patient is adjusted, the deterioration or recurrence for being conducive to the rehabilitation of patient, avoiding disease.
EPA can enhance parenteral absorption, improve the immune function of late gastric cancer patients undergoing chemotherapy, protect the immune of stomach lining Barrier, effect are obvious;Branched-chain amino acid is conducive to maintain the nutrition condition of patient, reduces complication rate, improves patient's Compliance is treated, its quality of life can be improved compared with unsupplemented patient.Genistein derivative itself, which has, inhibits stomach to burst The effect of ulcer and stomach cancer cell, addition genistein derivative is conducive to assist in the treatment of stomach cancer in product.
High protein of the present invention, low fat formula meet gastric cancer eater's physical feature, are conducive to physical rehabilitation.Of the invention Nutraceutical for body other than it can provide sufficient, comprehensive nutrition, it is often more important that enhance the barrier function of stomach lining, more Meet metabolic physiology state, be conducive to body protein synthesis and Metabolism regulation, promotes stomach function and form to restore, prevent bacterium With toxin transposition, hence it is evident that the generation for reducing stomach source sexuality dye is the effective means for improving patients undergoing chemotherapy nutrition condition.The present invention couple The nutrition condition of advanced gastric carcinoma patients undergoing chemotherapy can play certain improvement result, reduce patient's adverse reaction, can effectively mention The immunity of high patient.In addition, in the present invention animals and plants double protein combination, not only improve flavor, character and the product of product Matter also reduces cost, also is compliant with the policy of the new and old kinetic energy conversion of country.
Specific embodiment
The present invention is described further with reference to embodiments.
Embodiment 1
Nutritional ingredient is as follows in every hectogram double protein gastric cancer full nutrition formula food: protein 42 g, fat 4g, carbon hydrate Object 51.5g, 240.79 μ g of vitamin A, 5 μ g of vitamin D, vitamin E 1.6mg, vitamin K119 μ g, vitamin B1 0.4mg, vitamin B20.5mg, vitamin B60.6mg, vitamin B121 μ g, niacin 0.95mg, 325 μ g of folic acid, pantothenic acid 10.8mg, vitamin C 3mg, 85 μ g of biotin, sodium 53.07mg, potassium 99.41mg, 200 μ g of copper, magnesium 73.2mg, iron 4.28mg, Zinc 5.2mg, manganese 0.65mg, calcium 216mg, phosphorus 160.01mg, 29.67 μ g of iodine, 24.2 μ g of selenium, 7.82 μ g of chromium, glutamine 18mg, Branched-chain amino acid 70mg, EPA 20mg, genistein derivative 25mg, nucleotide 100mg.
The raw material for preparing every hectogram full nutrition formula food is as follows:
It is double protein 42g, soybean oil 1g, safflower oil 3g, fructose 30g, pea dietary fiber 10g, hydroxypropul starch 10g, red Moss sugar alcohol 1.5g, 240.79 μ g of retinol acetate, vitamin D25 μ g, D- alpha-tocotrienol 1.6mg, vitamin K1 19μg、 400 μ g of thiamine hydrochloride, 500 μ g of riboflavin, 600 μ g of puridoxine hydrochloride, 1 μ g of cyanocobalamin, 950 μ g of niacin, 325 μ g of folic acid, D- Calcium pantothenate 23.47mg, L-AA 3mg, 85 μ g of D-Biotin, sodium chloride 135mg, potassium citrate 260mg, copper sulphate 502.39 μ g, magnesia 122mg, ferrous fumarate 13mg, zinc oxide 6.47mg, manganese sulfate 1.78mg, calcium citrate 895mg, Potassium dihydrogen phosphate 703mg, 50 μ g of Potassiumiodate, 53 μ g of sodium selenite, 40 μ g of chromium chloride, glutamine 18mg, branched-chain amino acid 70mg, EPA 20mg, genistein derivative 25mg, nucleotide 100mg.
Wherein:
Double protein the preparation method comprises the following steps: 20g pea protein is mixed with 22g lactalbumin, material is formed, in stream pressure For 1.0MPa, under conditions of gas flow temperature is 15 DEG C, the variable-frequency motor revolving speed for controlling air-stream type ultrafine pulverizer is 16500r/ Min, the protein powder for being 8 μm by crushing material to granularity;Protein powder is made into the protein dispersion that concentration is 0.10g/mL, After 90 DEG C of humid heat treatment 30min, uses revolving speed to emulsify cutter for the high speed of 15000r/min and handle 2min, obtain egg-pair It is white.
Genistein derivative the preparation method comprises the following steps: by 1mmol genistein, 25mL dehydrated alcohol, 37% first of 0.08mL After aldehyde, 1mmoL 1- (2,4- 3,5-dimethylphenyl) piperazine dissolve by heating, reaction is stirred at room temperature, is monitored with thin-layered chromatography (TLC) The degree of reaction, after reaction by recrystallization and silica gel column chromatography, the crystal for isolating and purifying precipitation is that genistein spreads out Biology.
The preparation method is as follows:
By double protein, fructose, dietary fiber, hydroxypropul starch, antierythrite, retinol acetate, vitamin D2, D- α-life Educate trienol, vitamin K1, thiamine hydrochloride, riboflavin, puridoxine hydrochloride, cyanocobalamin, niacin, folic acid, D-VB5 calcium, L- it is anti- Bad hematic acid, D-Biotin, sodium chloride, potassium citrate, copper sulphate, magnesia, ferrous fumarate, zinc oxide, manganese sulfate, citric acid Calcium, potassium dihydrogen phosphate, Potassiumiodate, sodium selenite, chromium chloride, glutamine, branched-chain amino acid, EPA, genistein derivative, Nucleotide, sterilize 100s in the sterilizer of 500W, after sterilizing, is divided into 5 parts, forms function bag;
Soybean oil, safflower oil are sterilized 100s in the sterilizer of 500W, after sterilizing, 5 parts is divided into, forms energy Bag.
Embodiment 2
Nutritional ingredient is as follows in every hectogram double protein gastric cancer full nutrition formula food: albumen 40g, fat 2g, carbon hydrate Object 55g, 287.79 μ g of vitamin A, 10 μ g of vitamin D, vitamin E 1.5mg, vitamin K125 μ g, vitamin B1 0.45mg, vitamin B20.6mg, vitamin B60.6mg, vitamin B120.5 μ g, niacin 1mg, 200 μ g of folic acid, pantothenic acid 2.52mg, vitamin C 5mg, 19 μ g of biotin, sodium 56.61mg, potassium 108.6mg, 190.31 μ g of copper, magnesium 80mg, iron 4.28mg, Zinc 7.43mg, 100.13 μ g of manganese, calcium 216mg, phosphorus 160.01mg, 35.604 μ g of iodine, 45.7 μ g of selenium, 16.42 μ g of chromium, glutamine 65mg, branched-chain amino acid 156mg, EPA 50mg, genistein derivative 35mg, nucleotide 160mg.
The raw material for preparing every hectogram full nutrition formula food is as follows:
Double protein 40g, Purple Perilla Seed Oil 1g, corn oil 1g, fructose 10g, pea dietary fiber 10g, laminarin 5g, hydroxypropyl Base starch 10g, pea resistant starch 10g, antierythrite 10g, 287.79 μ g of retinyl palmitate, vitamin D3 10μg、dl- α-tocopherol acetate trienol 6mg, vitamin K125 μ g, 450 μ g of Thiamin mononitrate, 600 μ g of riboflavin, 600 μ of puridoxine hydrochloride G, 0.5 μ g of cyanocobalamin, 1000 μ g of niacin, 200 μ g of folic acid, D-VB5 calcium 5.47mg, ascorbyl palmitate 5mg, D- biology 19 μ g of element, sodium chloride 144mg, potassium citrate 284mg, copper gluconate 1.35mg, magnesium sulfate 396.16mg, ferrous fumarate 13mg, zinc lactate 27.67mg, 275.21 μ g of manganese sulfate, L-calcium lactate 1661mg, potassium dihydrogen phosphate 703mg, 60 μ g of Potassiumiodate, 100 μ g of sodium selenite, 84 μ g of chromium chloride, glutamine 65mg, branched-chain amino acid 156mg, EPA 50mg, genistein derivative 35mg, nucleotide 160mg.
Wherein:
Double protein the preparation method comprises the following steps: 20g pea protein is mixed with 20g lactalbumin, material is formed, in stream pressure For 0.7MPa, under conditions of gas flow temperature is 10 DEG C, the variable-frequency motor revolving speed for controlling air-stream type ultrafine pulverizer is 14500r/ Min, the protein powder for being 5 μm by crushing material to granularity;Protein powder is made into the protein dispersion that concentration is 0.12g/mL, After 95 DEG C of humid heat treatment 35min, uses revolving speed to emulsify cutter for the high speed of 10000r/min and handle 5min, obtain egg-pair It is white.
Genistein derivative the preparation method comprises the following steps: by 1mmol genistein, 25mL dehydrated alcohol, 37% first of 0.08mL After aldehyde, 1mmoL 1- (2,4- 3,5-dimethylphenyl) piperazine dissolve by heating, reaction is stirred at room temperature, is monitored with thin-layered chromatography (TLC) The degree of reaction, after reaction by recrystallization and silica gel column chromatography, the crystal for isolating and purifying precipitation is that genistein spreads out Biology.
The preparation method is as follows:
By double protein, fructose, pea dietary fiber, laminarin, hydroxypropul starch, pea resistant starch, antierythrite, Retinyl palmitate, vitamin D3, dl- α-tocopherol acetate trienol, vitamin K1, Thiamin mononitrate, riboflavin, hydrochloric acid pyrrole tremble Alcohol, cyanocobalamin, niacin, folic acid, D-VB5 calcium, ascorbyl palmitate, D-Biotin, sodium chloride, potassium citrate, glucose Sour copper, magnesium sulfate, ferrous fumarate, zinc lactate, manganese sulfate, L-calcium lactate, potassium dihydrogen phosphate, Potassiumiodate, sodium selenite, chlorination Chromium, glutamine, branched-chain amino acid, EPA, genistein derivative, nucleotide, sterilize 100s in the sterilizer of 500W, goes out After bacterium, 5 parts are divided into, forms function bag;
Purple Perilla Seed Oil, corn oil are sterilized 100s in the sterilizer of 500W, after sterilizing, 5 parts is divided into, forms energy Bag.

Claims (10)

1. a kind of double protein gastric cancer full nutrition formula food, it is characterised in that nutritional ingredient is such as in every hectogram full nutrition formula food Under: albumen 33.5-58.3g, fat 1.3-4g, carbohydrate 34.4-60.4g, vitamin A 168-800 μ g, vitamin D 5-13 μ g, vitamin E 1.5-5mg, vitamin K118-185 μ g, vitamin B10.33-1mg, vitamin B2 0.35-1mg、 Vitamin B60.36-1mg, vitamin B120.5-20 μ g, niacin 0.83-8.9mg, folic acid 88-938 μ g, pantothenic acid 1.16- 20mg, vitamin C 2-7mg, biotin 8.3-85 μ g, sodium 45-60mg, potassium 85-145mg, copper 182-230 μ g, magnesium 73- 100mg, iron 3.3-9.4mg, zinc 1.7-8.5mg, manganese 0.099-1.2mg, calcium 215-222mg, phosphorus 159-164mg, iodine 25-50 μ G, selenium 13-91 μ g, chromium 7-28 μ g, glutamine 18-65mg, branched-chain amino acid 70-156mg, EPA 20-50mg, genistein Derivative 25-35mg, nucleotide 100-160mg.
2. double protein gastric cancer full nutrition formula food according to claim 1, it is characterised in that:
The raw material of albumen is selected from the double protein of pea protein and lactalbumin composition;
The raw material of fat is selected from one of edible vegetable oil or a variety of;
The raw material of carbohydrate be selected from fructose, antierythrite, laminarin, maltodextrin, hydroxypropul starch, dietary fiber or One of resistant starch is a variety of.
3. double protein gastric cancer full nutrition formula food according to claim 1, it is characterised in that:
The raw material of vitamin A is selected from one of retinol acetate, retinyl palmitate or beta carotene or a variety of;
The raw material of vitamin D is selected from vitamin D2Or vitamin D3One or both of;
The raw material of vitamin E is selected from one of D- alpha-tocotrienol, dl- alpha-tocotrienol or VE succinic acid calcium Or it is a variety of;
Vitamin B1Raw material be selected from one or both of thiamine hydrochloride or Thiamin mononitrate;
Vitamin B2Raw material be selected from one or both of riboflavin or riboflavin 5 '-sodium phosphate;
Vitamin B6Raw material be selected from puridoxine hydrochloride;
Vitamin B12Raw material be selected from cyanocobalamin;
The raw material of niacin is selected from one or both of niacin or niacinamide;
The raw material of pantothenic acid is selected from D-VB5 calcium;
Ascorbic raw material is in L-AA, L-AA sodium, L-AA calcium or ascorbyl palmitate It is one or more;
The raw material of biotin is selected from D-Biotin.
4. double protein gastric cancer full nutrition formula food according to claim 1, it is characterised in that:
The raw material of sodium is selected from sodium chloride;
The raw material of potassium is selected from one of dipotassium hydrogen phosphate, potassium dihydrogen phosphate, potassium chloride or potassium citrate or a variety of;
The raw material of copper is selected from one or both of copper sulphate or copper gluconate;
The raw material of magnesium is selected from one of magnesium carbonate, magnesium sulfate, magnesia, magnesium chloride or L- magnesium threonate or a variety of;
The raw material of iron is selected from one of ferrous gluconate, ferrous fumarate, ferrous sulfate, ferrous lactate or ferrous succinate Or it is a variety of;
The raw material of zinc is selected from one of zinc sulfate, zinc citrate, zinc gluconate, zinc oxide or zinc lactate or a variety of;
The raw material of manganese is selected from one or both of manganese sulfate or manganese gluconate;
The raw material of calcium is selected from calcium carbonate, calcium acetate, calcium chloride, calcium citrate, calcium gluconate, calcium lactate, calcium monohydrogen phosphate, phosphoric acid One of calcium dihydrogen, tricalcium phosphate, calcium sulfate, L-calcium lactate or calcium glycerophosphate are a variety of;
The raw material of phosphorus is selected from potassium dihydrogen phosphate;
The raw material of iodine is selected from Potassiumiodate;
The raw material of selenium is selected from one of sodium selenite, Se-enriched yeast or L- selenium-methyl selenium substituted aminothiopropionic or a variety of;
The raw material of chromium is selected from chromium chloride.
5. double protein gastric cancer full nutrition formula food according to claim 2, it is characterised in that: the preparation method of double protein Are as follows: pea protein is mixed with lactalbumin 1:1-1.1 in mass ratio, forms material, material is through pulverizing technique, micronized Double protein is obtained after process.
6. double protein gastric cancer full nutrition formula food according to claim 5, it is characterised in that:
Pulverize technique are as follows: stream pressure be 0.70-1.0MPa, gas flow temperature be 10-15 DEG C under conditions of, control air-flow The variable-frequency motor revolving speed of formula micronizer is 14500-16500r/min, the albumen powder for being 5-8 μm by crushing material to granularity Body;
Micronized technique are as follows: protein powder is made into the protein dispersion that concentration is 0.08-0.12g/mL, it is damp and hot at 85-95 DEG C After handling 25-35min, uses revolving speed to emulsify cutter for the high speed of 10000-15000r/min and handle 2-5min.
7. a kind of preparation method of double protein gastric cancer full nutrition formula food described in claim 1, it is characterised in that: with egg-pair White 100 grams of gastric cancer full nutrition formula food quality meters, by albumen, carbohydrate, vitamin A, vitamin D, vitamin E, dimension Raw element K1, vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacin, folic acid, pantothenic acid, vitamin C, biotin, sodium, Potassium, copper, magnesium, iron, zinc, manganese, calcium, phosphorus, iodine, selenium, chromium, glutamine, branched-chain amino acid, EPA, genistein derivative, nucleosides After the raw material sterilizing of sour nutritional ingredient, 5 parts are divided into, function bag is formed;
After the raw material sterilizing of lipid nutrition ingredient, 5 parts are divided into, energy bag is formed.
8. the preparation method of double protein gastric cancer full nutrition formula food according to claim 7, it is characterised in that: sterilizing function Rate is 425-500W, sterilization time 100-120s.
9. a kind of eating method of double protein gastric cancer full nutrition formula food described in claim 1, it is characterised in that:
The age of target group is 18-64 years old, does not include pregnant woman and breast feeding women;
Dosage are as follows: 0.4 bag/(kgd), total amount is no more than 27 bags;
It is edible according to one of following two method:
(1) it is cooled to 40-60 DEG C with the boiled water of 100-200mL, the nutriment in function bag and energy bag is added, stirs, shake After even, directly drink or taken in through tube feed;
(2) nutriment in function bag is added in the diet without containing salt and is eaten, contained in diet Fat is consistent with the fat content in energy bag.
10. a kind of marketing method of double protein gastric cancer full nutrition formula food described in claim 1, it is characterised in that: sale Mode is to be distributed directly to consumer not by hospital, supermarket or pharmacy.
CN201810820029.2A 2018-07-24 2018-07-24 Double protein gastric cancer full nutrition formula food and preparation method thereof Pending CN108936623A (en)

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Application publication date: 20181207