CN109349618A - Constipation tailored version clinical nutrition formula and preparation method thereof - Google Patents

Constipation tailored version clinical nutrition formula and preparation method thereof Download PDF

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Publication number
CN109349618A
CN109349618A CN201811237151.3A CN201811237151A CN109349618A CN 109349618 A CN109349618 A CN 109349618A CN 201811237151 A CN201811237151 A CN 201811237151A CN 109349618 A CN109349618 A CN 109349618A
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parts
constipation
powder
clinical nutrition
tailored version
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尤俊
季敬东
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Shanghai Olympic Medical Biotechnology Co Ltd
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Shanghai Olympic Medical Biotechnology Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The present invention provides a kind of constipation tailored version clinical nutrition formula, including following component and its parts by weight: 5-10 parts of fat, 20-35 parts of carbohydrate, 45-55 parts of dietary fibers, 0.005-0.02 parts of liposoluble vitamins, 0.008-0.2 parts of water soluble vitamins, 2-6 parts of diet essence, 0.1-8 parts of integration of drinking and medicinal herbs ingredients, 0.1-2 parts of natural plants compounds and 1-7 parts of new resource foods；The present invention also provides the preparation methods of above-mentioned clinical nutrition formula.Constipation tailored version clinical nutrition formula of the invention can alleviate because neuroendocrine disorders, gastroenteritic power deficiency, direct stimulation, enteron aisle form there is the change of non-physiologic, professional Medical Degree, nutrition auxiliary are provided for constipation patient, and constipation patient can be helped to improve body function disorder caused by nutritional deficiency.

Description

Constipation tailored version clinical nutrition formula and preparation method thereof
Technical field
The present invention relates to clinical nutrition formulation art more particularly to a kind of constipation tailored version clinical nutrition formula and its preparations Method.
Background technique
Constipation refers to that defecation frequency is reduced, while difficult defecation, excrement are dry and hard.The daily defecation of normal person 1~2 time or 1~2 Day defecation 1 time, defecation is less than 3 times constipation patient weekly, and defecation is laborious, and the scleroma of excrement matter, amount are few.
The pathogenesis of constipation is mainly the following situation:
(1) Intestinal Tract Morphology changes:
It is mainly manifested in and advocates muscle, intramural plexus and Cajal interstitial cells in intestine exception；Gastrointestinal smooth muscle conduct Its movable final effect device, afunction will lead to colonic activity change；Research confirms that the patient of function of intestinal canal exception deposits In smooth muscle structure and morphological abnormalities, including different degrees of fibrosis, muscle fiber hyperplasia or atrophy and myocyte's blown-out shot shape At；For patients with chronic constipation there is also inclusion myopathy, inclusion body is a kind of performance that smooth muscle is degenerated；Chronic constipation person's is straight There are stove vacuoles and muscle fibre to dissolve for intestines, and muscular layer of mucosa is thinning, the decline of ring longitudinal muscle ratio, and lesion presents and carries out sexual development；
Electrophysiologic study discovery: the enteron aisle of intractable constipation patient prompts non-adrenal gland energy, non-cholinergic neuronal conduction to prolong It is long, inhibit having a rebound property electrical activity after conduction；Under quiescent condition, when smooth muscle membrane depolarization, it is less to generate action potential；Intestines Intramural plexus includes meissnar's plexus and myenteric nerve plexus, and patients with chronic constipation is primarily present myenteric nerve plexus change, knot Enteral myenteric nerve plexus area reduces, and gangliocyte quantity is reduced in neuropile, and proliferation of nerve fibers, the pathology such as disorder change Become；
The method of immunohistochemistry shows that constipation person myenteric nerve plexus gangliocyte and neuronal cell significantly reduce, nerve The ratio of spongiocyte increased significantly, and show as depauperation nerve section disease, and meissnar's plexus does not change；
Cajal cell is a kind of special interstitial cell, is generator and the conduction person of Gastroenteric Electrical slow wave, will come from nerve The stimulation of humoral system is transmitted to effector smooth muscle cell, to adjust the movement of gastrointestinal tract；
Studies have shown that colon ICC quantity is reduced, cellular morphology changes, iuntercellular network structure leads to colonic peristalsis extremely Frequency deceleration may be the mechanism of constipation of slow-remove type morbidity；In recent years, Calcium overload also intracellular some researches show that ICC ICC autophagy can be caused, so as to cause the exception of cellular morphology and function, this is extremely related with gastrointestinal tract dynamia.
(2) gastrointestinal regulation peptide changes:
Vasoactive peptide (VIP) is a kind of inhibitory neurotransmitter, plays inhibition adjustment effect to gastrointestinal movement, makes to tie Bowel movement weakens, and adjusts the fluid metabolism of enteron aisle, and intestinal juice can be made to increase the water content for increasing excrement；
Nitric oxide is very strong inhibitory neurotransmitter, and main by inhibiting L-type calcium channel, activation is big conductance calcium-activated Potassium channel inhibits smooth muscle contraction；The generation of gastrointestinal tract dyskinesis may be with NO synzyme after zoopery discovery injured spinal cords The expression of albumen (iNOS) is increased related；
Cholecystokinin (CCK) is a kind of brain intestines for being widely distributed in animal digestive system, maincenter and peripheral neverous system Peptide discharges in addition to that can directly act on the gastrointestinal tract mucous acetylcholine that may also suppress, the release of VIP, NO is stimulated, to delay Gastrointestinal smooth muscle is shunk；
Acetylcholine has starting effect in gastrointestinal motility, and cholinergic neuron proportion is maximum between enteron aisle flesh, Acetylcholine causes the effect of smooth muscle contraction related to its burst size and receptor；
In addition, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, serotonin play an important role in intestinal smooth is shunk, the vertical smooth muscle harmony of ring is shunk, There is positivity to regulate and control meaning intestines peristalsis；However there may be exceptions for these neurotransmitters in patients with chronic constipation, including pass Matter burst size is insufficient, and reacting cells low to the reactivity of its excitement are reduced etc..
(3) Colon and rectum feeling, motor function and content are abnormal:
The imbalance of brain-gut axis dysfunction of nervous regulation and anal orifice and rectal intestine dissection obstruction are the important originals for leading to Treatment of Outlet Obstruction Type Constipation Cause；Intestinal mucosa transient receptor potential vanilloid receptor experiences signal in enteric cavity as the receptor on enteron aisle afferent nerve, when It, which expresses up-regulation, can lead to intestinal motive force obstacle.
(4) psychologic factors influence:
Have scholar it has been suggested that Functional Gastrointestinal Disease concept, it is indicated that gastrointestinal physiology pathological change by heredity, environment While influence, also by psychosocial influence；
While passive spiritual sensory stimuli expands transverse colon and sigmoid colon in short term, the threshold of feelings is also gradually It increases, and then cuts down stimulation of the excrement to intestinal wall；
It is presently believed that the generation of IBS irritable bowel syndrome is related to brain-gut axis dysfunction.Functional consitipation (FC) with IBS-C (constipation-predominant of irritable bowel syndrome) is the common type of constipation, morbidity and mental emotion, the close phase of cerebration It closes.
(5) nerve immunity reaction intervention:
IBS-C is one kind of constipation, shows as abdominal pain, the discomfort of recurrent exerbation, subtracting with defecation frequency when breaking-out Less or excrement is dry；It is presently believed that during irritable bowel syndrome morbidity, nerve immunity reaction has certain effect, grinds When studying carefully discovery IBS-C paresthesia epilepsy, connects and change between Colon mucosa cell, on the one hand show as total colectomy iuntercellular The quantity for being adhesively joined albumen reduces the disorder of adjoint structure；On the other hand cell tight junction albumen between gut epithelium is shown as ZO-1 fracture, enteron aisle mechanical barrier is impaired, and the key of this process is the work of enteric nervous member proteinase activated receptors (PAR) Change；The neuron of activation discharges specific gastrointestinal regulation peptide, successively activates colonic epithelium and mast cell (MC), MC releases group Amine, protease or prostaglandin etc., act on intestinal epithelial cell, lead to permeability changes；The distribution of Mucosa Biopsy prompt MC The nerve fibre reacted with immuno positive is neighbouring, MC activation after, release active material act on surrounding endocrine cell and Nerve fibre makes it discharge a large amount of braingut petides, such as Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 (SP), calcitonin gene-related peptide (CGRP)；In MC surrounding tissue Neuronspecific enolase (NES), SP, 5-HT expression quantity significantly increase, thus it is speculated that this may be with IBS visceral Related, the active particle that MC is discharged with it plays an important role in Neuroendocrine-immunoregulatory network；The study found that IBS Microbial reaction and flagellin antibody level increase in different subtype patients serum, in enteron aisle the activation of mucomembranous immune system be It destroys what gut epithelium barrier function was completed by potential pathogenic microorganism, and proposes that 5-HT will mediate exempt from the such congenital and day after tomorrow Play a significant role during interacting between epidemic disease response.
(6) other associated effects:
Investigation shows female constipation patient either functional consitipation, chronic constipation or severe constipation, and illness rate is aobvious It writes and is higher than male；
On the one hand this is related with the intracorporal distinctive progestational hormone of women, and progestational hormone can reduce the convergent force of intestinal muscle, Inhibit the frequency of intestines peristalsis, and its negative effects is positively correlated with dosage；When hormonal readiness raising or the expression of its receptor height When, the suppressed effect of colon just becomes apparent from, and constipation symptom is more prominent；
On the other hand, women is in gestation, childbirth etc. in special physiological activity, basin bottom support structure and nerve damage all with Constipation occurs in close relations.
(7) drug effect
Predominantly opioid drug, depressor, cation drug, antidepressants etc.；
The mechanism that most drugs cause constipation includes two o'clock: 1 inhibits the release of enteron aisle excitatory neurotransmitter, extends colon Transmission time inhibits intestines peristalsis；On the other hand the character and ingredient that excrement can be changed, cause difficult defecation；Constipation can also be with Secondary to other diseases, such as metabolic disease, autoimmune disease, the nervous system disease and enteron aisle itself disease etc..
Constipation receives the extensive concern of people, Chinese medicine and doctor trained in Western medicine have carried out greatly constipation as a kind of often hair symptom Quantifier elimination simultaneously achieves certain progress:
(1) the Chinese medicine progress of constipation:
The sick position of constipation in large intestine, but and liver, spleen, kidney connection is the closest, and pathogenic factor and disorder of emotion, diet are not Section, the factors such as overstrain is physically weak are related, especially most close with disorder of emotion relationship；Long-term emotional discomfort, anxiety and rage are excessive, cause Liver dysfunction, functional activity of QI being not smooth, train of thought numbness hinder then abdominal pain；Stagnation of liver qi, catharsis is not normal, and perverse and unreasonable manner multiplies spleen or weakness of the spleen and the stomach, the empty wood of soil Multiply, the dysfunction of the spleen in transport, cause enteron aisle transporting conduction function not normal and fall ill, depression and stagnation of QI, intestines, which lose to lead to, to drop, stops in waste matter, defecates interior Knot；Clinically irritable bowel syndrome constipation type is again common with stagnation of QI due to depression of the liver.
Chinese traditional treatment constipation is mainly based on oral medicinal herb, and some researches show that Liumotang treatment constipation type intestines easily swash is invited comprehensive Simulator sickness tool have a better effect (Liumotang: each 10g of radix aucklandiae, the root of three-nerved spicebush, the dried immature fruit of citron orange, agalloch eaglewood (rear under) 6g, betel nut 9g, raw rhubarb (after Under) 8g, radix bupleuri 10g, rhizoma cyperi 9g, Fructus meliae toosendan 6g, radish seed 9g, licorice 6g, 1 dose/d, decocting takes juice 400ml, morning and evening each one Partly warmly take.Continuous treatment 30d is as a treatment course, 90%) treatment total effective rate is；
In addition, there are also colon hydrotherapy, thin fragrant moxibustion, five notes of traditional Chinese music therapy, the methods of catgut implantations at acupoint for Chinese traditional treatment constipation.
The mechanism of Chinese medicine treatment constipation essentially consists in the interaction of Chinese medicine and intestinal microenvironment: the microenvironment of enteron aisle includes Intestinal flora, intestinal cell and mucous membrane chemical barrier are human body and extraneous the first screen for carrying out substance, energy and information exchange The interactive interface of human body under the extraneous factors and physio-pathological state such as barrier and diet-drug-pathogenic microorganism, intestines Road flora is the microflora in people's enteron aisle, is largely focused on Firmicutes, Bacteroidetes, and minority is distributed in mycetozoan Door, actinomyces door, wart germ door and Fusobacterium door；Major function of the intestinal flora to Human Physiology are as follows: 1, pass through itself enzyme Promote the non-digestible nutriment of intestinal absorption, 2, promote developing immune system, 3, resist pathogen invasion, 4, promote enteron aisle blood Pipe generate, 5, protect gut epithelium from damage.Chinese medicine can adjust intestinal microenvironment, and then play the role for the treatment of constipation.
(2) the doctor trained in Western medicine progress of constipation:
General treatment of the doctor trained in Western medicine for constipation are as follows: good living habit is established while treating constipation, on diet Appropriate to increase dietary fiber, high fiber food helps improvement constipation, eats the food of induced symptom less；Excessive rouge generally should be avoided The intake of fat and irritable food.Sports appropriate etc. can increase the stimulation to colon, promote gastroenteritic power；Adjust feelings Thread and behavior keep the life style of good phychology and rule.
Doctor trained in Western medicine mainly includes following several drugs for the drug therapy of constipation:
1, irritant purgative: including phenolphthalein piece, rheum officinale folium sennae, Maren wan, castor oil etc. can directly stimulate enterocinesia, Reduce moisture absorption；Available effect in short term, is but easy to appear electrolyte disturbance, the adverse reactions such as abdominal pain；Long-time service can be led It causes patient to aggravate the dependence of cathartic and constipation progressive, takes cathartic for a long time and also result in the complication such as malnutrition, it is at a specified future date Curative effect is dissatisfied；
2, promote digestive tract power reinforcing medicine: some researches show that the medicines for promoting gastroenteritic power to promote intestinal gas to be discharged, and accelerates enteron aisle fortune It is dynamic, the treatment of IBS-C patient is had a better effect, Mosapride, by agonist, there is promotion gastroenteritic power as 5-HT4, The function of stimulating acetylcholine to discharge；Research confirms that Mosapride can relax by expanding about flesh in 5-HT4 receptor enhancing cavy anus It opens and the rectum of proctectasia excitation is shunk；It can promote Colon Movement simultaneously, it therefore, may be effectively to treatment functional consitipation；
3, antipsychotic drug: research shows that the abdominal distension of IBS patient, abdomen can quickly be eliminated and be improved to the utilization of antidepressants Bitterly, constipation, anxiety and tense, irritable and depressive symptom.
Chinese patent CN104872638A discloses a kind of constipation non-whole nutritional formula food, uses a variety of through prehydrolysis Small peptide, the prebiotics, amino acid, carbon hydrate that SBE technology extracts the Chinese medical extract essence of dual-purpose of drug and food, biological enzymolysis extracts Object, the grease for having healthcare function, multivitamin and minerals the techniques such as are mixed together and are processed into, and can be used as single battalion Feeding source meets the nutritional need of constipation patient, also acts relax bowel and defecation, nourishing yin to moisten dryness, nourishing liver and kidney, heat-clearing disperse accumulation, promoting Defaecation, removing toxic substances laxation and anti-the effect for the treatment of constipation.But although the constipation non-whole nutritional formula food of the patent uses type A considerable number of component is prepared into nutritional formulas, but its main " middle residence that disappears is mended ", " balanced tone " according to Chinese medicine is managed By in all directions from immune component, neuroendocrine, spiritual nutrition, myoelectricity block not in conjunction with the pathogenesis of constipation Nutritional support and auxiliary are provided for constipation patient.
Therefore it provides a kind of can interfere the morphologic change of gastrointestinal tract in terms of immune component, divide out of nerve It secretes aspect the endocrine disturbance mechanism of gastrointestinal tract is adjusted, the body and mind of constipation patient is repaired in terms of spiritual nutrition It is multiple, will have in terms of the block of myoelectricity to the constipation tailored version clinical nutrition formula interfered that is short of power of gastrointestinal tract There is important clinical meaning.
Summary of the invention
The technical problems to be solved by the present invention are: in view of the drawbacks of the prior art, it is clinical to provide a kind of constipation tailored version Nutrient formulation and preparation method thereof can be alleviated because of neuroendocrine disorders, gastroenteritic power deficiency, direct stimulation, enteron aisle There is the change of non-physiologic in form, provides professional Medical Degree, nutrition auxiliary for constipation patient, and can help constipation patient Improve body function disorder caused by nutritional deficiency.
The present invention uses following technical scheme to solve above-mentioned technical problem:
The first purpose of the invention is to provide a kind of constipation tailored version clinical nutrition formula, including following component and its again Measure number: 5-10 parts of fat, 20-35 parts of carbohydrate, 45-55 parts of dietary fibers, 0.005-0.02 parts of liposoluble vitamins, 0.008-0.2 parts of water soluble vitamins, 2-6 parts of diet essence, 0.1-8 parts of integration of drinking and medicinal herbs ingredients, 0.1-2 parts of natural plants chemical combination Object and 1-7 parts of new resource foods；
Wherein, the integration of drinking and medicinal herbs ingredient includes cassia seed, endothelium corneum gigeriae galli, dandelion, Poria cocos, semen ziziphi spinosae, radish seed, Yu Li At least one of benevolence, peach kernel, Chinese yam, oyster, black pepper, Radix Glycyrrhizae, the sophora bud, peppermint, lily, dried orange peel, root of Dahurain angelica；
Wherein, the new resource food includes first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, the leaf of bamboo Flavones, casein phosphopeptide, avenabeta glucosan, yeast beta-dextran, newborn mineral salt, pueraria root powder, Rosa roxburghii Tratt, xylo-oligosaccharide, circle At least one of luxuriant isapgol husk, Noni puree, lactobacillus.
In order to optimize above-mentioned technical solution, the technical measures that the present invention takes further include:
Further, the fat includes saturated fatty acid, polyunsaturated fatty acid, monounsaturated fatty acids, OPO structure At least one of rouge, DHA, EPA, ARA, phosphatide.
Further, the fat includes olive oil；Further, the parts by weight of the olive oil are 5-6 parts.
Further, the carbohydrate includes fructose, rock sugar, lactose, maltodextrin, tapioca, resistant starch At least one of.
Further, the carbohydrate includes maltodextrin；Further, the parts by weight of the maltodextrin It is 20-30 parts；More preferably 22-25 parts.
Further, the dietary fiber includes inulin, konjaku flour, galactooligosaccharide, oligofructose, oligomeric different malt At least one of sugar, soybean polyoses, cyclodextrin, resistant dextrin, soybean fiber.
Further, the dietary fiber includes inulin and galactooligosaccharide；Further, the dietary fiber includes 5-10 parts of inulin and 5-10 parts of galactooligosaccharides.
Further, the dietary fiber is resistant dextrin, inulin and galactooligosaccharide；Further, the diet The parts by weight of each component in fiber are as follows: 25-45 parts of resistant dextrin, 5-10 parts of inulin, 5-10 parts of galactooligosaccharide；More preferably For the parts by weight of each component in the dietary fiber are as follows: 40-45 parts of resistant dextrin, 5-8 parts of inulin, galactooligosaccharide 5-8 Part.
Further, the liposoluble vitamin includes vitamin A, beta carotene, vitamin D3, vitamin E, dimension life Plain K1At least one of.
It further, include 0.005-0.01 parts of vitamin Es in the liposoluble vitamin.
Further, the water soluble vitamin includes vitamin B1, vitamin B2, vitamin B6, vitamin B12, dimension life At least one of plain C, pantothenic acid, folic acid, niacin, choline, inositol, biotin.
Further, the water soluble vitamin includes vitamin B1, vitamin B2, vitamin B6, vitamin B12, dimension life Plain C.
Further, each component and its parts by weight in the water soluble vitamin are as follows: vitamin B10.001-0.005 Part, vitamin B20.001-0.005 parts, vitamin B60.001-0.005 parts, vitamin B120.0000001-0.000002 parts, 0.1-0.5 parts of vitamin C.
Further, the diet essence includes cereal, beans, potato, greengrocery, Homonemeae, nut-seed class, fishes and shrimps At least one of class, poultry meat, fruits；Wherein, the cereal include rice meal, millet flour, black rice flour, coixlacrymajobi powder, At least one of corn flour, wheat germ powder, oatmeal, buckwheat；The beans include peameal, mung bean flour, black bean powder, At least one of red bean powder, soy meal；The potato is mainly made of common yam rhizome powder, and the greengrocery includes carrot meal, white trailing plants At least one of Bu Fen, pumpkin powder, spinach powder, tomato meal, broccoli powder, balsam pear powder；The Homonemeae includes mushroom powder, sea Band at least one of powder, tremella powder；The nut-seed class includes at least one of pumpkin seed powder and lotus nut starch；The fish Shrimps include at least one of salmon powder and cod meal；The poultry meat chicken meal, powdered beef, in pig kidney powder at least It is a kind of；The fruits include red date powder, longan powder, apple powder, cherry powder, citrus powder, pyrus nivalis powder, in Opuntia ficus' powder It is at least one.
Further, the diet essence includes at least oatmeal and white radish powder；Further, the oatmeal Parts by weight are 1-3 parts, and the parts by weight of the white radish powder are 1-3 parts.
Further, the integration of drinking and medicinal herbs ingredient includes cassia seed, endothelium corneum gigeriae galli, radish seed, dandelion, brush-cherry seed, peach kernel.
Further, the integration of drinking and medicinal herbs ingredient further includes the sophora bud, peppermint, semen ziziphi spinosae, lily, dried orange peel, the root of Dahurain angelica.
Further, cassia seed in the integration of drinking and medicinal herbs ingredient, endothelium corneum gigeriae galli, radish seed, dandelion, brush-cherry seed, peach kernel Parts by weight are as follows: 0.1-1 parts of cassia seed, 0.1-1 parts of endothelium corneum gigeriae galli, 0.1-1 parts of radish seed, 0.1-1 parts of dandelion, brush-cherry seed 0.1- 1 part, 0.1-1 parts of peach kernel.
Further, in the integration of drinking and medicinal herbs ingredient sophora bud, peppermint, semen ziziphi spinosae, lily, dried orange peel, the root of Dahurain angelica parts by weight Are as follows: 0.1-1 parts of the sophora bud, 0.1-1 parts of peppermint, 0.1-1 parts of semen ziziphi spinosae, 0.1-1 parts of lily, 0.1-1 parts of dried orange peel, 0.1-1 parts of the root of Dahurain angelica.
Further, the natural plants compound includes L-carnitine, Glucosamine, oligofructose, lutein, plant At least one of object sterol, lycopene, resveratrol, allicin.
Further, the natural plants compound includes L-carnitine；Further, the weight of the L-carnitine Number is 0.1-1 parts.
Further, the lactobacillus in the new resource food includes lactobacillus acidophilus, lactobacillus plantarum, rhamnose cream bar At least one of bacterium.
Further, the new resource food includes chitosan oligosaccharide, circle luxuriant isapgol husk, Noni puree, lactobacillus acidophilus, plant Object lactobacillus, Lactobacillus rhamnosus, avenabeta glucosan.
Further, chitosan oligosaccharide, circle luxuriant isapgol husk, Noni puree, lactobacillus acidophilus, plant in the new resource food Object lactobacillus, Lactobacillus rhamnosus, avenabeta glucosan parts by weight are as follows: the luxuriant isapgol husk 3-5 of chitosan oligosaccharide 0.1-0.5, circle Part, 0.1-1 parts of Noni puree, 0.01-0.03 parts of lactobacillus acidophilus, 0.01-0.02 parts of lactobacillus plantarum, Lactobacillus rhamnosus 0.01-0.02 parts, 0.1-1 parts of avenabeta glucosan.
A second object of the present invention is to provide a kind of preparation methods of above-mentioned constipation tailored version clinical nutrition formula, including Following steps:
Step 1, fat powder is prepared；
Step 2, integration of drinking and medicinal herbs ingredient and vitamin are prepared into powder particle diameter is 60~80 mesh powders；
Step 3, by the carbohydrate of predetermined weight, dietary fiber, diet essence, natural plants compound and new money Source food is prepared into the powder that powder particle diameter is 150~250 μm respectively；
Step 4, powder obtained by step 1~3 is sequentially added into mixing machine and is uniformly mixed obtained formula mixture, passed through It is spare after sterilization processing；
Step 5, the formula mixture is prepared into nutrient powder, nutrition emulsion, capsule, tablet, pill or oral solution At least one of；
Wherein, the sequence of step 1~3 can be replaced mutually.
In order to optimize above-mentioned preparation method, the technical measures that the present invention takes further include:
Further, in step 1 fat powder preparation method the following steps are included:
1) it prepares wall material aqueous solution: maltodextrin 8g, Arabic gum 0.2g, water 20mL being taken to stir evenly；
2) 0.1g (total solid concentration is 0.2%) is taken uniformly to be dissolved in the olive oil of 6.7mL monoglyceride；
3) 0.1g (total solid concentration is 0.2%) is taken uniformly to be dissolved in the wall material aqueous solution Tween 80；
4) the wall material aqueous solution of the mixed plant grease and addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added It is sufficiently mixed, obtains mixed solution；
5) stabilizer agar 0.1g (total solid concentration is 0.2%) is added after the mixed solution, is settled to water High speed dispersion 2 minutes under 200mL (total solid concentration is 25%), 20000r/min, emulsion is obtained；
6) by the emulsion at homogenization pressure 25MPa, homogeneous 3 times, 5 minutes every time, homogeneous emulsion is obtained；
7) the homogeneous emulsion is spray-dried, inlet air temperature is 195 DEG C, and leaving air temp is 80 DEG C, is collected To fat powder.
Further, in the step 2 preparation method of integration of drinking and medicinal herbs component powders the following steps are included: using pulverizer The raw material of predetermined weight number is crushed, the raw material of crushing is placed in container, 3~8 that weight is raw material weight are added Water again, carries out immersion 3~4 hours, then carries out 30~60min of decoction to soak, and filtering removal raw material leaves and takes decoction Liquid is spray-dried decoction liquor, prepares integration of drinking and medicinal herbs component powders with 60~80 meshes point.
Further, in the step 2 preparation method of vitamin powder the following steps are included: by predetermined weight number Liposoluble vitamin selects carragheen, Arabic gum as wall material as core material, carries out 2 emulsifying homogeneous processing under high pressure, The emulsifying homogeneous time is 10~15min, is then instantaneously dried by spraying, prepares liposoluble vitamin powder with 60~80 meshes point End；Using the water soluble vitamin of predetermined weight number as core material, selects maltodextrin, lipoprotein as wall material, is uniformly mixed, It is spraying instantaneous dry, water soluble vitamin powder is prepared with 60~80 meshes point.
Further, optionally increase suitable food thickening agent and food additives in the step 5.
Further, the food thickening agent includes guar gum, xanthan gum, locust bean gum, konjac glucomannan, pectin, carragheen, fine jade At least one of rouge, gelatin, Arabic gum, the food additives include Aspartame, edible essence fragrance, in brown sugar It is at least one.
Further, the food thickening agent be guar gum, carragheen, Arabic gum, the food additives be Ah This Ba Tian, edible essence fragrance.
In the present invention using including cassia seed, endothelium corneum gigeriae galli, radish seed, dandelion, brush-cherry seed, peach kernel integration of drinking and medicinal herbs at Point, there is toxin-expelling intestine-moistening after mentioned component compatibility synergy, promote intestines peristalsis, enhancing gastro-intestinal digestion ability, enhancing immune function Effect, facilitate restore gastrointestinal tract form, adjust gastrointestinal tract endocrine disturbance.
The rheum emodin that cassia seed contains can help heat-clearing, ease constipation, the side that the junk of human body is effectively passed through defecation Formula excretes, cassia seed nourishing Yin and clearing heat, and, toxin accumulation unsmooth for defecation caused by interior heat also has good remission effect；
Endothelium corneum gigeriae galli sugariness is puckery, puts down, nontoxic, enters spleen, stomach, small intestine, wing moon bright four and passes through, be good at digestion gathered food, strengthening the spleen and stomach, it is puckery it is glutinous only Lose, change hard product and disappear calculus, can be used for dyspepsia, vomiting dysentery, infantile malnutrition, the enuresis, spermatorrhea, the puckery pain of urolithiasis, distension of gallbladder, hypochondriac pain, Canker sore is quenched one's thirst, the proliferation of mammary gland, amenorrhoea, the diseases such as fibroid；Modern research shows that endothelium corneum gigeriae galli is mainly by albumen texture At main component has gastric hormone, keratin like protein, pepsin, and contains the amino such as vitamin, glutamic acid and asparatate Acid has the ability for increasing gastric secretion, gastro-intestinal digestion, can accelerate the rate of evacuation of stomach, is improving blood lipid, hemorheology There is potential bioactivity with myocardial preservation aspect；
Radish seed is containing raphanin, sinapine, fat oil, cupreol, carbohydrate and a variety of amino acid, vitamin etc., grease The effect for itself having yin-nourishing QI invigorating, relax bowel and defecation, has better effect to habitual constipation person；Animal experiments show that radish seed water Decoction can be such that isolated rabbit intestines shrinkage amplitude increases, and Guinea pig Gastric shrinkage amplitude can be made to increase；Chinese medicine thinks that radish seed has lower gas, dispels The function of phlegm, promoting digestion and removing indigestion；
Dandelion property bitter sweet is trembled with fear, and liver, stomach meridian are entered, and has the benefits of clearing heat and detoxicating, diuresis dissipating bind；" dandelion exempts from mouse Hypoimmunity mice can be improved in discovery, dandelion in the adjustment effect of epidemic disease function " (Yu Xinhui is published in Chinese Medicine guide) Immune function has the function of enhancing the formation of the phagocytosis system, hemolysis plaque of the macrophage of body；
Brush-cherry seed plays the role of significantly promoting enterocinesia, and the influence to constipation is the most significant with constipation type anti-constipation effect； Brush-cherry seed glucoside contained by brush-cherry seed has strong discharge function to experiment, and discharge function mechanism is similar to Sennosides, category large intestine Purgatives, but also have proof, brush-cherry seed water extract and its fat oil have extremely significant promotion intestinal motility effect to intragastric administration on mice, 50% water decoction of brush-cherry seed seed can be obviously shortened constipation type, and just close model mice defecation time, defecation frequency obviously increase；
Peach kernel has the function of relax bowel and defecation, is particularly suitable for old physically weak constipation patient, and Chinese medicine thinks that peach kernel has broken Blood become silted up, moisturizing dryness and lubricating intestine, can ease pain, anti-inflammatory, removing toxic substances, defaecation the effect of.
Using including chitosan oligosaccharide, circle luxuriant isapgol husk, Noni puree, lactobacillus acidophilus, lactobacillus plantarum, mouse in the present invention The new resource food of Lee's sugar lactobacillus, avenabeta glucosan has after mentioned component compatibility synergy and adjusts intestinal flora, promotes intestines Road wriggling, relax bowel and defecation, the function of alleviating headache, strengthen immunity help to improve stomach and intestine in terms of the block of myoelectricity Road is short of power, and helps to repair damaged cell tissue, improves gastrointestinal tract form, helps to alleviate direct stimulation to enteron aisle The influence of function.
Chitosan oligosaccharide is the dietary fiber of animality, has and promotes profitable strain (such as Bacillus acidi lactici), inhibits pernicious bacteria The effect of breeding；Chitosan oligosaccharide can promote the wriggling of enteron aisle as cationic animal origin, remove the stool and toxin of big enteral, from And adjust gastrointestinal function effectively；
The main component of circle bud isapgol husk is a kind of soluble polysaccharide, is araboxylan, it can absorb rapidly water, G., jelly-like thick liquid is formed, when we take circle bud isapgol husk aqueous solution, gel group can be formed in enteron aisle, it can be tieed up The moisture and pliability of excrement are held, improves the lubricating condition of excrement and intestinal wall, stimulation intestinal wall generates reflex contraction effect, and promotees Into the emptying for even accelerating excrement；Therefore, the luxuriant isapgol husk of circle just is used to moisten as natural laxative since ancient times Intestines defaecation；
Noni puree is rich in vitamin C, can help to repair damaged cell tissue, be natural analgesic, help to alleviate Obstinate headache and not any side effect can stimulate digestion as agent help of coming down in torrents, treat constipation and gastric acid refluence Equal enterogastric diseases, and Noni puree antioxidant also rich in；
Lactobacillus acidophilus can effectively inhibit harmful bacteria growth, gastrointestinal tract, nutrition gastrointestinal tract is protected to repair the screen of gastrointestinal tract Barrier and the flora for adjusting gastrointestinal tract；
Lactobacillus plantarum has immunoloregulation function, helps to reduce cholesterolemia and prevents cardiovascular disease, maintains stomach and intestine Colony balance, promotion absorption of nutrient ingredients, alleviation lactose intolerance, the formation for inhibiting tumour cell etc. in road；
Lactobacillus rhamnosus, which has, balances and improves gastrointestinal function, and strengthen immunity promotes Bifidobacterium and acidophilus cream Bacillus growth, prevention and treatment diarrhea, allergy, the function of toxin expelling；
Avenabeta glucosan cannot hydrolyze in small intestine, and degradation and the substrate as bacterial fermentation in large intestine, fermentation Short chain fatty acids, especially butyric acid are generated, function of intestinal canal is beneficial to, mono- glucan of oat p can make double in mouse intestinal and excrement Discrimination bacillus and Bacillus acidi lactici increment, and reduce the quantity of Escherichia coli, therefore oat beta-glucan also has improvement function of intestinal canal, Promote the increment of intestinal beneficial bacterium；For beta glucan as a kind of nonspecific immunomodulator, it can not only activate T, B lymph The immunocytes such as cell, macrophage, natural killer cells, moreover it is possible to promote cell factor to generate, activating complement system promotes anti- Body generates, and plays various adjustment effects to immune system.
The present invention by adopting the above technical scheme, compared with prior art, has the following technical effect that
1) galactooligosaccharide is added, galactooligosaccharide is strongest double qi proliferation factors, and effect includes blocking pathogen In the adherency and promotion intellectual development etc. of intestinal mucosa renal function.
2) inulin is added, inulin helps to control blood glucose, reduces blood lipid, promotes mineral absorption, adjusts enteric microorganism Flora improves intestinal health, and the generation for preventing constipation, inhibiting toxic tunning protects liver, prevents colon cancer, anti-constipation And treatment obesity diet fiber reduces food in the residence time of stomach and intestine, and increases excrement amount, effectively treats constipation；Its Antiobesity action is the viscosity for improving content, reduces food and enters the speed of small intestine from stomach, to reduce hunger, reduces food Food ration；There is a small amount of 2-9 oligofructose in inulin, studies have shown that oligofructose can make brain nervous cell trophic factors Expression increases, and has good protective effect to the neuron harm of cortisone induction, has good antidepressant effect.
3) 0.005-0.01 parts of vitamin Es are added, vitamin E has the effect of convergence, softening hard masses, and anal canal can be made to be in longer Time relaxed state lowers the pressure in anal canal, sphincterismus is enable to alleviate, and promotes anus blood circulation, improves Nutrition and Metabolism in anus.
4) it also added on the basis of above-mentioned integration of drinking and medicinal herbs is at subassembly including the sophora bud, peppermint, semen ziziphi spinosae, lily, old The integration of drinking and medicinal herbs ingredient of skin, the root of Dahurain angelica: sophora bud bitter cold nature returns liver, large intestine channel, and the sophora bud cold in nature can increase the lubrication of enteron aisle Degree, plays the role of defaecation, and the sophora bud enters large intestine channel, can act on large intestine, plays the role of promoting intestinal health, the and " sophora bud Mongolian oak in protective effect research of the middle Quercetin to anxiety model mice " (Nie Zhongfu is published in " China Dispensary ") discovery sophora bud Pi Suneng has angst resistance effect to mouse as anxiolytic diazepam, and Antianxiety Activity may be with increase intracerebral GANA, Glu content are related；The peppermint oil contained in peppermint has volatility, in vivo have promoting the circulation of qi effect, can soothing liver-qi stagnation, It can be used for treating the diseases such as stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium；Semen ziziphi spinosae has the effect of antitoxic heart-soothing and sedative, calming the liver qi-regulating, particularly suitable nerve Weak, horrified to much dream crowd eats, and also has effects that nourishing blood and tranquilization, is relatively specific for palpitaition caused by the insufficiency of heart and spleen, gas It is short, insomnia and dreamful sleep, the diseases such as dysphoria and insomnia；It is lily cold nature, sweet in flavor, there are moistening lung, cough-relieving, heat-clearing, removing toxic substances, reason spleen stomach invigorating, dampness removing Disperse accumulation, antitoxic heart-soothing and sedative promote blood circulation and other effects；Orange peel enters spleen, stomach meridian, is good at promoting the circulation of qi, can treat the disease of the taste stagnation of the circulation of vital energy, such as Abdominal fullness and distention or abdominal pain, deficiency of food receive the malaise symptoms such as poor, indigestion, chest diaphragm feeling of fullness；Root of Dahurain angelica acrid flavour, it is warm-natured, return lung, spleen, stomach, Large intestine channel has the benefits of expelling pathogenic wind from the body surface, eliminating cold to stop pain, dehumidifying sensible, detumescence and apocenosis, and modern pharmacological research proves, the root of Dahurain angelica in addition to Has the effects that antipyretic, analgesia, anti-inflammatory, moreover it is possible to improve local blood circulation, eliminate pigment excess accumulation in the tissue, promote skin Skin cell metabolism, and then have the function that beauty, clinic is common control anemofrigid cold, headache, toothache, pain in the supra-orbital bone, nasosinusitis, Intestines wind anal fistula, leukorrhea with reddish discharge, ulcer sores, venomous snake bite etc.；After mentioned component compatibility synergy, peomote intestinal health, Enhance gastro-intestinal digestion ability, also there is the benefits of antianxiety, antitoxic heart-soothing and sedative, facilitate gastrointestinal tract caused by reducing spiritual sensory stimuli Dysfunction repairs the body and mind of constipation patient in terms of spiritual nutrition, facilitates in terms of neuroendocrine to stomach and intestine The endocrine disturbance mechanism in road is adjusted.
The present invention by select rational proportion basal nutrient element, while add have toxin-expelling intestine-moistening, promote intestines peristalsis, Enhance gastro-intestinal digestion ability, alleviate gastrointestinal dysfunction, antitoxic heart-soothing and sedative, enhance the dietary fiber of immune function, diet essence, The special dietaries substances such as integration of drinking and medicinal herbs ingredient, natural plants compound and new resource food, and adjust its proportion and sought with basis It supports element and carries out compatibility synergy, the constipation tailored version clinical nutrition formula of the invention made is easier to be absorbed by constipation patient, thus The effect of giving full play to each component provides professional Medical Degree, nutrition auxiliary for constipation patient, and constipation patient is helped to improve battalion Support body function disorder caused by lacking.
Specific embodiment
The present invention provides a kind of constipation tailored version clinical nutrition formulas comprising following component and its parts by weight: 5- 10 parts of fat, 20-35 parts of carbohydrate, 45-55 parts of dietary fibers, 0.005-0.02 parts of liposoluble vitamins, 0.008-0.2 Part water soluble vitamin, 2-6 parts of diet essence, 0.1-8 parts of integration of drinking and medicinal herbs ingredients, 0.1-2 parts of natural plants compounds and 1-7 Part new resource food；Wherein, the integration of drinking and medicinal herbs ingredient includes cassia seed, endothelium corneum gigeriae galli, dandelion, Poria cocos, semen ziziphi spinosae, radish At least one of son, brush-cherry seed, peach kernel, Chinese yam, oyster, black pepper, Radix Glycyrrhizae, the sophora bud, peppermint, lily, dried orange peel, root of Dahurain angelica； Wherein, the new resource food includes first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, bamboo-leaves flavones, junket egg White phosphoeptide, avenabeta glucosan, yeast beta-dextran, newborn mineral salt, pueraria root powder, Rosa roxburghii Tratt, xylo-oligosaccharide, the luxuriant semen plantaginis of circle At least one of shell, Noni puree, lactobacillus.
The present invention is described in more detail below by specific embodiment, for a better understanding of the present invention, But following embodiments are not intended to limit the scope of the invention.
Embodiment 1
Constipation tailored version clinical nutrition formula of the present invention includes olive oil 6g, maltodextrin 25g, resistant dextrin 40g, inulin 5g, galactooligosaccharide 5g, vitamin E 0.009g, vitamin B10.001g, vitamin B20.001g, vitamin B60.001g, vitamin B120.0000017g, vitamin C 0.16g, oatmeal 3g, white radish powder 3g, cassia seed 1g, endothelium corneum gigeriae galli The luxuriant Cillium 3g of 1g, radish seed 1g, dandelion 1g, brush-cherry seed 1g, peach kernel 1g, L-carnitine 0.8g, circle, Noni fruit starch 1g, avenabeta glucosan 1g, chitosan oligosaccharide 0.5g, lactobacillus acidophilus 0.022g, Lactobacillus rhamnosus 0.020g, lactobacillus plantarum 0.016g。
Embodiment 2
Constipation tailored version clinical nutrition formula of the present invention includes olive oil 6g, maltodextrin 34.4g, resistant dextrin 40g, inulin 5g, galactooligosaccharide 5g, vitamin E 0.009g, vitamin B10.001g, vitamin B20.001g, vitamin B60.001g, vitamin B120.0000017g, vitamin C 0.16g, oatmeal 1g, white radish powder 1g, cassia seed 0.1g, in chicken The luxuriant Cillium of golden 0.1g, radish seed 0.1g, dandelion 0.1g, brush-cherry seed 0.1g, peach kernel 0.1g, L-carnitine 0.8g, circle 3g, Noni fruit starch 1g, avenabeta glucosan 1g, chitosan oligosaccharide 0.5g lactobacillus acidophilus 0.022g, Lactobacillus rhamnosus 0.020g, Lactobacillus plantarum 0.016g.
Embodiment 3
Constipation tailored version clinical nutrition formula of the present invention includes olive oil 6g, maltodextrin 34.4g, resistant dextrin 42.3g, inulin 5g, galactooligosaccharide 5g, vitamin E 0.009g, vitamin B10.001g, vitamin B20.001g, vitamin B60.001g, vitamin B120.0000017g, vitamin C 0.16g, oatmeal 1g, white radish powder 1g, cassia seed 0.1g, in chicken The luxuriant Cillium of golden 0.1g, radish seed 0.1g, dandelion 0.1g, brush-cherry seed 0.1g, peach kernel 0.1g, L-carnitine 0.8g, circle 3g, Noni fruit starch 0.1g, avenabeta glucosan 0.1g, chitosan oligosaccharide 0.1g, lactobacillus acidophilus 0.01g, Lactobacillus rhamnosus 0.01g, lactobacillus plantarum 0.01g.
Embodiment 4
Constipation tailored version clinical nutrition formula of the present invention includes olive oil 6g, maltodextrin 25g, resistant dextrin 40g, inulin 5g, galactooligosaccharide 5g, vitamin E 0.009g, vitamin B10.001g, vitamin B20.001g, vitamin B60.001g, vitamin B120.0000017g, vitamin C 0.16g, oatmeal 3g, white radish powder 3g, cassia seed 1g, endothelium corneum gigeriae galli It is 1g, radish seed 1g, dandelion 1g, brush-cherry seed 1g, peach kernel 1g, sophora bud 1g, peppermint 1g, semen ziziphi spinosae 1g, lily 1g, dried orange peel 1g, white It is the luxuriant Cillium 3g of root of Dahurian angelica 1g, L-carnitine 0.8g, circle, Noni fruit starch 1g, avenabeta glucosan 1g, chitosan oligosaccharide 0.5g, thermophilic Lactobacillus lactis 0.022g, Lactobacillus rhamnosus 0.020g, lactobacillus plantarum 0.016g.
Embodiment 5
Constipation tailored version clinical nutrition formula of the present invention includes olive oil 6g, maltodextrin 25g, resistant dextrin 40g, inulin 5g, galactooligosaccharide 5g, vitamin E 0.009g, vitamin B10.001g, vitamin B20.001g, vitamin B60.001g, vitamin B120.0000017g, vitamin C 0.16g, oatmeal 3g, white radish powder 3g, cassia seed 1g, endothelium corneum gigeriae galli The luxuriant Cillium 3g of 1g, Poria cocos 1g, dandelion 1g, Chinese yam 1g, Radix Glycyrrhizae 1g, L-carnitine 0.8g, circle, Noni fruit starch 1g, γ-aminobutyric acid 1g, chitosan oligosaccharide 0.5g, lactobacillus acidophilus 0.022g, Lactobacillus rhamnosus 0.020g.
Embodiment 6
A kind of constipation tailored version clinical nutrition formula as described in 1~embodiment of embodiment 5 the preparation method is as follows:
1) fat powder is prepared；
A) prepare wall material aqueous solution: taking maltodextrin 8g, Arabic gum 0.2g, water 20mL to stir evenly, (side of having ready conditions adds Hot side is stirred to 60 DEG C, is cooled to room temperature after being kept for 30 minutes)；
B) 0.1g (total solid concentration is 0.2%) is taken uniformly to be dissolved in the olive oil of 6.7mL monoglyceride；
C) 0.1g (total solid concentration is 0.2%) is taken uniformly to be dissolved in the wall material aqueous solution Tween 80；
D) the wall material aqueous solution of the mixed plant grease and addition Over emulsfication agent Tween 80 of Over emulsfication agent monoglyceride will be added It is sufficiently mixed, obtains mixed solution；
E) stabilizer agar 0.1g (total solid concentration is 0.2%) is added after the mixed solution, is settled to water High speed dispersion 2 minutes under 200mL (total solid concentration is 25%), 20000r/min, emulsion is obtained；
F) by the emulsion at homogenization pressure 25MPa, homogeneous 3 times, 5 minutes every time, homogeneous emulsion is obtained；
G) the homogeneous emulsion is spray-dried, inlet air temperature is 195 DEG C, and leaving air temp is 80 DEG C, is collected To fat powder；
2) integration of drinking and medicinal herbs component powders are prepared: being crushed, will be crushed using raw material of the pulverizer to predetermined weight number Raw material be placed in container, be added weight be raw material weight 3~8 times of water, immersion is carried out 3~4 hours, then to soak 30~60min of decoction is carried out, filtering removal raw material is left and taken decoction liquor, is spray-dried to decoction liquor, with 60~80 meshes point Prepare integration of drinking and medicinal herbs component powders；
3) prepare vitamin powder: using the liposoluble vitamin of predetermined weight number as core material, select carragheen, I Primary glue carries out 2 emulsifying homogeneous processing as wall material under high pressure, and the emulsifying homogeneous time is 10~15min, is then sprayed It is instantaneous dry, liposoluble vitamin powder is prepared with 60~80 meshes point；Using the water soluble vitamin of predetermined weight number as Core material is selected maltodextrin, lipoprotein as wall material, is uniformly mixed, spraying instantaneous dry, is prepared with 60~80 meshes point water-soluble Property vitamin powder；
4) carbohydrate of predetermined weight, dietary fiber, diet essence, natural plants compound and new resources are eaten Product are prepared into the powder that powder particle diameter is 150~250 μm respectively；
5) mixing machine that powder obtained by step 1~4 sequentially adds cone-type mixer or other forms is uniformly mixed Formula mixture is made, it is spare after sterilization processing；
6) formula mixture made from step 5) is prepared by nutrient powder, nutrition emulsion, capsule according to conventional technical means At least one of agent, tablet, pill or oral solution.
In step 6), optionally increase suitable food thickening agent and food additives.The food thickening agent It is described at least one of guar gum, xanthan gum, locust bean gum, konjac glucomannan, pectin, carragheen, agar, gelatin, Arabic gum Food additives are at least one of Aspartame, edible essence fragrance, brown sugar；More preferable carragheen, Arabic gum, Guar Glue, Aspartame, edible essence fragrance.
Aforesaid operations step is both needed to carry out under the protection of inert gas, such as nitrogen, argon gas, helium etc., to prevent from producing The danger of green powder explosion.
It can be prepared into the classifications such as powdery, graininess, capsule shape, tablet shape, beverage according to the formula.
Embodiment 7
The present embodiment is verifying embodiment.
This verifying embodiment controls mice with constipation by verifying constipation tailored version clinical nutrition formula of the present invention Treatment is acted on to verify its influence to constipation patient.The present embodiment using embodiment 1-5 formula preparation nutrient powder and under State comparative example:
Control group: the suspension containing 2% india ink that distilled water is made into；
Experimental group 1: the nutrient powder prepared using the nutrient formulation of embodiment 1, and dilute dissolution and be made into containing 2% india ink Suspension；
Experimental group 2: the nutrient powder prepared using the nutrient formulation of embodiment 2, and dilute dissolution and be made into containing 2% india ink Suspension；
Experimental group 3: the nutrient powder prepared using the nutrient formulation of embodiment 3, and dilute dissolution and be made into containing 2% india ink Suspension；
Experimental group 4: the nutrient powder prepared using the nutrient formulation of embodiment 4, and dilute dissolution and be made into containing 2% india ink Suspension；
Experimental group 5: the nutrient powder prepared using the nutrient formulation of embodiment 5, and dilute dissolution and be made into containing 2% india ink Suspension；
Experimental group 6: it using the nutrient powder prepared after deletion new resource food in the nutrient formulation of embodiment 1, and dilutes molten Solution is made into the suspension containing 2% india ink.
Mice with constipation model is prepared using Kunming mouse, takes Kunming mouse totally 70, weight 25-30g, adaptability is raised It supports after a week, disposable stomach-filling compound diphenoxylate 40mg/kg, mouse may occur in which that defecation grain number is reduced, and defecation time extends Phenomena such as, establish mice with constipation model.
Above-mentioned mice with constipation model is divided into 7 groups at random, and every group 10, respectively as control group, experimental group 1, experimental group 2, experimental group 3, experimental group 4, experimental group 5, experimental group 6, the corresponding distilled water of every group of difference stomach-filling each group or nutritional agents fill daily Weishang noon, afternoon are each primary, and by 5mL/100g, (nutrient powder amount corresponding to experimental group 1- experimental group 6 is every milli to each stomach-filling amount Rise in nutritional agents and dissolve 0.1g-0.11g), continuous gavage 7d.Give each group mouse free diet during test.
Observe and record total grain number that discharge melena in the time and 4h of melena is discharged in every mouse for the first time；
Blank group in 7d, control group, experimental group 1, experimental group 2, experimental group 3, experimental group 4, experimental group 5, reality are collected respectively The defecation of the mouse of group 6 is tested, excrement calculates dejecta moisture after 90 DEG C of dry 10h；
The results are shown in Table 1 for it:
Influence of the constipation tailored version clinical nutrition formula of the present invention of table 1 to mice with constipation defecation
It can see by the result of Tables 1 and 2, experimental group 1-6 can be obviously promoted mice with constipation row compared to control group Just, dejecta moisture is improved.It is obvious positive to illustrate that constipation tailored version clinical nutrition formula of the invention has mice with constipation It influences.
as can be seen from the above embodiment ,the components of the constipation-specific clinical nutrition formula of the present invention cooperate with each other ,so that Secret patient provides nutritional support rationally, comprehensively, balanced, to improve the physical condition of constipation patient, keep patient body quality Stabilization, booster immunization responsibility, while add dietary fiber, diet essence, integration of drinking and medicinal herbs ingredient, natural plants chemical combination The special dietaries such as object and new resource food substance with have toxin-expelling intestine-moistening, promote intestines peristalsis, enhancing gastro-intestinal digestion ability, Alleviate gastrointestinal dysfunction, antitoxic heart-soothing and sedative, enhancing immune function, helps to change the form of gastrointestinal tract in terms of immune component Change is interfered, and the endocrine disturbance mechanism of gastrointestinal tract is adjusted in terms of neuroendocrine, right in terms of spiritual nutrition The body and mind of constipation patient is repaired, and is interfered in terms of the block of myoelectricity being short of power for gastrointestinal tract, Neng Gouhuan Solution is because of the change of non-physiologic occurs in the form of neuroendocrine disorders, gastroenteritic power deficiency, direct stimulation, enteron aisle, for just Secret patient provides professional Medical Degree, nutrition auxiliary, and constipation patient can be helped to improve body function caused by nutritional deficiency Disorder.
Specific embodiments of the present invention are described in detail above, but it is only used as example, the present invention is not intended to limit In particular embodiments described above.To those skilled in the art, it any equivalent modifications to the practical progress and replaces In generation, is also all among scope of the invention.Therefore, without departing from the spirit and scope of the invention made by equal transformation and repair Change, all should be contained within the scope of the invention.

Claims (10)

1. a kind of constipation tailored version clinical nutrition formula, which is characterized in that including following component and its parts by weight: 5-10 parts of rouge Fat, 20-35 part carbohydrate, 45-55 parts of dietary fibers, 0.005-0.02 parts of liposoluble vitamins, 0.008-0.2 parts it is water-soluble Property vitamin, 2-6 parts of diet essence, 0.1-8 parts of integration of drinking and medicinal herbs ingredients, the new money of 0.1-2 parts of natural plants compounds and 1-7 parts Source food；
Wherein, the integration of drinking and medicinal herbs ingredient include cassia seed, endothelium corneum gigeriae galli, dandelion, Poria cocos, semen ziziphi spinosae, radish seed, brush-cherry seed, At least one of peach kernel, Chinese yam, oyster, black pepper, Radix Glycyrrhizae, the sophora bud, peppermint, lily, dried orange peel, root of Dahurain angelica；
Wherein, the new resource food include first milk basic protein, γ-aminobutyric acid, chitosan oligosaccharide, eucommia Bark male flower, bamboo-leaves flavones, Casein phosphopeptide, avenabeta glucosan, yeast beta-dextran, newborn mineral salt, pueraria root powder, Rosa roxburghii Tratt, xylo-oligosaccharide, the luxuriant Chinese herbaceous peony of circle At least one of sub- shell, Noni puree, lactobacillus.
2. constipation tailored version clinical nutrition formula according to claim 1, which is characterized in that the dietary fiber includes chrysanthemum Powder and galactooligosaccharide.
3. constipation tailored version clinical nutrition formula according to claim 1, which is characterized in that in the liposoluble vitamin Including 0.005-0.01 parts of vitamin Es.
4. constipation tailored version clinical nutrition formula according to claim 1, which is characterized in that the integration of drinking and medicinal herbs is at subpackage Include cassia seed, endothelium corneum gigeriae galli, radish seed, dandelion, brush-cherry seed, peach kernel.
5. constipation tailored version clinical nutrition formula according to claim 4, which is characterized in that the integration of drinking and medicinal herbs ingredient is also Including the sophora bud, peppermint, semen ziziphi spinosae, lily, dried orange peel, the root of Dahurain angelica.
6. constipation tailored version clinical nutrition formula according to claim 4 or 5, which is characterized in that the integration of drinking and medicinal herbs at The parts by weight of cassia seed, endothelium corneum gigeriae galli, radish seed, dandelion, brush-cherry seed, peach kernel in point are as follows: 0.1-1 parts of cassia seed, endothelium corneum gigeriae galli 0.1-1 parts, 0.1-1 parts of radish seed, 0.1-1 parts of dandelion, 0.1-1 parts of brush-cherry seed, 0.1-1 parts of peach kernel.
7. constipation tailored version clinical nutrition formula according to claim 1, which is characterized in that the lactobacillus includes acidophilus At least one of lactobacillus, lactobacillus plantarum, Lactobacillus rhamnosus.
8. constipation tailored version clinical nutrition formula according to claim 1, which is characterized in that the new resource food includes Chitosan oligosaccharide, circle luxuriant isapgol husk, Noni puree, lactobacillus acidophilus, lactobacillus plantarum, Lactobacillus rhamnosus, avenabeta glucosan.
9. constipation tailored version clinical nutrition formula according to claim 8, which is characterized in that shell in the new resource food Oligosaccharides, circle luxuriant isapgol husk, Noni puree, lactobacillus acidophilus, lactobacillus plantarum, Lactobacillus rhamnosus, avenabeta glucosan Parts by weight are as follows: chitosan oligosaccharide 0.1-0.5, circle luxuriant 3-5 parts of isapgol husk, 0.1-1 parts of Noni puree, lactobacillus acidophilus 0.01- 0.03 part, 0.01-0.02 parts of lactobacillus plantarum, 0.01-0.02 parts of Lactobacillus rhamnosus, 0.1-1 parts of avenabeta glucosan.
10. the preparation method of constipation tailored version clinical nutrition formula according to claim 1 to 9, feature exist In including the following steps:
Step 1, fat powder is prepared；
Step 2, integration of drinking and medicinal herbs ingredient and vitamin are prepared into powder particle diameter is 60~80 mesh powders；
Step 3, the carbohydrate of predetermined weight, dietary fiber, diet essence, natural plants compound and new resources are eaten Product are prepared into the powder that powder particle diameter is 150~250 μm respectively；
Step 4, powder obtained by step 1~3 is sequentially added into mixing machine and is uniformly mixed obtained formula mixture, by sterilization It is spare after processing；
Step 5, the formula mixture is prepared into nutrient powder, nutrition emulsion, capsule, tablet, pill or oral solution It is at least one；
Wherein, the sequence of step 1~3 can be replaced mutually.
CN201811237151.3A 2018-10-23 2018-10-23 Constipation tailored version clinical nutrition formula and preparation method thereof Pending CN109349618A (en)

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CN113318168A (en) * 2021-06-08 2021-08-31 深圳市龙岗区妇幼保健院 Composition for improving intractable constipation and application thereof
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