CN109601878A - For protecting the nutraceutical of injury of lungs - Google Patents

For protecting the nutraceutical of injury of lungs Download PDF

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Publication number
CN109601878A
CN109601878A CN201810892990.2A CN201810892990A CN109601878A CN 109601878 A CN109601878 A CN 109601878A CN 201810892990 A CN201810892990 A CN 201810892990A CN 109601878 A CN109601878 A CN 109601878A
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CN
China
Prior art keywords
powder
nutraceutical
injury
lungs
protecting
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CN201810892990.2A
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Chinese (zh)
Inventor
徐红涛
谷欣
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Tesoo Bio Tech Tianjin Co ltd
Original Assignee
Jiashi Rukang (beijing) Pharmaceutical Co Ltd
Li Rui Guest Information Technology (beijing) Co Ltd
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Priority to CN201810892990.2A priority Critical patent/CN109601878A/en
Publication of CN109601878A publication Critical patent/CN109601878A/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L13/00—Meat products; Meat meal; Preparation or treatment thereof
    • A23L13/20—Meat products; Meat meal; Preparation or treatment thereof from offal, e.g. rinds, skins, marrow, tripes, feet, ears or snouts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L25/00—Food consisting mainly of nutmeat or seeds; Preparation or treatment thereof
    • A23L25/30—Mashed or comminuted products, e.g. pulp, pastes, meal, powders; Products made therefrom, e.g. blocks, flakes, snacks; Liquid or semi-liquid products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Inorganic Chemistry (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention provides a kind of for protecting the nutraceutical of injury of lungs.The nutraceutical includes plant food materials and Saussurea involucrata culture of the content higher than 0.001% of Animal Skin source property food materials of the dry weight content higher than 40% of collagen, resveratrol.The nutraceutical provided by the invention has stronger injury of lungs protection effect, has significant protection effect especially for injury of lungs caused by haze.

Description

For protecting the nutraceutical of injury of lungs
Technical field
The present invention relates to technical field of functional food, in particular to a kind of for protecting the nutraceutical of injury of lungs.
Background technique
China in 2016 promulgate certain outline file indicate food and medicine industry should high speed development and in It is high-end to stride forward.In addition to this, compatriots begin to focus on health care very early, focus on slow to prevent and improve with dietotherapy, herbal cuisine etc. Rehabilitation course after venereal disease and acute pathological state maintains and promotes the health and rehabilitation of body.The tcm health preserving in China is managed By having proposed more than 5000 years, Huangdi's Internal Classics propose that " integration of drinking and medicinal herbs " and " preventiveing treatment of disease " theory also has more than 2000 years history, existing For the continuous development of clinical nutriology in the world, these are all contemporary functional food, special medicine purposes formula food The research of product, health food and drug (especially Chinese medicine class) provides valuable theoretical basis.
In recent years, as the fast development of industrial and agricultural production, transportation are increasingly flourishing, atmospheric environment is by additional dirt The influence of object is contaminated, especially the pollution of Atmospheric particulates is so that haze weather is more and more.PM2.5 haze can also known as enter lung Grain object, can enter blood by bronchus and alveolar, and the exchange of interference lung causes respiratory tract infection, injury of lungs and cancer Etc. a variety of diseases, people's health is endangered.Current study show that PM2.5 environmental pollution significantly affects respiratory disorder disease incidence, by It is deposited in alveolar in it, is easy to stimulate and corrode alveolar wall and generates inflammatory reaction, cause lung tissue structure's damage and function disorderly Disorderly, the defensive barrier and itself anti-weighing apparatus function of pulmonary macrophage are destroyed, lung function is reduced, leads to the significant increasing of respiratory disease Add, such as pneumonia, chronic bronchitis, chronic obstructive pulmonary disease, bronchial asthma, the respiratory systems such as cough, disease, asthma occurs in patient Symptom.
Based on the above reasons, exploitation has the nutraceutical task of top priority for being used to protect injury of lungs of daily health caring effect, However the specific aim of existing nutraceutical is not strong on the market at present, it is not good enough for the protection effect of injury of lungs.
Summary of the invention
The main purpose of the present invention is to provide a kind of for protecting the nutraceutical of injury of lungs, to solve in the prior art Not strong, not good enough for the protection effect of the injury of lungs problem of nutraceutical specific aim.
To achieve the goals above, according to an aspect of the invention, there is provided it is a kind of for protecting the nutrition of injury of lungs Food comprising the dry weight content of collagen is higher than 40% Animal Skin source property food materials, the content of resveratrol is higher than 0.001% plant food materials and Saussurea involucrata culture.
Further, Animal Skin source property food materials of the dry weight content of collagen higher than 40% are selected from donkey-hide gelatin, oxhide gelatin, sea One of ginseng and sharkskin are a variety of；It is preferred that plant food materials of the content of resveratrol higher than 0.001% are selected from Grape Skin, Portugal One of grape seed, mulberries and peanut are a variety of.
Further, by weight, the nutraceutical for protecting injury of lungs includes the dry of 2~10 parts of collagen Plant food materials and 1 of the content higher than 0.001% of Animal Skin source property food materials of the weight content higher than 40%, 1~5 part of resveratrol ~5 parts of Saussurea involucrata culture, the dry weight content further preferably including 3~5 parts of collagen are higher than 40% Animal Skin source Property food materials, 2~3 parts of resveratrol content be higher than 0.001% plant food materials and 1~2 part of Saussurea involucrata culture.
Further, the nutraceutical for protecting injury of lungs further includes water-soluble dietary fiber；Preferably, by weight Meter, further includes 0.2~2 part of water-soluble dietary fiber for protecting the nutraceutical of injury of lungs, more preferably includes 0.2~0.8 The water-soluble dietary fiber of part.
Further, water-soluble dietary fiber is soybean dietary fiber, polydextrose, pectin, xylo-oligosaccharide, oligomeric fruit One of sugar, isomalto-oligosaccharide, seaweed glue and inulin are a variety of.
Further, by weight, the nutraceutical for protecting injury of lungs further includes 0.1~0.5 part of functionality Nutrient, and functional nutrient element is VitAVitE, vitamin D, vitamin B1, vitamin B2, vitamin B6, dimension Raw element B12, pantothenic acid, niacin, folic acid, inositol, taurine, L-carnitine, Hongqu powder (red colouring agent), phytosterol, soybean lecithin, glycine, One of proline, histidine, arginine, curcumin, glutamine and beta glucan are a variety of.
Further, by weight, the nutraceutical for protecting injury of lungs further includes 0.05~0.5 part of mineral Matter.
Further, minerals be ferrous gluconate, zinc lactate, glycine zine, l threonic acid, calcium gluconate, One of magnesium lactate, manganese gluconate, sodium selenite, Se-enriched yeast and copper sulphate are a variety of.
Further, by weight, the nutraceutical for protecting injury of lungs further includes 0.5~2 part of fruit vegetable powder.
Further, fruit vegetable powder be banaina, mango powder, pineapple powder, jackfruit powder, durian powder, coconut meat powder, date palm powder, Lemon powder, litchi powder, longan powder, apple powder, date powder, pears powder, apricot powder, hawthorn powder, persimmon powder, orange powder, citrus powder, shaddock powder, peach Powder, strawberry powder, raspberry powder, mulberries powder, pomegranate powder, cherry powder, fig powder, blackcurrant powder, "Hami" melon powder, watermelon powder, pawpaw Powder, tomato meal, carrot meal, grape fruit powder, pumpkin powder, kiwi fruit powder, wolfberry fruit powder, seabuckthorn fruit powder, Cranberry powder, blueberry powder, A Sa One of her fruit powder, Lee's fruit powder, plum fruit powder, Chinese pear-leaved crabapple powder, Malus spectabilis fruit powder, Noni fruit powder and baobab fruit powder are a variety of.
The present invention provides a kind of for protecting the nutraceutical of injury of lungs comprising the dry weight content of collagen is higher than 40% Animal Skin source property food materials, the content of resveratrol are higher than 0.001% plant food materials and Saussurea involucrata culture.The present invention The nutraceutical provided has stronger injury of lungs protection effect, has especially for injury of lungs caused by haze significant Protection effect.
Specific embodiment
It should be noted that in the absence of conflict, the features in the embodiments and the embodiments of the present application can phase Mutually combination.Below in conjunction with embodiment, the present invention will be described in detail.
The application is described in further detail below in conjunction with specific embodiment, these embodiments should not be understood as limitation originally Apply for range claimed.
As described in background technology part, nutraceutical specific aim in the prior art is not strong, for injury of lungs Protection effect is not good enough.
To solve the above-mentioned problems, the present invention provides a kind of for protecting the nutraceutical of injury of lungs comprising collagen The dry weight content of albumen higher than 40% Animal Skin source property food materials, resveratrol content higher than 0.001% plant food materials with And Saussurea involucrata culture.Property food materials in Animal Skin source refer to edible animal skin or through edible animal skin through tanning formation herein Food materials.Animal Skin source property food materials of the dry weight content of collagen higher than 40% have effects that moistening lung, moisturize, especially for big Pulmonary function injury caused by particle (such as the bulky grain etc. in haze, flue dust) has good protective action, can also mitigate thin The inflammatory reaction of alveolar and macrophage caused by particle.Resveratrol can effectively slow down lung function degeneration, and it is thin to repair lung Cellular damage, and generate for effectively breathing vital surfactant.Addition is cooperateed in nutraceutical provided by the invention The content of Animal Skin source property food materials of the dry weight content of collagen higher than 40% and resveratrol is higher than 0.001% plant Food materials, auxiliary addition Saussurea involucrata culture have the injury of lungs of the initiations such as injury of lungs, especially haze, flue dust effective anti- Shield effect.
In a preferred embodiment, Animal Skin source property food materials of the dry weight content of collagen higher than 40% are selected from One of donkey-hide gelatin (colloid that donkey hide is formed through tanning), oxhide gelatin (colloid that ox-hide is formed through tanning), sea cucumber and sharkskin Or it is a variety of；It is preferred that plant food materials of the content of resveratrol higher than 0.001% are in Grape Skin, grape pip, mulberries and peanut It is one or more.Compared to other Animal Skin source property food materials and plant food materials, above-mentioned several food materials are selected, in addition to can be into one Step improves the effect of protection injury of lungs, also helps whole raising immunity of organisms.
In order to further improve the overall efficacy of nutraceutical, in a preferred embodiment, by weight, use It is eaten in Animal Skin source property of the dry weight content higher than 40% that the nutraceutical of protection injury of lungs includes 2~10 parts of collagen Material, 1~5 part of resveratrol content be higher than 0.001% plant food materials and 1~5 part of Saussurea involucrata culture, further preferably The content of Animal Skin source property food materials of the dry weight content including 3~5 parts of collagens higher than 40%, 2~3 parts of resveratrol Plant food materials and 1~2 part of Saussurea involucrata culture higher than 0.001%.
In a preferred embodiment, the nutraceutical for protecting injury of lungs further includes water-soluble dietary fiber； Preferably, by weight, the nutraceutical for protecting injury of lungs further includes 0.2~2 part of water-soluble dietary fiber, more excellent Choosing includes 0.2~0.8 part of water-soluble dietary fiber.Water-soluble dietary fiber is added, also helping improves body metabolism ability, Injury of lungs protection is also a supporting role.Meanwhile being conducive to improve it between other components using water-soluble dietary fiber Mixing dispersibility.Preferably, water-soluble dietary fiber be soybean dietary fiber, it is polydextrose, pectin, xylo-oligosaccharide, oligomeric One of fructose, isomalto-oligosaccharide, seaweed glue and inulin are a variety of.
In a preferred embodiment, by weight, the nutraceutical for protecting injury of lungs further include 0.1~ 0.5 part of functional nutrient element, and functional nutrient element is VitAVitE, vitamin D, vitamin B1, vitamin It is B2, vitamin B6, vitamin B12, pantothenic acid, niacin, folic acid, inositol, taurine, L-carnitine, Hongqu powder (red colouring agent), phytosterol, big One of Fabaceous Lecithin, glycine, proline, histidine, arginine, curcumin, glutamine and beta glucan are a variety of.Add Enter above-mentioned functional nutrient element, the nutrition for being conducive to further increase above-mentioned nutraceutical is comprehensive, supplements for human body necessary Nutriment.
In a preferred embodiment, by weight, the nutraceutical for protecting injury of lungs further includes 0.05 ~0.5 part of minerals.Minerals and vitamins are the same, are the necessary elements of human body, and minerals are itself can not to generate, close At, therefore adding above-mentioned minerals in above-mentioned nutraceutical can be body supplement minerals appropriate, be further ensured that battalion Support the intake of element.Preferably, minerals include but is not limited to ferrous gluconate, zinc lactate, glycine zine, L- threonic acid One of calcium, calcium gluconate, magnesium lactate, manganese gluconate, sodium selenite, Se-enriched yeast and copper sulphate are a variety of.
In a preferred embodiment, by weight, the nutraceutical for protecting injury of lungs further include 0.5~ 2 parts of fruit vegetable powder.Preferably, fruit vegetable powder is banaina, mango powder, pineapple powder, jackfruit powder, durian powder, coconut meat powder, date palm Powder, lemon powder, litchi powder, longan powder, apple powder, date powder, pears powder, apricot powder, hawthorn powder, persimmon powder, orange powder, citrus powder, shaddock powder, Peach powder, strawberry powder, raspberry powder, mulberries powder, pomegranate powder, cherry powder, fig powder, blackcurrant powder, "Hami" melon powder, watermelon powder, wood Melon powder, tomato meal, carrot meal, grape fruit powder, pumpkin powder, kiwi fruit powder, wolfberry fruit powder, seabuckthorn fruit powder, Cranberry powder, blueberry powder, Ah One of Say fruit powder, Lee's fruit powder, plum fruit powder, Chinese pear-leaved crabapple powder, Malus spectabilis fruit powder, Noni fruit powder and baobab fruit powder are a variety of.Fruit Vegetable powder is rich in various inoxidizability nutrients, vitamin, dietary fiber, carbohydrate and natural flavour mountaineous substance etc., in addition Fruit vegetable powder is stated, the flavor and the nutrition that further increase above-mentioned nutraceutical are conducive to.
It optionally, further include 20~200 parts of grain dust in above-mentioned nutraceutical.It should be noted that above-mentioned " grain dust " Refer to full grain dust or the pure white grain dust without wheat bran and germ fraction.In grain dust containing carbohydrate, protein, Inorganic salts and a small amount of fat and B family vitamin can supply the necessary energy of human body, protein and a small amount of applied to the present invention Minerals, vitamins and other nutritious components.In a preferred embodiment, grain dust is rice flour, corn flour, milled glutinous broomcorn millet One of powder, sorghum rice flour, corn flour, wheat flour, pearling cone meal, oatmeal and highland barley flour are a variety of.Preferably rice flour and/ Or corn flour.Rice flour can be rice meal, long rice flour, polished rice powder, purple rice powder, black rice flour, glutinous rice flour etc., and corn flour is as small Rice flour.
The specific preparation process of above-mentioned nutraceutical is simple, need to only mix each ingredient, and only needing respectively will be corresponding Raw material freeze-drying or drying, grinding, can be powdery appearance, can also be presented respectively by squeezing the modes such as moulding, 3D printing Kind moulding, such as: class rice type etc..When above-mentioned nutraceutical is powdery, especially grain dust, fruit vegetable powder content be zero or When less, it is also particularly suitable for being sold to relevant food as the core material of other food (functional staple food, functional beverage) Enterprise uses, and continues to add more grain dusts, fruit vegetable powder or other compositions, manufacture new formula, neomorph functional food or Beverage.
Specific preparation method can be such that
Powdered food: all raw materials after pulverizing raw material sieving granulation: are crossed into 60~12500 mesh Shai Zhi respectively Grain, is then stirred, obtains the granulated nutraceutical of ultra micro system；
3D appearance food: it is raw material by above-mentioned uniformly mixed powdered food, adds grain dust thereto, can also add suitable When the food additives of type, feeding, there is the extrusion moulding machine of class 3D printing principle to beat under relevant temperature and pressure parameter After being printed as shape, it is peeled into rice-shaped；Then it dries, obtains the nutraceutical of 3D appearance.
Beneficial effects of the present invention are further illustrated by the following examples:
The nutraceutical for being used to protect injury of lungs that ingredient is different, proportion is different is provided in each embodiment, in addition to containing Have other than the millet flour that weight percentage is 90%, remaining each ingredient and its dosage (by weight) are shown in Table 1 and 2:
Table 1
Table 2
Comparative example 1
It is formulated with embodiment 12, the difference is that, it is not added with donkey-hide gelatin.
Comparative example 2
It is formulated with embodiment 12, the difference is that, it is not added with Grape Skin.
Comparative example 3
It is formulated with embodiment 12, the difference is that, it is not added with Saussurea involucrata culture.
Effect experiment:
One, material and method
1, material
Experimental animal
Healthy ICR female mice 60,25~27g of weight.At 22~28 DEG C of temperature, the cleaning of relative humidity 50~60% It is raised in environment, 5 cages, using 12/12 illumination.
Sample
Nutraceutical in embodiment 1~12, comparative example 1 to 3 carries out 0.9% physiological saline and brews, and every 25ml contains nutrition Food 1g, gastric infusion.
Collection point of the fourth ring road in Beijing as this experiment PM2.5 is chosen, acquisition time is winter in 2015.This research is adopted Instrument TEOM 1400a, ACCU and PM2.5 cutter are surveyed with Anderson type particle sampler HBL-GUV, the real-time basket of particulate matter It is used cooperatively, sampling membrane is clean stone cottonrose hibiscus fibrous filter membrane, is sampled with ready filter membrane.It has recorded near sampled point The variation of meteorologic parameter mainly has temperature, relative humidity, wind direction, wind speed and precipitation etc., replaces a filter membrane for 24 hours, removes filter Film skilful (in dirt faces) is put into the hermetic bag for the number of finishing, is saved in 4 DEG C of refrigerators of postposition, spare.
250ml deionized water is poured into brown, wide-mouth bottle, quartz film is soaked unrestrained.Wide-mouth bottle equipped with quartz film is placed on In ultrasonic vibration machine, 40min × 3 time are fullyd shake, eluting particles object.Liquid is shaken through eight layers of filtered through gauze, and by quartz film institute The deionized water of band sufficiently squeezes filtering, takes filtrate.The dry, evaporation by the vacuum dried machine of 3 bottles of filtrates, after drying PM2.5 is made into required concentration, 6mg/ml with physiological saline.PM2.5 suspension is deposited in standby in 4 DEG C of environment through high pressure sterilization 15min With with preceding sonic oscillation 5min so that particulate matter mixes.
PM2.5 causes mouse lung Establishing an injured model and grouping
Healthy ICR female mice 340 is randomly divided into 17 groups by weight: Normal group, model control group, embodiment 1 To 12, comparative example, 1 to 3 group, every group 20.In addition to Normal group, remaining each group is fabricated to PM2.5 and causes model of lung injury. Animal Model is as follows: the raising of the equal adaptability of each group one week.Blank control group: respectively at the 8th, 14,20 He of model foundation 26 days via intranasal applications instill 0.9% physiological saline (20 μ l/ are only), remaining time normally raises.Model control group: it is instiled using nasal cavity PM2.5 suspension method, respectively at the PM2.5 suspension that model foundation via intranasal application instillation in the 8th, 14,20 and 26 day prepares, 40mg/ Kgbw is calculated by 30g weight, and about 1.2mg/20 μ l/ only, put to death in 48 hours after contaminating by last time.Embodiment 1 to 12, 1 to 3 group of comparative example: the same model control group of method for establishing model.
Administration route and method
Blank control group, model control group: from modeling, 0.9% 0.2ml//d of physiological saline of administered by oral gavage, even It is 3 weeks continuous.Embodiment 1 to 12,1 to 3 group of comparative example: from modeling, respectively administered by oral gavage embodiment 1 to 12, comparative example 1 to 0.9% physiological saline of nutraceutical in 3 groups, 0.2ml//d, continuous 3 weeks.
Pulmonary function detection
(1) 1% amobarbital intraperitoneal injection of anesthesia mouse (0.15ml/30g), making it, deep is anaesthetized as far as possible, in order to avoid independently Breathing is mutually resisted with ventilator, influences result；
(2) it taking dorsal position garden due to station, cuts off skin of neck with tissue shear, tissue clamps chorista exposes tracheae, And blunt separation tracheae；
(3) a kerf, about 1.0mm are cut at the nearly head of tracheae, tracheae will be inserted at the gas-tpe fitting of intubation, it is solid with cotton thread It is fixed.
(4) transfer mouse to body retouches instrument platform；
(5) assisted respiartion machine and gas-tpe fitting are connected；
(6) lung function RLMax, ReMax, RLArea, ReArea, CdynMax, CdynArea, the PEF etc. for recording mouse refer to Target variation.(air-breathing/breath pressure of experimental animal has ventilator offer, makes to keep constant state).
Statistical analysis
All data are all made of 20.0 statistical analysis software of SPSS and carry out statistical procedures.
Experimental result
Long-term sucking PM2.5 can stimulate the recurrent exerbation of respiratory inflammation, cause damage-repair process constantly to carry out, instead Multiple inflammatory damage-reparation causes scar to be formed, and causes airway constriction to further cause airway resistance increase, occurs under lung function Drop, even results in COPD.Pulmonary function detection can preferably evaluate the degree of flow limitation.RLMax,ReMax,RLArea, ReArea is the good index for detecting flow limitation and airway resistance, and PEF can preferably react small airway function, to small airway gas It is higher to flow limited sensibility.Carrying out animal lung function test helps to evaluate the air flue function that PM2.5 causes model of lung injury mouse Situation of change, the inspiratory resistance and expiratory resistance of this experimental studies results display model control group are significantly greater than blank control group (P < 0.05), air flue compliance and firmly maximum expiratory flow rate are decreased obviously (P < 0.05) compared with blank control group；Embodiment 1 to 12, the inspiratory resistance and expiratory resistance of 1 to 3 group of comparative example are significantly less than model control group (P < 0.05), air flue comply with domestic animal and Firmly maximum expiratory flow rate rises (P < 0.05) compared with model control group.As a result it see the table below:
Table 3
RLMax ReMax CdynMax RLArea ReArea CdynArea PEF
Blank control group 9.13 7.76 20.31 9.21 8.34 16.11 19.76
Model control group 19.87 19.26 4.43 18.97 16.30 7.30 5.61
Embodiment 1 8.52 8.24 19.22 9.55 9.70 15.73 18.73
Embodiment 2 8.71 8.47 19.07 9.73 9.82 15.95 18.49
Embodiment 3 8.84 8.38 19.10 9.71 9.81 15.46 18.56
Embodiment 4 8.76 8.53 19.14 9.69 9.86 15.79 18.53
Embodiment 5 8.77 8.58 19.12 9.69 9.87 15.54 18.52
Embodiment 6 8.81 8.51 19.22 9.67 9.79 15.49 18.47
Embodiment 7 8.99 8.10 19.46 9.57 9.60 15.74 18.90
Embodiment 8 8.92 8.15 19.43 9.47 9.52 15.79 18.92
Embodiment 9 8.93 8.14 19.47 9.50 9.47 15.77 18.91
Embodiment 10 8.90 8.23 19.56 9.52 9.60 15.84 18.95
Embodiment 11 8.92 8.18 19.43 9.47 9.43 15.80 18.80
Embodiment 12 8.98 8.15 19.49 9.53 9.52 15.85 18.96
Comparative example 1 12.22 15.16 8.42 14.92 13.31 10.30 7.69
Comparative example 2 14.27 15.28 8.13 12.90 13.11 9.87 8.90
Comparative example 3 14.80 15.71 7.97 16.95 14.00 9.02 10.65
The result shows that PM2.5 causes injury of lungs animal model mouse, there are ventilatory functions to be limited, especially the function of small airway A possibility that obstacle, airway resistance obviously increase, and there are airway obstructions；After nutraceutical provided by the invention protection, mouse Lung function improved, be mainly shown as the reduction of airway resistance, the increase of air flue compliance.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, made any to repair Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.

Claims (10)

1. a kind of for protecting the nutraceutical of injury of lungs, which is characterized in that described for protecting the nutraceutical packet of injury of lungs The content of Animal Skin source property food materials of the dry weight content higher than 40%, resveratrol that include collagen is higher than 0.001% plant Food materials and Saussurea involucrata culture.
2. according to claim 1 for protecting the nutraceutical of injury of lungs, which is characterized in that the collagen is done The Animal Skin source property food materials that weight content is higher than 40% are selected from one of donkey-hide gelatin, oxhide gelatin, sea cucumber and sharkskin or a variety of；It is preferred that Plant food materials of the content of the resveratrol higher than 0.001% be selected from one of Grape Skin, grape pip, mulberries and peanut or It is a variety of.
3. according to claim 2 for protecting the nutraceutical of injury of lungs, which is characterized in that by weight, described Nutraceutical for protecting injury of lungs includes that the dry weight content of 2~10 parts of the collagen is higher than 40% Animal Skin source Property food materials, 1~5 part of the resveratrol content higher than 0.001% plant food materials and 1~5 part the saussurea involucrata culture Object, further preferably Animal Skin source property food materials of the dry weight content including 3~5 parts of the collagen higher than 40%, 2~3 The content of the resveratrol of part is higher than 0.001% plant food materials and 1~2 part of the Saussurea involucrata culture.
4. according to claim 3 for protecting the nutraceutical of injury of lungs, which is characterized in that described for protecting lung to damage The nutraceutical of wound further includes water-soluble dietary fiber；Preferably, by weight, described for protecting the nutrition of injury of lungs to eat Product further include 0.2~2 part of the water-soluble dietary fiber, and more preferably the aqueous soluble dietary including 0.2~0.8 part is fine Dimension.
5. according to any one of claim 1 to 4 for protecting the nutraceutical of injury of lungs, which is characterized in that described Water-soluble dietary fiber is soybean dietary fiber, polydextrose, pectin, xylo-oligosaccharide, oligofructose, isomalto-oligosaccharide, sea One of phycocolloid and inulin are a variety of.
6. according to any one of claim 1 to 4 for protecting the nutraceutical of injury of lungs, which is characterized in that by weight Measure part meter, the nutraceutical for protecting injury of lungs further includes 0.1~0.5 part of functional nutrient element, and the function Property nutrient be VitAVitE, vitamin D, vitamin B1, vitamin B2, vitamin B6, vitamin B12, pantothenic acid, Niacin, folic acid, inositol, taurine, L-carnitine, Hongqu powder (red colouring agent), phytosterol, soybean lecithin, glycine, proline, histidine, One of arginine, curcumin, glutamine and beta glucan are a variety of.
7. according to any one of claim 1 to 4 for protecting the nutraceutical of injury of lungs, which is characterized in that by weight Part meter is measured, the nutraceutical for being used to protect injury of lungs further includes 0.05~0.5 part of minerals.
8. according to claim 7 for protecting the nutraceutical of injury of lungs, which is characterized in that the minerals are grape Saccharic acid ferrous iron, zinc lactate, glycine zine, l threonic acid, calcium gluconate, magnesium lactate, manganese gluconate, sodium selenite, richness One of selenium yeast and copper sulphate are a variety of.
9. according to claim 7 for protecting the nutraceutical of injury of lungs, which is characterized in that by weight, described Nutraceutical for protecting injury of lungs further includes 0.5~2 part of fruit vegetable powder.
10. according to claim 7 for protecting the nutraceutical of injury of lungs, which is characterized in that the fruit vegetable powder is perfume Any of several broadleaf plants powder, mango powder, pineapple powder, jackfruit powder, durian powder, coconut meat powder, date palm powder, lemon powder, litchi powder, longan powder, apple powder, Date powder, pears powder, apricot powder, hawthorn powder, persimmon powder, orange powder, citrus powder, shaddock powder, peach powder, strawberry powder, raspberry powder, mulberries powder, pomegranate Powder, cherry powder, fig powder, blackcurrant powder, "Hami" melon powder, watermelon powder, papaya powder, tomato meal, carrot meal, grape fruit powder, pumpkin Powder, kiwi fruit powder, wolfberry fruit powder, seabuckthorn fruit powder, Cranberry powder, blueberry powder, A Sayi fruit powder, Lee's fruit powder, plum fruit powder, Chinese pear-leaved crabapple powder, One of Malus spectabilis fruit powder, Noni fruit powder and baobab fruit powder are a variety of.
CN201810892990.2A 2018-08-07 2018-08-07 For protecting the nutraceutical of injury of lungs Pending CN109601878A (en)

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Application publication date: 20190412