CN108850913A - One kind special medicine purposes formula food of diabetes containing prebiotics and preparation method thereof - Google Patents
One kind special medicine purposes formula food of diabetes containing prebiotics and preparation method thereof Download PDFInfo
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- CN108850913A CN108850913A CN201810564017.8A CN201810564017A CN108850913A CN 108850913 A CN108850913 A CN 108850913A CN 201810564017 A CN201810564017 A CN 201810564017A CN 108850913 A CN108850913 A CN 108850913A
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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Abstract
The invention belongs to special medicine technical field of food production, and in particular to one kind special medicine purposes formula food of diabetes containing prebiotics and preparation method thereof.The food includes following component and its percentage：Yam flour 15%-40%, lactalbumin 11-15%, resistant dextrin 10%-14%, walnut powder 8%-12%, xylitol 8%-12%, complex peptides powder 12%-20%, L-arabinose 5%-9%, inulin 5%-9%, 95 powder 4%-8% multi-vitamins 0.80-1.0 ‰ of xylo-oligosaccharide, composite mineral matter 4.0-4.5 ‰, further include Bitter Melon P.E 2%-6% and Herb Gynostemmae Pentaphylli extract 1%-5%.Blood glucose can not only be effectively reduced in the present invention, and has and improve diabetic mice anti-oxidation stress ability and mitigate Lipotoxicity, can play the role of protecting pancreatic tissue.
Description
Technical field
The invention belongs to special medicine technical field of food production, and in particular to a kind of special medicine of diabetes containing prebiotics
Purposes formula food and preparation method thereof.
Background technique
Diabetes be because insulin secretion or effect defect caused by hyperglycemia metabolic disease.Diabetes easily cause
A series of metabolic disorders such as patient's sugar, protein, fat, water and electrolyte, show as diuresis, weight loss, before the meal hypoglycemia,
Pruitus and infection, visual impairment, nervous system lesion etc..Evert etc. points out that the health objectives of maturity-onset diabetes patient are
It is blood glucose < 7%, blood pressure < 140/80mmHg, triglycerides < 150mg/L, low density lipoprotein cholesterol < 100mg/L, highly dense
Spend lipoprotein cholesterol > 40mg/L (male) and > 50mg/L (women).China GB 29922-2013《Food safety country
Standard special medicine purposes formula food general rule》Regulation, the full nutrition formula food of simple diabetic need to meet low glycemic
Index GI≤55, saturated fatty acid energy supply ratio≤10%, carbohydrate energy supply ratio 30%~60%, dietary fiber content >=
0.3g/100kJ, 7~42mg/100kJ of sodium content, can also be properly added chromium, water-soluble dietary fiber.
In order to preferably improve the functional components that patient's holistic health is horizontal, is metabolized at present about improvement diabetic
It is gradually concerned, and considers to be added in diabetes full nutrition formula food.Cavazza is the study found that gamma-Linolenic acid and at least
A kind of alkanoyl-L-carnitine (such as acetyl-L-carnitine) can be applied to special doctor's food of diabetic.The researchs such as Yimam hair
Existing, special doctor's food containing Aloesin has the fasting blood-glucose, human plasma insulin and the fructose amine level that reduce diabetic
Remarkable effect.Liu Ying is by multiple efficacies ingredients such as addition trivalent chromium, niacin, dietary fibers, using xylitol as sweetener generation
For sucrose, special doctor's food of suitable diabetic is developed using biofermentation technique, and passes through immunohistochemistry, islet tissue
Pathologic structure variation, islet tissue In situ cell apoptosis, Serologic test etc. are that the development of diabetes full nutrition formula food mentions
Theoretical foundation is supplied.Currently, external diabetes full nutrition formula food industry development comparatively perfect, and the domestic industry is still in
Initial stage has the potentiality that grow a lot.
EN support and nutrition treatment side of the exploitation of special medicine purposes formula food to clinical diabetes patient
There is very important effect in face.The existing formula food for diabetic is also very much, as Chinese patent application discloses
A kind of formula food suitable for patients with diabetes mellitus and preparation method thereof (201510057275.3), by buckwheat, wheat
Fiber, hawthorn, pueraria lobata, oligoisomaltose, xylitol, food additives, vitamin premix by refining, concentration, it is dry,
Mixing and etc. be made.Its blood glucose that can effectively reduce patient, the clinical symptoms of reduction of patient.But it cannot provide conjunction for patient
The protein requirement of reason, it is difficult to enhance the immunocompetence of patient, not be avoided that the generation of the complication such as coronary heart disease, nephrosis.In addition,
Domestic special medicine purposes formula food out newly developed is in control blood glucose, glucose in urine increases the stage, and there has been no be directed to people
The damage of body pancreatic tissue has repair special medicine purposes formula food.
Summary of the invention
To solve the above-mentioned problems, the present invention provides a kind of special medicine purposes formula food of diabetes containing prebiotics and
Preparation method.
To achieve the above object, the present invention uses following technical scheme：
One of the object of the invention provides a kind of special medicine purposes formula food of diabetes containing prebiotics, including below at
Point and its percentage：Yam flour 15%-40%, lactalbumin 11-15%, resistant dextrin 10%-14%, walnut powder 8%-
12%, xylitol 8%-12%, complex peptides powder 12%-20%, L-arabinose 5%-9%, inulin 5%-9%, xylo-oligosaccharide
95 powder 4%-8% multi-vitamins 0.80-1.0 ‰, composite mineral matter 4.0-4.5 ‰.
The two of the object of the invention provide the preparation side of the special medicine purposes formula food of diabetes containing prebiotics described in one kind
Method includes the following steps：
(1) Chinese yam, balsam pear, gynostemma pentaphylla are taken, is mixed, is crushed, is soaked in water, refluxing extraction, filter to obtain extracting solution, extracting solution
Extract dry powder can be obtained in concentrated, spray drying；
(2) the extract dry powder that step (1) is prepared and lactalbumin, walnut powder, complex peptides powder, L- are Arabic
Sugar, inulin, xylo-oligosaccharide, multi-vitamins and composite mineral matter mixing, stir evenly.
3) 70-80 DEG C of microwave disinfection, packaging to get.
Preferably, it is 20-30 mesh that the step (1), which crushes mesh number, and adding water water and smashing the mass ratio of mixture is 6-
8:1, soaking time 45-60min, reflux extracting time 40-50min.
The present invention containing prebiotics be suitable for diabetes special medicine purposes formula food formula, include carbohydrate,
The principle active components such as protein, fat, dietary fiber, vitamin, minerals.Wherein carbohydrate, protein, diet are fine
Dimension, vitamin and mineral meet China health industry standard WS/T429-2013《Maturity-onset diabetes patient's Appropriate dietary guide》It pushes away
It recommends.
Contain integration of drinking and medicinal herbs raw-food material in inventive formulation：Integration of drinking and medicinal herbs raw-food material with hypoglycemic effect, no
Only there is blood-sugar decreasing active, the nutritional ingredient necessary to body also containing there are many, such as protein, tartaric acid, vitamin, mineral
Matter, antioxidant etc., these ingredients are beneficial to the improvement of diabetes and its complication symptom.
Diabetic can be improved by Chinese herbal medicine, dietetic regulation, the stabilizing blood sugars such as movement conditioning, while repair pancreas islet
Damaged cell helps diabetes to reduce the dependence of drug.Specific full nutritional formulas can both meet target person when individually eating
The nutritional need of group, and can targetedly adapt to diabetes specific metabolic state.A kind of special doctor of diabetes containing prebiotics
Learning purposes formula food not only can satisfy the nutritional need of diabetic, but also its raw material also has following health benefits：
Xylitol：Belong to low glycemic index food, xylitol does not depend on insulin not only in the metabolism of human body, moreover it is possible to promote
The secretion of insulin, and do not increase blood glucose and glucose in urine, it is the good nutritional agents of diabetes patient and auxiliary therapeutical agent.
L-arabinose：It is a kind of sweetener of low energy, most representative physiological action is selectively to influence
The invertase of sucrose is digested in small intestine disaccharide-hydrolysing enzymes, thus inhibit the absorption of sucrose, blood caused by inhibiting because of intake sucrose
Sugar increases, especially significant in terms of enhancing sugar tolerance effect for protecting islet cells normal physiological function.In addition,
It can also inhibit fat, prevent and treat disease relevant to hyperglycemia.
Xylo-oligosaccharide：Can be proliferated Bifidobacterium, bifidobacterium fermentation generate some short chain fatty acids for example acetic acid, propionic acid,
Butyric acid etc., short chain fatty acids are absorbed the health environment that can improve gastrointestinal tract, the adjustable liver carbon aquation of propionic acid by mucous membrane of colon
The metabolism of object is closed, sugar tolerance and insulin sensitivity situation in healthy women body are improved.Xylo-oligosaccharide can promote drug to inhale
It receives, improves its curative effect, be the supplementary food for the treatment of diabetes.However xylo-oligosaccharide compounds combination with raw materials such as integration of drinking and medicinal herbs and has
Blood sugar reducing function can produce better therapeutic effect.
Inulin：It will not be hydrolyzed into monosaccharide on the top of enteron aisle, because without increasing blood glucose level and insulin content.It grinds
Study carefully and shows that the reduction of fasting blood-glucose is the result of oligofructose short chain fatty acids caused by colon fermentation.After taking in inulin
Gastrointestinal motility can be enhanced, improve functions of intestines and stomach, increase digestion and appetite, improve immunity of organisms.May be used also in addition, eating inulin
Serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) is effectively reduced, improves high-density lipoprotein/low density lipoprotein
Protein ratios improve status of blood lipid.
Resistant dextrin：It can delay and inhibit digestion, absorption of the human body to carbohydrate, improve distal tissues to the quick of insulin
Perception reduces the demand to insulin.Water-soluble resistant dextrin can form gel, prevent carbohydrate from spreading, postpone it in the intestine
Absorption, thus inhibit carbohydrate absorb after blood glucose rising and the raised reaction of blood insulin.Disappear in addition, resistant dextrin can change
The secretion for changing road hormone reduces pancreatic secretion secretion, changes the digested enzyme of enteron aisle so that carbohydrate be inhibited to absorb and plays reduction blood glucose
Effect.
Complex peptides powder：It is full of nutrition and be easy to absorb containing Several Active Peptides.Wherein soybean peptide has enhancing phagocytosis
The vigor of cell and B cell enhances immune function, has anticancer, anti-aging, protection epidermal cell, elimination oxyradical etc.
Effect；And it can promote cell proliferation, protect liver, prevent cirrhosis, and facilitate the recovery of liver function, have to diabetes
Medical treatment and prevention effect.
Lactalbumin：Body make-up is provided and newly organizes required amino acid, delaying human body caducity；Enzyme is manufactured in vivo, is changed
Kind functions of intestines and stomach；It is immune system manufacture to the antibody of antibacterium and infection；Intracorporal moisture, electrolyte balance are adjusted, is enhanced
Body resisting fatigue ability；In addition, accelerating body reparation to cell delivery oxygen and various nutriments.
Walnut powder：With a variety of unsaturated and single non-saturated fatty acids, cholesterol level can be reduced.86% in walnut
Fat is unsaturated fatty acid, and lipase 37 1% is linoleic acid, and 12% is linolenic acid；Walnut rich in copper, magnesium, potassium, vitamin B6,
Folic acid and vitamin B1 also contain fiber, phosphorus, niacin, iron, vitamin B2 and pantothenic acid；Walnut has warm liver, kidney tonifying, brain tonic, strong
The functions such as muscle, bone strengthening.
Balsam pear：Bitter is cold in nature, has clearing heat and detoxicating, liver-kidney tonifying, the effect that relieving restlessness is quenched the thirst, and kind control is quenched one's thirst.It has confirmed
Balsam pear has the bioactivity of similar insulin, and fresh bitter extract has apparent hypoglycemic work to alloxan diabetes mouse
With blood-sugar decreasing active is soaping agents and polysaccharide compound and two kinds of non-saponins, flavones and alkaloids substance.
Gynostemma pentaphylla：It is bitter in taste, it trembles with fear, clearing heat and detoxicating, cough-relieving apophlegmatic reduces blood glucose, improves glycometabolism, and anticancer is anti-old, drops blood
Rouge.Animal experiment data shows that Herb Gynostemmae Pentaphylli extract has apparent hypoglycemic effect to alloxan diabetes mouse, and can be bright
It is aobvious to improve the low situation of senile rat sugar tolerance, it is suitable for the glycosuria of complicated hypertension, coronary heart disease, hyperlipidemia and obesity especially
Patient.
Chinese yam：Its nutriment and active constituent include mucoprotein, amino acid, allantoin, amylase, microelement, more
Sugar etc..Chinese yam mucilaginous substance and polysaccharide can stimulate and adjust the immune system of human body, reduce blood glucose, enhance the resistance of human body.It grinds
Study carefully and shows that Chinese yam has certain antidiabetic effect, the islet beta cell function that may be damaged with increase insulin secretion, improvement
It is related.Chinese yam has tonifying middle-Jiao and Qi effect, has the function of adjusting spleen and stomach function.
Vitamin：B family vitamin is supplemented, diabetic neuropathy can be improved；Vitamin B6 is body fat and glycometabolism
Necessary material, it is related with the metabolism of glycogen, sphingomyelin and steroids.Diabetic's Supplement of folic acid has and adjusts blood
Rouge reduces serium inorganic phosphorus effect；Vitamin K can also improve pancreas by vitamin k-dependent osteocalcin in addition to facilitating coagulation function
The sensibility of island element and the function of improving islet cells.Intake vitamin K plays the role of reducing diabetes risk；Vitamin D
Lack with diabetes have certain relationship, can by inhibit inflammatory reaction, adjust immunity of organism, promote insulin synthesis and
The occurrence and development that insulin sensitivity number of ways participates in disease are participated in secretion.Vitamin C can be with Scavenger of ROS (ROS)
With active nitrogen (RNS), lipid peroxidation is protected, improves fasting blood-glucose, glycosylated hemoglobin, total cholesterol and triacylglycerol water
It is flat.Vitamin E can mitigate vascular lesion caused by diabetes, prevent simultaneously delaying complications of diabetes especially cardiovascular complication
Generation.
Minerals：Chromium is microelement necessary to maintain normal sugar metabolism, and the compound that trivalent chromium is formed is referred to as
" glucose tolerance factor (GTF) ", can assist insulin maintenance normal glucose tolerance.Zinc can influence the synthesis of insulin, storage,
The integrality of secretion and structure adjusts insulin and acceptor levels, insulin-like effects is played in metabolism.Selenium can improve
Body impaired glucose tolerance has a degree of adjusting blood glucose to act on.After diabetic's selenium-supply, the lipid mistake in its blood is reduced
Oxide, so that the attack of its internal cardiac muscle cell, glomerulus and eye lens from oxygen radical, to prevent diabetes complicated
The generation of disease.Magnesium, which is the confactor of a variety of glycometabolism enzymes as cell activator, can protect the physiological function of beta Cell of islet,
Increase the quantity of insulin secretion and insulin receptor.Functional iron is present in hemoglobin, myoglobins and many enzymes, ginseng
With a series of metabolic processes.Diabetic's glycosylated hemoglobin increases, histanoxia, and serum levels of iron reduces.Manganese has with glycometabolism
It closes, research has shown that manganese deficiency pancreas development is not complete, impaired glucose tolerance, blood glucose rise, and sugared utilization rate reduces.
The beneficial effect that the present invention obtains：
The present invention selects the raw-food material, low glycemic index grain dust, cooperation of several integration of drinking and medicinal herbs low by scientific compatibility
The prebiotics such as xylan, compounding production can satisfy diabetes nutrition demand, and the product with assisting in reducing blood sugar effect.Its
In, the prebiotics such as xylo-oligosaccharide of addition give full play to bifidus factor effect, can dramatically increase intestinal probiotics quantity, match
Closing has integration of drinking and medicinal herbs raw-food material that is hypoglycemic, improving immunity, mitigates the side effect that Chinese medicine and Western medicine are taken, to realize
Integration of drinking and medicinal herbs food and probiotics cooperatively play the effect of auxiliary hyperglycemic.
The diabetes special medicine purposes formula food that the present invention is prepared can not only meet all kinds of nutriment need
It asks, and in good taste, has no toxic side effect, integration of drinking and medicinal herbs raw-food material abundance has natural hypoglycemic ingredient, preparation method letter
It is single, it can be produced on a large scale, there is preferable economic benefit and social benefit, can effectively improve diabetic population from diet
Nutritional need and metaboilic level.
In addition, blood glucose can not only be effectively reduced in the present invention special medicine purposes formula food of diabetes containing prebiotics, and
And GSH-Px, SOD activity in STZ diabetic mouse model pancreatic tissue can be increased, and ROS, MDA water can be reduced simultaneously
It is flat；The present invention special medicine purposes formula food of diabetes containing prebiotics have improve diabetic mice anti-oxidation stress ability with
And mitigate Lipotoxicity, it can play the role of protecting pancreatic tissue.
Specific embodiment
It is noted that described further below be all exemplary, it is intended to provide further instruction to the present invention.Unless another
It indicates, all technical and scientific terms used herein has usual with general technical staff of the technical field of the invention
The identical meanings of understanding.
It should be noted that term used herein above is merely to describe specific embodiment, and be not intended to restricted root
According to exemplary embodiments of the present invention.As used herein, unless the context clearly indicates otherwise, otherwise singular
Also it is intended to include plural form, additionally, it should be understood that, when in the present specification using term "comprising" and/or " packet
Include " when, indicate existing characteristics, step, operation and/or their combination.
Aiming at the problem that pointing out in background technique, the present invention provides one kind special medicine purposes of diabetes containing prebiotics to match
Square food, including following component and its percentage：Yam flour 15%-40%, lactalbumin 11-15%, resistant dextrin 10%-
14%, walnut powder 8%-12%, xylitol 8%-12%, complex peptides powder 12%-20%, L-arabinose 5%-9%, inulin
5%-9%, 95 powder 4%-8% multi-vitamins 0.80-1.0 ‰ of xylo-oligosaccharide, composite mineral matter 4.0-4.5 ‰.
Preferably, the special medicine purposes formula food of diabetes containing prebiotics is by following component and its percentage group
At：Yam flour 20%, lactalbumin 13%, resistant dextrin 12%, walnut powder 10%, xylitol 10%, complex peptides powder 15%, L-
Arabinose 6%, inulin 7%, 95 powder 7% of xylo-oligosaccharide, multi-vitamins 0.94 ‰, composite mineral matter 4.434 ‰.
Preferably, the special medicine of diabetes containing the prebiotics purposes formula food, further includes following component and its percentage
Than：Bitter Melon P.E 2%-6% and Herb Gynostemmae Pentaphylli extract 1%-5%.
Preferably, the special medicine of diabetes containing the prebiotics purposes formula food, by following component and its percentage group
At：Yam flour 15%, lactalbumin 12%, resistant dextrin 12%, walnut powder 10%, xylitol 10%, complex peptides powder 15%, L-
Arabinose 6%, inulin 7%, 95 powder 7% of xylo-oligosaccharide, Bitter Melon P.E 3%, Herb Gynostemmae Pentaphylli extract 3%, multi-vitamins
0.94 ‰, composite mineral matter 4.434 ‰.
Preferably, the multi-vitamins include vitamin E, vitamin B6, vitamin K, folic acid, vitamin D.
Preferably, vitamin E, vitamin B6, vitamin K, folic acid and vitamin D be in mass ratio in the multi-vitamins
0.4:0.2:0.07:0.05:0.03 composition.
Preferably, the composite mineral matter include Se-enriched yeast, magnesia, zinc gluconate, manganese sulfate, ferrous lactate and
Cr-enriched yeast.
Preferably, the composite mineral matter is by Se-enriched yeast, magnesia, zinc gluconate, manganese sulfate, ferrous lactate and richness
Chromium yeast by mass percentage 4:3:0.05:0.05:0.03:0.004 composition.
The two of the object of the invention provide the preparation side of the special medicine purposes formula food of diabetes containing prebiotics described in one kind
Method includes the following steps：
(1) Chinese yam, balsam pear, gynostemma pentaphylla are taken, is mixed, is crushed, is soaked in water, refluxing extraction, filter to obtain extracting solution, extracting solution
Extract dry powder can be obtained in concentrated, spray drying；
(2) the extract dry powder that step (1) is prepared and lactalbumin, walnut powder, complex peptides powder, L- are Arabic
Sugar, inulin, xylo-oligosaccharide, multi-vitamins and composite mineral matter mixing, stir evenly.
3) 70-80 DEG C of microwave disinfection, packaging to get.
Preferably, it is 20-30 mesh that the step (1), which crushes mesh number, and adding water water and smashing the mass ratio of mixture is 6-
8:1, soaking time 45-60min, reflux extracting time 40-50min.
In order to enable those skilled in the art can clearly understand technical solution of the present invention, below with reference to tool
The embodiment of the body technical solution that the present invention will be described in detail.
Embodiment 1
The special medicine of diabetes containing the prebiotics purposes formula food is made of following component and its percentage：Yam flour
20%, lactalbumin 13%, resistant dextrin 12%, walnut powder 10%, xylitol 10%, complex peptides powder 15%, L-arabinose
6%, inulin 7%, 95 powder 7% of xylo-oligosaccharide, multi-vitamins 0.94 ‰, composite mineral matter 4.434 ‰.
Vitamin E, vitamin B6, vitamin K, folic acid and vitamin D in mass ratio 0.4 in the multi-vitamins:
0.2:0.07:0.05:0.03 composition.
The composite mineral matter is by Se-enriched yeast, magnesia, zinc gluconate, manganese sulfate, ferrous lactate and Cr-enriched yeast
By mass percentage 4:3:0.05:0.05:0.03:0.004 composition.
The present embodiment formula food can significantly reduce diabetic mice FBG level, and diabetic mice pancreatic tissue can be improved
Middle GSH-Px, SOD content reduce ROS, and MDA is horizontal, but acts on not significant (being specifically detailed in test example).
Embodiment 2
In order to further increase the special medicine purposes formula food of diabetes containing prebiotics to the guarantor of diabetic mice pancreas
Shield effect, the present embodiment joined Bitter Melon P.E, Herb Gynostemmae Pentaphylli extract on the basis of embodiment 1 is formulated, specific ingredient and its
Percentage is as follows：Yam flour 15%, lactalbumin 11%, resistant dextrin 12%, walnut powder 10%, xylitol 10%, complex peptides
Powder 15%, inulin 7%, 95 powder 7% of xylo-oligosaccharide, Bitter Melon P.E 2%, Herb Gynostemmae Pentaphylli extract 5%, is answered at L-arabinose 6%
Close vitamin 0.94 ‰, composite mineral matter 4.434 ‰.
Vitamin E, vitamin B6, vitamin K, folic acid and vitamin D in mass ratio 0.4 in the multi-vitamins:
0.2:0.07:0.05:0.03 composition.
The composite mineral matter is by Se-enriched yeast, magnesia, zinc gluconate, manganese sulfate, ferrous lactate and Cr-enriched yeast
By mass percentage 4:3:0.05:0.05:0.03:0.004 composition.
Diabetic mice FBG is horizontal, improves GSH- in diabetic mice pancreatic tissue to reducing for the present embodiment formula food
Px, SOD content, reduce ROS, and MDA horizontal force is superior to embodiment 1 (being specifically detailed in test example).
In order to further improve the special medicine purposes formula food of diabetes containing prebiotics to the therapeutic efficiency of diabetes,
Each composition proportion is adjusted on the basis of embodiment 2 is formulated, obtains embodiment 3-4 formula food.
Embodiment 3
In order to further improve the special medicine purposes formula food of diabetes containing prebiotics to the therapeutic efficiency of diabetes,
Each composition proportion is adjusted on the basis of embodiment 2 is formulated, specific ingredient and percentage are as follows：
Yam flour 15%, lactalbumin 12%, resistant dextrin 12%, walnut powder 10%, xylitol 10%, complex peptides powder
15%, L-arabinose 6%, inulin 7%, 95 powder 7% of xylo-oligosaccharide, Bitter Melon P.E 3%, Herb Gynostemmae Pentaphylli extract 3%, compound
Vitamin 0.94 ‰, composite mineral matter 4.434 ‰.
Vitamin E, vitamin B6, vitamin K, folic acid and vitamin D in mass ratio 0.4 in the multi-vitamins:
0.2:0.07:0.05:0.03 composition.
The composite mineral matter is by Se-enriched yeast, magnesia, zinc gluconate, manganese sulfate, ferrous lactate and Cr-enriched yeast
By mass percentage 4:3:0.05:0.05:0.03:0.004 composition.
Diabetic mice FBG is horizontal, improves GSH- in diabetic mice pancreatic tissue to reducing for the present embodiment formula food
Px, SOD content, reduce ROS, and MDA horizontal force is significantly better than embodiment 1, is higher than
Embodiment 2,4, for the application most preferred embodiment (being specifically detailed in test example).
Embodiment 4
In order to further improve the special medicine purposes formula food of diabetes containing prebiotics to the therapeutic efficiency of diabetes,
Each composition proportion is adjusted on the basis of embodiment 2 is formulated, specific ingredient and percentage are as follows：
The special medicine of diabetes containing the prebiotics purposes formula food is made of following component and its percentage：Yam flour
15%, lactalbumin 11%, resistant dextrin 12%, walnut powder 10%, xylitol 10%, complex peptides powder 15%, L-arabinose
6%, inulin 7%, 95 powder 7% of xylo-oligosaccharide, Bitter Melon P.E 6%, Herb Gynostemmae Pentaphylli extract 1%, multi-vitamins 0.94 ‰, multiple
Close minerals 4.434 ‰.
Vitamin E, vitamin B6, vitamin K, folic acid and vitamin D in mass ratio 0.4 in the multi-vitamins:
0.2:0.07:0.05:0.03 composition.
The composite mineral matter is by Se-enriched yeast, magnesia, zinc gluconate, manganese sulfate, ferrous lactate and Cr-enriched yeast
By mass percentage 4:3:0.05:0.05:0.03:0.004 composition.
Diabetic mice FBG is horizontal, improves GSH- in diabetic mice pancreatic tissue to reducing for the present embodiment formula food
Px, SOD content, reduce ROS, and MDA horizontal force is superior to embodiment 1 (being specifically detailed in test example).
Embodiment 5
The preparation method of the special medicine of diabetes containing the prebiotics purposes formula food, includes the following steps：
(1) Chinese yam, balsam pear, gynostemma pentaphylla are taken, is mixed, is crushed, is soaked in water, refluxing extraction, filter to obtain extracting solution, extracting solution
Extract dry powder can be obtained in concentrated, spray drying；
The crushing mesh number is 20-30 mesh, and adding water water and smashing the mass ratio of mixture is 6-8:1, soaking time is
45-60min, reflux extracting time 40-50min.
(2) the extract dry powder that step (1) is prepared and lactalbumin, walnut powder, complex peptides powder, L- are Arabic
Sugar, inulin, xylo-oligosaccharide, multi-vitamins and composite mineral matter mixing, stir evenly.
3) 70-80 DEG C of microwave disinfection, packaging to get.
Test example
In order to probe into the 1 special medicine purposes formula food of diabetes containing prebiotics of the present embodiment to the improvement function of diabetes
Can, it is probed into using streptozotocin (STZ) induced diabetes mouse as model.
Diabetes mice model foundation：Mouse fasting 12h before modeling, test mice abdominal cavity STZ 150mg/kg.Eye after 72h
Fasting blood-glucose (FBG) is surveyed in endocanthion blood sampling, chooses the mouse of FBG >=11.1mmol/L as diabetes model.
Grouping and administration：Diabetic mice is randomly divided into 6 groups (every group 10)：Model group, melbine positive group and
Embodiment 1,4 test group of embodiment 2, embodiment 3 and embodiment.And set up normal group (10 healthy mices).
Test group gives corresponding Example formulations food 150mg/kg, and positive group is given melbine 50mg/kg, and normal group
And model group then gives same amount of normal saline, continued administration 14d.Eyeball, which is plucked, after fasting 12h before last dose, administration 1h takes blood,
Centrifuging and taking serum is to be measured.
Indexs measure：It is horizontal using glucose oxidase method detection fasting blood-glucose (FBG)；ELISA method detection pancreatic tissue
Middle GSH-Px, SOD, ROS, MDA content.
Test result：
(1) to the influence of diabetic mice FBG, test result is as shown in table 1.
Influence of 1 embodiment of table, 1 formula food to diabetic mice FBG
As shown in Table 1, the mouse FBG of model group and other administration groups is significantly raised before treating, and organizes significant difference with normal,
Illustrate modeling success.After treatment, melbine and embodiment 1-4 group of formula food can effectively reduce diabetic mice FBG level.
(2) horizontal to diabetic mice pancreas GSH-Px, SOD, ROS and MDA, test result is as shown in table 2.
Influence of 2 embodiment of table, 1 formula food to diabetic mice FBG
As shown in Table 2, GSH-Px in model group diabetic mice pancreatic tissue, SOD activity is decreased obviously, and ROS, MDA
Level increases, and there were significant differences compared with normal group.After administration, GSH-Px in example 1 group mice pancreatic tissue, SOD activity
It is promoted, ROS, MDA level is declined；And GSH-Px in 2 groups of mice pancreatic tissues of embodiment, SOD activity significantly rise,
ROS, MDA level are remarkably decreased.
Claims (10)
1. a kind of special medicine purposes formula food of diabetes containing prebiotics, which is characterized in that including following component and its percentage
Than：Yam flour 15%-40%, lactalbumin 11-15%, resistant dextrin 10%-14%, walnut powder 8%-12%, xylitol
8%-12%, complex peptides powder 12%-20%, L-arabinose 5%-9%, inulin 5%-9%, 95 powder 4%-8% of xylo-oligosaccharide
Multi-vitamins 0.80-1.0 ‰, composite mineral matter 4.0-4.5 ‰.
2. the special medicine of diabetes containing prebiotics purposes formula food according to claim 1, which is characterized in that by below at
Divide and its percentage forms：Yam flour 20%, lactalbumin 13%, resistant dextrin 12%, walnut powder 10%, xylitol 10%,
Complex peptides powder 15%, L-arabinose 6%, inulin 7%, 95 powder 7% of xylo-oligosaccharide, multi-vitamins 0.94 ‰, complex mineral
Matter 4.434 ‰.
3. the special medicine of diabetes containing prebiotics purposes formula food according to claim 1, which is characterized in that further include with
Lower ingredient and its percentage：Bitter Melon P.E 2%-6% and Herb Gynostemmae Pentaphylli extract 1%-5%.
4. according to claim 1 or the 3 special medicine purposes formula foods of diabetes containing prebiotics, which is characterized in that by with
Lower ingredient and its percentage composition：Yam flour 15%, lactalbumin 12%, resistant dextrin 12%, walnut powder 10%, xylitol
10%, complex peptides powder 15%, L-arabinose 6%, inulin 7%, 95 powder 7% of xylo-oligosaccharide, Bitter Melon P.E 3%, gynostemma pentaphylla
Extract 3%, multi-vitamins 0.94 ‰, composite mineral matter 4.434 ‰.
5. -2, the 4 special medicine purposes formula food of diabetes containing prebiotics according to claim 1, which is characterized in that described
Multi-vitamins include vitamin E, vitamin B6, vitamin K, folic acid, vitamin D.
6. the special medicine of diabetes containing prebiotics purposes formula food according to claim 5, which is characterized in that described compound
Vitamin E, vitamin B6, vitamin K, folic acid and vitamin D in mass ratio 0.4 in vitamin:0.2:0.07:0.05:0.03
Composition.
7. -2, the 4 special medicine purposes formula food of diabetes containing prebiotics according to claim 1, which is characterized in that described
Composite mineral matter includes Se-enriched yeast, magnesia, zinc gluconate, manganese sulfate, ferrous lactate and Cr-enriched yeast.
8. the special medicine of diabetes containing prebiotics purposes formula food according to claim 7, which is characterized in that described compound
Minerals are by Se-enriched yeast, magnesia, zinc gluconate, manganese sulfate, ferrous lactate and Cr-enriched yeast by mass percentage 4:3:
0.05:0.05:0.03:0.004。
9. the preparation method of -4 special medicine purposes formula foods of diabetes containing prebiotics according to claim 1, feature
It is, includes the following steps：
(1) Chinese yam, balsam pear, gynostemma pentaphylla are taken, is mixed, is crushed, is soaked in water, refluxing extraction, filter to obtain extracting solution, extracting solution is through dense
Extract dry powder can be obtained in contracting, spray drying；
(2) the extract dry powder that step (1) is prepared and lactalbumin, walnut powder, complex peptides powder, L-arabinose, chrysanthemum
Powder, xylo-oligosaccharide, multi-vitamins and composite mineral matter mixing, stir evenly.
3) 70-80 DEG C of microwave disinfection, packaging to get.
10. the preparation method of the special medicine of diabetes containing prebiotics purposes formula food, feature exist according to claim 9
In,
It is 20-30 mesh that the step (1), which crushes mesh number, and adding water water and smashing the mass ratio of mixture is 6-8:1, soaking time
For 45-60min, reflux extracting time 40-50min.
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| CN109567152A (en) * | 2018-12-24 | 2019-04-05 | 西昌市正中食品有限公司 | A kind of low-sugar mooncake syrup and preparation method thereof |
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| CN114128862A (en) * | 2021-11-26 | 2022-03-04 | 榆林好婆姨农业科技有限公司 | Preparation method of walnut peptide powder in ultralow temperature environment |
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