CN101091720A - Health food with efficacy for preventing osteoporosis and preparation method - Google Patents
Health food with efficacy for preventing osteoporosis and preparation method Download PDFInfo
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- CN101091720A CN101091720A CN 200610027886 CN200610027886A CN101091720A CN 101091720 A CN101091720 A CN 101091720A CN 200610027886 CN200610027886 CN 200610027886 CN 200610027886 A CN200610027886 A CN 200610027886A CN 101091720 A CN101091720 A CN 101091720A
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Abstract
The present invention relates to a health-care food with function capable of preventing osteoporosis and its preparation method. Its composition includes 95-98% of tricalcium phosphate, 1.5-4.5% of astragalus triphenol and 1-5per mill of cholecalciferol. Besides, said invention also provides the concrete steps of its preparation method.
Description
Technical field
The present invention relates to a kind of health food and preparation method thereof, relate in particular to a kind of health food that contains the many calcium of polyphenol with efficacy for preventing osteoporosis.
Background technology
Osteoporosis be one worldwide, more and more cause the health problem that people pay attention to.About 200,000,000 people in the whole world suffer from osteoporosis at present, and its sickness rate has leapt to commonly encountered diseases, frequently-occurring disease the 7th.Deeply hurt the U.S., Europe and nearly 7,500 ten thousand people of Japan, and at US and European, annual nearly 2,300,000 cause fracture patients, approximately annual 23000000000 dollars of this medical expenses by osteoporosis, cause financial burden for society and individual, and cause patient's pain and deformity.
Nutritional survey with regard to the existing diet structure of China shows that resident's calcium intake is generally on the low side, only reaches 50% of recommended intake, is about 400-500mg every day.Add that plant food is main meals pattern, the absorbance of calcium is low, the almost whole nutrition problem that exists in life of calcium deficiency.Therefore, all to note the absorption of calcium up to the year of advanced in years from baby in one's infancy.It is emphasized that does not especially medically also have safe and effective radical cure method at present.Therefore developing the health food with efficacy for preventing osteoporosis is significant and vast market prospect.
The existing market calcium enriching substance mainly is divided into the three generations: the first generation adopts animal skeleton, shell, Margarita and chemical combination calcium carbonate etc. simply to process for raw material, the second filial generation product of replenishing the calcium belongs to the calcium of organic acid class, comprise calcium gluconate, calcium acetate, calcium citrate, calcium malate, calcium lactate etc., the replenish the calcium main component of product of the third generation is a l threonic acid, be ascorbic a kind of deep processed product, all exist problems such as absorption rate is low, Product Safety is unreliable.
Summary of the invention
The technical issues that need to address of the present invention are to disclose a kind of efficacy for preventing osteoporosis health food and preparation method thereof that has, to overcome the above-mentioned defective that prior art exists.
Component and weight percentage with efficacy for preventing osteoporosis health food of the present invention comprises:
Tricalcium phosphate 95-98%
Resvertrol 1.5-4.5%
Cholecalciferol 1-5 ‰
The preferred weight content that adopts is at the resvertrol more than 98%, and said resvertrol can adopt the commercially available prod, as the product of Hunan Hong Guang company;
The weight content of calcium is not less than 37.5% in the tricalcium phosphate;
The content of the cholecalciferol that is adopted is at 100,000 more than the iu.
Preparation method with efficacy for preventing osteoporosis health food of the present invention comprises the steps: each component is proportionally mixed, and promptly obtains having the health food of efficacy for preventing osteoporosis.
Of the present invention have the efficacy for preventing osteoporosis health food and can become any one dosage form according to known method preparation, and preferred dosage form is a capsule, and the content of calcium is more than 70mg in every capsules (200mg).
Active component resvertrol among the present invention has been proved and can have improved osteoporosis comprehensively, improves absorption and the deposition of ossein to calcium, promotes osteanagenesis, and bone density improving makes bone become hard flexible.The mineral supplements that contains calcium and phosphorus double nutrition source simultaneously obviously helps to improve the health of tissue and skeleton, has the bioavailability of height, so this product can effectively prevent and treat osteoporosis.The prescription that the present invention adopts has two-ways regulation human body bone attitude balance, replenishes the sclerotin that runs off, and improves absorption and the deposition of ossein to calcium, effects such as bone density improving.
Of the present invention to have the efficacy for preventing osteoporosis health food be a kind of oral health food, and general consumption is a 0.8-1.2 gram/sky 60kg body weight.
Animal experiment proves, of the present invention have the efficacy for preventing osteoporosis health food and do not have toxicity, even take in a large number, also can not have side effects.
Good effect of the present invention is:
1) effectively improve the osteoporosis that the women causes because of estrogen decrease, and can take for a long time, the absorbance height, safety is good; 2) preparation is simple, and production cost is low, environmentally safe.
The specific embodiment
Embodiment 1
With weight purity is resvertrol more than 98%, and the calcium weight content is at the tricalcium phosphate more than 37.5% and the iu cholecalciferol at 100,000 IU, according to weight rate:
1.5: 98: 0.5 abundant mixings, make capsule, the content of calcium is more than 70mg in every capsules.
Implementation result:
With the mixture feeding mice in the capsule, the human body recommended amounts is 1.2g/60kg body weight every day, and basic, normal, high three dosage groups are established in test: each group is 0.1g, 0.2g, 0.6g/kg respectively, is equivalent to 5 times, 10 times, 30 times of human body recommended dose.Set up the blank group simultaneously.Thigh bone weight, tensile strength, the skeleton density index of test mice, result of the test shows its effectively prevention of osteoporosis, improves bone strength.
The result is as follows:
| Group | Number of animals (only) | Thigh bone weight (mg) | Tensile strength (1b) | Skeleton density (g/cm 2) |
| The blank group | 10 | 50±0.32 | 1.1±0.15 | 0.02±0.004 |
| Low dose group | 10 | 168±0.29 | 3.6±0.21 | 0.08±0.004 |
| Middle dosage group | 10 | 171±0.25 | 3.9±0.18 | 0.09±0.0035 |
| High dose group | 10 | 175±0.31 | 4.0±0.22 | 0.1±0.0042 |
P＜0.05 (through variance analysis)
As seen from the above table, the high, medium and low dosage group of sample Thigh bone weight, tensile strength and skeleton density are significantly higher than the blank group.Show that this laboratory sample has the prevention of osteoporosis effect.
Embodiment 2
With weight purity is resvertrol more than 98%, the calcium weight content is at the tricalcium phosphate more than 37.5% and the iu cholecalciferol at 100,000 IU, according to the abundant mixing of 4.5: 95: 0.1 ratio, make capsule, the content of calcium is more than 70mg in every capsules.
Implementation result: with the mixture feeding mice in the capsule, the human body recommended amounts is 1.2g/60kg body weight every day, and basic, normal, high three dosage groups are established in test: each group is 0.1g, 0.2g, 0.6g/kg respectively, is equivalent to 5 times, 10 times, 30 times of human body recommended dose.Set up the blank group simultaneously.Thigh bone weight, tensile strength, the skeleton density index of test mice, result of the test shows its effectively prevention of osteoporosis, improves bone strength.
The result is as follows:
| Group | Number of animals (only) | Thigh bone weight (mg) | Tensile strength (1b) | Skeleton density (g/cm 2) |
| The blank group | 10 | 49±0.28 | 1.1±0.15 | 0.02±0.0035 |
| Low dose group | 10 | 165±0.29 | 3.4±0.20 | 0.075±0.004 |
| Middle dosage group | 10 | 168±0.25 | 3.5±0.17 | 0.08±0.0035 |
| High dose group | 10 | 170±0.31 | 3.7±0.19 | 0.09±0.0041 |
P＜0.05 (through variance analysis)
As seen from the above table, the high, medium and low dosage group of sample Thigh bone weight, tensile strength and skeleton density are significantly higher than the blank group.Show that this laboratory sample has the prevention of osteoporosis effect.
Embodiment 3
With weight purity is resvertrol more than 98%, the calcium weight content is at the tricalcium phosphate more than 37.5% and the iu cholecalciferol at 100,000 IU, according to the abundant mixing of 3: 96.5: 0.5 ratio, make capsule, the content of calcium is more than 70mg in every capsules.
Implementation result: with the mixture feeding mice in the capsule, the human body recommended amounts is 1.2g/60kg body weight every day, and basic, normal, high three dosage groups are established in test: each group is 0.1g, 0.2g, 0.6g/kg respectively, is equivalent to 5 times, 10 times, 30 times of human body recommended dose.Set up the blank group simultaneously.Thigh bone weight, tensile strength, the skeleton density index of test mice, result of the test shows its effectively prevention of osteoporosis, improves bone strength.
The result is as follows:
| Group | Number of animals (only) | Thigh bone weight (mg) | Tensile strength (1b) | Skeleton density (g/cm 2) |
| The blank group | 10 | 50±0.32 | 1.1±0.15 | 0.02±0.004 |
| Low dose group | 10 | 169±0.27 | 3.5±0.20 | 0.085±0.003 |
| Middle dosage group | 10 | 170±0.20 | 3.8±0.19 | 0.09±0.0035 |
| High dose group | 10 | 172±0.28 | 4.0±0.21 | 0.11±0.004 |
P＜0.05 (through variance analysis)
As seen from the above table, the high, medium and low dosage group of sample Thigh bone weight, tensile strength and skeleton density are significantly higher than the blank group.Show that this laboratory sample has the prevention of osteoporosis effect.
Embodiment 4
To health food sampling carrying out acute toxicity test of the present invention, sample is obeyed LD50 all greater than 10000mg/kg to the acute oral of male and female white mice, with acute toxicity median lethal dose(LD 50) toxicity grading, belongs to nontoxic level material.
Claims (7)
1. have the efficacy for preventing osteoporosis health food, it is characterized in that, component and weight percentage comprise:
Tricalcium phosphate 95-98%
Resvertrol 1.5-4.5%
Cholecalciferol 1-5 ‰.
2. according to claim 1 have an efficacy for preventing osteoporosis health food, it is characterized in that, adopts weight content at the resvertrol more than 98%.
3. according to claim 1 have an efficacy for preventing osteoporosis health food, it is characterized in that the weight content of calcium is not less than 37.5% in the tricalcium phosphate.
4. according to claim 1 have an efficacy for preventing osteoporosis health food, it is characterized in that, the content of the cholecalciferol that is adopted is at 100,000 more than the iu.
5. each enforcement of claim 1～4 has an efficacy for preventing osteoporosis health food, it is characterized in that, is acceptable any one dosage form of field of health care food.
6. claim 5 is described has an efficacy for preventing osteoporosis health food, it is characterized in that acceptable any one dosage form of field of health care food is a capsule, and the content of calcium is more than 70mg in every capsules (200mg).
7. prepare each described method of claim 1-4, comprise the steps: each component is proportionally mixed, promptly obtain having the health food of efficacy for preventing osteoporosis with efficacy for preventing osteoporosis health food.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610027886 CN101091720A (en) | 2006-06-20 | 2006-06-20 | Health food with efficacy for preventing osteoporosis and preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610027886 CN101091720A (en) | 2006-06-20 | 2006-06-20 | Health food with efficacy for preventing osteoporosis and preparation method |
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| Publication Number | Publication Date |
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| CN101091720A true CN101091720A (en) | 2007-12-26 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200610027886 Pending CN101091720A (en) | 2006-06-20 | 2006-06-20 | Health food with efficacy for preventing osteoporosis and preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103565827A (en) * | 2013-11-07 | 2014-02-12 | 苏州冉新生物技术有限公司 | Resveratrol-containing tablets |
| CN103599096A (en) * | 2013-11-06 | 2014-02-26 | 苏州冉新生物技术有限公司 | Resveratrol tablet |
| CN105456621A (en) * | 2015-11-05 | 2016-04-06 | 郭珈宜 | Traditional Chinese medicated diet for preventing osteoporosis and preparation method thereof |
-
2006
- 2006-06-20 CN CN 200610027886 patent/CN101091720A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103599096A (en) * | 2013-11-06 | 2014-02-26 | 苏州冉新生物技术有限公司 | Resveratrol tablet |
| CN103565827A (en) * | 2013-11-07 | 2014-02-12 | 苏州冉新生物技术有限公司 | Resveratrol-containing tablets |
| CN105456621A (en) * | 2015-11-05 | 2016-04-06 | 郭珈宜 | Traditional Chinese medicated diet for preventing osteoporosis and preparation method thereof |
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Open date: 20071226 |