CN103638320A

CN103638320A - Traditional Chinese medicinal preparation for treating acute radiation-induced esophagitis

Info

Publication number: CN103638320A
Application number: CN201310722824.5A
Authority: CN
Inventors: 冯庆亮; 刘艳
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-12-15
Filing date: 2013-12-15
Publication date: 2014-03-19
Anticipated expiration: 2033-12-15
Also published as: CN103638320B

Abstract

The invention discloses a traditional Chinese medicinal preparation for treating acute radiation-induced esophagitis. In traditional Chinese medicine, radiation-induced esophagitis belongs to 'dysphagia', which is caused by intense toxic heat and impairment of fluid and qi due to radiation-induced toxic heat and body injury, or damage of collaterals in blood and stagnation of blood stasis. The traditional Chinese medicinal preparation is prepared from the following traditional Chinese medicines capable of clearing away heat and toxic materials, nourishing yin and promoting secretion of body fluid, promoting blood circulation and removing stasis, and promoting detumescence and resolving stasis: big striga herb, pteris nervosa, eyebright, asiatic plantain, Hippuris L, Chinese mahonia leaf, bornet cowlily rhizome, madder, nakedflower beautyberry branchlet and leaf and slenderscape amitostigma herb. The traditional Chinese medicinal composition is prepared into a decoction; a clinical test shows that total effective rate of the traditional Chinese medicinal composition is 98.0%; the traditional Chinese medicinal composition is good in curative effect and free from side reaction.

Description

A kind of Chinese medicine preparation for the treatment of acute radiation-induced esophagitis

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine preparation for the treatment of acute radiation-induced esophagitis.

Background technology

Radiotherapy is one of breast tumor primary treatment methods such as pulmonary carcinoma, the esophageal carcinoma and mediastinal tumor, aspect control malignant tumor progress, is playing an important role.Yet the radiotherapy irradiation field of breast tumor usually inevitably involves esophagus, thereby occurs acute radiation-induced esophagitis, to patient, cause very large misery, patient's the lighter Deficiency of Intake, severe one causes that nutrition is bad, electrolyte disturbance, even therapy discontinued, affects radiotherapy effect.Doctor trained in Western medicine only adopts the anti-inflammatory analgetic anti symptom treatment such as protectant of digestive tract mucosa dioctahedral smectite and antibiotic, glucocorticoid when symptom is obvious at present; although can alleviate to a certain extent patient's misery; but can not reduce this disease incidence rate, and have poisonous side effect of medicine.Radiotherapy is interrupted and treatment time prolongation can reduce therapeutic effect again.Chinese medicine prevention acute radiation-induced esophagitis not only curative effect is affirmed, is had no side effect but also be cheap, for improving body toleration, reduces the incidence rate of radiation esophagitis, and there is significant curative effect alleviating pain aspect.The traditional Chinese medical science is conceived to improve on the whole physical function, other whole body simultaneous phenomenons beyond acute radiation-induced esophagitis are also had some improvement as xerostomia, hoarseness, tired etc., the bone marrow depression that Radiotherapy chemotherapy is caused and feel sick, vomiting etc. has certain preventive and therapeutic action.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of acute radiation-induced esophagitis.Radiation esophagitis belongs to the traditional Chinese medical science " dysphagic " category more.Its pathogenesis is that the burning hot poison of lonizing radiation generation is evil, damage human body, flourishing, the cloudy Tianjin of intoxicating heat consumption wound; Or malicious blood trouble network, blood-stasis internal-depression.The traditional Chinese medical science is the rule for the treatment of mainly with heat-clearing and toxic substances removing, YIN nourishing and the production of body fluid promoting, blood circulation promoting and blood stasis dispelling and detumescence and promoting granulation.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment acute radiation-induced esophagitis is made by the Chinese medicine of following weight portion: Herba Strigae masuriae 15-25 part, Herba Pteridis multifidae 25-30 part, Herba Euphrasiae Regelii 3-9 part, Herba Plantaginis 9-15 part, Herba Hippuridis Vulgaris 6-12 part, Folium Mahoniae 6-9 part, Rhizoma Nupharis Bornetii 50-60 part, Radix Rubiae 6-9 part, Folium et Ramulus Callicarpae nudiflorae 15-25 part, Herba Amitostigmatis Gracilis 30-60 part.

Preferred: 20 parts of Herba Strigae masuriae, 27 parts of Herba Pteridis multifidaes, 6 parts of Herba Euphrasiae Regeliis, 12 parts of Herba Plantaginis, 9 parts of Herba Hippuridis Vulgaris, 7 parts of Folium Mahoniae, 55 parts of Rhizoma Nupharis Bornetiis, 7 parts of Radix Rubiae, 20 parts of Folium et Ramulus Callicarpae nudiflorae, 45 parts of Herba Amitostigmatis Graciliss.

Preparation method is made decoction by above-mentioned Chinese medicine decocting.

In side: Herba Strigae masuriae heat clearing away eliminating dampness by diuresis diuresis; The removing toxic substances of Herba Pteridis multifidae clearing away heat and promoting diuresis; The relieving restlessness of Herba Euphrasiae Regelii clearing away heat-damp and promoting diuresis; Herba Plantaginis clearing away heat and promoting diuresis, improving eyesight are eliminated the phlegm; Herba Hippuridis Vulgaris clearing away heat and cooling blood, the nutrient solution of promoting the production of body fluid; Folium Mahoniae heat clearing away tonify deficiency, relieving cough and resolving phlegm; Rhizoma Nupharis Bornetii nourishing YIN and clearing away heat; Radix Rubiae hemostasis promoting the circulation of blood, dysmenorrhea are active; Folium et Ramulus Callicarpae nudiflorae hemostasis blood stasis dispelling, analgesic antiphlogistic; The hemostasis of Herba Amitostigmatis Gracilis subduing swelling and detoxicating.

Clinical data

1. the routine patient of physical data 50 is the patient that the court's radiotherapy department is accepted radiotherapy to the chest, through clinical diagnosis, is acute radiation-induced esophagitis.The wherein esophageal carcinoma 24 examples, pulmonary carcinoma 26 examples, male 28 examples, female's 22 examples, 58.5 years old mean age, radiotherapy accumulated dose 58～65Gy, length of esophagus 5～15cm in irradiation field.

2. diagnostic criteria (1) has breast tumor radiotherapy history or is carrying out radiotherapy.(2) clinical manifestation: mediastinal tumor, the non-esophagus disease such as pulmonary carcinoma occurs in Patients During Radiotherapy that with primary disease, without the retrosternal pain of direct relation, feed burn feeling, swallows discomfort, there is feed pain in severe patient, thereby fears feed.In radiotherapy in esophageal carcinoma patients, except occurring above-mentioned symptom, feed difficulty obviously increases the weight of before treating.Have a medical check-up general without obvious sign.(3) esophagogram shows that mucosa is disorderly, blocks and increases the weight of, and tube chamber is less.The visible exposure Esophageal Mucosa of endoscopy is congested, edema, and even pseudomembrane forms.

3. all patients of Therapeutic Method take Chinese medicine preparation of the present invention, take Herba Strigae masuriae 20g, Herba Pteridis multifidae 27g, Herba Euphrasiae Regelii 6g, Herba Plantaginis 12g, Herba Hippuridis Vulgaris 9g, Folium Mahoniae 7g, Rhizoma Nupharis Bornetii 55g, Radix Rubiae 7g, Folium et Ramulus Callicarpae nudiflorae 20g, Herba Amitostigmatis Gracilis 45g, decocting becomes 3 bags of 600ml medicinal liquid subpackages, each 1 bag, the above-mentioned medicinal liquid of slowly swallowing for 3 times every day, every 8h takes 1 time, and 10～15min slowly swallows at every turn, medicinal liquid is fully contacted with impaired mucosa top layer, directly act on focus.

4. criterion of therapeutical effect is effective: swallow pain and dysphagia disappears substantially; Take a turn for the better: swallow pain and (or) dysphagia obviously alleviates; Invalid: swallowing pain and dysphagia has and alleviate or constant.

5. therapeutic effect is originally organized 50 routine patients, treats continuously observe the curative effect after 7 days, effective 38 examples (76.0%), and effective 11 examples (22.0%), invalid 1 example (2.0%), total effective rate is 98%;

The specific embodiment

Embodiment mono-: take Herba Strigae masuriae 20g, Herba Pteridis multifidae 27g, Herba Euphrasiae Regelii 6g, Herba Plantaginis 12g, Herba Hippuridis Vulgaris 9g, Folium Mahoniae 7g, Rhizoma Nupharis Bornetii 55g, Radix Rubiae 7g, Folium et Ramulus Callicarpae nudiflorae 20g, Herba Amitostigmatis Gracilis 45g, above-mentioned Chinese medicine decocting is become to decoction.

Embodiment bis-: take Herba Strigae masuriae 25g, Herba Pteridis multifidae 25g, Herba Euphrasiae Regelii 9g, Herba Plantaginis 9g, Herba Hippuridis Vulgaris 12g, Folium Mahoniae 6g, Rhizoma Nupharis Bornetii 60g, Radix Rubiae 6g, Folium et Ramulus Callicarpae nudiflorae 25g, Herba Amitostigmatis Gracilis 30g, above-mentioned Chinese medicine decocting is become to decoction.

Embodiment tri-: take Herba Strigae masuriae 15g, Herba Pteridis multifidae 30g, Herba Euphrasiae Regelii 3g, Herba Plantaginis 15g, Herba Hippuridis Vulgaris 6g, Folium Mahoniae 9g, Rhizoma Nupharis Bornetii 50g, Radix Rubiae 9g, Folium et Ramulus Callicarpae nudiflorae 15g, Herba Amitostigmatis Gracilis 60g, above-mentioned Chinese medicine decocting is become to decoction.

Claims

1. treat a Chinese medicine preparation for acute radiation-induced esophagitis, it is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: Herba Strigae masuriae 15-25 part, Herba Pteridis multifidae 25-30 part, Herba Euphrasiae Regelii 3-9 part, Herba Plantaginis 9-15 part, Herba Hippuridis Vulgaris 6-12 part, Folium Mahoniae 6-9 part, Rhizoma Nupharis Bornetii 50-60 part, Radix Rubiae 6-9 part, Folium et Ramulus Callicarpae nudiflorae 15-25 part, Herba Amitostigmatis Gracilis 30-60 part.

2. a kind of Chinese medicine preparation for the treatment of acute radiation-induced esophagitis according to claim 1, is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: 20 parts of Herba Strigae masuriae, 27 parts of Herba Pteridis multifidaes, 6 parts of Herba Euphrasiae Regeliis, 12 parts of Herba Plantaginis, 9 parts of Herba Hippuridis Vulgaris, 7 parts of Folium Mahoniae, 55 parts of Rhizoma Nupharis Bornetiis, 7 parts of Radix Rubiae, 20 parts of Folium et Ramulus Callicarpae nudiflorae, 45 parts of Herba Amitostigmatis Graciliss.