CN103638251B - A kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis - Google Patents
A kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis Download PDFInfo
- Publication number
- CN103638251B CN103638251B CN201310723806.9A CN201310723806A CN103638251B CN 103638251 B CN103638251 B CN 103638251B CN 201310723806 A CN201310723806 A CN 201310723806A CN 103638251 B CN103638251 B CN 103638251B
- Authority
- CN
- China
- Prior art keywords
- radix
- herba
- chinese medicine
- medicine composition
- radiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 23
- 230000005855 radiation Effects 0.000 title claims abstract description 14
- 239000000203 mixture Substances 0.000 title claims abstract description 11
- 206010030216 Oesophagitis Diseases 0.000 title claims abstract description 10
- 230000001154 acute effect Effects 0.000 title claims abstract description 10
- 208000006881 esophagitis Diseases 0.000 title claims abstract description 10
- 241001604597 Pyrestini Species 0.000 claims abstract description 10
- 208000002193 Pain Diseases 0.000 abstract description 10
- 231100000614 poison Toxicity 0.000 abstract description 7
- 206010048899 Radiation oesophagitis Diseases 0.000 abstract description 6
- 230000001737 promoting effect Effects 0.000 abstract description 6
- 208000024891 symptom Diseases 0.000 abstract description 6
- 210000001124 body fluid Anatomy 0.000 abstract description 4
- 239000010839 body fluid Substances 0.000 abstract description 4
- 239000003440 toxic substance Substances 0.000 abstract description 4
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 239000002574 poison Substances 0.000 abstract description 3
- 208000027418 Wounds and injury Diseases 0.000 abstract description 2
- 208000014674 injury Diseases 0.000 abstract description 2
- 230000003439 radiotherapeutic effect Effects 0.000 abstract description 2
- 239000003053 toxin Substances 0.000 abstract description 2
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 238000001959 radiotherapy Methods 0.000 description 6
- 208000019505 Deglutition disease Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 201000000349 mediastinal cancer Diseases 0.000 description 3
- 210000004877 mucosa Anatomy 0.000 description 3
- 208000018280 neoplasm of mediastinum Diseases 0.000 description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 210000003238 esophagus Anatomy 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 208000017897 Carcinoma of esophagus Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 241001269238 Data Species 0.000 description 1
- 206010016275 Fear Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 241000167880 Hirundinidae Species 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 238000001839 endoscopy Methods 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 201000005619 esophageal carcinoma Diseases 0.000 description 1
- 208000028299 esophageal disease Diseases 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 231100000567 intoxicating Toxicity 0.000 description 1
- 230000002673 intoxicating effect Effects 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 210000001562 sternum Anatomy 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis.The traditional Chinese medical science is thought, lonizing radiation belong to the heresy of fire-toxin, easy injury-gas consumption.After combination with radiotherapeutic caused radiation esophagitis swallow the symptoms such as pain, meet the feature of " burning hot evil poison ".The present invention selects to have that heat-clearing and toxic substances removing, YIN nourishing and the production of body fluid promoting, damp eliminating are active, the Chinese medicine Radix Vignae yunnanensis of detumescence, Fructus Caraganae Microphyllae, Herba Agerati Conyzoidis, Radix Potentillae sericophyllae, Radix Antiotrematis dunniani, Herba Scleriae Terrestris, Cortex erythrinae, Herba speranskiae cantonensis, Herba Passiflorae Wilsonii, Radix securidacae, decocting becomes decoction, through clinical trial, total effective rate reaches 97.1%, obviously be better than 77.1% of matched group, evident in efficacy.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis.
Background technology
Radiation esophagitis (radiationesophagitis, RE) be the dose-limiting reaction that chest and head-neck malignant tumor patient occur when accepting radiotherapy, be there is hyperemia with normal esophageal mucosa in irradiation field, edema, erosion or inflammatory exudation sexually revise even ulcer, can concurrent infection be a kind of disease of feature on its basis.Usually show as dysphagia companion pain clinically, foreign body sensation after breastbone, burn feeling and feed postemphasis; doctor trained in Western medicine prevents and treats radiation esophagitis mainly based on anti symptom treatment such as pain relieving spasmolytic, anti-inflammation, protection gastrointestinal mucosals; although effectively partial symptoms can be alleviated; but its side effect also clearly, bounce after can increasing the weight of or bring out concurrent infection, digestive tract hemorrhage, drug withdrawal to the suppression of immunologic function.Radiotherapy is interrupted and treatment time prolongation can reduce therapeutic effect again.Applicant proves through clinical trial for many years, Chinese medicine prevention acute radiation-induced esophagitis not only curative effect certainly, to have no side effect but also cheap, for raising body toleration, reduce the incidence rate of radiation esophagitis, there is significant curative effect alleviating pain aspect.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis.Acute radiation-induced esophagitis belongs to motherland's medical science " dysphagic ", " regurgitation " category.The traditional Chinese medical science is thought, lonizing radiation belong to the heresy of fire-toxin, easy injury-gas consumption.After combination with radiotherapeutic caused radiation esophagitis swallow the symptoms such as pain, meet the feature of " burning hot evil poison ".Therefore, it is generally acknowledged that its pathogenesis is the burning hot poison heresy of lonizing radiation generation, damage human body, invade internal organs, intoxicating heat is flourishing, stomach-QI being unable to descend normally, body fluid-deficiency causing blood-dryness, so that esophagus is dry and astringent, and food difficulty enters.Be subject to exopathogen, phlegm resistance, indigestion because of sudden and violent, transformation and transportation of the spleen and stomach is lacked of proper care, so that phlegm retention superinverse simultaneously.Pyretic toxicity is for a long time strongly fragrant, can occur blood stasis symptom again.The one side of its existing domination of pathogen, i.e. solidifying, the blood stasis of depressed, expectorant, have again the one side of deficiency in origin, i.e. depletion of body fluid causing lack of blood, pathologic feature is deficiency in origin and excess in superficiality.Treat, detumescence active with heat-clearing and toxic substances removing, YIN nourishing and the production of body fluid promoting, damp eliminating for principle.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treatment acute radiation-induced esophagitis is made up of the Chinese medicine of following weight portion: Radix Vignae yunnanensis 9-15 part, Fructus Caraganae Microphyllae 5-10 part, Herba Agerati Conyzoidis 15-25 part, Radix Potentillae sericophyllae 30-60 part, Radix Antiotrematis dunniani 9-15 part, Herba Scleriae Terrestris 15-25 part, Cortex erythrinae 6-12 part, Herba speranskiae cantonensis 40-50 part, Herba Passiflorae Wilsonii 9-15 part, Radix securidacae 3-6 part.
Preferred: Radix Vignae yunnanensis 12g, Fructus Caraganae Microphyllae 7g, Herba Agerati Conyzoidis 20g, Radix Potentillae sericophyllae 45g, Radix Antiotrematis dunniani 12g, Herba Scleriae Terrestris 20g, Cortex erythrinae 9g, Herba speranskiae cantonensis 45g, Herba Passiflorae Wilsonii 12g, Radix securidacae 5g.
Above-mentioned Chinese medicine decocting is made decoction by preparation method.
Fang Zhong: Radix Vignae yunnanensis, Fructus Caraganae Microphyllae, Herba Agerati Conyzoidis heat-clearing and toxic substances removing, detumescence sore-throat relieving; Radix Potentillae sericophyllae promoting the production of body fluid to quench thirst, nourishing YIN, clearind deficient heat; Radix Antiotrematis dunniani yin nourishing tonify deficiency, heat-clearing and toxic substances removing; Herba Scleriae Terrestris, Cortex erythrinae, Herba speranskiae cantonensis are except rheumatism, the meridian dredging; Herba Passiflorae Wilsonii blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons and activating QI and blood in the collateral; Radix securidacae promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, clearing away heat and promoting diuresis.
Clinical data
1. physical data MethodsThe cases enrolled 70 example, is divided into two groups at random.Treatment group 35 example, man 25 example, female 10 example, 61 years old mean age; Pulmonary carcinoma 28 example, mediastinal tumor 7 example, wherein row operator 9 is routine.Matched group 35 example, man 23 example, female 12 example, 59 years old mean age; 29 Cases of Lung Cancer, mediastinal tumor 6 example, row operator 11 example.Two groups of clinical datas irradiate no significant difference (P > 0.05) on total length at age, sex, irradiation accumulated dose and esophagus.。
2。Diagnostic criteria (1) has breast tumor radiotherapy history or is carrying out radiotherapy.(2) clinical manifestation: mediastinal tumor, the non-esophagus disease such as pulmonary carcinoma occurs and the retrosternal pain of primary disease without direct relation in Patients During Radiotherapy, and feed burn feeling, swallows discomfort, and feed pain appears in severe patient, thus fears feed.In radiotherapy in esophageal carcinoma patients except there is above-mentioned symptom, eating difficulties obviously increases the weight of before comparatively treating.Have a medical check-up general without obvious sign.(3) esophagogram shows that mucosa is disorderly, and block and increase the weight of, tube chamber is less.The visible exposure Esophageal Mucosa of endoscopy is congested, edema, and even pseudomembrane is formed.
3. Therapeutic Method treatment group takes Chinese medicine preparation of the present invention, takes Radix Vignae yunnanensis 12g, Fructus Caraganae Microphyllae 7g, Herba Agerati Conyzoidis 20g, Radix Potentillae sericophyllae 45g, Radix Antiotrematis dunniani 12g, Herba Scleriae Terrestris 20g, Cortex erythrinae 9g, Herba speranskiae cantonensis 45g, Herba Passiflorae Wilsonii 12g, Radix securidacae 5g.Decocting makes decoction, 10 times/d, 20mL/ time, and after taking medicine, 5min prohibits drinking-water.The gargarism that during matched group radiation treatment, conventional application normal saline, sodium bicarbonate, lignocaine are made into is gargled or buccal to patient.
4. criterion of therapeutical effect is effective: swallow pain and dysphagia disappears substantially; Take a turn for the better: swallow pain and (or) dysphagia obviously alleviates; Invalid: swallowing pain and dysphagia has and to alleviate or constant.
5. therapeutic effect two groups treats observe the curative effect after 10 days continuously.In treatment group 35 example, effective 23 examples (65.7%), effective 11 examples (31.4%), invalid 1 example (2.9%), total effective rate is 97.1%; In matched group 35 example, effective 11 examples (31.4%), effective 16 examples (45.7%), invalid 8 examples (22.9%), total effective rate is 77.1%.Two groups of total effective rate comparing differences have significant (P < 0.05), and treatment group therapeutic effect is obviously better than matched group.
Detailed description of the invention
Embodiment one: take Radix Vignae yunnanensis 12g, Fructus Caraganae Microphyllae 7g, Herba Agerati Conyzoidis 20g, Radix Potentillae sericophyllae 45g, Radix Antiotrematis dunniani 12g, Herba Scleriae Terrestris 20g, Cortex erythrinae 9g, Herba speranskiae cantonensis 45g, Herba Passiflorae Wilsonii 12g, Radix securidacae 5g, takes and above-mentioned Chinese medicine decocting is become decoction.
Embodiment two takes Radix Vignae yunnanensis 15g, Fructus Caraganae Microphyllae 10g, Herba Agerati Conyzoidis 25g, Radix Potentillae sericophyllae 60g, Radix Antiotrematis dunniani 9g, Herba Scleriae Terrestris 15g, Cortex erythrinae 12g, Herba speranskiae cantonensis 40g, Herba Passiflorae Wilsonii 9g, Radix securidacae 3g, takes and above-mentioned Chinese medicine decocting is become decoction.
Embodiment three: take Radix Vignae yunnanensis 9g, Fructus Caraganae Microphyllae 5g, Herba Agerati Conyzoidis 15g, Radix Potentillae sericophyllae 30g, Radix Antiotrematis dunniani 15g, Herba Scleriae Terrestris 25g, Cortex erythrinae 6g, Herba speranskiae cantonensis 50g, Herba Passiflorae Wilsonii 15g, Radix securidacae 6g, takes and above-mentioned Chinese medicine decocting is become decoction.
Claims (2)
1. treat a Chinese medicine composition for acute radiation-induced esophagitis, it is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Radix Vignae yunnanensis 9-15 part, Fructus Caraganae Microphyllae 5-10 part, Herba Agerati Conyzoidis 15-25 part, Radix Potentillae sericophyllae 30-60 part, Radix Antiotrematis dunniani 9-15 part, Herba Scleriae Terrestris 15-25 part, Cortex erythrinae 6-12 part, Herba speranskiae cantonensis 40-50 part, Herba Passiflorae Wilsonii 9-15 part, Radix securidacae 3-6 part.
2. a kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis according to claim 1, is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight: Radix Vignae yunnanensis 12g, Fructus Caraganae Microphyllae 7g, Herba Agerati Conyzoidis 20g, Radix Potentillae sericophyllae 45g, Radix Antiotrematis dunniani 12g, Herba Scleriae Terrestris 20g, Cortex erythrinae 9g, Herba speranskiae cantonensis 45g, Herba Passiflorae Wilsonii 12g, Radix securidacae 5g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310723806.9A CN103638251B (en) | 2013-12-15 | 2013-12-15 | A kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310723806.9A CN103638251B (en) | 2013-12-15 | 2013-12-15 | A kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103638251A CN103638251A (en) | 2014-03-19 |
| CN103638251B true CN103638251B (en) | 2016-02-17 |
Family
ID=50243623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310723806.9A Active CN103638251B (en) | 2013-12-15 | 2013-12-15 | A kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103638251B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104971237A (en) * | 2014-04-09 | 2015-10-14 | 张梅 | Traditional Chinese medicine combined preparation for treating radiation esophagitis |
| CN105343553A (en) * | 2015-12-02 | 2016-02-24 | 王海莲 | Traditional Chinese medicine oral buccal tablet for treating radiation esophagitis, and preparation method of traditional Chinese medicine oral buccal tablet |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1586585A (en) * | 2004-07-16 | 2005-03-02 | 福州海王金象中药制药有限公司 | Shenghong heat clearing capsule |
| CN101053593A (en) * | 2006-04-14 | 2007-10-17 | 徐燕和 | Shenghong heat-clearing granule and its preparation method |
-
2013
- 2013-12-15 CN CN201310723806.9A patent/CN103638251B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1586585A (en) * | 2004-07-16 | 2005-03-02 | 福州海王金象中药制药有限公司 | Shenghong heat clearing capsule |
| CN101053593A (en) * | 2006-04-14 | 2007-10-17 | 徐燕和 | Shenghong heat-clearing granule and its preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103638251A (en) | 2014-03-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101327313B (en) | Oral medication for treating epigastric pain | |
| CN103638320B (en) | A kind of Chinese medicine preparation for the treatment of acute radiation-induced esophagitis | |
| CN103638251B (en) | A kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis | |
| CN106038965A (en) | Traditional Chinese medicinal composition for treating throat diseases | |
| CN104623408A (en) | Traditional Chinese medicine preparation for treating toxic diffuse goiter | |
| CN104383244A (en) | Traditional Chinese medicine composition for treating esophagus cancer and preparation method of traditional Chinese medicine composition | |
| CN104857454B (en) | A kind of traditional Chinese herbal decoction for treating Severe Acute Pancreatitis SAP | |
| CN103690789B (en) | A kind of Chinese medicine preparation for the treatment of radioactive stomatitis | |
| CN103877384B (en) | A kind of Chinese medicine preparation and preparation method who treats the carcinoma of the rectum | |
| CN104523927A (en) | Traditional Chinese medicine composition for treating phlegm stagnant type esophageal cancer and application thereof | |
| CN103656319B (en) | A kind of external traditional Chinese medicinal application for the treatment of acute radiation-induced esophagitis | |
| CN103520341A (en) | Traditional Chinese medicine prescription used for treating esophageal cancer | |
| CN104971237A (en) | Traditional Chinese medicine combined preparation for treating radiation esophagitis | |
| CN103585607B (en) | Traditional Chinese medicine for treating facial paralysis | |
| CN1457805A (en) | Chinese medicine preparation for curing eophagus cancer | |
| CN105770657A (en) | Traditional Chinese medicinal preparation for treating enterobiasis and preparation method thereof | |
| CN104491504A (en) | Traditional Chinese medicine preparation for treating pleural effusion | |
| CN104906349A (en) | Traditional Chinese medicine oral liquid for treating gastric ulcer and preparation method thereof | |
| CN103933390B (en) | Traditional Chinese medicinal preparation for treating breast cystic hyperplasia | |
| CN104740543A (en) | Drug for treating flat warts and preparation method for drug | |
| CN103070998B (en) | Externally-applied plaster for curing pain of rheumatic joints | |
| CN115192673A (en) | Traditional Chinese medicine composition for treating sarcoidosis and preparation method thereof | |
| CN109419968A (en) | A kind of oral traditional Chinese medicine composition for treating the cancer of the esophagus | |
| CN109364203A (en) | The oral drugs for treating gastric cancer | |
| CN105770572A (en) | Traditional Chinese medicinal preparation for treating pityriasis rosea |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170510 Address after: 226100, No. 588, Jinyang Road, Yue Yue town, Haimen, Jiangsu, Nantong Patentee after: Haimen Yue Yue Textile Co., Ltd. Address before: 276400 Linyi health center, Yishui, Shandong, China, Yishui Central Hospital, No. 17, Patentee before: Guo Shuning |