CN103638251B - A kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis - Google Patents

A kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis Download PDF

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CN103638251B
CN103638251B CN201310723806.9A CN201310723806A CN103638251B CN 103638251 B CN103638251 B CN 103638251B CN 201310723806 A CN201310723806 A CN 201310723806A CN 103638251 B CN103638251 B CN 103638251B
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herba
chinese medicine
medicine composition
radiation
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CN103638251A (en
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郭淑宁
冯庆亮
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Haimen Yue Yue Textile Co Ltd
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Abstract

The invention discloses a kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis.The traditional Chinese medical science is thought, lonizing radiation belong to the heresy of fire-toxin, easy injury-gas consumption.After combination with radiotherapeutic caused radiation esophagitis swallow the symptoms such as pain, meet the feature of " burning hot evil poison ".The present invention selects to have that heat-clearing and toxic substances removing, YIN nourishing and the production of body fluid promoting, damp eliminating are active, the Chinese medicine Radix Vignae yunnanensis of detumescence, Fructus Caraganae Microphyllae, Herba Agerati Conyzoidis, Radix Potentillae sericophyllae, Radix Antiotrematis dunniani, Herba Scleriae Terrestris, Cortex erythrinae, Herba speranskiae cantonensis, Herba Passiflorae Wilsonii, Radix securidacae, decocting becomes decoction, through clinical trial, total effective rate reaches 97.1%, obviously be better than 77.1% of matched group, evident in efficacy.

Description

A kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis.
Background technology
Radiation esophagitis (radiationesophagitis, RE) be the dose-limiting reaction that chest and head-neck malignant tumor patient occur when accepting radiotherapy, be there is hyperemia with normal esophageal mucosa in irradiation field, edema, erosion or inflammatory exudation sexually revise even ulcer, can concurrent infection be a kind of disease of feature on its basis.Usually show as dysphagia companion pain clinically, foreign body sensation after breastbone, burn feeling and feed postemphasis; doctor trained in Western medicine prevents and treats radiation esophagitis mainly based on anti symptom treatment such as pain relieving spasmolytic, anti-inflammation, protection gastrointestinal mucosals; although effectively partial symptoms can be alleviated; but its side effect also clearly, bounce after can increasing the weight of or bring out concurrent infection, digestive tract hemorrhage, drug withdrawal to the suppression of immunologic function.Radiotherapy is interrupted and treatment time prolongation can reduce therapeutic effect again.Applicant proves through clinical trial for many years, Chinese medicine prevention acute radiation-induced esophagitis not only curative effect certainly, to have no side effect but also cheap, for raising body toleration, reduce the incidence rate of radiation esophagitis, there is significant curative effect alleviating pain aspect.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis.Acute radiation-induced esophagitis belongs to motherland's medical science " dysphagic ", " regurgitation " category.The traditional Chinese medical science is thought, lonizing radiation belong to the heresy of fire-toxin, easy injury-gas consumption.After combination with radiotherapeutic caused radiation esophagitis swallow the symptoms such as pain, meet the feature of " burning hot evil poison ".Therefore, it is generally acknowledged that its pathogenesis is the burning hot poison heresy of lonizing radiation generation, damage human body, invade internal organs, intoxicating heat is flourishing, stomach-QI being unable to descend normally, body fluid-deficiency causing blood-dryness, so that esophagus is dry and astringent, and food difficulty enters.Be subject to exopathogen, phlegm resistance, indigestion because of sudden and violent, transformation and transportation of the spleen and stomach is lacked of proper care, so that phlegm retention superinverse simultaneously.Pyretic toxicity is for a long time strongly fragrant, can occur blood stasis symptom again.The one side of its existing domination of pathogen, i.e. solidifying, the blood stasis of depressed, expectorant, have again the one side of deficiency in origin, i.e. depletion of body fluid causing lack of blood, pathologic feature is deficiency in origin and excess in superficiality.Treat, detumescence active with heat-clearing and toxic substances removing, YIN nourishing and the production of body fluid promoting, damp eliminating for principle.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treatment acute radiation-induced esophagitis is made up of the Chinese medicine of following weight portion: Radix Vignae yunnanensis 9-15 part, Fructus Caraganae Microphyllae 5-10 part, Herba Agerati Conyzoidis 15-25 part, Radix Potentillae sericophyllae 30-60 part, Radix Antiotrematis dunniani 9-15 part, Herba Scleriae Terrestris 15-25 part, Cortex erythrinae 6-12 part, Herba speranskiae cantonensis 40-50 part, Herba Passiflorae Wilsonii 9-15 part, Radix securidacae 3-6 part.
Preferred: Radix Vignae yunnanensis 12g, Fructus Caraganae Microphyllae 7g, Herba Agerati Conyzoidis 20g, Radix Potentillae sericophyllae 45g, Radix Antiotrematis dunniani 12g, Herba Scleriae Terrestris 20g, Cortex erythrinae 9g, Herba speranskiae cantonensis 45g, Herba Passiflorae Wilsonii 12g, Radix securidacae 5g.
Above-mentioned Chinese medicine decocting is made decoction by preparation method.
Fang Zhong: Radix Vignae yunnanensis, Fructus Caraganae Microphyllae, Herba Agerati Conyzoidis heat-clearing and toxic substances removing, detumescence sore-throat relieving; Radix Potentillae sericophyllae promoting the production of body fluid to quench thirst, nourishing YIN, clearind deficient heat; Radix Antiotrematis dunniani yin nourishing tonify deficiency, heat-clearing and toxic substances removing; Herba Scleriae Terrestris, Cortex erythrinae, Herba speranskiae cantonensis are except rheumatism, the meridian dredging; Herba Passiflorae Wilsonii blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons and activating QI and blood in the collateral; Radix securidacae promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, clearing away heat and promoting diuresis.
Clinical data
1. physical data MethodsThe cases enrolled 70 example, is divided into two groups at random.Treatment group 35 example, man 25 example, female 10 example, 61 years old mean age; Pulmonary carcinoma 28 example, mediastinal tumor 7 example, wherein row operator 9 is routine.Matched group 35 example, man 23 example, female 12 example, 59 years old mean age; 29 Cases of Lung Cancer, mediastinal tumor 6 example, row operator 11 example.Two groups of clinical datas irradiate no significant difference (P > 0.05) on total length at age, sex, irradiation accumulated dose and esophagus.。
2。Diagnostic criteria (1) has breast tumor radiotherapy history or is carrying out radiotherapy.(2) clinical manifestation: mediastinal tumor, the non-esophagus disease such as pulmonary carcinoma occurs and the retrosternal pain of primary disease without direct relation in Patients During Radiotherapy, and feed burn feeling, swallows discomfort, and feed pain appears in severe patient, thus fears feed.In radiotherapy in esophageal carcinoma patients except there is above-mentioned symptom, eating difficulties obviously increases the weight of before comparatively treating.Have a medical check-up general without obvious sign.(3) esophagogram shows that mucosa is disorderly, and block and increase the weight of, tube chamber is less.The visible exposure Esophageal Mucosa of endoscopy is congested, edema, and even pseudomembrane is formed.
3. Therapeutic Method treatment group takes Chinese medicine preparation of the present invention, takes Radix Vignae yunnanensis 12g, Fructus Caraganae Microphyllae 7g, Herba Agerati Conyzoidis 20g, Radix Potentillae sericophyllae 45g, Radix Antiotrematis dunniani 12g, Herba Scleriae Terrestris 20g, Cortex erythrinae 9g, Herba speranskiae cantonensis 45g, Herba Passiflorae Wilsonii 12g, Radix securidacae 5g.Decocting makes decoction, 10 times/d, 20mL/ time, and after taking medicine, 5min prohibits drinking-water.The gargarism that during matched group radiation treatment, conventional application normal saline, sodium bicarbonate, lignocaine are made into is gargled or buccal to patient.
4. criterion of therapeutical effect is effective: swallow pain and dysphagia disappears substantially; Take a turn for the better: swallow pain and (or) dysphagia obviously alleviates; Invalid: swallowing pain and dysphagia has and to alleviate or constant.
5. therapeutic effect two groups treats observe the curative effect after 10 days continuously.In treatment group 35 example, effective 23 examples (65.7%), effective 11 examples (31.4%), invalid 1 example (2.9%), total effective rate is 97.1%; In matched group 35 example, effective 11 examples (31.4%), effective 16 examples (45.7%), invalid 8 examples (22.9%), total effective rate is 77.1%.Two groups of total effective rate comparing differences have significant (P < 0.05), and treatment group therapeutic effect is obviously better than matched group.
Detailed description of the invention
Embodiment one: take Radix Vignae yunnanensis 12g, Fructus Caraganae Microphyllae 7g, Herba Agerati Conyzoidis 20g, Radix Potentillae sericophyllae 45g, Radix Antiotrematis dunniani 12g, Herba Scleriae Terrestris 20g, Cortex erythrinae 9g, Herba speranskiae cantonensis 45g, Herba Passiflorae Wilsonii 12g, Radix securidacae 5g, takes and above-mentioned Chinese medicine decocting is become decoction.
Embodiment two takes Radix Vignae yunnanensis 15g, Fructus Caraganae Microphyllae 10g, Herba Agerati Conyzoidis 25g, Radix Potentillae sericophyllae 60g, Radix Antiotrematis dunniani 9g, Herba Scleriae Terrestris 15g, Cortex erythrinae 12g, Herba speranskiae cantonensis 40g, Herba Passiflorae Wilsonii 9g, Radix securidacae 3g, takes and above-mentioned Chinese medicine decocting is become decoction.
Embodiment three: take Radix Vignae yunnanensis 9g, Fructus Caraganae Microphyllae 5g, Herba Agerati Conyzoidis 15g, Radix Potentillae sericophyllae 30g, Radix Antiotrematis dunniani 15g, Herba Scleriae Terrestris 25g, Cortex erythrinae 6g, Herba speranskiae cantonensis 50g, Herba Passiflorae Wilsonii 15g, Radix securidacae 6g, takes and above-mentioned Chinese medicine decocting is become decoction.

Claims (2)

1. treat a Chinese medicine composition for acute radiation-induced esophagitis, it is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Radix Vignae yunnanensis 9-15 part, Fructus Caraganae Microphyllae 5-10 part, Herba Agerati Conyzoidis 15-25 part, Radix Potentillae sericophyllae 30-60 part, Radix Antiotrematis dunniani 9-15 part, Herba Scleriae Terrestris 15-25 part, Cortex erythrinae 6-12 part, Herba speranskiae cantonensis 40-50 part, Herba Passiflorae Wilsonii 9-15 part, Radix securidacae 3-6 part.
2. a kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis according to claim 1, is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight: Radix Vignae yunnanensis 12g, Fructus Caraganae Microphyllae 7g, Herba Agerati Conyzoidis 20g, Radix Potentillae sericophyllae 45g, Radix Antiotrematis dunniani 12g, Herba Scleriae Terrestris 20g, Cortex erythrinae 9g, Herba speranskiae cantonensis 45g, Herba Passiflorae Wilsonii 12g, Radix securidacae 5g.
CN201310723806.9A 2013-12-15 2013-12-15 A kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis Active CN103638251B (en)

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CN104971237A (en) * 2014-04-09 2015-10-14 张梅 Traditional Chinese medicine combined preparation for treating radiation esophagitis
CN105343553A (en) * 2015-12-02 2016-02-24 王海莲 Traditional Chinese medicine oral buccal tablet for treating radiation esophagitis, and preparation method of traditional Chinese medicine oral buccal tablet

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1586585A (en) * 2004-07-16 2005-03-02 福州海王金象中药制药有限公司 Shenghong heat clearing capsule
CN101053593A (en) * 2006-04-14 2007-10-17 徐燕和 Shenghong heat-clearing granule and its preparation method

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1586585A (en) * 2004-07-16 2005-03-02 福州海王金象中药制药有限公司 Shenghong heat clearing capsule
CN101053593A (en) * 2006-04-14 2007-10-17 徐燕和 Shenghong heat-clearing granule and its preparation method

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Effective date of registration: 20170510

Address after: 226100, No. 588, Jinyang Road, Yue Yue town, Haimen, Jiangsu, Nantong

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Patentee before: Guo Shuning