CN104623408A - Traditional Chinese medicine preparation for treating toxic diffuse goiter - Google Patents
Traditional Chinese medicine preparation for treating toxic diffuse goiter Download PDFInfo
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- CN104623408A CN104623408A CN201410858090.8A CN201410858090A CN104623408A CN 104623408 A CN104623408 A CN 104623408A CN 201410858090 A CN201410858090 A CN 201410858090A CN 104623408 A CN104623408 A CN 104623408A
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating toxic diffuse goiter. The preparation is prepared from the following medicinal raw materials by weight: 20-30g of radix rehmanniae recen, 10-20g of radix paeoniae alba, 10-20g of asparagus fern, 10-20g of radix ophiopogonis, 10-20g of selfheal, 8-15g of turtle shell, 8-15g of oyster, 8-15g of nacre mother of pearl, 8-15g of bulbus fritillariae cirrhosae, 8-12g of salviae miltiorrhizae, 8-12g of coix seed, 8-12g of euphorbia helioscopia and 8-12g of edible tulip. The medicinal materials are well combined to achieve the effects of clearing heat, cooling blood, nourishing yin, promoting generation of body fluid, nourishing yin for suppressing hyperactive yang, softening hardness to dissipate stagnation, clearing damp, promoting diuresis and removing toxicity, and is worthy of clinical popularization and application.
Description
Technical field
The invention belongs to the field of Chinese medicines, specifically a kind of Chinese medicine preparation can treating graves.
Background technology
Graves is a kind of autoimmune disease, and its clinical manifestation is not limited to thyroid, but a kind of syndrome of multisystem, be cause hyperthyroidism, the hyperthyroidism great majority said clinically refer to primary disease, but the two is not equal to.The main cause of disease comprises: hypermetabolism disease group diffuse goiter, eye is levied, skin lesion and thyroid acropachy.Because most of patients has hypermetabolism disease and thyromegaly simultaneously, therefore be called graves, the wellability endocrine exophthalmos that shows as beyond thyroid can individualism and without hypermetabolism disease.Primary disease is more common in women, M-F 1: 4-1: 6, and each age level all can be fallen ill, and the most common with 20-40 year, a lot of disease is slow.When showing typical case, the performance that hypermetabolism syndrome, goiter and eye levy three aspects is all comparatively obvious.
Current doctor trained in Western medicine mainly adopts antithyroid drug, radioactive iodine131 itherapy and excision thyroid to treat, but Drug therapy has side effect, and the postoperative some patients that makes produces multiple post-operative complication, patient is therefore very painful, for removing the misery of the mind & body of patient, according to the principle of tcm syndrome differentiation and treatment, treating both the principal and the secondary aspects of a disease at the same time, we provide a kind of Chinese medicine preparation, be used for the treatment of graves and achieve satisfied effect.
Summary of the invention
Instant invention overcomes the technical deficiency existed in treatment graves at present, provide a kind of hurtless measure, evident in efficacy, cheap, patient compliance is higher, cure after the Chinese medicine preparation that not easily recurs.
The technical solution adopted in the present invention is:
Treat a Chinese medicine preparation for graves, it is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Radix Rehmanniae 20-30 gram, Radix Paeoniae Alba 10-20 gram, Radix Asparagi 10-20 gram, Radix Ophiopogonis 10-20 gram, Spica Prunellae 10-20 gram, Carapax Trionycis 8-15 gram, Carapax et Plastrum Testudinis 8-15 gram, Concha Ostreae 8-15 gram, Concha Margaritifera 8-15 gram, Bulbus Fritillariae Cirrhosae 8-15 gram, Radix Salviae Miltiorrhizae 8-12 gram, Semen Coicis 8-12 gram, Herba Euphorbiae Helioscopiae 8-12 gram, Pseudobulbus Cremastrae Seu Pleiones 8-12 gram.
As this kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
20 grams, the Radix Rehmanniae, the Radix Paeoniae Alba 10 grams, Radix Asparagi 10 grams, Radix Ophiopogonis 10 grams, Spica Prunellae 10 grams, Carapax Trionycis 8 grams, Carapax et Plastrum Testudinis 8 grams, Concha Ostreae 8 grams, Concha Margaritifera 8 grams, Bulbus Fritillariae Cirrhosae 8 grams, Radix Salviae Miltiorrhizae 8 grams, Semen Coicis 8 grams, Herba Euphorbiae Helioscopiae 8 grams, Pseudobulbus Cremastrae Seu Pleiones 8 grams.
As this kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
25 grams, the Radix Rehmanniae, the Radix Paeoniae Alba 15 grams, Radix Asparagi 15 grams, Radix Ophiopogonis 15 grams, Spica Prunellae 15 grams, Carapax Trionycis 12 grams, Carapax et Plastrum Testudinis 12 grams, Concha Ostreae 12 grams, Concha Margaritifera 12 grams, Bulbus Fritillariae Cirrhosae 12 grams, Radix Salviae Miltiorrhizae 10 grams, Semen Coicis 10 grams, Herba Euphorbiae Helioscopiae 10 grams, Pseudobulbus Cremastrae Seu Pleiones 10 grams.
As this kind of prioritization scheme:
Described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
30 grams, the Radix Rehmanniae, the Radix Paeoniae Alba 20 grams, Radix Asparagi 20 grams, Radix Ophiopogonis 20 grams, Spica Prunellae 20 grams, Carapax Trionycis 15 grams, Carapax et Plastrum Testudinis 15 grams, Concha Ostreae 15 grams, Concha Margaritifera 15 grams, Bulbus Fritillariae Cirrhosae 15 grams, Radix Salviae Miltiorrhizae 12 grams, Semen Coicis 12 grams, Herba Euphorbiae Helioscopiae 12 grams, Pseudobulbus Cremastrae Seu Pleiones 12 grams.
The instructions of taking of Chinese medicine preparation of the present invention is: Carapax Trionycis, Carapax et Plastrum Testudinis, Concha Ostreae, Concha Margaritifera, Bulbus Fritillariae Cirrhosae are mixed with above-mentioned weight proportion, add water 500ml, is decocted first 30 minutes, afterwards residue Chinese medicine is put into warm fire with above-mentioned weight proportion and boils 30 minutes, extracting juice 250ml; Two decoct the 300ml that adds water, and warm fire boils 20 minutes, extracting juice 150ml.Two decoct mixing, sooner or later empty stomach decoction being taken hot.20 doses was 1 course for the treatment of.
The raw material Chinese medicine of above-mentioned Chinese medicine preparation:
The Radix Rehmanniae: sweet in the mouth, hardship, cold in nature; GUIXIN, liver, kidney channel.There is clearing away heat and cooling blood, effect of YIN nourishing and the production of body fluid promoting.
The Radix Paeoniae Alba: bitter in the mouth, acid, cold nature; Return liver, spleen channel.There is the yin fluid astringing that nourishes blood, easing the affected liver to relieve pain, effect of suppressing liver-YANG.
Radix Asparagi: sweet in the mouth, hardship, property Great Cold; Return lung, kidney channel.There is lung heat clearing pathogenic fire reducing, nourshing Yin and drynsessmoistening prescription effect.
Radix Ophiopogonis: sweet in the mouth, micro-hardship, cold nature; Return lung, the heart, stomach warp.There is nourishing YIN and moistening the lung, reinforcing stomach reg fluid, the effect of the relieving restlessness that clears away heart-fire.
Spica Prunellae: acrid in the mouth, hardship, cold in nature; Return liver, gallbladder meridian.There is clearing away liver-fire, Disperse hepatic depression, effect of suppressing the hyperactive liver sun.
Carapax Trionycis: salty in the mouth, cold in nature; Return Liver Channel.There is nourishing YIN for suppressing the hyperactive YANG, effect of hard masses softening and resolving.
Carapax et Plastrum Testudinis: sweet in the mouth, salty, cold in nature; Return kidney, heart channel.There is nourishing YIN for suppressing the hyperactive YANG, replenishing kidney and strengthening bone, the effect of reinforcing the heart of nourishing blood.
Concha Ostreae: salty in the mouth, cold nature; Return liver, kidney channel.There is suppressing the hyperactive liver and subsiding YANG, hard masses softening and resolving, restrain astringent or styptic treatment for spontaneous sweating effect.
Concha Margaritifera: salty in the mouth, cold in nature; Return liver, heart channel.There is suppressing the hyperactive liver and subsiding YANG, effect of liver heat removing and eyesight improving.
Bulbus Fritillariae Cirrhosae: bitter in the mouth, sweet, cold nature; GUIXIN, lung meridian.There is preventing phlegm from forming and stopping coughing, effect of heat clearing away eliminating stagnation.
Radix Salviae Miltiorrhizae: bitter in the mouth, cold nature; GUIXIN, pericardium, Liver Channel.There is blood circulation promoting and blood stasis dispelling, removing heat from blood eliminating carbuncle, effect of nourishing blood to tranquillize the mind.
Semen Coicis: sweet in the mouth, light, cold nature; Return spleen, stomach, lung meridian.There is promoting diuresis to eliminate damp pathogen, invigorating the spleen to arrest diarrhea, damp eliminating eliminating impediment, effect of clearing away heat and discharging pus.
Herba Euphorbiae Helioscopiae: acrid in the mouth, hardship, cold nature; Return lung, small intestinal, large intestine channel.There is inducing diuresis to remove edema, effect of dissipating phlegm and resolving masses.
Pseudobulbus Cremastrae Seu Pleiones: sweet in the mouth, micro-pungent, cold in nature; Return liver, stomach warp.There is heat-clearing and toxic substances removing, effect of eliminating carbuncle eliminating stagnation.
Graves in differential diagnosis in tcm more belongs to deficiency of YIN stagnation of liver-QI, excessive rising of liver-YANG, and employing YANG hyperactivity suppressing is the rule for the treatment of.Modern medicine thinks primary disease system autoimmune disease, but its pathogeny is illustrated not yet completely, one of its feature exists to have in serum to react with parathyroid tissue or the autoantibody of stimulation, this antibody capable stimulates the thyroid of rodent, improve its function and cause the hypertrophy of tissue, but its effect is slow and lasting.Therefore treat primary disease to show according to patient's different symptoms, with clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, fundamentally adjust body, dialectical treatment, applies in a flexible way, and Fang Xianqi is imitated.
In Chinese medicine preparation of the present invention, the Radix Rehmanniae, the Radix Paeoniae Alba can clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, suppressing the hyperactive liver; Radix Asparagi, Radix Ophiopogonis, Spica Prunellae can nourishing YIN and moistening the lung, suppressing the hyperactive liver eliminating stagnation; Carapax Trionycis, Carapax et Plastrum Testudinis, Concha Ostreae, Concha Margaritifera, Bulbus Fritillariae Cirrhosae can nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, reinforcing the heart of nourishing blood, suppressing the hyperactive liver; Radix Salviae Miltiorrhizae, Semen Coicis, Herba Euphorbiae Helioscopiae, Pseudobulbus Cremastrae Seu Pleiones can promoting diuresis to eliminate damp pathogen, heat-clearing and toxic substances removing, removing heat from blood.Full side's compatibility is superior, attacks benefit and executes mutually, treating both the principal and secondary aspects of a disease, has given full play to the advantage that differential diagnosis in tcm treats, be used for the treatment of graves, there is clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, promoting diuresis to eliminate damp pathogen, the merit of heat-clearing and toxic substances removing, clinic promotion and application.
For investigating clinical efficacy and the safety of medicine of the present invention further, we select the routine out-patient of certain hospital 70 to carry out clinical trial, minimum 23 years old of age, maximum 43 years old, average 31 years old; The course of disease is the shortest 3 months, the longest 1 year, average 6 months; Hypermetabolism syndrome patient 30 example, goiter patient 25 example, eye levies patient 15 example.
Criterion of therapeutical effect:
Cure: clinical symptoms, sign disappear, and the symptoms such as goiter, hypermetabolism and nerve excitability disappear completely.
Effective: clinical symptoms, sign obviously alleviate, the symptoms such as goiter, hypermetabolism and nerve excitability obviously alleviate before comparatively treating.
Effective: the symptoms such as slightly the alleviated goiter of clinical symptoms, sign, hypermetabolism and excited property alleviate to some extent.
Invalid: clinical symptoms, sign all remain unchanged, do not improve completely.
Therapeutic Method:
Carapax Trionycis, Carapax et Plastrum Testudinis, Concha Ostreae, Concha Margaritifera, Bulbus Fritillariae Cirrhosae are mixed with above-mentioned weight proportion, add water 500ml, is decocted first 30 minutes, afterwards residue Chinese medicine put into warm fire with above-mentioned weight proportion and boil 30 minutes, extracting juice 250m1; Two decoct the 300ml that adds water, and warm fire boils 20 minutes, extracting juice 150ml.Two decoct mixing, sooner or later empty stomach decoction being taken hot.20 doses was 1 course for the treatment of.
Efficacy result:
1. clinical efficacy result:
After treatment, cure 36 examples, effective 16 examples, effective 14 examples, invalid 4 examples; Cure rate 51.4%, obvious effective rate 22.9%, effective percentage 20.0%, inefficiency 5.7%, total effective rate 94.3%.Detailed results is in table 1.
Table 1: clinical efficacy result table after treatment
| Number of cases | Cure n (%) | Effective n (%) | Effective n (%) | Invalid n (%) | Effective percentage n (%) |
| 70 | 36(51.4) | 16(22.9) | 14(20.0) | 4(5.7) | 66(94.3) |
2. classifying type disease efficacy result:
After treatment, statistics finds, hypermetabolism syndrome treated effect is 96.0%, goiter treated effect is 92.4%, it is 94.4% that eye levies treated effect, can treat in adenofibroma of breast by Chinese medicine preparation of the present invention, curative effect is that hypermetabolism syndrome > eye levies > goiter.Detailed results is in table 2.
Table 2: classifying type disease efficacy result synopsis
3. side effect reaction
In the treatment, all there is not obvious adverse reaction in all patients.
Result shows, Chinese medicine preparation of the present invention is by Chinese medicine differential diagnosis of diseases and the dialectical principle combined, attack and mend double making, treating both the principal and the secondary aspects of a disease at the same time, be used for the treatment of that graves is evident in efficacy, cure rate is high and not easily recur, avoid surgical injury simultaneously, there is certain advantage, clinic promotion and application.
Detailed description of the invention
Embodiment 1: a kind of Chinese medicine preparation for the treatment of graves, chooses 20 grams, the Radix Rehmanniae, the Radix Paeoniae Alba 10 grams, Radix Asparagi 10 grams, Radix Ophiopogonis 10 grams, Spica Prunellae 10 grams, Carapax Trionycis 8 grams, Carapax et Plastrum Testudinis 8 grams, Concha Ostreae 8 grams, Concha Margaritifera 8 grams, Bulbus Fritillariae Cirrhosae 8 grams, Radix Salviae Miltiorrhizae 8 grams, Semen Coicis 8 grams, Herba Euphorbiae Helioscopiae 8 grams, Pseudobulbus Cremastrae Seu Pleiones 8 grams.
Embodiment 2: a kind of Chinese medicine preparation for the treatment of graves, chooses 25 grams, the Radix Rehmanniae, the Radix Paeoniae Alba 15 grams, Radix Asparagi 15 grams, Radix Ophiopogonis 15 grams, Spica Prunellae 15 grams, Carapax Trionycis 12 grams, Carapax et Plastrum Testudinis 12 grams, Concha Ostreae 12 grams, Concha Margaritifera 12 grams, Bulbus Fritillariae Cirrhosae 12 grams, Radix Salviae Miltiorrhizae 10 grams, Semen Coicis 10 grams, Herba Euphorbiae Helioscopiae 10 grams, Pseudobulbus Cremastrae Seu Pleiones 10 grams.
Embodiment 3: a kind of Chinese medicine preparation for the treatment of graves, chooses 30 grams, the Radix Rehmanniae, the Radix Paeoniae Alba 20 grams, Radix Asparagi 20 grams, Radix Ophiopogonis 20 grams, Spica Prunellae 20 grams, Carapax Trionycis 15 grams, Carapax et Plastrum Testudinis 15 grams, Concha Ostreae 15 grams, Concha Margaritifera 15 grams, Bulbus Fritillariae Cirrhosae 15 grams, Radix Salviae Miltiorrhizae 12 grams, Semen Coicis 12 grams, Herba Euphorbiae Helioscopiae 12 grams, Pseudobulbus Cremastrae Seu Pleiones 12 grams.
Below by concrete case, Chinese medicine preparation curative effect of the present invention is verified further:
Case 1
High so-and-so, women 28 years old.The symptom of hyperhidrosis that fatigue and weak just appearred in patient before 2 months, To Be Protected from Heat, moist skin, polyphagia polyphagia, weight loss, is diagnosed as through examination in hospital: hypermetabolism syndrome type goiter.Take Chinese medicine preparation of the present invention upon somebody's introduction to treat, take medicine 20 doses, without uncomfortable, symptom alleviates.Serve on 3 months, substantially fully recover.Follow up a case by regular visits to 1 year without recurrence.
Case 2
Lee so-and-so, male 40 years old.There is thyromegaly symptom over nearly 3 months in patient, and soft in the enlargement of diffusivity symmetry, matter, moves up and down when swallowing, and outside upper and lower lobes, audible and vascular murmur and touching trembles, and is diagnosed as: goiter through examination in hospital.Take Chinese medicine preparation of the present invention to this hospital to treat, take medicine 20 doses, symptom alleviates.Serve on 3 months, substantially fully recover.Follow up a case by regular visits to 1 year without recurrence.
Case 3
Zhu, women 34 years old.There is slight expophthalmos over nearly 2 months in patient, minimizing of twinkling, bright shinny, upper eyelid contracture, the symptom that fissura palpebrae is broadening.Increase relevant through this cause of disease of examination in hospital with the sympathetic excitability caused by thyrotoxicosis, be diagnosed as: eye levies type goiter.Take Chinese medicine preparation of the present invention to this hospital to treat, take medicine 25 doses, symptom alleviates.Serve on 3 months, substantially fully recover.Follow up a case by regular visits to 1 year without recurrence.
Claims (4)
1. treat a Chinese medicine preparation for graves, it is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
Radix Rehmanniae 20-30 gram, Radix Paeoniae Alba 10-20 gram, Radix Asparagi 10-20 gram, Radix Ophiopogonis 10-20 gram, Spica Prunellae 10-20 gram, Carapax Trionycis 8-15 gram, Carapax et Plastrum Testudinis 8-15 gram, Concha Ostreae 8-15 gram, Concha Margaritifera 8-15 gram, Bulbus Fritillariae Cirrhosae 8-15 gram, Radix Salviae Miltiorrhizae 8-12 gram, Semen Coicis 8-12 gram, Herba Euphorbiae Helioscopiae 8-12 gram, Pseudobulbus Cremastrae Seu Pleiones 8-12 gram.
2. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
20 grams, the Radix Rehmanniae, the Radix Paeoniae Alba 10 grams, Radix Asparagi 10 grams, Radix Ophiopogonis 10 grams, Spica Prunellae 10 grams, Carapax Trionycis 8 grams, Carapax et Plastrum Testudinis 8 grams, Concha Ostreae 8 grams, Concha Margaritifera 8 grams, Bulbus Fritillariae Cirrhosae 8 grams, Radix Salviae Miltiorrhizae 8 grams, Semen Coicis 8 grams, Herba Euphorbiae Helioscopiae 8 grams, Pseudobulbus Cremastrae Seu Pleiones 8 grams.
3. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
25 grams, the Radix Rehmanniae, the Radix Paeoniae Alba 15 grams, Radix Asparagi 15 grams, Radix Ophiopogonis 15 grams, Spica Prunellae 15 grams, Carapax Trionycis 12 grams, Carapax et Plastrum Testudinis 12 grams, Concha Ostreae 12 grams, Concha Margaritifera 12 grams, Bulbus Fritillariae Cirrhosae 12 grams, Radix Salviae Miltiorrhizae 10 grams, Semen Coicis 10 grams, Herba Euphorbiae Helioscopiae 10 grams, Pseudobulbus Cremastrae Seu Pleiones 10 grams.
4. Chinese medicine preparation according to claim 1, is characterized in that, described Chinese medicine preparation is made up of the Chinese herb of following weight portion:
30 grams, the Radix Rehmanniae, the Radix Paeoniae Alba 20 grams, Radix Asparagi 20 grams, Radix Ophiopogonis 20 grams, Spica Prunellae 20 grams, Carapax Trionycis 15 grams, Carapax et Plastrum Testudinis 15 grams, Concha Ostreae 15 grams, Concha Margaritifera 15 grams, Bulbus Fritillariae Cirrhosae 15 grams, Radix Salviae Miltiorrhizae 12 grams, Semen Coicis 12 grams, Herba Euphorbiae Helioscopiae 12 grams, Pseudobulbus Cremastrae Seu Pleiones 12 grams.
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Cited By (3)
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| CN105233084A (en) * | 2015-10-31 | 2016-01-13 | 姜秀芹 | Traditional Chinese medicine for treating toxic diffuse goiter |
| CN105288338A (en) * | 2015-10-31 | 2016-02-03 | 姜秀芹 | Traditional Chinese medicine composition for treating toxic diffuse goiter |
| CN109464623A (en) * | 2018-11-23 | 2019-03-15 | 山东今古医疗科技有限公司 | For treating thyroid nodule Chinese medicine alcohol ester body cold compress gel and preparation method |
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| CN104173720A (en) * | 2014-07-16 | 2014-12-03 | 赵巧丽 | Traditional Chinese medicinal liquor for treating simple struma |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105233084A (en) * | 2015-10-31 | 2016-01-13 | 姜秀芹 | Traditional Chinese medicine for treating toxic diffuse goiter |
| CN105288338A (en) * | 2015-10-31 | 2016-02-03 | 姜秀芹 | Traditional Chinese medicine composition for treating toxic diffuse goiter |
| CN109464623A (en) * | 2018-11-23 | 2019-03-15 | 山东今古医疗科技有限公司 | For treating thyroid nodule Chinese medicine alcohol ester body cold compress gel and preparation method |
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