CN103638320B - A kind of Chinese medicine preparation for the treatment of acute radiation-induced esophagitis - Google Patents
A kind of Chinese medicine preparation for the treatment of acute radiation-induced esophagitis Download PDFInfo
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- CN103638320B CN103638320B CN201310722824.5A CN201310722824A CN103638320B CN 103638320 B CN103638320 B CN 103638320B CN 201310722824 A CN201310722824 A CN 201310722824A CN 103638320 B CN103638320 B CN 103638320B
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Abstract
The invention discloses a kind of Chinese medicine preparation for the treatment of acute radiation-induced esophagitis.Radiation esophagitis many genus traditional Chinese medical science " dysphagic " category.Its pathogenesis is that the burning hot poison of lonizing radiation generation is evil, damage human body, intoxicating heat flourishing, cloudy Tianjin consumption wound; Or malicious blood trouble network, blood-stasis internal-depression.The present invention selects Chinese medicine Herba Strigae masuriae, Herba Pteridis multifidae, Herba Euphrasiae Regelii, Herba Plantaginis, Herba Hippuridis Vulgaris, Folium Mahoniae, Rhizoma Nupharis Bornetii, Radix Rubiae, Folium et Ramulus Callicarpae nudiflorae, the Herba Amitostigmatis Gracilis with heat-clearing and toxic substances removing, YIN nourishing and the production of body fluid promoting, blood circulation promoting and blood stasis dispelling and detumescence and promoting granulation, decocting becomes decoction, through clinical trial, total effective rate reaches 98.0%, curative effect is better, and has no adverse reaction.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine preparation for the treatment of acute radiation-induced esophagitis.
Background technology
Radiotherapy is one of breast tumor primary treatments such as pulmonary carcinoma, the esophageal carcinoma and mediastinal tumor, plays an important role in control malignant tumor progress.But the radiotherapy irradiation field of breast tumor usually inevitably involves esophagus, thus occurs acute radiation-induced esophagitis, cause very large misery to patient, patient's the lighter Deficiency of Intake, severe one causes that nutrition is bad, electrolyte disturbance, even therapy discontinued, affects radiotherapy effect.Current doctor trained in Western medicine only adopts protectant of digestive tract mucosa dioctahedral smectite and the anti-inflammatory analgetic such as antibiotic, glucocorticoid anti symptom treatment when symptom is obvious; although the misery of patient can be alleviated to a certain extent; but this sick incidence rate can not be reduced, and there is poisonous side effect of medicine.Radiotherapy is interrupted and treatment time prolongation can reduce therapeutic effect again.Chinese medicine prevention acute radiation-induced esophagitis not only curative effect certainly, to have no side effect but also cheap, for raising body toleration, reduce the incidence rate of radiation esophagitis, there is significant curative effect alleviating pain aspect.The traditional Chinese medical science is conceived to improve physical function on the whole, to other whole body simultaneous phenomenons beyond acute radiation-induced esophagitis as xerostomia, hoarseness, tired etc. also to have some improvement, the bone marrow depression cause Radiotherapy chemotherapy and Nausea and vomiting etc. have certain preventive and therapeutic action.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of acute radiation-induced esophagitis.Radiation esophagitis many genus traditional Chinese medical science " dysphagic " category.Its pathogenesis is that the burning hot poison of lonizing radiation generation is evil, damage human body, intoxicating heat flourishing, cloudy Tianjin consumption wound; Or malicious blood trouble network, blood-stasis internal-depression.The traditional Chinese medical science is the rule for the treatment of mainly with heat-clearing and toxic substances removing, YIN nourishing and the production of body fluid promoting, blood circulation promoting and blood stasis dispelling and detumescence and promoting granulation.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment acute radiation-induced esophagitis is made up of the Chinese medicine of following weight portion: Herba Strigae masuriae 15-25 part, Herba Pteridis multifidae 25-30 part, Herba Euphrasiae Regelii 3-9 part, Herba Plantaginis 9-15 part, Herba Hippuridis Vulgaris 6-12 part, Folium Mahoniae 6-9 part, Rhizoma Nupharis Bornetii 50-60 part, Radix Rubiae 6-9 part, Folium et Ramulus Callicarpae nudiflorae 15-25 part, Herba Amitostigmatis Gracilis 30-60 part.
Preferred: Herba Strigae masuriae 20 parts, Herba Pteridis multifidae 27 parts, Herba Euphrasiae Regelii 6 parts, Herba Plantaginis 12 parts, Herba Hippuridis Vulgaris 9 parts, Folium Mahoniae 7 parts, Rhizoma Nupharis Bornetii 55 parts, Radix Rubiae 7 parts, Folium et Ramulus Callicarpae nudiflorae 20 parts, Herba Amitostigmatis Gracilis 45 parts.
Above-mentioned Chinese medicine decocting is made decoction by preparation method.
Fang Zhong: Herba Strigae masuriae heat clearing away eliminating dampness by diuresis diuresis; Herba Pteridis multifidae clearing away heat and promoting diuresis is detoxified; The relieving restlessness of Herba Euphrasiae Regelii clearing away heat-damp and promoting diuresis; Herba Plantaginis clearing away heat and promoting diuresis, improving eyesight eliminate the phlegm; Herba Hippuridis Vulgaris clearing away heat and cooling blood, nutrient solution of promoting the production of body fluid; Folium Mahoniae heat clearing away tonify deficiency, relieving cough and resolving phlegm; Rhizoma Nupharis Bornetii nourishing YIN and clearing away heat; Radix Rubiae hemostasis promoting the circulation of blood, dysmenorrhea is active; Folium et Ramulus Callicarpae nudiflorae hemostasis blood stasis dispelling, analgesic antiphlogistic; Herba Amitostigmatis Gracilis subduing swelling and detoxicating stops blooding.
Clinical data
1. the routine patient of physical data 50 is the patient that the court's radiotherapy department accepts radiotherapy to the chest, is acute radiation-induced esophagitis through clinical diagnosis.The wherein esophageal carcinoma 24 example, pulmonary carcinoma 26 example, man 28 example, female 22 example, 58.5 years old mean age, radiotherapy accumulated dose 58 ~ 65Gy, length of esophagus 5 ~ 15cm in irradiation field.
2. diagnostic criteria (1) has breast tumor radiotherapy history or is carrying out radiotherapy.(2) clinical manifestation: mediastinal tumor, the non-esophagus disease such as pulmonary carcinoma occurs and the retrosternal pain of primary disease without direct relation in Patients During Radiotherapy, and feed burn feeling, swallows discomfort, and feed pain appears in severe patient, thus fears feed.In radiotherapy in esophageal carcinoma patients except there is above-mentioned symptom, eating difficulties obviously increases the weight of before comparatively treating.Have a medical check-up general without obvious sign.(3) esophagogram shows that mucosa is disorderly, and block and increase the weight of, tube chamber is less.The visible exposure Esophageal Mucosa of endoscopy is congested, edema, and even pseudomembrane is formed.
3. all patients of Therapeutic Method take Chinese medicine preparation of the present invention, take Herba Strigae masuriae 20g, Herba Pteridis multifidae 27g, Herba Euphrasiae Regelii 6g, Herba Plantaginis 12g, Herba Hippuridis Vulgaris 9g, Folium Mahoniae 7g, Rhizoma Nupharis Bornetii 55g, Radix Rubiae 7g, Folium et Ramulus Callicarpae nudiflorae 20g, Herba Amitostigmatis Gracilis 45g, decocting becomes 600ml medicinal liquid subpackage 3 bags, each 1 bag, slowly swallow for 3 times every day above-mentioned medicinal liquid, every 8h takes 1 time, and slowly swallow 10 ~ 15min at every turn, medicinal liquid is fully contacted with impaired mucosal surface, directly acts on focus.
4. criterion of therapeutical effect is effective: swallow pain and dysphagia disappears substantially; Take a turn for the better: swallow pain and (or) dysphagia obviously alleviates; Invalid: swallowing pain and dysphagia has and to alleviate or constant.
5. therapeutic effect originally organizes 50 routine patients, and treat observe the curative effect after 7 days continuously, effective 38 examples (76.0%), effective 11 examples (22.0%), invalid 1 example (2.0%), total effective rate is 98%;
Detailed description of the invention
Embodiment one: take Herba Strigae masuriae 20g, Herba Pteridis multifidae 27g, Herba Euphrasiae Regelii 6g, Herba Plantaginis 12g, Herba Hippuridis Vulgaris 9g, Folium Mahoniae 7g, Rhizoma Nupharis Bornetii 55g, Radix Rubiae 7g, Folium et Ramulus Callicarpae nudiflorae 20g, Herba Amitostigmatis Gracilis 45g, becomes decoction by above-mentioned Chinese medicine decocting.
Embodiment two: take Herba Strigae masuriae 25g, Herba Pteridis multifidae 25g, Herba Euphrasiae Regelii 9g, Herba Plantaginis 9g, Herba Hippuridis Vulgaris 12g, Folium Mahoniae 6g, Rhizoma Nupharis Bornetii 60g, Radix Rubiae 6g, Folium et Ramulus Callicarpae nudiflorae 25g, Herba Amitostigmatis Gracilis 30g, becomes decoction by above-mentioned Chinese medicine decocting.
Embodiment three: take Herba Strigae masuriae 15g, Herba Pteridis multifidae 30g, Herba Euphrasiae Regelii 3g, Herba Plantaginis 15g, Herba Hippuridis Vulgaris 6g, Folium Mahoniae 9g, Rhizoma Nupharis Bornetii 50g, Radix Rubiae 9g, Folium et Ramulus Callicarpae nudiflorae 15g, Herba Amitostigmatis Gracilis 60g, becomes decoction by above-mentioned Chinese medicine decocting.
Claims (2)
1. treat the Chinese medicine preparation of acute radiation-induced esophagitis for one kind, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Herba Strigae masuriae 15-25 part, Herba Pteridis multifidae 25-30 part, Herba Euphrasiae Regelii 3-9 part, Herba Plantaginis 9-15 part, Herba Hippuridis Vulgaris 6-12 part, Folium Mahoniae 6-9 part, Rhizoma Nupharis Bornetii 50-60 part, Radix Rubiae 6-9 part, Folium et Ramulus Callicarpae nudiflorae 15-25 part, Herba Amitostigmatis Gracilis 30-60 part, above-mentioned Chinese medicine decocting is made decoction.
2. a kind of Chinese medicine preparation for the treatment of acute radiation-induced esophagitis according to claim 1, is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Herba Strigae masuriae 20 parts, Herba Pteridis multifidae 27 parts, Herba Euphrasiae Regelii 6 parts, Herba Plantaginis 12 parts, Herba Hippuridis Vulgaris 9 parts, Folium Mahoniae 7 parts, Rhizoma Nupharis Bornetii 55 parts, Radix Rubiae 7 parts, Folium et Ramulus Callicarpae nudiflorae 20 parts, Herba Amitostigmatis Gracilis 45 parts.
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| CN103638320B true CN103638320B (en) | 2016-04-13 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104147321A (en) * | 2014-08-16 | 2014-11-19 | 杨涛 | Traditional Chinese medicine preparation for treating exuberant fire and heat type radioactive salivary gland damage |
| CN104758694A (en) * | 2015-04-15 | 2015-07-08 | 邓进巍 | Traditional Chinese medicine composition for treating acute radiation esophagitis |
| CN104800338A (en) * | 2015-05-15 | 2015-07-29 | 杨金红 | Traditional Chinese medicine composition for preventing acute radiation esophagitis |
| CN105748854A (en) * | 2016-05-03 | 2016-07-13 | 孙自营 | Buccal pill for treating acute radiation esophagitis and preparation method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1174717A (en) * | 1996-08-23 | 1998-03-04 | 李建华 | Traditional Chinese medicine for curing gastric disease |
| CN103110896A (en) * | 2013-02-15 | 2013-05-22 | 吉中华 | Preparation method of traditional Chinese medicine for treating blood stasis type reflux oesophagitis |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1174717A (en) * | 1996-08-23 | 1998-03-04 | 李建华 | Traditional Chinese medicine for curing gastric disease |
| CN103110896A (en) * | 2013-02-15 | 2013-05-22 | 吉中华 | Preparation method of traditional Chinese medicine for treating blood stasis type reflux oesophagitis |
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