CN104800338A - Traditional Chinese medicine composition for preventing acute radiation esophagitis - Google Patents
Traditional Chinese medicine composition for preventing acute radiation esophagitis Download PDFInfo
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- CN104800338A CN104800338A CN201510248844.2A CN201510248844A CN104800338A CN 104800338 A CN104800338 A CN 104800338A CN 201510248844 A CN201510248844 A CN 201510248844A CN 104800338 A CN104800338 A CN 104800338A
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing acute radiation esophagitis. The traditional Chinese medicine composition comprises the following raw materials of radix pseudostellariae, rhodiola rosea, panicled fameflower root, medicinal changium root, yerbadetajo herb, turtle shell, white bark of loquat tree, odorata lour flower, sweet clover and Chinese fever vine. The traditional Chinese medicine composition for preventing the acute radiation esophagitis has the advantages that the effect of preventing the acute radiation esophagitis is obvious, the occurrence rate of the acute radiation esophagitis is reduced, the toxic effect is avoided, and the compliance of a patient is good.
Description
Technical field
The present invention relates to Chinese medicine sciemtifec and technical sphere, particularly a kind of Chinese medicine composition preventing acute radiation-induced esophagitis.
Background technology
Radiotherapy is one of breast tumor primary treatments such as pulmonary carcinoma, the esophageal carcinoma and mediastinal tumor, plays an important role in control malignant tumor progress.But the radiotherapy irradiation field of breast tumor often inevitably involves esophagus, thus occurs acute radiation-induced esophagitis, cause very large misery to patient, patient's the lighter Deficiency of Intake, severe one causes that nutrition is bad, electrolyte disturbance, even therapy discontinued, affects radiotherapy effect.Current overall context, for the treatment of acute radiation-induced esophagitis, western medical treatment means fail to depart from the category of " three element one fiber crops ", and namely hormone, vitamin, antibiotic coordinate local anaesthetics.Though these class methods can alleviate part clinical symptoms, its untoward reaction is also comparatively obvious, as immunosuppressant, dysbacteriosis, increase the weight of infection, drug withdrawal knock-on etc., and late result is not good enough, more can not be applied to radiotherapy whole process as prophylactic.Therefore, Chinese medicine has become the new selection preventing and treating and comprise the radiation injury of radiation esophagitis in recent years.
Domestic traditional Chinese medical science scholar thinks that lonizing radiation belong to " heresy of pyretic toxicity ", and tcm therapy is the damage that causes body according to lonizing radiation (heresy of pyretic toxicity) and takes corresponding treatment measure, belongs to the passive therapeutic modality of " confront soldiers with generals and stem water with earth " formula.Chinese traditional treatment disease is to regulate body integrality, and enhancing immunity is feature, in today of chemicals extensive use, and the restriction of Chinese medicine route of administration in addition, eliminating evil counteracting toxic substances (reducing lonizing radiation to the damage of body) the non-traditional Chinese medical science chief.Therefore, according to the principle of the traditional Chinese medical science " prevention of diseae ", namely start application before development chemotherapy starts with the Chinese medicine composition preventing acute radiation-induced esophagitis to occur, there is important clinical significance.
Summary of the invention
The deficiency that the object of the invention is to overcome not for the rational Chinese medicine composition of acute radiation-induced esophagitis compatibility in prior art puts forward, and namely provides a kind of prevention acute radiation-induced esophagitis Chinese medicine composition.
In order to realize foregoing invention object, the invention provides following technical scheme:
Prevent a Chinese medicine composition for acute radiation-induced esophagitis, be made up of the crude drug of following mass ratio: Radix Pseudostellariae 10 ~ 30 parts, Radix Rhodiolae 9 ~ 15 parts, Radix Talini Paniculati 40 ~ 60 parts, Radix Changii 8 ~ 12 parts, Herba Ecliptae 8 ~ 12 parts, Carapax Trionycis 20 ~ 30 parts, Cortex Eriobotryae 3 ~ 9 parts, Flos Aglaiae Odoratae spend 3 ~ 9 parts, melilotus 9 ~ 15 parts, fevervine 30 ~ 50 parts.
The pharmacological action of raw material of Chinese medicine medicine of the present invention is as follows:
Radix Pseudostellariae: sweet, micro-hardship, flat, returns spleen, lung meridian.Air making-up and spleen enlivening, promoting the production of body fluid for nourishing the lung.For spleen syndrome of deficiency of both qi and yin of lung.
Radix Rhodiolae: sweet, cold, returns spleen, lung meridian.Invigorating the spleen and benefiting QI, clearing away lung-heat to relieve cough, blood circulation promoting and blood stasis dispelling.Cure mainly syndrome of deficiency of spleen qi, deficiency of lung-YIN cough due to lung-heat.
Radix Talini Paniculati: sweet, flat.Invigorating the spleen and replenishing QI, nourishing YIN and moistening the lung, reducing swelling and alleviating pain.Cure mainly insufficiency of the spleen lack of appetite weak, have loose bowels, proctoptosis, pulmonary tuberculosis hemoptysis, hectic fever, night sweat, spontaneous perspiration, the enuresis, hypogalactia in puerperal, carbuncle furuncle.
Radix Changii: sweet, micro-hardship, to be slightly cold, returns lung, spleen, Liver Channel.Moistening the lung and resolving phlegm, yin nourishing stomach function regulating, suppressing the hyperactive liver.Cure mainly syndrome of deficiency of lung yin, syndrome of yin deficiency of spleen and stomach, deficiecny of liver-YIN or liver-heat are attacked the card such as dizzy, headache, conjunctival congestion extremely.
Herba Ecliptae: sweet, sour, cold, returns liver, kidney channel.Nourishing the liver and kidney, cooling blood for hemostasis.Cure mainly syndrome of yin deficiency of liver and kidney, the card of losing blood of YinXuXueRe.
Carapax Trionycis: sweet, salty, cold, returns liver, kidney channel.Nourishing YIN for suppressing the hyperactive YANG, brings down a fever except steaming, hard masses softening and resolving.Cure mainly syndrome of yin deficiency of liver and kidney ， lumps in the chest and abdomen.
Cortex Eriobotryae: bitter, flat.Normalizing the stomach by guiding QI downward, cough-relieving, removing toxic substances.Cure mainly vomiting, singultus, chronic cough, chronic diarrhea, carbuncle pyogenic infections from tumour or sore.
Flos Aglaiae Odoratae flower: promoting the circulation of QI to alleviate the stagnation in middle-JIAO, lung qi dispersing cough-relieving.Cure mainly chest and diaphragm full vexed, the cancer of the esophagus is from the beginning of, cold cough.
Melilotus: pungent, flat.Stomach function regulating spleen invigorating, clearing away heat and eliminating dampness, diuresis.Cure mainly heat-damp in summer uncomfortable in chest, greasy taste in the mouth, halitosis, dysentery with red and white feces, gonorrhea, furuncle.
Fevervine: sweet, bitter, be slightly cold, returns spleen, stomach, liver, lung meridian.Promoting digestion and invigorating the stomach, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing, pain relieving.Cure mainly eating accumulation, infantile malnutrition; Phlegm heat cough; Pyretic toxicity dysentery, laryngopharynx swelling and pain, carbuncle furuncle swells, burn and scald etc.; Gastrointestinal distress, biliary colic, renal colic, dysmenorrhea, labor pains, neuralgia and various wound, fracture, postoperative pain etc.
Acute radiation-induced esophagitis belongs to the traditional Chinese medical science " dysphagic ", " regurgitation ", " vomiting " category.The traditional Chinese medical science thinks that lonizing radiation belong to the heresy of pyretic toxicity, and the change of disease is rapid, does not follow the change of disease rule of " defensive-qi-nutrient-blood ", easily consumption impairment of YIN blood.Medication while radiotherapy " example is thirsty and wear well, bucket and casting cone, also evening? " the traditional Chinese medical science is thought, " healthy energy deposit in, heresy can not be done ", emphasizes " healthy energy " importance in diseases prevention and treatment.According to the principle of the traditional Chinese medical science " prevention of diseae ", should adjust before radiotherapy and mend human body " healthy energy ", during to strive for radiotherapy " heresy can not be done ", reduce lonizing radiation to the damage of esophagus.The present invention adopts Radix Pseudostellariae, Radix Rhodiolae, Radix Talini Paniculati's supplementing QI and nourishing YIN; Radix Changii, Herba Ecliptae, Carapax Trionycis phencyclidine, Carapax Trionycis is held concurrently hard masses softening and resolving; Cortex Eriobotryae normalizing the stomach by guiding QI downward; Flos Aglaiae Odoratae flower, melilotus, the spleen invigorating of fevervine stomach function regulating, fevervine also can alleviating pain.All medicines share, and make gas Wang Yin foot, taste are in harmonious proportion, and body healthy energy is sufficient, thus scorchingly hot heresy not easily in invade.
Preferably, the Chinese medicine composition of described prevention acute radiation-induced esophagitis is made up of the crude drug of following mass ratio: Radix Pseudostellariae 15 ~ 25 parts, Radix Rhodiolae 11 ~ 13 parts, Radix Talini Paniculati 45 ~ 55 parts, Radix Changii 9 ~ 11 parts, Herba Ecliptae 9 ~ 11 parts, Carapax Trionycis 23 ~ 27 parts, Cortex Eriobotryae 5 ~ 7 parts, Flos Aglaiae Odoratae spend 5 ~ 7 parts, melilotus 11 ~ 13 parts, fevervine 35 ~ 45 parts.
Further preferred, the Chinese medicine composition of described prevention acute radiation-induced esophagitis is made up of the crude drug of following mass ratio: Radix Pseudostellariae 20 parts, Radix Rhodiolae 12 parts, Radix Talini Paniculati 50 parts, Radix Changii 10 parts, Herba Ecliptae 10 parts, Carapax Trionycis 25 parts, Cortex Eriobotryae 6 parts, Flos Aglaiae Odoratae spend 6 parts, melilotus 12 parts, fevervine 40 parts.
The Chinese medicine composition of described prevention acute radiation-induced esophagitis can adopt existing Chinese medicine preparation technology to be prepared into any conventional oral preparations, such as can decocting be adopted to obtain water decoction said components, by other existing Chinese medicine preparation technology, the Chinese medicine composition of described prevention acute radiation-induced esophagitis can also be prepared into tablet, water-honeyed pill, capsule, powder, unguentum, oral liquid, granule.
compared with prior art, beneficial effect of the present invention
The Chinese medicine composition prevention acute radiation-induced esophagitis successful of prevention acute radiation-induced esophagitis provided by the invention, can reduce the incidence rate of radioactivity esophagitis, have no side effect, patient compliance is good.
prevent a Chinese medicine composition for acute radiation-induced esophagitis, clinical efficacy is summed up
1 physical data
The central type nonsmall-cell lung cancer that 64 examples are made a definite diagnosis through clinical pathology mediastinal lymph node metastasis patient is divided into treatment group and matched group at random, often organizes 32 examples.Treatment group man 22 example, female 10 example; 31 ~ 71 years old age, 53.4 years old mean age.Matched group man 23 example, female 9 example; 32 ~ 70 years old age, 54.0 years old mean age.Two groups of life qualities press KPS scoring, and treatment group is average (78.18 ± 5.20) point, and matched group is average (78.49 ± 5.39) point.No significant difference in two groups of clinical stagess in sex, age, primary disease, disease, chemicotherapy therapeutic scheme, life quality scorings etc., has comparability (P > 0.05).
2 Therapeutic Method
Matched group radiotherapy gives oral conventional Western medicine (normal saline 250ml, vitamin B simultaneously
215mg, gentamycin 160,000 U, dexamethasone 10mg and 2% lignocaine 10ml are mixed), 20ml/ time, 4 times/day.The Chinese medicine composition water decoction of 2 weeks and the oral prevention acute radiation-induced esophagitis provided by the invention of radiation period before treatment group radiotherapy, composed as follows: Radix Pseudostellariae 20 grams, Radix Rhodiolae 12 grams, Radix Talini Paniculati 50 grams, Radix Changii 10 grams, Herba Ecliptae 10 grams, Carapax Trionycis 25 grams, Cortex Eriobotryae 6 grams, Flos Aglaiae Odoratae spend 6 grams, melilotus 12 grams, fevervine 40 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
3 therapeutic outcomes
3.1 criterions of therapeutical effect: with reference to U.S. radiation oncology treatment cooperative groups (RTOG) acute radiation injury grade scale ［ James D, Joam-Stetz B Z, Pajak T F.Toxicity criteria of the radiation therapy oncology group (RTOG) and European organization for research and treatment of cancer (EORTC) .Int J Radiat Oncol Biol Fhys, 1995,31:1341. ］: 0 grade is unchanged; I grade is slight dysphagia or swallow pain, maybe needs by topical anesthetic cream or non-narcotic analgesic, may need into soft diet; II grade is moderate dysphagia or swallow pain, and may need, with narcotic-based painkillers, may need into thick soup or liquid food; III grade for severe dysphagia or swallow pain companion dehydration, or weight ratio treatment before decline > 15%, need row nasal feeding tube, intravenous drip liquid or high nutrient; IV grade for blocking completely, ulcer, perforation, fistula.
3.2 results: esophagus acute toxic reaction in various degree all appears in two groups of patients, and treatment group incidence rate is 15.63%, and matched group incidence rate is 46.88%, two groups and compares, and difference has statistical significance (P < 0.05).Treatments period treatment group does not find the impact on the heart, Liver and kidney function.The results are shown in subordinate list.
There is acute radiation esophagitis situation (n=32) in subordinate list two groups of patients
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.
Embodiment 1
A kind of Chinese medicine composition preventing acute radiation-induced esophagitis, be by Radix Pseudostellariae 30 grams, Radix Rhodiolae 15 grams, Radix Talini Paniculati 60 grams, Radix Changii 12 grams, Herba Ecliptae 12 grams, Carapax Trionycis 30 grams, Cortex Eriobotryae 9 grams, Flos Aglaiae Odoratae spend 9 grams, melilotus 15 grams, fevervine 50 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
Embodiment 2
A kind of Chinese medicine composition preventing acute radiation-induced esophagitis, be by Radix Pseudostellariae 25 grams, Radix Rhodiolae 13 grams, Radix Talini Paniculati 55 grams, Radix Changii 11 grams, Herba Ecliptae 11 grams, Carapax Trionycis 27 grams, Cortex Eriobotryae 7 grams, Flos Aglaiae Odoratae spend 7 grams, melilotus 13 grams, fevervine 45 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
Embodiment 3
A kind of Chinese medicine composition preventing acute radiation-induced esophagitis, be by Radix Pseudostellariae 20 grams, Radix Rhodiolae 12 grams, Radix Talini Paniculati 50 grams, Radix Changii 10 grams, Herba Ecliptae 10 grams, Carapax Trionycis 25 grams, Cortex Eriobotryae 6 grams, Flos Aglaiae Odoratae spend 6 grams, melilotus 12 grams, fevervine 40 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
Embodiment 4
A kind of Chinese medicine composition preventing acute radiation-induced esophagitis, be by Radix Pseudostellariae 15 grams, Radix Rhodiolae 11 grams, Radix Talini Paniculati 45 grams, Radix Changii 9 grams, Herba Ecliptae 9 grams, Carapax Trionycis 23 grams, Cortex Eriobotryae 5 grams, Flos Aglaiae Odoratae spend 5 grams, melilotus 11 grams, fevervine 35 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
Embodiment 5
A kind of Chinese medicine composition preventing acute radiation-induced esophagitis, be by Radix Pseudostellariae 10 grams, Radix Rhodiolae 9 grams, Radix Talini Paniculati 40 grams, Radix Changii 8 grams, Herba Ecliptae 8 grams, Carapax Trionycis 20 grams, Cortex Eriobotryae 3 grams, Flos Aglaiae Odoratae spend 3 grams, melilotus 9 grams, fevervine 30 grams, conveniently Chinese medicine preparation technology makes water decoction, everyone potion every day.
Claims (4)
1. prevent a Chinese medicine composition for acute radiation-induced esophagitis, it is characterized in that being made up of the crude drug of following mass ratio:
Radix Pseudostellariae 10 ~ 30 parts, Radix Rhodiolae 9 ~ 15 parts, Radix Talini Paniculati 40 ~ 60 parts, Radix Changii 8 ~ 12 parts, Herba Ecliptae 8 ~ 12 parts, Carapax Trionycis 20 ~ 30 parts, Cortex Eriobotryae 3 ~ 9 parts, Flos Aglaiae Odoratae spend 3 ~ 9 parts, melilotus 9 ~ 15 parts, fevervine 30 ~ 50 parts.
2. the Chinese medicine composition of prevention acute radiation-induced esophagitis as claimed in claim 1, is characterized in that being made up of the crude drug of following mass ratio:
Radix Pseudostellariae 15 ~ 25 parts, Radix Rhodiolae 11 ~ 13 parts, Radix Talini Paniculati 45 ~ 55 parts, Radix Changii 9 ~ 11 parts, Herba Ecliptae 9 ~ 11 parts, Carapax Trionycis 23 ~ 27 parts, Cortex Eriobotryae 5 ~ 7 parts, Flos Aglaiae Odoratae spend 5 ~ 7 parts, melilotus 11 ~ 13 parts, fevervine 35 ~ 45 parts.
3. the Chinese medicine composition of prevention acute radiation-induced esophagitis as claimed in claim 1, is characterized in that being made up of the crude drug of following mass ratio:
Radix Pseudostellariae 20 parts, Radix Rhodiolae 12 parts, Radix Talini Paniculati 50 parts, Radix Changii 10 parts, Herba Ecliptae 10 parts, Carapax Trionycis 25 parts, Cortex Eriobotryae 6 parts, Flos Aglaiae Odoratae spend 6 parts, melilotus 12 parts, fevervine 40 parts.
4. prevent the preparation method of the Chinese medicine composition of acute radiation-induced esophagitis as claimed in claim 1, it is characterized in that the Chinese medicinal components of described mass ratio to be prepared into water decoction, tablet, water-honeyed pill, capsule, powder, unguentum, oral liquid, granule.
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| 路军章等: "中医药防治急性放射性食管炎", 《中华中医药杂志》 * |
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Application publication date: 20150729 |