CN103656461B - A kind of Chinese medicine pill and preparation method for the treatment of gastric cancer - Google Patents
A kind of Chinese medicine pill and preparation method for the treatment of gastric cancer Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine pill and preparation method for the treatment of gastric cancer, belong to the field of Chinese medicines.The crude drug making medicament effective component by following weight is: the Rhizoma Atractylodis Macrocephalae 15 grams, Radix Angelicae Sinensis 15 grams, Rhizoma Corydalis 15 grams, Herba Scutellariae Barbatae 15 grams, the Radix Linderae 15 grams, Fructus Amomi 15 grams, Fructus Evodiae 15 grams, Fructus Ligustri Lucidi 15 grams, Carapax Trionycis 15 grams, Radix Rehmanniae 10 grams, Myrrha 10 grams, Rhizoma Polygonati 10 grams, Rhizoma Sparganii 10 grams, Olibanum 10 grams, Radix Notoginseng 10 grams, Endoconcha Sepiae 10 grams, Thallus Laminariae (Thallus Eckloniae) 10 grams, the Radix Aucklandiae 10 grams, Herba Menthae 10 grams, 10 grams, Semen Persicae, 6 grams, Flos Carthami, Radix Et Rhizoma Rhei 6 grams, Herba Asari 6 grams, Scolopendra 10 grams, 6 grams, Radix Glycyrrhizae.The present invention has the effect of heat-clearing and toxic substances removing, vigorate qi and replenish the blood, blood circulation promoting and blood stasis dispelling, the body resistance strengthening and constitution consolidating, can prevent the transfer of gastric cancer focus, effectively can control the health of patient self, have instant effect, feature evident in efficacy.<pb pnum="1" />
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specially a kind of Chinese medicine pill and preparation method for the treatment of gastric cancer.
Background technology
Gastric cancer ranks first in the various malignant tumor of China, and incidence gastric cancer has obvious region difference, is evident as height in the northwest of China and coastal region in east China incidence gastric cancer rate than southern area.Send out well the age more than 50 years old, the ratio of men and women's sickness rate is 2:1.The prognosis of gastric cancer is relevant with the pathological staging of gastric cancer, position, organization type, biological behaviour and remedy measures.The most patient's non-evident sympton of early gastric cancer, a few peoples have the digestive symptoms of Nausea and vomiting or similar Peptic Ulcers.Pain is the modal clinical symptoms of advanced gastric carcinoma with losing weight.The digestive symptoms that patient Chang You is comparatively clear and definite, as epigastric discomfort, feed after glutted, along with disease progression Upper abdominal pain increases the weight of, appetite decline, weak.
Current doctor trained in Western medicine gastric cancer conventional therapy many by operative treatment in conjunction with radiotherapy and chemotherapy.Part patients with gastric cancer is after above-mentioned treatment, and the state of an illness can be effectively controlled, but also some state of an illness can worsen further, and proceeds to late period, and be the patient in late period when also having some to find, these patients use above-mentioned therapy how not ideal enough.Adopt traditional Chinese medicine therapy, can the toxic reaction that causes of prevention and therapy chemotherapy and radiation and side effect, effectively prevent recurrence and transfer, can life quality be improved.
Summary of the invention
The object of the invention is to overcome the deficiency that prior art exists, and a kind of Chinese medicine pill and preparation method for the treatment of gastric cancer be provided, this medicine can rapidly, relief of symptoms effectively, there is the advantage of instant effect, Be very effective.
The technical scheme that technical solution problem of the present invention is taked is: a kind of Chinese medicine pill for the treatment of gastric cancer, it is characterized in that, the crude drug making medicament effective component by following weight is: the Rhizoma Atractylodis Macrocephalae 15 grams, Radix Angelicae Sinensis 15 grams, Rhizoma Corydalis 15 grams, Herba Scutellariae Barbatae 15 grams, the Radix Linderae 15 grams, Fructus Amomi 15 grams, Fructus Evodiae 15 grams, Fructus Ligustri Lucidi 15 grams, Carapax Trionycis 15 grams, Radix Rehmanniae 10 grams, Myrrha 10 grams, Rhizoma Polygonati 10 grams, Rhizoma Sparganii 10 grams, Olibanum 10 grams, Radix Notoginseng 10 grams, Endoconcha Sepiae 10 grams, Thallus Laminariae (Thallus Eckloniae) 10 grams, the Radix Aucklandiae 10 grams, Herba Menthae 10 grams, 10 grams, Semen Persicae, 6 grams, Flos Carthami, Radix Et Rhizoma Rhei 6 grams, Herba Asari 6 grams, Scolopendra 10 grams, 6 grams, Radix Glycyrrhizae.
Compound method:
1, medicinal for above-mentioned raw materials powder beater is broken into fine powder;
2, Mel is endured boil with high heat, then change slow fire into and endure slowly, raw honey heating is endured boil to foam be light red gloss;
3, medicated powder is mixed with the mass ratio of the refined honey refined by 1:1.During conjunction medicine, Mel adds while hot, fully with even, makes its color and luster consistent, neither too hard, nor too soft, can random kneading model.
4, the medicine of the dough sample got togather is placed, spice is mixed with honey component and moistens, and use full automatic machine for producing pills pill after producing certain viscosity.
5, treat pill diaphoresis, appearance is hardening, then wraps with paraffin paper, cellophane, plastic bag or wax shell etc., is stored in shady and cool dry place.
Instructions of taking: each serving with 15, three times on the one, each one after each meal.It within 30 days, is a course for the treatment of.
Pharmacological action:
The Rhizoma Atractylodis Macrocephalae: bitter sweet, temperature.Enter spleen, stomach warp.Spleen reinforcing, stomach reinforcing, dampness, and in, antiabortive.Control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, spontaneous perspiration, and nausea is uneasy.
Radix Angelicae Sinensis: sweet, acrid, warm.Enter the heart, liver, spleen channel.Benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes laxation.Control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia; Headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome; Dryness of the intestine dyschezia is heavy after bloody dysentery; Carbuncle skin ulcer is stolen, injury from falling down.
Rhizoma Corydalis: arduous, temperature.Enter liver, stomach warp.Invigorate blood circulation, dissipating blood stasis, regulates the flow of vital energy, pain relieving.Control all pains of trusted subordinate's waist knee joint, menoxenia ， mass in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.
Herba Scutellariae Barbatae: pungent, bitter, cold.Return lung, liver, kidney channel.Function with cure mainly: heat-clearing and toxic substances removing, blood stasis dispelling diuresis.For furuncle swelling toxin, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, edema, jaundice.
The Radix Linderae: acrid in the mouth, temperature, nontoxic.Enter spleen, lung, kidney, urinary bladder channel.Pleasant, dissipating depression of QI, cold expelling, pain relieving.Control QI rising in reverse order chest and abdomen swelling and pain, dyspepsia does not disappear, and food is told in regurgitation, colic of cold type, beriberi, frequent micturition.
Semen Persicae: bitter sweet is flat.Enter the heart, liver, large intestine channel.Blood stasis removing and clots absorbing, moisturizes laxation.Control amenorrhea ， mass in the abdomen, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.
Flos Carthami: pungent, temperature.Enter the heart, Liver Channel.Promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving.Control amenorrhea ， mass in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, injury from falling down.
Fructus Amomi: pungent, temperature.Enter spleen, stomach warp.During circulation of qi promoting is adjusted, stomach function regulating, is amusing.Control stomachache painful abdominal mass swollen, anorexia dyspepsia, dysphagic vomiting, diarrhea due to cold pathogen cold-dysentery, pregnant fetal movement.
Fructus Evodiae: pungent, bitter, heat.Slightly poisonous.Return liver, spleen, stomach, kidney channel.Dispersing cold for relieving pain, warming middle-JIAO to arrest vomiting, dampness removing and diarrhea-relieving.Be apt to into Liver Channel, both the cold-evil of loose Liver Channel, separated again the stasis of Liver Channel, and had good analgesic effect.
Carapax Trionycis: salty, is slightly cold.Return liver, kidney channel.Nourishing YIN for suppressing the hyperactive YANG, brings down a fever except steaming, hard masses softening and resolving.For fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever, hyperactivity of YANG due to deficiency of YIN, has a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency.
Fructus Ligustri Lucidi: bitter sweet, flat.Enter liver, kidney channel.Invigorating the liver and kidney, strong waist knee joint.Control yin asthenia generating intrinsic heat, dizzy, order flower, tinnitus, soreness of the waist and knees, early whitening of beard and hair.Nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.
The Radix Rehmanniae: clearing up internal heat by using drugs of bitter in taste and cold in nature, Gan Hanzhi moistens yin nourishing, is the refrigerant product moistened, is good at nourishing YIN and clearing away heat removing heat from blood.Effect clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting, intestine moistening.
Myrrha: bitter, pungent is flat, nontoxic.Liver, spleen, the heart, kidney channel.Invigorate blood circulation analgesic therapy, detumescence and promoting granulation, cures mainly traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, and skin infection does not close up after bursting for a long time.
Rhizoma Polygonati: invigorating the spleen and replenishing QI, profit cardiopulmonary, bone and muscle strengthening.Control deficient cold and heat, pulmonary tuberculosis hemoptysis, after being ill the empty lack of appetite of body, muscles and bones is weak, rheumatalgia, wind favus disease.
Herba Scutellariae Barbatae: heat clearing away, removing toxic substances, dissipating blood stasis, hemostasis, analgesic therapy.Control haematemesis, epistaxis, stranguria with blood, bloody dysentery, lung abscess, cancerous protuberance, traumatic injury knife injury, venom.
Rhizoma Sparganii: toil is flat.Enter liver.Spleen channel.Removing blood stasis, circulation of qi promoting, removing food stagnancy, pain relieving.Zhi lumps in the chest and abdomen, coagulation of QI-blood, trusted subordinate's pain, the lower swollen pain of the side of body, amenorrhea, postnatal blood stasis is suffered from abdominal pain, traumatic injury.Skin ulcer swells hard.
Olibanum: regulating qi and activating blood, analgesic therapy, chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.
Radix Notoginseng: sweet micro-hardship, temperature.Enter liver, stomach, large intestine channel.Hemostasis, dissipating blood stasis, detumescence, analgesic therapy.Control haematemesis, hemoptysis, epistaxis, have blood in stool, dysentery, metrorrhagia ， mass in the abdomen, puerperal blood faints, retention of lochia, falls and flutters blood stasis, traumatic hemorrhage, carbuncle pain.
Herba Menthae: pungent is cool.Enter lung, Liver Channel.Dispelling wind, heat radiation, wards off dirty, removing toxic substances.Control affection due to external wind and heat, headache, conjunctival congestion, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria.
Endoconcha Sepiae: salty, tepor.Enter liver, kidney channel.Dehumidifying, antacid, hemostasis, sore.Treat for stomachache acid regurgitation, tells, is defeated in battle, hematemesis, has blood in stool, bleeding not during menses, amenorrhea due to blood depletion, Fu Tong mass in the abdomen, intermittent fever of deficiency type dysentery, the rotten skin ulcer of the erosion of the vulva.
Thallus Laminariae (Thallus Eckloniae): salty, cold.Enter stomach warp.Softening the hard mass, row water.Control scrofula, goiter, dysphagic, edema, painful and swollen testis, leukorrhagia.
The Radix Aucklandiae: gas fragrance, taste is sweet, bitter, slightly stings tongue.Warm in nature, acrid in the mouth, hardship.Promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.For weighing after breast gastral cavity distending pain, dysentery, food stagnation does not disappear, anorexia.
Radix Et Rhizoma Rhei: bitter in the mouth, cold.Enter stomach, large intestine, Liver Channel.Purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.Purge heat poison, and removing mass is stagnant, clots absorbing blood.Control excess-heat constipation, delirium sends out holder, food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi ， lumps in the chest and abdomen, time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, spit blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, also urinates, carbuncle and ulcer toxic swelling, furuncle, burn.
Herba Asari: pungent, temperature.Enter lung, kidney channel.There is the effects such as expelling cold and relieving exterior syndrome, expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, anti-inflammatory analgetic, heat-clearing and toxic substances removing. control air-cooled headache, nasal sinusitis, laugh somebody to scorn, rheumatic arthralgia.
Scolopendra: salty pungent, flat, poisonous.Meridian of Foot-JUE YIN.The two function is similar, has relieving spasm by subduing liver-wind, and effect of detoxicating and resolving stagnation of pathogens pain network pain relieving, can draw out pus by applying a plaster to the affected part by counteracting toxic substances, separate the stasis of blood and fall apart stagnant, open expectorant eliminating stagnation, broken hard detumescence.For intractable pain, there is obvious analgesic efficacy.
Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, grows and coughs lung moistening, and emergency is detoxified, and is in harmonious proportion hundred medicines.Cure mainly laryngopharynx swelling and pain, cellulitis skin infection, gastrointestinal ulceration and solution poison of drug, alimentary toxicosis etc.Radix Glycyrrhizae agent have antiinflammatory and resistance state reflection function, therefore in doctor trained in Western medicine clinically mainly as demulcent.
The present invention can the immunologic function of enhancing body, and adjustment body integral status, strengthens the body constitution of patient.Effectively prevent postoperative recurrence, the diffusion of cancerous cell and transfer.Formula and prescription of the present invention is reasonable, there is the effect of heat-clearing and toxic substances removing, vigorate qi and replenish the blood, blood circulation promoting and blood stasis dispelling, the body resistance strengthening and constitution consolidating, the transfer of gastric cancer focus can be prevented, effectively can control the health of patient self, very large potentiation is all served to the relapse and metastasis situation of patients with gastric cancer and curing gastric cancer.There is instant effect, feature evident in efficacy.
One, clinical observation
1, clinical data: the outpatient service and inpatient totally 128 examples that are selected from year May in June, 2012 to 2013, wherein early gastric cancer 46 example.Patient age between 26-77 year, 56.5 years old mean age.
2, Therapeutic Method: take Chinese medicine pill of the present invention, point three Morning Afternoon Evenings are taken.It within 1 month, is 1 course for the treatment of.
3, criterion of therapeutical effect: the standard formulated according to Ministry of Public Health 1991 version " Chinese common cancer diagnosis and treatment specification ", is divided into:
1. complete incidence graph, visual tumors disappears, and continues more than one month;
2. partial rcsponse, the maximum orthogonal diameter product of two, tumor reduces more than 50%, and keeps more than 1 month;
3. stablize, the maximum orthogonal diameter product of two, tumor reduces less than 50%, increases and is no more than 25%, and continues more than one month;
4. worsen, the maximum orthogonal diameter product of two, tumor increases above 25%.
4, therapeutic outcome: complete incidence graph 106 example, partial rcsponse 12 example, stablizes 8 examples, worsens 2 examples.Effective percentage (CR+PR) is 92.2%, and coefficient of stabilization (CR+PR+SD) is 98.4%.There are 38 examples to cure (tumor all disappears, and follows up a case by regular visits to and does not recur for 1 year) in early stage 46 routine early gastric cancer simultaneously.
5, toxic and side effects analysis
In the 128 routine patients observed, only have 2 examples to occur low grade fever, 1 routine laxativeness, occur that the probability of side reaction is only 2.3% after taking Chinese medicine of the present invention, dispose side reaction through suiting the medicine to the illness and disappear, all the other are without any side effects.
In sum, the present invention treats the Chinese medicine pill of gastric cancer, through clinical trial, shows that it effectively can suppress stomach cancer development, improves patients symptomatic, sign, and without obvious toxic-side effects.
Model case
Example one, Wang Zhiguo, man, 58 years old.Patient feels difficulty of swallowing of having a meal, and appetite declines day by day, feels that throat blocks up flurried, more and more heavier afterwards, do not have a meal and also ache when eating.Gastric cancer is diagnosed as through hospital gastroscope inspection.The tumor of a 3.1cmx1.5cm is had at stomach cardia place.Doctor advised operative treatment, sons and daughters consider that father worries that operation brings danger old, adhere to not performing the operation, take Drug therapy of the present invention afterwards.After taking a course for the treatment of, much gentlier, throat has brisk sensation to the obvious feels pain of old man, and drink gruel and also bitterly do not continue to take medicine after a course for the treatment of, above-mentioned symptom all obviously alleviates or disappears.Tumor body is contracted to 2.0cmx0.8cm on inspection, and after taking five course for the treatment of medicines, old man's spirit is pleasant, can eat and can sleep, and health is as non-premorbid, and old man is also very hale and hearty so far.
Example two, Jiang Liyan, 39 years old, female.Patient has just had gastrotherapy history since 20 years old.Before start stomachache more than a year severe, medication is ineffective.Stomach swelling, has a meal and does not have appetite, two wheat harvesting periods thin fall 13, four jin.Gerontal gastric cancer is diagnosed as through hospital.The maximum Tumor diameter 3.5cmx2.5cm of gastric.Large omentum minus lymph node finds that there is neoplasm metastasis, has done stomach large portion resection operation and accept chemotherapy at the beginning of 8 months in hospital.The toxic and side effects of chemotherapy causes patient's serious insomnia, feels sick, physical weakness.Have to stop the chemotherapy plan of original six courses for the treatment of.Take medicine after two course for the treatment of medicines, the state of an illness of patient is greatly improved, and pain condition disappears.Through hospital's CT examination, the maximum lump in stomach narrows down to 2.3cmx1.8cm, and those are dispersed in all disappearing on coat of the stomach in graininess tumor and lymph.Take medicine after four courses for the treatment of, diet, all than compared with normal, has been cooked comprehensive inspection in hospital, tumor disappearance, patient add again one the course for the treatment of medicine with after treatment effect, follow up a case by regular visits to 1 year, have no recurrence.
Detailed description of the invention
Example one: a kind of Chinese medicine pill and preparation method for the treatment of gastric cancer, it is characterized in that, the crude drug making medicament effective component by following weight parts is: the Rhizoma Atractylodis Macrocephalae 15 grams, Radix Angelicae Sinensis 15 grams, Rhizoma Corydalis 15 grams, Herba Scutellariae Barbatae 15 grams, the Radix Linderae 15 grams, Fructus Amomi 15 grams, Fructus Evodiae 15 grams, Fructus Ligustri Lucidi 15 grams, Carapax Trionycis 15 grams, Radix Rehmanniae 10 grams, Myrrha 10 grams, Rhizoma Polygonati 10 grams, Rhizoma Sparganii 10 grams, Olibanum 10 grams, Radix Notoginseng 10 grams, Endoconcha Sepiae 10 grams, Thallus Laminariae (Thallus Eckloniae) 10 grams, the Radix Aucklandiae 10 grams, Herba Menthae 10 grams, 10 grams, Semen Persicae, 6 grams, Flos Carthami, Radix Et Rhizoma Rhei 6 grams, Herba Asari 6 grams, Scolopendra 10 grams, 6 grams, Radix Glycyrrhizae.
Compound method:
1, medicinal for above-mentioned raw materials powder beater is broken into fine powder;
2, Mel is endured boil with high heat, then change slow fire into and endure slowly, raw honey heating is endured boil to foam be light red gloss;
3, medicated powder is mixed with the mass ratio of the refined honey refined by 1:1.During conjunction medicine, Mel adds while hot, fully with even, makes its color and luster consistent, neither too hard, nor too soft, can random kneading model.
4, the medicine of the dough sample got togather is placed, spice is mixed with honey component and moistens, and use full automatic machine for producing pills pill after producing certain viscosity.
5, treat pill diaphoresis, appearance is hardening, then wraps with paraffin paper, cellophane, plastic bag or wax shell etc., is stored in shady and cool dry place.
Instructions of taking: each serving with 15, three times on the one, each one after each meal.It within 30 days, is a course for the treatment of.
Claims (2)
1. treat a Chinese medicine pill for gastric cancer, it is characterized in that, crude drug and the weight thereof of making effective ingredient are: the Rhizoma Atractylodis Macrocephalae 15 grams, Radix Angelicae Sinensis 15 grams, Rhizoma Corydalis 15 grams, Herba Scutellariae Barbatae 15 grams, the Radix Linderae 15 grams, Fructus Amomi 15 grams, Fructus Evodiae 15 grams, Fructus Ligustri Lucidi 15 grams, Carapax Trionycis 15 grams, Radix Rehmanniae 10 grams, Myrrha 10 grams, Rhizoma Polygonati 10 grams, Rhizoma Sparganii 10 grams, Olibanum 10 grams, Radix Notoginseng 10 grams, Endoconcha Sepiae 10 grams, Thallus Laminariae (Thallus Eckloniae) 10 grams, the Radix Aucklandiae 10 grams, Herba Menthae 10 grams, 10 grams, Semen Persicae, 6 grams, Flos Carthami, Radix Et Rhizoma Rhei 6 grams, Herba Asari 6 grams, Scolopendra 10 grams, 6 grams, Radix Glycyrrhizae.
2. prepare a method for the Chinese medicine pill for the treatment of gastric cancer according to claim 1, it is characterized in that,
(1) medicinal for above-mentioned raw materials powder beater is broken into fine powder;
(2) Mel is endured boil with high heat, then change slow fire into and endure slowly, Mel heating is endured boil to foam be light red gloss;
(3) medicated powder is mixed with the mass ratio of the refined honey refined by 1:1;
(4) place, medicated powder is mixed with honey component and moistens, and pill after producing viscosity;
(5) treat pill diaphoresis, appearance is hardening, then wraps.
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| CN1344547A (en) * | 2001-06-12 | 2002-04-17 | 衣宣凯 | Multieffect stomach-invigorating bolus |
| CN1651064A (en) * | 2004-12-23 | 2005-08-10 | 黄文珍 | Medicinal composition for treating tumour and its preparation method |
| CN101049484A (en) * | 2007-05-14 | 2007-10-10 | 郝来勤 | Strong effective Chinese traditional medicine for treating lung cancer and other various cancers |
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| CN1651064A (en) * | 2004-12-23 | 2005-08-10 | 黄文珍 | Medicinal composition for treating tumour and its preparation method |
| CN101049484A (en) * | 2007-05-14 | 2007-10-10 | 郝来勤 | Strong effective Chinese traditional medicine for treating lung cancer and other various cancers |
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