CN104306719A - Traditional Chinese medicine combination for curing stomach cancer, and preparation method and application thereof - Google Patents
Traditional Chinese medicine combination for curing stomach cancer, and preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to the field of Chinese herba preparations, in particular to a traditional Chinese medicine combination for curing stomach cancer, and a preparation method and the application thereof. The combination comprises the following crude drugs in parts by weight: 8 parts of sculellaria barbata, 6 parts of herba patriniae, 7 parts of cyperus rotundus, 3 parts of toad, 8 parts of cuttle bone, 3 parts of centipede, 12 parts of bighead atractylodes rhizome, 10 parts of rhizoma atractylodis, 7 parts of dangshen, 6 parts of atragalus membranaceus, 6 parts of liquorice, 10 parts of roots of kudzu vine, 6 parts of fiveleaf gynostemma herb, 5 parts of sticktight, 10 parts of radix achyranthis bidentatae, and 6 parts of common bletilla tuber. The traditional Chinese medicine combination has a good curative effect for curing stomach cancer, and is high in cure rate and low in recurrence rate.
Description
Technical field
The present invention relates to field of traditional Chinese, particularly a kind of Chinese medicine composition being used for the treatment of gastric cancer and preparation method thereof and application.
Background technology
Gastric cancer ranks first in the various malignant tumor of China, and incidence gastric cancer has obvious region difference, is evident as height in the northwest of China and coastal region in east China incidence gastric cancer rate than southern area.Send out well the age more than 50 years old, the ratio of men and women's sickness rate is 2:1.The most patient's non-evident sympton of early gastric cancer, a few peoples have the digestive symptoms of Nausea and vomiting or similar Peptic Ulcers.Pain is the modal clinical symptoms of advanced gastric carcinoma with losing weight.Often can there is anemia, become thin in late gastric cancer patient, the malnutrition even performance such as cachexia.
Along with the more prevalent property of gastric cancer, the treatment means at present for gastric cancer is also more and more abundanter.At present, the means of conventional treatment gastric cancer comprise: operative treatment, chemotherapy, traditional Chinese medical herbal treatment, radiotherapy, thermotherapy, immunization therapy etc.The diagnosis and treatment of the traditional Chinese medical science to the gastric cancer that gastric cancer especially chronic gastropathy causes have the opinion of its uniqueness, and have obtained good curative effect and progress.The traditional Chinese medical science is started with from the macroscopic analysis cause of disease, pathogenesis, determines the attribute of chronic gastric cancer.It is generally acknowledged the spleen being the foundation of acquired constitution, source of generating QI and blood, spleen injury is deficiency of vital QI then, so that defends outer gas nowhere with life, invades, stores knot and do not remove, cause carcinoma to produce in evil poison.So the traditional Chinese medical science, according to pathogenesis and method for the treatment of, just can find corresponding side's medicine.Because the cause of disease of gastric cancer is various, pathogenesis is mixed, clinically according to the pathogenic characteristic of chronic gastric cancer, the key affecting its lesion growth should be caught, change the process of disease, thus reach the object of progressively curing.But on the dosage of Chinese medicine medication, should carefully consider, the compatibility relationship of concrete how much dosage and monarch needs long-term clinical practice.Thus it is a lot of intricate also to occur on the market, and the uneven prescription of effect, much exist the problem that onset is slow, specific aim is poor, still needs to improve or break through.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of effectively can treat gastric cancer and the little Chinese medicine composition of short treating period, side effect.
The present invention still further provides preparation method and its application of above-mentioned Chinese medicine composition.
The present invention discloses a kind of Chinese medicine composition being used for the treatment of gastric cancer, its crude drug consists of: Herba Scutellariae Barbatae 2-14 weight portion, Herba Patriniae 1-10 weight portion, Rhizoma Cyperi 2-14 weight portion, Bufo siccus 1-10 weight portion, Os Sepiae 3-14 weight portion, Scolopendra 1-10 weight portion, Rhizoma Atractylodis Macrocephalae 5-18 weight portion, Rhizoma Atractylodis 3-16 weight portion, Radix Codonopsis 1-12 weight portion, Radix Astragali 1-10 weight portion, Radix Glycyrrhizae 1-10 weight portion, Radix Puerariae 5-17 weight portion, Herb Gynostemmae Pentaphylli 1-10 weight portion, Herba Bidentis Bipinnatae 1-12 weight portion, Radix Achyranthis Bidentatae 4-18 weight portion, Pseudobulbus Bletillae (Rhizoma Bletillae) 1-12 weight portion.
Further, the described Chinese medicine composition being used for the treatment of gastric cancer, its crude drug consists of: Herba Scutellariae Barbatae 5-10 weight portion, Herba Patriniae 3-8 weight portion, Rhizoma Cyperi 5-10 weight portion, Bufo siccus 2-5 weight portion, Os Sepiae 6-10 weight portion, Scolopendra 2-6 weight portion, Rhizoma Atractylodis Macrocephalae 8-14 weight portion, Rhizoma Atractylodis 6-13 weight portion, Radix Codonopsis 3-10 weight portion, Radix Astragali 2-8 weight portion, Radix Glycyrrhizae 2-8 weight portion, Radix Puerariae 8-14 weight portion, Herb Gynostemmae Pentaphylli 3-9 weight portion, Herba Bidentis Bipinnatae 2-8 weight portion, Radix Achyranthis Bidentatae 8-14 weight portion, Pseudobulbus Bletillae (Rhizoma Bletillae) 3-9 weight portion.
Preferably, the described Chinese medicine composition being used for the treatment of gastric cancer, its crude drug consists of: Herba Scutellariae Barbatae 8 weight portion, Herba Patriniae 6 weight portion, Rhizoma Cyperi 7 weight portion, Bufo siccus 3 weight portion, Os Sepiae 8 weight portion, Scolopendra 3 weight portion, the Rhizoma Atractylodis Macrocephalae 12 weight portion, Rhizoma Atractylodis 10 weight portion, Radix Codonopsis 7 weight portion, the Radix Astragali 6 weight portion, Radix Glycyrrhizae 6 weight portion, Radix Puerariae 10 weight portion, Herb Gynostemmae Pentaphylli 6 weight portion, Herba Bidentis Bipinnatae 5 weight portion, Radix Achyranthis Bidentatae 10 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 6 weight portion.
The invention also discloses and add customary adjuvant by arbitrary described Chinese medicine composition selectivity being used for the treatment of gastric cancer, conveniently the acceptable clinically preparation made of technique.
Further described preparation, comprises electuary, powder, tablet, granule, capsule, mixture, pill, injection or drop pill.
The invention also discloses a kind of method preparing arbitrary described Chinese medicine composition: get Herba Scutellariae Barbatae, Herba Patriniae, Rhizoma Cyperi according to selected weight portion, Bufo siccus, Os Sepiae, Scolopendra, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Radix Codonopsis, the Radix Astragali, Radix Glycyrrhizae, Radix Puerariae, Herb Gynostemmae Pentaphylli, Herba Bidentis Bipinnatae, Radix Achyranthis Bidentatae and the Pseudobulbus Bletillae (Rhizoma Bletillae), selectivity adds customary adjuvant, conveniently technique, makes acceptable preparation clinically.
Further, described preparation method, comprises the steps:
According to selected parts by weight Herba Scutellariae Barbatae, Herba Patriniae, Rhizoma Cyperi, Bufo siccus, Os Sepiae, Scolopendra, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Radix Codonopsis, the Radix Astragali, Radix Glycyrrhizae, Radix Puerariae, Herb Gynostemmae Pentaphylli, Herba Bidentis Bipinnatae, Radix Achyranthis Bidentatae and the Pseudobulbus Bletillae (Rhizoma Bletillae), remix after pulverizing or pulverizing respectively, sieve after mixing, and selectivity adds customary adjuvant, conveniently technique, makes acceptable preparation clinically.
More excellent, described preparation method, comprises the steps:
Herba Scutellariae Barbatae is got, Herba Patriniae, Rhizoma Cyperi, Bufo siccus, Os Sepiae, Scolopendra, the Rhizoma Atractylodis Macrocephalae according to selected parts by weight, Rhizoma Atractylodis, Radix Codonopsis, the Radix Astragali, Radix Glycyrrhizae, Radix Puerariae, Herb Gynostemmae Pentaphylli, Herba Bidentis Bipinnatae, Radix Achyranthis Bidentatae and the Pseudobulbus Bletillae (Rhizoma Bletillae), mixing, extracting in water, filters and collects filtrate, obtaining concentrated solution after concentrating under reduced pressure; Above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation; Or
Herba Scutellariae Barbatae is got, Herba Patriniae, Rhizoma Cyperi, Bufo siccus, Os Sepiae, Scolopendra, the Rhizoma Atractylodis Macrocephalae according to selected parts by weight, Rhizoma Atractylodis, Radix Codonopsis, the Radix Astragali, Radix Glycyrrhizae, Radix Puerariae, Herb Gynostemmae Pentaphylli, Herba Bidentis Bipinnatae, Radix Achyranthis Bidentatae and the Pseudobulbus Bletillae (Rhizoma Bletillae), mixing, adds ethanol extraction, filters and collect filtrate, obtaining concentrated solution after concentrating under reduced pressure; Above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation.
Preferred further, described preparation method, comprises the steps:
(1) get wherein one or more raw material components mixing according to selected parts by weight, add alcohol reflux, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) again according to raw material components mixing under selected parts by weight remainder, direct extracting in water, or mix extracting in water again with the medicinal residues after alcohol extraction in step (1), filter and collect filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation.
The invention also discloses Chinese medicine composition that arbitrary described Chinese medicine composition or arbitrary described method prepare for the preparation of the purposes in treatment gastric cancer medicament.
In Chinese medicine composition of the present invention, Herba Scutellariae Barbatae: property is pungent, flat, there is heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, anticancer effect; Appendicitis curing, hepatitis, gastric cancer, early hepatocarcinoma, pulmonary carcinoma, cervical cancer, mastitis etc.Herba Patriniae: cool in nature, acrid in the mouth, hardship, heat-clearing and toxic substances removing, removing blood stasis and expelling pus, controls gastric acid, and has strong antitumaous effect.Rhizoma Cyperi: sweet in the mouth, is slightly cold, nontoxic, for gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation, vomiting and nausea, dyspepsia.Bufo siccus: acrid in the mouth, cold in nature, micro-poison, has the effects such as removing toxic substances, anticancer, detumescence, pain relieving, heart tonifying diuresis, anesthesia, radioprotective.Os Sepiae: salty in the mouth, puckery, warm in nature, returns spleen, kidney channel, astringing to arrest bleeding, relieving gastric hyperacidity to alleviate stomachache, and for Peptic Ulcers, hyperchlorhydria, treatment taste-blindness rate and hemorrhage etc., has the effects such as radioprotective, antitumor, antiulcer.Scolopendra: relieve internal heat anticancer, can be used for the long-pending poison of carcinoma, can control gastric cancer, the esophageal carcinoma, pulmonary carcinoma, hepatocarcinoma etc.The Rhizoma Atractylodis Macrocephalae: bitter in the mouth, sweet, warm in nature, returns spleen, stomach warp, invigorating the spleen and benefiting QI, dampness diuretic, for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement, and there is antitumor action, Rhizoma Atractylodis Macrocephalae extract has remarkable inhibition to animal water-immersion restraint stress ulcer.Rhizoma Atractylodis: property is pungent, bitter, temperature, returns spleen, stomach, Liver Channel, has adjustment gastrointestinal motility function, stronger antiulcer action, can gastric acid secretion inhibiting, strengthens gastric mucosal protective effect, also has antineoplastic effect.Radix Codonopsis: property is put down, sweet in the mouth, has the effect of invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, anticancer, blood pressure lowering, anti-hypoxia, defying age, Gastrointestinal motility adjustment, antiulcer, gastric acid secretion inhibiting, reduction pepsin activity.The Radix Astragali: property is sweet, tepor, have in enhancing human body immunity function, anti-stress, fill temperature, the effect of relieving spasm to stop pain, can be used for Deficiency and coldness of spleen and stomach, stomachache contracture, cardiopalmus spontaneous perspiration, and for stomach, 12 fat ulcer, gastrointestinal dysfunction.Radix Glycyrrhizae: property is sweet, flat, GUIXIN, spleen, lung, stomach warp, can be used for deficiency of spleen-QI and stomach-QI, fatigue and weakness, stomachache, stomachache and the anxious pain of gastrocnemius contraction etc.Radix Puerariae: cool in nature, sweet in the mouth is pungent, has the differentiation of anti-promoting and inducing cancer cell, also has effects such as growing body is healthy and strong, defying age, blood pressure lowering, blood sugar lowering, blood fat reducing.Herb Gynostemmae Pentaphylli: bitter in the mouth, micro-sweet, cool in nature, cure mainly body void weak, chronic gastroenteritis, nephrasthenia emission, leukopenia etc.Herba Bidentis Bipinnatae: property is bitter, flat, cures mainly gastroenteritis, upper respiratory tract infection, laryngopharynx swelling and pain, acute appendicitis, acute icterohepatitis, Fengshi Guanjie pain, malaria.Radix Achyranthis Bidentatae: sweet in the mouth, picric acid, property is put down, and has the effect of anti-inflammatory and antalgic.The Pseudobulbus Bletillae (Rhizoma Bletillae): bitter in the mouth, sweet, puckery, cold in nature, returns lung, liver, stomach warp, has astringing to arrest bleeding, the merit of detumescence and promoting granulation, can control stomach, pneumorrhagia.
Pharmaceutical composition of the present invention with Herba Scutellariae Barbatae, Herba Patriniae, Rhizoma Cyperi, Bufo siccus, Os Sepiae, Scolopendra, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Radix Codonopsis, the Radix Astragali, Radix Glycyrrhizae, Radix Puerariae, Herb Gynostemmae Pentaphylli, Herba Bidentis Bipinnatae, Radix Achyranthis Bidentatae and the Pseudobulbus Bletillae (Rhizoma Bletillae) are used as medicine, its heat-clearing and toxic substances removing of row, effect of blood circulation promoting and blood stasis dispelling, is aided with the antitumaous effect that raw material has, by the effective cooperation between monarch, have good curative effect to treatment gastric cancer, clinical cure rate is up to 98%.
Detailed description of the invention
Embodiment 1
The crude drug being used for the treatment of the Chinese medicine composition of gastric cancer of the present embodiment consists of: Herba Scutellariae Barbatae 8 weight portion, Herba Patriniae 6 weight portion, Rhizoma Cyperi 7 weight portion, Bufo siccus 3 weight portion, Os Sepiae 8 weight portion, Scolopendra 3 weight portion, the Rhizoma Atractylodis Macrocephalae 12 weight portion, Rhizoma Atractylodis 10 weight portion, Radix Codonopsis 7 weight portion, the Radix Astragali 6 weight portion, Radix Glycyrrhizae 6 weight portion, Radix Puerariae 10 weight portion, Herb Gynostemmae Pentaphylli 6 weight portion, Herba Bidentis Bipinnatae 5 weight portion, Radix Achyranthis Bidentatae 10 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 6 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make pill.Specifically comprise:
Herba Scutellariae Barbatae is got, Herba Patriniae, Rhizoma Cyperi, Bufo siccus according to selected parts by weight, Os Sepiae, Scolopendra, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Radix Codonopsis, the Radix Astragali, Radix Glycyrrhizae, Radix Puerariae, Herb Gynostemmae Pentaphylli, Herba Bidentis Bipinnatae, Radix Achyranthis Bidentatae and the Pseudobulbus Bletillae (Rhizoma Bletillae), pulverize respectively, cross 100 mesh sieves, mixing, adds appropriate water according to every 100g powder refined honey 20 ~ 50g, pill, dry, make water-honeyed pill; Or add refined honey 80 ~ 110g and make small honey pill or big honeyed pills, to obtain final product.
Embodiment 2
The crude drug being used for the treatment of the Chinese medicine composition of gastric cancer of the present embodiment consists of: Herba Scutellariae Barbatae 2 weight portion, Herba Patriniae 1 weight portion, Rhizoma Cyperi 2 weight portion, Bufo siccus 1 weight portion, Os Sepiae 3 weight portion, Scolopendra 1 weight portion, the Rhizoma Atractylodis Macrocephalae 5 weight portion, Rhizoma Atractylodis 3 weight portion, Radix Codonopsis 1 weight portion, the Radix Astragali 1 weight portion, Radix Glycyrrhizae 1 weight portion, Radix Puerariae 5 weight portion, Herb Gynostemmae Pentaphylli 1 weight portion, Herba Bidentis Bipinnatae 1 weight portion, Radix Achyranthis Bidentatae 4 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 1 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make tablet.Specifically comprise:
(1) Herba Scutellariae Barbatae is got, Herba Patriniae, Rhizoma Cyperi, Bufo siccus according to selected parts by weight, Os Sepiae, Scolopendra, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Radix Codonopsis, the Radix Astragali, Radix Glycyrrhizae, Radix Puerariae, Herb Gynostemmae Pentaphylli, Herba Bidentis Bipinnatae, Radix Achyranthis Bidentatae and the Pseudobulbus Bletillae (Rhizoma Bletillae), mixing, by the water reflux, extract, of 10 volume times amount, reflux, extract, 2 times under maintenance temperature 60 C, each 3h, filters and collects filtrate, obtaining aqueous extract;
(2) aqueous extract obtained in step (1) being evaporated to relative density is 1.05-1.30 (40 ~ 60 DEG C), obtains concentrated solution;
(3) by above-mentioned concentrated solution vacuum drying, pulverize, sieve, obtain dry extract, add customary adjuvant, conveniently technique, make tablet.
Embodiment 3
The crude drug being used for the treatment of the Chinese medicine composition of gastric cancer of the present embodiment consists of: Herba Scutellariae Barbatae 5 weight portion, Herba Patriniae 3 weight portion, Rhizoma Cyperi 5 weight portion, Bufo siccus 2 weight portion, Os Sepiae 6 weight portion, Scolopendra 2 weight portion, the Rhizoma Atractylodis Macrocephalae 8 weight portion, Rhizoma Atractylodis 6 weight portion, Radix Codonopsis 3 weight portion, the Radix Astragali 2 weight portion, Radix Glycyrrhizae 2 weight portion, Radix Puerariae 8 weight portion, Herb Gynostemmae Pentaphylli 3 weight portion, Herba Bidentis Bipinnatae 2 weight portion, Radix Achyranthis Bidentatae 8 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 3 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make powder.Specifically comprise:
(1) Herba Scutellariae Barbatae is got, Herba Patriniae, Rhizoma Cyperi, Bufo siccus according to selected parts by weight, Os Sepiae, Scolopendra, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Radix Codonopsis, the Radix Astragali, Radix Glycyrrhizae, Radix Puerariae, Herb Gynostemmae Pentaphylli, Herba Bidentis Bipinnatae, Radix Achyranthis Bidentatae and the Pseudobulbus Bletillae (Rhizoma Bletillae), mixing, with 75% alcohol reflux of 8 volume times amount, reflux, extract, 3 times at maintenance temperature 80 DEG C, each 1.5h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) the alcohol extract concentrating under reduced pressure will obtained in step (1), obtains concentrated solution;
(3) be 1.05-1.30 (40 ~ 60 DEG C) by above-mentioned concentrated solution vacuum drying relative density, pulverize, sieve, obtain dry extract, add customary adjuvant, conveniently technique, make powder.
Embodiment 4
The crude drug being used for the treatment of the Chinese medicine composition of gastric cancer of the present embodiment consists of: Herba Scutellariae Barbatae 10 weight portion, Herba Patriniae 8 weight portion, Rhizoma Cyperi 10 weight portion, Bufo siccus 5 weight portion, Os Sepiae 10 weight portion, Scolopendra 6 weight portion, the Rhizoma Atractylodis Macrocephalae 14 weight portion, Rhizoma Atractylodis 13 weight portion, Radix Codonopsis 10 weight portion, the Radix Astragali 8 weight portion, Radix Glycyrrhizae 8 weight portion, Radix Puerariae 14 weight portion, Herb Gynostemmae Pentaphylli 9 weight portion, Herba Bidentis Bipinnatae 8 weight portion, Radix Achyranthis Bidentatae 14 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 9 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make granule.Specifically comprise:
(1) Herba Scutellariae Barbatae is got, Herba Patriniae, Rhizoma Cyperi, Bufo siccus according to selected parts by weight, Os Sepiae, Scolopendra, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Radix Codonopsis, the Radix Astragali, Radix Glycyrrhizae, Radix Puerariae, Herb Gynostemmae Pentaphylli, Herba Bidentis Bipinnatae, Radix Achyranthis Bidentatae and the Pseudobulbus Bletillae (Rhizoma Bletillae), mixing, with 90% alcohol reflux of 4 volume times amount, reflux, extract, 3 times under maintenance temperature 70 C, each 1.5h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) in the medicinal residues after the alcohol extraction in step (1), add the water extraction 2 times of 15 volume times amount again, each 2h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, 60 DEG C of concentrating under reduced pressure, obtain concentrated solution;
(4) fluidized bed granulation is carried out with the concentrated solution obtained in step (3), be that the dextrin of 30 ~ 75% is for fluidisation carrier to account for described concentrated solution mass ratio, with account for described concentrated solution mass ratio be 1 ~ 5% traditional binders granulate, control that its feed liquor flow velocity is 2.5ml/min, fluidized pressure is 0.2 ~ 0.5bar, atomizing pressure is 1.0 ~ 1.8bar, temperature 55 DEG C, granulate, and increase gradually along with particle in fluid bed, adjustment fluidized pressure and atomizing pressure, keep the fluidized state of material good, temperature of charge remains between 35 ~ 37 DEG C.After feed liquor terminates, continue fluidized drying 1 hour, obtain granule.
Embodiment 5
The crude drug being used for the treatment of the Chinese medicine composition of gastric cancer of the present embodiment consists of: Herba Scutellariae Barbatae 14 weight portion, Herba Patriniae 10 weight portion, Rhizoma Cyperi 14 weight portion, Bufo siccus 10 weight portion, Os Sepiae 14 weight portion, Scolopendra 10 weight portion, the Rhizoma Atractylodis Macrocephalae 18 weight portion, Rhizoma Atractylodis 16 weight portion, Radix Codonopsis 12 weight portion, the Radix Astragali 10 weight portion, Radix Glycyrrhizae 10 weight portion, Radix Puerariae 17 weight portion, Herb Gynostemmae Pentaphylli 10 weight portion, Herba Bidentis Bipinnatae 12 weight portion, Radix Achyranthis Bidentatae 18 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 12 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make capsule.Specifically comprise:
(1) get it filled according to selected parts by weight, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, pull out chinaroot greenbrier, Semen Cucurbitae, Cortex Lycii, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati, Radix Rehmanniae Preparata, stone square rafter, wild mint, Poria and Rhizoma Alismatis, mixing, with 50% alcohol reflux of 6 volume times amount, reflux, extract, 3 times at maintenance temperature 80 DEG C, each 2h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) in the medicinal residues after the alcohol extraction in step (1), add the water extraction 1 time of 10 volume times amount again, 2h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) by above-mentioned concentrated solution vacuum drying, pulverize, sieve, obtain dry extract, directly encapsulated or encapsulated after adding customary adjuvant mix homogeneously, to obtain final product.
Embodiment 6
The crude drug being used for the treatment of the Chinese medicine composition of gastric cancer of the present embodiment consists of: Herba Scutellariae Barbatae 2 weight portion, Herba Patriniae 10 weight portion, Rhizoma Cyperi 2 weight portion, Bufo siccus 10 weight portion, Os Sepiae 3 weight portion, Scolopendra 10 weight portion, the Rhizoma Atractylodis Macrocephalae 5 weight portion, Rhizoma Atractylodis 16 weight portion, Radix Codonopsis 1 weight portion, the Radix Astragali 10 weight portion, Radix Glycyrrhizae 1 weight portion, Radix Puerariae 17 weight portion, Herb Gynostemmae Pentaphylli 1 weight portion, Herba Bidentis Bipinnatae 12 weight portion, Radix Achyranthis Bidentatae 4 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 12 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make mixture.Specifically comprise:
(1) Herba Scutellariae Barbatae is got, Herba Patriniae, Rhizoma Cyperi, Bufo siccus according to selected parts by weight, Os Sepiae, Scolopendra, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Radix Codonopsis, the Radix Astragali, Radix Glycyrrhizae, Radix Puerariae, Herb Gynostemmae Pentaphylli, Herba Bidentis Bipinnatae, Radix Achyranthis Bidentatae and the Pseudobulbus Bletillae (Rhizoma Bletillae), mixing, with 70% alcohol reflux of 12 volume times amount, reflux, extract, 3 times under maintenance temperature 70 C, each 1.5h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) in the medicinal residues after the alcohol extraction in step (1), add the water extraction 2 times of 10 volume times amount again, each 2h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) by above-mentioned concentrated solution cold preservation 24 hours, filter, filtrate is boiled, and it is appropriate to add customary adjuvant, makes dissolving, filters, let cool, add water to 1000ml, stir evenly, embedding, sterilizing, namely obtains required mixture.
Embodiment 7
The crude drug being used for the treatment of the Chinese medicine composition of gastric cancer of the present embodiment consists of: Herba Scutellariae Barbatae 4 weight portion, Herba Patriniae 9 weight portion, Rhizoma Cyperi 12 weight portion, Bufo siccus 8 weight portion, Os Sepiae 12 weight portion, Scolopendra 8 weight portion, the Rhizoma Atractylodis Macrocephalae 7 weight portion, Rhizoma Atractylodis 14 weight portion, Radix Codonopsis 11 weight portion, the Radix Astragali 9 weight portion, Radix Glycyrrhizae 9 weight portion, Radix Puerariae 7 weight portion, Herb Gynostemmae Pentaphylli 2 weight portion, Herba Bidentis Bipinnatae 9 weight portion, Radix Achyranthis Bidentatae 15 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make drop pill.Specifically comprise:
(1) Herba Scutellariae Barbatae is got, Herba Patriniae, Rhizoma Cyperi according to selected parts by weight, Bufo siccus, Os Sepiae, Radix Achyranthis Bidentatae and the Pseudobulbus Bletillae (Rhizoma Bletillae), mixing, with 90% alcohol reflux of 10 volume times amount, reflux, extract, 3 times at maintenance temperature 78 DEG C, each 4h, filters and collects filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) Scolopendra is got, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Radix Codonopsis, the Radix Astragali according to selected parts by weight, Radix Glycyrrhizae, Radix Puerariae, Herb Gynostemmae Pentaphylli, Herba Bidentis Bipinnatae, mixing, by the water reflux, extract, of 7 volume times amount, reflux, extract, 2 times under maintenance temperature 60 C, each 1h, filters and collects filtrate, obtaining aqueous extract; (please applicant confirm according to above-mentioned steps crude drug order of addition successively whether can)
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) above-mentioned concentrated solution is added customary adjuvant, conveniently technique, make drop pill.
Embodiment 8
The crude drug being used for the treatment of the Chinese medicine composition of gastric cancer of the present embodiment consists of: Herba Scutellariae Barbatae 14 weight portion, Herba Patriniae 1 weight portion, Rhizoma Cyperi 14 weight portion, Bufo siccus 1 weight portion, Os Sepiae 14 weight portion, Scolopendra 1 weight portion, the Rhizoma Atractylodis Macrocephalae 18 weight portion, Rhizoma Atractylodis 3 weight portion, Radix Codonopsis 12 weight portion, the Radix Astragali 1 weight portion, Radix Glycyrrhizae 10 weight portion, Radix Puerariae 5 weight portion, Herb Gynostemmae Pentaphylli 106 weight portion, Herba Bidentis Bipinnatae 1 weight portion, Radix Achyranthis Bidentatae 18 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 1 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make injection.Specifically comprise:
(1) Herba Scutellariae Barbatae is got, Herba Patriniae, Rhizoma Cyperi according to selected parts by weight, Bufo siccus, Os Sepiae, Radix Achyranthis Bidentatae and the Pseudobulbus Bletillae (Rhizoma Bletillae), mixing, with 70% alcohol reflux of 12 volume times amount, reflux, extract, 3 times under maintenance temperature 70 C, each 1.5h, filters and collects filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) Scolopendra is got, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Radix Codonopsis, the Radix Astragali according to selected parts by weight, Radix Glycyrrhizae, Radix Puerariae, Herb Gynostemmae Pentaphylli, Herba Bidentis Bipinnatae, mixing, by the water reflux, extract, of 10 volume times amount, reflux, extract, 2 times under maintenance temperature 60 C, each 3h, filters and collects filtrate, obtaining aqueous extract; (please applicant confirm according to above-mentioned steps crude drug order of addition successively whether can)
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) filtered by above-mentioned concentrated solution, dilution, adjust ph, adds customary adjuvant, conveniently technique, makes injection.
Embodiment 9
The crude drug being used for the treatment of the Chinese medicine composition of gastric cancer of the present embodiment consists of: Herba Scutellariae Barbatae 5 weight portion, Herba Patriniae 8 weight portion, Rhizoma Cyperi 5 weight portion, Bufo siccus 5 weight portion, Os Sepiae 6 weight portion, Scolopendra 6 weight portion, the Rhizoma Atractylodis Macrocephalae 812 weight portion, Rhizoma Atractylodis 13 weight portion, Radix Codonopsis 3 weight portion, the Radix Astragali 8 weight portion, Radix Glycyrrhizae 2 weight portion, Radix Puerariae 14 weight portion, Herb Gynostemmae Pentaphylli 3 weight portion, Herba Bidentis Bipinnatae 8 weight portion, Radix Achyranthis Bidentatae 8 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 9 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make powder.Specifically comprise:
(1) get it filled according to selected parts by weight, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, pull out chinaroot greenbrier, Semen Cucurbitae, Cortex Lycii, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati, Radix Rehmanniae Preparata, stone square rafter, wild mint, Poria and Rhizoma Alismatis, mixing, with 78% alcohol reflux of 12 volume times amount, reflux, extract, 3 times at maintenance temperature 85 DEG C, each 6h, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) in the medicinal residues after the alcohol extraction in step (1), add the water extraction 2 times of 9 volume times amount again, each 3h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) above-mentioned concentrated solution is added customary adjuvant, conveniently technique, make powder.
Embodiment 10
The crude drug being used for the treatment of the Chinese medicine composition of gastric cancer of the present embodiment consists of: Herba Scutellariae Barbatae 10 weight portion, Herba Patriniae 3 weight portion, Rhizoma Cyperi 10 weight portion, Bufo siccus 2 weight portion, Os Sepiae 10 weight portion, Scolopendra 2 weight portion, the Rhizoma Atractylodis Macrocephalae 14 weight portion, Rhizoma Atractylodis 6 weight portion, Radix Codonopsis 10 weight portion, the Radix Astragali 2 weight portion, Radix Glycyrrhizae 8 weight portion, Radix Puerariae 8 weight portion, Herb Gynostemmae Pentaphylli 9 weight portion, Herba Bidentis Bipinnatae 2 weight portion, Radix Achyranthis Bidentatae 14 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 3 weight portion.
Get above-mentioned raw materials medicine component according to selected weight portion, add customary adjuvant, conveniently technique, make electuary.Specifically comprise:
(1) get it filled according to selected parts by weight, Fructus Momordicae charantiae, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, pull out chinaroot greenbrier, Semen Cucurbitae, Cortex Lycii, Fructus Crataegi, Rhizoma Polygoni Cuspidati, Bombyx Batryticatus, Rhizoma Polygonati, Radix Rehmanniae Preparata, stone square rafter, wild mint, Poria and Rhizoma Alismatis, mixing, with 70% alcohol reflux of 10 volume times amount, reflux, extract, 2 times at maintenance temperature 85 DEG C, each 2h, filter and collect filtrate, less than 60 DEG C decompression recycling ethanols, to without alcohol taste, obtain alcohol extract;
(2) in the medicinal residues after the alcohol extraction in step (1), add the water extraction 3 times of 10 volume times amount again, each 1.5h, filters and collects filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) above-mentioned concentrated solution is added customary adjuvant, conveniently technique, make electuary.
Clinical experiment example
Getting the preparation prepared in embodiments of the invention 1 is the elaboration that example carries out effect, clinical take for honeyed pill, oral, every day 2 times, each serving with 8 ~ 10g, 300 routine stomach cancer patients are treated, take 50-200 days continuously.Cure 294 examples, clinical effective 300 examples, invalid 0 example, overall cure rate reaches 98%.Follow-up Continuous Tracking follows up a case by regular visits to 24 months, without recurrence.
Model case
Case one
Zhou Baoliang, Fuzhou City, Fujian Province, 62 years old, man.Get a cancer of the stomach and did operation recurrence in 10 months, seek medical advice always and there is no effect.Trial edition Chinese medicine composition 20 is secondary, eats up first about 10 days, and the sensation such as lump, belly feeling of distension and oppression, pain alleviates to some extent, then after adhering to having eaten 50 days, all very normal through examination in hospital health indices, lump disappears entirely, distending pain sense is all good.Call-on back by phone after spending 2 years, health is fine, and body weight increases 3-4 jin.
Case two
Reputation man spring, Fujian, 59 years old, man.Get a cancer of the stomach and did operation recurrence in 3 months, lymphonodi cervicales plethora, seeks medical advice always and does not have effect.Trial edition Chinese medicine composition 30 is secondary, eats up first about 15 days, anti-loose, the lymph node plethora of gastric cancer all take a favorable turn, and increases of having a meal, body constitution are got well a lot.After adhering to having eaten 50 days again, all very normal through examination in hospital health indices, anti-loose, the lymph node plethora of gastric cancer all disappears.Call-on back by phone after spending 1 year, health is fine.
Case three
Chen Jianqiang, Fujian, 58 years old, man.Get a cancer of the stomach and 3 years, to do operation recurrence after 10 months more, seek medical advice always take traditional Chinese medicine, Western medicine all do not take a turn for the better.Trial edition Chinese medicine composition 15 is secondary.After eating first 10 days, belly distending pain, turn reducing all to some extent uncomfortable in chest.Adhere to 60 days again, gastric cancer is anti-loose, and belly distending pain all recovers normal.Call-on back by phone after spending 1 year, health gun-ho.
Case four
Zhu Huiwen, Shangrao, Jiangxi, 56 years old, man.Get a cancer of the stomach and 3 years, to do Post operation recurrence in 7 months more, seek medical advice always take traditional Chinese medicine, Western medicine all do not take a turn for the better.Trial edition Chinese medicine composition has first eaten 15 days, has that about 7 days belly distending pains are uncomfortable in chest to be alleviated all to some extent.After adhering to having eaten 160 days again, good through all indexs of examination in hospital.Call-on back by phone after spending 1 year, health gun-ho.
Case five
Cheng Jianliang, Yongjia city, 59 years old, man.Get a cancer of the stomach and 3 years, to do Post operation recurrence in 5 months more, seek medical advice always take traditional Chinese medicine, Western medicine all do not take a turn for the better.Trial edition Chinese medicine composition 15 is secondary, and after having the 10th day, belly distending pain, uncomfortable in chest etc. alleviates all to some extent.Adhere to again eating 60 days, through examination in hospital gun-ho.Call-on back by phone after spending 1 year, health gun-ho.
Be more than concrete case, when proving that Chinese medicine composition of the present invention is used for the treatment of gastric cancer by the multinomial case of reality, good effect, cure rate are up to 98%, and relapse rate is low.It should be noted that, Chinese medicine composition of the present invention all has good therapeutic effect for the gastric cancer of each degree, and cure rate is higher.
Obviously, above-described embodiment is only for clearly example being described, and the restriction not to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without the need to also giving all embodiments.And thus the apparent change of extending out or variation be still among the protection domain of the invention.
Claims (10)
1. one kind is used for the treatment of the Chinese medicine composition of gastric cancer, it is characterized in that, the crude drug of said composition consists of: Herba Scutellariae Barbatae 2-14 weight portion, Herba Patriniae 1-10 weight portion, Rhizoma Cyperi 2-14 weight portion, Bufo siccus 1-10 weight portion, Os Sepiae 3-14 weight portion, Scolopendra 1-10 weight portion, Rhizoma Atractylodis Macrocephalae 5-18 weight portion, Rhizoma Atractylodis 3-16 weight portion, Radix Codonopsis 1-12 weight portion, Radix Astragali 1-10 weight portion, Radix Glycyrrhizae 1-10 weight portion, Radix Puerariae 5-17 weight portion, Herb Gynostemmae Pentaphylli 1-10 weight portion, Herba Bidentis Bipinnatae 1-12 weight portion, Radix Achyranthis Bidentatae 4-18 weight portion, Pseudobulbus Bletillae (Rhizoma Bletillae) 1-12 weight portion.
2. be used for the treatment of the Chinese medicine composition of gastric cancer as claimed in claim 1, it is characterized in that, the crude drug of said composition consists of: Herba Scutellariae Barbatae 5-10 weight portion, Herba Patriniae 3-8 weight portion, Rhizoma Cyperi 5-10 weight portion, Bufo siccus 2-5 weight portion, Os Sepiae 6-10 weight portion, Scolopendra 2-6 weight portion, Rhizoma Atractylodis Macrocephalae 8-14 weight portion, Rhizoma Atractylodis 6-13 weight portion, Radix Codonopsis 3-10 weight portion, Radix Astragali 2-8 weight portion, Radix Glycyrrhizae 2-8 weight portion, Radix Puerariae 8-14 weight portion, Herb Gynostemmae Pentaphylli 3-9 weight portion, Herba Bidentis Bipinnatae 2-8 weight portion, Radix Achyranthis Bidentatae 8-14 weight portion, Pseudobulbus Bletillae (Rhizoma Bletillae) 3-9 weight portion.
3. be used for the treatment of the Chinese medicine composition of gastric cancer as claimed in claim 1 or 2, it is characterized in that, the crude drug of said composition consists of: Herba Scutellariae Barbatae 8 weight portion, Herba Patriniae 6 weight portion, Rhizoma Cyperi 7 weight portion, Bufo siccus 3 weight portion, Os Sepiae 8 weight portion, Scolopendra 3 weight portion, the Rhizoma Atractylodis Macrocephalae 12 weight portion, Rhizoma Atractylodis 10 weight portion, Radix Codonopsis 7 weight portion, the Radix Astragali 6 weight portion, Radix Glycyrrhizae 6 weight portion, Radix Puerariae 10 weight portion, Herb Gynostemmae Pentaphylli 6 weight portion, Herba Bidentis Bipinnatae 5 weight portion, Radix Achyranthis Bidentatae 10 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 6 weight portion.
4. add customary adjuvant by the arbitrary described Chinese medicine composition selectivity being used for the treatment of gastric cancer of claim 1-3, conveniently the acceptable clinically preparation made of technique.
5. preparation as claimed in claim 4, is characterized in that, comprise electuary, powder, tablet, granule, capsule, mixture, pill, injection or drop pill.
6. prepare a method for the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that: get Herba Scutellariae Barbatae, Herba Patriniae, Rhizoma Cyperi according to selected weight portion, Bufo siccus, Os Sepiae, Scolopendra, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Radix Codonopsis, the Radix Astragali, Radix Glycyrrhizae, Radix Puerariae, Herb Gynostemmae Pentaphylli, Herba Bidentis Bipinnatae, Radix Achyranthis Bidentatae and the Pseudobulbus Bletillae (Rhizoma Bletillae), selectivity adds customary adjuvant, conveniently technique, makes acceptable preparation clinically.
7. preparation method as claimed in claim 6, is characterized in that, comprise the steps:
According to selected parts by weight Herba Scutellariae Barbatae, Herba Patriniae, Rhizoma Cyperi, Bufo siccus, Os Sepiae, Scolopendra, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Radix Codonopsis, the Radix Astragali, Radix Glycyrrhizae, Radix Puerariae, Herb Gynostemmae Pentaphylli, Herba Bidentis Bipinnatae, Radix Achyranthis Bidentatae and the Pseudobulbus Bletillae (Rhizoma Bletillae), remix after pulverizing or pulverizing respectively, sieve after mixing, and selectivity adds customary adjuvant, conveniently technique, makes acceptable preparation clinically.
8. preparation method as claimed in claim 6, is characterized in that, comprise the steps:
Herba Scutellariae Barbatae is got, Herba Patriniae, Rhizoma Cyperi, Bufo siccus, Os Sepiae, Scolopendra, the Rhizoma Atractylodis Macrocephalae according to selected parts by weight, Rhizoma Atractylodis, Radix Codonopsis, the Radix Astragali, Radix Glycyrrhizae, Radix Puerariae, Herb Gynostemmae Pentaphylli, Herba Bidentis Bipinnatae, Radix Achyranthis Bidentatae and the Pseudobulbus Bletillae (Rhizoma Bletillae), mixing, extracting in water, filters and collects filtrate, obtaining concentrated solution after concentrating under reduced pressure; Above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation; Or
Herba Scutellariae Barbatae is got, Herba Patriniae, Rhizoma Cyperi, Bufo siccus, Os Sepiae, Scolopendra, the Rhizoma Atractylodis Macrocephalae according to selected parts by weight, Rhizoma Atractylodis, Radix Codonopsis, the Radix Astragali, Radix Glycyrrhizae, Radix Puerariae, Herb Gynostemmae Pentaphylli, Herba Bidentis Bipinnatae, Radix Achyranthis Bidentatae and the Pseudobulbus Bletillae (Rhizoma Bletillae), mixing, adds ethanol extraction, filters and collect filtrate, obtaining concentrated solution after concentrating under reduced pressure; Above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation.
9. preparation method as claimed in claim 6, is characterized in that, comprise the steps:
(1) get wherein one or more raw material components mixing according to selected parts by weight, add alcohol reflux, filter and collect filtrate, decompression recycling ethanol, to without alcohol taste, obtains alcohol extract;
(2) again according to raw material components mixing under selected parts by weight remainder, direct extracting in water, or mix extracting in water again with the medicinal residues after alcohol extraction in step (1), filter and collect filtrate, obtaining aqueous extract;
(3) merged by the aqueous extract obtained in the alcohol extract obtained in step (1) and step (2) and collect, concentrating under reduced pressure, obtains concentrated solution;
(4) above-mentioned concentrated solution selectivity is added customary adjuvant, conveniently technique, make clinical acceptable preparation.
10. the Chinese medicine composition for preparing of the arbitrary described Chinese medicine composition of claim 1-3 or the arbitrary described method of claim 6-9 is for the preparation of the purposes in treatment gastric cancer medicament.
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| CN106492123A (en) * | 2016-09-21 | 2017-03-15 | 深圳市得道中医馆管理有限责任公司 | A kind of Chinese medicine composition and preparation method thereof and the application for the treatment of gastric cancer |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101708270A (en) * | 2009-12-22 | 2010-05-19 | 胡金生 | Traditional Chinese medicine composition for detoxicating and fighting cancer |
| CN103127443A (en) * | 2011-11-23 | 2013-06-05 | 周昌明 | Pharmaceutical composition for adjuvant therapy of cancers and preparation method thereof |
| CN103656461A (en) * | 2013-12-19 | 2014-03-26 | 王星月 | Traditional Chinese medicinal honeyed pill for treating gastric cancer and preparation method thereof |
-
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101708270A (en) * | 2009-12-22 | 2010-05-19 | 胡金生 | Traditional Chinese medicine composition for detoxicating and fighting cancer |
| CN103127443A (en) * | 2011-11-23 | 2013-06-05 | 周昌明 | Pharmaceutical composition for adjuvant therapy of cancers and preparation method thereof |
| CN103656461A (en) * | 2013-12-19 | 2014-03-26 | 王星月 | Traditional Chinese medicinal honeyed pill for treating gastric cancer and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106492123A (en) * | 2016-09-21 | 2017-03-15 | 深圳市得道中医馆管理有限责任公司 | A kind of Chinese medicine composition and preparation method thereof and the application for the treatment of gastric cancer |
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