CN106492123A - A kind of Chinese medicine composition and preparation method thereof and the application for the treatment of gastric cancer - Google Patents
A kind of Chinese medicine composition and preparation method thereof and the application for the treatment of gastric cancer Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/233—Bupleurum
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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Abstract
The present invention provides a kind of Chinese medicine composition, including the raw material of following weight portion：5～20 parts of Chinese fanpalm seed, 5～15 parts of Radix Bupleuri, 6～15 parts of the Radix Astragali, 8～18 parts of Fructus Camptothecae Acuminatae, 4～12 parts of Herb Gynostemmae Pentaphylli, 2～10 parts of Radix Glycyrrhizae, 3～18 parts of Rhizoma Curcumae, 1～12 part of Lentinus Edodess.Above-mentioned formula not only the experiment proved that there is good therapeutic effect to gastric cancer, and prescription is simple, cheap, and without hormone or antibiotic agents, toxic and side effects are little.The Chinese medicine composition of the present invention is prepared by liquid fermentation method, simple process, absorbing power are strong, fermentation preparation can effective the intestines and stomach coordinating, there is unique curative effect to patients with gastric cancer, the pain that patient does chemotherapy and operation can be substantially reduced, eliminate cancer to make, improve immunity of organisms, while reducing the financial burden of patient.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, is more particularly to used for the Chinese medicine composition for treating gastric cancer.
Background technology
Gastric cancer is the common malignant tumor of digestive system, is universally acknowledged persistent ailment, seriously threaten people health and
Life.And, gastric cancer is one of common malignant tumor of China, in the first place that its sickness rate Chinese occupies all kinds of tumors.Gastric cancer
Pathogenic factor is not clear, may be with many factors, such as living habit, dietetic variety, environmental factorss, heredodiathesiies, Nervous and Mental Factors etc.
Relevant, also with chronic gastritiss, polyp of stomach, gastric mucosa special-shaped hyperplasia and intestinal epithelial metaplasia, the residual stomach of Post operation, and long-term pylorus spiral shell
Bacillus infection etc. has certain relation.The Therapeutic Principle of gastric cancer is：Early discovery, early diagnosiss, early treatment, its Therapeutic Method
Have：Operative treatment, radiotherapy, chemotherapy, Chinese traditional treatment and immunization therapy.How asymptomatic early gastric cancer is or only slight disease
Shape, when clinical symptoms are obvious, pathological changes belong to late period, and because cancerous cell spreads, a lot of patients cause that sb.'s illness took a turn for the worse, and occur together
Complication, finally loses life.For a long time, because it is found that gastric cancer is later, great majority belong to late tumor, and operative effect is owed
Good, postoperative 5 years survival rates maintain 30% or so, and quality of life of patients extreme difference always.
Gastric cancer treatment by Chinese herbs is a big characteristic of China's curing gastric cancer, and as China in recent years is to treatment by Chinese herbs gastric cancer
That studied deepens continuously so that treatment by Chinese herbs plays more and more important effect in the treatment of gastric cancer.Current country's Chinese medicine
The Patents for the treatment of gastric cancer are a lot, such as Chinese medicine preparation for the treatment of gastric cancer and preparation method thereof-CN101352557A, treatment
Chinese medicine-the CN104800459A of gastric cancer, a kind of treat Chinese medicine-CN105395697A of gastric cancer etc., foregoing invention raw material type is more,
Manufacture method is simple, extensive, although have certain curative effect, but raw material availability is low, poor taste, and therefore slowly effect needs research and development one badly
Planting new Chinese medicine is used for treating gastric cancer.
Content of the invention
The technical problem to be solved in the present invention is in prior art that the Traditional Chinese medicine composition formula for treating gastric cancer is complicated, treatment
High cost, so provide that a kind of formula is simple, cheap, raw material availability is high, evident in efficacy for treating in gastric cancer
Drug composition.
For this purpose, the present invention provides a kind of Chinese medicine composition, it is characterised in that including the raw material of following weight portion：Chinese fanpalm seed 5
～20 parts, 5～15 parts of Radix Bupleuri, 6～15 parts of the Radix Astragali, 8～18 parts of Fructus Camptothecae Acuminatae, 4～12 parts of Herb Gynostemmae Pentaphylli, 2～10 parts of Radix Glycyrrhizae, Rhizoma Curcumae 3
～18 parts, 1～12 part of Lentinus Edodess.
Preferred Chinese medicine composition of the present invention, including the raw material of following weight portion：8～15 parts of Chinese fanpalm seed, Radix Bupleuri 6～12
Part, 8～12 parts of the Radix Astragali, 12～16 parts of Fructus Camptothecae Acuminatae, 8～10 parts of Herb Gynostemmae Pentaphylli, 5～8 parts of Radix Glycyrrhizae, 8～16 parts of Rhizoma Curcumae, Lentinus Edodess 3～8
Part.
Optimal Chinese medicine composition of the present invention, including the raw material of following weight portion：12 parts of Chinese fanpalm seed, 9 parts of Radix Bupleuri, the Radix Astragali 10
Part, 15 parts of Fructus Camptothecae Acuminatae, 9 parts of Herb Gynostemmae Pentaphylli, 6 parts of Radix Glycyrrhizae, 12 parts of Rhizoma Curcumae, 6 parts of Lentinus Edodess.
The Chinese medicine composition makes pharmaceutically acceptable preparation.
The preparation is any one of pill, tablet, granule, capsule, powder.
The invention further relates to the preparation method of the Chinese medicine composition, comprises the following steps：
The first step, weighs Chinese fanpalm seed, Radix Bupleuri, the Radix Astragali, Fructus Camptothecae Acuminatae, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae, Rhizoma Curcumae, Lentinus Edodess, powder by weight
Broken, sieve, mix homogeneously obtains fermentation raw material；Second step, strain is added in fermentation raw material, loads fermentation after stirring
Tank is fermented；3rd step, at 33～40 DEG C, ferments 8～12 days, and extract at low temperature at 20～60 DEG C obtains tunning；The
Four steps, add pharmaceutic adjuvant, make pharmaceutically acceptable preparation.
In second step, the strain is Mel or probiotic bacteria.
Further, the Mel is 1～2 with the part by weight of fermentation raw material：1, the probiotic bacteria and fermentation raw material
Part by weight is 0.05～0.1:1.
Further, the probiotic bacteria be lactic acid bacteria, bacillus bifiduss, one or two in yeast.
In 3rd step, at 37 DEG C, ferment 10 days, extract at low temperature at 45 DEG C obtains tunning.
The invention further relates to application of the Chinese medicine composition in treatment gastric cancer medicament is prepared.
, wherein it is desired to illustrate, for the purpose of the present invention is realized, the Chinese medicine composition of the present invention is not limited to
Above-mentioned preparation method, present invention only provides a kind of specific preparation method.
The Chinese medicine composition of the present invention, selected Chinese fanpalm seed sweet in the mouth, hardship, mild-natured, mild toxicity have hemostasis, anticancer function, main use
In metrorrhagia, traumatic hemorrhage, chorionic epithelioma, leukemia etc.；Radix Bupleuri feeble QI is fragrant, mildly bitter flavor, can antipyretic, antiinflammatory, promotion immunity
Function, anti-liver injury, Antiradiation injury etc.；The Radix Astragali has functions that invigorating QI to consolidate the body surface resistance, diuretic and maintain drug, evacuation of pus, expelling pus and promoting granulation, is used for
Treatment deficiency of vital energy weak, anorexia and loose stool, sinking of QI of middle-JIAO, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, blood deficiency and yellow complexion, Heat Diabetes；Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae)
Really cold in nature, bitter in the mouth, puckery, cure mainly anticancer, eliminating stagnation, removing blood stasis, for kinds of tumors, such as gastric cancer, intestinal cancer, chorionic epithelioma,
Lymphosarcoma etc., with stronger active anticancer；Herb Gynostemmae Pentaphylli sweet in the mouth, hardship, cold nature, return lung warp, spleen channel, kidney channel, energy QI invigorating, peace
God, blood pressure lowering, heat-clearing and toxic substances removing, eliminating phlegm and stopping cough；Radix glycyrrhizae taste sweet, mild-natured and, enter the heart, spleen, lung, stomach four are passed through, raw with cooler, can be rushed down
Fire removing toxic substances, relieving spasm to stop pain, dissipate exterior cold, invigorating the spleen and replenishing QI；Rhizoma Curcumae acrid in the mouth, hardship, return liver warp, spleen channel have blood-breaking pain relieving, circulation of qi promoting to disappear
Product analgesic efficacy, is suitable to drinking and eating irregularly, the disease of gastral cavity abdomen overflow pain；Lentinus Edodess are cold in nature, mildly bitter flavor, effect of favourable liver stomach reinforcing, promote
Enter human metabolism, improve organism adaptation power, can be used for dyspepsia, constipation, fat-reducing, with anti-virus ability.
Chinese medicine composition described in this has advantages below：
The Chinese medicine composition of the present invention, including Chinese fanpalm seed, Radix Bupleuri, the Radix Astragali, Fructus Camptothecae Acuminatae, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae, Rhizoma Curcumae, Lentinus Edodess,
In side, all medicine compatibilities play heat-clearing and toxic substances removing, removing blood stasis, spleen invigorating qi-regulating altogether, can be used for dyspepsia, constipation, promote human body new old generation
Thank, improve organism adaptation power, so as to suppressing or killing cancerous cell, with anti-virus ability.Above-mentioned formula not only the experiment proved that
There is to gastric cancer good therapeutic effect, prescription is simple, cheap, and fermentation technology can greatly improve herbal medicine efficacy and absorption
Effect, improve taste, the intestines and stomach coordinating, anticancer growth, enhance immunity, regulating intestinal canal colony balance improve the intestines and stomach work(
Waiting for energy is acted on.
Specific embodiment
With reference to specific embodiment, the present invention is expanded on further.
Embodiment 1
The first step, weighs Chinese fanpalm seed 5g, Radix Bupleuri 5g, Radix Astragali 6g, Fructus Camptothecae Acuminatae 8g, Herb Gynostemmae Pentaphylli 4g, Radix Glycyrrhizae 2g, Rhizoma Curcumae 3g, perfume (or spice)
Mushroom 1g, crushes, sieves, and mix homogeneously obtains fermentation raw material；Second step, lactic acid bacteria 3.4g is added in fermentation raw material, stirring
Load fermentation tank to be fermented after uniform；3rd step, at 33 DEG C, ferments 12 days, and extract at low temperature at 20 DEG C obtains fermentation and produces
Thing；4th step, tunning is dried, and adds dextrin, tabletting to make tablet.
Embodiment 2
The first step, weighs Chinese fanpalm seed 20g, Radix Bupleuri 15g, Radix Astragali 15g, Fructus Camptothecae Acuminatae 18g, Herb Gynostemmae Pentaphylli 12g, Radix Glycyrrhizae 10g, Rhizoma Curcumae
18g, Lentinus Edodess 12g, crush, sieve, and mix homogeneously obtains fermentation raw material；Bacillus bifiduss 6g is added to fermentation raw material by second step
In, load fermentation tank after stirring and fermented；3rd step, at 35 DEG C, ferments 11 days, and extract at low temperature at 25 DEG C is obtained
Tunning；4th step, tunning is dried, and is added starch, is made pill.
Embodiment 3
The first step, weighs Chinese fanpalm seed 12g, Radix Bupleuri 9g, Radix Astragali 10g, Fructus Camptothecae Acuminatae 15g, Herb Gynostemmae Pentaphylli 9g, Radix Glycyrrhizae 6g, Rhizoma Curcumae
12g, Lentinus Edodess 6g, crush, sieve, and mix homogeneously obtains fermentation raw material；Second step, yeast 5g is added in fermentation raw material,
Load fermentation tank to be fermented after stirring；3rd step, at 37 DEG C, ferments 10 days, and extract at low temperature at 45 DEG C is fermented
Product；4th step, adds dextrin in tunning, drying of pelletizing, and makes granule.
Embodiment 4
The first step, weighs Chinese fanpalm seed 8g, Radix Bupleuri 6g, Radix Astragali 8g, Fructus Camptothecae Acuminatae 12g, Herb Gynostemmae Pentaphylli 8g, Radix Glycyrrhizae 5g, Rhizoma Curcumae 8g, perfume (or spice)
Mushroom 3g, crushes, sieves, and mix homogeneously obtains fermentation raw material；Yeast 2g, lactic acid bacteria 1.5g are added to proferment by second step
In material, load fermentation tank after stirring and fermented；3rd step, at 38 DEG C, ferments 9 days, and extract at low temperature at 50 DEG C is obtained
Tunning；4th step, tunning is dried, and is added starch, is made powder.
Embodiment 5
The first step, weighs Chinese fanpalm seed 15g, Radix Bupleuri 12g, Radix Astragali 12g, Fructus Camptothecae Acuminatae 16g, Herb Gynostemmae Pentaphylli 10g, Radix Glycyrrhizae 8g, Rhizoma Curcumae
16g, Lentinus Edodess 8g, crush, sieve, and mix homogeneously obtains fermentation raw material；Second step, yeast 3g, bacillus bifiduss 5g are added to
In fermentation raw material, load fermentation tank after stirring and fermented；3rd step, at 40 DEG C, ferments 8 days, and at 55 DEG C, low temperature is carried
Take, obtain tunning；4th step, tunning is dried, and is added starch, is made powder.
Embodiment 6
The first step, weighs Chinese fanpalm seed 12g, Radix Bupleuri 8g, Radix Astragali 10g, Fructus Camptothecae Acuminatae 15g, Herb Gynostemmae Pentaphylli 8g, Radix Glycyrrhizae 6g, Rhizoma Curcumae
10g, Lentinus Edodess 5g, crush, sieve, and mix homogeneously obtains fermentation raw material；Second step, lactic acid bacteria 6g is added in fermentation raw material,
Load fermentation tank to be fermented after stirring；3rd step, at 40 DEG C, ferments 8 days, and extract at low temperature at 45 DEG C is fermented
Product；4th step, tunning is dried, and adds dextrin, filling dress capsule to make capsule.
Embodiment 7
The first step, weighs Chinese fanpalm seed 15g, Radix Bupleuri 12g, Radix Astragali 12g, Fructus Camptothecae Acuminatae 16g, Herb Gynostemmae Pentaphylli 10g, Radix Glycyrrhizae 8g, Rhizoma Curcumae
16g, Lentinus Edodess 8g, crush, sieve, and mix homogeneously obtains fermentation raw material；Second step, Mel 97g is inoculated in fermentation raw material, is stirred
Mix the uniform rear fermentation tank that loads to be fermented；3rd step, at 40 DEG C, ferments 8 days, and extract at low temperature at 55 DEG C obtains fermentation and produces
Thing；4th step, tunning is dried, and is added starch, is made powder.
Embodiment 8
The first step, weighs Chinese fanpalm seed 8g, Radix Bupleuri 6g, Radix Astragali 8g, Fructus Camptothecae Acuminatae 12g, Herb Gynostemmae Pentaphylli 8g, Radix Glycyrrhizae 5g, Rhizoma Curcumae 8g, perfume (or spice)
Mushroom 3g, crushes, sieves, and mix homogeneously obtains fermentation raw material；Second step, Mel 87g is inoculated in fermentation raw material, is stirred
Load fermentation tank afterwards to be fermented；3rd step, at 38 DEG C, ferments 9 days, and extract at low temperature at 50 DEG C obtains tunning；4th
Step, tunning is dried, and is added starch, is made powder.
Embodiment 9
The first step, weighs Chinese fanpalm seed 12g, Radix Bupleuri 9g, Radix Astragali 10g, Fructus Camptothecae Acuminatae 15g, Herb Gynostemmae Pentaphylli 9g, Radix Glycyrrhizae 6g, Rhizoma Curcumae
12g, Lentinus Edodess 6g, crush, sieve, and mix homogeneously obtains fermentation raw material；Second step, Mel 158g is inoculated in fermentation raw material,
Load fermentation tank to be fermented after stirring；3rd step, at 37 DEG C, ferments 10 days, and extract at low temperature at 45 DEG C is fermented
Product；4th step, adds dextrin in tunning, drying of pelletizing, and makes granule.
In embodiment 7-9, using Mel as strain raw material, the addition of Mel can improve Chinese medicine taste.
Experimental example：
In order to show that clinical therapeutic efficacy of the Chinese medicine composition of the present invention to gastric cancer, the following research approach of present invention design enter
Row efficacy is tested.
1st, clinical data
200 patients for being diagnosed as gastric cancer are carried out with clinical observation treatment, wherein matched group 100, treatment group 100.
2nd, Therapeutic Method
Matched group gives the medicine prepared by 1 method of Chinese patent literature CN105395697A embodiment according to daily two
Secondary, one after each meal serve on one month；Treatment group gives the granule of the preparation of the embodiment of the present invention 3, every time oral 6g, and daily two
Secondary, it serve on one month.
3rd, curative effect determinate standard
Basic healing：Clinical symptom disappearance after treatment, image and gastroscopy cancerous cell disappear, Continuous Observation 2 years with
On, without recurrence, can orthobiosiss, work.
Effective：After treatment, clinical symptoms partly or entirely disappear, and image and gastroscopy cancerous cell reduce more than half, and
More than 1 year person is maintained, patient can people's live and work as usual.
Effectively：Clinical symptom remission or mitigation after treatment, image and gastroscopy cancerous cell reduce or are controlled and tieed up
Hold more than 1 year person.
Invalid：Symptom as treat before or increase.
4th, clinical effectiveness
Matched group cures 45 substantially, effective 23, effective 19, and invalid 13, total effective rate is 87%；Treatment group's base
This healing 54, effective 28, effective 14, invalid 4, total effective rate is 96%, and toxic and side effects do not occur during treatment.
According to clinical verification, the medicine that prepared by other embodiments of the invention also has the effect of embodiment 3.
Prove that by above-mentioned experiment the Chinese medicine composition of the present invention has good effect to gastric cancer, with control drug phase
Than the prescription of the present composition is simple, cheap, can be widely used in the treatment of gastric cancer.
Obviously, above-described embodiment is only intended to clearly illustrate example, and the not restriction to embodiment.Right
For those of ordinary skill in the art, can also make on the basis of the above description other multi-forms change or
Change, and thus extended obvious change or change still in protection scope of the present invention within.
Claims (10)
1. a kind of Chinese medicine composition, it is characterised in that including the raw material of following weight portion：5～20 parts of Chinese fanpalm seed, Radix Bupleuri 5～15
Part, 6～15 parts of the Radix Astragali, 8～18 parts of Fructus Camptothecae Acuminatae, 4～12 parts of Herb Gynostemmae Pentaphylli, 2～10 parts of Radix Glycyrrhizae, 3～18 parts of Rhizoma Curcumae, Lentinus Edodess 1～12
Part.
2. Chinese medicine composition according to claim 1, it is characterised in that including the raw material of following weight portion：Chinese fanpalm seed 8～
15 parts, 6～12 parts of Radix Bupleuri, 8～12 parts of the Radix Astragali, 12～16 parts of Fructus Camptothecae Acuminatae, 8～10 parts of Herb Gynostemmae Pentaphylli, 5～8 parts of Radix Glycyrrhizae, Rhizoma Curcumae 8～
16 parts, 3～8 parts of Lentinus Edodess.
3. Chinese medicine composition according to claim 2, it is characterised in that including the raw material of following weight portion：Chinese fanpalm seed 12
Part, 9 parts of Radix Bupleuri, 10 parts of the Radix Astragali, 15 parts of Fructus Camptothecae Acuminatae, 9 parts of Herb Gynostemmae Pentaphylli, 6 parts of Radix Glycyrrhizae, 12 parts of Rhizoma Curcumae, 6 parts of Lentinus Edodess.
4. the Chinese medicine composition according to claims 1 to 3 any one, it is characterised in that the Chinese medicine composition is made
Pharmaceutically acceptable preparation.
5. Chinese medicine composition according to claim 4, it is characterised in that the preparation is pill, tablet, granule, glue
Any one in wafer, powder.
6. the preparation method of the Chinese medicine composition described in a kind of claim 4, it is characterised in that comprise the following steps：The first step,
Weigh Chinese fanpalm seed, Radix Bupleuri, the Radix Astragali, Fructus Camptothecae Acuminatae, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae, Rhizoma Curcumae, Lentinus Edodess by weight, crush, sieve, mix homogeneously
Obtain fermentation raw material；Second step, strain is added in fermentation raw material, loads fermentation tank and fermented after stirring；3rd
Step, at 33～40 DEG C, ferments 8～12 days, and extract at low temperature at 20～60 DEG C obtains tunning；4th step, adds medicinal auxiliary
Material, makes pharmaceutically acceptable preparation.
7. the preparation method of Chinese medicine composition according to claim 6, it is characterised in that in second step, the strain is honeybee
Honey or probiotic bacteria.
8. the preparation method of Chinese medicine composition according to claim 7, it is characterised in that the Mel and fermentation raw material
Part by weight is 1～2：1, the probiotic bacteria is 0.05～0.1 with the part by weight of fermentation raw material:1.
9. the preparation method of Chinese medicine composition according to claim 6, it is characterised in that in the 3rd step, at 37 DEG C,
Fermentation 10 days, extract at low temperature at 45 DEG C obtains tunning.
10. application of the arbitrary Chinese medicine composition of claims 1 to 3 in treatment gastric cancer medicament is prepared.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610839148 | 2016-09-21 | ||
| CN2016108391483 | 2016-09-21 |
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| CN106492123A true CN106492123A (en) | 2017-03-15 |
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| CN201611120865.7A Pending CN106492123A (en) | 2016-09-21 | 2016-12-08 | A kind of Chinese medicine composition and preparation method thereof and the application for the treatment of gastric cancer |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111165730A (en) * | 2018-11-12 | 2020-05-19 | 王庆友 | Dietotherapy anticancer capsule with cancer cell killing effect |
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