CN1557380A - Anticancer oral administered Chinese medicinal preparation - Google Patents
Anticancer oral administered Chinese medicinal preparation Download PDFInfo
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- CN1557380A CN1557380A CNA2004100126932A CN200410012693A CN1557380A CN 1557380 A CN1557380 A CN 1557380A CN A2004100126932 A CNA2004100126932 A CN A2004100126932A CN 200410012693 A CN200410012693 A CN 200410012693A CN 1557380 A CN1557380 A CN 1557380A
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Abstract
The anticancer Chinese medicine orally taken preparation has the recipe comprising Chinese fanpalm seed 2-14 (in weight portions, the same below), common camptotheca seed 1-10, zedoary 2-6, bupleurum root 2-6, gynostemma pentaphylla 2-6, Xianggu mushroom 0-3, astragalus root 0-6 and licorice 0-1. The animal test and the clinical test show that the medicine can promote blood circulation to disperse blood clots, invigorate spleen and remove food stagnancy, has obvious auxiliary treating and synergistic effect on radiotherapy and chemotherapy, and can improve the clinical symptoms of liver cancer and stomach cancer.
Description
Technical field
The invention belongs to the particularly oral preparation of Chinese traditional medicinal of gastric cancer and hepatocarcinoma of treatment cancer
Background technology
Cancer is one of common disease of serious prestige association's people ' s health and life security, not only jeopardizes patient's life, and the mortality rate height, brings massive losses for family and society, is a current class disease that is difficult to treatment.Hepatocarcinoma particularly, the course of disease is shorter, development rapidly, symptom is rapid, when symptom appearred in the patient, great majority reached an advanced stage, and had lost the best opportunity of excision.Also lack other therapy measure at present, nature is shorter life cycle, is one of the most dangerous cancer.And gastric cancer also is modal cancer kind.Capture these cancers and become numerous scientific and technical personnel's striving direction.Whole world health organization is captured big problem to cancer as emphasis always, and treatment of cancer has also been obtained some experiences.Majority is to adopt Comprehensive Treatment now, but does not all also find ideal Therapeutic Method.
In disclosed technology, occurred using Chinese fanpalm seed, Fructus Camptothecae Acuminatae and other medical material to be used as medicine and prepared the report of cancer therapy drug.Facts have proved that these medicines truly have anticancer function.Their main attribute is expressed as follows:
1. Chinese fanpalm seed is the dry mature fruit of babassu Semen livistonae chinensis Livistona chinensis R.Br.Sweet, puckery, flat.Anticancer.
" southern vegetation shape " recorded and narrated: sweet, puckery, flat." south of the Five Ridges gather medicinal herbs record " recorded and narrated: fry perfume (or spice) and fry in shallow oil diseases caused by retention of fluid, can control traumatic hemorrhage." Yunnan Chinese herbal medicine " recorded and narrated: seed of Livistona chinensis R.Br. is anticancer." Luchuan book on Chinese herbal medicine " recorded and narrated: hemostasis, control traumatic hemorrhage." Chinese herbal medicine handbook commonly used is recorded and narrated: treat various cancers in Guangzhou army.
In clinical practice, " Chinese medicine voluminous dictionary " recorded and narrated: treat various cancers, and seed of Livistona chinensis R.Br., one or two, decocting was obeyed in one to two hour, or stewed clothes with Carnis Sus domestica." a collection of selected materials of the Guangxi Minority side of making " recorded and narrated: curing oncoma, seed are fried in shallow oil the water clothes or are stewed clothes with pig's feet.
2. Fructus Camptothecae Acuminatae is the dry mature fruit of Nyssaceae (Nyssaceae) plant camptotheca acuminata Camptotheca acuminata Decne.Bitter in the mouth, cold, anticancer, eliminating stagnation, removing blood stasis.Be used for various tumors, as gastric cancer, intestinal cancer, chronic granulocyte, leukemia, chorionic epithelioma, malignant mole, lymphosarcoma, the hepatosplenomegaly that schistosomicide causes.
The alcohol extract of [pharmacology] Fructus Camptothecae Acuminatae and root can make total white blood cells descend in to white mice leukemia L-615, ascitic type reticulosarcoma (ARS) and the test of viral leukemia, and spleen heavily alleviates, and ascites reduces, and the oncocyte number of living in the ascites reduces.Fructus Camptothecae Acuminatae steeping in wine cream injection prolongs 40.9% to L-615 leukemia survival time of animals; To the yoshida sarcoma suppression ratio 60% of subcutaneous vaccination, and significantly suppress ascites and the tumor cell growth of ehrlich carcinoma mice.Anticancer main component is a α hydroxy-lactone ring in the camptothecine, and hydroxy camptothecin all has the effect similar to camptothecine with methoxycamptothecine to leukemia L-1210.Heavy dose of camptothecine can reduce the phosphorus content of ribonucleic acid in the liver, thereby suppresses nucleic acid metabolism.Camptothecine has certain toxic reaction, mainly shows the inhibition to digestive system, urinary system and hemopoietic function.
During tumor, appetite enhancement, weight increase, lump are dwindled the treatment human primary gastrointestinal cancers or focus diminishes, and hepatocarcinoma is had certain effect in treatment in clinical practice, treatment schistosomicide hepatosplenomegaly except that indivedual liver splenomegaly do not get better change, most subjective symptomss disappear.
3. Rhizoma Curcumae is the dry rhizome of zingiberaceous plant Rhizoma Curcumae (Curcuma phaeocaulis valeton.) Guangxi zedoary Curcumakuangsiensis S.G.Lee et C.F.Liang or RADIX CURCUMAE Curcuma wenyujin Y.H.Chen et C.king.Hot, bitter, warm, return liver, spleen channel.The circulation of qi promoting removing blood stasis, the removing food stagnancy pain relieving is used for the abdominal mass mass in the abdomen, blood stasis warp, food stagnation distending pain, early cervical carcinoma (one one of Chinese Pharmacopoeia nineteen ninety-five version).
" Thunder God big gun moxibustion opinion " recorded and narrated: " going into liver, spleen two warps "." product converge with essence will " be recorded and narrated: " removing mass is poly-." " the wood grass is logical profound " record: " specially walk liver man, removing mass gathers stagnant blood, dredges the expectorant food and has a pain ".
Curcumenol in the aromatic turmeric oil preparation and curcumadiol have obvious inhibition and destruction to the growth of multiple tumor strains such as the L615 leukemia of mice ehrlich ascites cell, 615 mouse inbred liness and ascites hepatoma cells; clinical prompting Rhizoma Curcumae has the effect of directly killing oncocyte; can also strengthen the oncocyte immunogenicity; thereby bring out or promote the immunological rejection of body, make animal obtain the significant protection effect tumor.
Clinical treatment cervicitis 165 examples, after one month, the curative effect statistics is for curing 31.5%, produce effects 15.2%, effective 24.9%, invalid 28.4%.Treatment coronary heart disease 50 examples, treated altogether 24 days two courses of treatment, and general symptoms such as the result is uncomfortable in chest, breathe hard, cardiopalmus, numb limbs and tense tendons improve after first course of treatment mostly; Angina pectoris 33 examples produce effects 69.7% after two courses of treatment improves 21.2%, invalid 9.1%; Electrocardiographic abnormality person 43 examples before the treatment are checked after treat two courses of treatment, produce effects 25.6%, improvement 39.5% is surplus invalid.
4. the dry root of Radix Bupleuri umbelliferae bupleurum (Bupleurum chinense DC or Radix Bupeuri Scorzonerfolii. Bupleurumscorzonerifolium willd).Hardship is slightly cold, and returns liver, gallbladder meridian.Evacuation is brought down a fever, soothing liver-QI, yang invigorating.Be used for cold, fever, alternate attack of chill and fever, malaria, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.(one one of Chinese Pharmacopoeia nineteen ninety-five version.)
Pharmacological research:
(1) calmness and anticonvulsant action mice climb experiment and rat conditioned avoidance response, have proved that Radix Bupleuri general glycoside and ruscogenin A have tangible motion to suppress and stable effect.
(2) analgesic activity confirms that with the experiment of electric shock Mus tail method saikoside can make the threshold of pain obviously increase.Someone thinks that saikoside also can bring into play analgesic activity by loose smooth muscle tone.
(3) the effect Radix Bupleuri to liver has the significantly anti-secretory action of damaging and promoting gallbladder antiperspirant to the hepatic injury due to Typhoid Vaccine, ethanol, carbon tetrachloride, the D-galactosamine etc.Saikoside can suppress the experimental hepatic injury due to D-galactosamine, carbon tetrachloride and α-naphthalene sulfocyanic ester.
(4) the antitumor action Saikosaponin d is to mice transplanted sarcoma S
180, P
388Reach ehrlich ascites cell and all be the obvious suppression effect, and can prolong the life of animal.
(5) to Immune Effects Radix Bupleuri polysaccharide significantly increase the spleen coefficient, peritoneal macrophage is engulfed percent and phagocytic index and influenza virus serum NAT.Can improve mice body fluid and cellular immune function.
Clinical practice treatment viral hepatitis, the effective percentage acute case is 98.4%, chronic case is 100%; Treatment herpes simplex virus keratitis 21 examples, 18 examples obtain promising result.Treatment erythema multiforme 13 examples were successively all cured in 10 days.
5. Herb Gynostemmae Pentaphylli is the dry herb of cucurbitaceous plant Herb Gynostemmae Pentaphylli [Gynostemma pentaphyllum (Thunb.) Makino].Hardship, little sweet, cold.Heat-clearing and toxic substances removing, eliminating phlegm and stopping cough, supplementing QI and nourishing YIN, slow down aging.It is vexed to be used for the chest and diaphragm painful abdominal mass, stagnation of phlegm blood stasis, shortness of breath and palpitation, dizziness and headache, forgetful tinnitus, unconsciously sweat and tire, hyperlipidemia, Simple Obesity, old cough.(Guangxi Chinese crude drug standard 1990 editions)
Pharmacological research:
(1) press down function of tumor: gypenoside has the inhibition effect to multiple cancer, to the normal cell free of toxic effects.Herb Gynostemmae Pentaphylli can prevent the normal cell cancerization, and the ability of impelling cell performance oneself to cure, and guiding cancerization cellular-restoring is normal.
(2) immunoregulation effect: the decline that gypenoside can make that mouse immune organ spleen is heavy, anti-SRBC hemolysin level and active E-Flos Rosae Rugosae formation rate are higher than median, be lower than the rising of median, show dual regulation.
(3) hepatoprotective effect: Herb Gynostemmae Pentaphylli has the lipid peroxidation that suppresses impaired hepatic tissue to the carbon tetrachloride hepatic injury rat, and GPT is descended
Clinical practice treatment radiotherapy, chemotherapy cause leukopenia, test 31 examples, leukocyte increasing to 4 * 10
9The above average number of days of/L is 4.69 days.In China's successive dynasties book on Chinese herbal medicine, can not find the record of this plant medical value, but among the people commonly used with detoxifcation, eliminating phlegm and stopping cough, the treatment chronic tracheitis.Gypenoside is equipped with other medicines, also can be made into hair conditioner, deodorizer etc.
6. Lentinus Edodes is the dry sporophore of sidelong glance section plant Lentinus Edodes [Lentinusedodes (Berk.) sing].Sweet, flat, stomach reinforcing gas, the holder varioliform exanthema is controlled the wind removing blood stasis, and phlegm-eliminiating and qi-regulating is the vitamin compensation.Be used for mushroom poisoning, treating measles, hypertension, edema, headache, dizziness, the weak and avitaminosis of health.
(Guangxi Chinese crude drug standard 1990 editions)
" it is former that book on Chinese herbal medicine is asked " carries: the fragrant letter of name, " specially going into stomach "." daily book on Chinese herbal medicine " carries: " QI invigorating, not hungry, control the wind removing blood stasis." " book on Chinese herbal medicine meets the source " carry: " big stomach reinforcing gas ".
Pharmacological research:
Lentinan and Lc-11 are respectively 97.8% and 93.6% to mouse transplanting tumor S-180 suppression ratio.The Ks-2 that extracts in the mushroom mycelium culture can suppress the growth of mice or the various metastatic tumors of rat, and influenza virus A2 infecting mouse is had protective effect.
7. the Radix Astragali is the dry root of leguminous plant Radix Astragali Astragalu smembranaceus (Fisch) Bge.Var.mongholicus (Bge.) Hsiao or Radix Astragali Astragalus membranaceus (Fisch) Bge.Gan Wen.Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.It is weak to be used for the deficiency of vital energy, anorexia and loose stool, and sinking of QI of middle-JIAO, the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and burst for a long time and do not hold back, the blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst, chronic nephritis proteinuria, diabetes.(one one of Chinese Pharmacopoeia nineteen ninety-five version)
Radix Astragali original name Radix Astragali, the beginning is stated from " herbal classic "." herbal classic " carries: " main carbuncle, lose skin ulcer for a long time, evacuation of pus pain relieving, strong wind leprosy disease, five hemorrhoid, scrofula, tonify deficiency, children's's all kinds of diseases and ailments." " property of medicine opinion " carry: " and control carbuncle on the back, interior benefit, main dyspnea due to deficiency, renal failure, deafness is treated cold and heat.Give birth to west of Gansu Province person, following tonifying five ZANG-organs ".Essentials of Matea Medica carries: " hemopoietic, granulation promoting, evacuation of pus expelling the toxic substance from the body with tonic, carbuncle sore panacea.Varioliform exanthema does not rise, yang deficiency do not have hot person suitable it ".
Pharmacological research:
(1) the antitumaous effect astragalus polysaccharides is to easily being activated by IL-2 from cancer ascites medium-sized lymphocyte (CTL), CTL after the activation surrounds around the tumor cell, is the Flos Rosae Rugosae flowers, and vacuolar degeneration at first appears in the tumor cell that is held in endochylema, finally cause death, CTL propagation is also very fast.
(2) to immune influence
To non-specific immunity: the Radix Astragali can be prevented and treated the reduction of the platelet count and the bone marrow megakaryocyte number of caused by cyclophosphamide rat peripheral blood leucocyte, Reticulocyte.Mouse gavaging Radix Astragali decoct can significantly improve carbon and clean up index, and the spleen that injection Radix Astagali polysaccharide (APS) causes cyclophosphamide weighs and thymic weight alleviates the effect of having clear improvement, and the phagocytic rate of peritoneal macrophage and phagocytic index are obviously raise.
To humoral immune function: Radix Astagali promotes the effective ingredient of humoral immunization to contain polysaccharide, protein macromolecule, and the component that contain aminoacid, alkaloid, contains glycoside also has remarkable result.
Clinical practice treatment advanced schistosomiasis, all the case symptom is obviously improved, and enlargement under the liver sword sky, spleen enlargement have many soft contracting.
8. Radix Glycyrrhizae is the dry root and rhizome of glycyrrhizic legume Glycyrrhizauralensis Fisoh. Glycyrrhiza inflata Bat. Glycyrrhizaglabra L..Sweet, flat.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, tired happy weak, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, the swollen sore of pain, cushion toxicity.
" herbal classic " carries: " main vital organs of the human body cold and heat pathogen, hard muscles and bones, longue meat, times power, incised wound is swollen, detoxifcation." " not Lu " carry: " and warming the middle warmer and descending qi, stuffy sensation with restlessness is losed heart, and hinders dirty cough, the qualcomm meridian that quenches the thirst, sharp vim and vigour are separated hundred poison of drug "." solar corona " carries: " the peace soul is decided soul, mends the five kinds of over strain leather and hinders, and all are deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle is separated cold and hot.Be used as medicine and process usefulness ".
Pharmacological research:
(1) antitumor and antimutagenic effect Radix Glycyrrhizae are 60% to the Wister rat blocking-up rate that nitrosoguanidine brings out.Glycyrrhizic acid all has inhibitory action to rat ascites hepatocarcinoma, mice ehrlich carcinoma, yoshida sarcoma and polyoxy biphenyl induced mice hepatocarcinoma.Can strengthen the detoxification ability and the resistance of cell, and not have the serious side effects of anticarcinogen.
(2) Detoxication effective liquorice is a glycyrrhizin, to multiple drug intoxication, metabolite poisoning, bacteriotoxin poisoning, pesticide intoxication, and all certain detoxifying effect of alimentary toxicosis.
Though one or more the medicine that has adopted in the said medicine is arranged in disclosed cancer therapy drug technology, because the prescription difference of various medicines, the compatibility of medicine is also not necessarily very suitable, cause the curative effect of medicine and price that not little difference is arranged.The applicant tries hard to seek a kind of better efficacy, little, the cheap cancer therapy drug of side effect.
Summary of the invention
It is the cancer therapy drug of principal agent with Chinese fanpalm seed, Fructus Camptothecae Acuminatae etc. that the technical problem to be solved in the present invention provides a kind of.
The present invention solves the problems of the technologies described above with following technical scheme:
Prescription of the present invention is (weight portion):
Chinese fanpalm seed 2～14 Fructus Camptothecae Acuminatae 1～10 Rhizoma Curcumae 2～6 Radix Bupleuri 2～6 Herb Gynostemmae Pentaphylli 2～6
Lentinus Edodes 0～3 Radix Astragali 0～6 Radix Glycyrrhizae 0～1
Preparation technology:
Astragalus membranaceus powder is broken into fine powder; The Rhizoma Curcumae vapor distillation extracts volatile oil, and the water decoction of medicinal liquid after the distillation and Chinese fanpalm seed, Radix Bupleuri, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae merges, and after concentrating, adds ethanol and reaches more than 60% to containing the alcohol amount, and precipitation filters, and filtrate is concentrated into thick paste; Lentinus Edodes decocts with water, and filters, and filtrate is concentrated into thick paste, merges with above-mentioned thick paste, and Radix Astragali fine powder and adjuvant are added in the thick paste, is dried to dried cream; The Fructus Camptothecae Acuminatae coarse powder is with 60% above ethanol percolation, and the liquid of filtering is concentrated into thick paste, adds residue astragalus membranaceus powder and adjuvant, and mixing is dried to dried cream.Above-mentioned dried cream is merged, be ground into fine powder, volatile oil adsorbs with adjuvant, with above-mentioned fine powder mixing, makes granule, tablet, capsule.
When producing oral liquid, the Rhizoma Curcumae vapor distillation extracts volatile oil, and the decocting liquid merging of medicinal liquid after the distillation and Chinese fanpalm seed, Radix Bupleuri, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae after concentrating, adds ethanol and reaches more than 60% to containing the alcohol amount, precipitation, filtration, and filtrate is concentrated into regulation density; Lentinus Edodes decocts with water, and filters, and filtrate is concentrated into regulation density; The Fructus Camptothecae Acuminatae coarse powder behind the diacolation liquid recycling ethanol, is concentrated into regulation density with 60% above ethanol percolation; Merge above-mentioned medicinal liquid, filter.Volatile oil is dissolved in the medicinal liquid with cosolvent, and adds an amount of flavoring agent, antiseptic, transfers to ormal weight with distilled water, stirs evenly, and leaves standstill, filter, and embedding, sterilization promptly gets oral liquid.
It is as follows that product of the present invention is carried out animal test results:
1, anticancer test:
Can obviously suppress mouse entity hepatocarcinoma H
22And S
180Growth, can make H
22The life span of ascitic type mice prolongs;
2, to the effect of tumor-bearing mice immunologic function: treatment makes the carbon clearance speed K value of tumor-bearing mice apparently higher than matched group; In the test of delayed hypersensitive reaction, optical density value is apparently higher than matched group; Generation influence to hemolysin is not obvious.
3, to the not normal mice with spleen deficiency test of diet, obviously prolong swimming time.
4, to the mouse writhing reaction test, reduced the writhing response number of times that HAC causes, prompting has certain analgesic activity.
5, to the absorption test of rabbit ear ecchymoma speckle, prompting can promote the absorption of rabbit ear ecchymoma.
Human clinical trial's situation is as follows:
One, diagnostic criteria:
1. hepatocarcinoma:
Western medicine diagnose turns out to be primary hepatocarcinoma, and the extrahepatic tissue inspection is a hepatocarcinoma.Chinese medical discrimination is a Blood stasis, and the long-pending piece matter of pressing is hard down in right association, and distending pain or twinge are scurried and both sides of the chest, purplish tongue or ecchymosis is arranged, white and thin fur, stringy pulse or puckery.
2, gastric cancer:
Western medicine diagnose: big belly or pain, tenderness, carrying out property anemia, become thin or the change of ulcer symptom rule, inappetence, vomiting, hematemesis or have blood in stool, gastric juice, gastric acid reduce, the upper digestive tract radiography is not normal, tumor or large stretch of ulcer are seen in the inspection of gastric sight glass, gastric juice has the cancerous cell of coming off, all clear and definite gastric cancer pathological diagnosis of biopsy, specimen.
Chinese medical discrimination is a Blood stasis: gastral cavilty distension, enclosed mass firmly, bitterly, body of the tongue is greasy in vain or ecchymosis is arranged, white and thin fur, deep and hesitant pulse.
3, clinical stages:
Hepatocarcinoma:
The I phase: do not have clear and definite hepatocarcinoma symptom, sign, CT, B ultrasonic are found single tuberosity, and diameter is less than 5cm person.
The II phase: symptom is lighter, and ordinary circumstance is fair, does not have III phase evidence person above I phase standard.
The III phase: one of the outer transfer of obvious cachexia, jaundice, ascites or liver person is arranged.
Gastric cancer:
The I phase: though no lymphatic metastasis or tumor are invaded the flesh layer, extent of disease is no more than 1 subregion person.
The II phase: have the shallow type gastric cancer of table of first stop lymphatic metastasis and tumor to invade the flesh layer, extent of disease surpasses 1 subregion, the T that does not have or only have the shallow tissue lymph at contiguous position to carry down and move
3Tumor.
The III phase: have the shallow tissue lymph of remote part to carry down and move or near dark group lymphatic metastasis; Or the shallow tissue lymph that contiguous position is only arranged carries down and moves even do not have transfer, but the tumor size surpasses 1 subregion or involved surrounding tissue person.
The IV phase: no matter the tumor size, allly have by metastasis or hepatic portal, the coeliac artery, by the ventral aorta, arteria colica media is other or the lymphatic metastasis of mesentery root.
4, card labor Paderewski (Karnofsky) point system is adopted in scoring
Two, case is selected:
Include standard in: meet simultaneously that hepatocarcinoma or diagnosing gastric cancer standard, Chinese medical discrimination belong to Blood stasis, physical situation is marked more than 60 minutes.
Exclusion standard: the age is less than 18 years old or greater than 65 years old; Gestation or women breast-feeding their children; Allergic constitution or to this medicine allergy sufferers; Merge serious constitutional disease such as cardiovascular and cerebrovascular vessel, Liver and kidney, hemopoietic system; The psychotic; Not medication in accordance with regulations, can't judge the full person of curative effect or data.
Three, observational technique: adopt district's group at random, contrast, non-blind method observe.
1, grouping: observe 240 examples altogether, look into the random digit tabulation, by 1: 1 district's group random packet.
2, the consumption course of treatment and medication:
The treatment group: radiotherapy routinely, chemotherapy regimen treatment add uses medicine of the present invention, obeys 4, every day 3 times at every turn;
Matched group: radiotherapy routinely, chemotherapy regimen treatment;
The course of treatment: all around;
Viewing duration does not use other similar medicine.
Four, observation index:
1, safety observation:
General physical examination project; Blood, urine, just routine examination; The heart, liver, kidney function test.
2, health giving quality observation:
The variation of relevant clinical symptom; Liver function test and relevant zymetology, immunologic test; Necessary iconography or splanchnoscopy.
Five, efficacy assessment standard:
1, recent cancer curative effect determinate standard:
Alleviate fully-visible pathological changes complete obiteration.
Part alleviation-lump dwindles more than 50%
Stable-lump dwindles not as good as 50% or increases above 25%.
Progress-one or more pathological changes increase more than 25% or new pathological changes occurs.
2, the variation of health status is with all marking description variations before and after treatment of Karnofsky method.
3, clinical symptoms curative effect:
Keep the score by clinical symptoms weight standard.Symptom and sign is clearly better or disappears, sees that it is produce effects that the disease integration reduces more than 91%; The symptom Signs takes a turn for the better, sees that the disease integration reduces 61-90% for effective, and it is invalid not reaching above standard.
Six, statistical procedures result: ranked data Ridit analytic process, enumeration data X
2Method of inspection; Measurement data t method of inspection.
The result:
Experimenter's 240 examples are hepatocarcinoma, patients with gastric cancer, wherein hepatocarcinoma, patients with gastric cancer each half, treatment group in each sick kind, matched group each half.
Two groups of sexes, age, sick plant distribution, the course of disease, clinical stagess relatively, state of an illness difference there are no significant meaning before the treatment.Compare treatment back cancer curative effect in the recent period, to gastric cancer (not accepting the chemotherapy person after not containing operation) significance.Before and after iconography or the treatment of splanchnoscopy tumor area, relatively, gastric cancer (not accepting the chemotherapy person after not containing operation) patient there is the obvious suppression potentiation.Lab testing is the result show: body fluid and cellular immune function to patients with gastric cancer have certain help.The Karnofsky appraisal result shows: improving patient on quality of life, more obvious to gastric cancer.
After treatment the clinical symptoms curative effect relatively in, the prompting medicine can improve the clinical symptoms of hepatocarcinoma, gastric cancer, improves limbs asthenia symptom.
The symptom that all has no adverse reaction after two groups of medications, safe and reliable.
In clinical use, this medicine can strengthen the curative effect of radiotherapy, chemotherapy to gastric cancer, hepatocarcinoma, and can the enhancing human body immunity function, improves clinical symptoms.
Through animal experiment and clinical trial, prove product blood circulation promoting and blood stasis dispelling of the present invention, spleen invigorating removing food stagnancy, curing gastric cancer group short term effect total effective rate is 83.3%, hepatocarcinoma 51.7%.Conventional radiotheraphy, chemotherapy regimen treatment gastric cancer there are obviously auxiliary, potentiation, can improve the clinical symptoms of gastric cancer, hepatocarcinoma.
The specific embodiment
Prescription of the present invention is (weight portion):
Chinese fanpalm seed 2～14 Fructus Camptothecae Acuminatae 1～10 Rhizoma Curcumae 2～6 Radix Bupleuri 2～6 Herb Gynostemmae Pentaphylli 2～6
Lentinus Edodes 0～3 Radix Astragali 0～6 Radix Glycyrrhizae 0～1
Its preparation technology is:
Astragalus membranaceus powder is broken into fine powder; The Rhizoma Curcumae vapor distillation extracts volatile oil, and the water decoction of medicinal liquid after the distillation and Chinese fanpalm seed, Radix Bupleuri, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae merges, and after concentrating, adds ethanol and reaches more than 60% to containing the alcohol amount, and precipitation filters, and filtrate is concentrated into thick paste; Lentinus Edodes decocts with water, and filters, and filtrate is concentrated into thick paste, merges with above-mentioned thick paste, and Radix Astragali fine powder and adjuvant are added in the thick paste, is dried to dried cream; The Fructus Camptothecae Acuminatae coarse powder is with 60% above ethanol percolation, and the liquid of filtering is concentrated into thick paste, adds residue astragalus membranaceus powder and adjuvant, and mixing is dried to dried cream.Above-mentioned dried cream is merged, be ground into fine powder, volatile oil adsorbs with adjuvant, with above-mentioned fine powder mixing, makes granule, tablet, capsule.
When producing oral liquid, the Rhizoma Curcumae vapor distillation extracts volatile oil, and the decocting liquid merging of medicinal liquid after the distillation and Chinese fanpalm seed, Radix Bupleuri, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae after concentrating, adds ethanol and reaches more than 60% to containing the alcohol amount, precipitation, filtration, and filtrate is concentrated into regulation density; Lentinus Edodes decocts with water, and filters, and filtrate is concentrated into regulation density; The Fructus Camptothecae Acuminatae coarse powder behind the diacolation liquid recycling ethanol, is concentrated into regulation density with 60% above ethanol percolation; Merge above-mentioned medicinal liquid, filter.Volatile oil is dissolved in the medicinal liquid with cosolvent, and adds an amount of flavoring agent, antiseptic, transfers to ormal weight with distilled water, stirs evenly, and leaves standstill, filter, and embedding, sterilization promptly gets oral liquid.
Embodiment 1:
1, prescription: Chinese fanpalm seed 480g Fructus Camptothecae Acuminatae 120g Herb Gynostemmae Pentaphylli 120g Rhizoma Curcumae 120g
Radix Bupleuri 120g Lentinus Edodes 60g Radix Astragali 120g Radix Glycyrrhizae 60g
2, preparation technology: astragalus membranaceus powder is broken into fine powder, and the Rhizoma Curcumae vapor distillation extracts volatile oil, the aqueous solution after the distillation, and device is collected in addition; Chinese fanpalm seed, Radix Bupleuri, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae decoct with water secondary, each 2 hours, collecting decoction filters, and the aqueous solution after filtrate and the Rhizoma Curcumae distillation merges, being concentrated into relative density is the clear paste of 1.04～1.05 (80 ℃), add ethanol and reach 60%, stir evenly, leave standstill to containing the alcohol amount, filter, filtrate is concentrated into the thick paste that relative density is 1.38～1.41 (80 ℃); Lentinus Edodes decocts with water three times, and each one hour, filter, merging filtrate, being concentrated into relative density is the thick paste of 1.38～1.41 (80 ℃), merges with above-mentioned thick paste, adds astragalus membranaceus powder and the adjuvant calcium hydrogen phosphate is an amount of, mixing is dried to dried cream; Fructus Camptothecae Acuminatae is ground into coarse powder, makes solvent with 60% ethanol, soak 24 hours after, percolation, the liquid of filtering are concentrated into the thick paste that relative density is 1.38～1.41 (80 ℃), add residue astragalus membranaceus powder and an amount of calcium hydrogen phosphate, mixing is dried to dried cream in 50～60 ℃, merges above-mentioned dried cream, be ground into fine powder, Rhizoma Curcumae volatile oil adds an amount of mixing of calcium hydrogen phosphate, with above-mentioned fine powder mixing, adds calcium hydrogen phosphate to 380g again, mixing incapsulates and makes 1000.
Embodiment 2:
1, prescription: Chinese fanpalm seed 350g Fructus Camptothecae Acuminatae 250g Herb Gynostemmae Pentaphylli 150g Rhizoma Curcumae 150g
Radix Bupleuri 150g Lentinus Edodes 50g Radix Astragali 150g Radix Glycyrrhizae 25g
2, preparation technology: astragalus membranaceus powder is broken into fine powder, and the Rhizoma Curcumae vapor distillation extracts volatile oil, the aqueous solution after the distillation, and device is collected in addition; Chinese fanpalm seed, Radix Bupleuri, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae decoct with water secondary, each 2 hours, collecting decoction filters, and the aqueous solution after filtrate and the Rhizoma Curcumae distillation merges, being concentrated into relative density is the clear paste of 1.04～1.05 (80 ℃), add ethanol and reach 70%, stir evenly, leave standstill to containing the alcohol amount, filter, merging filtrate is concentrated into the thick paste that relative density is 1.38～1.41 (80 ℃); Lentinus Edodes decocts with water three times, and each 1 hour, filter, merging filtrate, being concentrated into relative density is the thick paste of 1.38～1.41 (80 ℃), merges with above-mentioned thick paste, adds astragalus membranaceus powder and starch is an amount of, mixing is dried to dried cream; Fructus Camptothecae Acuminatae is ground into coarse powder, makes solvent with 70%7 alcohol, soak 24 hours after, percolation, the liquid of filtering is concentrated into the thick paste that relative density is 1.38～1.41 (80 ℃), adds residue astragalus membranaceus powder and appropriate amount of starch, and mixing is dried to dried cream in 50～60 ℃, merge above-mentioned dried cream, be ground into fine powder, granulate drying.Volatile oil adds an amount of mixing of starch, and with above-mentioned granule mixing, tabletting, coating is made 1000.
Embodiment 3:
1, prescription: Chinese fanpalm seed 375g Fructus Camptothecae Acuminatae 275g Herb Gynostemmae Pentaphylli 175g
Rhizoma Curcumae 175g Radix Bupleuri 175g Lentinus Edodes 50g Radix Astragali 75g
2, preparation technology: astragalus membranaceus powder is broken into fine powder, and the Rhizoma Curcumae vapor distillation extracts volatile oil, the aqueous solution after the distillation, and device is collected in addition; Chinese fanpalm seed, Radix Bupleuri, Herb Gynostemmae Pentaphylli decoct with water secondary, each 2 hours, collecting decoction filters, and the aqueous solution after filtrate and the Rhizoma Curcumae distillation merges, being concentrated into relative density is the clear paste of 1.04～1.05 (80 ℃), add ethanol and reach 65%, stir evenly, leave standstill to containing the alcohol amount, filter, filtrate is concentrated into the thick paste that relative density is 1.38～1.41 (80 ℃).Lentinus Edodes decocts with water three times, and each 1 hour, filter, merging filtrate is concentrated into the thick paste that relative density is 1.38～1.41 (80 ℃), merges with above-mentioned thick paste, adds astragalus membranaceus powder and calcium hydrogen phosphate is an amount of, and mixing is dried to dried cream; Fructus Camptothecae Acuminatae is ground into coarse powder, makes solvent with 80% ethanol, soak 24 hours after, percolation, the liquid of filtering are concentrated into the thick paste that relative density is 1.38～1.41 (80 ℃), and it is an amount of to add residue astragalus membranaceus powder and calcium hydrogen phosphate, mixing is dried to dried cream in 50～60 ℃, merges above-mentioned dried cream, be ground into fine powder, volatile oil adds an amount of mixing of calcium hydrogen phosphate, with above-mentioned fine powder mixing, adds calcium hydrogen phosphate to 380g, mixing incapsulates and makes 1000.
Embodiment 4:
1, prescription: Chinese fanpalm seed 500g Fructus Camptothecae Acuminatae 375g
Rhizoma Curcumae 250g Radix Bupleuri 250g Herb Gynostemmae Pentaphylli 250g
2, preparation technology: the Rhizoma Curcumae vapor distillation, extract volatile oil, the aqueous solution after the distillation, device is collected in addition; Chinese fanpalm seed, Radix Bupleuri, Herb Gynostemmae Pentaphylli decoct with water secondary, each 2 hours, collecting decoction filters, and the aqueous solution after filtrate and the Rhizoma Curcumae distillation merges, being concentrated into relative density is the clear paste of 1.04～1.05 (80 ℃), add ethanol and reach 63%, stir evenly, leave standstill to containing the alcohol amount, filter, merging filtrate is concentrated into the thick paste that relative density is 1.38～1.41 (80 ℃); Fructus Camptothecae Acuminatae is ground into coarse powder, makes solvent with 60% ethanol, soak 24 hours after, percolation, the liquid of filtering are concentrated into the thick paste that relative density is 1.38～1.41 (80 ℃), merge with above-mentioned thick paste, add appropriate amount of starch, mixing is granulated drying.Volatile oil adds the appropriate amount of starch mixing, and with above-mentioned granule mixing, tabletting, coating is made 1000.
Embodiment 5
1 prescription: Chinese fanpalm seed 400g Fructus Camptothecae Acuminatae 350g
Rhizoma Curcumae 200g Radix Bupleuri 200g Herb Gynostemmae Pentaphylli 200g
2, preparation technology:
The above five tastes, the Rhizoma Curcumae vapor distillation extracts volatile oil, distilled water solution, device is collected in addition, Chinese fanpalm seed, Radix Bupleuri, Herb Gynostemmae Pentaphylli, decoct with water secondary, each 2 hours, collecting decoction, filter, filtrate and Rhizoma Curcumae distillation back filter liquor merge, and being concentrated into relative density is the clear paste of 1.05～1.1 (80 ℃), add ethanol to containing alcohol amount 63%, stir evenly, airtight, leave standstill, filter; Fructus Camptothecae Acuminatae is ground into coarse powder, makes solvent with 60% ethanol, soak 24 hours after, percolation, the liquid of filtering are concentrated into the clear paste that relative density is 1.08～1.1 (80 ℃), merge with above-mentioned filtrate, reclaim ethanol to there not being the alcohol flavor, add volatile oil tween hydrotropy, again with sucrose 80 grams, benzoic acid 0.5 gram is adjusted total amount to 1000 milliliter with distilled water, stirs evenly, leave standstill, filter, embedding, sterilization promptly gets oral liquid.
Claims (3)
1, a kind of Chinese medicine medicine for preventing oral formulations is characterized in that:
Prescription is (weight portion):
Chinese fanpalm seed 2～14 Fructus Camptothecae Acuminatae 1～10 Rhizoma Curcumae 2～6 Radix Bupleuri 2～6 Herb Gynostemmae Pentaphylli 2～6
Lentinus Edodes 0～3 Radix Astragali 0～6 Radix Glycyrrhizae 0～1
2, a kind of preparation technology of Chinese medicine medicine for preventing solid orally ingestible, it is characterized in that: astragalus membranaceus powder is broken into fine powder; The Rhizoma Curcumae vapor distillation extracts volatile oil, and the water decoction of medicinal liquid after the distillation and Chinese fanpalm seed, Radix Bupleuri, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae merges, and after concentrating, adds ethanol and reaches more than 60% to containing the alcohol amount, and precipitation filters, and filtrate is concentrated into thick paste; Lentinus Edodes decocts with water, and filters, and filtrate is concentrated into thick paste, merges with above-mentioned thick paste, and Radix Astragali fine powder and adjuvant are added in the thick paste, is dried to dried cream; The Fructus Camptothecae Acuminatae coarse powder is with 60% above ethanol percolation, and the liquid of filtering is concentrated into thick paste, adds residue astragalus membranaceus powder and adjuvant, and mixing is dried to dried cream.Above-mentioned dried cream is merged, be ground into fine powder, volatile oil adsorbs with adjuvant, with above-mentioned fine powder mixing, makes granule, tablet, capsule.
3, a kind of preparation technology of Chinese medicine medicine for preventing liquid oral medicine, it is characterized in that: the Rhizoma Curcumae vapor distillation, extract volatile oil, the decocting liquid of medicinal liquid after the distillation and Chinese fanpalm seed, Radix Bupleuri, Herb Gynostemmae Pentaphylli, Radix Glycyrrhizae merges, after concentrating, add ethanol and reach more than 60% to containing the alcohol amount, precipitation, filtration, filtrate is concentrated into regulation density; Lentinus Edodes decocts with water, and filters, and filtrate is concentrated into regulation density; The Fructus Camptothecae Acuminatae coarse powder behind the diacolation liquid recycling ethanol, is concentrated into regulation density with 60% above ethanol percolation; Merge above-mentioned medicinal liquid, filter.Volatile oil is dissolved in the medicinal liquid with cosolvent, and adds an amount of flavoring agent, antiseptic, transfers to ormal weight with distilled water, stirs evenly, and leaves standstill, filter, and embedding, sterilization promptly gets oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100126932A CN1557380A (en) | 2004-01-18 | 2004-01-18 | Anticancer oral administered Chinese medicinal preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100126932A CN1557380A (en) | 2004-01-18 | 2004-01-18 | Anticancer oral administered Chinese medicinal preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1557380A true CN1557380A (en) | 2004-12-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2004100126932A Pending CN1557380A (en) | 2004-01-18 | 2004-01-18 | Anticancer oral administered Chinese medicinal preparation |
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| Country | Link |
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| CN (1) | CN1557380A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106492123A (en) * | 2016-09-21 | 2017-03-15 | 深圳市得道中医馆管理有限责任公司 | A kind of Chinese medicine composition and preparation method thereof and the application for the treatment of gastric cancer |
| WO2017155834A1 (en) | 2016-03-08 | 2017-09-14 | Cheng Lab & Company, Llc | Herbal formulation to raise the human body's ph level from one that is acidic to one that is more alkaline |
-
2004
- 2004-01-18 CN CNA2004100126932A patent/CN1557380A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017155834A1 (en) | 2016-03-08 | 2017-09-14 | Cheng Lab & Company, Llc | Herbal formulation to raise the human body's ph level from one that is acidic to one that is more alkaline |
| EP3426043A4 (en) * | 2016-03-08 | 2019-10-23 | Cheng Lab&Company, LLC | Herbal formulation to raise the human body's ph level from one that is acidic to one that is more alkaline |
| CN106492123A (en) * | 2016-09-21 | 2017-03-15 | 深圳市得道中医馆管理有限责任公司 | A kind of Chinese medicine composition and preparation method thereof and the application for the treatment of gastric cancer |
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