CN1250275C - Traditional Chinese medicine for treating cancer and preparation method thereof - Google Patents

Traditional Chinese medicine for treating cancer and preparation method thereof Download PDF

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CN1250275C
CN1250275C CN 02131252 CN02131252A CN1250275C CN 1250275 C CN1250275 C CN 1250275C CN 02131252 CN02131252 CN 02131252 CN 02131252 A CN02131252 A CN 02131252A CN 1250275 C CN1250275 C CN 1250275C
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于天德
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Wantong Pharmaceutical Co., Ltd., Guangxi
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于天德
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Abstract

The present invention relates to a Chinese medicine preparation for treating malignant tumors and a preparation method thereof. The Chinese medicine preparation comprises raw material as follows: oldenlandia, glabrous sarcandra herb, barbed skullcap herb, corydalis tuber, common prism tuber, zedoary, danshen root, ginseng, astragalus root, ganoderma, spatholobus stem, rehmannia root, wolfberry fruit, dandelion, vietnamese sophora root, flavescent sophora root and liquorice. The preparation method comprises the steps of raw material preparation, preparation of the Chinese medicine preparation, finished product processing, packaging and inspection. Clinic results of the Chinese medicine preparation for treating cancer indicate that the Chinese medicine preparation has good therapeutic effect on various tumors; when patients take the medicines, tumor bodies of the patients are obviously decreased after a plurality of days; the Chinese medicine preparation has persistent pain-alleviating effect on late cancer pain. Besides, the patients suffering from various kinds of cancer have no adverse or toxic and side effect, and the Chinese medicine preparation can achieve the effects of relieving symptoms and extending service life to all the patients suffering from the cancer.

Description

A kind of Chinese medicine preparation for the treatment of malignant tumor and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, particularly treat Chinese medicine preparation of malignant tumor and preparation method thereof.
Background technology
Tumor is the topical manifestations of a class general disease, is the body tissue cell, under different carcinogenic factor long terms, take place a series of over-drastic, the neoplasm that inharmonic hypertrophy forms with unusual differentiation after even carcinogenic factor fails, still continues undue growth.Its profile often shows as lump, is generally optimum and pernicious two kinds.Because the cause of disease of cancer is various, the sick kind differed, and the clinical manifestation multiterminal so pathological change also is very complicated, are not isolated and single.Modern TCM thinks, the nearly imbalance of YIN and YANG of the pathogenesis of cancer, qi depression to blood stasis, hemorrhoid knot are wet poly-, accumulates in the pyretic toxicity, deficiency of qi and blood etc.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of malignant tumor, this Chinese medicine preparation is with blood circulation promoting and blood stasis dispelling, removing toxic substances and promoting subsidence of swelling, the QI invigorating pain relieving, the effect of benefiting QI and nourishing blood, clearing away heat and promoting production of body fluid, strengthening the body resistance, be used for the treatment and the auxiliary treatment of all kinds of malignant tumor such as pharyngeal cancer, hepatocarcinoma, pulmonary carcinoma, gastric cancer, breast carcinoma, uterus carcinoma, to radiotherapy, chemotherapy has potentiation.
The Chinese medicine preparation of treatment malignant tumor of the present invention is to be primary raw material with Herba Hedyotidis Diffusae, Herba Sarcandrae, Herba Scutellariae Barbatae, Rhizoma Corydalis, rhizoma sparganic, Rhizoma Curcumae, Radix Salviae Miltiorrhizae, Radix Ginseng, the Radix Astragali, Ganoderma, Caulis Spatholobi, the Radix Rehmanniae, Fructus Lycii, Radix Trichosanthis, Herba Taraxaci, Radix Sophorae Tonkinensis, Radix Sophorae Flavescentis, Radix Glycyrrhizae, be prepared from by following steps: raw material is prepared, the Chinese medicine preparation preparation, finished product processing, packing, check.In above preparation method, the weight portion of wherein used raw material is as follows: Herba Hedyotidis Diffusae 400-800, Herba Sarcandrae 300-700, Herba Scutellariae Barbatae 250-600, Rhizoma Corydalis 280-500, rhizoma sparganic 170-280, Rhizoma Curcumae 200-300, Radix Salviae Miltiorrhizae 170-500, Radix Ginseng 70-120, Radix Astragali 300-450, Ganoderma 100-150, Caulis Spatholobi 200-300, Radix Rehmanniae 200-300, Fructus Lycii 100-150, Radix Trichosanthis 200-280, Herba Taraxaci 200-280, Radix Sophorae Tonkinensis 200-280, Radix Sophorae Flavescentis 200-300, Radix Glycyrrhizae 50-80.Preferred weight portion is as follows: Herba Hedyotidis Diffusae 720, Herba Sarcandrae 600, Herba Scutellariae Barbatae 480, Rhizoma Corydalis 360, rhizoma sparganic 240, Rhizoma Curcumae 240, Radix Salviae Miltiorrhizae 240, Radix Ginseng 96, the Radix Astragali 360, Ganoderma 120, Caulis Spatholobi 240, the Radix Rehmanniae 240, Fructus Lycii 120, Radix Trichosanthis 240, Herba Taraxaci 240, Radix Sophorae Tonkinensis 240, Radix Sophorae Flavescentis 240, Radix Glycyrrhizae 60.
The present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of malignant tumor, and this method may further comprise the steps:
A, raw material are prepared:
(1) get rhizoma sparganic, Rhizoma Curcumae is ground into coarse powder, and is standby;
(2) get Herba Hedyotidis Diffusae, Herba Sarcandrae, Herba Scutellariae Barbatae, Herba Taraxaci, the Radix Rehmanniae, Caulis Spatholobi, Radix Glycyrrhizae mixing, standby;
(3) get the Radix Astragali, Ganoderma, Fructus Lycii, variola mixing, standby;
(4) get Radix Sophorae Tonkinensis, Radix Sophorae Flavescentis, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Radix Ginseng mixing, standby.
B, Chinese medicine preparation preparation:
(1) with the rhizoma sparganic of A, (1), the Rhizoma Curcumae coarse powder add 6 times water logging bubble after 1 hour with vapor distillation 2 hours, divide and get volatile oil, distillate is standby, medicinal residues are standby;
(2) the interior B of adding of medical herbs Herba Hedyotidis Diffusae, Herba Sarcandrae, Herba Scutellariae Barbatae, Herba Taraxaci, the Radix Rehmanniae, Caulis Spatholobi, Radix Glycyrrhizae of A, (2), the medicinal residues of (1) are mixed, the decocting that adds 10 times boiled 1 hour, decocting liquid separates with medicinal residues, triplicate, collecting decoction, filter, filtrate and B, (1) distillate merge, and are concentrated into the clear paste of relative density 1.10-1.15 (60 ℃), add ethanol and make that to contain the alcohol amount be 50%, stirred evenly, leave standstill 12 hours, get supernatant liquid filtering, reclaim ethanol, concentrate, be dried to cream, it is standby to be ground into fine powder;
(3) decocting that the medical herbs Radix Astragali, Ganoderma, Fructus Lycii, the Radix Trichosanthis four Chinese medicine of A, (3) is added 12 times boils, and each 2 hours, decocting liquid separated with medicinal residues, decocted repeatedly three times, waste merges three times decocting liquid, filters, filtrate concentrates, and is dried to cream, and it is standby to be ground into fine powder;
(4) with in the medical herbs Radix Sophorae Tonkinensis of A, (4), Radix Sophorae Flavescentis, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, the Radix Ginseng five kinds of Chinese medicine, add 70% soak with ethanol 1 hour, reflux and repeat to extract three times (7,7,7 times), each 1 hour, merge extractive liquid, filtered, filtrate recycling ethanol concentrates, and is dried to dried cream, and it is standby to be ground into fine powder;
C, finished product processing, packing, check:
(1) capsule:
With B, (2), B, (3), the fine powder of B, (4) preparation merges, and mixes, and granulates, and spray adds B, (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, and moistening, to sterilize, incapsulate, test inspection qualified, is finished product.
(2) pill:
With B, (2), B, (3), the fine powder of B, (4) preparation merges, and mixes, makes pill, and spray adds B, (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, moistening, the close ball of sterilizing, pack into, is up to the standards, and is finished product.
(3) tablet:
With B, (2), B, (3), the fine powder of B, (4) preparation merges, and mixes, makes tablet, and spray adds B, (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, moistening, the medicine bottle of sterilizing, pack into, is up to the standards, and is finished product.
(4) powder:
With B, (2), B, (3), the fine powder of B, (4) preparation merges, and mixes, makes powder, and spray adds B, (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, moistening, the packaging bag of sterilizing, pack into, is up to the standards, and is finished product.
The invention is not restricted to above-mentioned capsule, pill, tablet, powder, also comprise oral liquid etc., said dosage form on promptly any pharmaceutics.
Preferable methods of the present invention may further comprise the steps:
A, raw material are prepared:
(1) get rhizoma sparganic 240g, Rhizoma Curcumae 240g is ground into coarse powder, and is standby;
(2) get Herba Hedyotidis Diffusae 720g, Herba Sarcandrae 600g, Herba Scutellariae Barbatae 480g, Herba Taraxaci 240g, Radix Rehmanniae 240g, Caulis Spatholobi 240g, Radix Glycyrrhizae 60g mixing, standby;
(3) get Radix Astragali 360g, Ganoderma 120g, Fructus Lycii 120g, Radix Trichosanthis 240g mixing, standby;
(4) get Radix Sophorae Tonkinensis 240g, Radix Sophorae Flavescentis 240g, Rhizoma Corydalis 360g, Radix Salviae Miltiorrhizae 240g, Radix Ginseng 96g mixing, standby.
B, Chinese medicine preparation preparation:
(1) coarse powder of rhizoma sparganic 240g, the Rhizoma Curcumae 240g of A, (1) is amounted to 480g and add water 2880g and soak after 1 hour with vapor distillation 2 hours, divide and get volatile oil, distillate is standby, and medicinal residues are standby;
(2) the interior B of adding of medical herbs Herba Hedyotidis Diffusae 720g, Herba Sarcandrae 600g, Herba Scutellariae Barbatae 480g, Herba Taraxaci 240g, Radix Rehmanniae 240g, Caulis Spatholobi 240g, Radix Glycyrrhizae 60g of A, (2), the medicinal residues of (1) are mixed, adding water 32kg decocted 1 hour, decocting liquid separates with medicinal residues, triplicate, collecting decoction, filter, filtrate and B, (1) distillate merge, the clear paste that is concentrated into relative density 1.10-1.15 (60 ℃) adds ethanol makes that to contain the alcohol amount be 50%, stirs evenly, leaves standstill 12 hours, gets supernatant liquid filtering, reclaim ethanol, concentrate, be dried to cream, it is standby to be ground into fine powder;
(3) medical herbs Radix Astragali 360g, Ganoderma 120g, Fructus Lycii 120g, the Radix Trichosanthis 240g four Chinese medicine with A, (3) adds water 10kg decoction 2 hours, and decocting liquid separates with medicinal residues, decocts repeatedly three times, waste merges three times decocting liquid, filters, filtrate concentrates, and is dried to cream, and it is standby to be ground into fine powder;
(4) medical herbs Radix Sophorae Tonkinensis 240g, Radix Sophorae Flavescentis 240g, Rhizoma Corydalis 360g, Radix Salviae Miltiorrhizae 240g, the Radix Ginseng 96g five kinds of Chinese medicine with A, (4) adds 70% ethanol 8.3kg immersion 1 hour, backflow repeats to extract three times, each 1 hour, merge extractive liquid,, filter, filtrate recycling ethanol concentrates, be dried to dried cream, it is standby to be ground into fine powder.
C, finished product processing, packing, check:
(1) capsule:
With B, (2), B, (3), the fine powder of B, (4) preparation merges, and mixes, and granulates, and spray adds B, (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, and moistening, to sterilize, incapsulate, test inspection qualified, is finished product.
(2) pill:
With B, (2), B, (3), the fine powder of B, (4) preparation merges, and mixes, makes pill, and spray adds B, (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, moistening, the close ball of sterilizing, pack into, is up to the standards, and is finished product.
(3) tablet:
With B, (2), B, (3), the fine powder of B, (4) preparation merges, and mixes, makes tablet, and spray adds B, (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, moistening, the medicine bottle of sterilizing, pack into, is up to the standards, and is finished product.
(4) powder:
With B, (2), B, (3), the fine powder of B, (4) preparation merges, and mixes, makes powder, and spray adds B, (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, moistening, the packaging bag of sterilizing, pack into, is up to the standards, and is finished product.
The invention is not restricted to above-mentioned capsule, pill, tablet, powder, also comprise oral liquid etc., said dosage form on promptly any pharmaceutics.
The Chinese medicine preparation of above-mentioned treatment malignant tumor, suggestion adult dosage, every day three times, each 2g, 30 is a course of treatment.
The invention provides a kind of compatibility foundation for the treatment of the Chinese medicine preparation of malignant tumor.
The present invention is that the treatment and the auxiliary treatment of planting cancer more than the blood stasis syndrome are established, and is monarch drug with Herba Hedyotidis Diffusae, Herba Sarcandrae; Herba Scutellariae Barbatae, Rhizoma Corydalis, rhizoma sparganic, Rhizoma Curcumae, Radix Salviae Miltiorrhizae are ministerial drug; Radix Ginseng, the Radix Astragali, Ganoderma, Caulis Spatholobi, the Radix Rehmanniae, Fructus Lycii, Radix Trichosanthis, Herba Taraxaci, Radix Sophorae Tonkinensis, Radix Sophorae Flavescentis are adjuvant drug; Radix Glycyrrhizae is for making.Become blood circulation promoting and blood stasis dispelling altogether, removing toxic substances and promoting subsidence of swelling, the agent of benefiting QI and nourishing blood.The Fang Zhongbai Herba Hedyotidis Diffusae, bitter in the mouth, sweet, cold in nature, the heat clearing away dissipating blood stasis is arranged, the merit of removing toxic substances and promoting subsidence of swelling cures mainly ulcer sores, diseases such as scrofula, existing extensively trying out in the various cancers of treatment.Herba Sarcandrae, the bitter in the mouth suffering, property is flat, heat-clearing and toxic substances removing is arranged, blood circulation promoting and blood stasis dispelling, the merit of reducing swelling and alleviating pain; The Guangxi carbuncle and ulcer toxic swelling that is usually used among the people, diseases such as traumatic injury, Guangxi " Luchuan book on Chinese herbal medicine " said: " synthetism, removing mass is controlled injury and bone fracture ", with it promoting the circulation of blood removing mass is arranged, so the merit of blood stasis removing pain relieving is also; " practical oncology " carried it and is used for controlling of digestive tract adenocarcinoma.Two medicines share, its blood circulation promoting and blood stasis dispelling, and the merit of removing toxic substances and promoting subsidence of swelling is more outstanding, is used for the treatment of the cancer of blood stasis, and its power is stronger, so be the monarch drug in the side altogether.
Herba Scutellariae Barbatae, acrid in the mouth, little hardship, cool in nature, heat-clearing and toxic substances removing is arranged, the merit of promoting blood circulation to remove blood stasis pain relieving is used for the pyretic toxicity carbuncle, diseases such as cirrhotic ascites; Closely also be used for the treatment of multiple cancers such as gastric cancer.Rhizoma Corydalis, bitter in the mouth, little suffering, warm in nature, blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain.Rhizoma sparganic, the bitter in the mouth suffering, property is flat, function removing blood stasis, circulation of qi promoting, removing food stagnancy, pain relieving; Rhizoma Curcumae, the bitter in the mouth suffering, warm in nature, the circulation of qi promoting of function removing blood stasis, the removing food stagnancy pain relieving, two medicine mutual reinforcements between are usefulness, bring out the best in each other, the power of its removing blood stasis circulation of qi promoting is stronger, is usually used in the card of the lump in the abdomen of stagnation of QI and blood.Radix Salviae Miltiorrhizae, bitter in the mouth, cold nature, function blood circulation promoting and blood stasis dispelling.More than five medicines share, its blood circulation promoting and blood stasis dispelling, the effect of promoting the circulation of QI to relieve pain heightens, to strengthen the monarch drug blood circulation promoting and blood stasis dispelling, the effect of removing toxic substances and promoting subsidence of swelling is the ministerial drug in the side altogether.
The one-tenth person of lid cancer, positive QI-insufficiency, then pathogen is crouched it, so-called " institute of heresy gathers, and its gas must be empty " person also, so in square again with the sweet tepor of Radix Ginseng, air making-up and spleen enlivening; The sweet tepor of the Radix Astragali, replenishing QI to invigorate the spleen, promoting pus discharge and tissue regeneration strengthening; Ganoderma sweet flat, replenishing QI to invigorate the spleen, three medicines share, then the merit of replenishing QI to invigorate the spleen is stronger, in order to strengthening the body resistance with eliminating evil.Enrich blood with the Caulis Spatholobi promoting the circulation of blood again; The Radix Rehmanniae, nourishing YIN and benefiting blood; The Radix Trichosanthis clearing away heat and promoting production of body fluid quenches the thirst, closely has in order to the curing cancers person, and Fructus Lycii, nourishing YIN and supplementing blood, promoting the production of body fluid to quench thirst, four medicines share it, nourishing YIN and supplementing blood is arranged, nourish blood, and the merit of promoting the production of body fluid to quench thirst also becomes the merit of strengthening vital QI to eliminate pathogenic factors.The lid blood stasis with the passing of time can heat-transformation, thus be aided with the product that heat clearing away is separated again in the side, Herba Taraxaci, hardship is sweet cold in nature, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Radix Sophorae Tonkinensis, bitter cold, eliminating fire and detoxication, clearing throat, reducing swelling and alleviating pain, and nearly person tries out the treatment in cancer; Radix Sophorae Flavescentis, bitter cold, heat clearing and damp drying, the detoxifcation parasite killing, three medicines share, and become the merit of heat-clearing and toxic substances removing altogether, with the heresy of clear its pyretic toxicity.More than each medicine close and use it, can help and help all medicines of the monarch and his subjects to control the merit of cancer, so be the adjuvant drug in the side altogether.
Radix Glycyrrhizae, sweet flat, coordinating the actions of various ingredients in a prescription is the messenger drug in the side.
More than all medicines share, play the cancer of dispelling of invigorating blood circulation altogether, removing toxic substances and promoting subsidence of swelling, the merit of benefiting QI and nourishing blood.Be used for all kinds of property oncotherapys such as nasopharyngeal carcinoma, hepatocarcinoma, pulmonary carcinoma, breast carcinoma, uterus carcinoma of syndrome of blood stasis, to therapy, chemotherapy has potentiation.
From above prescription, it has only with prescription just to meet the dialectical traditional Chinese medical science principle of controlling of executing with single completely different with Herba indigoferae Pseudotinctoriae treating malignant tumor on probation, and what just meet eliminating pathogenic factor for supporting vital QI executes method of treatment then, just can reach treating both the principal and secondary aspects of a disease, consolidates the effect of radically reforming.
The present invention also provides a kind of relevant document ancient books, experience or modern relevant this kind research etc. for the treatment of the malignant tumor Chinese medicine preparation:
(1), BAIYAO Herba Hedyotidis Diffusae: for the Maguireothamnus speciosus Agkistrodon is given up careless Hedyotis diffusawilld.Dry herb.Bitter in the mouth, sweet, cold in nature, the heat clearing away dissipating blood stasis is arranged, the merit of removing toxic substances and promoting subsidence of swelling cures mainly ulcer sores, and diseases such as scrofula now are widely used in the various cancers of treatment.The document ancient books: this product is a medical herbs commonly used among the people in modern age, and the successive dynasties book on Chinese herbal medicine is not seen record, and in the modern document, " Guangxi Chinese medicinal herbal " carries: " control infantile malnutrition, venom, cancerous protuberance." " the south of Fujian Province traditional herbal medicine " carry: " heat-clearing and toxic substances removing, anti-inflammatory analgetic.", " Quanzhou book on Chinese herbal medicine " carries " heat clearing away dissipating blood stasis, eliminating carbuncle detoxifcation.Control carbuncle skin ulcer scrofula, scrofula.Again can the lung heat clearing fire, eliminating the pathogens from the lung heat.Control the lung-heat dyspnea with rapid and short breath, cough against uncomfortable in chest.", carry " medicinal plants register " [2]: " whole plant for medical use, sweet in the mouth, light, cool in nature.Heat-clearing and toxic substances removing is arranged, antiinflammatory diuretic effect.Cure mainly acute appendicitis, enteritis, dysentery, cancerous protuberance, furuncle etc.", carry " folks of china SHENGCAO medicine primary colors collection of illustrative plates " [3]: " sweet, light, cool, heat-clearing and toxic substances removing, diuresis is swollen clearly.Be used for appendicitis, hepatitis, acute nephritis, urinary tract infection, tonsillitis, infantile malnutrition, venom, sore swollen toxin, traumatic injury stasis of blood pain.Consumption 30-60g." " Guangxi book on Chinese herbal medicine a collection of selected materials " [4] carry: " slightly sweet flavor, cool in nature.Clearing away heat and promoting diuresis, promoting blood circulation and detoxication.Be used for cancerous protuberance, encephalitis B, appendicitis, infantile malnutrition.", " Guangxi natural resources of Chinese medicinal materials register " carries: " be used for laryngopharynx swelling and pain, cough due to lung-heat, dysentery, appendicitis, hepatitis, pelvic inflammatory disease, adnexitis, venom, cancer.”
(2) Herba Sarcandrae is the dry herb of Chloranthaceae plant plait Corallium Japonicum Kishinouye Sarcandraglabra (Thunb.) Nakai.Slightly warm in nature, bitter in the mouth, suffering.The tool anti-inflammation, dispelling wind and removing obstruction in the collateral, the merit of blood circulation promoting and dispersing pathogen accumulation is used for pneumonia, cholecystitis, appendicitis, acute gastroenteritis, acute cellulitis, rheumatic arthralgia, injury from falling down, tumor.The document ancient books: this product is not seen record in the book on Chinese herbal medicine in early days, Tang's " Newly Revised Canon of Materia Medica " is loaded with Ramulus Sambuci Williamsii, main folding is hindered, reuniting the fractured tendons and bones, but the height of tree reaches 1-2 zhang is permitted [15], and different with this product, " Zhiwu Mingshi Tukao " is loaded with Ramulus Sambuci Williamsii, be used for synthetism [16], " Chinese medicinal plants will " thinks promptly be this product [17].What the relevant books of the Chinese herbal medicine of Chu Baning had in recent years is also on the books to this product, and this product generally is used for antiinflammatory, and it is swollen to loose, pain relieving and traumatic injury." medicinal plants register " carries " medicinal Herb.Bitter in the mouth, little suffering, property is flat.Have dispel wind and remove dampness, the effect of reducing swelling and alleviating pain, relaxing muscles and tendons and activating QI and blood in the collateral.Control injury and bone fracture, acute mastitis, innominate toxic swelling, acute appendicitis, pneumonia." [18] " folks of china SHENGCAO medicine primary colors collection of illustrative plates " carry: " bitter, hot, tepor.Anti-inflammation, dispelling wind and removing obstruction in the collateral, blood circulation promoting and dispersing pathogen accumulation.Be used for pneumonia, appendicitis, acute cellulitis, rheumatic arthralgia, injury from falling down, tumor.Consumption 10-30g." [19]; " Guangxi natural resources of Chinese medicinal materials register " carries: " be used for cold, fever, pneumonia, enteritis, dysentery, dyspepsia, rheumatic ostalgia, traumatic injury, appendicitis, carbuncle sore tumour, tumor." [20]; " national Chinese herbal medicine compilation " carries: " hot, bitter, flat.Slightly poisonous.Heat-clearing and toxic substances removing, the synthetism of stimulating the menstrual flow.Be used for influenza, epidemic encephalitis type B, pharyngolaryngitis, infantile pneumonia, lobar pneumonia, bacillary dysentery, acute appendicitis, sore swollen toxin, fracture, traumatic injury, rheumatic arthralgia, cancer.Consumption 9-15g." [21]; " Guangxi book on Chinese herbal medicine a collection of selected materials " carries: " the little suffering of bitter in the mouth, property is flat.Expelling wind and activating blood circulation, dissipating blood stasis for subsidence of swelling.”[22]。
(3), Herba Scutellariae Barbatae: be the dry herb of labiate BANJILIAN flower Scatellaria barbata.D.Don.Acrid in the mouth cold in nature, hardship, return lung, liver, kidney channel.The tool heat-clearing and toxic substances removing, the merit of the diuresis of reducing phlegm is used for furuncle swelling toxin, laryngopharynx swelling and pain, the poisonous snake flood dragon hinders, and falls and pounces on the pain of injury, edema, jaundice.The document ancient books: this stroke of successive dynasties do not seen and recorded, and sporadically appears in the document in modern age: " Nanjing medicinal herbs among the people " carry: " removing blood stasis latus rectum.", " the Guangxi medicine is planted figure will " carries: " antiinflammatory, dissipating blood stasis, hemostasis.Control traumatic injury and hinder dysentery." " Nanning City's medicine will " carry: " detumescence, pain relieving.Control traumatic injury, weapons are hindered, skin infection.", " Chinese herbal medicine handbook commonly used is carried: " heat-clearing and toxic substances removing in Guangzhou army.Control cancer and see the effect of improving symptom.", " herbtherapy handbook commonly used: " treatment of esophagus cancer, gastric cancer, uterus carcinoma.”
(4) Rhizoma Corydalis: be the dry tuber of papaveraceae plant corydalis Corydali yanhusuo W.T.Wang.Acrid in the mouth warm in nature, hardship are returned liver, spleen channel.Tool is invigorated blood circulation, promoting the circulation of QI, and the merit of pain relieving is used for the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.The document ancient books: Compendium of Material Medica is carried: " stagnation of QI in the promoting the circulation of blood of Rhizoma Corydalis energy, stasis in the gas, thus all pains about curing mainly all over the body, among using, simply fantastic." " Bencao Jingshu " carry: " Rhizoma Corydalis, Wen Zeneng and smooth and freely then gas is capable; Xin Zeneng profit and wandering away, the blood of wandering away is then lived, blood is lived, and then gas is capable, thus can main removing blood stasis and puerperal all cause of disease blood person of doing.”。" book on Chinese herbal medicine justice " carries: " Rhizoma Corydalis, though be the product of the broken promoting the circulation of blood that stagnates, right feelings still belong to gentle; very not fierce ... and hold concurrently can circulation of qi promoting, specially is not good in removing blood stasis with potent drugs, so can control the disease that inside and outside QI and blood is not up and down declared; the logical eliminating stagnation that stagnates, all diseases of main all liver gastrointestinal abdomens, benefit break through in the admittance towards and product also.”
(5) rhizoma sparganic: be the dry tuber of Sparganiaceae plant rhizoma scirpi Sparganium stoloniferumBuch.-Ham..The flat acrid in the mouth of property, hardship are returned liver, spleen channel.The circulation of qi promoting of tool removing blood stasis, the merit of removing food stagnancy pain relieving is used for the lump in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain.The document ancient books: Materia Medica of Decoction carries: " Liver Channel blood system medicine also for rhizoma sparganic, the gas in the removing blood stasis.It is hard to control long-pending piece skin ulcer, be hard masses should be resolved gradually also.", Compendium of Material Medica meaning: " rhizoma sparganic can relieving stagnant and resolving masses, so can control all diseases, its merit can be bordering on Rhizoma Cyperi and power is high.", " book on Chinese herbal medicine is through vegetables " carry: " rhizoma sparganic is then controlled blood from the blood medicine, then controls gas from the gas medicine.Old addiction lump in the abdomen caking does not have due to the blood stasis of can't help, depressed, food stop, and hardship can be rushed down and hot can loosing, sweet energy and and go into spleen, blood pertaining to YIN and tangible amasss also so this can control the tangible heavily fortified point of all stagnations of condensing.... it can rush down vital qi, and true deficiency of vital energy person does not use ... event is all in order to food stagnation removing, must support the power of Radix Ginseng, Radix Paeoniae, Radix Rehmanniae, then can not have fraud.”。" Records of Tradition Chinese and Western Medicine in Combination " carries: " the rhizoma sparganic abnormal smells from the patient is all light, and little have a hot meaning ... be the key medicine of blood stasis dispelling ... the power of its circulation of qi promoting; can control trusted subordinate's pain again, the side of body expand painful down, all diseases of all blood clotting stagnation of QIs; if with ginseng, art, all medicines of stilbene and usefulness, the feed of whetting the appetite greatly, accent blood and blood.”。
(6) Rhizoma Curcumae: be the dry rhizome of zingiberaceous plant Rhizoma Curcumae Curcuma phaeocaulis Valeton, Guangxi zedoary Curcuma kwangsiensis S.G.Lee et C.F.Liang or RADIX CURCUMAE Curcumawenyujin Y.H.Chen et C.Ling.Acrid in the mouth warm in nature, hardship, return liver, spleen channel.Tool circulation of qi promoting removing blood stasis, the merit of removing food stagnancy pain relieving is used for the lump in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.The document ancient books: " Bencao Tujing " carries: " Rhizoma Curcumae ... modern doctor family stagnates and gathers all gas is key medicine.", Materia Medica of Decoction carries Rhizoma Curcumae: " darkish complexion, the blood in the dispelling the stagnated QI though let out Ji, also can be enriched blood.", " Bencao Jingshu " carries: " ... the cardiac and abdominal pain person, non-QI and blood must not be in harmonious proportion, and promptly is among the evil visitor due to Jiao, and the attacked by pestiferous factors chronic infectious disease is disobedient, and all by the gas incongruity, internal organs are stopped up and are stagnated, imbalance of YIN and YANG, then epidemic disease scrofula chronic infectious disease is disobedient is able to it.... gas is known strong, and the energy regulating QI is sensible, the then evil nothing visitor of institute of key profit and diffusing.
(7) Radix Salviae Miltiorrhizae: be the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..The cold nature bitter in the mouth, GUIXIN, Liver Channel.Stasis-dispelling and pain-killing is arranged, promoting blood circulation to restore menstrual flow.The clear away heart-fire effect of relieving restlessness is used for menoxenia, the amenorrhea dysmenorrhea, and lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.The document ancient books: the beginning is stated from " legendary god of farming village grass through ", call its " bitter in the mouth, be slightly cold, main trusted subordinate's pathogen, borborygmus are faint as leak water, cold and heat gather, broken disease is removed abdominal mass, ends stuffy sensation with restlessness, QI invigorating.", " Mingyi Bielu " carries that " Radix Salviae Miltiorrhizae is nontoxic.Main nourishing blood gone trusted subordinate's obstinate disease, stagnation of QI, and stiffness along the spinal column, foot numbness, exorcising stays heat, obeys sharp people for a long time.", " book on Chinese herbal medicine converges and says ": " Radix Salviae Miltiorrhizae is apt to control blood system, eliminating blood stasis to promote regeneration of blood, and regulating menstruation is along the feeling pulse medicine also.”
(8) Radix Ginseng: for Araliaceae Radix Ginseng Panax ginseng C.A.Mey. has dry root.The flat sweet in the mouth of property, little hardship are returned spleen, lung, heart channel.The tool strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, and the merit of calming the nerves is used for weak body and prostration, the cold extremities faint pulse, insufficiency of the spleen lack of appetite, cough and asthma due to lung deficiency, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, and prolonged illness is empty wins, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.The document ancient books: the beginning is stated from Shennong's Herbal, meaning: " main tonifying five ZANG-organs peace spirit, spasmolytic is throbbed with fear, and removes pathogen, makes eye bright, happy Fructus Alpiniae Oxyphyllae, clothes are made light of one's life by commiting suicide and are prolonged life for a long time." " Mingyi Bielu " carry: " and tepor, nontoxic, treat the intestinal cold in the stomach, trusted subordinate's drum pain, feeling of fullness and discomfort in the hypochondrium, cholera is told contrary, in the accent, only quenches one's thirst, promoting blood circulation, broken hard long-pending, make us not forgetting.", " property of medicine book on Chinese herbal medicine " meaning: " the deficient abundant expectoration of Radix Ginseng master five kinds of strain and seven kinds of impairment, preventing or arresting vomiting sound of vomiting tonifying five ZANG-organs six internal organs are kept god among the guarantor, and the expectorant in the heart that disappears is controlled pulmonary fistula and epilepsy disease, and cold air is contrary last.", Compendium of Material Medica is carried: " control all deficiency syndrome of male woman, the heating spontaneous perspiration, the dizzy regurgitation of having a headache is told food and is cut off from malaria, and slide and rush down chronic dysentery, frequent micturition, dripping, overstrain internal injury apoplexy, heatstroke, fistula numbness, haematemesis, hemoptysis, hematochezia, stranguria with blood, metrorrhagia, tire all diseases in preceding puerperal.”。
(9) Radix Astragali: be the dry root of leguminous plant Radix Astagali Astragulus membranaceus (Fisch.) Bge.Varmongholicus (Bge.) Hsiao or Radix Astragali Astragulus membranaceus (Fisch.) Bge..Sweet in the mouth warm in nature is returned lung, spleen channel, function invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.It is weak to be used for the deficiency of vital energy, anorexia and loose stool, and sinking of QI of middle-JIAO, the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and stain is not held back for a long time, blood deficiency and yellow complexion, interior-heat is quenched one's thirst; Chronic nephritis, albuminuria, diabetes.The document ancient books: the beginning is stated from Shennong's Herbal, and " main carbuncle loses skin ulcer to meaning for a long time for the Radix Astragali, sweet in the mouth, tepor, evacuation of pus pain relieving, strong wind leprosy disease, five hemorrhoid scrofula.Refreshing empty, children's's all kinds of diseases and ailments.", " Mingyi Bielu " carries: " Radix Astragali, nontoxic, cure mainly the dirty ailment said due to cold or exposure gas of married woman's, by stagnant blood between the five internal organs, it is deficient to mend the husband, and five kinds of over strain is won thin, quenches the thirst, the stomachache dysentery, QI invigorating, Li Yin gas, it is cold to give birth to the plain boiled water person, mends.", the Materia Medica of Decoction meaning: " Radix Astragali is controlled deficiency of vital energy night sweat and spontaneous perspiration, and promptly this medicine of skin table is controlled pain in the skin again, then medicine administered to bring out the cold is controlled spitting of blood again as can be known, gentle taste, be for Central Region medicine also, the cold chi pulse that cures the wound again is unlikely, and the dirty vigour of the kidney invigorating is the lining medicine again, is the medicine of the inside and outside three warmers of upper, middle and lower.", " book on Chinese herbal medicine is just " meaning: " Radix Astragali, soil in the tonification, the replenishing vital QI with drugs of warm nature taste, all deficiency of QI in middle-JIAO, spleen soil is weak, and sagging person is the most suitable for clearing heat in QI system, and its through people's skin table muscle admittedly escort sun, enriches table and divides tool its speciality.So all diseases of exterior deficiency, the most refreshing agent.”
(10) Ganoderma: be Polyporaceae plant Ganoderma Ganoderma lucidum (Leyss.ex Fx.) Karst or Ganoderma Ganoderma sinense Zhao, the dry sporophore of Xu et Zhang.Warm in nature lightly seasoned, return lung, liver, the heart, kidney four warps.The tool tranquilizing by nourishing the heart, invigorating qi and benefiting blood, the merit of relieving cough and asthma.Be used for the neurasthenia, dizzy insomnia, dyspepsia; Hypertension, coronary heart disease, bronchitis, chronic hepatitis, asthma, pneumosilicosis, rheumatic arthritis.The document ancient books: the beginning is stated from Shennong's Herbal: " main deaf, god is protected, beneficial vital essence, hard muscle flesh, good color in sharp joint.”
(11) Caulis Spatholobi: be the dry rattan of leguminous plant spatholobus suberectus Spatholobus suberectys Dunn.Bitter in the mouth warm in nature, sweet is returned liver, kidney channel, and tool is enriched blood, and invigorates blood circulation, and the merit of collateral dredging is used for menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.The document ancient books: Compendium of Material Medica is carried: " invigorate blood circulation warm waist knee joint, paralysis.", " book on Chinese herbal medicine is new again " carries: " the dry stomach of invigorating middle warmer.”。" 1 new ginseng " " pained little sweet, blood stasis removing blood, tissue regeneration promoting blood, fluent passages through which vital energy circulates.Control summer filthy infection, migratory arthralgia disease.
(12) Radix Rehmanniae: be the fresh or dry tuber of scrophulariaceae rehmannia glutinosa plant Rehmannia glutinosa Libosch..Sweet in the mouth cold in nature, GUIXIN, liver, kidney channel, the tool clearing away heat and cooling blood, yin nourishing, the merit of promoting the production of body fluid is used for calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, the hectic fever due to YIN-deficiency consumptive fever, interior brimful of tears quenching one's thirst spitted blood, and epistaxis is sent out the speckle dermexanthesis.The document ancient books: " book on Chinese herbal medicine newly organized " carries: " Radix Rehmanniae, the fire of cool women's head-ornaments, the heat of lung heat clearing liver, the absurd row of warm blood, or spit blood, or epistaxis ... ... ", " book on Chinese herbal medicine converge speech " carries: " Radix Rehmanniae is the kidney invigorating key medicine, and tonifying YIN is top grade, so that removing heat from blood is enriched blood is meritorious.”
(13) Radix Trichosanthis: be the dry root of cucurbitaceous plant Fructus Trichosanthis Trichosanthes kirilowii Maxim. or trichosanthes rosthornii Harms Trichosanthes rosthornii Herms.Cold nature, sweet in the mouth, little hardship attach to the lung and stomach meridians.The tool clearing away heat and promoting production of body fluid, the merit of detumescence and apocenosis is used for the calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.The document ancient books: Compendium of Material Medica is carried: " acid can be promoted the production of body fluid for radices trichosanthis, sweet and slightly bitter taste acid, so the profit of quenching the thirst is withered, little bitter pathogenic fire reducing does not sweetly injure one's stomach.", " book on Chinese herbal medicine converge with speech " carries: " Radix Trichosanthis, it is hot and suffocating to move back the five internal organs, lung-fire is contained and the pharyngeal swelling sore throat, and spleen-fire is contained and the dispute tooth is swollen, and phlegm-fire is contained and cough is not peaceful, the migratory arthralgia caused by wind if the side of body of liver-fire expands, the hectic fever due to YIN-deficiency dysphoria with smothery sensation of kidney fire, or carbuncle has been burst routed, and pyretic toxicity does not loose, or five cellulitis yellow skin and eyes, and if little water is if drench puckery, is due to all burning hot pent-up, only phlegm-fire falls in this agent energy relieving stagnation.And can control it, and its property is sweet cold again, and kind can controlling yearningly controlled excessive thirst from tonic, is to control thirsty key medicine also.", " herbal classic is met former " carries: " radices trichosanthis falls every last heat-phlegm, moistens excessive thirst in the heart, expectorant fanaticism when removing, and the wine of dispelling illness is wet yellow, controls the carbuncle and ulcer removing toxic substances and promoting pus discharge.”。
(14) Fructus Lycii: be the dry mature fruit of plant of Solanaceae lycium barbarum Lycium barbarum L..The flat sweet in the mouth of property is returned liver, kidney channel.The tool nourishing the liver and kidney, the merit of replenishing vital essence to improve eyesight is used for the asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, blurred vision is not clear.The document ancient books: the beginning is stated from Shennong's Herbal, call its " pathogens in main five pine for quenching one's thirst, solid numbness rheumatism, clothes for a long time, hard muscles and bones, it is not old to make light of one's life by commiting suicide, summer-heat resists cold.", " Mingyi Bielu " carries: " lower breast side of body gas, exopathogenic heat headache, the internal injury Da Lao suction of hissing, reinforcing YIN-essence, sharp intestine and small intestine.Nourishing the essence and strengthening QI, prosperous and powerful vagina.", " book on Chinese herbal medicine is stated " carries: " treat the liver-wind blood deficiency, the confused nebula of eye red sufferings.It is dizzy to control apoplexy, and asthenia is allly seen blood disorder, cough blood, and flaccidity with cold limbs, contraction, diseases due to endogenous heat of ZANG FU organs is hindered dryly, passes out semen reddish and whitish turbid urine, beriberi, the arthroncus of knee.", " herbal outline " said: " spermatogenesis is supporing yang, the bone and muscle strengthening of tonify deficiency labor, dispelling pathogenic wind for improving eyesight for lung moistening liver heat removing, nourishing kidney benefit unit.”。
(15) Herba Taraxaci: be feverfew Herba Taraxaci Taraxacum mongolicumHand.---Hazz., or alkali ground Herba Taraxaci Traxacum sinicum kitag or belong to the dry herbs of several plants together.Cold in nature, bitter in the mouth, sweet is returned liver, the stomach warp, and the tool heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, the merit of inducing diuresis for treating stranguria syndrome is used for furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, jaundice due to damp-heat, the puckery pain of pyretic stranguria.
(16) Radix Sophorae Tonkinensis: be leguminous plant Sophora tonkinensis Gagnep. Sphora tonkinensis Gapnep, dry root and rhizome.Bitter in the mouth cold in nature, poisonous, return lung, the stomach warp.The tool heat-clearing and toxic substances removing, the merit of detumescence sore-throat relieving is used for fire-toxin and pents up, laryngopharynx swelling and pain.The document ancient books: " book on Chinese herbal medicine converge with speech " carries: " Radix Sophorae Tonkinensis, bitter cold are respectful clearly, the order that must fall, it is kind that to remove the lung stomach hot and suffocating, all sudden and violent sensible heat diseases are cool and detoxify, about the exterior and the interior, do not have show suitable it.", " book on Chinese herbal medicine is looked for the truth " carries: " Radix Sophorae Tonkinensis, lung is protected in the special removing pathogen in the heart of merit, and it is contrary to fall the yin channel fire, separates laryngopharynx swelling and pain first key medicine.", " Bencao Jingshu " carries: " Radix Sophorae Tonkinensis, so sweet and malicious, so cold heat extraction, all poisonous weeds heat in the heart must be hot, poor gas, the flavor of sweetness and bitterness, then all poison are explained by oneself, so be the medicine on the heat that disappears that detoxifies.All pains must be because of in heat, and malicious analgesic diffusing, then pain is from ending, and skin ulcer swells and disappears certainly.”。
(17) Radix Sophorae Flavescentis: be the dry root of leguminous plant Radix Sophorae Flavescentis SA.Bitter in the mouth cold in nature, GUIXIN, liver, stomach, large intestine, urinary bladder channel.The tool heat clearing and damp drying, parasite killing, the merit of profit is used for hematodiarrhoea, has blood in stool, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy; External treatment trichomonal vaginitis.The document ancient books: the beginning is stated from Shennong's Herbal.Call its " main stagnation of QI in chest and abdomen, lump in the abdomen, jaundice, drowning has the heeltap, relieves oedema or abdominal distension through diuresis or purgation, and removes carbuncle, invigorating middle warmer makes eye bright.", " Mingyi Bielu " carries: " the sedate benefit is smart for nourishing the liver courage, settling five organs, sharp key for a long time, and it is dirty to remove latent heat, quenches the thirst, and sobers up, and yellowish or reddish urine is treated the malignant boil bottom, and flat gastric qi makes us having a liking for food.", " property of medicine opinion " carries: " control pyretic toxicity wind, the irritated skin ulcer of giving birth to of musculus cutaneus, red leprosy eyebrow takes off, and is main drowsiness except that big heat, controls cold type of pain in the abdomen, attacked by pestiferous factors stomachache, it is vexed to remove body, controls the trusted subordinate and gathers.", " the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " removing heat from blood is separated pyretic toxicity, mange, impetigo poison.Treat skin pruritus, blood tinea corporis skin ulcer, naughty white-browed, discharging fresh blood stool is had blood in stool.Pathogenic wind expelling, detumescence poison, expectorant poison.”。More than each medicine close and use it, can help and help all medicines of the monarch and his subjects to control the merit of cancer, so be the adjuvant drug in the side altogether.
(18) Radix Glycyrrhizae: be the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch, Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..The flat sweet in the mouth of property, coordinating the actions of various ingredients in a prescription is the messenger drug in the side, GUIXIN, lung, spleen, stomach warp.The tool invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the merit of coordinating the actions of various ingredients in a prescription is used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction.Carbuncle sore tumefacting virus is alleviated thing toxicity, strong.The document ancient books: the beginning is stated from Shennong's Herbal: " sweet in the mouth, flat.Main vital organs of the human body cold and heat pathogen, hard muscles and bones, longue meat, times power, incised wound is swollen, detoxifcation.", " Mingyi Bielu " carries: " main warming the middle warmer and descending qi, stuffy sensation with restlessness is losed heart, and hinders dirty cough, quench the thirst, qualcomm meridian, sharp vim and vigour are separated hundred poison of drug ....", " property of medicine opinion " carries: " cold type of pain in the main abdomen is controlled infantile convulsion, removes distention and fullness in the abdomen tonification the five internal organs; Make all poison of drug; Support the kidney qi internal injury, make us cloudy not flaccidity; Housewife's human blood drop lumbago; Void and frequent fever add and use it.", " Japan hanako materia medica " carries: " the peace soul is decided soul.Mend five kinds of strain and seven kinds of impairment, all are deficient, palpitation with fear, unhappy, forgetful.Logical nine orifices, sharp hundred arteries and veins, beneficial intensive culture gas, strengthening bone and muscle is separated cold and hot.", " book on Chinese herbal medicine converge with speech " carries: " Radix Glycyrrhizae and middle QI invigorating, the medicine of tonify deficiency detoxifcation also, strengthening the spleen and stomach, the void win of solid middle gas; Association's negative and positive and uncomfortable battalion defend.So control the strain internal injury, deficiency-weakness of spleen-QI, first YANG deficiency, decline of lung-QI, its Gan Wenping mends, and effect and ginseng, stilbene are also also.", Compendium of Material Medica is carried: " sweet flat nontoxic.Feed brothers' 12 warps.Separate infantile carbuncle, infantile convulsion, pathogenic fire reducing pain relieving.”。
The present invention treats the Chinese medicine preparation capsule of malignant tumor, through the institute for drug control, Guangxi, and animal acute toxicity test, test method and result are as follows:
Get 20 of mices (♀ ♂ half and half), the filling stomach was subjected to the reagent thing after taboo was raised (water supply) 14h, and the administration volume is 40ml/kg, and dosage is equivalent to crude drug 164.9g/kg.Situations such as the outward appearance of mice, behavior, breathing, extremity activity, feed, drainage, death in 7 days after the observation administration.Weighed in the 7th day, and observed its body weight gain situation.As a result, mice shows as activity and reduces gradually after the administration, recovers normal activity after 6-10 hour; The visible sepia soft stool of discharging about 10 hours behind the medicine, next day, defecation recovered normal substantially; Thereafter the outward appearance of mice, breathing, extremity activity, feed, drainage etc. there is no obviously unusual in 7 days; The no phenomena of mortality; Body weight 20.1 ± 0.85g before the medicine, the 7th day body weight 25.4 ± 1.45g behind the medicine, rate of body weight gain is 26.5%.
Test shows that the present invention treats the disposable mouse stomach administration of Chinese medicine preparation of malignant tumor, and maximum dosage-feeding is crude drug 164.9g/kg, is with daily dose 130 times of clinical plan.Prompting this product is oral with daily dose by clinical plan to be safe.
The present invention treats the Chinese medicine preparation of malignant tumor, through the institute for drug control, Guangxi, and long-term toxicity test for animals, test method and result are as follows:
Get 160 of rats, standby, divide 4 groups at random.Three groups are given by the dosage of crude drug 6 3.5g/kg, 31.7g/kg, 15.9/kg respectively and are subjected to the reagent thing, and matched group is given ordinary water.Gastric infusion in morning every day once (drug withdrawal on Sunday), the administration volume is 20ml/kg, continuous 26 weeks.The general apparent and toxic reaction situation of rat during the observation administration; Weigh in once weekly.Get 10,15 rats by intraperitoneal injection sodium pentobarbital 40mg/kg anesthesia respectively at 13 weeks of administration, 26 week backs, each group, through the ventral aorta blood sampling do the hematology, blood biochemical is learned and is checked; Cut open and get the part internal organs and weigh, be converted into the organ weights index by the contained organ weights of every 100g body weight; Cut open and get main organs and do naked eyes and histological examination.Each administration group measured value and matched group are compared t check between the work group.Each is organized remaining rat and stops observing the 2 the same method processing in week back.
Conclusion:
Gavage 26 weeks of medicament mixed powder of the present invention continuously for respectively rat by the dosage of crude drug 63.5g/kg 31.7g, kg 15.9g/kg (be respectively clinical usefulness one 50 times, 25 times, 12.5 times), cause other tangible toxic reaction except that having slight increase liver weight when the heavy dose, subtract, increase the genotoxic potential of serum ALP activity and GLu content, there is no with spleen weight; Drug withdrawal does not see after 2 weeks that appearance significantly delays toxic reaction, disappears and the performance of above-mentioned genotoxic potential is basic.Because of small dose group is not seen the tangible toxic reaction of appearance, so can think that this product is safe by clinical plan with using dosage, approach, the course of treatment.
The result of the test for the treatment of cancer drug according to clinical use the present invention shows: this medicine all has better curative effect to various tumors.The a few days sees that promptly tumor patient tumor body obviously dwindles after taking medicine.To advanced carcinoma is painful the persistency analgesic effect arranged.All have no adverse reaction and toxic and side effects after various cancer patients take medicine, all can reach the effect of relief of symptoms life-saving.
From clinical observation, this medicine is not only effective in cure to cancer, and painful to heart strand, and cardiac extra systole has the effect of removing symptom immediately.The apoplexy that causes for cerebrovascular disease (comprising ischemic or hemorrhagic), if the cerebrovascular disease peripheral cell organize necrosis does not appear as yet and before, can both in a couple of days, alleviate.
The present invention treats the medicine of cancer, through first Affiliated Hospital of Colleges Of Traditional Chinese Medicine Of Guangxi, second Affiliated Hospital of Colleges Of Traditional Chinese Medicine Of Guangxi, No.1 Hospital Attached to Guangxi Medical Univ., The People's Hospital, Guangxi Zhuang Autonomous Region's nearly 500 routine patient system's clinical observations, and select medical history, the state of an illness, age, sex and the suitable patient of original therapy method to compare experiment for matched group, experiment: conclusion is as follows:
1, short term effect CR, PR, NR are respectively 35%, 21.7%, 35%.Total effective rate reaches 91.7%; Matched group short term effect CR, PR, NR are respectively 25.8%, 21.7%, 34.2%, and total effective rate is 81.7%.Treatment group curative effect is higher than matched group, and difference has significance.Clinical proof medicine of the present invention has certain potentiation in nasopharyngeal carcinoma, hepatocarcinoma radiotherapy and chemotherapy.
2, the different sick efficacy results of planting show that to nasopharyngeal carcinoma and hepatocarcinoma, treatment group curative effect all is higher than according to group, and wherein to the hepatocarcinoma curative effect, the treatment group is apparently higher than matched group, and difference has significance.
3, the Karnofsky appraisal result shows, health status all has clear improvement behind two sick kind treatment groups and the matched group patient treatment, and two groups relatively, and treatment group karmofsky scoring increase all is higher than matched group, and difference has significance.Clinical proof medicine of the present invention can improve patient's quality of life in nasopharyngeal carcinoma hepatocarcinoma radiotherapy and chemotherapy.
4, treatment back clinical symptoms, sign result show, each is organized, and patient posterior nasopharynx cancer is suffered from cranial nerve nasopharynx part symptom and sign, liver cancer patient gastrointestinal symptom sign all has clear improvement.Nasopharyngeal carcinoma treatment group and matched group compare, and patient's doing well,improving is better than matched group, the significance of difference slightly.Liver cancer treatment group and matched group compare, and the improvement of patient's stomachache, nausea and vomiting symptom is significantly better than matched group, and difference has significance.Clinical proof medicine of the present invention has the effect of blood circulation promoting and blood stasis dispelling, removing toxic substances and promoting subsidence of swelling, benefiting QI and nourishing blood, cooperates radiotherapy and chemotherapy to help to improve the clinical symptoms of pharynx nasopharyngeal carcinoma, hepatocarcinoma.
5, the lab testing result shows, 1gm, OKT after treatment group, the open treatment group patient 3, OKT 4, OKT 8Be improved, wherein nasopharyngeal carcinoma patient 1gG, IgA, OKT 3Increase significance is arranged.1gG, IgA, IgM, OKT behind the matched group nasopharyngeal carcinoma regulating liver-QI carninomatosis human therapy 3, OKT 4, OKT 8Change all not quite, wherein nasopharyngeal carcinoma patient 1gA descends and liver cancer patient 1gG decline has the significance meaning.Clinical proof medicine of the present invention can improve the immunologic function of nasopharyngeal carcinoma, liver cancer patient.
6, this research has been carried out blood, just routine examination to 160 routine patients, and the heart, liver, kidney function test are not all found obvious adverse reaction and toxic and side effects.Prompting this product is clinical safe and reliable.
Case one, Deng, the man 47 years old, lives Guangxi administrative bureau of post and telecommunications.Because of right side side of body pain companion becomes thin weakly, loss of appetite 2 months was gone to a doctor on January 6th, 2000.Played no an obvious inducement before readme February and right upper quadrant of the abdomen dull pain discomfort occurs, and pursue that Zhejiang abdomen, poor appetite occur, becomes thin, symptom such as weak.Check: T37.1C, R26 time/minute, P92 time/minute, BP117/88mmHg.The chronic disease face, spirit is poor, emaciated physique, shallow complexion does not have the pool, and the skin sclera does not have xanthochromia, and the whole body superficial lymph node is little.The rhythm of the heart is neat, heart rate 92 times/minute, and pathologic murmur is not heard in each valve area.Two pulmonary respiration sounds are clear, hear and dried moist rale.Abdomen is smooth, does not see gastrointestinal type, no tenderness rebound tenderness, and liver touches under right rib, and matter is hard, and surface irregularity is nodositas, and tenderness is arranged.Do not touch under the spleen rib.Borborygmus is normal.Purplish tongue has ecchymosis, and tongue is thick in vain, hesitant pulse.Laboratory and auxiliary examination: blood, urine, stool routine examination (-).Electrocardioscopy is normal.ALT?80u,BUN?5。6mmol/L,BCr?76umol/L,AFP400ng/ml,IgG1.8g/L,IgA0.4g/L,IgM0.4g/L。Abdominal B type ultrasonography and CT examination: the about 8 * 6cm of the visible size of right lobe of liver 2[substantive space occupying lesion.Karmofsky scoring: 60 minutes.Tcm diagnosis: hypochondriac pain (syndrome of qi stagnation and blood stasis).Western medicine diagnose: primary hepatocarcinoma (II phase).Give 5-FU, PDD, MMC scheme chemotherapy, and add with clinical proof medicine of the present invention, each 6, every day 3 times.Take medicine of the present invention after 2 months, right rib pain of patient and fatigue and weakness symptom have improvement, and abdominal distention disappears, and appetite increases.Scoring: 80 minutes.Physical examination and Abdominal B type ultrasonography inspection: right lobe of liver 4 * 2.7cm 2Substantive space occupying lesion.Blood, urine, just routine examination and Electrocardioscopy no abnormality seen.AFP400ng/ml,IgG1.9g/L,IgA0.5g/L,IgM0.35g/L。ALT60u,BUN5.0mmol/L,BCr70μmol/L。Recent cancer curative effect; Partly alleviate: symptom and sign curative effect: produce effects.
Case two, Zhao, the man 45 years old, lives the metallurgical institute in Guangxi.Surplus February because of right upper quadrant of the abdomen lump pain, go to a doctor on January 24th, 2000.Right upper quadrant of the abdomen lump occurs and feels the pain discomfort before readme February, distending pain or twinge, outbreak repeatedly.With progressive emaciation, loss of appetite, nausea and vomiting, abdominal distention.Can not work normally at ordinary times, the life idol needs help, but can look after most of private demand.Chronic hepatitis B is previously arranged surplus in the of 10 year, do not have and separate tarry stools or melena history.Check: the chronic disease face, spirit is poor, emaciated physique, darkish complexion, the skin sclera does not have xanthochromia, and the whole body superficial lymph node is little.The rhythm of the heart is neat, heart rate 85 times/minute, and pathologic murmur is not heard in each valve area.Two pulmonary respiration sounds are clear, hear reaching in moist rale.Abdomen is bulge slightly, and no vena epigastrica is angry to be opened, and does not see gastrointestinal type, no tenderness rebound tenderness, and liver touches under right rib, and matter is hard, and surface irregularity is nodositas, and the limit is blunt, tenderness.Do not touch under the spleen rib.Can kowtow and shifting dullness.Borborygmus is normal.Two lower limb do not have pitting edema.Purplish tongue, white and thin fur, fat is thin.Laboratory and auxiliary examination; Routine blood test: RBC3.7 * 10 12, HB80g/L, WBC3.2 * 10 9, routine urinalysis (-), stool routine examination (-).Electrocardioscopy is normal.ALT120u,BUN5.8mmol/L,AFP400ng/ml,IgG0.2g/L,IgA0.5g/L,IgM0.4g/L。Abdominal B type ultrasonography and CT examination: the about 4 * 2cm of the visible size of right lobe of liver 2Substantive space occupying lesion.Ascites is checked: bloody ascites, and look into and see the thin breast of cancer.Karnofshy scoring: 60 minutes.Tcm diagnosis: hypochondriac pain (syndrome of qi stagnation and blood stasis).Western medicine diagnose: primary hepatocarcinoma (II phase).Give 5-FU, PDD, MMC scheme chemotherapy, and add with clinical proof medicine of the present invention, each 6, every day 3 times.After serveing on 2 months, symptoms such as the right side of body of patient pain, fatigue and weakness, abdominal distention poor appetite and nausea and vomiting are obviously improved, and spirit take a favorable turn.Karnofsky scoring: 70 minutes.Abdominal B type ultrasonography is checked: right lobe of liver 4 * 1cm 2Substantive space occupying lesion.Blood, urine, just routine examination and Electrocardioscopy no abnormality seen.AFP400ng/ml,IgG1.9/L,1gA0.55g/L,IgM0.35g/L。ALT?80,BUN5.8mmol/L,BCr90mol/L。Recent cancer curative effect: partly alleviate.Symptom and sign curative effect: produce effects.
The specific embodiment
The present invention is further illustrated below in conjunction with embodiment:
Embodiment 1
A, raw material are prepared:
(1) get rhizoma sparganic 170g, Rhizoma Curcumae 200g is ground into coarse powder, and is standby;
(2) get Herba Hedyotidis Diffusae 400g, Herba Sarcandrae 300g, Herba Scutellariae Barbatae 250g, Herba Taraxaci 200g, Radix Rehmanniae 200g, Caulis Spatholobi 200g, Radix Glycyrrhizae 50g mixing, standby;
(3) get Radix Astragali 300g, Ganoderma 100g, Fructus Lycii 100g, Radix Trichosanthis 200g mixing, standby;
(4) get Radix Sophorae Tonkinensis 200g, Radix Sophorae Flavescentis 200g, Rhizoma Corydalis 280g, Radix Salviae Miltiorrhizae 170g, Radix Ginseng 70g mixing, standby.
B, Chinese medicine preparation preparation:
(1) the coarse powder 370g of rhizoma sparganic 170g, the Rhizoma Curcumae 200g of A, (1) is added water 2200g and soak after 1 hour with vapor distillation 2 hours, divide and get volatile oil, distillate is standby, and medicinal residues are standby;
(2) the interior B of adding of medical herbs Herba Hedyotidis Diffusae 400g, Herba Sarcandrae 300gg, Herba Scutellariae Barbatae 250g, Herba Taraxaci 200g, Radix Rehmanniae 200g, Caulis Spatholobi 200g, Radix Glycyrrhizae 50g of A, (2), the medicinal residues of (1) are mixed, adding water 32kg decocted 1 hour, decocting liquid separates with medicinal residues, triplicate, collecting decoction, filter, filtrate and B, (1) distillate merge, and are concentrated into the clear paste of relative density 1.10-1.15 (60 ℃), add ethanol and make that to contain the alcohol amount be 50%, stirred evenly, leave standstill 12 hours, get supernatant liquid filtering, reclaim ethanol, concentrate, be dried to cream, it is standby to be ground into fine powder;
(3) medical herbs Radix Astragali 300g, Ganoderma 100g, Fructus Lycii 100g, the Radix Trichosanthis 200g four Chinese medicine with A, (3) adds water 10kg decoction 2 hours, and decocting liquid separates with medicinal residues, decocts repeatedly three times, waste merges three times decocting liquid, filters, filtrate concentrates, and is dried to cream, and it is standby to be ground into fine powder;
(4) medical herbs Radix Sophorae Tonkinensis 200g, Radix Sophorae Flavescentis 200g, Rhizoma Corydalis 280g, Radix Salviae Miltiorrhizae 170g, the Radix Ginseng 70g five kinds of Chinese medicine with A, (4) adds 70% ethanol 8.3kg immersion 1 hour, backflow repeats to extract three times, each 1 hour, merge extractive liquid,, filter, filtrate recycling ethanol concentrates, be dried to dried cream, it is standby to be ground into fine powder;
C, finished product processing, packing, check:
(1) capsule:
With B, (2), B, (3), the fine powder of B, (4) preparation merges, and mixes, and granulates, and spray adds B, (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, and moistening, to sterilize, incapsulate, test inspection qualified, is finished product.
(2) pill:
With B, (2), B, (3), the fine powder of B, (4) preparation merges, and mixes, makes pill, and spray adds B, (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, moistening, the close ball of sterilizing, pack into, is up to the standards, and is finished product.
(3) tablet:
With B, (2), B, (3), the fine powder of B, (4) preparation merges, and mixes, makes tablet, and spray adds B, (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, moistening, the medicine bottle of sterilizing, pack into, is up to the standards, and is finished product.
(4) powder:
With B, (2), B, (3), the fine powder of B, (4) preparation merges, and mixes, makes powder, and spray adds B, (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, moistening, the packaging bag of sterilizing, pack into, is up to the standards, and is finished product.
The invention is not restricted to above-mentioned capsule, pill, tablet, powder, also comprise oral liquid etc., said dosage form on promptly any pharmaceutics.
Embodiment 2
A, raw material are prepared:
(1) get rhizoma sparganic 280g, Rhizoma Curcumae 300g is ground into coarse powder, and is standby; (2) get Herba Hedyotidis Diffusae 800g, Herba Sarcandrae 700g, Herba Scutellariae Barbatae 600g, Herba Taraxaci 280g, Radix Rehmanniae 300g, Caulis Spatholobi 300g, Radix Glycyrrhizae 80g mixing, standby;
(3) get Radix Astragali 450g, Ganoderma 150g, Fructus Lycii 150g, Radix Trichosanthis 280g mixing, standby;
(4) get Radix Sophorae Tonkinensis 280g, Radix Sophorae Flavescentis 300g, Rhizoma Corydalis 500g, Radix Salviae Miltiorrhizae 500g, Radix Ginseng 120g mixing, standby.
B, Chinese medicine preparation preparation:
(1) the coarse powder 580g of rhizoma sparganic 280g, the Rhizoma Curcumae 300g of A, (1) is added water 2880g and soak after 1 hour with vapor distillation 2 hours, divide and get volatile oil, distillate is standby, and medicinal residues are standby;
(2) the interior B of adding of medical herbs Herba Hedyotidis Diffusae 800g, Herba Sarcandrae 700gg, Herba Scutellariae Barbatae 600g, Herba Taraxaci 280g, Radix Rehmanniae 300g, Caulis Spatholobi 300g, Radix Glycyrrhizae 80g of A, (2), the medicinal residues of (1) are mixed, adding water 32kg decocted 1 hour, decocting liquid separates with medicinal residues, triplicate, collecting decoction, filter, filtrate and B, (1) distillate merge, and are concentrated into the clear paste of relative density 1.10-1.15 (60 ℃), add ethanol and make that to contain the alcohol amount be 50%, stirred evenly, leave standstill 12 hours, get supernatant liquid filtering, reclaim ethanol, concentrate, be dried to cream, it is standby to be ground into fine powder;
(3) medical herbs Radix Astragali 450g, Ganoderma 150g, Fructus Lycii 150g, the Radix Trichosanthis 280g four Chinese medicine with A, (3) adds water 10kg decoction 2 hours, and decocting liquid separates with medicinal residues, decocts repeatedly three times, waste merges three times decocting liquid, filters, filtrate concentrates, and is dried to cream, and it is standby to be ground into fine powder;
(4) medical herbs Radix Sophorae Tonkinensis 280g, Radix Sophorae Flavescentis 300g, Rhizoma Corydalis 50g, Radix Salviae Miltiorrhizae 500g, the Radix Ginseng 120g five kinds of Chinese medicine with A, (4) adds 70% ethanol 8.3kg immersion 1 hour, backflow repeats to extract three times, each 1 hour, merge extractive liquid,, filter, filtrate recycling ethanol concentrates, be dried to dried cream, it is standby to be ground into fine powder;
C, finished product processing, packing, check:
(1) capsule:
With B, (2), B, (3), the fine powder of B, (4) preparation merges, and mixes, and granulates, and spray adds B, (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, and moistening, to sterilize, incapsulate, test inspection qualified, is finished product.
(2) pill:
With B, (2), B, (3), the fine powder of B, (4) preparation merges, and mixes, makes pill, and spray adds B, (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, moistening, the close ball of sterilizing, pack into, is up to the standards, and is finished product.
(3) tablet:
With B, (2), B, (3), the fine powder of B, (4) preparation merges, and mixes, makes tablet, and spray adds B, (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, moistening, the medicine bottle of sterilizing, pack into, is up to the standards, and is finished product.
(4) powder:
With B, (2), B, (3), the fine powder of B, (4) preparation merges, and mixes, makes powder, and spray adds B, (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, moistening, the packaging bag of sterilizing, pack into, is up to the standards, and is finished product.
The invention is not restricted to above-mentioned capsule, pill, tablet, powder, also comprise oral liquid etc., said dosage form on promptly any pharmaceutics.
Embodiment 3
A, raw material are prepared:
(1) get rhizoma sparganic 240g, Rhizoma Curcumae 240g is ground into coarse powder, and is standby;
(2) get Herba Hedyotidis Diffusae 720g, Herba Sarcandrae 600g, Herba Scutellariae Barbatae 480g, Herba Taraxaci 240g, Radix Rehmanniae 240g, Caulis Spatholobi 240g, Radix Glycyrrhizae 60g mixing, standby;
(3) get Radix Astragali 360g, Ganoderma 120g, Fructus Lycii 120g, Radix Trichosanthis 240g mixing, standby;
(4) get Radix Sophorae Tonkinensis 240g, Radix Sophorae Flavescentis 240g, Rhizoma Corydalis 360g, Radix Salviae Miltiorrhizae 240g, Radix Ginseng 96g mixing, standby.
B, Chinese medicine preparation preparation:
(1) the coarse powder 480g of rhizoma sparganic 240g, the Rhizoma Curcumae 240g of A, (1) is added water 2880g and soak after 1 hour with vapor distillation 2 hours, divide and get volatile oil, distillate is standby, and medicinal residues are standby;
(2) the interior B of adding of medical herbs Herba Hedyotidis Diffusae 720g, Herba Sarcandrae 600g, Herba Scutellariae Barbatae 480g, Herba Taraxaci 240g, Radix Rehmanniae 240g, Caulis Spatholobi 240g, Radix Glycyrrhizae 60g of A, (2), the medicinal residues of (1) are mixed, adding water 32kg decocted 1 hour, decocting liquid separates with medicinal residues, triplicate, collecting decoction, filter, filtrate and B, (1) distillate merge, and are concentrated into the clear paste of relative density 1.10-1.15 (60 ℃), add ethanol and make that to contain the alcohol amount be 50%, stirred evenly, leave standstill 12 hours, get supernatant liquid filtering, reclaim ethanol, concentrate, be dried to cream, it is standby to be ground into fine powder;
(3) medical herbs Radix Astragali 360g, Ganoderma 120g, Fructus Lycii 120g, the Radix Trichosanthis 240g four Chinese medicine with A, (3) adds water 10kg decoction 2 hours, and decocting liquid separates with medicinal residues, decocts repeatedly three times, waste merges three times decocting liquid, filters, filtrate concentrates, and is dried to cream, and it is standby to be ground into fine powder;
(4) medical herbs Radix Sophorae Tonkinensis 240g, Radix Sophorae Flavescentis 240g, Rhizoma Corydalis 360, Radix Salviae Miltiorrhizae 240g, the Radix Ginseng 96g five kinds of Chinese medicine with A, (4) adds 70% ethanol 8.3kg immersion 1 hour, backflow repeats to extract three times, each 1 hour, merge extractive liquid,, filter, filtrate recycling ethanol concentrates, be dried to dried cream, it is standby to be ground into fine powder;
C, finished product processing, packing, check:
(1) capsule:
With B, (2), B, (3), the fine powder of B, (4) preparation merges, and mixes, and granulates, and spray adds B, (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, and moistening, to sterilize, incapsulate, test inspection qualified, is finished product.
(2) pill:
With B, (2), B, (3), the fine powder of B, (4) preparation merges, and mixes, makes pill, and spray adds B, (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, moistening, the close ball of sterilizing, pack into, is up to the standards, and is finished product.
(3) tablet:
With B, (2), B, (3), the fine powder of B, (4) preparation merges, and mixes, makes tablet, and spray adds B, (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, moistening, the medicine bottle of sterilizing, pack into, is up to the standards, and is finished product.
(4) powder:
With B, (2), B, (3), the fine powder of B, (4) preparation merges, and mixes, makes powder, and spray adds B, (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, moistening, the packaging bag of sterilizing, pack into, is up to the standards, and is finished product.
The invention is not restricted to above-mentioned capsule, pill, tablet, powder, also comprise oral liquid etc., said dosage form on promptly any pharmaceutics.

Claims (3)

1, a kind of Chinese medicine preparation for the treatment of malignant tumor is characterized in that: this Chinese medicine preparation is to be made by the raw material of following weight parts: Herba Hedyotidis Diffusae 400-800, Herba Sarcandrae 300-700, Herba Scutellariae Barbatae 250-600, Rhizoma Corydalis 280-500, rhizoma sparganic 170-280, Rhizoma Curcumae 200-300, Radix Salviae Miltiorrhizae 170-500, Radix Ginseng 70-120, Radix Astragali 300-450, Ganoderma 100-150, Caulis Spatholobi 200-300, Radix Rehmanniae 200-300, Fructus Lycii 100-150, Radix Trichosanthis 200-280, Herba Taraxaci 200-280, Radix Sophorae Tonkinensis 200-280, Radix Sophorae Flavescentis 200-300, Radix Glycyrrhizae 50-80.
2, the Chinese medicine preparation of treatment malignant tumor according to claim 1 is characterized in that: this Chinese medicine preparation is to be made by the raw material of following weight parts: Herba Hedyotidis Diffusae 720, Herba Sarcandrae 600, Herba Scutellariae Barbatae 480, Rhizoma Corydalis 360, rhizoma sparganic 240, Rhizoma Curcumae 240, Radix Salviae Miltiorrhizae 240, Radix Ginseng 96, the Radix Astragali 360, Ganoderma 120, Caulis Spatholobi 240, the Radix Rehmanniae 240, Fructus Lycii 120, Radix Trichosanthis 240, Herba Taraxaci 240, Radix Sophorae Tonkinensis 240, Radix Sophorae Flavescentis 240, Radix Glycyrrhizae 60.
3, a kind of preparation method for the treatment of the Chinese medicine preparation of malignant tumor, it is characterized in that: this method may further comprise the steps:
A, raw material are prepared:
(1) get rhizoma sparganic 240g, Rhizoma Curcumae 240g is ground into coarse powder, and is standby;
(2) get Herba Hedyotidis Diffusae 720g, Herba Sarcandrae 600g, Herba Scutellariae Barbatae 480g, Herba Taraxaci 240g, Radix Rehmanniae 240g, Caulis Spatholobi 240g, Radix Glycyrrhizae 60g mixing, standby;
(3) get Radix Astragali 360g, Ganoderma 120g, Fructus Lycii 120g, Radix Trichosanthis 240g mixing, standby;
(4) get Radix Sophorae Tonkinensis 240g, Radix Sophorae Flavescentis 240g, Rhizoma Corydalis 360g, Radix Salviae Miltiorrhizae 240g, Radix Ginseng 96g mixing, standby;
B, Chinese medicine preparation preparation:
(1) coarse powder of rhizoma sparganic 240g, the Rhizoma Curcumae 240g of steps A (1) is amounted to 480g and add water 2880g and soak after 1 hour with vapor distillation 2 hours, divide and get volatile oil, distillate is standby, and medicinal residues are standby;
(2) with the interior medicinal residues mixing that adds step B (1) of medical herbs Herba Hedyotidis Diffusae 720g, Herba Sarcandrae 600g, Herba Scutellariae Barbatae 480g, Herba Taraxaci 240g, Radix Rehmanniae 240g, Caulis Spatholobi 240g, the Radix Glycyrrhizae 60g of steps A (2), adding water 32kg decocted 1 hour, decocting liquid separates with medicinal residues, triplicate, collecting decoction, filter, filtrate and step B (1) distillate merge, the clear paste that 60 ℃ of temperature are concentrated into relative density 1.10 adds ethanol makes that to contain the alcohol amount be 50%, stirs evenly, leaves standstill 12 hours, gets supernatant liquid filtering, reclaim ethanol, concentrate, be dried to cream, it is standby to be ground into fine powder;
(3) medical herbs Radix Astragali 360g, Ganoderma 120g, Fructus Lycii 120g, the Radix Trichosanthis 240g four Chinese medicine with steps A (3) adds water 10kg decoction 2 hours, and decocting liquid separates with medicinal residues, decocts repeatedly three times, waste merges three times decocting liquid, filters, filtrate concentrates, and is dried to cream, and it is standby to be ground into fine powder;
(4) medical herbs Radix Sophorae Tonkinensis 240g, Radix Sophorae Flavescentis 240g, Rhizoma Corydalis 360g, Radix Salviae Miltiorrhizae 240g, the Radix Ginseng 96g five kinds of Chinese medicine with steps A (4) adds 70% ethanol 8.3kg immersion 1 hour, backflow repeats to extract three times, each 1 hour, merge extractive liquid,, filter, filtrate recycling ethanol concentrates, be dried to dried cream, it is standby to be ground into fine powder;
C, finished product processing, packing, check:
(1) capsule:
The fine powder of step B (2), step B (3), step B (4) preparation is merged, mix, granulate, spray adds step B (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, and moistening, to sterilize, incapsulate, test inspection qualified, is finished product;
(2) pill:
The fine powder of step B (2), step B (3), step B (4) preparation is merged, mix, make pill, spray adds step B (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, moistening, the close ball of sterilizing, pack into, is up to the standards, and is finished product;
(3) tablet:
The fine powder of step B (2), step B (3), step B (4) preparation is merged, mix, make tablet, spray adds step B (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, moistening, the medicine bottle of sterilizing, pack into, is up to the standards, and is finished product;
(4) powder:
The fine powder of step B (2), step B (3), step B (4) preparation is merged, mix, make powder, spray adds step B (1) rhizoma sparganic, Rhizoma Curcumae volatile oil, moistening, the packaging bag of sterilizing, pack into, is up to the standards, and is finished product.
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CN1325106C (en) * 2004-06-24 2007-07-11 贵州渝生制药有限公司 Chinese medicinal preparation for treating malignant tumor and production thereof
CN100455322C (en) * 2006-05-17 2009-01-28 郭富红 A Chinese medicine for treating cancer
CN101011559B (en) * 2007-02-01 2011-06-01 南中兴 Traditional Chinese medicine preparation for treating malignant tumor and its preparation method
CN101209334B (en) * 2007-12-25 2010-07-28 孙绍彬 Lung cancer-treating medicament and preparation thereof
CN102366464B (en) * 2011-11-14 2014-02-12 范圣刚 Antitumor traditional Chinese medicine composition
CN103479933B (en) * 2013-06-28 2015-09-23 天津弘昇药物研究有限公司 Chinese medicine composition of a kind of Therapeutic cancer and preparation method thereof
CN104324110A (en) * 2014-11-10 2015-02-04 文怡海 Medicine for treating intestinal and uterine malignant tumors and preparation method
CN104998050A (en) * 2015-07-04 2015-10-28 青岛辰达生物科技有限公司 Traditional Chinese medicine preparation used for treating malignant tumor combined immune deficit
CN106620517A (en) * 2016-09-21 2017-05-10 深圳市得道中医馆管理有限责任公司 Traditional Chinese medicine composition, and preparation method and application thereof in treatment of nasopharyngeal carcinoma
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* Cited by examiner, † Cited by third party
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