CN104147321A

CN104147321A - Traditional Chinese medicine preparation for treating exuberant fire and heat type radioactive salivary gland damage

Info

Publication number: CN104147321A
Application number: CN201410412932.7A
Authority: CN
Inventors: 杨涛
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-08-16
Filing date: 2014-08-16
Publication date: 2014-11-19

Abstract

The invention discloses a traditional Chinese medicine preparation for treating exuberant fire and heat type radioactive salivary gland damage. In the traditional Chinese medicine theory, rays are taken as an external evil, can cause diseases having the characteristics of diseases caused by fire heat and diseases caused by toxic evil, can invade a person from the exterior surface and then penetrate to the internal organs, can directly damage the internal organs, and are a strong pathogenic factor. The preparation is made of the following traditional Chinese herbals having the functions of clearing heat, removing toxicity, nourishing yin, engendering liquid, cooling blood, and activating blood: chondrilla juncea, hairy holly leaf, oxalis corymbosa, winter sweet root, hippuris vulgaris, Japanese snake gourd root, longspurred fairybells rhizome, phymatopsis griffithiana, coelomactra antiquata, diospyros lotus, yellow fungus, and stenosolenium saxatile root. The decoction is prepared by decocting the raw materials mentioned above in water. The total effective rate of the preparation is 94.3%, and the curative effect is prominent. During the whole treatment course, no obvious adverse reaction happens, and no obvious change is observed in blood, urine, and stool routine examinations, electrocardiogram, liver function, and kidney function.

Description

A kind of Chinese medicine preparation for the treatment of burning hot flourishing type radioactivity salivary gland damage

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine preparation for the treatment of burning hot flourishing type radioactivity salivary gland damage.

Background technology

China's tumor of head and neck sickness rate is higher, and radiotherapy is the first-selection for the treatment of tumor of head and neck.Because of salivary gland and nasopharynx, oropharynx, thyroid close together, at protection spinal cord simultaneously for guaranteeing the amount of being subject to of tumor, salivary gland inevitably irradiated and dosage higher, therefore radioactivity salivary gland damage sickness rate is higher.At present in the control that radiation is caused to salivary gland damage mainly by the following method: 1. by gland transposition under neck, or change traditional radiation modality into damage that three dimensional conformal radiation therapy, Intensity Modulation Radiated Therapy (IMRT) etc. reduce salivary gland, alleviate radioactivity salivary gland damage symptom; 2. use salivary gland cell protective agent, as amifostine, the protection such as adrenoceptor agonists salivary gland cell, alleviates the damage of radioactivity salivary gland; 3. application promotes the medicine of salivation, as M cholinergic receptor agonist, alleviates the symptom of radioactivity salivary gland damage; 4. application aquaporin increases the secretory volume of saliva.Yet said method clinically curative effect is not good enough, and the side effect that medicine brings also brings burden to patient.Applicant, according to the pathogenic characteristic of ray, etiology and pathogenesis etc., utilizes this disease of Chinese medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, has obtained good effect, and safe and reliable, and treatment cost is low.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of burning hot flourishing type radioactivity salivary gland damage.Ray is as a kind of external heresy, and existing " intimately " pathogenic feature, has again " poison is evil " pathogenic characteristic concurrently.Both can invade the change of disease to internal organs from body surface, and can directly injure internal organs again, be strong paathogenic factor.The suitable heat-clearing and toxic substances removing of Chinese traditional treatment, YIN nourishing and the production of body fluid promoting, removing heat from blood and promoting blood circulation.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of the burning hot flourishing type radioactivity salivary gland damage of this treatment is made by the Chinese medicine of following weight portion: herba ineritis gracilis 5-10 part, Folium Ilicis Pubescentis 3-9 part, Herba oxalidis corymbosae 10-20 part, Radix Chimonanthi praecocis 3-6 part, Herba Hippuridis Vulgaris 4-10 part, Radix Trichosanthis Cucumeroidis 2-5 part, Rhizoma Dispori Calcarati 8-10 part, Phymatopsis griffithiana (Hook.) J. Sm. 4-8 part, Mactraantiquata Spengler 10-20 part, Fructus Dispyroris Loti 6-10 part, Tremella mesenterica Retz ex Fr. 5-10 part, Radix Stenosolenii saxatilis 3-6 part.

Preferably, 7 parts of herba ineritis graciliss, 6 parts of Folium Ilicis Pubescentiss, 15 parts of Herba oxalidis corymbosaes, 5 parts of Radix Chimonanthi praecocis, 7 parts of Herba Hippuridis Vulgaris, 3 parts of Radix Trichosanthis Cucumeroidiss, 9 parts of Rhizoma Dispori Calcaratis, 6 parts of Phymatopsis griffithiana (Hook.) J. Sm.s, 15 parts of Mactraantiquata Spenglers, 8 parts of Fructus Dispyroris Loti, 7 parts of Tremella mesenterica Retz ex Fr.s, 4 parts of Radix Stenosolenii saxatiliies.

Preparation method decocting is made decoction.

In side: herba ineritis gracilis, Folium Ilicis Pubescentis heat-clearing and toxic substances removing, analgesic antiphlogistic; Herba oxalidis corymbosae heat-clearing and toxic substances removing, eliminating stasis to stop pain; Radix Chimonanthi praecocis heat-clearing and toxic substances removing, stasis-dispelling and pain-killing, promoting blood circulation and detumescence; Herba Hippuridis Vulgaris clearing away heat and cooling blood, the nutrient solution of promoting the production of body fluid; Radix Trichosanthis Cucumeroidis purges heat, promotes the production of body fluid, removing blood stasis, repercussive; Rhizoma Dispori Calcarati promoting the production of body fluid and benefiting QI, nourishing YIN and moistening the lung; Phymatopsis griffithiana (Hook.) J. Sm. clearing away heat and cooling blood, removing toxic substances; Mactraantiquata Spengler YIN nourishing nutrient solution, the cool liver of heat clearing away; Fructus Dispyroris Loti quenches the thirst, heat clearing away and restlessness relieving; Tremella mesenterica Retz ex Fr. nourishing YIN and moistening the lung, promote the production of body fluid; Radix Stenosolenii saxatilis clearing away heat and cooling blood, hemostasis cough-relieving.

Clinical data

1, this group of physical data is Nasopharyngeal Carcinoma Patients, totally 35 examples.Man's 24 examples, female's 11 examples; 30～74 years old age, average 48 years old.All patients all make a definite diagnosis through CT, x-ray, pathological biopsy, scale cancer 31 examples wherein, adenocarcinoma 3 examples, undifferentiated carcinoma 1 example.

2, this research of diagnostic criteria is according to the grade scale RTOG grade scale of international radioactivity salivary gland damage, the < < clinical disease diagnosis of editing with reference to Sun Chuanxing is according to curing improvement standard > > (Beijing: People's Medical Officer Press, 1998.6) the 7th piece of diagnostic criteria that chapter 4 radiation sickness is formulated in, and diagnose in conjunction with patient's symptom, sign and radiation history.Diagnostic criteria is as follows: the tumor of head and neck patients such as the nasopharyngeal carcinoma that make a definite diagnosis through pathologic finding (1), hypopharyngeal cancer, carcinoma of tongue, in head-cervical radiotherapy process or previously have a head-cervical radiotherapy history person; (2) clinical manifestation is xerostomia in various degree, or can be with because of pain, and the oral cavity film that slits is dry, enters xerophagia difficulty, difficulty speaking, dry nasal cavity, Huo Lingxiaxian district, parotid region swelling pain etc.

Burning hot flourishing type radial pattern salivary gland damages dialectical disease: 1. xerostomia; 2. pharyngitis causalgia, neck descend distending pain; 3. dry lip, has no shame and splits; 4. like the water of drinking ice, pain is swallowed in feed; 5. irritated, irritability; 6. large dry stool, yellow urine; 7. red tongue with yellow fur is dry; 8. rapid pulse.Below 1., 7., 8. must possess, and should have all the other in every 2 concurrently.

3, treatment and care method patient use Chinese medicine preparation of the present invention, take herba ineritis gracilis 7g, Folium Ilicis Pubescentis 6g, Herba oxalidis corymbosae 15g, Radix Chimonanthi praecocis 5g, Herba Hippuridis Vulgaris 7g, Radix Trichosanthis Cucumeroidis 3g, Rhizoma Dispori Calcarati 9g, Phymatopsis griffithiana (Hook.) J. Sm. 6g, Mactraantiquata Spengler 15g, Fructus Dispyroris Loti 8g, Tremella mesenterica Retz ex Fr. 7g, Radix Stenosolenii saxatilis 4g, decocting is made decoction, oral 50ml/ time, 3 times/d, with radiotherapy within the 1st day, rise to last 1 day of radiotherapy only, adhere to every day taking.

4, criterion of therapeutical effect (1) clinical recovery: xerostomia transference cure, the feed of speaking does not hinder, without frequent drinking-water; (2) be clearly better: xerostomia symptom obviously alleviates, drinking-water is gargled profit number of times and is reduced more than 2/3; (3) take a turn for the better: xerostomia alleviates, drinking-water is gargled profit number of times and is reduced more than 1/3; (4) invalid: xerostomia alleviates not obvious, drinking-water is gargled profit number of times and is reduced less than 1/3.

5, the routine patient of therapeutic outcome 35 clinical recovery 11 examples (31.4%) wherein, 12 examples that are clearly better (34.3%), 10 examples (28.6%) that take a turn for the better, invalid 2 examples (5.7%), total effective rate 94.3%, evident in efficacy.In whole therapeutic process, there is not obvious untoward reaction in patient, and blood, urine, stool routine examination, electrocardiogram and liver, renal function have no significant change.

The specific embodiment

Embodiment mono-: take herba ineritis gracilis 7g, Folium Ilicis Pubescentis 6g, Herba oxalidis corymbosae 15g, Radix Chimonanthi praecocis 5g, Herba Hippuridis Vulgaris 7g, Radix Trichosanthis Cucumeroidis 3g, Rhizoma Dispori Calcarati 9g, Phymatopsis griffithiana (Hook.) J. Sm. 6g, Mactraantiquata Spengler 15g, Fructus Dispyroris Loti 8g, Tremella mesenterica Retz ex Fr. 7g, Radix Stenosolenii saxatilis 4g, decocting is made decoction.

Embodiment bis-: take herba ineritis gracilis 10g, Folium Ilicis Pubescentis 3g, Herba oxalidis corymbosae 20g, Radix Chimonanthi praecocis 3g, Herba Hippuridis Vulgaris 10g, Radix Trichosanthis Cucumeroidis 2g, Rhizoma Dispori Calcarati 10g, Phymatopsis griffithiana (Hook.) J. Sm. 4g, Mactraantiquata Spengler 20g, Fructus Dispyroris Loti 6g, Tremella mesenterica Retz ex Fr. 10g, Radix Stenosolenii saxatilis 3g, decocting is made decoction.

Embodiment tri-: take herba ineritis gracilis 5g, Folium Ilicis Pubescentis 9g, Herba oxalidis corymbosae 10g, Radix Chimonanthi praecocis 6g, Herba Hippuridis Vulgaris 4g, Radix Trichosanthis Cucumeroidis 5g, Rhizoma Dispori Calcarati 8g, Phymatopsis griffithiana (Hook.) J. Sm. 8g, Mactraantiquata Spengler 10g, Fructus Dispyroris Loti 10g, Tremella mesenterica Retz ex Fr. 5g, Radix Stenosolenii saxatilis 6g, decocting is made decoction.

Claims

1. treat a Chinese medicine preparation for burning hot flourishing type radioactivity salivary gland damage, it is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: herba ineritis gracilis 5-10 part, Folium Ilicis Pubescentis 3-9 part, Herba oxalidis corymbosae 10-20 part, Radix Chimonanthi praecocis 3-6 part, Herba Hippuridis Vulgaris 4-10 part, Radix Trichosanthis Cucumeroidis 2-5 part, Rhizoma Dispori Calcarati 8-10 part, Phymatopsis griffithiana (Hook.) J. Sm. 4-8 part, Mactraantiquata Spengler 10-20 part, Fructus Dispyroris Loti 6-10 part, Tremella mesenterica Retz ex Fr. 5-10 part, Radix Stenosolenii saxatilis 3-6 part.

2. a kind of Chinese medicine preparation for the treatment of burning hot flourishing type radioactivity salivary gland damage according to claim 1, is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: 7 parts of herba ineritis graciliss, 6 parts of Folium Ilicis Pubescentiss, 15 parts of Herba oxalidis corymbosaes, 5 parts of Radix Chimonanthi praecocis, 7 parts of Herba Hippuridis Vulgaris, 3 parts of Radix Trichosanthis Cucumeroidiss, 9 parts of Rhizoma Dispori Calcaratis, 6 parts of Phymatopsis griffithiana (Hook.) J. Sm.s, 15 parts of Mactraantiquata Spenglers, 8 parts of Fructus Dispyroris Loti, 7 parts of Tremella mesenterica Retz ex Fr.s, 4 parts of Radix Stenosolenii saxatiliies.