CN104606500A

CN104606500A - Traditional Chinese medicine preparation for treating fire excess from Yin deficiency type radioactive salivary gland toxicity

Info

Publication number: CN104606500A
Application number: CN201510031438.0A
Authority: CN
Inventors: 范广法; 王雪晴
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-01-17
Filing date: 2015-01-17
Publication date: 2015-05-13

Abstract

The invention discloses a traditional Chinese medicine preparation for treating fire excess from Yin deficiency type radioactive salivary gland toxicity. The fire excess from Yin deficiency type radioactive salivary gland toxicity is mainly caused by that pathogenic fire-heat tends to consume the body fluid and leads to deficiency of body fluid, and the deficiency of Yin and Qi supports. The traditional Chinese medicine preparation is that Chinese herbal medicines capable of clearing away heat and toxic materials and nourishing Yin for moistening dryness, including impatiens balsamina, heteropanax fragrans, Chinese buckthorn root bark, salvia cavaleriel, pogostemon glaber, eria graminifolia, coelogyne occultata, rhizome of perny false fairybells rhizome, noxious ranunculus fruit, intermediate peashrub flower, delavay parnassia herb and lethariella cladonioides are decocted with water to obtain decoction. The clinical experiment shows that the traditional Chinese medicine preparation has the advantage that the effect of reducing various pathogenic symptoms is obviously superior to that of a contrast; the traditional Chinese medicine preparation is worthy of clinical popularization and application.

Description

A kind of Chinese medicine preparation for the treatment of the damage of type of hyperactivity of fire caused by deficiency of YIN radioactivity salivary gland

Technical field

The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine preparation for the treatment of the damage of type of hyperactivity of fire caused by deficiency of YIN radioactivity salivary gland.

Background technology

Radiotherapy is the important component part of clinical tumor Comprehensive Treatment.High-energy ray, while killing tumor cell, also damages normal structure, organ and the medulla hematopoietic system in irradiation area, produces toxic and side effects in various degree.The radioactivity salivary gland Damage Acute phase is mainly salivary gland inflammation, the vigorous film inflammation in oral cavity etc., and clinical manifestation is xerostomia, parotid region congestion and swelling pain, oral ulcer etc.; Chronic radioactive salivary gland damages the lighter only has xerostomia, drinks water or takes a turn for the better after feed, and the complication such as difficulty, impact sleep, gustatory anesthesia, dental caries generation and buccal cavity fungal infection can be swallowed and talk to severe patient, has a strong impact on the life quality of patient.Doctor trained in Western medicine still lacks effective method preventing and treating in the damage of radioactivity salivary gland, and as gland transposition under neck, the blood supply of postoperative local changes, to the long-term efficacy of the symptom of patient's saliva damage and do not have clinical evidence to metastases in local lymph node situation; Existing chemicals and the biological preparation preventing and treating the damage of radioactivity salivary gland, often with more serious untoward reaction, and offer limited effectiveness.In recent years, applicant adopts treatment by Chinese herbs, and this was sick, achieve good curative effect, and side effect was little.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of the damage of type of hyperactivity of fire caused by deficiency of YIN radioactivity salivary gland.Type of hyperactivity of fire caused by deficiency of YIN radioactivity salivary gland damages its morbidity based on burning hot evil impairment of body fluid consumption liquid, and the deficiency of YIN, the deficiency of vital energy are auxiliary.Be heat-clearing and toxic substances removing, nourshing Yin and drynsessmoistening prescription according to its Therapeutic Principle of pathogenic characteristic.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment type of hyperactivity of fire caused by deficiency of YIN radioactivity salivary gland damage is made up of the Chinese medicine of following weight portion: Flos Impatientis 20-30 part, Radix seu Cortex Heteropanacis Fragrantis 5-15 part, Radix seu cortex rhamni utilis 10-20 part, Herba Salviae Simplicifoliae 10-20 part, thorn stamen grass 20-30 part, Herba Eriae Graminifoliae 5-10 part, Herba Coelogynes 4-8 part, Rhizoma disporopsis pernyi 6-10 part, Fructus Ranunculi Scelerati 3-5 part, Flos Caraganae intermediae 4-10 part, Herba Parnassiae Delavayi 6-10 part, Thamnolia vermicularis (Ach.) Asa-hina 5-10 part.

Preferably, Flos Impatientis 25 parts, Radix seu Cortex Heteropanacis Fragrantis 10 parts, Radix seu cortex rhamni utilis 15 parts, Herba Salviae Simplicifoliae 15 parts, thorn stamen grass 25 parts, Herba Eriae Graminifoliae 7 parts, Herba Coelogynes 6 parts, Rhizoma disporopsis pernyi 8 parts, Fructus Ranunculi Scelerati 4 parts, Flos Caraganae intermediae 6 parts, Herba Parnassiae Delavayi 8 parts, Thamnolia vermicularis (Ach.) Asa-hina 7 parts.

Preparation method decocting makes decoction.

Fang Zhong: Flos Impatientis blood circulation and channel invigorating, heat-clearing and toxic substances removing; Radix seu Cortex Heteropanacis Fragrantis removing heat from blood, detoxify, invigorate blood circulation, reducing swelling and alleviating pain; Radix seu cortex rhamni utilis clearing away heat and cooling blood, removing toxic substances; Herba Salviae Simplicifoliae cooling blood for hemostasis, clearing away damp-heat; The cooling blood for hemostasis of thorn stamen grass, heat-clearing and toxic substances removing; Herba Eriae Graminifoliae nourishing yin for benefiting stomach, born fluid; Herba Coelogynes tonifying-Yin and nourishing-stomach, promoting the production of body fluid to quench thirst, relieving restlessness; Rhizoma disporopsis pernyi nourishing YIN and moistening the lung, promoting the production of body fluid to quench thirst; Fructus Ranunculi Scelerati YIN nourishing supports essence, cough-relieving relieving restlessness, wind-damp dispelling; Flos Caraganae intermediae nourishing the blood and yin; Herba Parnassiae Delavayi clearing heat and moistening lung, reducing swelling and alleviating pain; Thamnolia vermicularis (Ach.) Asa-hina heat clearing away is quenched one's thirst, refreshment and tranquilization.

Clinical data

1, selected by physical data, Gender is not limit, 19 ~ 71 years old age; Patient is controlled at the beginning of the nasopharyngeal carcinoma that histopathology confirms; Ka Shi marks > 70 points; Estimate life cycle and be not less than 6 months; Without serious systemic disease and chronic salivary gland medical history; Irradiation field comprises the main salivary gland of bilateral, and radiological dose DT > 60Gy; Voluntary received treatment of Chinese herbs also signs Informed Consent Form.Accept Nasopharyngeal Carcinoma Patients 60 example meeting above standard.Selected patient adopts open randomized blocks to be divided into Chinese medicine plus radiotherapy group (treatment group) 30 example and radiation alone group (matched group) 30 example.Two groups of Genders, age and incidences are through statistical procedures, and difference no statistical significance (P > 0.05), has comparability.

2, diagnostic criteria type of hyperactivity of fire caused by deficiency of YIN radial pattern salivary gland damages dialectical disease: 1. xerostomia is for drink; 2. dryness and uneasy feeling of the eye's pain; 3. dysphoria with feverish sensation in the chest palms and soles, afternoon or heating at night; 4. flushed cheeks; 5. hectic fever night sweat or polyhidrosis of the palms and soles go out; 6. red tongue with a little fluid, yellow fur or tongue peel off; 7. thready and rapid pulse.6., 7. above-mentioned must possess, should have concurrently all the other every in 1.

3, Therapeutic Method treatment group patient uses Chinese medicine preparation of the present invention, take Flos Impatientis 25g, Radix seu Cortex Heteropanacis Fragrantis 10g, Radix seu cortex rhamni utilis 15g, Herba Salviae Simplicifoliae 15g, thorn stamen grass 25g, Herba Eriae Graminifoliae 7g, Herba Coelogynes 6g, Rhizoma disporopsis pernyi 8g, Fructus Ranunculi Scelerati 4g, Flos Caraganae intermediae 6g, Herba Parnassiae Delavayi 8g, Thamnolia vermicularis (Ach.) Asa-hina 7g, after decocting points 2 times oral, after radiotherapy starts to terminate to whole process for the 1st day 4 weeks.

4, observation index judges xerostomia degree, and the first visit first day, treatments period to radiotherapy terminate 4 weeks, 1 time weekly.Salivary gland function respectively at before radiotherapy, radiotherapy terminates and radiotherapy terminates 4 weeks, by clinical assays saliva flow rate, observes the uptake ratio (UR) of bilateral parotid and acid reaction excretion rate (ER).Treatment before and after look Liver and kidney function.

5, therapeutic outcome

After the radiotherapy of (1) two group of clinical symptoms comparison therapy group Different periods xerostomia degree all comparatively matched group alleviate, difference has statistical significance (P < 0.05).In table 1.

Different periods xerostomia classification situation after table 1 liang group radiotherapy

(2) the static flow rate measurements display of salivary gland flow rate variation situation two groups of patient's salivary gland, when treatment group and matched group radiotherapy terminate 0 week and 4 weeks, all comparatively radiotherapy is front obviously declines, and difference has statistical significance (P < 0.05); Treatment group and matched group radiotherapy terminate the no significant difference (P > 0.05) between 0 week and 4 weeks static flow rates.Two groups of dynamic flow rate measurements displays of patient's salivary gland, when treatment group and matched group radiotherapy terminate 0 week and 4 weeks, all comparatively radiotherapy is front obviously declines, and difference has statistical significance (P < 0.05); The dynamic flow rate for the treatment of group radiotherapy terminate 0 week and 4 Zhou Shijun apparently higher than matched group, difference has statistical significance (P < 0.05).In table 2, table 3.

The table 2 liang static flow rate of group patient salivary gland compares

Note: compare with before organizing radiotherapy, ^*p < 0.05

The table 3 liang dynamic flow rate of group patient's salivary gland compares

Note: compare with before organizing radiotherapy, ^*p < 0.05, compared with the matched group same time, ^△p < 0.05

(3) parotid gland uptake ratio (UR) of salivary gland video picture two groups of patients all comparatively declines before radiotherapy to some extent when radiotherapy terminates 0 week and 4 weeks, no significant difference.The different also not statistically significant of the UR value difference of 3 time points between two groups.Two groups of patient ER all comparatively obviously decline before radiotherapy when radiotherapy terminates 0 week and 4 weeks, and difference has statistical significance (P < 0.05); The ER value for the treatment of group when radiotherapy terminates 0 week and 4 weeks is apparently higher than matched group, and difference has statistical significance (P < 0.05).In table 4, table 5.

The comparison of parotid gland UR before and after table 4 liang group patient treatment

The comparison of ER before and after table 5 liang group patient treatment

(4) lab testing all cases check Liver and kidney function does not all find obvious exception, two groups of testing result no significant difference.

In sum, Chinese medicine preparation use safety of the present invention, convenience, effectively can alleviate Nasopharyngeal Carcinoma Patients and accept the xerostomia symptom that radiotherapy causes, can be used as a kind of new treatment means of clinical prevention radioactivity salivary gland damage, and promote.

Detailed description of the invention

Embodiment one: take Flos Impatientis 25g, Radix seu Cortex Heteropanacis Fragrantis 10g, Radix seu cortex rhamni utilis 15g, Herba Salviae Simplicifoliae 15g, thorn stamen grass 25g, Herba Eriae Graminifoliae 7g, Herba Coelogynes 6g, Rhizoma disporopsis pernyi 8g, Fructus Ranunculi Scelerati 4g, Flos Caraganae intermediae 6g, Herba Parnassiae Delavayi 8g, Thamnolia vermicularis (Ach.) Asa-hina 7g, decocting makes decoction.

Embodiment two: take Flos Impatientis 30g, Radix seu Cortex Heteropanacis Fragrantis 5g, Radix seu cortex rhamni utilis 20g, Herba Salviae Simplicifoliae 10g, thorn stamen grass 30g, Herba Eriae Graminifoliae 5g, Herba Coelogynes 8g, Rhizoma disporopsis pernyi 6g, Fructus Ranunculi Scelerati 5g, Flos Caraganae intermediae 4g, Herba Parnassiae Delavayi 10g, Thamnolia vermicularis (Ach.) Asa-hina 5g, decocting makes decoction.

Embodiment three: take Flos Impatientis 20g, Radix seu Cortex Heteropanacis Fragrantis 15g, Radix seu cortex rhamni utilis 10g, Herba Salviae Simplicifoliae 20g, thorn stamen grass 20g, Herba Eriae Graminifoliae 10g, Herba Coelogynes 4g, Rhizoma disporopsis pernyi 10g, Fructus Ranunculi Scelerati 3g, Flos Caraganae intermediae 10g, Herba Parnassiae Delavayi 6g, Thamnolia vermicularis (Ach.) Asa-hina 10g, decocting makes decoction.

Claims

1. treat a Chinese medicine preparation for type of hyperactivity of fire caused by deficiency of YIN radioactivity salivary gland damage, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Flos Impatientis 20-30 part, Radix seu Cortex Heteropanacis Fragrantis 5-15 part, Radix seu cortex rhamni utilis 10-20 part, Herba Salviae Simplicifoliae 10-20 part, thorn stamen grass 20-30 part, Herba Eriae Graminifoliae 5-10 part, Herba Coelogynes 4-8 part, Rhizoma disporopsis pernyi 6-10 part, Fructus Ranunculi Scelerati 3-5 part, Flos Caraganae intermediae 4-10 part, Herba Parnassiae Delavayi 6-10 part, Thamnolia vermicularis (Ach.) Asa-hina 5-10 part.

2. as claimed in claim 1 a kind of treat type of hyperactivity of fire caused by deficiency of YIN radioactivity salivary gland damage Chinese medicine preparation, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Flos Impatientis 25 parts, Radix seu Cortex Heteropanacis Fragrantis 10 parts, Radix seu cortex rhamni utilis 15 parts, Herba Salviae Simplicifoliae 15 parts, thorn stamen grass 25 parts, Herba Eriae Graminifoliae 7 parts, Herba Coelogynes 6 parts, Rhizoma disporopsis pernyi 8 parts, Fructus Ranunculi Scelerati 4 parts, Flos Caraganae intermediae 6 parts, Herba Parnassiae Delavayi 8 parts, Thamnolia vermicularis (Ach.) Asa-hina 7 parts.