CN103977216A

CN103977216A - Traditional Chinese medicinal preparation for treating irradiated brain stem type myeloen cephalospinal disease

Info

Publication number: CN103977216A
Application number: CN201410219580.3A
Authority: CN
Inventors: 魏本正; 鞠发军
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-05-17
Filing date: 2014-05-17
Publication date: 2014-08-13

Abstract

The invention discloses a traditional Chinese medicinal preparation for treating irradiated brain stem type myeloen cephalospinal disease. Traditional Chinese medicine holds that the irradiated brain stem type myeloen cephalospinal disease is characterized by the symptoms of neural paralysis and hemiplegia of corresponding brain stem segments, which are differentially diagnosed in traditional Chinese medicine as Qi-stagnation and blood stasis, veins stagnation and stasis types. Therefore, the traditional Chinese medicinal preparation is prepared by decocting the following traditional Chinese medicinal materials with effects of tonifying qi, activating blood and dredging channels: longspurred fairybells rhizome, Japanese angelica tree root bark, ginkgo root, smilax riparia, smallleaf blueberry fruit, dewberryleaf cinquefoil herb, suffrutescent securinega twig, luffa root, root of acanthopanax ricinifliux seem, and liquorice head. Clinical tests prove that the effective rate of the traditional Chinese medicinal preparation is 93.3 percent and is remarkably superior to that of a control group, and the treatment cost is low, so that the traditional Chinese medicinal preparation is worthy of clinical popularization and application.

Description

A kind of Chinese medicine preparation of radiotherapy brainstem type encephalomyelopathy

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine preparation of radiotherapy brainstem type encephalomyelopathy.

Background technology

IMED is one of severe complication being brought out by radiotherapy, most morbidities (average 18 months) in 12 weeks～5 years after accepting radiotherapy.Its incidence rate is relevant to the sensitivity of lonizing radiation with number of times and the individuality of exposure dose, time, irradiation field size, irradiation.External exposure coup injury marrowbrain tissue is this disease main cause, cause the degeneration of marrowbrain neurocyte, vessel wall thickening, lumen of vessels is diminished, cause obliteration and cause marrowbrain blood supply insufficiency, cause ischemic change, cause surrounding brain tissues to have edema, inflammation tissue infiltration, the pathological change of the de-marrow of nerve fiber and gliosis.IMED main manifestations is pressed the difference of damage location, divides and has brain type, brainstem type, myeloid form.This disease of western medical treatment often adopts hormone therapy, and curative effect is not good enough and side effect is large, and radiotherapy is interrupted and treatment time prolongation can reduce again therapeutic effect.Chinese medicine IMED not only curative effect is affirmed, is had no side effect but also be cheap, for improving body toleration, reduces the incidence rate of IMED, and there is significant curative effect relief of symptoms aspect.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation of radiotherapy brainstem type encephalomyelopathy.The neural paralysis that radioactivity brainstem type encephalomyelopathy shows as corresponding brain stem sections adds hemiplegia symptom.Differential diagnosis in tcm is qi depression to blood stasis, venation block type, and controlling should QI invigorating, invigorate blood circulation, dredging collateral.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this radiotherapy brainstem type encephalomyelopathy is made up of the Chinese medicine of following weight portion: Rhizoma Dispori Calcarati 9-15 part, Cortex Araliae Elatae Radicis 15-25 part, Radix Ginkgo 50-60 part, Radix et Rhizoma Smilacis Ripariae 9-15 part, Herba Vaccinii Bracteati 3-6 part, Herba Potentillae Fragarioidis 9-15 part, a leaf obtain 9-15 part, Radix Luffae 3-9 part, Radix Kalopanacis 9-15 part, Rhizoma Glycyrrhizae uralensis 3-6 part.

Preferably, 12 parts of Rhizoma Dispori Calcaratis, 20 parts of Cortex Araliae Elatae Radiciss, 55 parts of Radix Ginkgos, 12 parts of Radix et Rhizoma Smilacis Ripariae, 4 parts of Herba Vaccinii Bracteati, 12 parts of Herba Potentillae Fragarioidiss, a leaf obtain 12 parts, 6 parts of Radix Luffae, 12 parts of Radix Kalopanacis, 4 parts of Rhizoma Glycyrrhizae uralensiss.

Above-mentioned Chinese medicine decocting is made decoction by preparation method.

Fang Zhong: Rhizoma Dispori Calcarati promoting the production of body fluid and benefiting QI, nourishing YIN and moistening the lung; Cortex Araliae Elatae Radicis invigorating QI and tranquilization, essence strengthening and the kidney invigorating, dispelling, collateral-activating; Radix Ginkgo QI invigorating tonify deficiency; Radix et Rhizoma Smilacis Ripariae QI invigorating, relaxing muscles and tendons and activating QI and blood in the collateral, invigorate blood circulation; The strong muscle QI invigorating of Herba Vaccinii Bracteati, detumescence; Gas, nourishing YIN void in Herba Potentillae Fragarioidis benefit; One leaf Miscanthus sacchariflorus (Maxim) Benth et Hook f relaxing muscles and tendons to promote blood circulation, tonifying speen and tonifying kidney; Radix Luffae is invigorated blood circulation, stimulates the menstrual flow, is subsided a swelling; Radix Kalopanacis dissipating blood stasis removing heat from blood, expelling wind and removing dampness; Rhizoma Glycyrrhizae uralensis clots absorbing blood, detumescence poison.

Clinical data

1, physical data is chosen in January, 2008 to 2010 year December and is moved in 30 routine radioactivity brainstem type encephalomyelopathy patients' of my institute clinical data, wherein male's 17 examples, women's 13 examples, 44 years old～75 years old age, average 56.1 years old.Primary disease is nasopharyngeal carcinoma 18 examples, the esophageal carcinoma 11 examples, lower jaw enamel cell cancer 1 example.After irradiation to symptom time of occurrence be 16～25 weeks 15 examples, 26～78 weeks 15 examples.Be divided at random two groups, two groups at equal no difference of science of statistics in aspect (P > 0.05) such as sex ratio, age, the courses of disease, has comparability.

2, diagnostic criteria (1) has craniofacial tumor or esophageal carcinoma radiation treatment history; (2) radiotherapy finishes to have to clinical symptoms the incubation period of 16～78 weeks; (3) nervous symptoms and sign conform to irradiated site; (4) the visible temporal lobe of head CT inspection, top, thalamus or brain stem have limitation necrosis region; (5) get rid of neoplasm metastasis or recurrence to neural direct infringement.

3, Therapeutic Method matched group patient carries out conventional doctor trained in Western medicine hormone therapy, treatment group patient is on the western medical treatment basis of 1 week, inactive hormone from second week, take Chinese medicine preparation of the present invention, take Rhizoma Dispori Calcarati 12g, Cortex Araliae Elatae Radicis 20g, Radix Ginkgo 55g, Radix et Rhizoma Smilacis Ripariae 12g, Herba Vaccinii Bracteati 4g, Herba Potentillae Fragarioidis 12g, a leaf obtains 12g, Radix Luffae 6g, Radix Kalopanacis 12g, Rhizoma Glycyrrhizae uralensis 4g, decocting becomes decoction, and potion, divided and sooner or later took for 2 times every day.All treat continuously 1 month for two groups.

5, criterion of therapeutical effect is pressed Ping Fenkashi (KPS) standard according to patient's general status.The remission after medication 2 weeks of various symptom reach 80～90 points for effective; After medication 3 weeks symptom improve taking 60～70 points for effective; After medication 4 weeks symptom without improve taking 40～50 points as invalid.

6, therapeutic outcome patient treatment observe the curative effect after 1 month, treatment group 15 examples, wherein effective 11 examples (73.3%), effective 3 examples (20%), invalid 1 example (6.7%), total effective rate 93.3%.Matched group 15 examples, wherein effective 6 examples (40%), effective 5 examples (33.3%), invalid 4 examples (26.7%), total effective rate 73.3%.Two groups of total effective rate comparing differences have significant (P < 0.05), and treatment group therapeutic effect is obviously better than matched group.

Detailed description of the invention

Embodiment mono-: take Rhizoma Dispori Calcarati 12g, Cortex Araliae Elatae Radicis 20g, Radix Ginkgo 55g, Radix et Rhizoma Smilacis Ripariae 12g, Herba Vaccinii Bracteati 4g, Herba Potentillae Fragarioidis 12g, a leaf obtains 12g, Radix Luffae 6g, Radix Kalopanacis 12g, Rhizoma Glycyrrhizae uralensis 4g, and above-mentioned Chinese medicine decocting is become to decoction.

Embodiment bis-: take Rhizoma Dispori Calcarati 15g, Cortex Araliae Elatae Radicis 15g, Radix Ginkgo 60g, Radix et Rhizoma Smilacis Ripariae 9g, Herba Vaccinii Bracteati 6g, Herba Potentillae Fragarioidis 9g, a leaf obtains 15g, Radix Luffae 3g, Radix Kalopanacis 15g, Rhizoma Glycyrrhizae uralensis 3g, and above-mentioned Chinese medicine decocting is become to decoction.

Embodiment tri-: take Rhizoma Dispori Calcarati 9g, Cortex Araliae Elatae Radicis 25g, Radix Ginkgo 50g, Radix et Rhizoma Smilacis Ripariae 15g, Herba Vaccinii Bracteati 3g, Herba Potentillae Fragarioidis 15g, a leaf obtains 9g, Radix Luffae 9g, Radix Kalopanacis 9g, Rhizoma Glycyrrhizae uralensis 6g, and above-mentioned Chinese medicine decocting is become to decoction.

Claims

1. a Chinese medicine preparation for radiotherapy brainstem type encephalomyelopathy, is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Rhizoma Dispori Calcarati 9-15 part, Cortex Araliae Elatae Radicis 15-25 part, Radix Ginkgo 50-60 part, Radix et Rhizoma Smilacis Ripariae 9-15 part, Herba Vaccinii Bracteati 3-6 part, Herba Potentillae Fragarioidis 9-15 part, a leaf obtain 9-15 part, Radix Luffae 3-9 part, Radix Kalopanacis 9-15 part, Rhizoma Glycyrrhizae uralensis 3-6 part.

2. the Chinese medicine preparation of a kind of radiotherapy brainstem type encephalomyelopathy according to claim 1, is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: 12 parts of Rhizoma Dispori Calcaratis, 20 parts of Cortex Araliae Elatae Radiciss, 55 parts of Radix Ginkgos, 12 parts of Radix et Rhizoma Smilacis Ripariae, 4 parts of Herba Vaccinii Bracteati, 12 parts of Herba Potentillae Fragarioidiss, a leaf obtain 12 parts, 6 parts of Radix Luffae, 12 parts of Radix Kalopanacis, 4 parts of Rhizoma Glycyrrhizae uralensiss.