CN103656319B - A kind of external traditional Chinese medicinal application for the treatment of acute radiation-induced esophagitis - Google Patents
A kind of external traditional Chinese medicinal application for the treatment of acute radiation-induced esophagitis Download PDFInfo
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Abstract
The invention discloses a kind of external traditional Chinese medicinal application for the treatment of acute radiation-induced esophagitis.Chinese medicine thinks that swallowing of radiation esophagitis is choked with sobs, and the disease that diet lattice are refused is similar to the disease of ancient doctor's nationality " cancer of the esophagus ".Treatment is with clearing away heat-fire, and removing toxic substances and promoting subsidence of swelling, it is anxious that promoting blood circulation and stopping pain controls its mark, and yin nourishing convergence granulation promoting controls its deficiency in origin.The present invention selects Chinese medicine Herba Lophatheri, Gentiana pubigera Marquand, Herba cassiae occidentalis, Spica Prunellae, the Radix Pulsatillae, Radix Lactucae Indicae, Herba Sebi drymarioidis, Flos Bougainvillea Glabrae, Radix Luculiae intermediae, Rhizoma Polygoni sinensis, Caulis Roureae Microphyllae, Radix Antiotrematis dunniani, pulverization, make externally dressing, through clinical trial, total effective rate reaches 97.6%, is obviously better than 70% of matched group.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of external traditional Chinese medicinal application for the treatment of acute radiation-induced esophagitis.
Background technology
Carrying out in radiotherapy to thoracic malignant tumors patient, when irradiation 1 ~ 2 weekly dose reaches 10 ~ 20Gy, can there is hyperemia, edema in the normal esophageal mucosa in irradiation field, occur dysphagia; After exposure dose reaches 30 ~ 40Gy, mucous membrane of esophagus hyperemia increases the weight of further, and show as burn feeling after local pain or breastbone, severe one is difficult to stand, and is work time especially to take food, and is clinically referred to as radiation esophagitis.For the treatment of radiation injury, all in all western medical treatment means fail to depart from antibiotic, Metabolism, Vitamins and Hormones " three elements " category.Administering mode adopts form that is oral or atomization more.Though these class methods effectively can alleviate partial symptoms, its side effect is also comparatively obvious, as immunological function repression, increase the weight of or bounce after bringing out infection, dysbacteriosis, digestive tract hemorrhage, drug withdrawal, and late result is not good enough.The traditional Chinese medical science has also carried out a large amount of explorations in radiotherapy esophagitis, and have accumulated good experience.The traditional Chinese medical science, Chinese medicine serve comprehensive opsonic action, and it not only can easing oesophagus pain scorching itself, and can treat other radiation complication to some extent, regulates the integrality of body, have immunoregulatory function simultaneously.Acupuncture points external application agent is applicable to prevent and treat radiation esophagitis, and in therapeutic process, patient reacts without discomfort, and without contraindication, the early stage analgesic effect of medication is obvious, and patient is easy to accept; Chinese herbal medicine is cheap, can preserve under room temperature.
Summary of the invention
The object of this invention is to provide a kind of external traditional Chinese medicinal application for the treatment of acute radiation-induced esophagitis.Chinese medicine thinks that swallowing of radiation esophagitis is choked with sobs, and the disease that diet lattice are refused is similar to the disease of ancient doctor's nationality " cancer of the esophagus ".Treatment is with clearing away heat-fire, and removing toxic substances and promoting subsidence of swelling, it is anxious that promoting blood circulation and stopping pain controls its mark, and yin nourishing convergence granulation promoting controls its deficiency in origin.
The object of the invention is to be achieved through the following technical solutions, the external traditional Chinese medicinal application of this treatment acute radiation-induced esophagitis is made up of the Chinese medicine of following weight portion: Herba Lophatheri 10-14 part, Gentiana pubigera Marquand 9-15 part, Herba cassiae occidentalis 6-9 part, Spica Prunellae 5-15 part, Radix Pulsatillae 9-15 part, Radix Lactucae Indicae 15-30 part, Herba Sebi drymarioidis 25-32 part, Flos Bougainvillea Glabrae 9-15 part, Radix Luculiae intermediae 20-25 part, Rhizoma Polygoni sinensis 3-9 part, Caulis Roureae Microphyllae 7-10 part, Radix Antiotrematis dunniani 9-15 part.
Preferred: Herba Lophatheri 12 parts, Gentiana pubigera Marquand 12 parts, Herba cassiae occidentalis 8 parts, Spica Prunellae 10 parts, the Radix Pulsatillae 12 parts, Radix Lactucae Indicae 20 parts, Herba Sebi drymarioidis 28 parts, Flos Bougainvillea Glabrae 12 parts, Radix Luculiae intermediae 23 parts, Rhizoma Polygoni sinensis 6 parts, Caulis Roureae Microphyllae 8.5 parts, Radix Antiotrematis dunniani 12 parts.
Preparation method is by for subsequent use for above-mentioned Chinese medicine pulverization.
Fang Zhong: Herba Lophatheri heat clearing away is except fire; Gentiana pubigera Marquand resolving heat and reducing pathogenic fire; Herba cassiae occidentalis removing liver heat and toxic substances; Spica Prunellae liver heat removing eliminating stagnation; Radix Pulsatillae heat-clearing and toxic substances removing; Radix Lactucae Indicae, Herba Sebi drymarioidis removing toxic substances and promoting subsidence of swelling, Flos Bougainvillea Glabrae, Radix Luculiae intermediae promoting blood circulation and stopping pain; The convergence of Rhizoma Polygoni sinensis, Caulis Roureae Microphyllae granulation promoting, Radix Antiotrematis dunniani yin nourishing tonify deficiency.
Clinical data
1. the routine patient of physical data 60 is the patient that the court's radiotherapy department accepts radiotherapy to the chest, and wherein the esophageal carcinoma 39 example, pulmonary carcinoma 21 example, be all acute radiation-induced esophagitis through clinical diagnosis, be divided into treatment group and matched group.Two groups all adopt three dimensional conformal radiation therapy or intensity modulated radiation therapy.Treatment group 30 example, man 18 example, female 12 example, 58.5 years old mean age, radiotherapy accumulated dose 58 ~ 65Gy, length of esophagus 5 ~ 15cm in irradiation field, the esophageal carcinoma 20 example, pulmonary carcinoma 10 example; Matched group 30 example, man 20 example, female 10 example, 59.6 years old mean age, radiotherapy accumulated dose 58 ~ 64Gy, length of esophagus 5 ~ 13cm in irradiation field, the esophageal carcinoma 19 example, pulmonary carcinoma 11 example; The clinical factors such as two groups of patient ages, sex, histological type analyze not statistically significant (P > 0.05), have comparability.
2. diagnostic criteria (1) has breast tumor radiotherapy history or is carrying out radiotherapy.(2) clinical manifestation: mediastinal tumor, the non-esophagus disease such as pulmonary carcinoma occurs and the retrosternal pain of primary disease without direct relation in Patients During Radiotherapy, and feed burn feeling, swallows discomfort, and feed pain appears in severe patient, thus fears feed.In radiotherapy in esophageal carcinoma patients except there is above-mentioned symptom, eating difficulties obviously increases the weight of before comparatively treating.Have a medical check-up general without obvious sign.(3) esophagogram shows that mucosa is disorderly, and block and increase the weight of, tube chamber is less.The visible exposure mucous membrane of esophagus of endoscopy is congested, edema, and even pseudomembrane is formed.
3. Therapeutic Method treatment group patient adopts acupuncture points external application method to treat, take Herba Lophatheri 12g, Gentiana pubigera Marquand 12g, Herba cassiae occidentalis 8g, Spica Prunellae 10g, Radix Pulsatillae 12g, Radix Lactucae Indicae 20g, Herba Sebi drymarioidis 28g, Flos Bougainvillea Glabrae 12g, Radix Luculiae intermediae 23g, Rhizoma Polygoni sinensis 6g, Caulis Roureae Microphyllae 8.5g, Radix Antiotrematis dunniani 12g, smash above-mentioned Chinese medicine to pieces pulverization, paste is reconciled into Mel, the sterile gauze being applied in 3 thickness with spatula equably makes plaster, thickness is 1 ~ 2mm about, then plaster is spread on the medium acupuncture point of tsu san li, Tiantu and wingceltis, properly fixing, change 1 every day; The gargarism that during matched group radiation treatment, conventional application normal saline, sodium bicarbonate, lignocaine are made into is gargled or buccal to patient.
4. criterion of therapeutical effect is effective: swallow pain and dysphagia disappears substantially; Effective: to swallow pain and (or) dysphagia obviously alleviates; Invalid: to swallow pain and dysphagia slightly alleviates or without improvement.
5. therapeutic effect two groups of patients treat observe the curative effect after 10 days continuously, in treatment group 30 example, and wherein effective 20 examples (66.7%), effective 9 examples (30%), invalid 1 example (3.3%), total effective rate is 96.7%; In matched group 30 example, wherein effective 10 examples (33.3%), effective 11 examples (36.7%), no effect 9 (30%), total effective rate is 70%.Two groups of total effective rate comparing differences have significant (P < 0.05), and treatment group therapeutic effect is obviously better than matched group.
Detailed description of the invention
Embodiment one: take Herba Lophatheri 12g, Gentiana pubigera Marquand 12g, Herba cassiae occidentalis 8g, Spica Prunellae 10g, Radix Pulsatillae 12g, Radix Lactucae Indicae 20g, Herba Sebi drymarioidis 28g, Flos Bougainvillea Glabrae 12g, Radix Luculiae intermediae 23g, Rhizoma Polygoni sinensis 6g, Caulis Roureae Microphyllae 8.5g, Radix Antiotrematis dunniani 12g, by for subsequent use for above-mentioned Chinese medicine pulverization.
Embodiment two: take Herba Lophatheri 10g, Gentiana pubigera Marquand 15g, Herba cassiae occidentalis 6g, Spica Prunellae 15g, Radix Pulsatillae 9g, Radix Lactucae Indicae 30g, Herba Sebi drymarioidis 25g, Flos Bougainvillea Glabrae 15g, Radix Luculiae intermediae 20g, Rhizoma Polygoni sinensis 9g, Caulis Roureae Microphyllae 10g, Radix Antiotrematis dunniani 15g.By for subsequent use for above-mentioned Chinese medicine pulverization.
Embodiment three: take Herba Lophatheri 14g, Gentiana pubigera Marquand 9g, Herba cassiae occidentalis 9g, Spica Prunellae 5g, Radix Pulsatillae 15g, Radix Lactucae Indicae 15g, Herba Sebi drymarioidis 32g, Flos Bougainvillea Glabrae 9g, Radix Luculiae intermediae 25g, Rhizoma Polygoni sinensis 3g, Caulis Roureae Microphyllae 7g, Radix Antiotrematis dunniani 9g.By for subsequent use for above-mentioned Chinese medicine pulverization.
Claims (2)
1. treat an external traditional Chinese medicinal application for acute radiation-induced esophagitis, it is characterized in that this external traditional Chinese medicinal application is made up of the Chinese medicine of following weight portion: Herba Lophatheri 10-14 part, Gentiana pubigera Marquand 9-15 part, Herba cassiae occidentalis 6-9 part, Spica Prunellae 5-15 part, Radix Pulsatillae 9-15 part, Radix Lactucae Indicae 15-30 part, Herba Sebi drymarioidis 25-32 part, Flos Bougainvillea Glabrae 9-15 part, Radix Luculiae intermediae 20-25 part, Rhizoma Polygoni sinensis 3-9 part, Caulis Roureae Microphyllae 7-10 part, Radix Antiotrematis dunniani 9-15 part.
2. a kind of external traditional Chinese medicinal application for the treatment of acute radiation-induced esophagitis according to claim 1, is characterized in that this external traditional Chinese medicinal application is made up of the Chinese medicine of following weight portion: Herba Lophatheri 12 parts, Gentiana pubigera Marquand 12 parts, Herba cassiae occidentalis 8 parts, Spica Prunellae 10 parts, the Radix Pulsatillae 12 parts, Radix Lactucae Indicae 20 parts, Herba Sebi drymarioidis 28 parts, Flos Bougainvillea Glabrae 12 parts, Radix Luculiae intermediae 23 parts, Rhizoma Polygoni sinensis 6 parts, Caulis Roureae Microphyllae 8.5 parts, Radix Antiotrematis dunniani 12 parts.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1424071A (en) * | 2002-12-13 | 2003-06-18 | 济南市第四人民医院 | Auxiliary medicine for treating esophagus cancer and processing method thereof |
| CN103110898A (en) * | 2013-02-15 | 2013-05-22 | 叶蕾 | Preparation method of traditional Chinese medicine for treating heat toxicity type reflux oesophagitis |
| CN103386101A (en) * | 2013-06-25 | 2013-11-13 | 管丽 | Traditional Chinese medicine preparation for nonspecific cystitis treatment and preparation method thereof |
| CN103405663A (en) * | 2013-07-10 | 2013-11-27 | 李俊萍 | Chinese medicine composition for aiding radiotherapy |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1424071A (en) * | 2002-12-13 | 2003-06-18 | 济南市第四人民医院 | Auxiliary medicine for treating esophagus cancer and processing method thereof |
| CN103110898A (en) * | 2013-02-15 | 2013-05-22 | 叶蕾 | Preparation method of traditional Chinese medicine for treating heat toxicity type reflux oesophagitis |
| CN103386101A (en) * | 2013-06-25 | 2013-11-13 | 管丽 | Traditional Chinese medicine preparation for nonspecific cystitis treatment and preparation method thereof |
| CN103405663A (en) * | 2013-07-10 | 2013-11-27 | 李俊萍 | Chinese medicine composition for aiding radiotherapy |
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