CN113827687A

CN113827687A - Traditional Chinese medicine formula preparation for treating thyroid nodule and preparation method thereof

Info

Publication number: CN113827687A
Application number: CN202111312408.9A
Authority: CN
Inventors: 陈飞; 盖应丽; 祝星宇
Original assignee: Heilongjiang University of Chinese Medicine
Current assignee: Heilongjiang University of Chinese Medicine
Priority date: 2021-11-08
Filing date: 2021-11-08
Publication date: 2021-12-24
Anticipated expiration: 2041-11-08
Also published as: CN113827687B

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine formula preparation for treating thyroid nodules and a preparation method thereof. The traditional Chinese medicine prescription preparation comprises the following raw materials: selfheal, spreading hedyotis herb, Indian iphigenia bulb, Chinese angelica, thunberg fritillary bulb, dandelion, spina gleditsiae, radix curcumae, semen cuscutae, curcuma zedoary, trumpet creeper, platycodon grandiflorum, figwort and liquorice. According to the invention, through reasonable compatibility of the traditional Chinese medicine raw materials and optimized preparation process, the traditional Chinese medicine formula preparation can effectively improve the nodule symptoms of patients, and has high clinical application value. The traditional Chinese medicine composition has the effects of removing stasis and eliminating goiter, soothing liver and relieving depression, and promoting blood circulation to remove blood stasis, can obviously inhibit and reduce thyroid nodules of a patient, does not influence the level of first function of the patient, and has high safety and no toxic or side effect.

Description

Traditional Chinese medicine formula preparation for treating thyroid nodule and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine formula preparation for treating thyroid nodules and a preparation method thereof.

Background

In clinic, thyroid nodules are a very common disease, mainly due to increased pituitary TSH secretion caused by the relative presence of thyroid hormones in vivo, causing recurrent thyroid hyperplasia with various degenerative changes, thereby forming nodules. The diseased group of thyroid nodules is mainly female, more than half of thyroid nodules are benign nodules, while malignant nodules are about 5% -15%, and the benign nodules also have the risk of transforming into malignancy. People who develop this type of disease must be treated as early as possible, without delay. Thyroid nodules belong to 'flesh goiter and goiter' caused by improper diet and emotional internal injury in the category of traditional Chinese medicine.

Goiter is a disease characterized by lump and swelling on both sides of the anterior laryngeal prominence of the neck. Modern medicine believes that the pathogenesis of thyroid nodules can increase with age and decrease with decreased iodine intake. In traditional Chinese medicine, goiter can be caused by emotional internal injury, diet, water and soil incompatibility or constitutional factors. A large number of literature studies of ancient and modern Chinese medicine show that long-term depression and anxiety, stagnation of qi, liver qi disorder, spleen dysfunction in transportation, dampness accumulation and phlegm generation, qi stagnation and phlegm coagulation in front of the neck for a long time form thyroid nodules. In the initial stage, stagnation of qi activity, accumulation of fluid and phlegm, phlegm-qi stagnation in the neck, long-term stagnation of blood and qi, phlegm and blood stasis are all the causes. The disease is characterized by the liver and spleen, which are connected to the heart. Stagnation of qi is caused by stagnation of liver qi, stagnation of qi is caused by spleen injury, fluid is stopped due to stagnation of qi, phlegm dampness is caused by spleen deficiency, phlegm-qi is mixed and blocked, blood circulation is not smooth, and qi-blood phlegm is accumulated to form goiter. Long-term goiter can damage liver yin and heart yin, accompanied by palpitation, dysphoria, and rapid pulse. Through treatment based on syndrome differentiation, the types of syndromes are differentiated according to qi and blood, yin and yang and pathogenic qi, so that the accurate therapeutic principle is provided for the symptoms. The method for treating benign simple thyroid nodules by adopting traditional Chinese medicines has certain advantages, basically adopts the methods of regulating qi, resolving masses, softening and resolving hard masses, soothing liver, resolving stagnation, activating blood and removing stasis, reduces or even eliminates the thyroid nodules, improves the clinical symptoms of patients, and still has the problems of poor curative effect, long time and the like.

Disclosure of Invention

In order to solve the technical problems, the invention provides a traditional Chinese medicine formula preparation for treating thyroid nodules and a preparation method thereof. Through reasonable compatibility of the traditional Chinese medicine raw materials and optimized preparation process, the traditional Chinese medicine formula preparation can effectively improve the nodule symptoms of patients and has high clinical application value.

In order to achieve the purpose, the invention adopts the technical scheme that:

a traditional Chinese medicine formula preparation for treating thyroid nodules comprises the following raw materials in parts by weight: 20-40 parts of selfheal, 20-40 parts of oldenlandia diffusa, 15-35 parts of edible tulip, 10-30 parts of angelica, 10-20 parts of thunberg fritillary bulb, 5-20 parts of dandelion, 5-20 parts of spina gleditsiae, 5-15 parts of radix curcumae, 5-15 parts of semen cuscutae, 5-10 parts of curcuma zedoary, 5-10 parts of campsis grandiflora, 5-10 parts of platycodon grandiflorum, 10-20 parts of radix scrophulariae and 10-20 parts of liquorice.

Preferably, the traditional Chinese medicine formula preparation comprises the following raw materials in parts by weight: 25-35 parts of selfheal, 25-35 parts of spreading hedyotis herb, 20-30 parts of Indian iphigenia bulb, 15-25 parts of Chinese angelica, 12-18 parts of thunberg fritillary bulb, 10-15 parts of dandelion, 10-15 parts of spina gleditsiae, 8-12 parts of turmeric root-tuber, 8-12 parts of Chinese dodder seed, 6-9 parts of zedoary, 6-9 parts of Chinese trumpet creeper flower, 6-9 parts of platycodon grandiflorum, 12-18 parts of figwort root and 12-18 parts of liquorice.

Preferably, the traditional Chinese medicine formula preparation comprises the following raw materials in parts by weight: 30 parts of selfheal, 30 parts of oldenlandia diffusa, 25 parts of edible tulip, 20 parts of angelica, 15 parts of thunberg fritillary bulb, 12 parts of dandelion, 12 parts of spina gleditsiae, 10 parts of radix curcumae, 10 parts of semen cuscutae, 8 parts of curcuma zedoary, 8 parts of trumpet creeper, 8 parts of platycodon grandiflorum, 15 parts of radix scrophulariae and 15 parts of liquorice.

Preferably, the traditional Chinese medicine prescription preparation is pills or capsules.

Further, the invention also provides a preparation method of the traditional Chinese medicine prescription preparation, the traditional Chinese medicine prescription preparation is a pill, and the preparation method comprises the following specific steps:

(1) weighing the traditional Chinese medicine raw materials according to the parts by weight, cleaning, and drying at 35-45 ℃ for later use;

(2) uniformly mixing dried edible tulip, thunberg fritillary bulb, semen cuscutae, trumpet creeper, figwort root and liquorice, grinding and crushing into fine powder, and sieving with a sieve of 100-mesh and 120-mesh to obtain medicinal powder A;

(3) uniformly mixing the dried prunella vulgaris, oldenlandia diffusa, angelica sinensis, dandelion, spina gleditsiae, radix curcumae, curcuma zedoary and platycodon grandiflorum, adding purified water which is 3-5 times of the total weight of the raw materials, decocting for 3 times, wherein each time lasts for 1-2 hours, merging the filtrates, concentrating under reduced pressure until the relative density of the extract is 1-1.2, drying the extract at 35-45 ℃, grinding and crushing the extract into fine powder, and sieving the fine powder with a 100-mesh 120-mesh sieve to obtain medicinal powder B;

(4) mixing the powder A and B with appropriate amount of binder, making into pill, packaging, and storing.

Further, the invention also provides a preparation method of the traditional Chinese medicine prescription preparation, the traditional Chinese medicine prescription preparation is a capsule, and the preparation method specifically comprises the following steps:

(4) mixing powder A, powder B and appropriate amount of magnesium stearate, encapsulating to obtain capsule, packaging, and storing.

Selfheal: pungent and bitter in flavor and cold in nature, it enters liver and gallbladder meridians. The efficacy is as follows: clear fire, improve vision, dissipate nodulation and resolve swelling. Can be used for treating conjunctival congestion, swelling and pain, eyeball nyctalgia, headache, giddiness, scrofula, goiter, mammary abscess, and swelling and pain; goiter, tuberculous lymphadenitis, hyperplasia of mammary glands, and hypertension.

Herba Hedyotidis Diffusae: sweet and light in flavor, cool in nature, entering stomach, large intestine and small intestine meridians. The efficacy is as follows: clearing away heat and toxic material, inducing diuresis to alleviate edema, promoting blood circulation to stop pain. Can be used for treating intestinal carbuncle (appendicitis), skin ulcer, furuncle, toxic swelling, jaundice due to damp-heat, and dysuresia; it is externally used for treating sore, furuncle, carbuncle, swelling, and venomous snake bite.

And (3) edible tulip: sweet and slightly pungent in flavor, cool in nature, entering liver and spleen meridians. The efficacy is as follows: clear heat and remove toxicity, resolve phlegm and dissipate nodulation. Can be used for treating carbuncle, furuncle, scrofula, subcutaneous nodule, lymphoid tuberculosis, snake and insect bite.

Chinese angelica: sweet and pungent in flavor, warm in nature, entering liver, heart and spleen meridians. The efficacy is as follows: tonify blood, activate blood, regulate menstruation, alleviate pain, moisten intestines to relieve constipation. Can be used for treating blood deficiency, sallow complexion, giddiness, palpitation, menoxenia, amenorrhea, dysmenorrhea, asthenia cold, abdominal pain, constipation due to intestinal dryness, rheumatic arthralgia, traumatic injury, superficial infection, pyocutaneous disease. The wine angelica sinensis can activate blood and promote menstruation.

Thunberg fritillary bulb: bitter in taste and cold in nature, it enters lung and heart meridians. The efficacy is as follows: clear heat, resolve phlegm, relieve cough, remove toxicity, dissipate nodulation and cure abscess. Can be used for treating cough due to wind-heat evil, phlegm-fire cough, pulmonary abscess, acute mastitis, scrofula, and sore.

Dandelion: bitter and sweet in flavor, cold in nature, entering liver and stomach meridians. The efficacy is as follows: clearing away heat and toxic material, dispersing swelling and dissipating stagnation, inducing diuresis and treating stranguria. Can be used for treating furuncle, pyogenic infection, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, pulmonary abscess, intestinal abscess, jaundice due to damp-heat pathogen, and stranguria with damp-heat pathogen.

Spina gleditsiae: pungent in flavor and warm in nature, it enters liver and stomach meridians. The efficacy is as follows: detumescence, expelling toxin, expelling pus and killing parasites. Can be used for treating early carbuncle and cellulitis or suppurative abscess; it is indicated for external treatment of scabies and leprosy.

Turmeric root-tuber: pungent and bitter in flavor and cold in nature, it enters liver, heart and lung meridians. The efficacy is as follows: move qi and remove blood stasis, clear heart fire and relieve depression, promote bile flow and cure jaundice. Can be used for treating amenorrhea, dysmenorrhea, chest and abdomen distention and pain, pricking pain, fever unconsciousness, epilepsy, jaundice, and dark urine.

Dodder seed: sweet in flavor and warm in nature, it enters liver, kidney and spleen meridians. The efficacy is as follows: nourishing liver and kidney, arresting seminal emission, arresting polyuria, preventing miscarriage, improving eyesight, and relieving diarrhea. Can be used for treating sexual impotence, spermatorrhea, enuresis, frequent micturition, soreness of waist and knees, blurred vision, tinnitus, fetal leakage due to kidney deficiency, threatened abortion, and spleen and kidney deficiency; externally treat vitiligo.

Zedoary turmeric: pungent and bitter in flavor, warm in nature, entering liver and spleen meridians. The efficacy is as follows: move qi and break blood, resolve food stagnation and alleviate pain. It can be used for treating abdominal mass, blood stasis, amenorrhea, food stagnation, and pain.

Chinese trumpet creeper: sweet and sour in flavor, cold in nature, entering liver and pericardium meridian. The efficacy is as follows: cool blood, remove blood stasis, dispel wind. Can be used for treating menoxenia, amenorrhea, abdominal mass, puerperal breast swelling, rubella, skin pruritus, and acne.

Balloon flower: bitter and pungent in flavor, neutral in nature, enter lung meridian. The efficacy is as follows: disperse lung qi, relieve sore throat, dispel phlegm, and expel pus. Can be used for treating cough with excessive phlegm, chest distress, pharyngalgia, hoarseness, lung carbuncle, suppuration, and pyocutaneous disease with pus formation.

Figwort root: sweet, bitter, salty and slightly cold in nature, entering lung, stomach and kidney meridians. The efficacy is as follows: cool blood and nourish yin, purge fire and remove toxicity. It can be used for treating yin impairment due to febrile disease, crimson tongue with polydipsia, toxic heat, macula, constipation due to body fluid consumption, bone steaming, overstrain cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle, and suppurative sore.

Licorice root: sweet in flavor, neutral in nature, and entering heart, lung, spleen and stomach meridians. The efficacy is as follows: invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the drugs. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.

Compared with the prior art, the invention has the beneficial effects that: through reasonable compatibility of the traditional Chinese medicine raw materials and optimized preparation process, the traditional Chinese medicine formula preparation can effectively improve the nodule symptoms of patients and has high clinical application value. Specifically, selfheal, spreading hedyotis herb, Indian iphigenia bulb, thunberg fritillary bulb, dandelion, spina gleditsiae, figwort root, radix scrophulariae, herba silenes fortunei, heat-clearing and detoxifying are monarch drugs; the Chinese angelica and the trumpet creeper flower have the functions of promoting blood circulation to remove blood stasis, and the platycodon grandiflorum has the functions of tonifying spleen and reducing phlegm, and are ministerial drugs; the turmeric root tuber, the dodder seed and the zedoary are used as adjuvant drugs for soothing the liver and regulating the flow of qi: the liquorice is used as a guiding drug for harmonizing the effects of promoting qi circulation, resolving stagnation, regulating qi and eliminating phlegm in the recipe of the other drugs. The traditional Chinese medicine composition has the effects of removing stasis and eliminating goiter, soothing liver and relieving depression, and promoting blood circulation to remove blood stasis, can obviously inhibit and reduce thyroid nodules of a patient, does not influence the level of first function of the patient, and has high safety and no toxic or side effect.

Detailed Description

The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. The materials, reagents and the like used are, unless otherwise specified, commercially available reagents and materials.

Example 1

A traditional Chinese medicine formula preparation for treating thyroid nodules comprises the following raw materials in parts by weight: 40 parts of selfheal, 20 parts of oldenlandia diffusa, 15 parts of edible tulip, 30 parts of angelica, 10 parts of thunberg fritillary bulb, 5 parts of dandelion, 5 parts of spina gleditsiae, 5 parts of radix curcumae, 5 parts of semen cuscutae, 5 parts of curcuma zedoary, 5 parts of campsis grandiflora, 5 parts of platycodon grandiflorum, 10 parts of radix scrophulariae and 10 parts of liquorice.

The traditional Chinese medicine prescription preparation is a capsule, and the preparation method comprises the following specific steps:

(1) weighing the traditional Chinese medicine raw materials in parts by weight, cleaning, and drying at 35 ℃ for later use;

(2) uniformly mixing dried edible tulip, thunberg fritillary bulb, semen cuscutae, trumpet creeper, figwort root and liquorice, grinding and crushing into fine powder, and sieving with a 100-mesh sieve to obtain medicinal powder A;

(3) uniformly mixing the dried prunella vulgaris, oldenlandia diffusa, angelica sinensis, dandelion, spina gleditsiae, radix curcumae, curcuma zedoary and platycodon grandiflorum, adding purified water with the weight 3 times of the total weight of the raw materials, decocting for 3 times and 2 hours each time, combining filtrates, concentrating under reduced pressure until the relative density of the extract is 1, drying the extract at 35 ℃, grinding and crushing the extract into fine powder, and sieving the fine powder with a 100-mesh sieve to obtain medicinal powder B;

Example 2

A traditional Chinese medicine formula preparation for treating thyroid nodules comprises the following raw materials in parts by weight: 20 parts of selfheal, 40 parts of oldenlandia diffusa, 35 parts of edible tulip, 10 parts of angelica, 20 parts of thunberg fritillary bulb, 20 parts of dandelion, 20 parts of spina gleditsiae, 15 parts of radix curcumae, 15 parts of semen cuscutae, 10 parts of curcuma zedoary, 10 parts of trumpetcreeper flower, 10 parts of platycodon grandiflorum, 20 parts of radix scrophulariae and 20 parts of liquorice.

(1) weighing the traditional Chinese medicine raw materials in parts by weight, cleaning, and drying at 45 ℃ for later use;

(2) uniformly mixing dried edible tulip, thunberg fritillary bulb, semen cuscutae, trumpet creeper, figwort root and liquorice, grinding and crushing into fine powder, and sieving with a 120-mesh sieve to obtain medicinal powder A;

(3) uniformly mixing the dried prunella vulgaris, oldenlandia diffusa, angelica sinensis, dandelion, spina gleditsiae, radix curcumae, curcuma zedoary and platycodon grandiflorum, adding purified water which is 5 times of the total weight of the raw materials, decocting for 3 times and 1 hour each time, combining filtrates, concentrating under reduced pressure until the relative density of the extract is 1.2, drying the extract at 45 ℃, grinding the extract into fine powder, and sieving with a 120-mesh sieve to obtain medicinal powder B;

Example 3

A traditional Chinese medicine formula preparation for treating thyroid nodules comprises the following raw materials in parts by weight: 30 parts of selfheal, 30 parts of oldenlandia diffusa, 25 parts of edible tulip, 20 parts of angelica, 15 parts of thunberg fritillary bulb, 12 parts of dandelion, 12 parts of spina gleditsiae, 10 parts of radix curcumae, 10 parts of semen cuscutae, 8 parts of curcuma zedoary, 8 parts of trumpet creeper, 8 parts of platycodon grandiflorum, 15 parts of radix scrophulariae and 15 parts of liquorice.

(1) weighing the traditional Chinese medicine raw materials in parts by weight, cleaning, and drying at 40 ℃ for later use;

(2) uniformly mixing dried edible tulip, thunberg fritillary bulb, semen cuscutae, trumpet creeper, figwort root and liquorice, grinding and crushing into fine powder, and sieving with a 110-mesh sieve to obtain medicinal powder A;

(3) uniformly mixing the dried prunella vulgaris, oldenlandia diffusa, angelica sinensis, dandelion, spina gleditsiae, radix curcumae, curcuma zedoary and platycodon grandiflorum, adding purified water with the weight 4 times of the total weight of the raw materials, decocting for 3 times, decocting for 1.5 hours each time, combining filtrates, concentrating under reduced pressure until the relative density of an extract is 1.1, drying the extract at 40 ℃, grinding the extract into fine powder, and sieving the fine powder with a 110-mesh sieve to obtain medicinal powder B;

Influence of traditional Chinese medicine composition preparation on apoptosis and angiogenesis of thyroid tumor cells of rats

60 Kunming rats were randomly divided into 6 groups of 10 rats each, and the groups were designated as a normal group, a model control group, a Youmele administration group, and administration groups in examples 1 to 3. Normal group: normal saline is infused; the rest groups are as follows: the solution was prepared into 0.1% propylthiouracil solution with normal saline, and each rat was administered with 100mg/kg daily for 10 weeks. The color ultrasound of the thyroid gland shows that the thyroid lumps appear in the rat, and the molding is successful.

From week 11, the group administered Youmeile was administered with a medicinal solution of 0.1mg/L per day at a body mass of 100mg/kg, the group administered examples 1-3 was administered with a mixed medicinal powder solution of the capsules of examples 1-3 at a body mass of 100mg/kg per day, and the model control group was administered with a physiological saline solution. Gavage was performed 1 time a day in the morning, and after 8 weeks, the rats were sacrificed and their bilateral thyroid glands were removed and stored at low temperature. The apoptosis level in the thyroid tumor of the rat is detected by adopting a flow cytometer Annexin V/PI double staining method. The results of the experiments for detecting the VEGF content in the serum by ELISA method are shown in Table 1-2.

TABLE 1 proportion of apoptotic cells in thyroid tumors in rats of each group (%)

As can be seen from the experimental results of table 1, the proportion of apoptotic cells of the thyroid cells of the rats of the model control group was significantly reduced compared to the normal group, which demonstrates that the accumulation of thyroid nodule tumor was not easily dissipated. Compared with the model control group, the proportion of apoptotic cells of the thyroid cells of rats in the Youmele administration group and the examples 1 to 3 administration group is remarkably increased, and the proportion of apoptotic cells in the examples 1 to 3 administration group is higher, which confirms that the traditional Chinese medicine composition preparation of the invention can effectively promote apoptosis in thyroid lumps of rats.

TABLE 2 VEGF concentrations (pg/ml) in serum of rats of each group

As can be seen from the results in table 2, the concentration of VEGF in the serum of the rats of the model control group was significantly increased compared to the normal group, which demonstrates that the blood flow of the thyroid tissue is abundant and a large amount of neovascularization is expected. Compared with the model control group, the concentration of VEGF in the serum of rats in the Youmele administration group and the examples 1 to 3 administration groups is obviously reduced, and the reduction ratio in the examples 1 to 3 administration groups is more obvious and is closer to the value of the normal group, which proves that the traditional Chinese medicine formula preparation can effectively inhibit the proliferation of the nodular thyroid lumps.

Clinical results experiment

Clinical data: a total of 80 outpatient 18-60 year old thyroid nodule patients were collected with a mean age of 32.6 years, of which: 28 men and 52 women. The groups were randomized into four groups of 20 people each. The traditional Chinese medicine diagnosis standard is as follows: is mainly made by referring to the relevant contents of 'blood stasis and phlegm coagulation type' gall disease in 2007 edition of traditional Chinese medicine internal science and 2002 edition of clinical research guiding principles of new traditional Chinese medicines. Inclusion criteria were: the diagnosis standard of blood stasis and phlegm coagulation type of nodular goiter is met, the functions of heart, kidney and liver are basically normal, and no hereditary, infectious and malignant tumor diseases exist. The treatment method comprises the following steps: treatment groups 1 to 3 were administered 2 capsules per time for 3 days each, with the capsules prepared in examples 1 to 3 of the present invention, respectively; the control group was administered with a commercially available pharmaceutical product, Youmele tablet (manufactured by Merck), 1 tablet (25. mu.g dose) daily in the morning. 3 months is a treatment course, and the treatment effect is measured after the treatment course is expired.

(1) The maximum diameter (cm) of the thyroid nodule was measured using a color doppler flow imager and the results are shown in table 2.

TABLE 2 comparison of thyroid nodule maximum diameter (cm) before and after treatment

As can be seen from the results in Table 2, the treatment group patients who took the capsules of examples 1 to 3 of the present invention for three months were able to effectively reduce the maximum diameter of thyroid nodules in the patients, wherein the treatment effect of example 3 was the best. In contrast, the control group of patients taking the Youmele tablet had no significant change in the maximum diameter of the thyroid nodule.

(2) The thyroid function level was measured, and the results are shown in table 3.

TABLE 3 comparison of thyroid function levels ((FT3, FT4, TSH) before and after treatment

As can be seen from the results in Table 3, the thyroid function levels of the patients in the treatment group remained substantially unchanged for three months after taking the capsules of examples 1 to 3 of the present invention. In contrast, the TSH levels in the control group of patients taking the eumet tablet were significantly reduced compared to before treatment, indicating an impaired level of thyroid function.

In conclusion, the traditional Chinese medicine formula preparation can effectively improve the nodule symptoms of patients through reasonable compatibility of the traditional Chinese medicine raw materials and optimized preparation process, and has high clinical application value. The traditional Chinese medicine composition has the effects of removing stasis and eliminating goiter, soothing liver and relieving depression, and promoting blood circulation to remove blood stasis, can obviously inhibit and reduce thyroid nodules of a patient, does not influence the level of first function of the patient, and has high safety and no toxic or side effect.

The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications or equivalents may be made to the technical solution without departing from the principle of the present invention, and these modifications or equivalents should also be regarded as the protection scope of the present invention.

Claims

1. A traditional Chinese medicine formula preparation for treating thyroid nodules is characterized by comprising the following raw materials in parts by weight: 20-40 parts of selfheal, 20-40 parts of oldenlandia diffusa, 15-35 parts of edible tulip, 10-30 parts of angelica, 10-20 parts of thunberg fritillary bulb, 5-20 parts of dandelion, 5-20 parts of spina gleditsiae, 5-15 parts of radix curcumae, 5-15 parts of semen cuscutae, 5-10 parts of curcuma zedoary, 5-10 parts of campsis grandiflora, 5-10 parts of platycodon grandiflorum, 10-20 parts of radix scrophulariae and 10-20 parts of liquorice.

2. The traditional Chinese medicine prescription preparation according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 25-35 parts of selfheal, 25-35 parts of spreading hedyotis herb, 20-30 parts of Indian iphigenia bulb, 15-25 parts of Chinese angelica, 12-18 parts of thunberg fritillary bulb, 10-15 parts of dandelion, 10-15 parts of spina gleditsiae, 8-12 parts of turmeric root-tuber, 8-12 parts of Chinese dodder seed, 6-9 parts of zedoary, 6-9 parts of Chinese trumpet creeper flower, 6-9 parts of platycodon grandiflorum, 12-18 parts of figwort root and 12-18 parts of liquorice.

3. The traditional Chinese medicine prescription preparation according to claim 2, which is characterized by comprising the following raw materials in parts by weight: 30 parts of selfheal, 30 parts of oldenlandia diffusa, 25 parts of edible tulip, 20 parts of angelica, 15 parts of thunberg fritillary bulb, 12 parts of dandelion, 12 parts of spina gleditsiae, 10 parts of radix curcumae, 10 parts of semen cuscutae, 8 parts of curcuma zedoary, 8 parts of trumpet creeper, 8 parts of platycodon grandiflorum, 15 parts of radix scrophulariae and 15 parts of liquorice.

4. The Chinese medicinal formulation according to any one of claims 1 to 3, wherein the Chinese medicinal formulation is a pill or capsule.

5. The method for preparing a Chinese medicinal formulation according to claim 4, wherein the Chinese medicinal formulation is a pill, and the method comprises the following steps:

6. The method for preparing a Chinese medicinal formulation preparation according to claim 4, wherein the Chinese medicinal formulation preparation is a capsule, and the preparation method comprises the following steps: