CN103751615B - A kind of external application of Chinese medicine agent for the treatment of acute radiation-induced esophagitis - Google Patents
A kind of external application of Chinese medicine agent for the treatment of acute radiation-induced esophagitis Download PDFInfo
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- CN103751615B CN103751615B CN201410020768.5A CN201410020768A CN103751615B CN 103751615 B CN103751615 B CN 103751615B CN 201410020768 A CN201410020768 A CN 201410020768A CN 103751615 B CN103751615 B CN 103751615B
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of external application of Chinese medicine agent for the treatment of acute radiation-induced esophagitis. Traditional Chinese medicine thinks that swallowing of radiation esophagitis choke with sobs, and the disease that diet lattice are refused is similar to the disease of ancient doctor's nationality " cancer of the esophagus ". Treat with clearing heat-fire, removing toxicity for detumescence, it is anxious that promoting blood circulation and stopping pain is controlled its mark, yin-nourishing convergence myogenic Zhi Qiben void. The present invention selects Chinese medicine lophatherum gracile, pubigerous gentian herb, coffee senna, selfheal, the Chinese bulbul, indian lettuce root, bigleaf stonecrop herb, bougainvillea, intermediate luculia root, Rhizoma Polygoni sinensis, littleleaf rourea stem and leaf, dunn antiotrema root, make externally dressing by I Drug Manufacturing Room of institute, through clinical testing, total effective rate is 96.7%, is obviously better than 70% of control group.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to one and treat acute radiation foodThe external application of Chinese medicine agent of Guan Yan.
Background technology
Thoracic malignant tumors patient is carried out in radiotherapy, reach when irradiating 1～2 weekly doseWhen 10～20Gy, can there is hyperemia, oedema in the normal esophageal mucous membrane in irradiation field, occur gulping downPharynx difficulty; When exposure dose reaches after 30～40Gy, mucous membrane of esophagus hyperemia further increases the weight of,Show as burn feeling after local pain or breastbone, severe one endurable, during especially taking feed as outstanding,The clinical radiation esophagitis that is referred to as. For the treatment of radioactive damage, all in all doctor trained in Western medicine is controlledTreatment means fail to depart from antibiotic, Metabolism, Vitamins and Hormones " three elements " category. At administering modeThe upper form that adopts oral or atomization more. Though these class methods can effectively be alleviated partial symptoms, itsSide effect is also comparatively obvious, as immunologic function suppress, increase the weight of or bring out infection, flora imbalance,After hemorrhage of digestive tract, drug withdrawal, bounce etc., and late result is not good enough. The traditional Chinese medical science is eaten at radiotherapyManage scorching aspect and also carried out a large amount of explorations, and accumulated good experience. The traditional Chinese medical science, Chinese medicine riseArrive comprehensive opsonic action, its not only can easing oesophagus scorching pain itself, and can be notWith degree treat other radiation complication, regulate the integrality of body, have and exempt from simultaneouslyThe function that epidemic disease regulates. Acupuncture points external application agent is applicable to prevent and treat radiation esophagitis, in therapeutic process, suffers fromPerson reacts without discomfort, and without contraindication, the early stage analgesic effect of medication is obvious, and patient is easy to accept.
Summary of the invention
The object of this invention is to provide a kind of external application of Chinese medicine for the treatment of acute radiation-induced esophagitisAgent. Traditional Chinese medicine thinks that swallowing of radiation esophagitis choke with sobs, and the disease that diet lattice are refused is similar to GuThe disease of doctor's nationality " cancer of the esophagus ". Treat with clearing heat-fire, removing toxicity for detumescence, promoting blood circulation and stopping pain is controlled its markAnxious, yin-nourishing convergence myogenic Zhi Qiben void.
The object of the invention is to be achieved through the following technical solutions this treatment acute radiationThe external application of Chinese medicine agent of esophagitis is made up of the Chinese medicine of following weight portion: lophatherum gracile 10-14 part,Pubigerous gentian herb 9-15 part, coffee senna 6-9 part, selfheal 5-15 part, Chinese bulbul 9-15 part,Indian lettuce root 15-30 part, bigleaf stonecrop herb 25-32 part, bougainvillea 9-15 part, intermediate luculia root20-25 part, Rhizoma Polygoni sinensis 3-9 part, littleleaf rourea stem and leaf 7-10 part, dunn antiotrema root 9-15 part.
Preferred: 12 parts of lophatherum graciles, 12 parts of pubigerous gentian herbs, 8 parts of coffee sennas, selfheal10 parts, 12 parts of the Chinese bulbuls, 20 parts of indian lettuce roots, 28 parts of bigleaf stonecrop herbs, bougainvillea 12Part, 23 parts of intermediate luculia roots, 6 parts of Rhizoma Polygoni sinensis, 8.5 parts of littleleaf rourea stem and leafs, 12 parts of dunn antiotrema roots.
Preparation method is by for subsequent use above-mentioned Chinese medicine pulverization.
Fang Zhong: lophatherum gracile heat-clearing is except fire; Pubigerous gentian herb heat-clearing and fire-reducing; Coffee senna clearing liver removing toxic substances;Selfheal clearing liver dissipating bind; The Chinese bulbul is clearing heat and detoxicating; Indian lettuce root, bigleaf stonecrop herb removing toxicity for detumescence,Bougainvillea, intermediate luculia root promoting blood circulation and stopping pain; Rhizoma Polygoni sinensis, littleleaf rourea stem and leaf convergence myogenic, dunn antiotrema root are supportedCloudy qi-restoratives;
Clinical data
1. the routine patient of physical data 60 is the court's radiotherapy department and accepts the trouble of radiotherapy to the chestPerson, the wherein cancer of the esophagus 39 examples, lung cancer 21 examples, are all acute radiation oesophagus through clinical diagnosisInflammation, is divided into treatment group and control group. Two groups all adopt three dimensional conformal radiation therapy or intensity modulated radiation therapy.Treatment group 30 examples, male 18 examples, female's 12 examples, 58.5 years old mean age, radiotherapy accumulated dose58～65Gy, length of esophagus 5～15cm in irradiation field, the cancer of the esophagus 20 examples, lung cancer 10 examples;Control group 30 examples, male 20 examples, female's 10 examples, 59.6 years old mean age, radiotherapy accumulated dose58～64Gy, length of esophagus 5～13cm in irradiation field, the cancer of the esophagus 19 examples, lung cancer 11 examples;The clinical factors such as two groups of patient ages, sex, histological type are analyzed not statistically significant (P> 0.05), there is comparativity.
2. diagnostic criteria (1) has breast tumor radiotherapy history or is carrying out radiotherapy.(2) clinical manifestation: mediastinal tumor, the non-oesophagus disease such as lung cancer occurs in Patients During RadiotherapyWith the retrosternal pain of primary disease without direct relation, feed burn feeling, swallows discomfort, tightThere is feed pain in severe one, thereby fears feed. Above-mentioned except occurring in radiotherapy in esophageal carcinoma patientsOutside symptom, feed difficulty obviously increases the weight of before treating. Have a medical check-up general without obvious sign. (3)Esophagogram shows mucous membrane disorder, blocks and increases the weight of, and tube chamber is less. The visible exposure of endoscopyEsophageal Mucosa hyperemia, oedema, even pseudomembrane forms.
3. methods for the treatment of treatment group patient adopts the treatment of acupuncture points external application method, takes lophatherum gracile12g, pubigerous gentian herb 12g, coffee senna 8g, selfheal 10g, Chinese bulbul 12g, indian lettuce root20g, bigleaf stonecrop herb 28g, bougainvillea 12g, intermediate luculia root 23g, Rhizoma Polygoni sinensis 6g, litchiBranch rattan 8.5g, dunn antiotrema root 12g, smash above-mentioned Chinese medicine to pieces pulverization, reconciles into honeyPaste is for subsequent use. Be applied in equably with spatula on the sterile gauze of 3 bed thickness and make emplastrum,Thickness is 1～2mm approximately, then emplastrum is spread on to the medium acupuncture point of Zusanli, Tiantu and wingceltis, properlyFixing, change every day 1 time; Conventional application physiological saline, carbon when control group radiation treatmentThe GARG that acid hydrogen sodium, lidocaine are made into is gargled to patient or contains clothes.
4. criterion of therapeutical effect is effective: swallow pain and dysphagia disappears substantially; Effective: to gulp downPharynx pain and (or) dysphagia obviously alleviate; Invalid: to swallow pain and dysphagia slightlyHave and alleviate or without improvement.
5. two groups of patients of result for the treatment of treat observe the curative effect after 10 days, treatment group 30 continuouslyIn example, wherein effective 20 examples (66.7%), effective 9 examples (30%), invalid 1 example (3.3%),Total effective rate is 96.7%; In control group 30 examples, wherein effective 10 examples (33.3%), effectively11 examples (36.7%), no effect 9 (30%), total effective rate is 70%. Two groups of total effective ratesComparing difference has significant (P < 0.05), and treatment group result for the treatment of is obviously better than contrastGroup.
Detailed description of the invention
Embodiment mono-: take lophatherum gracile 12g, pubigerous gentian herb 12g, coffee senna 8g, selfheal10g, Chinese bulbul 12g, indian lettuce root 20g, bigleaf stonecrop herb 28g, bougainvillea 12g, wild fourthCus-cus 23g, Rhizoma Polygoni sinensis 6g, littleleaf rourea stem and leaf 8.5g, dunn antiotrema root 12g, be ground into above-mentioned Chinese medicineSmalls is for subsequent use.
Embodiment bis-: take lophatherum gracile 10g, pubigerous gentian herb 15g, coffee senna 6g, selfheal15g, Chinese bulbul 9g, indian lettuce root 30g, bigleaf stonecrop herb 25g, bougainvillea 15g, wild fourthCus-cus 20g, Rhizoma Polygoni sinensis 9g, littleleaf rourea stem and leaf 10g, dunn antiotrema root 15g, be ground into above-mentioned Chinese medicine carefullyEnd is for subsequent use.
Embodiment tri-: take lophatherum gracile 14g, pubigerous gentian herb 9g, coffee senna 9g, selfheal5g, Chinese bulbul 15g, indian lettuce root 15g, bigleaf stonecrop herb 32g, bougainvillea 9g, wild clovesRoot 25g, Rhizoma Polygoni sinensis 3g, littleleaf rourea stem and leaf 7g, dunn antiotrema root 9g, by standby above-mentioned Chinese medicine pulverizationWith.
Claims (2)
1. a Chinese traditional medicine point plaster agent for the treatment of acute radiation-induced esophagitis, is characterized in thatThis Chinese traditional medicine point plaster agent is made up of the Chinese medicine of following weight portion: lophatherum gracile 10-14 part, shortPin rough gentian 9-15 part, coffee senna 6-9 part, selfheal 5-15 part, Chinese bulbul 9-15 part,Indian lettuce root 15-30 part, bigleaf stonecrop herb 25-32 part, bougainvillea 9-15 part, intermediate luculia root20-25 part, Rhizoma Polygoni sinensis 3-9 part, littleleaf rourea stem and leaf 7-10 part, dunn antiotrema root 9-15 part.
2. a kind of Chinese medicine cave for the treatment of acute radiation-induced esophagitis according to claim 1Position externally dressing, is characterized in that this Chinese traditional medicine point plaster agent is made up of the Chinese medicine of following weight portion:12 parts of lophatherum graciles, 12 parts of pubigerous gentian herbs, 8 parts of coffee sennas, 10 parts of selfheals, the Chinese bulbul12 parts, 20 parts of indian lettuce roots, 28 parts of bigleaf stonecrop herbs, 12 parts of bougainvilleas, intermediate luculia root23 parts, 6 parts of Rhizoma Polygoni sinensis, 8.5 parts of littleleaf rourea stem and leafs, 12 parts of dunn antiotrema roots.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101259216A (en) * | 2008-04-21 | 2008-09-10 | 北京中科仁和科技有限公司 | Chinese medicinal composition for treating nodus lymphaticus and preparation thereof |
| CN101843882A (en) * | 2009-11-05 | 2010-09-29 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating cholecystitis diseases and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101259216A (en) * | 2008-04-21 | 2008-09-10 | 北京中科仁和科技有限公司 | Chinese medicinal composition for treating nodus lymphaticus and preparation thereof |
| CN101843882A (en) * | 2009-11-05 | 2010-09-29 | 泰一和浦（北京）中医药研究院有限公司 | Chinese medicinal composition for treating cholecystitis diseases and preparation method thereof |
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