CN101584802B

CN101584802B - Chinese medicinal capsule for treating malignant lymphoma

Info

Publication number: CN101584802B
Application number: CN2009100158921A
Authority: CN
Inventors: 李宗宪; 刘秀萍; 吕清华
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-06-17
Filing date: 2009-06-17
Publication date: 2011-06-08
Anticipated expiration: 2029-06-17
Also published as: CN101584802A

Abstract

The invention relates to the field of medicament formulation, in particular to a Chinese medicinal capsule for treating malignant lymphoma. Pinellia tuber, tangerine peel, radix ranunculi ternati, self-heal, mustard seed, wall lizard, polyporus umbellatus, fritillaria and oyster are used as raw materials; and the raw materials are cleaned, dried and ultramicro-crushed to reach the fineness of 400 meshes, the crushed raw materials are prepared into powder, and the powder is filled into capsules. The Chinese medicinal capsule is characterized in that the following raw materials by weight portion: 3 to 9 portions of the pinellia tuber, 3 to 9 portions of the tangerine peel, 9 to 15 portions of the radix ranunculi ternati, 9 to 15 portions of the self-heal, 3 to 9 portions of the mustard seed,1.5 to 4.5 portions of the wall lizard, 6 to 18 portions of the polyporus umbellatus, 3 to 6 portions of the fritillaria and 15 to 30 portions of the oyster. The Chinese medicinal capsule has the rem arkable efficacies of softening hardness and dissipating binds, reducing phlegm and resolving toxin, soothing liver and strengthening stomach, and supporting right qi, has no obvious toxic and side effect after a patient takes the capsule, is applicable to the treatment of the malignant lymphoma, and has high clinical yield.

Description

A kind of Chinese medicinal capsule for the treatment of malignant lymphoma

Technical field

The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of Chinese medicinal capsule for the treatment of malignant lymphoma.

Background technology

As everyone knows, malignant tumor has the trend of increasing in worldwide, and the sickness rate of China's malignant tumor also increases year by year.Malignant lymphoma accounts for 4.1% of malignant tumor total incidence, is to derive from the lymphoreticular tissue malignant tumor in close relations with immunity, mainly betides lymph node, also can betide outside lymph node and non-lymphoid tissue.Be divided into Hodgkin and non-Hodgkin lymphoma, mainly show as the lymphadenectasis of painless carrying out property of property, heating, night sweat, disease such as weak.According to the difference of site of pathological change and different histological type, other corresponding clinical manifestation can be arranged also.The diagnosis of malignant lymphoma is goldstandard with the pathological diagnosis.

The western medical treatment malignant lymphoma has therapeutic schemes such as radiotherapy, chemotherapy, Biotherapeutics at present, though obtained better curative effect, then can cause the decline of serious adverse and immune function for a big chunk patient.

Summary of the invention

Purpose of the present invention is exactly in order to overcome above-mentioned existing technical deficiency, a kind of Chinese medicinal capsule for the treatment of malignant lymphoma is provided, have hard masses softening and resolving, the remarkable efficacy of the detoxifcation of reducing phlegm, relaxing liver and strengthening stomach, reinforcing body resistance, after the patient takes, there is not obvious toxic-side effects, be applicable to the treatment of malignant lymphoma, clinical yield is higher.

The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of Chinese medicinal capsule for the treatment of malignant lymphoma, adopting the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Radix Ranunculi Ternati, Spica Prunellae, Semen Sinapis Albae, Gekko Swinhonis, Polyporus, Bulbus Fritillariae Uninbracteatae, Concha Ostreae is raw material, raw material is cleaned oven dry carry out micronizing, fineness reaches 400 orders, make powder and inject capsule, the weight portion that it is characterized in that raw material is: Rhizoma Pinelliae 3-9 part, Pericarpium Citri Reticulatae 3-9 part, Radix Ranunculi Ternati 9-15 part, Spica Prunellae 9-15 part, Semen Sinapis Albae 3-9 part, Gekko Swinhonis 1.5-4.5 part, Polyporus 6-18 part, Bulbus Fritillariae Uninbracteatae 3-6 part, Concha Ostreae 15-30 part.

The weight portion preferable range of raw material of the present invention is: 6 parts of the Rhizoma Pinelliaes, 6 parts of Pericarpium Citri Reticulataes, 12 parts of Radix Ranunculi Ternatis, 12 parts of Spica Prunellaes, 6 parts of Semen Sinapis Albaes, 3 parts of Gekko Swinhonis, 12 parts of Polyporus, 4 parts of Bulbus Fritillariae Uninbracteataes, 20 parts of Concha Ostreaes.

The present invention is used for the treatment of the Chinese medicinal capsule of malignant lymphoma, has hard masses softening and resolving, a remarkable efficacy of the detoxifcation of reducing phlegm, relaxing liver and strengthening stomach, reinforcing body resistance, after the patient takes, does not have obvious toxic-side effects, is applicable to the treatment of malignant lymphoma, and clinical yield is higher.

The specific embodiment

The invention will be further described below in conjunction with embodiment:

Embodiment 1:

Present embodiment uses the following raw materials in weight medicine to make, the Rhizoma Pinelliae 60 grams, Pericarpium Citri Reticulatae 60 grams, Radix Ranunculi Ternati 120 grams, Spica Prunellae 120 grams, Semen Sinapis Albae 60 grams, Gekko Swinhonis 30 grams, Polyporus 120 grams, Bulbus Fritillariae Uninbracteatae 40 grams, Concha Ostreae 200 grams are cleaned oven dry with the above-mentioned raw materials medicine and are carried out micronizing, and fineness reaches 400 orders, make powder and inject capsule, the powder explosive payload of every capsules is 1 gram, takes 5 capsules at every turn, every day secondary, early, take evening.One month is a course of treatment, and curative effect is estimated in logotype two courses of treatment.

The present invention selects for use the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Radix Ranunculi Ternati, Spica Prunellae, Semen Sinapis Albae, Gekko Swinhonis, Polyporus, Bulbus Fritillariae Uninbracteatae, Concha Ostreae to make up, and makes each efficacy of drugs produce synergism after the combination, thereby can treat malignant lymphoma effectively.Wherein Rhizoma Pinelliae acrid in the mouth is warm in nature, and is poisonous.Return spleen, stomach, lung meridian.Effect with drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Pericarpium Citri Reticulatae acrid in the mouth, hardship, warm in nature.Return spleen, lung meridian.Have that circulation of qi promoting is good for the stomach, the effect of drying dampness to eliminate phlegm.Radix Ranunculi Ternati acrid in the mouth, hardship, property is flat.Slightly poisonous.Return liver, lung meridian.Effect with hard masses softening and resolving, detoxifcation.Spica Prunellae bitter in the mouth, suffering, cold in nature.Return Liver Channel.Has clearing away liver-fire, the effect of Disperse hepatic depression.The Semen Sinapis Albae acrid in the mouth, warm in nature.Return lung meridian.Has warming for resolving cold-phlegm, the effect of mass dissipating and swelling eliminating.The Gekko Swinhonis salty in the mouth, cold in nature.Slightly poisonous.Return lung, kidney channel.Have and dispel the wind, active, the effect of eliminating stagnation.Polyporus sweet in the mouth, light, property is flat.Return kidney, urinary bladder channel.Effect with promoting diuresis to eliminate damp pathogen.Bulbus Fritillariae Uninbracteatae bitter in the mouth, sweet, cold nature.Return lung meridian.Has moistening the lung and resolving phlegm, the effect of heat clearing away eliminating stagnation.Concha Ostreae salty in the mouth, puckery, cold nature.Return liver, kidney channel.Have suppressing the hyperactive liver and subsiding YANG, hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating effect.All medicine compatibilities are played hard masses softening and resolving, the effect of the detoxifcation of reducing phlegm, relaxing liver and strengthening stomach, reinforcing body resistance altogether.Modern pharmacological research: the Rhizoma Pinelliae all can be by the pinellin coagulation to mouse boosting cell, human liver cancer cell (QGY7703-3 and 7402), ehrlich carcinoma and ascites hepatoma cells, and short cell division effect is arranged.The contained volatile oil of Pericarpium Citri Reticulatae has gentle stimulation to gastrointestinal tract, but the secretion of facilitating digestion liquid is got rid of pneumatosis in the intestinal tube, stimulating appetite; Also has the zest phlegm-dispelling functions.Radix Ranunculi Ternati contains organic acid, saccharide, aminoacid etc.Radix Ranunculi Ternati has certain antitumor action, and zoopery confirms that this product all has inhibitory action to mice S180, S37, ehrlich carcinoma.The Spica Prunellae decoct can suppress the growth of mice S-180 tumor and ehrlich carcinoma.Semen Sinapis Albae contains Sinapine glucosinalbate., myrosase, sinapic acid choline ester. and fatty oil.Sinapine glucosinalbate. produces volatility Caulis et Folium Sinapis albee oil, sinapine bisulfate and glucose through enzyme hydrolysis, shows the antineoplastic therapeutical effect in vivo.The Gekko Swinhonis in vitro tests shows that its aqueous solution has obvious inhibitory action to the breathing of human hepatoma cell; And contain abundant vitaminF, proved that vitaminF has certain active anticancer.The main effective ingredient that extracts in the Polyporus is a polyporusum bellatus, and its effect has: 1. immunological enhancement.2. the plain effect of a kind of non-T cell mitogenesis.3. antitumor action.Polyporusum bellatus has than significant inhibitory effect mice transplanted tumor S-180, inhibitory rate 50-70%, and the heavy suppression ratio of tumor reaches more than 30%.4. experimental tumor of bladder there is inhibitory action.5. the radiation resistance of polyporusum bellatus may be by regulating the function of hypophysis-adrenal system, making body be in stress state, thereby strengthened the ability of Antiradiation injury.Bulbus Fritillariae Uninbracteatae has antitumor action, and its antineoplastic component is E Beiding alkali, peimine and verticinone.Concha Ostreae contains calcium carbonate, calcium phosphate and calcium sulfate.And trace element and several amino acids such as cupric, ferrum, zinc, manganese, strontium, chromium.Convergence, calmness, detoxifcation, analgesic effect are arranged, can human body immunity improving power.

Embodiment 2:

Present embodiment uses the following raw materials in weight medicine to make, the Rhizoma Pinelliae 80 grams, Pericarpium Citri Reticulatae 40 grams, Radix Ranunculi Ternati 100 grams, Spica Prunellae 100 grams, Semen Sinapis Albae 80 grams, Gekko Swinhonis 30 grams, Polyporus 150 grams, Bulbus Fritillariae Uninbracteatae 50 grams, Concha Ostreae 250 grams are cleaned oven dry with the above-mentioned raw materials medicine and are carried out micronizing, and fineness reaches 400 orders, make powder and inject capsule, the powder explosive payload of every capsules is 1 gram, takes 5 capsules at every turn, every day secondary, early, take evening.One month is a course of treatment, and curative effect is estimated in logotype two courses of treatment.

But each raw material of the present invention also embodiment of the listed mixed of according to the form below is realized.Its processing is identical with embodiment 1.(unit: gram)

Embodiment	The Rhizoma Pinelliae	Pericarpium Citri Reticulatae	Radix Ranunculi Ternati	Spica Prunellae	Semen Sinapis Albae	Gekko Swinhonis	Polyporus	Bulbus Fritillariae Uninbracteatae	Concha Ostreae
										3	30	90	90	150	90	45	60	60	150
4	90	30	150	90	30	15	180	30	300

5	40	70	120	100	60	35	150	50	260
										6	80	50	140	130	70	20	80	40	200

1, clinical data: clinically select 32 routine patients at random, male's 18 examples wherein, women's 14 examples.All patients all make a definite diagnosis through histopathology.

2, Therapeutic Method: medicine of the present invention is pressed the preferred proportion prescription, adopt Chinese medicine to make common process and make powder, inject capsule.5 of each clothes (every contains powder 1 gram), every day secondary, early, take evening.One month is a course of treatment, and curative effect is estimated in logotype two courses of treatment.

3, curative effect is judged:

Alleviate fully (CR): visible neoplastic lesion complete obiteration, keep more than 4 weeks.

Part is alleviated (PR): the product of the vertical transverse diameter of the maximum gauge of tumor focus and maximum thereof dwindles more than 50%, and other focuses do not have increase, does not have new focus and occurs, and keeps more than 4 weeks.

Stable (SD): two footpath products of tumor focus dwindle less than 50%, or increase and be no more than 25%, do not have new focus and occur, and keep more than 4 weeks.

Progress (PD): two footpath products of tumor focus increase more than 25% or new focus occurs.

4, therapeutic effect: use the present invention to treat 32 examples, the result: CR 11 examples (34.4%), PR 15 examples (46.9%), SD 2 examples (6.2%), PD 4 examples (12.5%), clinical yield is (CR+PR+SD) 87.5%.

Claims

1. Chinese medicinal capsule for the treatment of malignant lymphoma, adopting the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Radix Ranunculi Ternati, Spica Prunellae, Semen Sinapis Albae, Gekko Swinhonis, Polyporus, Bulbus Fritillariae Uninbracteatae, Concha Ostreae is raw material, raw material is cleaned oven dry carry out micronizing, fineness reaches 400 orders, makes powder and injects capsule, it is characterized in that the weight portion of raw material is: Rhizoma Pinelliae 3-9 part, Pericarpium Citri Reticulatae 3-9 part, Radix Ranunculi Ternati 9-15 part, Spica Prunellae 9-15 part, Semen Sinapis Albae 3-9 part, Gekko Swinhonis 1.5-4.5 part, Polyporus 6-18 part, Bulbus Fritillariae Uninbracteatae 3-6 part, Concha Ostreae 15-30 part.

2. Chinese medicinal capsule for the treatment of malignant lymphoma, adopting the Rhizoma Pinelliae, Pericarpium Citri Reticulatae, Radix Ranunculi Ternati, Spica Prunellae, Semen Sinapis Albae, Gekko Swinhonis, Polyporus, Bulbus Fritillariae Uninbracteatae, Concha Ostreae is raw material, raw material is cleaned oven dry carry out micronizing, fineness reaches 400 orders, makes powder and injects capsule, it is characterized in that the weight portion of said raw material is, 6 parts of the Rhizoma Pinelliaes, 6 parts of Pericarpium Citri Reticulataes, 12 parts of Radix Ranunculi Ternatis, 12 parts of Spica Prunellaes, 6 parts of Semen Sinapis Albaes, 3 parts of Gekko Swinhonis, 12 parts of Polyporus, 4 parts of Bulbus Fritillariae Uninbracteataes, 20 parts of Concha Ostreaes.