CN106063810A - A kind of Chinese medicine preparation treating chronic ulcerative colitis - Google Patents
A kind of Chinese medicine preparation treating chronic ulcerative colitis Download PDFInfo
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- CN106063810A CN106063810A CN201610643119.XA CN201610643119A CN106063810A CN 106063810 A CN106063810 A CN 106063810A CN 201610643119 A CN201610643119 A CN 201610643119A CN 106063810 A CN106063810 A CN 106063810A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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Abstract
The invention discloses a kind of Chinese medicine preparation treating chronic ulcerative colitis, belong to technical field of Chinese medicines.The cause of disease that inventor occurs for chronic ulcerative colitis, according to the Chinese traditional treatment principle of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, selecting Chinese medicine Herba Sebi drymarioidis, Stachys palustris L., Radix seu caulis viburni tomentosi, Herba Laggerae Alatae, Radix Phyllanthi cochinchinensis, Herba Stellariae Neglectae, decocting becomes decoction, through clinical trial, total effective rate reaches 97.5%.Clinical trial proves, this Chinese medicine preparation also has preferable therapeutic effect to night sweat.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly relate to a kind of Chinese medicine preparation treating chronic ulcerative colitis.
Background technology
Ulcerative colitis, also known as nonspecific ulcerative colitis, is first described as being different from carefully for 1859 by Wilks
The independent colitis disease of bacterium property dysentery, is a kind of cause of disease chronic disease the most fully aware of.Cardinal symptom has abdomen
Rush down, bloody purulent stool, stomachache etc..Diseased region is mainly at rectum, sigmoid colon, it is possible to involve descending colon and whole colon.In activity
Phase mainly shows as the nonspecific inflammation of intestinal mucosa and distinctive ulcer, and it is non-specific that the catabasis mainly shows as intestinal mucosa
The inflammation of property.This disease pathological changes recurrent exerbation, the course of disease is touching, and delay difficulty is more.Doctor trained in Western medicine is for a long time mainly by hormone, anti-infective
Thing and immunosuppressant etc. are treated, and for serious symptom or there is complication patient, general use colostomy or total colectomy to cut
Except art.These Therapeutic Method are not ideal enough, and side effect is big, and relapse rate is high.Inventor, in clinical practice for many years, applies
Chinese medicine, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, achieve preferable curative effect.
Summary of the invention
It is an object of the invention to provide a kind of Chinese medicine preparation treating chronic ulcerative colitis.Motherland's medical science thinks primary disease
Be due to eating and drinking without temperance, disorder of emotion, being invaded by exogenous pathogen, overstrain, prolonged illness etc. after, cause temper impaired, spleen loses strong
Fortune, the defeated cloth of essence of water and grain is unfavorable, clear QI being mixed up with turbid QI, bets and falls ill in intestinal.
It is an object of the invention to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment chronic ulcerative colitis
It is made up of the Chinese medicine of following weight portion: Herba Sebi drymarioidis 15-21 part, Stachys palustris L. 15-25 part, Radix seu caulis viburni tomentosi 6-10 part, Herba Laggerae Alatae
8-14 part, Radix Phyllanthi cochinchinensis 6-10 part, Herba Stellariae Neglectae 12-18 part.
Preferred: Herba Sebi drymarioidis 18 parts, Stachys palustris L. 20 parts, Radix seu caulis viburni tomentosi 8 parts, Herba Laggerae Alatae 11 parts, Radix Phyllanthi cochinchinensis 8 parts, chicken
Intestines and stomach grass 15 parts.
Preparation method: traditionally make decoction.
Fang Zhong: Herba Sebi drymarioidis clearing away heat and cooling blood, subduing swelling and detoxicating；Stachys palustris L. removing heat-phlegm, anti-inflammation, tonifying YIN relieve inflammation or internal heat；
Radix seu caulis viburni tomentosi heat-clearing and toxic substances removing, spleen invigorating removing food stagnancy；Herba Laggerae Alatae expelling wind and removing dampness, change stagnant dissipating blood stasis, subduing swelling and detoxicating；Radix Phyllanthi cochinchinensis clearing away damp-heat, removing toxic substances disappear
Long-pending；Herba Stellariae Neglectae anti-inflammation.
Detailed description of the invention
Embodiment one: weigh Herba Sebi drymarioidis 15g, Stachys palustris L. 15g, Radix seu caulis viburni tomentosi 6g, Herba Laggerae Alatae 8g, Radix Phyllanthi cochinchinensis 6g,
Herba Stellariae Neglectae 12g, traditionally makes decoction.
Embodiment two: weigh Herba Sebi drymarioidis 18g, Stachys palustris L. 20g, Radix seu caulis viburni tomentosi 8g, Herba Laggerae Alatae 11g, Radix Phyllanthi cochinchinensis 8g,
Herba Stellariae Neglectae 15g, traditionally makes decoction.
Embodiment three: weigh Herba Sebi drymarioidis 21g, Stachys palustris L. 25g, Radix seu caulis viburni tomentosi 10g, Herba Laggerae Alatae 14g, Radix Phyllanthi cochinchinensis
10g, Herba Stellariae Neglectae 18g, traditionally make decoction.
Toxicity test
1, laboratory animal cleaning grade healthy SD female rats 40, weight (190 ± 8) g, as chronic toxicity；
The female white mice in cleaning grade health Kunming 30, weight (26 ± 3) g, as acute toxicological experiment.Feed with normal diet, general
Logical drinking-water.Room temperature controls in (23 ± 3) DEG C, humidity (50 ± 4) %, natural lighting.
2, acute toxicological experiment is according to (Chinese medicine, researches on natural drugs registration service manual), selects cleaning grade health Kunming
Female white mice 30, is randomly divided into 2 groups, Chinese drug-treated group and each 15 of blank group.Chinese drug-treated group is administered orally 6g/d by adult normal
(being equivalent to crude drug 80g) is converted to the dosage of white mice, gavages Chinese medicine every day 1 time.Blank group gives 1mL/20g weight
0.9% sodium chloride injection gavages.
3, long term toxicity test cleaning grade healthy SD female rats 40, is randomly divided into 4 groups, Normal group and Chinese medicine
Group little, in, heavy dose of each 10.Matched group gives 1ml/20g weight 0.9% sodium chloride injection, Chinese drug-treated group little, in,
Heavy dose of group is that adult normal consumption is converted to the 5 of rat dosage, 15,50 times, i.e. 0.15g, 0.45g, 1.5g.Be gavage to
Medicine.Every day 1 time, experimental period is 3 months.
4, acute toxicity testing result white mice nothing in being administered 7d is dead, to observation post administration mice outward appearance, hair color, light
Pool is normal, and social behavior, reaction are all normal, ingests, drains normally.Manually put to death dissection after 7d, observe its heart, liver, spleen
Dirty, lungs, kidney, brain, ovary, uterus are showed no exception.Pathological examination: dyeing in single-minded Yihong of Lignum Sappan (HE), Chinese drug-treated group is dirty
Device smooth surface, in order, cell size, form are normal in organizational structure arrangement, and the dyeing of endochylema, karyon is clear, with blank group
Comparing difference not statistically significant (P ＞ 0.05).
5, chronic toxicity result Chinese drug-treated group little, in, heavy dose of group and the outward appearance of rats in normal control group, hair color,
Social behavior, zest etc. and to surrounding, food, the equal not statistically significant of comparing difference (P ＞ 0.05) such as interest of water.
(P ＜ 0.05) is increased before the experiment of weight the most relatively this group after 4 groups of rat experiments, but the equal nothing of weight comparing difference after 4 groups of experiments
Statistical significance (P ＞ 0.05), blood cytology index, blood biochemical analysis index, important organ coefficient ratio after 4 groups of rat experiments
Compared with the equal not statistically significant of difference (P ＞ 0.05).At 4 groups of rats, after death important organ row staining pathologic section checks, HE dyes.
In order, cell size, form are normal for the arrangement of Chinese drug-treated group Rats Organs and Tissues organizational structure, and the dyeing of endochylema, karyon is clear, with normal control
Group comparing difference not statistically significant (P ＞ 0.05).
Toxicity test shows, the Chinese medicine preparation of the treatment chronic ulcerative colitis of the present invention
Toxic reaction is had no after administration.
Clinical data
1, this group of physical data case is this Out-patient Department and inpatient 200 example, the maleest 100 examples, female 100 example；Year
Age 19～54 years old, the course of disease 5～39 months, average 20 ± 1.6 months；On the basis of patient knows the inside story and be voluntary, patient is divided by we
It it is 8 groups；Only take Herba Sebi drymarioidis single medicinal material group to be A group, only take Stachys palustris L. single medicinal material group and be B group, only take Radix seu caulis viburni tomentosi
Single medicinal material group is C group, only take Herba Laggerae Alatae single medicinal material group is D group, only takes Radix Phyllanthi cochinchinensis single medicinal material group and be E group, only take chicken tripe
Intestinal grass single medicinal material group is F group, and taking the present invention by embodiment two preparation group is treatment group, and employing routine treatment is matched group.
Each group is compared not statistically significant (P ＞ 0.05) in the physical data such as age, sex, has comparability.
2, diagnostic criteria (1) Western medicine diagnose standard: with reference to the whole nation, Taiyuan in 1993 " chronic noninfective intestinal tract disease
Art seminar " standard.(2) tcm diagnosis standard: with reference to " new Chinese medicine guideline of clinical investigations " (2002 May the 1st edition).
3, Therapeutic Method treatment group takes the Chinese medicine preparation made by embodiment of the present invention two, and each single medicinal material group is taken
With treatment group same concentrations same amount of single medicinal material preparation, each group every day 1 dose be 400ml, divides and takes for 2 times.Matched group therapy: mouth
Take SASP, 2 pieces/times, 2 times/d.Two groups equal 2 weeks is 1 course for the treatment of, and each group is with adding up curative effect after two courses for the treatment of.
4, criterion of therapeutical effect is cured: clinical symptoms, sign are wholly absent, and checks that colonic mucosa pathological changes is recovered normal or leaves over
Cicatrix；Effective: clinical symptoms, sign disappear substantially, check that colonic mucosa pathological changes has alleviated；Invalid: clinical symptoms, sign without
Improve, check that colonic mucosa pathological changes is unchanged or increases the weight of.
5, each group of efficacy result is taken medicine after two courses for the treatment of, comparative result.
The therapeutic effect of Chinese medicine preparation of the present invention treatment chronic ulcerative colitis is respectively organized far better than other
Therapeutic effect；The total effective rate for the treatment of group is apparently higher than each single medicinal material group total effective rate sum；It follows that the treatment for the treatment of group
Effect is the mutual synergistic result of each single medicinal material.
Model case
Liu, man, 36 years old.Patient suffered from more than abdominal pain diarrhea companion's bloody purulent stool, mucus just symptom half a year.Local hospital is diagnosed as
Enteritis, has used a lot of anti-inflammation drugs, although having effect during medication, but easily recur after drug withdrawal, even increase the weight of, treatment has no
Through large hospital sigmoidoscopy, positive effect, before half a year, finds that 16-18 centimeters is congested, rotten to the corn, has petechia, then examine
Break as chronic ulcerative colitis.Use Chinese medicine preparation of the present invention treatment 1 course for the treatment of after all diseases subtract greatly, stool shape, only after
Section is the dilutest.Patient is full of confidence, continues to take 1 course for the treatment of, patient clinical transference cure, and the mental status recovers normal, hospital's mirror
Fully recover without petechia, ulcer healing, patient in inspection check display affected part.Follow up a case by regular visits to have no recurrence half a year.
When above patient is followed up a case by regular visits to, wherein have 3 example readmes " after taking the preparation of the present invention, not only chronic ulcer
Property colitis obtained rehabilitation, and night sweat symptom might as well ".After obtaining this message, we suffer from difference to 40 examples immediately
Degree night sweat patient, uses the Chinese medicine preparation that embodiment of the present invention two prepares, and every day, potion, divided the method sooner or later taken for twice
Treated.Curative effect judging standard is fully recovered: night sweat stops completely, and concomitant symptom disappears substantially, nothing recurrence in 1 year after drug withdrawal；Effective:
Night sweat stops substantially, and concomitant symptom has been alleviated, nothing recurrence in 6 months after drug withdrawal；Invalid: night sweat and concomitant symptom are all without improving.
Result: in 40 example patients, 24 examples of fully recovering (60%), effective 14 examples (35%), invalid 2 examples (5%), total effective rate is by recovery from illness and shows
Effect meter, is 95%.It follows that take the Chinese medicine preparation of the present invention, not only treatment chronic ulcerative colitis is evident in efficacy, and
And night sweat is had good therapeutic effect, clinic popularization and application.
Claims (2)
1. the Chinese medicine preparation treating chronic ulcerative colitis, it is characterised in that this Chinese medicine preparation is by following weight portion
Medicine is made: Herba Sebi drymarioidis 15-21 part, Stachys palustris L. 15-25 part, Radix seu caulis viburni tomentosi 6-10 part, Herba Laggerae Alatae 8-14 part, Radix Phyllanthi cochinchinensis 6-10
Part, Herba Stellariae Neglectae 12-18 part.
A kind of Chinese medicine preparation treating chronic ulcerative colitis, it is characterised in that this Chinese medicine system
Agent is made up of the Chinese medicine of following weight portion: Herba Sebi drymarioidis 18 parts, Stachys palustris L. 20 parts, Radix seu caulis viburni tomentosi 8 parts, Herba Laggerae Alatae 11 parts, Canis familiaris L.
Footprint 8 parts, Herba Stellariae Neglectae 15 parts.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610643119.XA CN106063810A (en) | 2016-07-30 | 2016-07-30 | A kind of Chinese medicine preparation treating chronic ulcerative colitis |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201610643119.XA CN106063810A (en) | 2016-07-30 | 2016-07-30 | A kind of Chinese medicine preparation treating chronic ulcerative colitis |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103656319A (en) * | 2013-12-15 | 2014-03-26 | 高继绪 | Application for treating acute radiation-induced esophagitis |
| CN103845391A (en) * | 2012-12-06 | 2014-06-11 | 鲜丹科 | Weichangrexuezhi |
| CN104958645A (en) * | 2015-07-25 | 2015-10-07 | 王璐 | Traditional Chinese medicine for treating gastric ulcer |
| CN105343734A (en) * | 2015-11-29 | 2016-02-24 | 马良 | Traditional Chinese medicine for treating spleen and stomach qi deficiency type ulcerative colitis and preparation method |
| CN105560553A (en) * | 2015-12-30 | 2016-05-11 | 青岛市第三人民医院 | Traditional Chinese medicinal preparation for treating chronic colitis, and preparation method thereof |
-
2016
- 2016-07-30 CN CN201610643119.XA patent/CN106063810A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103845391A (en) * | 2012-12-06 | 2014-06-11 | 鲜丹科 | Weichangrexuezhi |
| CN103656319A (en) * | 2013-12-15 | 2014-03-26 | 高继绪 | Application for treating acute radiation-induced esophagitis |
| CN104958645A (en) * | 2015-07-25 | 2015-10-07 | 王璐 | Traditional Chinese medicine for treating gastric ulcer |
| CN105343734A (en) * | 2015-11-29 | 2016-02-24 | 马良 | Traditional Chinese medicine for treating spleen and stomach qi deficiency type ulcerative colitis and preparation method |
| CN105560553A (en) * | 2015-12-30 | 2016-05-11 | 青岛市第三人民医院 | Traditional Chinese medicinal preparation for treating chronic colitis, and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 南京中医药大学: "《中药大辞典 第2版 上》", 30 June 2014, 上海科学技术出版社 * |
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| 钟鸣 等: "《常用壮药100种》", 30 April 2013, 广西民族出版社 * |
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Application publication date: 20161102 |