CN103638251A - Traditional Chinese medicinal preparation for treating acute radiation-induced esophagitis - Google Patents
Traditional Chinese medicinal preparation for treating acute radiation-induced esophagitis Download PDFInfo
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- CN103638251A CN103638251A CN201310723806.9A CN201310723806A CN103638251A CN 103638251 A CN103638251 A CN 103638251A CN 201310723806 A CN201310723806 A CN 201310723806A CN 103638251 A CN103638251 A CN 103638251A
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Abstract
The invention discloses a traditional Chinese medicinal preparation for treating acute radiation-induced esophagitis. In traditional Chinese medicine, radiation is toxic heat, which is easy to result in impairment of fluid and qi, and in combination with pain in swallowing of radiation-induced esophagitis after radiotherapy and other symptoms, is consistent with features of 'toxic heat'. The traditional Chinese medicinal preparation is prepared from the following traditional Chinese medicines capable of clearing away heat and toxic materials, nourishing yin and promoting secretion of body fluid, clearing damp and relaxing sinews, and promoting detumescence and resolving stasis: Yunnan cowpea root, small-leaved pea treat fruit, tropic ageratum herb, sericeous cinquefoil root, dunn antiotrema root, all grass of highstalk razorsedge, bark of himalayan coralbean, cantonese speranskia, Passiflora wilsonii Hemsl and securidaca inappendiculata hassk. The traditional Chinese medicinal composition is prepared into a decoction; a clinical test shows that total effective rate of the traditional Chinese medicinal composition is 97.1%, which is obviously better than that of a control group, which is 77.1%; the traditional Chinese medicinal preparation is remarkable in curative effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis.
Background technology
Radiation esophagitis (radiation esophagitis, RE) be the dose limitation reaction that chest and head-neck malignant tumor patient occur while accepting radiotherapy, with normal esophageal mucosa in irradiation field, hyperemia, edema, erosion or inflammatory exudation to occur to sexually revise even ulcer, on its basis can concurrent infection a kind of disease that is feature.Usually show as clinically foreign body sensation after dysphagia companion pain, breastbone, burn feeling and feed postemphasis; doctor trained in Western medicine is prevented and treated radiation esophagitis and mainly be take the anti symptom treatment such as pain relieving spasmolytic, anti-inflammation, protection gastrointestinal mucosal as main; although can effectively alleviate partial symptoms; but its side effect also clearly, after the inhibition of immunologic function can being increased the weight of or be brought out concurrent infection, digestive tract hemorrhage, drug withdrawal, bounce etc.Radiotherapy is interrupted and treatment time prolongation can reduce therapeutic effect again.Applicant proves through clinical trial for many years, Chinese medicine prevention acute radiation-induced esophagitis not only curative effect is affirmed, is had no side effect but also be cheap, for improving body toleration, reduce the incidence rate of radiation esophagitis, there is significant curative effect alleviating pain aspect.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis.Acute radiation-induced esophagitis belongs to motherland's medical science " dysphagic ", " regurgitation " category.The traditional Chinese medical science thinks, lonizing radiation belong to the heresy of fire-toxin, the easiest impairment of body fluid consumption gas.Due to after combination with radiotherapeutic radiation esophagitis swallow the symptoms such as pain, meet the feature of " burning hot evil poison ".Therefore, it is generally acknowledged that its pathogenesis is the burning hot poison heresy of lonizing radiation generation, damage human body, invades internal organs, and intoxicating heat is flourishing, stomach-QI being unable to descend normally, and body fluid-deficiency causing blood-dryness, so that esophagus is dry and astringent, and food difficulty enters.Simultaneously because of being cruelly subject to exopathogen, phlegm resistance, indigestion, transformation and transportation of the spleen and stomach is lacked of proper care, so that phlegm retention superinverse.Pyretic toxicity is strongly fragrant for a long time, can occur blood stasis symptom again.The one side of its existing domination of pathogen, i.e. solidifying, the blood stasis of depressed, expectorant, has again the one side of deficiency in origin, i.e. depletion of body fluid causing lack of blood, pathologic feature is deficiency in origin and excess in superficiality.Treatment take that heat-clearing and toxic substances removing, YIN nourishing and the production of body fluid promoting, damp eliminating are active, detumescence is principle.
The object of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treatment acute radiation-induced esophagitis is made by the Chinese medicine of following weight portion: Radix Vignae yunnanensis 9-15 part, Fructus Caraganae Microphyllae 5-10 part, Herba Agerati Conyzoidis 15-25 part, Radix Potentillae sericophyllae 30-60 part, Radix Antiotrematis dunniani 9-15 part, Herba Scleriae Terrestris 15-25 part, Cortex erythrinae 6-12 part, Herba speranskiae cantonensis 40-50 part, Herba Passiflorae Wilsonii 9-15 part, Radix securidacae 3-6 part.
Preferred: Radix Vignae yunnanensis 12g, Fructus Caraganae Microphyllae 7g, Herba Agerati Conyzoidis 20g, Radix Potentillae sericophyllae 45g, Radix Antiotrematis dunniani 12g, Herba Scleriae Terrestris 20g, Cortex erythrinae 9g, Herba speranskiae cantonensis 45g, Herba Passiflorae Wilsonii 12g, Radix securidacae 5g.
Preparation method is made decoction by above-mentioned Chinese medicine decocting.
In side: Radix Vignae yunnanensis, Fructus Caraganae Microphyllae, Herba Agerati Conyzoidis heat-clearing and toxic substances removing, detumescence sore-throat relieving; Radix Potentillae sericophyllae promoting the production of body fluid to quench thirst, nourishing YIN, clearind deficient heat; Radix Antiotrematis dunniani yin nourishing tonify deficiency, heat-clearing and toxic substances removing; Herba Scleriae Terrestris, Cortex erythrinae, Herba speranskiae cantonensis are except rheumatism, the meridian dredging; Herba Passiflorae Wilsonii blood circulation promoting and blood stasis dispelling, relaxing muscles and tendons and activating QI and blood in the collateral; Radix securidacae promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain, clearing away heat and promoting diuresis.
Clinical data
1. physical data MethodsThe cases enrolled 70 examples, are divided into two groups at random.Treatment group 35 examples, male 25 examples, female's 10 examples, 61 years old mean age; Pulmonary carcinoma 28 examples, mediastinal tumor 7 examples, wherein row operator 9 examples.Matched group 35 examples, male 23 examples, female's 12 examples, 59 years old mean age; 29 Cases of Lung Cancer, mediastinal tumor 6 examples, row operator 11 examples.Two groups of clinical datas irradiate difference not statistically significant (P > 0.05) on total length at age, sex, irradiation accumulated dose and esophagus.。
2。Diagnostic criteria (1) has breast tumor radiotherapy history or is carrying out radiotherapy.(2) clinical manifestation: mediastinal tumor, the non-esophagus disease such as pulmonary carcinoma occurs in Patients During Radiotherapy that with primary disease, without the retrosternal pain of direct relation, feed burn feeling, swallows discomfort, there is feed pain in severe patient, thereby fears feed.In radiotherapy in esophageal carcinoma patients, except occurring above-mentioned symptom, feed difficulty obviously increases the weight of before treating.Have a medical check-up general without obvious sign.(3) esophagogram shows that mucosa is disorderly, blocks and increases the weight of, and tube chamber is less.The visible exposure Esophageal Mucosa of endoscopy is congested, edema, and even pseudomembrane forms.
3. Therapeutic Method treatment group is taken Chinese medicine preparation of the present invention, takes Radix Vignae yunnanensis 12g, Fructus Caraganae Microphyllae 7g, Herba Agerati Conyzoidis 20g, Radix Potentillae sericophyllae 45g, Radix Antiotrematis dunniani 12g, Herba Scleriae Terrestris 20g, Cortex erythrinae 9g, Herba speranskiae cantonensis 45g, Herba Passiflorae Wilsonii 12g, Radix securidacae 5g.Decocting is made decoction, and 10 times/d, 20mL/ time, after taking medicine, 5min prohibits drinking-water.The gargarism that during matched group radiation treatment, conventional application normal saline, sodium bicarbonate, lignocaine are made into is gargled or buccal to patient.
4. criterion of therapeutical effect is effective: swallow pain and dysphagia disappears substantially; Take a turn for the better: swallow pain and (or) dysphagia obviously alleviates; Invalid: swallowing pain and dysphagia has and alleviate or constant.
5. two groups of therapeutic effect treatment observe the curative effect after 10 days continuously.In treatment group 35 examples, effective 23 examples (65.7%), effective 11 examples (31.4%), invalid 1 example (2.9%), total effective rate is 97.1%; In matched group 35 examples, effective 11 examples (31.4%), effective 16 examples (45.7%), invalid 8 examples (22.9%), total effective rate is 77.1%.Two groups of total effective rate comparing differences have significant (P < 0.05), and treatment group therapeutic effect is obviously better than matched group.
The specific embodiment
Embodiment mono-: take Radix Vignae yunnanensis 12g, Fructus Caraganae Microphyllae 7g, Herba Agerati Conyzoidis 20g, Radix Potentillae sericophyllae 45g, Radix Antiotrematis dunniani 12g, Herba Scleriae Terrestris 20g, Cortex erythrinae 9g, Herba speranskiae cantonensis 45g, Herba Passiflorae Wilsonii 12g, Radix securidacae 5g, take above-mentioned Chinese medicine decocting is become to decoction.
Embodiment bis-takes Radix Vignae yunnanensis 15g, Fructus Caraganae Microphyllae 10g, Herba Agerati Conyzoidis 25g, Radix Potentillae sericophyllae 60g, Radix Antiotrematis dunniani 9g, Herba Scleriae Terrestris 15g, Cortex erythrinae 12g, Herba speranskiae cantonensis 40g, Herba Passiflorae Wilsonii 9g, Radix securidacae 3g, takes above-mentioned Chinese medicine decocting is become to decoction.
Embodiment tri-: take Radix Vignae yunnanensis 9g, Fructus Caraganae Microphyllae 5g, Herba Agerati Conyzoidis 15g, Radix Potentillae sericophyllae 30g, Radix Antiotrematis dunniani 15g, Herba Scleriae Terrestris 25g, Cortex erythrinae 6g, Herba speranskiae cantonensis 50g, Herba Passiflorae Wilsonii 15g, Radix securidacae 6g, take above-mentioned Chinese medicine decocting is become to decoction.
Claims (2)
1. treat a Chinese medicine composition for acute radiation-induced esophagitis, it is characterized in that this Chinese medicine composition made by the Chinese medicine of following weight portion: Radix Vignae yunnanensis 9-15 part, Fructus Caraganae Microphyllae 5-10 part, Herba Agerati Conyzoidis 15-25 part, Radix Potentillae sericophyllae 30-60 part, Radix Antiotrematis dunniani 9-15 part, Herba Scleriae Terrestris 15-25 part, Cortex erythrinae 6-12 part, Herba speranskiae cantonensis 40-50 part, Herba Passiflorae Wilsonii 9-15 part, Radix securidacae 3-6 part.
2. a kind of Chinese medicine composition for the treatment of acute radiation-induced esophagitis according to claim 1, is characterized in that this Chinese medicine composition made by the Chinese medicine of following weight portion: Radix Vignae yunnanensis 12g, Fructus Caraganae Microphyllae 7g, Herba Agerati Conyzoidis 20g, Radix Potentillae sericophyllae 45g, Radix Antiotrematis dunniani 12g, Herba Scleriae Terrestris 20g, Cortex erythrinae 9g, Herba speranskiae cantonensis 45g, Herba Passiflorae Wilsonii 12g, Radix securidacae 5g.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104971237A (en) * | 2014-04-09 | 2015-10-14 | 张梅 | Traditional Chinese medicine combined preparation for treating radiation esophagitis |
CN105343553A (en) * | 2015-12-02 | 2016-02-24 | 王海莲 | Traditional Chinese medicine oral buccal tablet for treating radiation esophagitis, and preparation method of traditional Chinese medicine oral buccal tablet |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1586585A (en) * | 2004-07-16 | 2005-03-02 | 福州海王金象中药制药有限公司 | Shenghong heat clearing capsule |
CN101053593A (en) * | 2006-04-14 | 2007-10-17 | 徐燕和 | Shenghong heat-clearing granule and its preparation method |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN1586585A (en) * | 2004-07-16 | 2005-03-02 | 福州海王金象中药制药有限公司 | Shenghong heat clearing capsule |
CN101053593A (en) * | 2006-04-14 | 2007-10-17 | 徐燕和 | Shenghong heat-clearing granule and its preparation method |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104971237A (en) * | 2014-04-09 | 2015-10-14 | 张梅 | Traditional Chinese medicine combined preparation for treating radiation esophagitis |
CN105343553A (en) * | 2015-12-02 | 2016-02-24 | 王海莲 | Traditional Chinese medicine oral buccal tablet for treating radiation esophagitis, and preparation method of traditional Chinese medicine oral buccal tablet |
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