CN104435525A - Traditional Chinese medicine composition for preventing and treating bacterial endocarditis and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for preventing and treating bacterial endocarditis and preparation method of traditional Chinese medicine composition Download PDFInfo
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- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
The invention discloses a traditional Chinese medicine composition for preventing and treating bacterial endocarditis. The traditional Chinese medicine composition is prepared from the following active pharmaceutical ingredients in parts by weight: 5-15 parts of tender catchweed bedstraw herb, 15-19 parts of turpinia arguta seen, 10-30 parts of slender shad, 6-16 parts of obovateleaf actinodaphne bark, 5-18 parts of water chestnuts, 3-9 parts of drug sweetflag rhizome, 9-18 parts of Ningpo yam rhizome, 8-14 parts of earthworm, 3-9 parts of Indian bread with pine, 10-25 parts of radix salviae miltiorrhizae and 10-30 parts of cassia twigs. The traditional Chinese medicine composition disclosed by the invention is based on the principle of traditional Chinese medicine disease prevention and treatment by differentiation of symptoms. The selected medicinal materials contain not only medicines for bacteriostasis, but also medicines for replenishing heart and tranquilizing spirit, as well as medicines for promoting metabolism, and the active pharmaceutical ingredients with various effects are mutually matched together to prepare the traditional Chinese medicine composition for preventing and treating bacterial endocarditis.
Description
Technical field
The present invention relates to traditional Chinese medicine field, especially relate to a kind of Chinese medicine composition preventing and treating bacterial endocarditis and preparation method thereof.
Background technology
Endocardium is the innermost layer of heart, comprises the valve of heart and atrium and ventricle wall.After antibacterial enters blood, travel round each organ of whole body with blood.When flowing through heart, because of atrium and ventricle wall smooth, stop of can not stopping over.But when valve has inflammation or damage, antibacterial can stop, and at this growth and breeding, and causes valve inflammation.In addition, when having atrial septal defect or ventricular septal defect, blood flow forms vortex through defect, and antibacterial also can stop at defect place and cause inflammation.So bacterial endocarditis is more common in the ill child of congenital heart disease or acquired heart disease.
All there is heating during bacterial endocarditis, and be long-term fever, mostly be irregular pattern of fever, medium degree or high heat.There is cardiopathic child to exceed two weeks as heating, when there is no more other system symptom, the possibility of bacterial endocarditis should be considered.General Symptoms still depressed, the headache of spiritedness, uncomfortable in chest, breathe hard, inappetence etc.The performance of heart aspect increases the weight of on original basis, occurs cardiac insufficiency symptom.Valve becomes with the inflammation at defect place, can vegetation be formed, become embolus, when coming off with blood flow thromboembolism at some organ.The embolus of right side heart generally causes pulmonary infarction, and the embolus of left cardiac at brain, spleen, kidney generation thromboembolism, can occur corresponding symptom.Wherein cerebral embolism is the most serious, is in peril of one's life.During splenic embolish, spleen increases, and hematuria appears in renal infarction.
Heart is super to be checked, can find that endocardium has vegetation to exist, can confirm as bacterial endocarditis bacterial endocarditis need prevent and treat with antibiotic, application intravenous injection, and the time to grow, after body temperature is normal, still week is used again in face, certainly also will see endocardial pathological changes situation.Nursing the most important thing is to prevent embolus from coming off, Timeliness coverage thromboembolism, key is control activity, comes off because embolus easily occurs in mistake multi-activity.Ill child's absolute bed rest.Once had ill child to go to lavatory down because of oneself, result there occurs cerebral embolism, cerebral hemorrhage and dead.The head of a family must keep this point firmly in mind.As headache, dizzy, vomiting appear in ill child, namely should expect cerebral embolism occurs.Still can see hemiplegia, namely the upper and lower extremities of side is stiff.Making regular check on routine urinalysis, as there is hematuria, renal infarction being described.Occur that cough, spitting of blood, prompting have pulmonary infarction.Have and during cerebral embolism, to have the sequela such as limb activity is dumb, nursing will give the massage, acupuncture, medical gymnastics, blood circulation promoting, helps limbs to reactivate, and prevents amyotrophy.
The Chinese patent of application publication number CN 102600387 A (application number 201210080021.X) discloses a kind of Chinese herbal and crude drugs preparations for the treatment of acute viral myocarditis accompanied by bowel sepsis, its composition and ratio by: get Rhizoma Coptidis 100g, Flos Lonicerae 120g, Fructus Forsythiae 120g, Folium Isatidis 150g, Rhizoma Arisaematis 150g, Rhizoma Osmundae 120, Radix Pseudostellariae 150, Radix Ophiopogonis 100g, Radix Rehmanniae 150g, Radix Puerariae 150g, Radix Sophorae Flavescentis 120g, Herba Lophatheri 100g, Gypsum Fibrosum 200g, method for making summer 120g, the Radix Aucklandiae 30, Herba Hedyotis cantonensis 100g, Radix Glycyrrhizae Preparata 120g, Radix Glycyrrhizae 80g, Radix Ginseng 50g, green tea 30g, glucose 500g, get said herbal medicine material and green tea low baking temperature dry roasting dry after be sealed to 1 large bag bagged granules preparation for subsequent use, or get said herbal medicine material and green tea low baking temperature dry roasting dry after be distributed into the herbal tea preparation for subsequent use of the packed sealing of 10-30 parcel, glucose is packed in addition, is mainly used in prevention and therapy new trouble disorder heat-toxicity heart-disoperation type acute viral myocarditis, pericarditis, endocarditis, accompanied by bowel sepsis and viral enteritis or toxic intestinal scorching, viral influenza, viral parotitis, the diseases such as rubella, it can only play the object of taking stopgap measures, but can not effect a permanent cure.
Summary of the invention
For the reason that above-mentioned bacterial endocarditis is formed, an object of the present invention is the Chinese medicine composition providing control bacterial endocarditis, have non-stimulated, effective, feature easy to patients, the present invention adopts Chinese crude drug comparatively common in the localities as raw material, forms through special processing technique manufacture.
Another object of the present invention is just to provide the preparation method of above-mentioned Chinese medicine composition.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
The Chinese medicine composition of control bacterial endocarditis, the weight proportion of each crude drug is as follows, is weight portion:
The Chinese medicine composition of aforementioned control bacterial endocarditis, preferred scheme, the weight proportion of each crude drug is as follows, is weight portion:
The Chinese medicine composition of aforementioned control bacterial endocarditis, better preferred scheme, the weight proportion of each crude drug is as follows, is weight portion:
The preparation method of the Chinese medicine composition of control bacterial endocarditis, step is as follows:
(1) Ilisha elongata is cleaned removing internal organs, head and thorn, cut long 2 centimetres, the bar of wide 1 centimetre, be placed in marmite, pour vinegar into and soak intense fire after 1-3 hour and be fried open, turn 10-30 minute at a simmer, take out Ilisha elongata, be exposed to the sun in the sunlight 1-3 days (preferably 2 days), obtain dry Ilisha elongata bar, filtrate is for subsequent use;
(2) Pheretima, Turpinia pomifera(Roxb) D O., Rhizoma Arisaematis and Rhizoma Dioscoreae Nipponicae are placed in step (1) gained filtrate, after mix homogeneously, the slightly vexed 1-3 hour of cover lid, obtains mixed material medicine;
(3) be placed in pressure cooker by Corm Eleocharitis, Rhizoma Acori Graminei, Poria cum Radix Pini and Radix Salviae Miltiorrhizae, water proof heats, and steams to crude drug variable color, taking-up is dried in the air cool, mixing with step (2) gained mixed material medicine is more together placed in crock, after stirring, adds 5-7 times of water gaging, every tile, crock is heated, after intense fire is boiled, drop into Herba Galii Teneri and Ramulus Cinnamomi rapidly, turn slow fire boiling 20-40 minute (preferably 30 minutes), flame-out, leave standstill and get supernatant after 1-5 hour, supernatant is for subsequent use;
(4) dry for step (1) gained Ilisha elongata bar is ground to form smalls, join in step (3) gained supernatant, namely sterile packaged obtains target product.
The preparation method of above-mentioned Chinese medicine composition, the consumption of step (1) vinegar is the 1-5 of Ilisha elongata weight doubly (preferred, the consumption of vinegar is 2-4 times of Ilisha elongata weight, and more preferably good, the consumption of vinegar is 3 times of Ilisha elongata weight).
The preparation method of above-mentioned Chinese medicine composition, step (1) pour into vinegar soak intense fire after 1.5-2.5 hour be fried open (preferably pour into vinegar soak 2 hours after intense fire be fried open).
The preparation method of above-mentioned Chinese medicine composition, step (1) turns 15-25 at a simmer minute (preferably turning 20 minutes at a simmer).
The preparation method of above-mentioned Chinese medicine composition, slightly vexed 1.5-2.5 hour of cover lid (after preferred mix homogeneously slightly vexed 2 hours of cover lid) after step (2) mix homogeneously.
The preparation method of above-mentioned Chinese medicine composition, step (3) adds the water (preferably adding the water of 6 times amount) of 5.5-6.5 times amount.
The preparation method of above-mentioned Chinese medicine composition, step (3) leaves standstill gets supernatant (preferred, to leave standstill and get supernatant after 3 hours) after 2-4 hour.
For making this medicine reach best prevention effect, when taking, getting gained medicinal liquid 20-60g of the present invention, taking respectively at half an hour after breakfast, lunch and dinner, 5 days is a course for the treatment of.
This Chinese medicine composition, to bacterial endocarditis Be very effective, has rapid-action, the feature that cure rate is high, takes this Chinese medicine composition stomach and has not a particle of uncomfortable sensation, the local common medical material of multiselect of the present invention, cheap, alleviates the financial burden of patient.
The pharmacological effect of each crude drug is respectively:
Herba Galii Teneri: have another name called saw grass, draw rattan, fly upward rattan, the herb of taste Rubiaceae clivers Herba Galii Teneri or thick Ye Lala rattan.The property of medicine: herb is very thin, easily broken, the grayish green or green and brown color in surface, feeble QI, acrid in the mouth, bitter in the mouth, cold nature.Composition: Herba Galii Teneri aerial parts is containing alkaloid, and fruit contains Fructus Hordei Germinatus amine, jaligonic acid etc.; Thick Ye Lala rattan aerial parts contains asperuloside, vitamin C.Find according to modern pharmacological research, this medical instrument has antibacterial, anticancer, heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, reducing swelling and alleviating pain effect, for swollen ulcer drug, and appendicitis, cold, fever, hematuria etc.
Turpinia pomifera(Roxb) D O.: have another name called two to point sword at, seven cun of nails, be root or the leaf of the sharp sharp Turpinia pomifera(Roxb) D O. of Staphyleaceae Turpinia pomifera(Roxb) D O. platymiscium.The property of medicine: bitter in the mouth, cold in nature.Composition: its leaf is containing ursolic acid, and chromocor compound rutin, also contains myristic acid, daucosterol etc.Find according to modern pharmacological research, this medical instrument has antibacterial, antiinflammatory, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain effect, for traumatic injury, and spleen enlargement, pharyngolaryngitis etc.
Ilisha elongata: base is former: for clupeidae Chinese herring belongs to animal Chinese herring flesh of fish.Composition: meat is containing protein, fatty, calcium, phosphorus, ferrum, riboflavin, nicotinic acid and thiamine.The property of medicine: sweet, flat.Return spleen, stomach warp.Function cures mainly: spleen benefiting and stimulating the appetite, tranquilizing by nourishing the heart.Cure mainly diarrhea due to hypofunction of the spleen, dyspepsia, mouth of keeping silent is not eaten, severe palpitation.
Rhizoma Arisaematis: base is former: for Bryaceae rhodobryum spp plant warms up the plant of ground great Ye moss.Composition: plant contains volatile oil, flavonoid, steroidal, aminoacid, saccharide, glycoside, terpenoid etc.The property of medicine: pungent, bitter, flat.Function cures mainly: tranquilizing by nourishing the heart, liver heat removing and eyesight improving.Cure mainly severe palpitation, neurasthenia, conjunctival congestion and swelling pain, coronary heart disease etc.
Corm Eleocharitis: another name Horse hoof, black taro, Di Li.Flavor efficacy: sweet, cold.Function heat clearing away, reduce phlegm, removing food stagnancy, change wart.Be applicable to that epidemic febrile disease is quenched one's thirst, jaundice, pyretic stranguria, mass in the abdomen, conjunctival congestion, laryngopharynx swelling and pain, wart etc.Prevention acute infectious disease, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, diuresis relieving constipation is eliminated the phlegm, help digestion de-swelling, conditioning hemorrhoid or dysentery is had blood in stool, woman uterine bleeding, lung-dryness syndrome due to deficiency of YIN, phlegm-heat cough, discomfort in the throat, mass in the abdomen are gathered, conjunctival congestion is hidden from view, auxiliary effect such as to bring down a fever.In addition, Corm Eleocharitis contains a kind of antiviral substance can suppress epidemic encephalitis, influenza virus, can be used for the propagation preventing epidemic encephalitis and influenza.
Rhizoma Acori Graminei: another name Rhizoma Anemones Altaicae, water Rhizoma Acori Graminei, powder Chang, mountain Rhizoma Acori Graminei, small stream Chang, stone Scolopendra, wild leek.Flavor efficacy: pungent, flat or tepor.Enter the heart, liver, spleen channel.Fresh goods strong flavor, pungent loose power more wins than dry product, therefore the good merchantable brand for declaring gas sensible.This product had both been longer than removing dampness by means of aromatics, activating spleen and strengthening stomach, was used for the treatment of cloudy stagnant middle Jiao of turbid damp, vexed swollen, all diseases of anorexia of functional activity of QI being not smooth, breast gastral cavity; And again can fragrant magnificent expectorant turbid, resuscitation inducing and mind tranquilizing, is used for the treatment of the mind that turbid damp hoodwinks clearly caused by key dazed and confused, the disease of white and greasy fur; And arrogate to oneself the unconsciousness controlled expectorant heat and fall caused by stagnant pericardium, the diseases such as tic.
Rhizoma Dioscoreae Nipponicae: another name Dioscorea nipponica Mak. Ningpo Yam Rhizome, Rhizoma Dioscoreae Nipponicae, Dioscorea nipponica bone, ground joist, Rhizoma Smilacis Bockii, chicken bone, mountain Radix Dichroae, Radix Dichroae, parthenocissus, tip of a whip dish.Flavor efficacy is bitter, flat.Return liver, lung meridian.Function relaxing muscles and tendons to promote blood circulation, timid wind pain relieving, relieving cough and asthma, timid expectorant.Be applicable to lumbago and skelalgia, muscles and bones numbness, traumatic injury, lumbar sprain and QI divergeny, cough pant.
Pheretima: Pheretima is the dry body of Annelida Ju Yin section animal Pheretima aspergillum, popular Pheretimatschiliensis, power simulation or comb the region between the heart and the diaphragm hair earthworm.Heat clearing away is calmed the frightened, and dredging collateral, relievings asthma, diuresis; For cerebral thrombosis, cerebral infarction, coronary heart disease, apoplexy, joint is benumbed, numb limbs and tense tendons, hemiplegia, the diseases such as vascular hypertension.Be widely used in clinical at present, and be used in the heart, cerebrovascular, endocrine more and more, the prevention and treatment of diseases centers such as respiratory system.Be used for the treatment of calentura mania and irritation, infantile convulsion, cough with asthma, headache conjunctival congestion, laryngopharynx swelling and pain, urinary obstruction, Fengshi Guanjie pain, the diseases such as hemiplegia.External is coated with the disease such as erysipelas, dermatitis rhus.1. clearing heat for calming endogenous wind: cure mainly high fever infantile convulsion, wind symptom is twitched.2. lung-clearing asthma-relieving: the asthma of lung-heat productive cough can be controlled, better to lung heat type bronchial asthma curative effect.3. inducing diuresis for treating stranguria syndrome: be applicable to damp invasion of lower energizer, the puckery pain of pyretic stranguria.4. current meridians: available pyretic arthralgia of controlling saves swollen swelling pain; Suitable compatibility also can control arthralgia due to cold; Compatibility replenishing qi and promoting blood flow medicine is usually used in blood stasis due to qi deficiency, and meridians are unfavorable, aphasia hemiplegia person.
Poria cum Radix Pini: Poria cum Radix Pini to crouch the sclerotium of hole platymiscium Poria for Polyporaceae, and original kind is rudimentary plant, is the fungus colonized on pinaster.Medicinal effects is the white portion entertaining Radix Pini massonianae in the middle of dry sclerotia body.Nature and flavor are sweet, light flat.There are the functions such as eliminating dampness by diuresis, spleen invigorating, mind calming.For phlegm retention, edema, dysuria, have loose bowels, cardiopalmus, dizzy.Mind tranquilizing and the heart calming.Be applicable to the disease such as severe palpitation, insomnia forgetfulness.
Radix Salviae Miltiorrhizae: nature and flavor: bitter, is slightly cold.Gui Jing: GUIXIN, Liver Channel.Effect: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.Cure mainly: for menoxenia, amenorrhea dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Ramulus Cinnamomi: nature and flavor: acrid, sweet, warm.Gui Jing: GUIXIN, lung, urinary bladder channel.Effect: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Cure mainly: for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.
Chinese medicine composition of the present invention debates the principle of disease control based on Chinese medicine.In the medical material selected, existing antibacterial medicine, has again the medicine of heart tonifying and tranquilizing, the medicine enhanced metabolism in addition, and the crude drug of various effect cooperatively interacts the Chinese medicine composition of preparation cost invention for preventing and treating bacterial endocarditis together.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
Embodiment 1 prevents and treats the Chinese medicine composition of bacterial endocarditis, takes off the crude drug stating weight proportion and is prepared from (getting 10g for every part):
The preparation method of the Chinese medicine composition of above-mentioned control bacterial endocarditis, step is:
(1) Ilisha elongata is cleaned removing internal organs, head and thorn, cut long 2 centimetres, the bar of wide 1 centimetre, is placed in marmite, pour into vinegar soak 1 hour after intense fire be fried open, turn 10-minute at a simmer, take out Ilisha elongata, be exposed to the sun in the sunlight 1 day, obtain dry Ilisha elongata bar, the consumption of vinegar is 1 times of Ilisha elongata weight, and filtrate is for subsequent use;
(2) Pheretima, Turpinia pomifera(Roxb) D O., Rhizoma Arisaematis and Rhizoma Dioscoreae Nipponicae are placed in step (1) gained filtrate, after mix homogeneously, slightly vexed 1 hour of cover lid, obtains mixed material medicine;
(3) be placed in pressure cooker by Corm Eleocharitis, Rhizoma Acori Graminei, Poria cum Radix Pini and Radix Salviae Miltiorrhizae, water proof heats, and steams to crude drug variable color, taking-up is dried in the air cool, mixing with step (2) gained mixed material medicine is more together placed in crock, after stirring, adds 5 times of water gagings, every tile, crock is heated, after intense fire is boiled, drop into Herba Galii Teneri and Ramulus Cinnamomi rapidly, turn slow fire boiling 20 minutes, flame-out, leave standstill and get supernatant after 1 hour, supernatant is for subsequent use;
(4) dry for step (1) gained Ilisha elongata bar is ground to form smalls, join in step (3) gained supernatant, namely sterile packaged obtains target product.
Embodiment 2 prevents and treats the Chinese medicine composition of bacterial endocarditis, takes off the crude drug stating weight proportion and is prepared from (getting 15g for every part):
The preparation method of the Chinese medicine composition of above-mentioned control bacterial endocarditis, step is:
(1) Ilisha elongata is cleaned removing internal organs, head and thorn, cut long 2 centimetres, the bar of wide 1 centimetre, is placed in marmite, pour into vinegar soak 3 hours after intense fire be fried open, turn 30 minutes at a simmer, take out Ilisha elongata, be exposed to the sun in the sunlight 3 days, obtain dry Ilisha elongata bar, the consumption of vinegar is 5 times of Ilisha elongata weight, and filtrate is for subsequent use;
(2) Pheretima, Turpinia pomifera(Roxb) D O., Rhizoma Arisaematis and Rhizoma Dioscoreae Nipponicae are placed in step (1) gained filtrate, after mix homogeneously, slightly vexed 3 hours of cover lid, obtains mixed material medicine;
(3) be placed in pressure cooker by Corm Eleocharitis, Rhizoma Acori Graminei, Poria cum Radix Pini and Radix Salviae Miltiorrhizae, water proof heats, and steams to crude drug variable color, taking-up is dried in the air cool, mixing with step (2) gained mixed material medicine is more together placed in crock, after stirring, adds 7 times of water gagings, every tile, crock is heated, after intense fire is boiled, drop into Herba Galii Teneri and Ramulus Cinnamomi rapidly, turn slow fire boiling 40 minutes, flame-out, leave standstill and get supernatant after 5 hours, supernatant is for subsequent use;
(4) dry for step (1) gained Ilisha elongata bar is ground to form smalls, join in step (3) gained supernatant, namely sterile packaged obtains target product.
Typical case one: Wu xx, female, 25 years old, Jinan, Shandong Province Jiyang personage, suffered from congenital heart disease for many years, the appearance heating paresthesia of nearest unknown cause, and be long-term fever, irregular pattern of fever, medium degree or high heat, lassitude time the most serious, headache, uncomfortable in chest, breathe hard, inappetence, going examination in hospital to find is bacterial endocarditis.
Take embodiment 2 gained Chinese medicine composition, get gained medicinal liquid 60g of the present invention, take respectively at half an hour after breakfast, lunch and dinner, take 3 days, appetite increases, and symptom uncomfortable in chest alleviates, and has had no temperature, and continues to have taken 5 days, and patient's symptom that feels uneasy all disappears.
Embodiment 3: the Chinese medicine composition of control bacterial endocarditis, take off the crude drug stating weight proportion and be prepared from (getting 20g for every part):
The preparation method of the Chinese medicine composition of above-mentioned control bacterial endocarditis, step is:
(1) Ilisha elongata is cleaned removing internal organs, head and thorn, cut long 2 centimetres, the bar of wide 1 centimetre, is placed in marmite, pour into vinegar soak 1.5 hours after intense fire be fried open, turn 15 minutes at a simmer, take out Ilisha elongata, be exposed to the sun in the sunlight 1.5 days, obtain dry Ilisha elongata bar, the consumption of vinegar is 2 times of Ilisha elongata weight, and filtrate is for subsequent use;
(2) Pheretima, Turpinia pomifera(Roxb) D O., Rhizoma Arisaematis and Rhizoma Dioscoreae Nipponicae are placed in step (1) gained filtrate, after mix homogeneously, slightly vexed 1.5 hours of cover lid, obtains mixed material medicine;
(3) be placed in pressure cooker by Corm Eleocharitis, Rhizoma Acori Graminei, Poria cum Radix Pini and Radix Salviae Miltiorrhizae, water proof heats, and steams to crude drug variable color, taking-up is dried in the air cool, mixing with step (2) gained mixed material medicine is more together placed in crock, after stirring, adds 5.5 times of water gagings, every tile, crock is heated, after intense fire is boiled, drop into Herba Galii Teneri and Ramulus Cinnamomi rapidly, turn slow fire boiling 25 minutes, flame-out, leave standstill and get supernatant after 2 hours, supernatant is for subsequent use;
(4) dry for step (1) gained Ilisha elongata bar is ground to form smalls, join in step (3) gained supernatant, namely sterile packaged obtains target product.
Embodiment 4 prevents and treats the Chinese medicine composition of bacterial endocarditis, takes off the crude drug stating weight proportion and is prepared from (getting 25g for every part):
The preparation method of the Chinese medicine composition of above-mentioned control bacterial endocarditis, step is:
(1) Ilisha elongata is cleaned removing internal organs, head and thorn, cut long 2 centimetres, the bar of wide 1 centimetre, is placed in marmite, pour into vinegar soak 2.5 hours after intense fire be fried open, turn 25 minutes at a simmer, take out Ilisha elongata, be exposed to the sun in the sunlight 2.5 days, obtain dry Ilisha elongata bar, the consumption of vinegar is 4 times of Ilisha elongata weight, and filtrate is for subsequent use;
(2) Pheretima, Turpinia pomifera(Roxb) D O., Rhizoma Arisaematis and Rhizoma Dioscoreae Nipponicae are placed in step (1) gained filtrate, after mix homogeneously, slightly vexed 2.5 hours of cover lid, obtains mixed material medicine;
(3) be placed in pressure cooker by Corm Eleocharitis, Rhizoma Acori Graminei, Poria cum Radix Pini and Radix Salviae Miltiorrhizae, water proof heats, and steams to crude drug variable color, taking-up is dried in the air cool, mixing with step (2) gained mixed material medicine is more together placed in crock, after stirring, adds 6.5 times of water gagings, every tile, crock is heated, after intense fire is boiled, drop into Herba Galii Teneri and Ramulus Cinnamomi rapidly, turn slow fire boiling 35 minutes, flame-out, leave standstill and get supernatant after 4 hours, supernatant is for subsequent use;
(4) dry for step (1) gained Ilisha elongata bar is ground to form smalls, join in step (3) gained supernatant, namely sterile packaged obtains target product.
Model case two: grandson XX, female, 19 months large.The appearance " pneumonia " that regular flu, recurrent respiratory tract infection are even serious, poorer than general child's growth promoter, become thin, hyperhidrosis, evening, sleep was not stable, suck unable, difficulty of breast-feeding during sucking, going examination in hospital to find is geneogenous heart disease, because child is too little, household economy is also bad, do not perform an operation to child, but household fears that it can cause bacillary intimitis, many places are asked about and are learnt Chinese medicine composition of the present invention.
Take embodiment 4 gained Chinese medicine composition, get gained medicinal liquid 20g of the present invention, take respectively at half an hour after breakfast, lunch and dinner, when taking 2 days, sensation child sucked effectively, continues to take 3 days, going examination in hospital to find can be well antibacterial, sterilization, has good curative effect to the bacillary intimitis of control.
Embodiment 5: the Chinese medicine composition of control bacterial endocarditis, take off the crude drug stating weight proportion and be prepared from (getting 30g for every part):
The preparation method of the Chinese medicine composition of above-mentioned control bacterial endocarditis, step is:
(1) Ilisha elongata is cleaned removing internal organs, head and thorn, cut long 2 centimetres, the bar of wide 1 centimetre, is placed in marmite, pour into vinegar soak 2 hours after intense fire be fried open, turn 20 minutes at a simmer, take out Ilisha elongata, be exposed to the sun in the sunlight 2 days, obtain dry Ilisha elongata bar, the consumption of vinegar is 3 times of Ilisha elongata weight, and filtrate is for subsequent use;
(2) Pheretima, Turpinia pomifera(Roxb) D O., Rhizoma Arisaematis and Rhizoma Dioscoreae Nipponicae are placed in step (1) gained filtrate, after mix homogeneously, slightly vexed 2 hours of cover lid, obtains mixed material medicine;
(3) be placed in pressure cooker by Corm Eleocharitis, Rhizoma Acori Graminei, Poria cum Radix Pini and Radix Salviae Miltiorrhizae, water proof heats, and steams to crude drug variable color, taking-up is dried in the air cool, mixing with step (2) gained mixed material medicine is more together placed in crock, after stirring, adds 6 times of water gagings, every tile, crock is heated, after intense fire is boiled, drop into Herba Galii Teneri and Ramulus Cinnamomi rapidly, turn slow fire boiling 30 minutes, flame-out, leave standstill and get supernatant after 3 hours, supernatant is for subsequent use;
(4) dry for step (1) gained Ilisha elongata bar is ground to form smalls, join in step (3) gained supernatant, namely sterile packaged obtains target product.
Experimental example (embodiment 5 gained Chinese medicine composition): in order to verify the effect of Chinese medicine composition of the present invention, we have extracted 300 patients in 4 hospitals and have carried out the experiment of medicine, test group 200 people, matched group 100 people, experimental group takes embodiment 5 gained Chinese medicine composition, matched group takes the medicine of other control bacterial endocarditis, inclusion criteria: through being diagnosed as congenital heart disease and acquired heart disease patient, have bacterial endocarditis clinical symptoms one or more.Instructions of taking: when taking, gets gained medicinal liquid 20-60g of the present invention, takes respectively at half an hour after breakfast, lunch and dinner, within 5 days, is a course for the treatment of.Curative effect situation criterion: effectively, after taking this product, malaise symptoms alleviates or partial disappearance, well can prevent and treat bacterial endocarditis; Invalid, after taking this product, malaise symptoms is unchanged.We have carried out accurate statistics and mathematical analysis to experimental data.Specific experiment result is as following table:
Table 1: two groups of Clinical efficacy comparison [example] tables 1
Chinese medicine composition of the present invention has significant curative effect to control bacterial endocarditis, urticaria Patients Patients in various degree can be prevented and treated, obvious effective rate is up to 96%, severe patient took gained Chinese medicine composition of the present invention after 2 days, symptom also can alleviate, the Chinese medicine composition of this invention is cheap, evident in efficacy, and the present invention a kind ofly prevents and treats bacterial endocarditis safety and Chinese medicine composition without any side effects.
Claims (10)
1. prevent and treat the Chinese medicine composition of bacterial endocarditis, it is characterized in that: the weight proportion of each crude drug is as follows, is weight portion:
2. the Chinese medicine composition of control bacterial endocarditis according to claim 1, is characterized in that: the weight proportion of each crude drug is as follows, is weight portion:
3. the Chinese medicine composition of control bacterial endocarditis according to claim 1, is characterized in that: the weight proportion of each crude drug is as follows, is weight portion:
4. the preparation method of the Chinese medicine composition of the control bacterial endocarditis according to any one of claim 1-3, is characterized in that: step is as follows:
(1) Ilisha elongata is cleaned removing internal organs, head and thorn, cut long 2 centimetres, the bar of wide 1 centimetre, be placed in marmite, pour vinegar into and soak intense fire after 1-3 hour and be fried open, turn 10-30 minute at a simmer, take out Ilisha elongata, be exposed to the sun in the sunlight 1-3 days (preferably 2 days), obtain dry Ilisha elongata bar, filtrate is for subsequent use;
(2) Pheretima, Turpinia pomifera(Roxb) D O., Rhizoma Arisaematis and Rhizoma Dioscoreae Nipponicae are placed in step (1) gained filtrate, after mix homogeneously, the slightly vexed 1-3 hour of cover lid, obtains mixed material medicine;
(3) be placed in pressure cooker by Corm Eleocharitis, Rhizoma Acori Graminei, Poria cum Radix Pini and Radix Salviae Miltiorrhizae, water proof heats, and steams to crude drug variable color, taking-up is dried in the air cool, mixing with step (2) gained mixed material medicine is more together placed in crock, after stirring, adds 5-7 times of water gaging, every tile, crock is heated, after intense fire is boiled, drop into Herba Galii Teneri and Ramulus Cinnamomi rapidly, turn slow fire boiling 20-40 minute (preferably 30 minutes), flame-out, leave standstill and get supernatant after 1-5 hour, supernatant is for subsequent use;
(4) dry for step (1) gained Ilisha elongata bar is ground to form smalls, join in step (3) gained supernatant, namely sterile packaged obtains target product.
5. the preparation method of Chinese medicine composition according to claim 4, it is characterized in that: the consumption of step (1) vinegar is that the 1-5 of Ilisha elongata weight is doubly (preferred, the consumption of vinegar is 2-4 times of Ilisha elongata weight, more preferably good, the consumption of vinegar is 3 times of Ilisha elongata weight).
6. the preparation method of Chinese medicine composition according to claim 4, is characterized in that: step (1) pour into vinegar soak intense fire after 1.5-2.5 hour be fried open (preferably pour into vinegar soak 2 hours after intense fire be fried open).
7. the preparation method of Chinese medicine composition according to claim 4, is characterized in that: step (1) turns 15-25 at a simmer minute (preferably turning 20 minutes at a simmer).
8. the preparation method of Chinese medicine composition according to claim 4, is characterized in that: slightly vexed 1.5-2.5 hour of cover lid (after preferred mix homogeneously slightly vexed 2 hours of cover lid) after step (2) mix homogeneously.
9. the preparation method of Chinese medicine composition according to claim 4, is characterized in that: step (3) adds the water (preferably adding the water of 6 times amount) of 5.5-6.5 times amount.
10. the preparation method of Chinese medicine composition according to claim 4, is characterized in that: step (3) leaves standstill gets supernatant (preferred, to leave standstill and get supernatant after 3 hours) after 2-4 hour.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105250878A (en) * | 2015-10-30 | 2016-01-20 | 姜秀芹 | Traditional Chinese medicine for treating sub-acute infective endocarditis |
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| CN1586562A (en) * | 2004-07-07 | 2005-03-02 | 香港养春堂中药有限公司 | Card-otonic heart protecting pill |
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| CN1586562A (en) * | 2004-07-07 | 2005-03-02 | 香港养春堂中药有限公司 | Card-otonic heart protecting pill |
| EP2601958A1 (en) * | 2010-08-06 | 2013-06-12 | Tasly Pharmaceutical Group Co., Ltd. | Use of salvia miltiorrhiza composition in preparing drugs for secondary prevention of coronary heart disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105250878A (en) * | 2015-10-30 | 2016-01-20 | 姜秀芹 | Traditional Chinese medicine for treating sub-acute infective endocarditis |
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Application publication date: 20150325 |