CN104800300B - It is a kind of to prevent Chinese medicine composition of pig blue-ear disease and preparation method thereof - Google Patents
It is a kind of to prevent Chinese medicine composition of pig blue-ear disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition of prevention pig blue-ear disease, it is characterized in that, the bulk drug of the Chinese medicine composition includes the bighead atractylodes rhizome, giant knotweed, rhizome of cyrtomium, caulis lonicerae and radix glycyrrhizae, the ratio of weight and number of each bulk drug is 10 35 parts of the bighead atractylodes rhizome, 20 65 parts of giant knotweed, 10 35 parts of rhizome of cyrtomium, 25 75 parts of caulis lonicerae, 5 25 parts of radix glycyrrhizae.And it is a kind of prevent pig blue-ear disease Chinese medicine composition extraction process of effective component, and the Chinese medicine preparation comprising this Chinese medicine composition preparation method.There is clearing heat and detoxicating, antimicrobial and anti-inflammation efficacy according to the Chinese herbal granules that this programme is made, pig resistance against diseases can be strengthened, immunity is improved, as the Chinese medicine preparation of the blue otopathy of prevention, with good effect.
Description
Technical field
The invention belongs to veterinary medicament technical field, the Chinese medicine composition and its system of more particularly to a kind of prevention pig blue-ear disease
Preparation Method.
Background technology
Blue otopathy also known as porcine reproductive and respiratory syndrome（Porcine reproductive and respiratory
Syndrome, PRRS）The disease found that China found the disease first in 1996 in 1987 first in the U.S., and the current disease is
It is popular in worldwide, great economic loss is caused to pig industry.The harm of blue otopathy not only shows disease sheet
Damage and caused economic loss that body is caused to pig, most importantly infect after blue otopathy, host immune system are caused and exempted from
Epidemic disease suppresses, and easy secondary other bacteriums or virus infect and aggravates disease symptomses.
At present, to the also no particularly effective method for the treatment of of blue otopathy, use mostly：Antipyretic-antalgic agent, such as analgin,
An Jibilin, Bupleurum injection etc.；Antibiotic or sulfa drugs control bacterium scabies secondary infection, such as penicillin, streptomycin, head born of the same parents
Thiophene furan, tetracycline, sulphadiazine, the Sulfamonomethoxine injection of TMP sulfanilamide (SN) 6 etc.；Antiviral agent such as viral record, folium isatidis, plate
The injections such as Lan Gen, big Toxin-Vanquishing.The weak point that said medicine treatment pig blue-ear disease is present is that cost is higher, and therapeutic effect is not
It is preferable.
The content of the invention
In view of above-mentioned weak point, the present invention is by substantial amounts of research and puts into practice there is provided one kind with prevention pig blue-ear disease
Compound traditional Chinese medicine composite and its preparation method and application, the granule of said composition can be added to directly as feed addictive
In feed, livestock and fowl drinking water can also be directly mixed in, makes it in convenient and simple method of administration and while do not influence drug effect,
Its bioavilability can be improved.
In order to achieve the above object, present invention employs following technical scheme：
A kind of Chinese medicine composition of prevention pig blue-ear disease, the bulk drug of the Chinese medicine composition includes the bighead atractylodes rhizome, giant knotweed, passed through
Many, caulis lonicerae and radix glycyrrhizae, the ratio of weight and number of each bulk drug is 10-35 parts of the bighead atractylodes rhizome, and 20-65 parts of giant knotweed, 10-35 parts of rhizome of cyrtomium is born
Rattan 25-75 parts of winter, 5-25 parts of radix glycyrrhizae.
Preferably, the ratio of weight and number of each bulk drug is 10-15 parts of the bighead atractylodes rhizome, 20-30 parts of giant knotweed, 10-15 parts of rhizome of cyrtomium is born
Rattan 25-35 parts of winter, 5-10 parts of radix glycyrrhizae.
Preferably, the ratio of weight and number of each bulk drug is 25-35 parts of the bighead atractylodes rhizome, 50-65 parts of giant knotweed, 25-35 parts of rhizome of cyrtomium is born
Rattan 65-75 parts of winter, 15-25 parts of radix glycyrrhizae.
Preferably, the ratio of weight and number of each bulk drug is 20 parts of the bighead atractylodes rhizome, and 40 parts of giant knotweed, 20 parts of rhizome of cyrtomium, 50 parts of caulis lonicerae,
10 parts of radix glycyrrhizae.
Preferably, the bighead atractylodes rhizome is 2 with caulis lonicerae and the mass ratio of radix glycyrrhizae in the composition with rhizome of cyrtomium with giant knotweed:4:2:
5:1.A kind of Chinese medicine preparation for the Chinese medicine composition for preventing pig blue-ear disease, in addition to diluent and adhesive, the diluent is
Soluble starch, alpha-lactose, dextrin, are 3 according to mass ratio:1:1 mixture, adhesive is mass percent concentration 0.3%
Sodium carboxymethyl cellulose solution.
A kind of extraction process of effective component of the Chinese medicine composition of prevention pig blue-ear disease, by the bighead atractylodes rhizome, giant knotweed, rhizome of cyrtomium, honeysuckle
Rattan, the herbal mixture of radix glycyrrhizae composition be ground into after powder with 6-10 times measure volume mass than 50-75%V/V ethanol, backflow carries
Take 1-3 times, each 0.5-1.5h, merge extract solution, be then concentrated under reduced pressure, obtain the effective extract of herbal mixture.
A kind of preparation method of the Chinese medicine preparation of the Chinese medicine composition of prevention pig blue-ear disease, it is characterised in that including following
Step：
Herbal mixture effective extract is under agitation according to 1：5（Medicine liquid volume mL/ diluent quality g）Ratio dropwise
Add in diluent, then add adhesive and softwood is made；
The softwood made is crossed into a steel sieve series into wet granular, is placed in 55 DEG C of electric heating constant-temperature blowing drying boxes and dries；
Magnesia is added in dry particle, a sieve is crossed after mixing；
Particle by a sieve is put into No. five sieves, the particle on No. five sieves is collected, a kind of blue ear of prevention pig is obtained
The Chinese herbal granules of disease.
Through Chinese native medicine compound prescription pellet agent produced by the present invention, particle is uniform, and color and luster is consistent, and no moisture absorption, caking, deliquescence etc. are existing
As, meet Chinese veterinary pharmacopoeia requirement, it is quality controllable.
The present invention shows there is good effect for the prevention of pig blue-ear disease through pharmacodynamic study.In prescription of the present invention
Each component pharmacological effect is:
1. bighead atractylodes rhizome effect：Bighead atractylodes rhizome bitter；It is sweet；It is warm-natured.With strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, antiabortive effect.With
In spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, fetal irritability.
2. giant knotweed effect：Giant knotweed slight bitter, is slightly cold.Root-like stock hyoscine, have promoting blood circulation, dissipate the stasis of blood, stimulate the menstrual flow, antibechic the effects such as.
3. rhizome of cyrtomium effect：Rhizome of cyrtomium is terrestrial fern, and root-like stock is sturdy upright, leafage life, keratin, time winglike compound leaf of odd number,
Pinnule is in sickle shaped lanceolar, and there is serration at edge, and petiole is elongated close by brown fine, soft fur, and rhizome of cyrtomium has antiviral, Ceftriaxone
The effects such as treating biliary ascariasis.
4. caulis lonicerae effect：Caulis lonicerae has clearing heat and detoxicating, the curative effect of dispelling wind dredging collateral.Available for warm disease heating, sore carbuncle swells
Poison, toxic-heat and blood stasis, beriberoid pyretic arthralgia.
5. radix glycyrrhizae effect：Radix glycyrrhizae gas is micro-, taste sweet tea and it is special.Major function is clearing heat and detoxicating, expelling phlegm and arresting coughing, gastral cavity abdomen etc..Root and
Root-like stock hyoscine.
Prescription foundation of the present invention：This prescription is with strengthening vital QI to eliminate pathogenic factors, and enhancing pig premunition, diseases prevention ability, raising immunity are original
Then.Caulis lonicerae, radix glycyrrhizae, rhizome of cyrtomium are clearing heat and detoxicating main ingredient in side, and giant knotweed, the bighead atractylodes rhizome are antiviral, antibacterial adjuvant.All medicine phases in side
With common anti-inflammation can improve immunity of organisms and resistance against diseases.When the bighead atractylodes rhizome and giant knotweed and rhizome of cyrtomium and caulis lonicerae with it is sweet
The mass ratio of grass in the composition is 2:4:2:5:When 1, best results.
There is clearing heat and detoxicating, antimicrobial and anti-inflammation efficacy according to the Chinese herbal granules that this programme is made, pig resistance against diseases can be strengthened,
Immunity is improved, as the Chinese medicine preparation of the blue otopathy of prevention, with good effect.
Embodiment
Following non-limiting examples are used to illustrate the present invention.
Embodiment 1：
The herbal mixture of bighead atractylodes rhizome 20g, giant knotweed 40g, rhizome of cyrtomium 20g, caulis lonicerae 50g, radix glycyrrhizae 10g compositions is ground into after powder
With 10 times of amount volume mass than 60% ethanol, refluxing extraction 3 times, each 0.5h merges extract solution, is then concentrated under reduced pressure into every
The effective extract of milliliter crude drug containing 2g, it is 1 that mass ratio is then added dropwise under agitation:5 (medicine liquid volume is in terms of mL: dilution
Agent quality is in terms of g) diluent in, wherein diluent be soluble starch: alpha-lactose：The mass ratio of dextrin is 3:1:1 is uniform
Mixture；Then add the sodium carboxymethyl cellulose solution of 3-5 drops mass percent concentration 0.3% and be well mixed, be made compared with
Good softwood；The softwood made is put into number sieve of stainless steel and sieved, allows softwood granulating that wet granular is made by a sieve aperture；
Obtained wet granular is paved and is put into porcelain dish, and 15min is dried in 55 DEG C of electric heating constant-temperature blowing drying boxes, dry is made
Grain；1.5g magnesium oxide powders (magnesium oxide powder plays lubrication, can voluntarily adjust) are added in dry particle, are mixed
It is put into a sieve and sieves after even, the particle by a sieve is continued to be put into No. five sieves and sieved, is collected on No. five sieves
Particle, obtain it is a kind of prevent pig blue-ear disease Chinese herbal granules.
Embodiment 2：
The herbal mixture of bighead atractylodes rhizome 10g, giant knotweed 20g, rhizome of cyrtomium 10g, caulis lonicerae 25g, radix glycyrrhizae 5g compositions is ground into after powder
With 6 times of amount volume mass than 50% ethanol, refluxing extraction 1 time, each 1.5h merges extract solution, is then concentrated under reduced pressure into every
The effective extract of milliliter crude drug containing 2g, it is 1 that mass ratio is then added dropwise under agitation:5 (medicine liquid volume is in terms of mL: dilution
Agent quality is in terms of g) diluent in, wherein diluent is soluble starch: alpha-lactose: the mass ratio of dextrin be 3:1:1 is uniform
Mixture；Then add the sodium carboxymethyl cellulose solution of 3-5 drops mass percent concentration 0.3% and be well mixed, be made compared with
Good softwood；The softwood made is put into number sieve of stainless steel and sieved, allows softwood granulating that wet granular is made by a sieve aperture；
Obtained wet granular is paved and is put into porcelain dish, and 15min is dried in 55 DEG C of electric heating constant-temperature blowing drying boxes, dry is made
Grain；1.5g magnesium oxide powders (magnesium oxide powder plays lubrication, can voluntarily adjust) are added in dry particle, are mixed
It is put into a sieve and sieves after even, the particle by a sieve is continued to be put into No. five sieves and sieved, is collected on No. five sieves
Particle, obtain it is a kind of prevent pig blue-ear disease Chinese herbal granules.
Embodiment 3：
The herbal mixture of bighead atractylodes rhizome 25g, giant knotweed 50g, rhizome of cyrtomium 25g, caulis lonicerae 62.5g, radix glycyrrhizae 12.5g compositions is ground into powder
It is last with 8 times amount volume mass than 75% ethanol, refluxing extraction 2 times, each 1h, merge extract solution, be then concentrated under reduced pressure into
The effective extract of every milliliter of crude drug containing 2g, it is 1 that mass ratio is then added dropwise under agitation:5 (medicine liquid volume is in terms of mL: dilute
Agent quality is released in terms of g) diluent in, wherein diluent is soluble starch: alpha-lactose: the mass ratio of dextrin be 3:1:1 is equal
Even mixture；Then add the sodium carboxymethyl cellulose solution of 3-5 drops mass percent concentration 0.3% and be well mixed, be made
Preferable softwood；The softwood made is put into number sieve of stainless steel and sieved, allows softwood granulating to be made wet by a sieve aperture
Grain；Obtained wet granular is paved and is put into porcelain dish, and 15min is dried in 55 DEG C of electric heating constant-temperature blowing drying boxes, is made dry
Particle；1.5g magnesium oxide powders (magnesium oxide powder plays lubrication, can voluntarily adjust) are added in dry particle,
It is put into a sieve and sieves after mixing, the particle by a sieve is continued to be put into No. five sieves and sieved, No. five sieves are collected
On particle, obtain it is a kind of prevent pig blue-ear disease Chinese herbal granules.The foregoing is merely illustrative of the preferred embodiments of the present invention,
It is not intended to limit the invention, any modifications, equivalent substitutions and improvements made within the spirit and principles of the invention etc.,
It should be included in the scope of the protection.
Compliance test result：
It regard 1-3 of the embodiment of the present invention as experiment of preventive effects of the functional living being feed addictive to pig blue-ear disease, 100
Only the negative weanling pig of the blue otopathy of 30 ages in days is randomly divided into 5 groups, is denoted as I, II, III, IV, V group.I group is low dose group
(0.5%, (Chinese herbal granules quality/feeding quality %))；II group is middle dose group (1%)；III group is high dose group (2%)；IV group
For Tilmicosin control group；V group be blank control group (not dosing group), every group 20, and carry out continuous 15 days spice protect
It is strong, the average weight gain of each group is counted after 40 days, quantity, blue otopathy antigen PCR verification and measurement ratios is extremely washed in a pan.As a result it is as follows：
The above results show that the herbal mixture granule of the present invention has good prevention effect for pig blue-ear disease, and it is imitated
Fruit is suitable with Tilmicosin, but is current advocate using green the drawbacks of its drug resistance and medicament residue without chemical antimicrobial
The nontoxic preferable potential drug selection of Chinese medicine compound prescription prevention pig blue-ear disease.
Claims (7)
1. a kind of Chinese medicine composition of prevention pig blue-ear disease, it is characterised in that the bulk drug of the Chinese medicine composition is by the bighead atractylodes rhizome, tiger
Cane, rhizome of cyrtomium, caulis lonicerae and radix glycyrrhizae constitute, and the parts by weight of each bulk drug are：10-35 parts of the bighead atractylodes rhizome, 20-65 parts of giant knotweed, rhizome of cyrtomium 10-
35 parts, 25-75 parts of caulis lonicerae, 5-25 parts of radix glycyrrhizae.
2. a kind of Chinese medicine composition of prevention pig blue-ear disease as claimed in claim 1, it is characterised in that the weight of each bulk drug
Number is：10-15 parts of the bighead atractylodes rhizome, 20-30 parts of giant knotweed, 10-15 parts of rhizome of cyrtomium, 25-35 parts of caulis lonicerae, 5-10 parts of radix glycyrrhizae.
3. a kind of Chinese medicine composition of prevention pig blue-ear disease as claimed in claim 1, it is characterised in that the weight of each bulk drug
Number is：25-35 parts of the bighead atractylodes rhizome, 50-65 parts of giant knotweed, 25-35 parts of rhizome of cyrtomium, 65-75 parts of caulis lonicerae, 15-25 parts of radix glycyrrhizae.
4. a kind of Chinese medicine composition of prevention pig blue-ear disease as claimed in claim 1, it is characterised in that the weight of each bulk drug
Number is：20 parts of the bighead atractylodes rhizome, 40 parts of giant knotweed, 20 parts of rhizome of cyrtomium, 50 parts of caulis lonicerae, 10 parts of radix glycyrrhizae.
5. the Chinese medicine composition of a kind of prevention pig blue-ear disease as claimed in claim 1, it is characterised in that the bighead atractylodes rhizome and giant knotweed
It is 2 with rhizome of cyrtomium and caulis lonicerae and the mass ratio of radix glycyrrhizae in the composition:4:2:5:1.
6. a kind of include the Chinese medicine preparation of any one of the claim 1-5 Chinese medicine compositions, it is characterised in that also including dilution
Agent and adhesive, the diluent are soluble starch, alpha-lactose, dextrin, are 3 according to mass ratio:1:1 mixture, bonding
Agent is the sodium carboxymethyl cellulose solution of mass percent concentration 0.3%.
7. the extraction process of effective component of the Chinese medicine composition as described in claim any one of 1-5, it is characterised in that will be white
Art, giant knotweed, rhizome of cyrtomium, caulis lonicerae, radix glycyrrhizae composition herbal mixture be ground into after powder with 6-10 times measure volume mass than 50-
75%V/V ethanol, refluxing extraction 1-3 times, each 0.5-1.5h merges extract solution, is then concentrated under reduced pressure, obtains Chinese medicine composition
Active ingredient.
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| CN105053741A (en) * | 2015-09-23 | 2015-11-18 | 青岛华仁技术孵化器有限公司 | Feed capable of preventing and treating porcine reproductive and respiratory syndrome |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078419A (en) * | 2010-12-24 | 2011-06-01 | 任先武 | Medicament for preventing and treating porcine reproductive and respiratory syndrome (PRRS) and preparation method thereof |
| CN102688305A (en) * | 2012-06-11 | 2012-09-26 | 殷中琼 | Chinese medicine preparation for controlling livestock escherichia coli diseases as well as preparation method and application thereof |
| CN102772703A (en) * | 2012-08-02 | 2012-11-14 | 山西双鹰动物药业有限公司 | Drug for treating porcine reproductive and respiratory syndrome |
| CN104069478A (en) * | 2014-07-26 | 2014-10-01 | 施瑞客（天津）生物技术有限公司 | Traditional Chinese medicine composition for preventing and treating porcine reproductive and respiratory syndrome and preparation method thereof |
| CN104258047A (en) * | 2014-10-11 | 2015-01-07 | 青岛华仁技术孵化器有限公司 | Traditional Chinese medicine composition for preventing and treating porcine reproductive and respiratory syndrome |
-
2015
- 2015-05-14 CN CN201510244449.7A patent/CN104800300B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078419A (en) * | 2010-12-24 | 2011-06-01 | 任先武 | Medicament for preventing and treating porcine reproductive and respiratory syndrome (PRRS) and preparation method thereof |
| CN102688305A (en) * | 2012-06-11 | 2012-09-26 | 殷中琼 | Chinese medicine preparation for controlling livestock escherichia coli diseases as well as preparation method and application thereof |
| CN102772703A (en) * | 2012-08-02 | 2012-11-14 | 山西双鹰动物药业有限公司 | Drug for treating porcine reproductive and respiratory syndrome |
| CN104069478A (en) * | 2014-07-26 | 2014-10-01 | 施瑞客（天津）生物技术有限公司 | Traditional Chinese medicine composition for preventing and treating porcine reproductive and respiratory syndrome and preparation method thereof |
| CN104258047A (en) * | 2014-10-11 | 2015-01-07 | 青岛华仁技术孵化器有限公司 | Traditional Chinese medicine composition for preventing and treating porcine reproductive and respiratory syndrome |
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Effective date of registration: 20220427 Address after: 621100 Luxi Industrial Development concentration area, Santai County, Mianyang City, Sichuan Province Patentee after: Sichuan tieqilishi Food Co.,Ltd. Address before: 621006 161, middle section of Fei Yun Road, Mianyang new and high tech Zone, Sichuan. Patentee before: SICHUAN TQLS INDUSTRY Co.,Ltd. |
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Address after: 621100 Luxi Industrial Development concentration area, Santai County, Mianyang City, Sichuan Province Patentee after: Tieqi Lishi Food Co.,Ltd. Address before: 621100 Luxi Industrial Development concentration area, Santai County, Mianyang City, Sichuan Province Patentee before: Sichuan tieqilishi Food Co.,Ltd. |