CN103830713A

CN103830713A - Medicine for treating chicken wind-cold cough and asthma and preparation method thereof

Info

Publication number: CN103830713A
Application number: CN201410103548.9A
Authority: CN
Inventors: 李佃场; 黄河
Original assignee: Shandong New Hope Liuhe Group Co Ltd
Current assignee: Guangzhou Hope Feed Co., Ltd.
Priority date: 2014-03-20
Filing date: 2014-03-20
Publication date: 2014-06-04
Anticipated expiration: 2034-03-20
Also published as: CN103830713B; CN105688171A; CN105688171B

Abstract

The invention discloses a medicine for treating chicken wind-cold cough and asthma and a preparation method thereof. The medicine disclosed by the invention comprises the following raw herbal materials: pinellia ternate, poria cocos, ginger, Chinese honey locust, perillaseed, pericarpium citri reticulatae, mangnolia officinalis, semen brassicae, platycodon grandiflorum, concentrated beef extract, seed of Chinese waxgourd, folia perillae acutae, Chinese tamarisk twig, almond, inula flower, cynanchum glaucescens, common adenostema herb, gray gum, centipeda minim, mount wutai mushroom, watermeion peel, schizonepeta, sium latifolium, Chinese parsnip root and liquorice. The medicine disclosed by the invention has the beneficial effects that the medicine has the curative effects of reducing phlegm, relieving cough, relieving asthma, relieving exterior syndrome and dispelling cold and has the advantages of being obvious in curative effect, low in side effect, high in cure rate, short in treatment course, difficult for relapse and the like for treating chicken wind-cold cough and asthma.

Description

Be used for the treatment of medicine of chicken wind-cold type cough and preparation method thereof

Technical field

The present invention relates to herbal medicine technical field, particularly a kind of medicine that is used for the treatment of chicken wind-cold type cough and preparation method thereof.

Background technology

Chicken is normally breathing per minute 20～40 times, and it is exactly to breathe heavily that frequency of respiration is accelerated.Have with mouth breathing and stridulate.Chicken breathed heavily in night the most easily to be recognized when chicken group is quiet.High temperature, stifling etc. stress make chicken accelerated breathing, and one or more diseases can make chicken breathe heavily and have other respiratory symptoms, and what have is called " respiratory complication (levying) " or directly claims " respiratory symptom of chicken ", " respiratory tract disease ".

The existing antibacterial of chicken cough cause of disease, also has virus, some appearance mixed infection.Traditional Chinese veterinary medicine is thought the heresy of diseases caused by exogenous pathogenic factor six climate exopathogens, the criminal's of accumulateing lung in pathogenic factor, and sputum blocks trachea, causes cough and asthma, and then the evil edema caused by disorder of QI that passes, checks lung machine, so that clear respectful mistake department, the heap soil or fertilizer over and around the roots of QI rising in reverse order expectorant, it is unfavorable to breathe.Disease is seen heating, fervescence 1-2 DEG C, thirsty, dehisces to pant, and stretches neck and faces upward head, breathes and has rale sound, and night, more some trouble pertussis went out with blood streak sputum, the congested swelling of pharyngolaryngeal mucosa, coating pseudomembrane, hat whisker purple.Serious trouble chicken coma is slow-witted vertical, and the paralysis of even twitching, until dead.

Chinese veterinarian thinks, breathes heavily disease and refers to due to diseases caused by exogenous pathogenic factor or internal injury, causes impairment of dispersing and descending function of the lung, abnormal rising of lung-QI or gas without lead, kidney loses and takes the photograph and receive, so that dyspnea etc. is a kind of disease of main clinical characteristics.Breathe heavily disease ancient literature and also claim " breath ", " dyspnea with elevated shoulders ", " upper gas ", " contrary gas ", " dyspnea with rapid and short breath " etc."Nei Jing" has more discussion to breathing heavily disease.As " Ling Shu Miraculous Pivot or Divine Axis five is read five and made " said: " therefore lung patient, dyspnea and flaring of nares." " Plain Questions lift pain opinion " add: " the labor sweating of panting." point out to breathe heavily the existing diseases caused by exogenous pathogenic factor of the disease cause of disease, also there is internal injury, pathogenesis also has deficiency and excess not.In addition, " Plain Questions numbness opinion " cloud: " obstruction of heart-QI person, arteries and veins is obstructed, and tired severe palpitation is cruelly gone up gas and breathes heavily." " Plain Questions passages through which vital energy circulates another matter " cloud; " pendant probably, is breathed heavily for liver to some extent." though prompting breathes heavily taking lung as main, also relates to that it is dirty.The cause of disease of breathing heavily disease is very complicated, exopathogen invasion and attack, improper diet, etc. all can become the cause of disease of breathing heavily disease, cause impairment of dispersing and descending function of the lung, abnormal rising of lung-QI or gas without lead, kidney loses to take the photograph to receive just to become breathes heavily disease.The heresy of exopathogen invasion and attack affection of exogenous wind-cold or wind heat, fails to show in time to fall apart, and heresy is accumulate in lung, stops up resistance lung qi, and lung qi must not be declared and be fallen, thereby superinverse is breathed heavily.If kidney yang is weak, the not main water of kidney, violates on pathogenic water, and dry lung is insulted the heart, abnormal rising of lung-QI, and flaccidity of the heart-yang, also can cause and breathe heavily, and this belongs to the time of deficiency complicated with excess.Breathe heavily the sick position of disease, main dirty at lung and kidney, relevant with liver, spleen, the heart.Because of the lung being the dominator of QI, department breathes, and closes fur outward, and interior be the canopy of the five internal organs, if exopathogen is attacked lung, or violates on its disease of ZANG-organs gas, all can make obstruction of lung-QI, and impairment of dispersing and descending function of the lung is breathed unfavorable and caused dyspnea with rapid and short breath, or makes decline of lung-QI, and gas is become homeless and led and dyspnea with rapid and short breath.The kidney being the root of QI, with the cashier of lung with department's gas, therefore kidney unit is solid, takes the photograph and receives not normal gas and do not return unit, and negative and positive do not continue mutually, also can QI rising in reverse order in facies pulmonalis cordis for breathing heavily.If disturb on the turbid pathogenic fluid-retention of insufficiency of the spleen expectorant, or adverse flow of liver-QI also takes advantage of and can cause and breathe heavily, for the disease of liver spleen affects in lung.Obstruction of heart-QI with dyspnea, betides in collapse syndrome caused by dyspnea.

The pathologic feature of breathing heavily disease has deficiency and excess two classes.Excess-dyspnea is at lung, for exopathogen, expectorant are turbid, stagnation of liver-QI QI rising in reverse order, lung stop up pathogen and declare fall unfavorable; Dyspnea due to deficiency when lung, the kidney two of duty dirty, because of vital essence deficiency, gas the moon loss and cause the not main gas of lung, failure of the kidney in receiving QI.Therefore it is not normal to breathe heavily the basic pathogenesis of disease and be the lifting cashier of mechanism of qi, " be real at lung, is void at kidney ".The mixed person of the state of an illness, often can deficiency in the lower and excess in the upper, and simulataneous insufficiency and excessive is also shown in.But in the different phase of PD, between deficiency and excess, give priority to, or transform mutually.If pneumonopathy and spleen, child-organ disease involving its motherorgan, temper is also empty, insufficiency of the spleen mistake fortune, accumulatively wet raise phlegm, on steep in lung, obstruction of lung-QI, cloth is lost in gas Tianjin, blood is unfavorable, can form the turbid blood stasis of expectorant, now pathogenesis is taking the domination of pathogen as main, or the weakened body resistance cross-reference of the domination of pathogen.If protracted course of disease, involves in kidney, its pathogenesis presents kidney and loses and take the photograph and receive, the time of the excess of the lung of suffering from a deficiency of the kidney of expectorant stasis of blood volt lung.If deficient and weak YANG QI, water without lead, pathogenic water overflows, and can go up again icepro cardiopulmonary, pathogenesis is excess caused by deficiency, deficient and excessive syndromes appearing together.Chinese veterinarian's categorical identification in terms of causes of disease can be divided into four types: wind-cold type cough: fall ill more anxious, and tachypnea, with cough, rhinorrhea with clear discharge, ophthalmic has spumescence secretions, sends grunt in trachea, eyelid swelled, fear of cold squeezes heap; Phlegm-heat type cough with asthma: fall ill more anxious, cough dry and comfortable, xerostomia fever of the body, coughs sound pitch and out of breath, and larynx has rale, stretches neck mouth breathing, and expired gas is scorching hot, and nose flows thick tears, and some coughs are the mucus of expectoration band blood often, some sputums block throat, trachea, cause death by suffocation.Arrange green loose stool, some calculus ash water sample loose stools, amount of drinking water increases; Summer-wet type cough with asthma: summer summer heat in season, long summer dampness for contain.Invade chicken body when the heresy of heat-damp in summer, suffer from chicken performance spirit depressed, breathe out, some appearance are coughed or are had trachea rale, loss of appetite, and drink increases severely in advance, and crop swells, and has loose bowels, and growth of meat chicken is stagnated, and laying hen egg production declines; Void cough: mostly be obstinate disease, suffer from chicken faint, inappetence, exhales and inhale less more, even moving breathe heavily and have cough, but sound is low, short.

In recent years, it is local popular that the respiratory tract disease of chicken is at home, and general sickness rate is 30%～40%, and main manifestations is dyspnea, coughs, stridulates etc.Infect this after being ill, slowly or stagnate, laying hen egg yield significantly declines chick growth, and Mortality phenomenon appears in some morbidity chicken group, causes serious harm to poultry husbandry, causes larger economic loss.The environmental factorss such as the pathogenetic reason of chicken respiratory is very complicated, and the transmitted pathogens such as virus, antibacterial, Mycoplasma and air are unclean, temperature cataclysm are relevant, bring very large difficulty to clinical definite and control.This disease is mainly treated with vaccine prevention and chemicals and antibiotic etc. at present, and its effect is undesirable.

Summary of the invention

Technical problem to be solved by this invention is to provide a kind of and has expectorant cough suppressant and anti-asthmatic, the medicine that is used for the treatment of chicken wind-cold type cough of the curative effect of the cold expelling that induces sweat, and has advantages of good effect, short treating period, has no side effect at treatment chicken wind and cold cough.

In order to solve the problems of the technologies described above, the invention provides a kind of medicine that is used for the treatment of chicken wind-cold type cough with asthma, described medicine comprises following raw medicinal material: the Rhizoma Pinelliae, Poria, Rhizoma Zingiberis Recens, Fructus Gleditsia, Fructus Perillae, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Semen Sinapis Albae, Radix Platycodonis, Extract Carnis Bovis, Semen Benincasae, Folium Perillae, Cacumen Tamaricis, Semen Armeniacae Amarum, Flos Inulae, Rhizoma Cynanchi Stauntonii, adenostemma laveniaKuntze, gray gum, Herba Centipedae, platform mushroom, Exocarpium Citrulli, Herba Schizonepetae, Ou Zeqin, Radix Saposhnikoviae and Radix Glycyrrhizae.

Described medicine is preferably made up of the raw medicinal material of following parts by weight: Rhizoma Pinelliae 10-20 weight portion, Poria 15-25 weight portion, Rhizoma Zingiberis Recens 10-23 weight portion, Fructus Gleditsia 10-20 weight portion, Fructus Perillae 10-18 weight portion, Pericarpium Citri Reticulatae 20-30 weight portion, Cortex Magnoliae Officinalis 10-25 weight portion, Semen Sinapis Albae 10-20 weight portion, Radix Platycodonis 10-19 weight portion, Extract Carnis Bovis 10-18 weight portion, Semen Benincasae 10-20 weight portion, Folium Perillae 10-21 weight portion, Cacumen Tamaricis 10-20 weight portion, Semen Armeniacae Amarum 10-20 weight portion, Flos Inulae 10-20 weight portion, Rhizoma Cynanchi Stauntonii 10-18 weight portion, adenostemma laveniaKuntze 10-30 weight portion, gray gum 10-25 weight portion, Herba Centipedae 10-20 weight portion, platform mushroom 10-20 weight portion, Exocarpium Citrulli 10-19 weight portion, Herba Schizonepetae 10-24 weight portion, Ou Zeqin 10-19 weight portion, Radix Saposhnikoviae 10-20 weight portion and Radix Glycyrrhizae 10-30 weight portion.

Described medicine is preferably made up of the raw medicinal material of following parts by weight: Rhizoma Pinelliae 13-16 weight portion, Poria 19-23 weight portion, Rhizoma Zingiberis Recens 14-21 weight portion, Fructus Gleditsia 12-17 weight portion, Fructus Perillae 12-15 weight portion, Pericarpium Citri Reticulatae 23-28 weight portion, Cortex Magnoliae Officinalis 15-25 weight portion, Semen Sinapis Albae 12-16 weight portion, Radix Platycodonis 13-19 weight portion, Extract Carnis Bovis 10-15 weight portion, Semen Benincasae 14-20 weight portion, Folium Perillae 14-19 weight portion, Cacumen Tamaricis 12-18 weight portion, Semen Armeniacae Amarum 13-17 weight portion, Flos Inulae 13-20 weight portion, Rhizoma Cynanchi Stauntonii 13-18 weight portion, adenostemma laveniaKuntze 16-25 weight portion, gray gum 13-21 weight portion, Herba Centipedae 13-20 weight portion, platform mushroom 10-16 weight portion, Exocarpium Citrulli 10-14 weight portion, Herba Schizonepetae 14-20 weight portion, Ou Zeqin 13-19 weight portion, Radix Saposhnikoviae 13-18 weight portion and Radix Glycyrrhizae 15-23 weight portion.

Described medicine is preferably made up of the raw medicinal material of following parts by weight: the Rhizoma Pinelliae 15 weight portions, Poria 21 weight portions, Rhizoma Zingiberis Recens 17 weight portions, Fructus Gleditsia 14 weight portions, Fructus Perillae 14 weight portions, Pericarpium Citri Reticulatae 25 weight portions, Cortex Magnoliae Officinalis 20 weight portions, Semen Sinapis Albae 14 weight portions, Radix Platycodonis 16 weight portions, Extract Carnis Bovis 13 weight portions, Semen Benincasae 16 weight portions, Folium Perillae 16 weight portions, Cacumen Tamaricis 15 weight portions, Semen Armeniacae Amarum 15 weight portions, Flos Inulae 17 weight portions, Rhizoma Cynanchi Stauntonii 14 weight portions, adenostemma laveniaKuntze 21 weight portions, gray gum 16 weight portions, Herba Centipedae 17 weight portions, platform mushroom 13 weight portions, Exocarpium Citrulli 12 weight portions, Herba Schizonepetae 17 weight portions, Ou Zeqin 16 weight portions, Radix Saposhnikoviae 15 weight portions and Radix Glycyrrhizae 17 weight portions.

Described medicine preferably also comprises: rein in the horse back, Herba tetragoniae, Rhizoma Dioscoreae, Ganoderma and Fructus Crataegi.

Described medicine is preferably made up of the raw medicinal material of following parts by weight: Rhizoma Pinelliae 10-20 weight portion, Poria 15-25 weight portion, Rhizoma Zingiberis Recens 10-23 weight portion, Fructus Gleditsia 10-20 weight portion, Fructus Perillae 10-18 weight portion, Pericarpium Citri Reticulatae 20-30 weight portion, Cortex Magnoliae Officinalis 10-25 weight portion, Semen Sinapis Albae 10-20 weight portion, Radix Platycodonis 10-19 weight portion, Extract Carnis Bovis 10-18 weight portion, Semen Benincasae 10-20 weight portion, Folium Perillae 10-21 weight portion, Cacumen Tamaricis 10-20 weight portion, Semen Armeniacae Amarum 10-20 weight portion, Flos Inulae 10-20 weight portion, Rhizoma Cynanchi Stauntonii 10-18 weight portion, adenostemma laveniaKuntze 10-30 weight portion, gray gum 10-25 weight portion, Herba Centipedae 10-20 weight portion, platform mushroom 10-20 weight portion, Exocarpium Citrulli 10-19 weight portion, Herba Schizonepetae 10-24 weight portion, Ou Zeqin 10-19 weight portion, Radix Saposhnikoviae 10-20 weight portion, Radix Glycyrrhizae 10-30 weight portion, the 10-20 weight portion of reining in the horse back, Herba tetragoniae 10-20 weight portion, Rhizoma Dioscoreae 15-25 weight portion, Ganoderma 15-30 weight portion and Fructus Crataegi 10-15 weight portion.

Described medicine is preferably made up of the raw medicinal material of following parts by weight: the Rhizoma Pinelliae 15 weight portions, Poria 20 weight portions, Rhizoma Zingiberis Recens 17 weight portions, Fructus Gleditsia 15 weight portions, Fructus Perillae 14 weight portions, Pericarpium Citri Reticulatae 25 weight portions, Cortex Magnoliae Officinalis 18 weight portions, Semen Sinapis Albae 15 weight portions, Radix Platycodonis 14 weight portions, Extract Carnis Bovis 14 weight portions, Semen Benincasae 15 weight portions, Folium Perillae 16 weight portions, Cacumen Tamaricis 15 weight portions, Semen Armeniacae Amarum 15 weight portions, Flos Inulae 15 weight portions, Rhizoma Cynanchi Stauntonii 14 weight portions, adenostemma laveniaKuntze 20 weight portions, gray gum 17 weight portions, Herba Centipedae 15 weight portions, platform mushroom 15 weight portions, Exocarpium Citrulli 14 weight portions, Herba Schizonepetae 17 weight portions, Ou Zeqin 14 weight portions, Radix Saposhnikoviae 15 weight portions, Radix Glycyrrhizae 20 weight portions, 15 weight portions of reining in the horse back, Herba tetragoniae 15 weight portions, Rhizoma Dioscoreae 21 weight portions, Ganoderma 21 weight portions and Fructus Crataegi 12 weight portions.

The preparation method that a kind of medicine that is used for the treatment of chicken wind-cold type cough is also provided in order better to realize the present invention of foregoing invention object, described preparation method comprises the following steps:

Step 1, all raw medicinal materials are dropped in blender in proportion and stir, mix, after send in pulverizer and to pulverize, the Chinese medicine composition after pulverizing is packed in multi-function extractor, add with respect to the water of 5 ~ 7 times of amounts of its quality, boil 2 ~ 4 hours, steam pressure is that 0.6 ~ 1Mpa processes, filter, obtain the first filtrate and filtering residue;

Step 2, by the filtering residue of acquisition again add with respect to the water of 5 ~ 7 times of amounts of its quality, to boil 2 ~ 4 hours, steam pressure be that 0.6Mpa ~ 1Mpa processes, filter and obtain the second filtrate and filtering residue;

Step 3, the first filtrate and the second filtrate are merged, concentratedly remove moisture, obtain and get dry extract, adopt super-fine powder mill to pulverize, be crushed to below 30 μ m, obtain drug powder.

The beneficial effect that the technical scheme that the embodiment of the present invention provides is brought is: medicine of the present invention has expectorant cough suppressant and anti-asthmatic, the curative effect of the cold expelling that induces sweat, have evident in efficacy at treatment chicken wind-cold type cough, side effect is low, the advantages such as cure rate is high, short treating period, difficult recurrence.

Detailed description of the invention

The embodiment of the present invention provides a kind of medicine that is used for the treatment of chicken wind-cold type cough, comprises following raw medicinal material: the Rhizoma Pinelliae, Poria, Rhizoma Zingiberis Recens, Fructus Gleditsia, Fructus Perillae, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Semen Sinapis Albae, Radix Platycodonis, Extract Carnis Bovis, Semen Benincasae, Folium Perillae, Cacumen Tamaricis, Semen Armeniacae Amarum, Flos Inulae, Rhizoma Cynanchi Stauntonii, adenostemma laveniaKuntze, gray gum, Herba Centipedae, platform mushroom, Exocarpium Citrulli, Herba Schizonepetae, Ou Zeqin, Radix Saposhnikoviae and Radix Glycyrrhizae; Preferably, medicine preferably also comprises: rein in the horse back, Herba tetragoniae, Rhizoma Dioscoreae, Ganoderma and Fructus Crataegi.

Wherein, the pharmacological property of each raw medicinal material is as follows:

The Rhizoma Pinelliae: pungent, temperature, poisonous; Enter lung, spleen, stomach three warps." property of medicine opinion ": " preventing or arresting vomiting is told for expectorant saliva, appetite promoting and the spleen strengthening, goes expectorant in the heart to expire, lower lung qi, the main knot of coughing." " Japan hanako materia medica ": " and control and tell food regurgitation, cramp caused by acute vomiting and diarrhea, intestinal abdomen is cold, intermittent fever due to phlegm." the pungent loose warm-dryness syndrome of these product is poisonous, main enter taste double enter lung, the water of manageing it is wet, lowering the adverse flow of QI, and the kind taste damp-phlegm of dispelling.Water is wet goes the strong and sputum of spleen from disappearing, contrary gas harmonization of the stomach falls and feeling of fullness vomiting from only, therefore be drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the good medicine of dissolving lump and resolving mass.Both cured mainly the abundant expectoration cough with asthma QI rising in reverse order of spleen damp-phlegm heap soil or fertilizer over and around the roots, controlled again the dizzy palpitation and insomnia of violating on damp-phlegm, also can control wind-phlegm tell contrary, headache limb fiber crops, hemiplegia, the diseases such as facial hemiparalysis.

Poria: sweet, light, flat.GUIXIN warp, lung meridian, spleen channel, kidney channel.Function: diuretic medicine; Diuretics with the action of eliminating dampness." medication heart method ": " sweet with supporing yang, the panacea of dehumidifying also for Poria, the sharp key of light energy.The flat YANG invigorating of sweet in the mouth, strengthening the spleen is relieved oedema or abdominal distension through diuresis or purgation, the inducing QI of promoting the production of body fluid." modern study shows that the interaction energy many-side that Poria has an enhancing immunity regulates immunologic function.Poria has significant inhibitory action to staphylococcus aureus, Bacillus proteus.

Rhizoma Zingiberis Recens: Rhizoma Zingiberis Recens refers to the tuber stem of ginger, calls purple Rhizoma Zingiberis Recens, Rhizoma Zingiberis Recens, fresh ginger, old ginger.Warm in nature, its distinctive " gingerol " can stimulating gastrointestinal mucosa, make gastrointestinal tract hyperemia, digestion power strengthens, and can effectively treat the abdominal distention of eating cold and cool food and too much causing, stomachache, diarrhoea, vomiting etc.Ate after Rhizoma Zingiberis Recens, people has the sensation of health heating, and this is because it can distend the blood vessels, and blood circulation is accelerated, and impels pore with it to open, and so not only the unnecessary torrid zone can be walked, and also the pathogenic bacteria in body, cold is together taken out of simultaneously.Eat cold and cool thing when health, be subject to drench with rain or in air-conditioned room, stayed long afterwards, eaten Rhizoma Zingiberis Recens and just can eliminate in time because of the cold various discomforts that remake of human body.

Fructus Gleditsia: pungent, temperature; Enter lung, Liver Channel.Compendium of Material Medica: " Fructus Gleditsia acupuncture is controlled wind parasite killing, and merit and pod are same, the different ear but its sharp keen through disease is done." containing flavonoid glycoside, phenols, aminoacid.Flavone compound is fustin (fustin i.e. 3,7,3,4-tetrahydroxy flavanone), fisetin (fisetin i.e. 3,7,3,4-kaempferol), and contains leucocyanidin.Experiment in body, has the effect that suppresses active to turbid Mus S-180.The flat board method that burrows for decoct, has inhibitory action to staphylococcus aureus and micrococcus catarrhalis; Water logging agent 60g/kg gavage is 32.8% to the suppression ratio of S-180.Fructus Gleditsia is for attacking loose high strict product, broken without heavily fortified point, loose without expectorant, and energy switch intestinal stasis relieving,, can help meet an urgent need with it to unconsciousness due to blockage of phlegm disease.Outer infections head is outstanding, in bursting and not bursting, utilizes Fructus Gleditsia to break through its head, and to cut for cutter, defeated and dispersed power is quite strong.

Fructus Perillae: pungent, temperature.Return lung, large intestine channel." book on Chinese herbal medicine converges ": " Fructus Perillae, loose gas is very prompt, the upper and lower all gas of profit the most clearly, Dingchuan expectorant is meritorious, and can lead to two just, except anemofrigid-damp arthralgia.If the deficiency of vital energy and fullness in the chest person is also unavailable, or with the tonic Shi Yike that holds concurrently." " Japan hanako materia medica ": " and in homophony, beneficial the five internal organs, the therapeutic method to keep the adverse QI flowing downwards, only cholera, vomiting, regurgitation, tonify deficiency labor, fertile strong people, sharp defecation, broken knot, disappear five every, antitussive, profit ambition, eliminating phlegm-retention." sending down the abnormal ascending QI expectorant, relieving cough and asthma, loosening bowel to relieve constipation.Stop up QI rising in reverse order, cough and asthma, dryness of the intestine constipation for expectorant.Feed chicken with the feedstuff containing perilla oil, can make chicken plasma cholesterol levels reduce, the mycete of Bacillus proteus, Aspergillus niger, penicillium and occurring in nature is all had to inhibitory action, the ethanol extraction after defat has anticorrosion and antioxidation.

Pericarpium Citri Reticulatae: bitter, pungent, temperature.Return lung, spleen channel.Energy regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Temperature can circulation of qi promoting, and pungent can dispersing is bitter and sluice.Say from lung, pungent loose lung qi, hardship is let out lung qi, and temperatureization cold can be controlled abundant expectoration cough with asthma, and gas is stopped up food and is stopped; Pericarpium Citri tangerinae goes its words spoken by an actor from offstage person, is referred to as Exocarpium Citri Rubrum, and its arduous taste is heavier, is mainly used in damp eliminating reduces phlegm above therefore clinical, and especially abundant expectoration is stopped up in lung, as conventional patent medicine Juhong Wan and so on.Vascular aurantii has row QI of channels and collaterals, goes the effect of meridians phlegm-damp, therefore be used in clinically in the numb limbs and tense tendons of stagnation of QI causing phlegm retention, polygamy is among other Cheng Fang.The effect that Semen Citri Reticulatae has removing obstruction for relieving pain to dry to reduce phlegm, therefore clinically for hernia pain, the wet main numbness lumbago of Epileptic etc.Folium Citri tangerinae color green grass or young crops, has bar to reach the effect of irritability, therefore clinically for the pain over the hypochondriac region, in mastalgia uncomfortable in chest, also polygamy uses at Cheng Fangzhong.Cortex Magnoliae Officinalis: hardship, pungent, warm in nature; Return spleen channel, stomach warp, large intestine channel.Function: circulation of qi promoting removing food stagnancy, dampness is removed full, lowering the adverse QI to relieve asthma.Cortex Magnoliae Officinalis and volatile oil bitter in the mouth thereof can stimulate the sense of taste, reflexively cause the quickening of saliva, gastric secretion, gastrointestinal peristalsis, and have stomach invigorating digestion-aid effect.Experiment in vitro proves, Cortex Magnoliae Officinalis decoct all has antibacterial action to gram negative bacillis such as the gram positive bacterias such as staphylococcus, Hemolytic streptococcus, streptococcus pneumoniae, bordetella pertussis and anthrax bacillus, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus subtilis. and experiment shows, compare with other 61 kinds of Chinese medicines, Cortex Magnoliae Officinalis is the strongest to the effect of Staphylococcus albus, bacillus subtilis, escherichia coli and Bacillus typhi.Its bactericidal action that act as to Staphylococcus albus and bacillus subtilis.

Semen Sinapis Albae: acrid in the mouth, temperature, nontoxic.Enter the warp of liver, spleen, lung, stomach, the heart and collaterals of the uterus." Japan hanako materia medica ": " control the swollen and paralysis of pathogenic wind toxic, vinegar grind Fu it.Flutter damage blood stasis, lumbago kidney cold-peace Rhizoma Zingiberis Recens grinds, micro-warm, is coated with and pastes.Pained, wine vinegar takes it." Compendium of Material Medica: " Semen Sinapis Albae is pungent can enter lung, and temperature can be dispersed, therefore have promoting the circulation of QI eliminating phlegm, warming middle-JIAO appetizing, loose pain to subside a swelling, ward off the merit of evil." can remove cold air, settling five organs, by the expectorant of film diaphragm, wards off stealthy gas, the addiction that disappears malaria, the Dingchuan that drops interests, sharp key improving eyesight, removing blood stasis relieves the pain, and all can prove effective.Can energy dissipating fall, energy complementary energy liter, helps all tonics, the outstanding kind merit of receiving.Mustard flour, as flavoring agent, increases salivation and amylase activity, and heart size and heart rate are reduced.

Radix Platycodonis: bitter in the mouth, pungent, property is flat.Return lung meridian.There is lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, effect of filling blood, mend five kinds of over strain, fostering the spirit of nobility.Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus." herbal classic " said: " main chest and hypochondrium is as lancination, abdominal distention, borborygmus are faint, the gas of throbbing with fear in terror "." Japan hanako materia medica " said: " trusted subordinate's distending pain, mends five kinds of over strain, fosters the spirit of nobility for lower all gas, only cramp caused by acute vomiting and diarrhea, and evil removing is warded off temperature, tonify deficiency expectorant, and broken lump in the abdomen, the evacuation of pus of nourishing blood, mends internal hemorrhage due to trauma and sore throat ".Modern pharmacological research shows, Radix Platycodonis has and eliminates the phlegm and antitussive effect; Hypoglycemic activity; Suppress gastric secretion and antiulcer action; Antiinflammatory action; Calmness, analgesia and refrigeration function.

Extract Carnis Bovis: sweet in the mouth; Warm in nature.Return spleen channel.Function cures mainly: strengthening the spleen and stomach; Fill blood; Moistening the lung and resolving the phlegm.Main asthenia is won thin; Apoplexy is attached undue importance to one thing to the neglect of the other; Phlegm retention painful abdominal mass is long-pending; Skin sucutaneous nodule.

Semen Benincasae: feeble QI, taste is micro-sweet.Control phlegm-heat cough, lung abscess, acute appendicitis, gonorrhea, edema, beriberi, hemorrhoid, nasal surface wine Zha.After Semen Benincasae water extraction, through the dialyzed solution of dialysing to obtain, split agent for B cell causes silk, have clone B cell activator activity and adjuvanticity, can make plaque forming cells keep count of and significantly increase, present immunologic enhancement.From Semen Benincasae, separation and purification goes out 4 components, has the effect that suppresses trypsin vigor.

Folium Perillae: acrid in the mouth warm in nature, have induce sweat, cold expelling, the effect of regulating the flow of vital energy and seeking.Be applicable to the diseases such as cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen.Folium Perillae Herb all has very high nutritive value, and it has low sugar, high fiber, high carotene, high mineral element etc.In volatile oil, contain perillaldehyde, perilla alcohol, menthone, menthol, eugenol, ergomaketon etc.Defying age element SOD in every milligram of Folium Perillae content up to 106.2 micrograms.Find after deliberation, the each position of Folium Perillae evenly has good antitumaous effect, especially stronger with the effect in blade, oleanolic acid is wherein a kind of very strong natural anti-cancer agent, there is the effect of prophylaxis of tumours, there is again the effect of antiinflammatory, calmness, heart tonifying, diuresis, enhancing immunity, blood fat reducing and resistance growth of cancer cells.Folium Perillae can diaphoresis cold expelling to separate pathogenic factor in the exterior, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, resolving depression preventing or arresting vomiting, therefore wind and cold table disease is doublely seen to symptoms of emesis uncomfortable in chest, use this product, be very suitable; Or have the stagnation of QI not smooth symptom without table disease, also can be used for a surname logical.

Cacumen Tamaricis: sweet, pungent, flat.GUIXIN, lung, stomach warp.Function cures mainly: loose wind, induce sweat, and rash.For measles without adequate eruption, rheumatic arthralgia.

Semen Armeniacae Amarum: hardship, tepor; Slightly poisonous." Mingyi Bielu ": " almond core, adopt it May.Its two core person kills a person, can malicious Canis familiaris L..Raw Jin Shanchuangu." Shennong's Herbal: " main cough with dyspnea is thunderous, sore throat, the therapeutic method to keep the adverse QI flowing downwards, galactopoiesis incised wound, bitterly disappointed renal mass." " property of medicine opinion ": " control abdomen numbness obstructed, diaphoresis, main epidemic febrile disease.Control completely pain of spasm in the epigastrium, except trusted subordinate's unhappiness, treat lung qi cough, dyspnea.Enter Radix Asparagi and decoct, profit cardiopulmonary.Can make soup with cheese, benefit profit information.Place i.e. moving cold air." relieving cough and asthma, loosening bowel to relieve constipation.Collective Notes to the Canon of Materia medica: " obtain fiery good.Dislike Radix Astragali, Radix Scutellariae, Radix Puerariae.Wei Folium Zingiberis miogae." the bitter warm lung qi dispersing of Semen Armeniacae Amarum, loosening bowel to relieve constipation, be only suitable for the trouble of the excess syndrome such as ailment said due to cold or exposure, dryness of the intestine.All the moon loses, stagnated fire person, and unsuitable single medicinal material is for oral administration for a long time.As the disease taboo single medicinal materials such as pulmonary tuberculosis, bronchitis, chronic enteritis, dry cough without phlegm take for a long time.Correct edible Semen Armeniacae Amarum, can reach promoting the production of body fluid to quench thirst, lung moistening Dingchuan, laxation relieving constipation, effect of minimizing intestinal cancer.

Flos Inulae: salty, warm, slightly poisonous; Enter lung, liver, stomach warp.Function expectorant, the therapeutic method to keep the adverse QI flowing downwards, softening the hard mass, row water." herbal classic ": " main stagnation of QI, fullness in the hypochondrium, palpitation with fear.Dewater, remove cold and heat between the five internal organs, invigorating middle warmer, the therapeutic method to keep the adverse QI flowing downwards." " property of medicine opinion ": " main rib side of body gas, lower cold and heat edema, cures mainly bladder retained water, removes by large abdomen appetizing, the contrary not lower food of preventing or arresting vomiting." cure mainly in the heart expectorant knot, the lower distension of the side of body, cough with asthma, singultus, saliva is as shellac varnish, epigastric oppression Ying, eructation unrelieved, extensive abdominal edema.Chlorogenic acid has sensitization to people, sucks (as in coffee plant) after the dust of plant that contains chlorogenic acid, can pant, dermatitis etc., but can be through the effect of intestinal secretion thing after eating, become without allergenic substance, therefore test when sensitinogen, should be used Intradermal method without oral medication." Amplification on Materia Medica addendum ": " patient relates to empty person and should not take more, and sharp large intestine, guards against it.”

Rhizoma Cynanchi Stauntonii: pungent, bitter, tepor; Return lung meridian.. Tang Materia Medica: " Rhizoma Cynanchi Stauntonii, Ye Siliu, or like Flos Genkwa, height of seedling chi is permitted, on the desert of a small piece of land surrounded by water, raw continent.Root is white, is longer than Herba Asari, sweet in the mouth.Custom is with wine stain clothes, Zhu Shangqi.Not raw shortcut.Modern use climing survivor, bitter in the mouth, non-very also.". " herbal classic is met former ": " Rhizoma Cynanchi Stauntonii, compared with slightly temperature of Radix Cynanchi Atrati, slightly flat compared with Herba Asari.Specially search edema due to wind pathogen in lung key, if non-Radix Cynanchi Atrati is salty-cold, specially let out the scorching of lung, stomach, also do not alter like the pungent of Herba Asari, can control the heavy of kidney, liver and tremble with fear also." lowering the adverse-rising QI to resolve phlegm, cough-relieving.Cough with copious phlegm, asthma.This product slightly warm in nature and not dry strong, is longer than and eliminates the phlegm, and falls lung qi with flat cough with asthma.The no matter cold heat that belongs to of genus, Exogenous and internal injuries, newly cough chronic cough all available it.

Adenostemma laveniaKuntze: hardship, cold.Function cures mainly: clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Be used for catching a cold high hot, bronchitis, pharyngolaryngitis, tonsillitis, icterohepatitis; Carbuncle furuncle infections, venom are controlled in external.

Gray gum: pungent, micro-hardship, temperature.Function cures mainly: anti-inflammation and sterilization, expelling phlegm for arresting cough, convergence parasite killing.Be used for preventing influenza, epidemic encephalitis type B.Prevent and treat malaria, enteritis, diarrhoea, dysentery, skin ulceration, carbuncle skin ulcer redness, erysipelas, mastitis, trauma infection contamination, tinea, neurodermatitis.Also can control leptospirosis, tracheitis, cough, can kill maggot, smoked mosquito.

Herba Centipedae: energy dispersing wind-cold, clearing the nasal passage, cough-relieving, removing toxic substances, antipruritic." book on Chinese herbal medicine converges and says " cloud: " medicine of stuffy nose relieving gas also for Herba Centipedae, sharp nine orifices.Its acrid in the mouth is strong, and its gas is pungent smoked, and its property rises loose, can lead to lung meridian, above reaches brains, therefore the phlegm dyspnea of main Snore clam is gas-tight obstructed, the nasal polyp of having a stuffy nose, feeling of distension and oppression is unfavorable, goes cataracta in order, and in cold-evil, all diseases of wind syndrome of head headache, all get the loose merit of pungent temperature rise also ".Cough-relieving, antiasthmatic effect: this product volatile oil and ethanol extract part have cough-relieving, eliminate the phlegm, antiasthmatic effect.Volatile oil and ethanol extract part have some cough-relieving, eliminate the phlegm, antiasthmatic effect, and precipitation part cough suppressing effect is not obvious, without phlegm-dispelling functions.Experiment in vitro, decoct has inhibitory action to tubercule bacillus.Herb extract have obvious inhibitory action to beta-hydroxy-Beta-methyl 1,3-propanedicarboxylic acid (HMG) coenzyme A, calcium channel blocker and gallbladder contraction.

Platform mushroom: micro-salty, temperature.Function cures mainly: chase after wind, and cold expelling, relaxing muscles and tendons, active.For lumbago and skelalgia, numb hand and foot, grain does not relax.

Exocarpium Citrulli: sweet, light, cold.Be included into the heart, stomach warp.Cure mainly+clearing away summer-heat of function, the relieving restlessness of purging heat, diuresis.For summer-heat excessive thirst, oliguria with reddish urine, laryngopharynx swelling and pain, or aphtha of the mouth and tongue, the diseases such as edema.

Herba Schizonepetae: acrid in the mouth, micro-hardship, property is micro-wet; Enter lung, Liver Channel." Japan hanako materia medica ": " sharp the five internal organs, removing stagnancy of indigested food and making QI downward, relieving alcoholic intoxication.The heat-dissipating of cooking is eaten and is simmered tea, and controls wind syndrome of head and antiperspirant goes out; Semen Glycines preparatum decocts that to control violent trauma cold." " detailed outline ": " and loose wind heat, refresh oneself, throat, the skin ulcer that disappears is swollen.Control stiffness of the nape, black flower in order, and raw skin ulcer, cloudy ruined, spit blood, epistaxis, hematochezia, dysentery, metrorrhagia, anal fistula." main cold, fever, headache, eye itching, cough, laryngopharynx swelling and pain, measles, carbuncle, skin ulcer scabies, puerperal blood faints.For flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.Herba Schizonepetae decoct has stronger antibacterial action to staphylococcus aureus and diphtheria corynebacterium.Make fever in rabbits with typhoid fever polyvalent vaccine, give Schizonepeta tenuifolia decoct or ethanol preserved material 2g/kg gavage, find that there is faint refrigeration function.Herba Schizonepetae oil can reduce normal rat body temperature; Also have sedation, Herba Schizonepetae oil (0.5ml/kg) is given rabbit gavage, its movable minimizing as seen, and limb muscle is slightly lax.Herba Schizonepetae oil can obviously extend acetylcholine and histamine mixed liquor causes the incubation period of breathing heavily to Cavia porcellus, reduces the number of animals that tic occurs; The guinea pig tracheal smooth muscle that also can cause anti-acetylcholine or histamine is shunk; Still there is phlegm-dispelling functions.

Ou Zeqin: sweet in the mouth; Property is put down.Function cures mainly: wind-expelling pain-stopping; Blood pressure lowering.Main flu; Headache; Hypertension.

Radix Saposhnikoviae: acrid in the mouth, sweet, slightly warm in nature; Enter urinary bladder channel, lung meridian, spleen channel, Liver Channel." Japan hanako materia medica ": " wind as controlling 36, all labor of man are bad, invigorating middle warmer benefit god, blepharitis marginalis, arresting lacrimation and paralysis are slow, tonneau the five internal organs GUAN-pulse, five kinds of strain and seven kinds of impairment, thin damage night sweat, vexed body weight, energy tranquilizing the mind, even gaseous pulse." " Changsha medicine solution ": " and the network of passing through, by wet excessive, gets round by bribery, the pain that relieves the pain, and relaxing muscles and tendons arteries and veins, stretches anxious twinly, and the podomere of living, plays paralysis, holds back spontaneous perspiration, night sweat, breaks, metrorrhagia." function expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.For affection of exogenous wind-cold, headache general pain, rheumatic arthralgia, joint is ached, stomachache is had loose bowels, discharging fresh blood stool, tetanus, rubella pruritus, skin infection from the beginning of.Deficiency of YIN-blood, calentura wind symptom person should not use, and blood deficiency convulsion urgency or headache be not because ailment said due to cold or exposure person avoids clothes.

Radix Glycyrrhizae: nature and flavor are sweet, flat.Enter spleen, stomach, lung meridian." herbal classic " said: " main the five internal organs six mansion cold and heat pathogens, hard muscles and bones, longue meat, times power, incised wound is swollen, removing toxic substances ".People's the moon (no) " property of medicine opinion " is said: " cold type of pain in main abdomen, controls infantile convulsion, except distention and fullness in the abdomen; Tonification the five internal organs; Make all poison of drug; Support kidney qi internal injury, make flaccidity; Housewife's human blood drop lumbago; Void and frequent fever; Add and with it ".Can QI invigorating invigorating middle warmer, relieving spasm to stop pain, nourishing the lung to arrest cough, eliminating fire and detoxication, coordinating the actions of various ingredients in a prescription.Main asthenia lack of appetite, leanness yellowish complexion, shortness of breath and palpitation, stomachache loose stool, the anxious pain of extremity contraction, hysteria, cough and asthma, laryngopharynx swelling and pain, carbuncle skin ulcer swells and ache, infantile carbuncle, and medicine, alimentary toxicosis.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.Western modern medicine haircut is existing, and Radix Glycyrrhizae agent has the function of antiinflammatory and the reflection of resistance state, therefore in doctor trained in Western medicine clinically mainly as demulcent.Relieving cough, eliminates the phlegm, treatment pharyngalgia laryngitis; Radix Glycyrrhizae or enoxolone have the effect of desoxycortone class, and chronic adrenocortical hypofunction is had to good efficacy; Glycyrrhiza preparation can promote stomach mucus to form and secretion, extends the epithelial cell life-span, has anti-inflammatory activity, is usually used in the treatment of chronic ulcer and duodenal ulcer; The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect; Radix Glycyrrhizae is also one of primary raw material of rendan mini-pills.

Rein in the horse back: hardship, cold.Function cures mainly: lung heat clearing, reduce phlegm, and cough-relieving, removing toxic substances.For chronic tracheitis, pulmonary suppuration disease, coughs vomiting bloody pus; Hemorrhoid are controlled in external, skin eczema, and rubella is scratched where it itches, furuncle carbuncle skin infection.

Herba tetragoniae: sweet; Micro-pungent; Property is put down.Return lung; Liver; Large intestine channel.Function cures mainly: wind and heat dispersing; Removing toxic substances and promoting subsidence of swelling.The hot conjunctival congestion of main air; Treatment skin ulcer swells and ache; Intestinal inflammation; Septicemia; Tumor.

Rhizoma Dioscoreae: sweet in the mouth, property are put down, and enter lung, spleen, kidney channel; Not dry oiliness, there are strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, grow that will is calmed the nerves, effect of life lengthening; Cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity are weak, the red disease such as swollen, fat of the frequent micturition of quenching one's thirst, seminal emission premature ejaculation, leukorrhagia nebulousurine, skin.Compendium of Material Medica is summarized five large functions " kidney tonifying gas, strengthening the spleen and stomach, stopping leak dysentery, the saliva that reduces phlegm, profit skin ".Rhizoma Dioscoreae is cooked congee or simmers after ripe and take with crystal sugar, and, colitis poor to health, deficiency of the kidney chronic diseases are all effective in cure.Strengthen the spleen and stomach: treatment weakness of the spleen and stomach, have loose bowels, body is tired, lack of appetite, sweating due to debility.Lung benefiting nourishing kidney: this product is cold not dry, sweet in the mouth matter profit, can treat lung suffer from a deficiency of the kidney damage quench one's thirst, pass out semen, be with inferior disease.Be described as angle's medicine.

Ganoderma: property is sweet, flat.GUIXIN, lung, liver, kidney channel.Cure mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.Animal pharmacology shows experiment: Ganoderma has inhibitory action to nervous system, and blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, and respiratory system is had to phlegm-dispelling functions, in addition, also has hepatoprotective, improves immunologic function, antibacterially waits effect.

Fructus Crataegi: sour in the mouth, sweet, slightly warm in nature, enters spleen, stomach, Liver Channel, and for promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis, is mainly used to treat accumulation of food in the stomach and intes tine due to indigestion, have loose bowels, dysentery, Fructus Crataegi is the staple for the treatment of dyspepsia, Fructus Crataegi can increase the secretion of peptic digestion enzyme, facilitating digestion; Dysentery bacterium, bacillus pyocyaneus, staphylococcus aureus etc. are had to obvious inhibitory action.

Described medicine is made up of the raw medicinal material of following parts by weight: Rhizoma Pinelliae 10-20 weight portion, Poria 15-25 weight portion, Rhizoma Zingiberis Recens 10-23 weight portion, Fructus Gleditsia 10-20 weight portion, Fructus Perillae 10-18 weight portion, Pericarpium Citri Reticulatae 20-30 weight portion, Cortex Magnoliae Officinalis 10-25 weight portion, Semen Sinapis Albae 10-20 weight portion, Radix Platycodonis 10-19 weight portion, Extract Carnis Bovis 10-18 weight portion, Semen Benincasae 10-20 weight portion, Folium Perillae 10-21 weight portion, Cacumen Tamaricis 10-20 weight portion, Semen Armeniacae Amarum 10-20 weight portion, Flos Inulae 10-20 weight portion, Rhizoma Cynanchi Stauntonii 10-18 weight portion, adenostemma laveniaKuntze 10-30 weight portion, gray gum 10-25 weight portion, Herba Centipedae 10-20 weight portion, platform mushroom 10-20 weight portion, Exocarpium Citrulli 10-19 weight portion, Herba Schizonepetae 10-24 weight portion, Ou Zeqin 10-19 weight portion, Radix Saposhnikoviae 10-20 weight portion and Radix Glycyrrhizae 10-30 weight portion.

Described medicine can also be made up of the raw medicinal material of following parts by weight: the Rhizoma Pinelliae 15 weight portions, Poria 21 weight portions, Rhizoma Zingiberis Recens 17 weight portions, Fructus Gleditsia 14 weight portions, Fructus Perillae 14 weight portions, Pericarpium Citri Reticulatae 25 weight portions, Cortex Magnoliae Officinalis 20 weight portions, Semen Sinapis Albae 14 weight portions, Radix Platycodonis 16 weight portions, Extract Carnis Bovis 13 weight portions, Semen Benincasae 16 weight portions, Folium Perillae 16 weight portions, Cacumen Tamaricis 15 weight portions, Semen Armeniacae Amarum 15 weight portions, Flos Inulae 17 weight portions, Rhizoma Cynanchi Stauntonii 14 weight portions, adenostemma laveniaKuntze 21 weight portions, gray gum 16 weight portions, Herba Centipedae 17 weight portions, platform mushroom 13 weight portions, Exocarpium Citrulli 12 weight portions, Herba Schizonepetae 17 weight portions, Ou Zeqin 16 weight portions, Radix Saposhnikoviae 15 weight portions and Radix Glycyrrhizae 17 weight portions.

Described preparation method comprises the following steps:

Embodiment 1 medicine 1

The embodiment of the present invention provides a kind of medicine that is used for the treatment of chicken wind-cold type cough, raw medicinal material by parts by weight is made: the Rhizoma Pinelliae 15 weight portions, Poria 21 weight portions, Rhizoma Zingiberis Recens 17 weight portions, Fructus Gleditsia 14 weight portions, Fructus Perillae 14 weight portions, Pericarpium Citri Reticulatae 25 weight portions, Cortex Magnoliae Officinalis 20 weight portions, Semen Sinapis Albae 14 weight portions, Radix Platycodonis 16 weight portions, Extract Carnis Bovis 13 weight portions, Semen Benincasae 16 weight portions, Folium Perillae 16 weight portions, Cacumen Tamaricis 15 weight portions, Semen Armeniacae Amarum 15 weight portions, Flos Inulae 17 weight portions, Rhizoma Cynanchi Stauntonii 14 weight portions, adenostemma laveniaKuntze 21 weight portions, gray gum 16 weight portions, Herba Centipedae 17 weight portions, platform mushroom 13 weight portions, Exocarpium Citrulli 12 weight portions, Herba Schizonepetae 17 weight portions, Ou Zeqin 16 weight portions, Radix Saposhnikoviae 15 weight portions and Radix Glycyrrhizae 17 weight portions.

Preparation method is as follows:

Step 1, all raw medicinal materials are dropped in blender in proportion and stir, mix, after send in pulverizer and to pulverize, the Chinese medicine composition after pulverizing is packed in multi-function extractor, add with respect to the water of 6 times of amounts of its quality, boil 3 hours, steam pressure is that 0.8Mpa processes, filter, obtain the first filtrate and filtering residue;

Step 2, by the filtering residue of acquisition again add with respect to the water of 6 times of amounts of its quality, to boil 3 hours, steam pressure be that 0.8Mpa processes, filter and obtain the second filtrate and filtering residue;

Embodiment 2 medicines 2

The embodiment of the present invention provides a kind of medicine that is used for the treatment of chicken wind-cold type cough, raw medicinal material by following parts by weight is made: the Rhizoma Pinelliae 15 weight portions, Poria 20 weight portions, Rhizoma Zingiberis Recens 17 weight portions, Fructus Gleditsia 15 weight portions, Fructus Perillae 14 weight portions, Pericarpium Citri Reticulatae 25 weight portions, Cortex Magnoliae Officinalis 18 weight portions, Semen Sinapis Albae 15 weight portions, Radix Platycodonis 14 weight portions, Extract Carnis Bovis 14 weight portions, Semen Benincasae 15 weight portions, Folium Perillae 16 weight portions, Cacumen Tamaricis 15 weight portions, Semen Armeniacae Amarum 15 weight portions, Flos Inulae 15 weight portions, Rhizoma Cynanchi Stauntonii 14 weight portions, adenostemma laveniaKuntze 20 weight portions, gray gum 17 weight portions, Herba Centipedae 15 weight portions, platform mushroom 15 weight portions, Exocarpium Citrulli 14 weight portions, Herba Schizonepetae 17 weight portions, Ou Zeqin 14 weight portions, Radix Saposhnikoviae 15 weight portions, Radix Glycyrrhizae 20 weight portions, 15 weight portions of reining in the horse back, Herba tetragoniae 15 weight portions, Rhizoma Dioscoreae 21 weight portions, Ganoderma 21 weight portions and Fructus Crataegi 12 weight portions.

Described preparation method comprises the following steps:

Toxicity test

1, cumulative toxicity test report

Select 20 healthy mices, female, male each 10, taking the medicine of the embodiment of the present invention 1 as object, it is first phase that dosage designs every 5 days, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD 50,0.50LD50, and the LD 50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW).Within every 5 days, weigh once, adjust dosage, by 0.1ml/10 part BW per os gavage.After 20 days, animal occurs without death condition, off-test, and by ascending-dose, to tested material after 20 days, female, buck all occurs without death condition.Taking the Chinese medicine additive of embodiment 2 as object, carry out according to the method described above toxicity test, result is as identical in embodiment 1.

2, acute toxicity test

40 of application NIH mices, SPF level, male and female half and half, body weight 16～20g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, i.e. matched group and administration group, fasting 12 hours before experiment; Medicine dissolution prepared by embodiments of the invention 1 is in water, (concentration is 6.58g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 32.9 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Therefore the acute toxicity of the medicine of the embodiment of the present invention 1 is low, clinical drug safety.Taking the medicine of embodiment 2 as object, carry out according to the method described above toxicity test, result is as identical in embodiment 1.

Contrast test

In December, 2012, the AA broiler morbidity of 1500 21 ages in days that Tai’an, Shandong Province poultry specialist raises, fall ill two days nearly 1/3rd chicken be originally that stream nose, sneeze, ophthalmic have spumescence secretions, a couple of days, full chicken occurred sending snore in cough, dyspnea, trachea subsequently, feed intake obviously reduces, spirit is poor, is unwilling to walk about, and fear of cold squeezes heap.Pathology cuts open inspection: in nasal cavity, trachea, have mucus, air bag obviously thickens, and swelling around the eyes is swollen, can extrude lark grumeleuse.Be diagnosed as wind-cold type cough according to suffering from chicken symptom and pathological change.

Select 600 ill chickens, be divided at random three groups, embodiment group 1, embodiment group 2 and matched group.Embodiment group 1 is used the conventional feed that is added with the embodiment of the present invention 1 medicine, and medicine accounts for 5% of feedstuff gross weight, uses 3-5 days; Embodiment group 2 is used the conventional feed that is added with the embodiment of the present invention 2 medicines, and medicine accounts for 7% of feedstuff gross weight, uses 3-5 days; Matched group uses enrofloxacin and Buddha's warrior attendant to exhale larynx despot powder to treat, and adds enrofloxacin 55g, Buddha's warrior attendant is exhaled larynx despot powder 40g, uses 3-5 days in every 1kg feedstuff.Test is 21 days, treats according to different chicken symptom improvement situations, totally treats after 5 days, adds up cure rate, effective percentage, inefficiency and the mortality rate of ill chicken.Experimental result as shown in Table 1 and Table 2.

Treatment standard: all symptoms all disappear, appetite and spirit are all recovered normally, are recovery from illness; Breathe in smooth and easy, trachea snore not obvious, cough with asthma symptom is clearly better, and appetite and spirit are basic to be recovered, for effectively; All symptoms all do not change, even dead, for invalid; Wherein effective percentage is that recovery from illness and effective sum account for total percentage ratio.

The overall treatment of table 1 effect synopsis % after 5 days

The each experimental group treatment of table 2 was fully recovered and effective chicken and a relatively % of time in 5 days

Data from table 1 and table 2: medicine of the present invention have rapid-action, effective percentage is high, determined curative effect, safe, the advantage that has no side effect; Treat after five days simultaneously, continue to use medicine of the present invention to treat 1-3 days for effective chicken, effective chicken of embodiment group 1 and embodiment group 2 is all fully recovered, and within several days afterwards, continues to observe, and the chicken feed intake that embodiment group 1 and embodiment group 2 are fully recovered is higher than matched group; After experiment finishes, still grouping is fed to 42 ages in days and is delivered for sale, and result is added up, and in the chicken that embodiment group 1 and embodiment group were cured in 2 five days, relapse rate is respectively: 6.5% and 5.0%, and in the chicken that matched group was cured in five days, relapse rate is 36.4%.

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims

1. be used for the treatment of the medicine of chicken wind-cold type cough, it is characterized in that, described medicine comprises following raw medicinal material: the Rhizoma Pinelliae, Poria, Rhizoma Zingiberis Recens, Fructus Gleditsia, Fructus Perillae, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis, Semen Sinapis Albae, Radix Platycodonis, Extract Carnis Bovis, Semen Benincasae, Folium Perillae, Cacumen Tamaricis, Semen Armeniacae Amarum, Flos Inulae, Rhizoma Cynanchi Stauntonii, adenostemma laveniaKuntze, gray gum, Herba Centipedae, platform mushroom, Exocarpium Citrulli, Herba Schizonepetae, Ou Zeqin, Radix Saposhnikoviae and Radix Glycyrrhizae.

2. the medicine that is used for the treatment of chicken wind-cold type cough according to claim 1, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Rhizoma Pinelliae 10-20 weight portion, Poria 15-25 weight portion, Rhizoma Zingiberis Recens 10-23 weight portion, Fructus Gleditsia 10-20 weight portion, Fructus Perillae 10-18 weight portion, Pericarpium Citri Reticulatae 20-30 weight portion, Cortex Magnoliae Officinalis 10-25 weight portion, Semen Sinapis Albae 10-20 weight portion, Radix Platycodonis 10-19 weight portion, Extract Carnis Bovis 10-18 weight portion, Semen Benincasae 10-20 weight portion, Folium Perillae 10-21 weight portion, Cacumen Tamaricis 10-20 weight portion, Semen Armeniacae Amarum 10-20 weight portion, Flos Inulae 10-20 weight portion, Rhizoma Cynanchi Stauntonii 10-18 weight portion, adenostemma laveniaKuntze 10-30 weight portion, gray gum 10-25 weight portion, Herba Centipedae 10-20 weight portion, platform mushroom 10-20 weight portion, Exocarpium Citrulli 10-19 weight portion, Herba Schizonepetae 10-24 weight portion, Ou Zeqin 10-19 weight portion, Radix Saposhnikoviae 10-20 weight portion and Radix Glycyrrhizae 10-30 weight portion.

3. the medicine that is used for the treatment of chicken wind-cold type cough according to claim 1 and 2, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Rhizoma Pinelliae 13-16 weight portion, Poria 19-23 weight portion, Rhizoma Zingiberis Recens 14-21 weight portion, Fructus Gleditsia 12-17 weight portion, Fructus Perillae 12-15 weight portion, Pericarpium Citri Reticulatae 23-28 weight portion, Cortex Magnoliae Officinalis 15-25 weight portion, Semen Sinapis Albae 12-16 weight portion, Radix Platycodonis 13-19 weight portion, Extract Carnis Bovis 10-15 weight portion, Semen Benincasae 14-20 weight portion, Folium Perillae 14-19 weight portion, Cacumen Tamaricis 12-18 weight portion, Semen Armeniacae Amarum 13-17 weight portion, Flos Inulae 13-20 weight portion, Rhizoma Cynanchi Stauntonii 13-18 weight portion, adenostemma laveniaKuntze 16-25 weight portion, gray gum 13-21 weight portion, Herba Centipedae 13-20 weight portion, platform mushroom 10-16 weight portion, Exocarpium Citrulli 10-14 weight portion, Herba Schizonepetae 14-20 weight portion, Ou Zeqin 13-19 weight portion, Radix Saposhnikoviae 13-18 weight portion and Radix Glycyrrhizae 15-23 weight portion.

4. according to the medicine that is used for the treatment of chicken wind-cold type cough described in claim 1-3 any one, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: the Rhizoma Pinelliae 15 weight portions, Poria 21 weight portions, Rhizoma Zingiberis Recens 17 weight portions, Fructus Gleditsia 14 weight portions, Fructus Perillae 14 weight portions, Pericarpium Citri Reticulatae 25 weight portions, Cortex Magnoliae Officinalis 20 weight portions, Semen Sinapis Albae 14 weight portions, Radix Platycodonis 16 weight portions, Extract Carnis Bovis 13 weight portions, Semen Benincasae 16 weight portions, Folium Perillae 16 weight portions, Cacumen Tamaricis 15 weight portions, Semen Armeniacae Amarum 15 weight portions, Flos Inulae 17 weight portions, Rhizoma Cynanchi Stauntonii 14 weight portions, adenostemma laveniaKuntze 21 weight portions, gray gum 16 weight portions, Herba Centipedae 17 weight portions, platform mushroom 13 weight portions, Exocarpium Citrulli 12 weight portions, Herba Schizonepetae 17 weight portions, Ou Zeqin 16 weight portions, Radix Saposhnikoviae 15 weight portions and Radix Glycyrrhizae 17 weight portions.

5. according to the medicine that is used for the treatment of chicken wind-cold type cough described in claim 1-4 any one, it is characterized in that, described medicine also comprises: rein in the horse back, Herba tetragoniae, Rhizoma Dioscoreae, Ganoderma and Fructus Crataegi.

6. according to the medicine that is used for the treatment of chicken wind-cold type cough described in claim 1-5 any one, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: Rhizoma Pinelliae 10-20 weight portion, Poria 15-25 weight portion, Rhizoma Zingiberis Recens 10-23 weight portion, Fructus Gleditsia 10-20 weight portion, Fructus Perillae 10-18 weight portion, Pericarpium Citri Reticulatae 20-30 weight portion, Cortex Magnoliae Officinalis 10-25 weight portion, Semen Sinapis Albae 10-20 weight portion, Radix Platycodonis 10-19 weight portion, Extract Carnis Bovis 10-18 weight portion, Semen Benincasae 10-20 weight portion, Folium Perillae 10-21 weight portion, Cacumen Tamaricis 10-20 weight portion, Semen Armeniacae Amarum 10-20 weight portion, Flos Inulae 10-20 weight portion, Rhizoma Cynanchi Stauntonii 10-18 weight portion, adenostemma laveniaKuntze 10-30 weight portion, gray gum 10-25 weight portion, Herba Centipedae 10-20 weight portion, platform mushroom 10-20 weight portion, Exocarpium Citrulli 10-19 weight portion, Herba Schizonepetae 10-24 weight portion, Ou Zeqin 10-19 weight portion, Radix Saposhnikoviae 10-20 weight portion, Radix Glycyrrhizae 10-30 weight portion, the 10-20 weight portion of reining in the horse back, Herba tetragoniae 10-20 weight portion, Rhizoma Dioscoreae 15-25 weight portion, Ganoderma 15-30 weight portion and Fructus Crataegi 10-15 weight portion.

7. according to the medicine that is used for the treatment of chicken wind-cold type cough described in claim 1-6 any one, it is characterized in that, described medicine is made up of the raw medicinal material of following parts by weight: the Rhizoma Pinelliae 15 weight portions, Poria 20 weight portions, Rhizoma Zingiberis Recens 17 weight portions, Fructus Gleditsia 15 weight portions, Fructus Perillae 14 weight portions, Pericarpium Citri Reticulatae 25 weight portions, Cortex Magnoliae Officinalis 18 weight portions, Semen Sinapis Albae 15 weight portions, Radix Platycodonis 14 weight portions, Extract Carnis Bovis 14 weight portions, Semen Benincasae 15 weight portions, Folium Perillae 16 weight portions, Cacumen Tamaricis 15 weight portions, Semen Armeniacae Amarum 15 weight portions, Flos Inulae 15 weight portions, Rhizoma Cynanchi Stauntonii 14 weight portions, adenostemma laveniaKuntze 20 weight portions, gray gum 17 weight portions, Herba Centipedae 15 weight portions, platform mushroom 15 weight portions, Exocarpium Citrulli 14 weight portions, Herba Schizonepetae 17 weight portions, Ou Zeqin 14 weight portions, Radix Saposhnikoviae 15 weight portions, Radix Glycyrrhizae 20 weight portions, 15 weight portions of reining in the horse back, Herba tetragoniae 15 weight portions, Rhizoma Dioscoreae 21 weight portions, Ganoderma 21 weight portions and Fructus Crataegi 12 weight portions.

8. according to the preparation method of the medicine that is used for the treatment of chicken wind-cold type cough described in claim 1-7 any one, it is characterized in that, described preparation method comprises the following steps: