CN109260410A - A kind of improvement functional consitipation food and medicine consangunity beverage and preparation method thereof - Google Patents
A kind of improvement functional consitipation food and medicine consangunity beverage and preparation method thereof Download PDFInfo
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- CN109260410A CN109260410A CN201810201144.1A CN201810201144A CN109260410A CN 109260410 A CN109260410 A CN 109260410A CN 201810201144 A CN201810201144 A CN 201810201144A CN 109260410 A CN109260410 A CN 109260410A
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
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- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The present invention provides a kind of improvement functional consitipation food and medicine consangunity beverage, the bulk pharmaceutical chemicals of the beverage effective component are fructus cannabis, brush-cherry seed, almond, peach kernel, fructus alpiniae oxyphyllae, Semen sesami nigrum, Radix Angelicae Sinensis radish seed and nine taste medicinal material of fingered citron are made, the present invention is further directed to the preparation method of the beverage, in composition of the invention, selected bulk pharmaceutical chemicals are the Chinese medicine of food and medicine consangunity, it has no toxic side effect, using safer, each raw material reasonable recipe, compatibility science, relax bowel and defecation has been played between drug jointly, nourishing yin to moisten dryness, nourishing liver and kidney effect, with apparent synergistic effect, the compatibility relationship that mutual reinforcement between mutually makes is given full play to.Preclinical laboratory shows that the beverage can enhance mice with constipation gastrointestinal motility ability, and alleviation motor function is limited and dysporia, has the characteristics that safe without toxic side effect.
Description
Technical field
The invention belongs to integration of drinking and medicinal herbs technical field of beverage more particularly to a kind of improvement functional consitipation food and medicine consangunity beverages
And preparation method thereof.
Background technique
The main performance of constipation is that defecation frequency is reduced and difficult defecation, the defecation frequency of many patients are less than weekly 2 times,
Serious person is primary up to 2~4 weeks ability defecations or daily defecation is multiple, but difficult, excrement scleroma such as sheep dung shape is discharged, and quantity is very
It is few.In addition, have abdominal distension, anorexia, and take that cathartic is improper to cause abdominal pain etc. before defecation.
For the treatment of constipation, doctor trained in Western medicine is based on symptomatic treatment, it is intended to and the symptom for eliminating constipation keeps patient's defecation unobstructed,
Bowel frequency increases, and excrement is easy to be discharged.Common laxative has bulk cathartic, osmotic laxative treatments, dripping of irritant drugs and motivator
Agent etc., but said medicine treatment presence leads to abdominal distension, intestinal obstruction, melanosis coli, cardiovascular complication, electrolyte disturbance, kidney
The risk of the side effects such as functional lesion.
Traditional Chinese medicine treatment constipation has long history, and document is recorded and long-term clinical practice also indicates that traditional Chinese medicine anti-
The aspect that treats constipation has apparent positive effect.But by the product mesh for the improvement functional consitipation that food and medicine consangunity Chinese medicine is prepared
It is preceding on the market or blank, the highest attention with Chinese society living-pattern preservation and the people to health care, and
Country flourishes to the attention of health industry and the traditional Chinese medicine being good at dialectical diagnosis and treatment, it is necessary to which exploitation meets clinical
Property demand, improve the new product of constipation.
Number of patent application CN200710159000.6, patent name are a kind of Chinese medicine for treating constipation, and formula is (to press
Weight percent) aloe 17% ~ 36%, raw rhubarb, 26% ~ 36%, Radix Angelicae Sinensis 18% ~ 36%, Cortex Phellodendri 12% ~ 23%, it can be with by above-mentioned formula
Pill, tablet, capsule is made or decoction is made, but since formula contains raw rhubarb, is easy to cause the damage of people's healthy tendency, and pre-
While anti-and treatment constipation, some toxic side effects are also produced to organs such as liver kidneys, for Patients with Functional Constipation not
It is suitble to take for a long time.
Therefore, a kind of improvement functional consitipation food and medicine consangunity beverage and preparation method thereof is invented to be very necessary.
Summary of the invention
The object of the present invention is to provide a kind of beverages of food and medicine consangunity for improving functional consitipation, by 9 tastes " food and medicine consangunity "
Chinese medicine be prepared as a raw material, the food and medicine consangunity Chinese medicine composition have relax bowel and defecation, heat-clearing remove stagnant, nourishing yin and nourishing blood, it is simultaneous
The effect of nourishing liver and kidney, can be effectively improved constipation symptom, and safe without toxic side effect, beverage can be made, can be suitble to old age
People and other constipation patient long-term drinkings.
A kind of improvement functional consitipation food and medicine consangunity beverage, which is characterized in that the improvement functional consitipation food and medicine consangunity
Beverage includes the Chinese medicine of following weight parts:
10-20 parts of fructus cannabis, 25-35 parts of brush-cherry seed, 6-12 parts of almond, 6-12 parts of peach kernel, 6-12 parts of fructus alpiniae oxyphyllae, Semen sesami nigrum 6-12
Part, 15-25 parts of Radix Angelicae Sinensis, 15-25 parts of radish seed, 10-20 parts of fingered citron.
It is a further object of the present invention to provide the preparation method of the beverage, which may be implemented industrialized production.
Above-mentioned food and medicine consangunity Chinese medicine composition can directly crush each raw material, use after mixing；Or add water to cook use.
It is a kind of improve functional consitipation food and medicine consangunity method for preparing beverage, it is described the preparation method is as follows:
(1) fructus cannabis, Radix Angelicae Sinensis, pharmaceutical preparation auxiliary material are mixed, are added water to cook twice, add 8 times of amount water for the first time, decocted 2 hours,
Second plus 6 times of amount water, decoct 1.5 hours, merge the filtrate decocted twice, are concentrated under the conditions of temperature is 50 DEG C,
The medicinal extract that relative density is 1.2；
(2) Semen sesami nigrum and almond are crushed, sieve with 100 mesh sieve, be then uniformly mixed with above-mentioned resulting Chinese medical concrete to obtain the final product.
The pharmaceutically acceptable auxiliary material is the customary adjuvant in pharmaceutical preparation, preferably glycerol, butanediol, seaweed
One of sugar, glycine betaine, allantoin, carbomer, arginine, shea butter, jojoba oil, emulsifier are a variety of.
The third aspect of the present invention provides a kind of health care product for improving constipation, is with above-mentioned food and medicine consangunity Chinese medicine composition
Effective component.
The fourth aspect of the present invention provides a kind of special medicine purposes functional food for improving constipation, same with above-mentioned food medicine
Source Chinese medicine composition is effective component.
Compared with prior art, the invention has the following beneficial effects: in composition of the invention, selected bulk pharmaceutical chemicals
It is the Chinese medicine of food and medicine consangunity, has no toxic side effect, use is safer；Each raw material reasonable recipe, compatibility is scientific, between drug altogether
With relax bowel and defecation, nourishing yin to moisten dryness, nourishing liver and kidney effect has been played, there is apparent synergistic effect, given full play to mutual reinforcement between phase
The compatibility relationship made.
Using composition of the invention as effective component, can be prepared into pharmaceutical preparation for treating or improving constipation,
A variety of various forms of products such as health care product and special medicine purposes functional food, products application are various informative.
For the validity for proving beverage of the present invention, special open opens up following tests:
Animal experiment:
1. animal packet and model copy
Cleaning grade Kunming mouse, male, 40, weight 18-22g.After Animal adaptability is raised 7 days, random digits table is used
It is randomly divided into normal group, model group, model administration group, normal administration group, totally 4 groups, every group 10.
Mouse itself excrement is ground a little, adds physiological saline that the suspension of 0.lg/L is made, by 1mL/ only daily stomach-filling
Give 1 time, for three days on end；In the 5-7 days, daily with compound diphenoxylate solution (2mg/kg) stomach-filling, 0.3mL/ only, continuous 3
It, administration and modeling interval 30min replicate Constipation Model.
2. medicine preparation and administration
Model administration group and normal administration group apply the composition of the beverage of the food and medicine consangunity of above-mentioned improvement functional consitipation, according to
People's per weight crude drug amount acquires mouse unit weight crude drug amount, and expands 20 times, i.e. 12g/kg.
Model administration group and normal administration group animal, gastric infusion 1 time a day, 0.3mL/ only, continuous 7 days；Normal group and
Model group gives equal amount of distilled water stomach-filling, and in after the last administration, fasting 12h is put to death each group.
3. detection project
3.1 ordinary circumstance
Observe mobility, mental status, hair luster degree and the diet situation of mouse.
3.2 defecation Germicidal efficacies
The 30min after administration in the 7th day, gives groups of animals prepared 5 % active carbon suspension, this uses active carbon
Suspension is mixed using the 5 active carbon charcoal ends % and 10 % gum arabics proportion, and mouse is put into and is covered with by every 0.2mL
In the mouse cage of filter paper, every cage puts mouse 1, and normal supply word material and drinking-water, starts simultaneously at accurate timing.Observe and record every
The time of the excrement of melena containing powdered carbon is discharged in mouse for the first time, and 4h is observed continuously, and records the total defecation grain number of mouse in 4h, and weigh.
3.3 small intestine charcoal end propulsion rates
Each group is detected in after the last administration, fasting 12h forms 5% with 5% active carbon charcoal end and 10% gum arabic mixing match
Active carbon suspension, stomach-filling take off neck after every 0.2mL, 25min immediately and push away and put to death animal, open abdominal cavity rapidly, separate small intestine,
Clip upper end is placed on pallet from the intestinal tube of pylorus, lower end to ileocecus, is gently paved small intestine and is in line, and is not pulled.Measurement
Length of intestine is total small intestinal length, from pylorus to charcoal end forward position for charcoal end promote length, be calculated by formula charcoal end propulsion rate (note:
Charcoal end propulsion rate (%)=charcoal end promotes length+total small intestinal length X 100%).
3.4 gastric emptying rate
Mouse 2%DB-2000 stomach-filling, 0.4ml/ only, survey absorbance value, gastric emptying rate (%)=1- at spectrophotometer 620nm
A1/A2, wherein A1: DB-2000 absorbance value in stomach, A2: benchmark DB-2000 absorbance value.
4. result
4.1 ordinary circumstance
Normal group mouse is fat, it is spiritual it is good, action is active, diet does not subtract, fur is moist.Model group mouse see fur color without
Gloss, jaundice with hair is erected, curl squat, activity is reduced, apathetic, receive difference, excrement quality is hard, dry.Pharmaceutical intervention group
The above-mentioned change of mouse is mitigated.
4.2 defecation experimental observations
Compared with normal group, the model group small mouse's head grain melena time extends, and 4h defecation grain number, 4h defecation weight significantly reduce, poor
It is different to have significant meaning (P < 0.05 or P < 0.01).Compared with model group, the model administration group first grain melena time shortens, 4h defecation grain
Number, 4h defecation weight increase (P < 0.05).It is shown in Table 1
1 each group mouse defecation situation of table compares (n=8, x ± s)
1 each group mouse defecation situation of table compares (n=8, x ± s)
| Group | First grain melena time (min) | 4h defecation weight (g) | 4h defecation grain number |
| Normal group | 81. 875 ± 9. 300 | 0.711 ±0.212 | 36. 105 ±5. 512 |
| Model group | 119.875 ±14.618 ** | 0.258 ±0. 108 ** | 18.066±3. 808 ** |
| Model administration group | 92. 000 ± 12. 367# | 0.537±0.132# | 38 002 ± 4. 199 # |
Note: organizing ratio with normal,* P < 0.05,** P <0.01；With model group ratio,# P < 0.05,## P <0.01
The observation of 4.3 gastroenteritic power functions
Model group mouse small intestine charcoal end propulsion rate reduces, and has significant meaning (P < 0.05 or P < 0.01) mould with normal group comparing difference
Type administration group mouse small intestine charcoal end propulsion rate increases, and has compared with model group significant difference (P < 0.05 or P < 0.01), prompts energy
Enhance mice with constipation gastrointestinal motility ability, alleviation motor function is limited and dysporia.Normal group exists with normal administration group mouse
Difference is without significant property in terms of small intestine charcoal end propulsion rate.It is shown in Table 2.
The gastrointestinal function of 2 each group mouse of table compares (n=8, x ± s)
| Group | Gastric emptying rate (%) | Intestinal propulsive rate (%) |
| Normal group | 91.29±6.92 | 68.15±7.25 |
| Model group | 55.83±12.31* | 50.22±11.72* |
| Model administration group | 87.53±7.36# | 70. 490 ± 6. 43# |
Note: organizing ratio with normal,* P < 0.05,** P <0.01；With model group ratio,# P < 0.05,## P <0.01
Typical case:
Certain patient, female, 14 years old, student.Constipation, abdominal distention after meal more than 1 year.Stool a line on the 3rd~4, difficult defecation, amount are few micro- dry.
Abdominal distention after meal, easily out of strength, the multiple acne of face, when send out canker sore.Usually because study is nervous, there is mild anxiety mood.It receives
Can, poor, urine tune of sleeping.Few through measuring, light through color, menostaxis.Pink tongue, white,slippery and moist fur, weak pulse.It is checked in certain hospital within 2015 complete
Alimentary canal barium meal no abnormality seen.It is oral to give this beverage, each 30ML of morning and evening sub-service.It defecates again after 6 days l times daily, abdominal distension is obvious
Mitigate.It is advised to adjust daily life, feed rich cellulose-containing veterinary antibiotics and cereal, suitably increase activity, it is fixed to form more
When defecation habit.Follow-up is not recurred.
Specific embodiment
The present invention is described further below:
Embodiment:
The present invention provides a kind of improvement functional consitipation food and medicine consangunity beverage, which is characterized in that the beverage includes following weight parts
Chinese medicine:
10-20 parts of fructus cannabis, 25-35 parts of brush-cherry seed, 6-12 parts of almond, 6-12 parts of peach kernel, 6-12 parts of fructus alpiniae oxyphyllae, Semen sesami nigrum 6-12
Part, 15-25 parts of Radix Angelicae Sinensis, 15-25 parts of radish seed, 10-20 parts of fingered citron.
The above-mentioned beverage the preparation method is as follows:
(1) fructus cannabis, Radix Angelicae Sinensis, pharmaceutical preparation auxiliary material are mixed, are added water to cook twice, add 8 times of amount water for the first time, decocted 2 hours,
Second plus 6 times of amount water, decoct 1.5 hours, merge the filtrate decocted twice, are concentrated under the conditions of temperature is 50 DEG C,
The medicinal extract that relative density is 1.2；
(2) Semen sesami nigrum and almond are crushed, sieve with 100 mesh sieve, be then uniformly mixed with above-mentioned resulting Chinese medical concrete to obtain the final product.
The pharmaceutically acceptable auxiliary material is the customary adjuvant in pharmaceutical preparation, preferably glycerol, butanediol, seaweed
One of sugar, glycine betaine, allantoin, carbomer, arginine, shea butter, jojoba oil, emulsifier are a variety of.
The third aspect of the present invention provides a kind of health care product for improving constipation, is with above-mentioned food and medicine consangunity Chinese medicine composition
Effective component.
The fourth aspect of the present invention provides a kind of special medicine purposes functional food for improving constipation, same with above-mentioned food medicine
Source Chinese medicine composition is effective component.
Using technical solutions according to the invention or those skilled in the art under the inspiration of technical solution of the present invention,
Similar technical solution is designed, and reaches above-mentioned technical effect, is to fall into protection scope of the present invention.
Claims (3)
1. a kind of improvement functional consitipation food and medicine consangunity beverage, which is characterized in that the improvement functional consitipation food and medicine consangunity beverage
The raw material medicaments in part by weight of effective component is calculated as:
6-12 parts of almond of 25-35 parts of brush-cherry seed of 10-20 parts of fructus cannabis
6-12 parts of Semen sesami nigrum of 6-12 portions of fructus alpiniae oxyphyllae of 6-12 parts of peach kernel
10-20 parts of fingered citron of 15-25 portions of radish seed of 5-25 parts of Radix Angelicae Sinensis.
2. improving the preparation method of functional consitipation food and medicine consangunity beverage as described in claim 1, it is characterised in that this method
Are as follows:
(1) fructus cannabis, Radix Angelicae Sinensis, pharmaceutical preparation auxiliary material are mixed, are added water to cook twice, add 8 times of amount water for the first time, decocted 2 hours,
Second plus 6 times of amount water, decoct 1.5 hours, merge the filtrate decocted twice, are concentrated under the conditions of temperature is 50 DEG C,
The medicinal extract that relative density is 1.2；
(2) Semen sesami nigrum and almond are crushed, sieve with 100 mesh sieve, be then uniformly mixed with above-mentioned resulting Chinese medical concrete to obtain the final product.
3. improving the preparation method of functional consitipation food and medicine consangunity beverage as claimed in claim 2, which is characterized in that the medicine
Object pharmaceutical adjunct be glycerol, butanediol, trehalose, glycine betaine, allantoin, carbomer, arginine, shea butter, jojoba oil,
One of emulsifier is a variety of.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112641877A (en) * | 2019-10-10 | 2021-04-13 | 王忠民 | Medicine for quickly treating constipation |
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| CN102526410A (en) * | 2012-02-23 | 2012-07-04 | 许从玉 | Medicinal composition for treating functional constipation |
| CN106038820A (en) * | 2016-06-30 | 2016-10-26 | 王季馨 | Edible and medicinal traditional Chinese medicine composition for improving functional constipation and preparation method thereof |
| CN106473099A (en) * | 2016-10-12 | 2017-03-08 | 钟术光 | Functional food or alternative tea that effect improves |
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2018
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|---|---|---|---|---|
| CN102526410A (en) * | 2012-02-23 | 2012-07-04 | 许从玉 | Medicinal composition for treating functional constipation |
| CN106038820A (en) * | 2016-06-30 | 2016-10-26 | 王季馨 | Edible and medicinal traditional Chinese medicine composition for improving functional constipation and preparation method thereof |
| CN106473099A (en) * | 2016-10-12 | 2017-03-08 | 钟术光 | Functional food or alternative tea that effect improves |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112641877A (en) * | 2019-10-10 | 2021-04-13 | 王忠民 | Medicine for quickly treating constipation |
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Application publication date: 20190125 |