CN112641877A

CN112641877A - Medicine for quickly treating constipation

Info

Publication number: CN112641877A
Application number: CN201911004427.8A
Authority: CN
Inventors: 王忠民
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-10-10
Filing date: 2019-10-10
Publication date: 2021-04-13

Abstract

The invention discloses a medicine for quickly treating constipation, which is prepared by taking bunge cherry seed, fructus cannabis, radish seed, almond, perilla seed, black fungus, rhizoma polygonati, Chinese date, angelica and cistanche as raw materials according to a certain weight ratio. The medicament can be prepared into any common oral dosage form, has the functions of benefiting qi and nourishing blood, strengthening spleen and benefiting lung, relaxing bowel, strengthening physique and the like, treats constipation, dyspepsia, weak physique, limb weakness and the like caused by dysfunction, has particularly quick response, obvious effect, no toxic or side effect and wide application range, and comprises all people including the old, pregnant women, children and the like.

Description

Medicine for quickly treating constipation

Technical Field

The invention relates to a medicine for quickly treating constipation, in particular to a medicine which is prepared by taking plant traditional Chinese medicines which are both edible and medicinal as raw materials according to a certain weight ratio and is used for treating chronic functional constipation and a series of discomfort symptoms caused by the chronic functional constipation.

Background

Constipation is a common and frequently encountered disease. Clinical research shows that the prevalence rate of constipation of old people in China is 18.1%, the prevalence rate of constipation of children is 18.8%, and the prevalence rate is obviously higher than 8.2% of that of general people. If the middle-aged people and the elderly are counted together, about 40 percent of people in China suffer from constipation with different degrees; while in foreign countries 45-50% of people suffer from constipation. Severe constipation affects the normal life of the patient, and is especially important for timely treatment because constipation is also a manifestation of the disease.

The main clinical manifestations of constipation are a reduced number of stools, dry and hard stools and/or difficulty in defecation. Generally, the defecation frequency of a patient is reduced, the defecation is less than 3 times per week, the defecation is laborious, difficult to discharge and incomplete, the anorectal obstruction/blockage is caused when the defecation is expensive, and a manual auxiliary defecation is required when the defecation is serious.

The constipation is caused by a plurality of reasons, the general condition is poor, the physical exercise is reduced, the psychopsychological stress is too large, the life rhythm is accelerated, the cellulose or coarse food grain is too little to take, and the constipation caused by taking some medicaments (such as opium medicaments, psychotropic medicaments, antispasmodics, anticholinergics, calcium channel antagonists, dopaminergic medicaments, non-steroidal anti-inflammatory medicaments, bile acid binding medicaments, calcium agents, iron agents and the like) are common factors. These factors are often unavoidable.

Constipation is not only difficult defecation, but more serious constipation may be followed by a series of diseases. Long-term constipation can cause hemorrhoids, emotional disorder and sleep disorder, can stimulate malignant Parkinson's disease syndrome, can aggravate or induce cardiovascular diseases, even can cause sudden death, and seriously affects physical and psychological health of patients.

At present, the number of medicines for effectively treating constipation in the market is quite large, and the number of Chinese medicines and western medicines is large. However, constipation is not simply difficult to relieve constipation, and is often caused by dysfunction of the zang-fu organs, qi and blood, and it is the treatment method that the function of the zang-fu organs is restored by conditioning the zang-fu organs and qi and blood and relaxing the bowels at the same time, so that the circulation of qi and blood is normal. On the one hand, the traditional Chinese medicine accumulates abundant clinical experience for treating constipation, for example, the decoction guide method of honey is established in Shang Han Lun, and the recorded fructus cannabis pills are still widely used clinically so far, and obtain better curative effect.

However, some Chinese patent medicines have a limited range of application and safety because of many causes of constipation. At present, a special traditional Chinese medicine for treating constipation, which is efficient, safe, quick and free of toxic and side effects, is clinically lacked. Researches and develops a medicine which effectively prevents constipation, regulates qi and blood functions of viscera, is safe and reliable, has no toxic or side effect, can be taken for a long time, and is particularly important for a large number of constipation patients.

The invention provides a medicament which has reliable curative effect without toxic or side effect, has obvious effect of comprehensively treating constipation and simultaneously regulates qi and blood of viscera, particularly develops the medicament with obvious curative effect by using medicine-food dual-purpose traditional Chinese medicines, has the characteristics of safety and effectiveness, has very important practical significance, and is the starting point and the research purpose of an inventor. The successful development of a Chinese medicinal preparation for quickly treating constipation fills the blank that a Chinese medicinal preparation used as both medicine and food can quickly and effectively treat constipation.

Disclosure of Invention

A medicine for quickly treating constipation is prepared from the Chinese-medicinal materials including liquorice root, etc through supplementing qi, nourishing blood, invigorating spleen, benefiting lung, relaxing bowels, and strengthening physique.

The location of constipation is in the large intestine and is closely related to the zang-fu organs, including the lung, spleen, liver and kidney. Constipation is the disorder of conduction, mainly caused by the obstruction of qi movement, the failure of the circulation of qi, and the obstruction and blockage of the intestines. Constipation can occur when lung qi fails to disperse and descend, liver qi stagnation and spleen fails to transport and transport, and the stagnation of qi in stomach and intestine can lead to heat accumulation and fluid impairment, heat in large intestine can cause accumulation of dry feces, and obstruction of qi in fu-organs can cause constipation. The pathogenesis is actually the result of the combined action of multiple factors.

The treatment of TCM mainly follows the principle that the treatment should be based on the root cause. Chronic functional constipation has long disease course and weak constitution, is mostly suitable for middle-aged and elderly people with poor physical conditions, postpartum women, weak children and other people, and is accompanied by viscera dysfunction, deficiency of qi and blood and other pulse symptoms, so when treating the constipation, the constipation is relieved, more importantly, the causes of the constipation are removed, the constipation is fundamentally treated, and the functions of normal viscera, qi and blood and the like are recovered.

The doctor of the department of traditional Chinese medicine inheritance studio and the master and ren traditional Chinese medical doctors, Wangzhong, in Tianjin, have been exploring for many years and believe that the constipation is caused by the dysfunction of viscera, which belongs to the root cause of constipation, and once the intestines are blocked, the constipation can occur. Constipation is treated simply by constipation, and the suspicion of treating headache, foot pain and foot is provided. The key point of treatment is to take the effect of conditioning viscera and simultaneously taking the symptoms into consideration, so as to treat both symptoms and root causes, and to quickly smoothen the intestines and the bowels and relieve constipation.

The medicine is realized by the following technical scheme. The medicine for quickly treating constipation is characterized by being prepared from the following raw materials in parts by weight by a conventional process of Chinese materia medica pharmaceutics: 10-60 parts of bunge cherry seed, 10-55 parts of fructus cannabis, 10-60 parts of radish seed, 10-50 parts of almond, 10-45 parts of perilla seed, 10-45 parts of black fungus, 10-55 parts of rhizoma polygonati, 10-50 parts of Chinese date, 10-60 parts of angelica and 10-60 parts of cistanche.

The raw material medicaments and the dosage formula are obtained by the inventor through combined clinical tests of many medical institutions for many years, and have obvious curative effect within the dosage range.

The Chinese medicine composition for quickly curing constipation is prepared by using Chinese dwarf cherry seed, fructus cannabis, radish seed, almond, perilla seed, black fungus, polygonatum root, jujube, Chinese angelica root and cistanche to make compatibility, and the functions of all the medicines produce mutual synergistic action, so that it has the functions of supplementing qi and nourishing blood, strengthening spleen and tonifying lung, moistening intestines and relaxing bowels and can raise physique to induce constipation, and its clinical observation proves that it has obvious effect.

The medicine for quickly treating constipation is sweet, smooth and convenient, can guide qi stagnation in large intestine and lubricate dryness and astringency of large intestine, and has obvious function of promoting intestinal peristalsis and good function on constipation caused by various factors; huo Ma ren has the action of moistening intestines to relieve constipation, and is mainly used for treating constipation due to blood deficiency and body fluid deficiency and intestinal dryness. Belongs to a nourishing and dryness-moistening traditional Chinese medicine, has the functions of reducing blood fat, resisting aging, resisting oxidation, reducing blood pressure, improving learning and memory and the like, and is mainly used for tonifying middle-jiao and Qi and is not as old as in Shen nong Ben Cao Jing (Shen nong's herbal classic); the radish seed has the effects of depressing qi, relieving flatulence, promoting digestion, relaxing bowels, reducing phlegm, relieving cough, strengthening gastrointestinal tract power, lowering blood pressure, reducing blood fat, resisting cancer, removing toxic substances, and the like; the almond has the effects of relieving cough and reducing sputum, clearing heat and moistening lung, relaxing bowels and prolonging life, beautifying and losing weight, and nourishing brain and developing intelligence, and has the effects of resisting oxidation, resisting thrombus, resisting tumor, reducing blood fat, detoxifying and the like; fructus Perillae has effects of lowering qi, eliminating phlegm, relieving cough and asthma, loosening bowel to relieve constipation, resisting oxidation, resisting aging, resisting tumor, resisting arteriosclerosis, resisting depression, and reducing blood sugar; auricularia has effects of invigorating spleen, replenishing qi, invigorating spleen, nourishing kidney, moistening dryness, relaxing bowels, and harmonizing five internal organs, and has effects of reducing blood lipid, lowering blood sugar, resisting oxidation, resisting aging, resisting tumor, resisting blood coagulation, resisting virus, resisting bacteria, and enhancing immunity; rhizoma Polygonati has effects of invigorating spleen and kidney, moistening lung, promoting fluid production, loosening bowel to relieve constipation, resisting aging, resisting tumor, resisting inflammation, resisting virus, reducing blood sugar, reducing blood lipid, preventing atherosclerosis, improving memory, and regulating immunity; the Chinese date has the effects of tonifying middle-jiao and Qi, nourishing blood and soothing nerves, and has the effects of resisting oxidation, aging and tumor, promoting immunologic function, improving gastrointestinal environment and relaxing the bowels; the angelica has the effects of tonifying blood, regulating blood, moistening dryness and relaxing bowels, and has multiple functions of resisting oxidation, resisting aging, resisting coagulation, resisting inflammation, resisting injury, enhancing immunity and the like; cistanche deserticola has the effects of tonifying kidney and strengthening yang, replenishing essence and marrow, nourishing blood and prolonging life, moistening dryness and relaxing bowels, has the effects of resisting oxidation, aging and fatigue, and the like, can improve intestinal peristalsis, inhibit water absorption of large intestine, shorten defecation time, and has good effect on body deficiency and constipation.

A medicine for quickly treating constipation has the functions of relieving constipation symptom and its symptom caused by constipation, and promoting health of patient. The medicines used in the formula are not the superposition of the effects of single traditional Chinese medicines, but are scientifically prepared on the basis of the treatment based on syndrome differentiation of the traditional Chinese medicine, and the formula effect of 1+1 being larger than 2 is realized. The traditional Chinese medicine is mainly embodied in a plurality of efficacies of benefiting qi and nourishing blood, strengthening spleen and benefiting lung, relaxing bowel, strengthening physique and the like.

Moreover, the pharmacological actions of the medicines have related pharmacological research or animal test conclusions.

The medicine can be prepared into oral administration dosage forms by adopting a conventional method of Chinese medicine preparations. The medicine of the invention can be prepared by grinding the raw materials into powder and uniformly mixing the powder into powder, granules, oral liquid and beverage. The active ingredients can be obtained by decocting the raw materials in water and then concentrating the decoction, and then the active ingredients can be prepared into various oral preparations, but the invention is not limited by the active ingredients.

The medicine can also be used for extracting effective components by adopting methods such as semi-bionic extraction (SBE), Supercritical Fluid Extraction (SFE), microwave extraction (MAE), enzyme extraction (ETE), ultrasonic extraction (UAE), semi-bionic extraction (SEB), squeezing extraction (PE), Continuous Countercurrent Extraction (CCE), tissue disruption extraction (STE), heating-free extraction (HFE), normal-temperature ultrahigh-pressure extraction (U HPE), Air Explosion Extraction (AEE) and the like, and the extraction methods are all in the protection range of the medicine.

The following capsule formulations are preferred for use in the present invention.

The preparation method of the medicine comprises the following steps:

(1) weighing the raw materials in proportion for later use;

(2) 10 traditional Chinese medicines of the bunge cherry seed, the fructus cannabis, the radish seed, the almond, the perilla seed, the black fungus, the rhizoma polygonati, the Chinese date, the angelica and the cistanche in the weight ratio are delivered to a professional traditional Chinese medicine pharmaceutical factory for extraction after being checked and accepted;

(3) extracting by a pharmaceutical factory according to a conventional method and a conventional program for extracting traditional Chinese medicines;

(4) packaging the extracted medicinal powder into bottled capsules, wherein each bottle contains 60 capsules, and each capsule contains 0.45g of the Chinese medicinal extract powder;

(5) or making the extracted medicine into granules, wherein each bag contains 6g of traditional Chinese medicine extraction powder;

(6) the finished product is delivered to clinical trials by the pharmaceutical factory.

The clinical use results show that the medicine of the invention has the following advantages:

1. the invention selects natural edible plant medicines as raw materials, and each component accords with the regulation of a pharmaceutical law and the principle of a traditional Chinese medicine prescription, and highlights the basic characteristics of the combination of traditional Chinese medicine syndrome differentiation and western medicine disease differentiation and the combination of etiology treatment and symptomatic treatment;

2. the medicine of the invention does not need to be decocted after being extracted, has good taste and convenient taking, is nontoxic and harmless before and after the prescription of each medicine, and has no side effect after being taken with normal dosage;

3. the medicine has good treatment effect on a plurality of symptoms caused by constipation and dyspepsia, has good prevention and health care effects, and has wide application range;

4. the medicine is selected from varieties which can be used as both medicine and food and are specified in Wei Jian Wei, has higher safety, and can be taken for a long time for treating patients with middle-aged and weak constitution and limb weakness;

5. the medicine has good compatibility, and has certain compatibility of treatment on the symptoms such as complication, low immunity, sub-health and the like which are easy to appear in patients;

6. the application range is wide, and the medicine composition comprises all people such as the old, pregnant women and children;

7. the medicine of the invention treats both principal and secondary aspect of disease, and has quick effect.

Detailed Description

The effect of the present invention will be further illustrated by the following examples and clinical application statistics.

Example 1: capsule preparation

15kg of bunge cherry seed, 20kg of fructus cannabis, 20kg of radish seed, 20kg of almond, 15kg of perilla seed, 15kg of black fungus, 20kg of rhizoma polygonati, 20kg of Chinese date, 15kg of angelica and 20kg of cistanche, are extracted and processed by a professional Chinese medicine pharmacy factory, and are prepared into capsules, wherein each capsule is 0.45g, 4 capsules each time and 3 times a day.

Example 2: beverage preparation

15kg of bunge cherry seed, 20kg of fructus cannabis, 20kg of radish seed, 20kg of almond, 15kg of perilla seed, 15kg of black fungus, 20kg of rhizoma polygonati, 20kg of Chinese date, 15kg of angelica and 20kg of cistanche, are extracted and processed by a professional Chinese medicine pharmacy factory, are prepared into granules, 6g of the granules is prepared into 1 bag per time, and the granules are taken with water 3 times a day.

Clinical observation of the drug of the invention

One, general data

In order to prove the clinical curative effect of the medicine, in 6 months to 5 months of 2019 in 2018, 132 cases of male and female constipation patients are treated by the traditional Chinese medicine outpatient service, wherein the patients are 20 to 75 years old and mean (39 +/-11.2) years old; 58 men and 74 women; the shortest disease course is 6 months, the longest disease course is 6 months in 3 years, and the average disease course (31 +/-12.9) months; the groups were divided into observation group and control group 2 by digital random table method, 66 cases each. The general clinical data of 2 groups of age, sex, course of disease, etc. have no significant difference through statistical treatment and are comparable (P > 0.05).

And (3) inclusion standard: referring to 2006 international standard for functional gastrointestinal disease roman iii (rome iii), the following conditions are provided: the diagnosis standard of Rome III is met, the disease course of constipation is more than 6 months, and symptom attack occurs in the last 3 months; constipation patients aged > 20 years < 75 years; patients volunteered to participate in clinical treatment and signed consent.

Exclusion criteria: those who have been administered the drug or therapy associated with the treatment of the disease within 2 weeks prior to treatment; patients with intestinal organic diseases through examination by an electronic colonoscope and the like; allergic constitution and people allergic to various drugs; patients with essential diseases such as cardiovascular disease, cerebrovascular disease, liver disease, kidney disease, hemopoietic system, etc., and malignant tumor; pregnant and lactating women; the patient is not suitable for selection according to the judgment of the researcher.

Second, test method

Comparison medication: the observation group takes the medicinal granules of the invention with 6g per bag, 1 bag per time and 3 times per day after being taken with water; the control group orally administered fructus Cannabis soft capsule (produced by Tianjin Central pharmaceutical industry) 2 capsules each time, 2 times daily. All the drugs related to the disease are stopped taking in the 2 groups of treatment periods, and the 2 groups of treatment periods are continuously taken for 2 weeks.

And (3) observing items: with reference to a functional constipation symptom scoring method established by the perianal and intestinal science group of the scientific division of the Chinese medical society, namely the Changchun constipation academic conference 2005, the anus obstruction feeling, the incomplete defecation feeling, the defecation laboriousness degree, the defecation time each time, the defecation frequency and the excrement shape of 2 groups of patients after 2 weeks of treatment are scored.

Grading standard: the defecation frequency, the defecation time each time and the excrement character are judged according to the obstruction feeling of the defecation anus, the incomplete defecation feeling, the defecation labor intensity. 0 minute: respectively is asymptomatic, natural defecation, 1-2 d/time, 1-10 min and Bristol grade 4-7; 1 minute: the patient feels tolerant and slight, needs to defecate slightly with strength, 3 d/time, 10-15 min and Bristol grade 3; and 2, dividing: the symptoms obviously interfere with normal life, are obvious, require obvious force to defecate, are 4-5 d/time, 15-25 min and are Bristol grade 2; and 3, dividing: severe symptoms and influence life and work, intolerable and hard defecation need to be assisted by other methods, more than 5 d/time, more than 25min and Bristol grade 1.

The curative effect standard is as follows: the method is formulated according to the institute of Chinese medicine, the medical department of the Chinese medical science, the institute of spleen and stomach diseases, the professional Committee of the institute of gastroenterology of traditional Chinese medicine, the practical traditional Chinese medicine and the institute of Liu Bao Hua, the diagnosis and treatment of constipation. Efficacy index ═ (pre-treatment score-post-treatment score)/pre-treatment score × 100%. The symptom disappears, the stool is normal, the symptom score is more than or equal to 95 percent, and the clinical recovery is kept for more than 2 weeks; the symptoms are obviously improved, and the integral of the symptoms is more than or equal to 70 percent and less than 95 percent, so the effect is obvious; the symptom is improved, and the integral of the symptom is more than or equal to 30 percent and less than 70 percent, which is effective; no improvement in symptoms, and an integration of symptoms < 30% was found to be ineffective.

Statistical analysis: statistical analysis is carried out by adopting SPSS10.0 for windows statistical software, and x is adopted for comparing the two groups of curative effects²The test shows that P is less than 0.05, which shows that the difference is statistical.

Comparison of symptom scores before and after treatment: after 2 weeks of medication, the symptom score of the patients in the group 2 is obviously reduced compared with that before treatment, the difference has statistical significance, and P is less than 0.05. Compared with the control group, the observation group has better effect than the control group on the integral improvement of defecation labor intensity, defecation time, excrement character and the like, and P is less than 0.05.

Follow-up conditions: after 1 month after treatment, the observation group finishes the follow-up visit of 62 patients and 60 patients in the control group through the outpatient service or telephone follow-up visit. The observation group is completely cured by 16 cases (25.81%), obviously effective by 25 cases (40.32%), effectively effective by 17 cases (27.42%), ineffective by 4 cases (6.45%), and the total effective rate is 93.55%; the control group is cured by 2 cases (3.33%), obvious effect 13 cases (21.67%), effective 28 cases (46.67%), ineffective 17 cases (28.33%) and total effective rate 71.67%. The total effective rate of the 2 groups after 1 month of treatment has significant difference, and P is less than 0.05. The medicine has obvious effect on treating constipation and has certain clinical popularization value.

Claims

1. The formula of the medicine for quickly treating constipation is characterized in that the medicine is prepared from medicine and food dual-purpose traditional Chinese medicines according to the following parts by weight of raw material medicines:

2. the medicament for rapidly treating constipation according to claim 1, wherein the formulation is prepared into capsules by a conventional process of Chinese materia medica pharmaceutics.

3. The medicine for rapidly treating constipation according to claim 1, wherein the formula is characterized in that the medicine is prepared into tablets by adopting the conventional process of Chinese materia medica pharmaceutics.

4. The medicine for rapidly treating constipation according to claim 1, wherein the formula is characterized in that the medicine is prepared into powder or granules by adopting the conventional process of Chinese materia medica pharmaceutics.

5. The medicament for rapidly treating constipation according to claim 1, wherein the medicament is formulated into water pills, honey pills, water honey pills, concentrated pills or dripping pills by a conventional process of Chinese medicinal preparations.

6. The medicine for rapidly treating constipation according to claim 1, wherein the formula is characterized in that the oral liquid is prepared by a conventional process of Chinese materia medica pharmaceutics.

7. The medicine for rapidly treating constipation according to claim 1, wherein the formula is characterized in that the medicine is prepared into tea by a conventional process of Chinese materia medica pharmaceutics.