CN104721784A - Blood circulation-activating and stasis-removing preparation for breast tumour and preparation method - Google Patents

Abstract

The invention discloses a blood circulation-activating and stasis-removing preparation for breast tumour. The blood circulation-activating and stasis-removing preparation for breast tumour is prepared from the following main raw materials in parts by weight: 8-12 parts of kelp, 9-16 parts of radix scrophulariae, 5-10 parts of poria cocos, 8-16 parts of rhizoma sparganii, 9-15 parts of curcuma zedoary, 9-15 parts of trichosanthes kirilowii maxim, 9-15 parts of radix asparagi, 10-20 parts of bamboo shavings, 10-20 parts of baked ginger, 8-12 parts of stellaria yunnanensis, 9-12 parts of starwort, 5-10 parts of Chinese fan palm, 9-16 parts of pokeberry root, 8-16 parts of eleusine indica, 10-20 parts of nodus nelumbinis rhizomatis, and 8-12 parts of cuttle bone. The blood circulation-activating and stasis-removing preparation for breast tumour has the effects of soothing liver and regulating qi, activating blood circulation and removing stasis, activating collaterals and inducing resuscitation, and relieving swelling and pain, has an obvious curative effect on the breast tumour, and is free from any side effect and adverse reaction.

Description

Breast tumor blood circulation promoting and blood stasis dispelling preparation and preparation method

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to a kind of breast tumor blood circulation promoting and blood stasis dispelling preparation and preparation method.

Background technology

The many no conscious symptons of breast tumor, lump be often patient inadvertently (as having a bath, changing one's clothes) find.A few patients can have tenderness in various degree or stimulation and nipple discharge.The speed of growth of lump is very fast, invades and surrounding tissue can cause the change of mammary contour, occurs a series of sign.As: tumor surface skin depressions, nipple can lead to cancerous protuberance direction by the cancerous protuberance of contiguous nipple, retracted nipple etc.Cancerous protuberance the greater, whole breast tissue can be made to shrink, and lump obviously protrudes.Cancerous protuberance continues to increase, and forms so-called Pericarpium Citri Reticulatae sample and changes.These are all the important symptoms of breast tumor.

Early stage breast tumor mostly occurs at the first half of breast, accounts for more than 50%, wherein again with outside upper quadrant morbidity at most, more relevant with breast outside upper gland leaf.Early stage breast tumor originates from glandular tube epithelium, and cancer in situ is difficult to find.Also have a kind of rare breast carcinoma to be invisible breast carcinoma, in its breast, lump can not find, but has occurred that oxter is shifted.The Symptoms of early stage breast tumor: 1. lump: patient is to find in breast that lump clients accounts for the overwhelming majority, and breast carcinoma mostly is single, multiple focus in few visible same breast.Lump morphological differences is comparatively large, and it is generally acknowledged that form is irregular, blur margin is clear, and quality is partially hard.Carcinous lump is limited in mammary gland essence in early days, still can promote, but does not have larger mobility like that like benign tumor, once invade fascia or skin, lump just can not promote, and stadium also belongs to more late.2. pain: most patient is without obvious pain perception, and small number of patients is gone to a doctor with pain, and pain mostly is paroxysmal twinge, dull pain.3. nipple discharge: nipple liquid can be physiological or pathologic, the nipple discharge incidence rate of non-pregnant age of sucking is about 3%-8%, and discharge can be colourless, milky, faint yellow, brown, courageous and upright etc., also can be water sample, blood sample, serosity sample pus; Discharge amount is the amount doesn't matter, and interval time is also different, should carry out smear cells check with clearly nipple discharge.Breast carcinoma is most with mammary gland tumor, is merely that symptom is rare with nipple discharge.4. skin of breast changes: breast carcinoma skin change and the tumor position depth are with to invade degree relevant.Lump is little, and position is dark, and how unchanged skin is, and lump is large, and position is shallow, comparatively early with skin adhesion, makes skin present depression, dimple sign.If cancerous cell blocks subcutaneous lymphatic vessel cause hydroderma, form orange peel and become, belong to Late manifestations.5. nipple changes: normal person's bilateral breast is symmetrical, has cancerous protuberance to exist near nipple, nipple often by lead, therefore bilateral nipple just differs.Retracted nipple is the vital sign of breast center cancerous protuberance, and nipple is difficult to involve with finger, and nipple is in fixing retracted state.Eczematoid carcinoma is then shown in that nipple is rotten to the corn shape, often has crust skin; Diseased region and skin are demarcated fully aware of, and diseased region and skin are demarcated fully aware of, and affected skin is thicker.

At present, the medicine for the treatment of breast tumor exists, for the problems referred to above, a kind of cyclomastopathy tumor that patent document discloses of publication number CN 104225098 A (application number 201310239886.0) disappears, its Chinese medicine ingredients and dosage are: Stigma Croci 100 grams, 80 grams, Cornu Cervi Pantotrichum, Radix Notoginseng 80 grams, Squama Manis 80 grams, king do not stay 80 grams, above-mentioned compatibility dosage is immersed in high spirit, soak and get wine liquid after 30 days and repeatedly rub patient affected part alleviating pain immediately, Reusability can eradicate slight illness.Publication number CN 103816325 A(application number 201310154020.X) patent document discloses a kind of Chinese medicine preparation early stage for breast carcinoma, manufacture method: take Radix Angelicae Sinensis 200g, Radix Paeoniae Alba (parched) 200g, Radix Ginseng 200g, Radix Astragali 200g, Rhizoma Chuanxiong 100g, Radix Saposhnikoviae 100g, Fructus Perillae 100g, Radix Angelicae Dahuricae 100g, Fructus Aurantii 100g, Radix Platycodonis 100g, Radix Glycyrrhizae 100g, Semen Arecae 100g, Radix Linderae 100g, Cortex Magnoliae Officinalis 100g, Cortex Cinnamomi 80g, Caulis Akebiae 80g, above-mentioned raw materials wine is washed, dry, mild and heavy respiration decocts 60 minutes, filter worm, second time decocts 30 minutes, filter, merging filtrate, add food antiseptics (3%), enter container store and get final product, Radix Aucklandiae 300g, Pericarpium Citri Reticulatae Viride 300g powder are become sublimed preparation, adding Matrii Sulfas Exsiccatus 250g with honey is the external of cream deposit.Publication number CN 102697973 A(application number 201210136406.3) patent document discloses a kind of newborn Kang An sachet, provide a kind of using several precious Chinese herbal medicine: the derivant of the form that chemically can accept of the combined extracts such as Herba Houttuyniae, flying apsaras sieve Wield, calabash any of several broadleaf plants, wild Ganoderma, Lignum Aquilariae Resinatum, Catalpa or extract is prepared into the medicine such as powder or granule as main component or pharmaceutically acceptable physical aspect makes newborn Kang An sachet.

Current doctor trained in Western medicine take excision as first-selection, and combination with radiotherapeutic, chemotherapy, endocrine therapy and immunotherapy etc., and operative treatment is comparatively large to body injury, and can only for observable cancer cell, helpless to invisible cancerous cell.Chemicotherapy can heavy damage normal immunity, and make the body immunity of patient, lower for the resistance, along with the decline of immunity, resistance, the transfer diffusion velocity of cancerous cell can be faster, and have larger toxic and side effects after radiotherapy in the treatment.

Summary of the invention

For the deficiencies in the prior art, an object of the present invention is to provide a kind of breast tumor blood circulation promoting and blood stasis dispelling preparation, has depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, dredging collateral of having one's ideas straightened out, effect of reducing swelling and alleviating pain, obvious curative effect is had to breast tumor, and without any side effects and untoward reaction.Another object of the present invention is just to provide the preparation method of above-mentioned breast tumor blood circulation promoting and blood stasis dispelling preparation.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

Breast tumor blood circulation promoting and blood stasis dispelling preparation, takes off the primary raw material stating weight proportion and is prepared from: Thallus Laminariae (Thallus Eckloniae) 8-12 part; Radix Scrophulariae 9-16 part; Poria 5-10 part; Rhizoma Sparganii 8-16 part; Rhizoma Curcumae 9-15 part; Fructus Trichosanthis 9-15 part; Radix Asparagi 9-15 part; Caulis Bambusae In Taenia 10-20 part; Rhizoma Zingiberis Preparatum 10-20 part; Radix Stellariae Yunnanensis 8-12 part; Herba stellariae mediae 9-12 part; Chinese fanpalm seed 5-10 part; Radix Phytolaccae 9-16 part; Herba Eleusines Indicae 8-16 part; Nodus Nelumbinis Rhizomatis 10-20 part; Os Sepiae 8-12 part.

Breast tumor blood circulation promoting and blood stasis dispelling preparation, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Thallus Laminariae (Thallus Eckloniae) 9-11 part; Radix Scrophulariae 11-13 part; Poria 6-9 part; Rhizoma Sparganii 11-13 part; Rhizoma Curcumae 11-13 part; Fructus Trichosanthis 11-13 part; Radix Asparagi 11-13 part; Caulis Bambusae In Taenia 13-17 part; Rhizoma Zingiberis Preparatum 13-17 part; Radix Stellariae Yunnanensis 9-11 part; Herba stellariae mediae 10-11 part; Chinese fanpalm seed 6-9 part; Radix Phytolaccae 11-13 part; Herba Eleusines Indicae 11-13 part; Nodus Nelumbinis Rhizomatis 13-17 part; Os Sepiae 9-11 part.

Breast tumor blood circulation promoting and blood stasis dispelling preparation, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from :thallus Laminariae (Thallus Eckloniae) 10 parts; Radix Scrophulariae 12 parts; 8 parts, Poria; Rhizoma Sparganii 12 parts; Rhizoma Curcumae 12 parts; Fructus Trichosanthis 12 parts; Radix Asparagi 12 parts; Caulis Bambusae In Taenia 15 parts; Rhizoma Zingiberis Preparatum 15 parts; Radix Stellariae Yunnanensis 10 parts; Herba stellariae mediae 10.5 parts; Chinese fanpalm seed 8 parts; Radix Phytolaccae 12 parts; Herba Eleusines Indicae 12 parts; Nodus Nelumbinis Rhizomatis 16 parts; Os Sepiae 10 parts.

Present invention also offers the preparation method above-mentioned breast tumor blood circulation promoting and blood stasis dispelling preparation being made pharmaceutically acceptable powder, decoction, capsule, pill and tablet.

The preparation method of described breast tumor blood circulation promoting and blood stasis dispelling preparation powder, step is as follows:

(1) cleaned by Nodus Nelumbinis Rhizomatis, be placed in stone mortar and smash to pieces, wear into Rhizoma Nelumbinis slurry, pulp washing, rinsing, precipitation, drains, and take out, dry in the sun 2-3 hour, chips powder ball with cutter, dries, and smashes;

(2) Os Sepiae is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) Poria, Fructus Trichosanthis and Chinese fanpalm seed are placed in frying pan, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), dry in the air cool, be ground into fine powder altogether, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);

(4) Tumble Dry Thallus Laminariae (Thallus Eckloniae), Radix Scrophulariae, Rhizoma Sparganii, Rhizoma Curcumae, Radix Asparagi, Caulis Bambusae In Taenia, Rhizoma Zingiberis Preparatum, Radix Stellariae Yunnanensis, Herba stellariae mediae, Radix Phytolaccae and Herba Eleusines Indicae (preferable temperature 80-90 DEG C, be more preferably temperature 85 DEG C), be placed in pulverizer to pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);

(5) by step (1)-(4) gained fine powder mix homogeneously, sterile packaged is carried out by pharmaceutically accepted specification.

Instructions of taking: at every turn get 8-10g, is placed in tea bag, soaks, every day 2-3 time, 10 days courses for the treatment of by the warm waters of about 50 DEG C.

The preparation method of described breast tumor blood circulation promoting and blood stasis dispelling preparation decoction, step is as follows:

(1) cleaned by Nodus Nelumbinis Rhizomatis, be placed in stone mortar and smash to pieces, wear into Rhizoma Nelumbinis slurry, pulp washing, rinsing, precipitation, drains, and take out, dry in the sun 2-3 hour, chips powder ball with cutter; Continue to dry, smash;

(2) Os Sepiae is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) Poria, Fructus Trichosanthis and Chinese fanpalm seed are placed in frying pan, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), and spray rice vinegar, flood intense fire fried dry after 3-5 minute, taking-up is dried in the air cool;

(4) Radix Scrophulariae, Rhizoma Sparganii, Rhizoma Curcumae, Radix Asparagi, Caulis Bambusae In Taenia, Radix Stellariae Yunnanensis and Radix Phytolaccae are placed in marmite, soak half an hour, intense fire is boiled, turn slow fire boiling 30-50 minute (preferably turn slow fire boiling 35-45 minute, be more preferably and turn slow fire boiling 40 minutes), add step (3) gains, Thallus Laminariae (Thallus Eckloniae), Rhizoma Zingiberis Preparatum, Herba stellariae mediae and Herba Eleusines Indicae, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;

(5) step (1)-(2) gains are joined in step (4) gained filtrate, mixing, filter, be concentrated into 1/2 of original volume, sterile packaged, obtain decoction.

Instructions of taking: each 15-20ml, with the warm water delivery service of about 35 DEG C, every day 2-3 time, 10 days courses for the treatment of.

The preparation method of described breast tumor blood circulation promoting and blood stasis dispelling preparation capsule, step is as follows:

(1) cleaned by Nodus Nelumbinis Rhizomatis, be placed in stone mortar and smash to pieces, wear into Rhizoma Nelumbinis slurry, pulp washing, rinsing, precipitation, drains, and take out, dry in the sun 2-3 hour, chips powder ball with cutter; Continue to dry, smash;

(2) Os Sepiae is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) Poria, Fructus Trichosanthis and Chinese fanpalm seed are placed in frying pan, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), and spray rice vinegar, flood intense fire fried dry after 3-5 minute, taking-up is dried in the air cool;

(4) Radix Scrophulariae, Rhizoma Sparganii, Rhizoma Curcumae, Radix Asparagi, Caulis Bambusae In Taenia, Radix Stellariae Yunnanensis and Radix Phytolaccae are placed in marmite, soak half an hour, intense fire is boiled, turn slow fire boiling 30-50 minute (preferably turn slow fire boiling 35-45 minute, be more preferably and turn slow fire boiling 40 minutes), add step (3) gains, Thallus Laminariae (Thallus Eckloniae), Rhizoma Zingiberis Preparatum, Herba stellariae mediae and Herba Eleusines Indicae, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;

(5) join in step (4) gained filtrate by step (1)-(2) gains, mixing, is condensed into the thick paste that relative density is 1.10-1.20, be modulated into the soft material that light pressure is then loose, cross 80-120 mesh sieve (preferred 90-110 mesh sieve, is more preferably 100 mesh sieves), dry, pulverize, obtain medicated powder;

(6) step (5) gained medicated powder is made capsule (preferably by the specification of 0.5g/ grain) by the specification of 0.4g-0.6g/ grain.

The preparation method of above-mentioned breast tumor blood circulation promoting and blood stasis dispelling preparation capsule, step (5) is preferably condensed into the thick paste that relative density is 1.13-1.17, is more preferably and is condensed into the thick paste that relative density is 1.15.

Instructions of taking: at every turn get 2-3 grain, every day 3 times, 10 days courses for the treatment of.

The preparation method of described breast tumor blood circulation promoting and blood stasis dispelling preparation pill, step is as follows:

(1) cleaned by Nodus Nelumbinis Rhizomatis, be placed in stone mortar and smash to pieces, wear into Rhizoma Nelumbinis slurry, pulp washing, rinsing, precipitation, drains, and take out, dry in the sun 2-3 hour, chips powder ball with cutter; Continue to dry, smash;

(2) Os Sepiae is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) Poria, Fructus Trichosanthis and Chinese fanpalm seed are placed in frying pan, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), and spray rice vinegar, flood intense fire fried dry after 3-5 minute, taking-up is dried in the air cool;

(4) Radix Scrophulariae, Rhizoma Sparganii, Rhizoma Curcumae, Radix Asparagi, Caulis Bambusae In Taenia, Radix Stellariae Yunnanensis and Radix Phytolaccae are placed in marmite, soak half an hour, intense fire is boiled, turn slow fire boiling 30-50 minute (preferably turn slow fire boiling 35-45 minute, be more preferably and turn slow fire boiling 40 minutes), add step (3) gains, Thallus Laminariae (Thallus Eckloniae), Rhizoma Zingiberis Preparatum, Herba stellariae mediae and Herba Eleusines Indicae, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;

(5) step (1)-(2) gains are joined in step (4) gained filtrate, mixing, be condensed into the thick paste that relative density is 1.10-1.30 and (be preferably condensed into the thick paste that relative density is 1.15-1.25, be more preferably and be condensed into the thick paste that relative density is 1.20), be modulated into the soft material that light pressure is then loose, cross 80-120 mesh sieve (preferred 90-110 mesh sieve, be more preferably 100 mesh sieves), dry, pulverize, obtain medicated powder;

(6) Mel is placed in pot, slow fire is tempered to thick, mixes step (5) gained medicated powder, fully mixes into ointment thoroughly, pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm) is made by traditional Chinese medical science tradition pill method.

The preparation method of above-mentioned breast tumor blood circulation promoting and blood stasis dispelling preparation pill, the consumption of the preferred Mel of step (6) is the 30%-40% of medicated powder quality, and the consumption being more preferably Mel is 35% of medicated powder quality.

Instructions of taking: each 10-15 ball, every day 3 times, 10 days courses for the treatment of.

The preparation method of described breast tumor blood circulation promoting and blood stasis dispelling formulation tablet, step is as follows:

(1) cleaned by Nodus Nelumbinis Rhizomatis, be placed in stone mortar and smash to pieces, wear into Rhizoma Nelumbinis slurry, pulp washing, rinsing, precipitation, drains, and take out, dry in the sun 2-3 hour, chips powder ball with cutter; Continue to dry, smash;

(2) Os Sepiae is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) Poria, Fructus Trichosanthis and Chinese fanpalm seed are placed in frying pan, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), and spray rice vinegar, flood intense fire fried dry after 3-5 minute, taking-up is dried in the air cool;

(4) Radix Scrophulariae, Rhizoma Sparganii, Rhizoma Curcumae, Radix Asparagi, Caulis Bambusae In Taenia, Radix Stellariae Yunnanensis and Radix Phytolaccae are placed in marmite, soak half an hour, intense fire is boiled, turn slow fire boiling 30-50 minute (preferably turn slow fire boiling 35-45 minute, be more preferably and turn slow fire boiling 40 minutes), add step (3) gains, Thallus Laminariae (Thallus Eckloniae), Rhizoma Zingiberis Preparatum, Herba stellariae mediae and Herba Eleusines Indicae, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;

(5) step (1)-(2) gains are joined in step (4) gained filtrate, mixing, be condensed into the thick paste that relative density is 1.10-1.30 and (be preferably condensed into the thick paste that relative density is 1.15-1.25, be more preferably and be condensed into the thick paste that relative density is 1.20), with fashion of extrusion by 18-26 eye mesh screen (preferred 20-24 eye mesh screen excessively, was more preferably 22 eye mesh screens), make single-size, drying, is pressed into lamellar, sugar coating.

Instructions of taking: each 2-3 sheet, every day 3 times, 10 days courses for the treatment of.

Technical advantage of the present invention is mainly reflected in:

1, breast tumor blood circulation promoting and blood stasis dispelling preparation of the present invention is based on the principle of Chinese traditional treatment breast tumor, and each raw material effect is worked in coordination with, and all medicine compatibilities, bring out the best in each other, and make the treatment of breast tumor reach treating both the principal and secondary aspects of a disease.

2, can suppress rapidly, kill and wound, killing off tumor cells, thus it is different softening and reduce that cancerous protuberance was had in the short time (in 3-7 days).

3, invention formulation is evident in efficacy, take 3-5 the course for the treatment of stable disease, control cancerous protuberance diffusion, transfer, progressively disappear, part lump and cancerous protuberance can disappear completely.

4, this breast tumor blood circulation promoting and blood stasis dispelling preparation selected materials great majority are Chinese medicine material, and medical material medicine source is easy to get, with low cost, can not bring large financial burden to patient.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.

embodiment 1breast tumor blood circulation promoting and blood stasis dispelling preparation, takes off the primary raw material stating weight proportion and is prepared from (getting 40g for every part): Thallus Laminariae (Thallus Eckloniae) 8 parts; Radix Scrophulariae 9 parts; 5 parts, Poria; Rhizoma Sparganii 8 parts; Rhizoma Curcumae 9 parts; Fructus Trichosanthis 9 parts; Radix Asparagi 9 parts; Caulis Bambusae In Taenia 10 parts; Rhizoma Zingiberis Preparatum 10 parts; Radix Stellariae Yunnanensis 8 parts; Herba stellariae mediae 9 parts; Chinese fanpalm seed 5 parts; Radix Phytolaccae 9 parts; Herba Eleusines Indicae 8 parts; Nodus Nelumbinis Rhizomatis 10 parts; Os Sepiae 8 parts.

The preparation method of above-mentioned breast tumor blood circulation promoting and blood stasis dispelling preparation powder, step is as follows:

(1) cleaned by Nodus Nelumbinis Rhizomatis, be placed in stone mortar and smash to pieces, wear into Rhizoma Nelumbinis slurry, pulp washing, rinsing, precipitation, drains, and take out, dry in the sun 2 hours, chips powder ball with cutter, dry, smash;

(2) smashed by Os Sepiae, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder sunk as above method repeatable operation 2 times, discards impurity, merges suspension, leaves standstill 3 hours, the clear water inclined above, gets precipitation and dries, porphyrize, crosses 140 mesh sieves;

(3) Poria, Fructus Trichosanthis and Chinese fanpalm seed are placed in frying pan, moderate heat fries 25 minutes, dries in the air cool, is ground into fine powder altogether, crosses 160 mesh sieves;

(4) Tumble Dry Thallus Laminariae (Thallus Eckloniae), Radix Scrophulariae, Rhizoma Sparganii, Rhizoma Curcumae, Radix Asparagi, Caulis Bambusae In Taenia, Rhizoma Zingiberis Preparatum, Radix Stellariae Yunnanensis, Herba stellariae mediae, Radix Phytolaccae and Herba Eleusines Indicae (temperature 85 DEG C), is placed in pulverizer and pulverizes, and crosses 160 mesh sieves;

(5) by step (1)-(4) gained fine powder mix homogeneously, sterile packaged is carried out by pharmaceutically accepted specification.

Instructions of taking: at every turn get 10g, is placed in tea bag, soaks, every day 3 times, 10 days courses for the treatment of by the warm waters of about 50 DEG C.

embodiment 2breast tumor blood circulation promoting and blood stasis dispelling preparation, takes off the primary raw material stating weight proportion and is prepared from (every part of 10g): Thallus Laminariae (Thallus Eckloniae) 12 parts; Radix Scrophulariae 16 parts; 10 parts, Poria; Rhizoma Sparganii 16 parts; Rhizoma Curcumae 15 parts; Fructus Trichosanthis 15 parts; Radix Asparagi 15 parts; Caulis Bambusae In Taenia 20 parts; Rhizoma Zingiberis Preparatum 20 parts; Radix Stellariae Yunnanensis 12 parts; Herba stellariae mediae 12 parts; Chinese fanpalm seed 10 parts; Radix Phytolaccae 16 parts; Herba Eleusines Indicae 16 parts; Nodus Nelumbinis Rhizomatis 20 parts; Os Sepiae 12 parts.

The preparation method of above-mentioned breast tumor blood circulation promoting and blood stasis dispelling preparation decoction, step is as follows:

(1) cleaned by Nodus Nelumbinis Rhizomatis, be placed in stone mortar and smash to pieces, wear into Rhizoma Nelumbinis slurry, pulp washing, rinsing, precipitation, drains, and take out, dry in the sun 3 hours, chips powder ball with cutter; Continue to dry, smash;

(2) smashed by Os Sepiae, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder sunk as above method repeatable operation 3 times, discards impurity, merges suspension, leaves standstill 3 hours, the clear water inclined above, gets precipitation and dries, porphyrize, crosses 140 mesh sieves;

(3) Poria, Fructus Trichosanthis and Chinese fanpalm seed are placed in frying pan, moderate heat fries 25 minutes, sprays rice vinegar, floods intense fire fried dry after 4 minutes, and taking-up is dried in the air cool;

(4) Radix Scrophulariae, Rhizoma Sparganii, Rhizoma Curcumae, Radix Asparagi, Caulis Bambusae In Taenia, Radix Stellariae Yunnanensis and Radix Phytolaccae are placed in marmite, soak half an hour, intense fire is boiled, turn slow fire boiling 40 minutes, add step (3) gains, Thallus Laminariae (Thallus Eckloniae), Rhizoma Zingiberis Preparatum, Herba stellariae mediae and Herba Eleusines Indicae, decoct twice, boil 35 minutes at every turn, twice filtrate merges;

(5) step (1)-(2) gains are joined in step (4) gained filtrate, mixing, filter, be concentrated into 1/2 of original volume, sterile packaged, obtain decoction.

Instructions of taking: each 20ml, every day 3 times, 10 days courses for the treatment of.

model case oneqiu XX, female, 49 years old, people from Juancheng County, Heze city of Shandong province.The left breast that stumbled on before 1 year has a lump, at that time without any discomfort sense, does not draw attention, until comparatively front obviously increase of conscious lump is just recognized.Once use western medical treatment, take the photograph the prompting of molybdenum target sheet: the outside upper quadrant mass of left breast is suspected to have and cancerates; B ultrasonic is pointed out: left breast homogeneity lump, has the possibility that cancerates.Since idiopathy, without chest pain and cough, without nipple discharge and courageous and upright secretions.Invalid after corresponding treatment, lump still increases gradually, and left breast is outside upper resembles protuberance, and skin has slightly " Pericarpium Citri Reticulatae sample ", has no limitation depression.Above left nipple inclined left, have no retracted nipple, two breast without red and swollen, rotten to the corn, chap and superficial vein expansion.The outside upper quadrant of left breast can touch the lump of 0.7*0.6*0.6cm, and matter is partially hard, and surface owes smooth, obscure boundary.Adhesion slight with skin, movable not good enough.

After taking 2 courses for the treatment of of gained breast tumor blood circulation promoting and blood stasis dispelling preparation decoction (embodiment 2) of the present invention, lump obviously reduces, and the outside upper quadrant of left breast can touch the lump of 0.3*0.2*0.2cm.So continue to take 2 courses for the treatment of, the basic cancellation of lump, tracing observation, fully recovers, and symptom is without recurrence.

embodiment 3breast tumor blood circulation promoting and blood stasis dispelling preparation, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part): Thallus Laminariae (Thallus Eckloniae) 9 parts; Radix Scrophulariae 11 parts; 6 parts, Poria; Rhizoma Sparganii 11 parts; Rhizoma Curcumae 11 parts; Fructus Trichosanthis 11 parts; Radix Asparagi 11 parts; Caulis Bambusae In Taenia 13 parts; Rhizoma Zingiberis Preparatum 13 parts; Radix Stellariae Yunnanensis 9 parts; Herba stellariae mediae 10 parts; Chinese fanpalm seed 6 parts; Radix Phytolaccae 11 parts; Herba Eleusines Indicae 11 parts; Nodus Nelumbinis Rhizomatis 13 parts; Os Sepiae 9 parts.

The preparation method of above-mentioned breast tumor blood circulation promoting and blood stasis dispelling preparation capsule, step is as follows:

(1) cleaned by Nodus Nelumbinis Rhizomatis, be placed in stone mortar and smash to pieces, wear into Rhizoma Nelumbinis slurry, pulp washing, rinsing, precipitation, drains, and take out, dry in the sun 3 hours, chips powder ball with cutter; Continue to dry, smash;

(2) smashed by Os Sepiae, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder sunk as above method repeatable operation 2 times, discards impurity, merges suspension, leaves standstill 3 hours, the clear water inclined above, gets precipitation and dries, porphyrize, crosses 140 mesh sieves;

(3) Poria, Fructus Trichosanthis and Chinese fanpalm seed are placed in frying pan, moderate heat fries 25 minutes, sprays rice vinegar, floods intense fire fried dry after 4 minutes, and taking-up is dried in the air cool;

(4) Radix Scrophulariae, Rhizoma Sparganii, Rhizoma Curcumae, Radix Asparagi, Caulis Bambusae In Taenia, Radix Stellariae Yunnanensis and Radix Phytolaccae are placed in marmite, soak half an hour, intense fire is boiled, turn slow fire boiling 40 minutes, add step (3) gains, Thallus Laminariae (Thallus Eckloniae), Rhizoma Zingiberis Preparatum, Herba stellariae mediae and Herba Eleusines Indicae, decoct twice, boil 35 minutes at every turn, twice filtrate merges;

(5) join in step (4) gained filtrate by step (1)-(2) gains, mixing, is condensed into the thick paste that relative density is 1.15, is modulated into the soft material that light pressure is then loose, crosses 100 mesh sieves, dry, pulverize, obtain medicated powder;

(6) step (5) gained medicated powder is made capsule by the specification of 0.5g/ grain.

Instructions of taking: each 2-3 grain, every day 3 times, 10 days courses for the treatment of.

embodiment 4breast tumor blood circulation promoting and blood stasis dispelling preparation, takes off the primary raw material stating weight proportion and is prepared from (getting 15g for every part): Thallus Laminariae (Thallus Eckloniae) 9 parts; Radix Scrophulariae 11 parts; 6 parts, Poria; Rhizoma Sparganii 11 parts; Rhizoma Curcumae 11 parts; Fructus Trichosanthis 11 parts; Radix Asparagi 11 parts; Caulis Bambusae In Taenia 13 parts; Rhizoma Zingiberis Preparatum 13 parts; Radix Stellariae Yunnanensis 9 parts; Herba stellariae mediae 10 parts; Chinese fanpalm seed 6 parts; Radix Phytolaccae 11 parts; Herba Eleusines Indicae 11 parts; Nodus Nelumbinis Rhizomatis 13 parts; Os Sepiae 9 parts.

The preparation method of above-mentioned breast tumor blood circulation promoting and blood stasis dispelling preparation pill, step is as follows:

(1) cleaned by Nodus Nelumbinis Rhizomatis, be placed in stone mortar and smash to pieces, wear into Rhizoma Nelumbinis slurry, pulp washing, rinsing, precipitation, drains, and take out, dry in the sun 3 hours, chips powder ball with cutter; Continue to dry, smash;

(2) smashed by Os Sepiae, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder sunk as above method repeatable operation 2 times, discards impurity, merges suspension, leaves standstill 3 hours, the clear water inclined above, gets precipitation and dries, porphyrize, crosses 140 mesh sieves;

(3) Poria, Fructus Trichosanthis and Chinese fanpalm seed are placed in frying pan, moderate heat fries 25 minutes, sprays rice vinegar, floods intense fire fried dry after 4 minutes, and taking-up is dried in the air cool;

(4) Radix Scrophulariae, Rhizoma Sparganii, Rhizoma Curcumae, Radix Asparagi, Caulis Bambusae In Taenia, Radix Stellariae Yunnanensis and Radix Phytolaccae are placed in marmite, soak half an hour, intense fire is boiled, turn slow fire boiling 40 minutes, add step (3) gains, Thallus Laminariae (Thallus Eckloniae), Rhizoma Zingiberis Preparatum, Herba stellariae mediae and Herba Eleusines Indicae, decoct twice, boil 35 minutes at every turn, twice filtrate merges;

(5) join in step (4) gained filtrate by step (1)-(2) gains, mixing, is condensed into the thick paste that relative density is 1.20, is modulated into the soft material that light pressure is then loose, crosses 100 mesh sieves, dry, pulverize, obtain medicated powder;

(6) be placed in pot by Mel (consumption is 35% of medicated powder quality), slow fire is tempered to thick, mixes step (5) gained medicated powder, fully mixes into ointment thoroughly, makes by the traditional Chinese medical science tradition pill method pill that diameter is 4mm.

Instructions of taking: each 10 balls, every day 3 times, 10 days courses for the treatment of.

model case twosoviet Union XX, female, 59 years old, people from Gaotang County, Liaocheng of Shandong Province.Retired worker, gives birth to youngster one female.The left breast that stumbled on when once having a bath before 2 years has the lump of a small broad bean size, painless, movable, and Progressive symmetric erythrokeratodermia increases.Once repeatedly invalid in hospitalize, lump obviously increases.Patient is without trauma history, and without nipple discharge, nothing is obviously become thin, skin, sclera without xanthochromia, the discovery without exception of the heart, lung, left breast is slightly less than right breast, the outer top of nipple deflection, outside upper quadrant has slightly " Pericarpium Citri Reticulatae sample " to change, and can touch the lump of 0.6*0.5*0.5cm, and matter is hard, obscure boundary, with skin adhesion, movable not good enough, without tenderness.Left oxter can be laid one's hand on and the lymph node of many pieces of enlargements, and matter is hard, without tenderness, merges without adhesion, activity still can, surperficial deficient smooth, obscure boundary.Molybdenum target and B ultrasonic are all pointed out at the outside upper quadrant mass of breast, are diagnosed as left newborn breast tumor.

After taking 2 courses for the treatment of of gained breast tumor blood circulation promoting and blood stasis dispelling preparation pill (embodiment 4) of the present invention, symptom obviously alleviates, and the comparatively small lymph node cancellation of left oxter, larger lymph node also obviously reduces, and the lump on left breast also obviously reduces.So continue to take 2 courses for the treatment of, the lymph node substantially all cancellation of left oxter, goes examination in hospital to find tumor cancellation substantially, does not continue development.Later stage follows up a case by regular visits to and learns and fully recover.

embodiment 5breast tumor blood circulation promoting and blood stasis dispelling preparation, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Thallus Laminariae (Thallus Eckloniae) 10 parts; Radix Scrophulariae 12 parts; 8 parts, Poria; Rhizoma Sparganii 12 parts; Rhizoma Curcumae 12 parts; Fructus Trichosanthis 12 parts; Radix Asparagi 12 parts; Caulis Bambusae In Taenia 15 parts; Rhizoma Zingiberis Preparatum 15 parts; Radix Stellariae Yunnanensis 10 parts; Herba stellariae mediae 10.5 parts; Chinese fanpalm seed 8 parts; Radix Phytolaccae 12 parts; Herba Eleusines Indicae 12 parts; Nodus Nelumbinis Rhizomatis 16 parts; Os Sepiae 10 parts.

The preparation method of above-mentioned breast tumor blood circulation promoting and blood stasis dispelling formulation tablet, step is as follows:

(1) cleaned by Nodus Nelumbinis Rhizomatis, be placed in stone mortar and smash to pieces, wear into Rhizoma Nelumbinis slurry, pulp washing, rinsing, precipitation, drains, and take out, dry in the sun 3 hours, chips powder ball with cutter; Continue to dry, smash;

(2) smashed by Os Sepiae, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder sunk as above method repeatable operation 3 times, discards impurity, merges suspension, leaves standstill 3 hours, the clear water inclined above, gets precipitation and dries, porphyrize, crosses 140 mesh sieves;

(3) Poria, Fructus Trichosanthis and Chinese fanpalm seed are placed in frying pan, moderate heat fries 25 minutes, sprays rice vinegar, floods intense fire fried dry after 4 minutes, and taking-up is dried in the air cool;

(4) Radix Scrophulariae, Rhizoma Sparganii, Rhizoma Curcumae, Radix Asparagi, Caulis Bambusae In Taenia, Radix Stellariae Yunnanensis and Radix Phytolaccae are placed in marmite, soak half an hour, intense fire is boiled, turn slow fire boiling 40 minutes, add step (3) gains, Thallus Laminariae (Thallus Eckloniae), Rhizoma Zingiberis Preparatum, Herba stellariae mediae and Herba Eleusines Indicae, decoct twice, boil 35 minutes at every turn, twice filtrate merges;

(5) join in step (4) gained filtrate by step (1)-(2) gains, mixing, is condensed into the thick paste that relative density is 1.20, with fashion of extrusion by 22 eye mesh screens, makes single-size, dry, is pressed into lamellar, sugar coating.

Instructions of taking: each 2-3 sheet, every day 3 times, 10 days courses for the treatment of.

The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:

Thallus Laminariae (Thallus Eckloniae): salty in the mouth, cold in nature.Return liver, stomach, kidney channel.For the dry thallus of Laminariaceae plant Thallus Laminariae (Thallus Eckloniae) or Alariaceae plant Thallus Laminariae (Thallus Eckloniae).There is hard masses softening and resolving, expectorant, effect of diuretic.For wart cancer, scrofula, painful and swollen testis, phlegm retention edema.

Radix Scrophulariae: bitter in the mouth, salty, cold nature.For the root of Scrophulariaceae herbaceos perennial Radix Scrophulariae.There is clearing away heat and cooling blood, replenishing YIN and removing heat, effect of eliminating fire and detoxication.For excessive thirst of having a fever, spontaneous sweating, haematemesis nose bleeding, pharyngolaryngitis, pulmonary tuberculosis, epidemic febrile disease sends out speckle, the pharyngalgia of pyretic toxicity Sheng, conjunctival congestion, ear swells, consumption of YIN caused by febrile disease, crimson tongue excessive thirst, maculae caused by violent heat pathogen, and constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough, diphtheria, fidgets due to deficiency is awake not, and order is puckery dim-sighted, laryngopharynx swelling and pain, scrofula sucutaneous nodule, skin sore.

Poria: sweet in the mouth, light, property is put down.GUIXIN, lung, spleen, kidney channel.For the dry sclerotia of On Polyporaceae Poria.Have promoting diuresis to eliminate damp pathogen, invigorating the spleen for dissipating phlegm, mind tranquilizing and the heart calming, relieve internal heat anticancer effect.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia, dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, and malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.

Rhizoma Sparganii: acrid in the mouth, hardship, property is put down.Return liver, spleen channel.For the dry tuber of Sparganiaceae plant rhizoma scirpi.There is removing blood stasis circulation of qi promoting, effect of removing food stagnancy pain relieving.Yong Yu Disorder trace mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain.

Rhizoma Curcumae: acrid in the mouth, hardship, warm in nature.Return liver, spleen channel.For the dry rhizome of zingiberaceous plant Rhizoma Curcumae, Guangxi zedoary or RADIX CURCUMAE.There is circulation of qi promoting removing blood stasis, effect of removing food stagnancy pain relieving.Yong Yu mass in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain, early cervical carcinoma.

Fructus Trichosanthis: sweet in the mouth, bitter in the mouth, cold in nature.Return lung, stomach, large intestine channel.For the mature fruit of Cucurbitaceae herbaceous perennial vine Trichosanthes kirilowii or trichosanthes rosthornii Harms.Fructus Trichosanthis master is containing triterpene saponin.The fatty oil of seed, saponin.Pericarpium Trichosanthis is containing several amino acids and alkaloid etc.Peel contains three circle Saponins, organic acid, resin, saccharide and pigment.The fatty oil of seed about 26%.There is removing heat-phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, effect of loosening bowel to relieve constipation.For phlegm-heat cough, lung abscess vomiting pus, thoracic obstruction hypochondriac pain, blocked-up chest, acute mastitis, dryness of the intestine constipation etc.

Radix Asparagi: sweet in the mouth, bitter in the mouth, cold in nature.For the tuber of liliaceous plant Radix Asparagi.There is YIN nourishing, moisturize, lung heat clearing, effect of pathogenic fire reducing.For fever due to yin deficiency, cough is spitted blood, and consumptive lung disease, lung abscess, laryngopharynx swelling and pain, quenches one's thirst, constipation.

Caulis Bambusae In Taenia: sweet in the mouth, cold in nature.Attach to the lung and stomach meridians.For the dry intermediate layer of the stem stalk of grass bambusa breviflora Munro, major part allusion quotation bamboo or phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle.There is removing heat-phlegm, the effect relieved restlessness and prevented vomiting.For phlegm-heat cough, expectorant held under the arm by gallbladder fire, and dysphoria with smothery sensation is vomitted, palpitation with fear insomnia, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement.

Rhizoma Zingiberis Preparatum: acrid in the mouth, hot in nature.Return board, stomach, kidney, the heart, lung meridian.For the Preparation process product of Rhizoma Zingiberis.There is warming spleen and stomach for dispelling cold, effect of warming the meridian for stopping bleeding.For Deficiency and coldness of spleen and stomach, stomachache is vomited and diarrhoea, and tell rule metrorrhagia, yang deficiency is lost blood.

Radix Stellariae Yunnanensis: sweet in the mouth, property is put down.For the root of pinkwort Yunnan Herba stellariae mediae.There is strong board, nourishing the liver, effect of kidney tonifying.For the empty anemia of body, spirit is deficient, dizzy nervous, tinnitus dim eyesight, hectic fever, seminal emission, lumbago flaccidity of the lower limbs, and menoxenia, leukorrhagia drenches drop, infantile malnutrition.

Herba stellariae mediae: sweet in the mouth, acid, cool in nature.For Caryophyllaceae Stellaria plant Herba stellariae mediae, with all herbal medicine.Herb is containing Saponin 4.5%, and main ruscogenin is gypsogenin, again containing flavones ingredient: orientin, isorientin, vitexin, isovitexin, luteolin etc.There is heat-clearing and toxic substances removing, blood-activating analgetic, effect of lactogenic.For enteritis, dysentery, hepatitis, appendicitis, postnatal blood stasis is suffered from abdominal pain, uterine contraction pain, toothache, early whitening of hair, agalactia, mastitis, traumatic injury, sore swollen toxin.

Chinese fanpalm seed: sweet in the mouth, hardship, property is put down.For the seed of babassu Semen livistonae chinensis.Containing phenols, reducing sugar, tannin, triacylglycerol, aminoacid: lysine, serine, arginine, proline, tyrosine, valine, isoleucine, phenylalanine, sugar, vitamin C, the oil of shell and kernel is mainly containing oleic acid.There is blood circulation promoting and blood stasis dispelling, effect of hard masses softening and resolving.For chronic hepatitis, lump in the abdomen, metrorrhagia, traumatic hemorrhage, cancer.

Radix Phytolaccae: bitter in the mouth, cold in nature, poisonous.Return lung, spleen, kidney, large intestine channel.For the dry root of Phytolaccaceae plant pokeweed or pokeroot.There is detumescence of relieving oedema or abdominal distension through diuresis or purgation, smoothening secretion, effect of detoxicating and resolving stagnation of pathogens.For edema distension, constipation and anuresis; External treatment carbuncle sore tumefacting virus.

Herba Eleusines Indicae: sweet in the mouth, light, property is put down.Return liver, stomach two warp.For the herb of grass family yard grass platymiscium Herba Eleusines Indicae.Containing isorientin, luteolin-7-O-rutinoside, tricin, luteolin-7-O-glycoside, special Jing Su, isovitexin.There is heat-clearing and toxic substances removing, expelling wind and removing dampness, effect of dissipating blood stasis hemostasis.For preventing and treating epidemic encephalitis type B, epidemic cerebrospinal meningitis, rheumatic arthritis, icterohepatitis, infantile dyspepsia, enteritis, dysentery, urethritis; Traumatic injury is controlled in external, traumatic hemorrhage, dog bite.

Nodus Nelumbinis Rhizomatis: sweet in the mouth, puckery, property is put down.Return liver, lung, stomach warp.For the dry root stipes portion of nymphaeaceae plant lotus.There is hemostasis, effect of repercussive, for spitting blood, spitting of blood, epistaxis, hematuria, metrorrhagia.

Os Sepiae: salty in the mouth, puckery, warm in nature.Return spleen, kidney channel.For the dry inner shell of Sepiidae animal sepiella maindroni de Rochebrune or golden cuttlefish.Containing calcium carbonate more than 85%, in addition, containing methionine, aspartic acid, glutamic acid etc.There is astringing to arrest bleeding, relieving leukorrhea by astringents, antacid, effect of sore.For Peptic Ulcers, hyperchlorhydria, hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge, stomachache acid regurgitation; External treatment bleeding due to trauma, the many pus of skin ulcer.

test examplein order to verify the curative effect of gained breast tumor blood circulation promoting and blood stasis dispelling preparation (embodiment 5) of the present invention, do contrast test in July ,-2011 in June, 2009:

General data: screen 200 routine Breast Tumor Patients in Duo Jia hospital, wherein minimal ages 31 years old, max age 67 years old, 49.4 years old mean age; 31-40 year 36 people, 41-50 year 96 people, 51-67 year 68 people.Be divided into experimental group and matched group two groups (wherein experimental group 150 people, matched group 50 people) at random, two groups are compared there was no significant difference (P > 0.05), have comparability in sex, age, the course of disease, state of an illness scoring etc.

Diagnostic criteria: nipple discharge; Nipple and mammary areola change; Local skin changes; Breast contours changes; Axillary fossa and supraclavicular fossa lymph node etc.

Usage and dosage: experimental group takes gained breast tumor blood circulation promoting and blood stasis dispelling formulation tablet of the present invention, each 2, every day 3 times, 10 days courses for the treatment of; Matched group takes other medicine (as PINGXIAO JIA0NANG, Traditional Chinese medicinal liquid for eliminating module in breast etc.), wherein, and PINGXIAO JIA0NANG: oral, a 4-8 grain, 3 times on the one; Traditional Chinese medicinal liquid for eliminating module in breast: oral, a 10ml, 2 times on the one, shakes up when taking.

Criterion of therapeutical effect: cure: after 4 courses for the treatment of of medication, lump in breast disappears, and malaise symptoms disappears.Effective: after 4 courses for the treatment of of medication, lump in breast obviously reduces, and malaise symptoms is obviously alleviated.Invalid: after 4 courses for the treatment of of medication, symptom is unchanged.

4 courses for the treatment of of medication treatment, observe latter 1 year for the treatment of.The Comparison of therapeutic of the matched group adopting other drug and the experimental group taking gained breast tumor blood circulation promoting and blood stasis dispelling preparation of the present invention, result is as shown in table 1:

Table 1

As can be seen from Table 1, take the cure rate of gained breast tumor blood circulation promoting and blood stasis dispelling preparation of the present invention up to 77.33%, effective percentage is up to 97.33%; And the cure rate taking other drug only 42%, effective percentage also only has 78%, and inefficiency is up to 22%.Can find out: the successful taking gained breast tumor blood circulation promoting and blood stasis dispelling preparation of the present invention is better than taking the effect of other drug.

It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or obtain undoubtedly according to the written description of file, the claimed scope of this patent all should be thought.

Claims (10)

1. breast tumor blood circulation promoting and blood stasis dispelling preparation, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Thallus Laminariae (Thallus Eckloniae) 8-12 part; Radix Scrophulariae 9-16 part; Poria 5-10 part; Rhizoma Sparganii 8-16 part; Rhizoma Curcumae 9-15 part; Fructus Trichosanthis 9-15 part; Radix Asparagi 9-15 part; Caulis Bambusae In Taenia 10-20 part; Rhizoma Zingiberis Preparatum 10-20 part; Radix Stellariae Yunnanensis 8-12 part; Herba stellariae mediae 9-12 part; Chinese fanpalm seed 5-10 part; Radix Phytolaccae 9-16 part; Herba Eleusines Indicae 8-16 part; Nodus Nelumbinis Rhizomatis 10-20 part; Os Sepiae 8-12 part.

2. breast tumor blood circulation promoting and blood stasis dispelling preparation according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Thallus Laminariae (Thallus Eckloniae) 9-11 part; Radix Scrophulariae 11-13 part; Poria 6-9 part; Rhizoma Sparganii 11-13 part; Rhizoma Curcumae 11-13 part; Fructus Trichosanthis 11-13 part; Radix Asparagi 11-13 part; Caulis Bambusae In Taenia 13-17 part; Rhizoma Zingiberis Preparatum 13-17 part; Radix Stellariae Yunnanensis 9-11 part; Herba stellariae mediae 10-11 part; Chinese fanpalm seed 6-9 part; Radix Phytolaccae 11-13 part; Herba Eleusines Indicae 11-13 part; Nodus Nelumbinis Rhizomatis 13-17 part; Os Sepiae 9-11 part.

3. breast tumor blood circulation promoting and blood stasis dispelling preparation according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Thallus Laminariae (Thallus Eckloniae) 10 parts; Radix Scrophulariae 12 parts; 8 parts, Poria; Rhizoma Sparganii 12 parts; Rhizoma Curcumae 12 parts; Fructus Trichosanthis 12 parts; Radix Asparagi 12 parts; Caulis Bambusae In Taenia 15 parts; Rhizoma Zingiberis Preparatum 15 parts; Radix Stellariae Yunnanensis 10 parts; Herba stellariae mediae 10.5 parts; Chinese fanpalm seed 8 parts; Radix Phytolaccae 12 parts; Herba Eleusines Indicae 12 parts; Nodus Nelumbinis Rhizomatis 16 parts; Os Sepiae 10 parts.

4., according to the arbitrary described breast tumor blood circulation promoting and blood stasis dispelling preparation of claim 1-3, it is characterized in that, the preparation method of described powder, step is as follows:

(1) cleaned by Nodus Nelumbinis Rhizomatis, be placed in stone mortar and smash to pieces, wear into Rhizoma Nelumbinis slurry, pulp washing, rinsing, precipitation, drains, and take out, dry in the sun 2-3 hour, chips powder ball with cutter, dries, and smashes;

(2) Os Sepiae is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) Poria, Fructus Trichosanthis and Chinese fanpalm seed are placed in frying pan, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), dry in the air cool, be ground into fine powder altogether, excessively 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);

(4) Tumble Dry Thallus Laminariae (Thallus Eckloniae), Radix Scrophulariae, Rhizoma Sparganii, Rhizoma Curcumae, Radix Asparagi, Caulis Bambusae In Taenia, Rhizoma Zingiberis Preparatum, Radix Stellariae Yunnanensis, Herba stellariae mediae, Radix Phytolaccae and Herba Eleusines Indicae (preferable temperature 80-90 DEG C, be more preferably temperature 85 DEG C), be placed in pulverizer to pulverize, cross 140-180 mesh sieve (preferred 150-170 mesh sieve excessively, was more preferably 160 mesh sieves);

(5) by step (1)-(4) gained fine powder mix homogeneously, sterile packaged is carried out by pharmaceutically accepted specification.

5., according to the arbitrary described breast tumor blood circulation promoting and blood stasis dispelling preparation of claim 1-3, it is characterized in that, the preparation method of described decoction, step is as follows:

(1) cleaned by Nodus Nelumbinis Rhizomatis, be placed in stone mortar and smash to pieces, wear into Rhizoma Nelumbinis slurry, pulp washing, rinsing, precipitation, drains, and take out, dry in the sun 2-3 hour, chips powder ball with cutter; Continue to dry, smash;

(2) Os Sepiae is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) Poria, Fructus Trichosanthis and Chinese fanpalm seed are placed in frying pan, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), and spray rice vinegar, flood intense fire fried dry after 3-5 minute, taking-up is dried in the air cool;

(4) Radix Scrophulariae, Rhizoma Sparganii, Rhizoma Curcumae, Radix Asparagi, Caulis Bambusae In Taenia, Radix Stellariae Yunnanensis and Radix Phytolaccae are placed in marmite, soak half an hour, intense fire is boiled, turn slow fire boiling 30-50 minute (preferably turn slow fire boiling 35-45 minute, be more preferably and turn slow fire boiling 40 minutes), add step (3) gains, Thallus Laminariae (Thallus Eckloniae), Rhizoma Zingiberis Preparatum, Herba stellariae mediae and Herba Eleusines Indicae, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;

(5) step (1)-(2) gains are joined in step (4) gained filtrate, mixing, filter, be concentrated into 1/2 of original volume, sterile packaged, obtain decoction.

6., according to the arbitrary described breast tumor blood circulation promoting and blood stasis dispelling preparation of claim 1-3, it is characterized in that, the preparation method of described capsule, step is as follows:

(1) cleaned by Nodus Nelumbinis Rhizomatis, be placed in stone mortar and smash to pieces, wear into Rhizoma Nelumbinis slurry, pulp washing, rinsing, precipitation, drains, and take out, dry in the sun 2-3 hour, chips powder ball with cutter; Continue to dry, smash;

(2) Os Sepiae is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) Poria, Fructus Trichosanthis and Chinese fanpalm seed are placed in frying pan, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), and spray rice vinegar, flood intense fire fried dry after 3-5 minute, taking-up is dried in the air cool;

(4) Radix Scrophulariae, Rhizoma Sparganii, Rhizoma Curcumae, Radix Asparagi, Caulis Bambusae In Taenia, Radix Stellariae Yunnanensis and Radix Phytolaccae are placed in marmite, soak half an hour, intense fire is boiled, turn slow fire boiling 30-50 minute (preferably turn slow fire boiling 35-45 minute, be more preferably and turn slow fire boiling 40 minutes), add step (3) gains, Thallus Laminariae (Thallus Eckloniae), Rhizoma Zingiberis Preparatum, Herba stellariae mediae and Herba Eleusines Indicae, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;

(5) join in step (4) gained filtrate by step (1)-(2) gains, mixing, is condensed into the thick paste that relative density is 1.10-1.20, be modulated into the soft material that light pressure is then loose, cross 80-120 mesh sieve (preferred 90-110 mesh sieve, is more preferably 100 mesh sieves), dry, pulverize, obtain medicated powder;

(6) step (5) gained medicated powder is made capsule (preferably by the specification of 0.5g/ grain) by the specification of 0.4g-0.6g/ grain.

7. breast tumor blood circulation promoting and blood stasis dispelling preparation capsule preparation method thereof according to claim 6, is characterized in that: step (5) is preferably condensed into the thick paste that relative density is 1.13-1.17, is more preferably and is condensed into the thick paste that relative density is 1.15.

8., according to the arbitrary described breast tumor blood circulation promoting and blood stasis dispelling preparation of claim 1-3, it is characterized in that, the preparation method of described pill, step is as follows:

(1) cleaned by Nodus Nelumbinis Rhizomatis, be placed in stone mortar and smash to pieces, wear into Rhizoma Nelumbinis slurry, pulp washing, rinsing, precipitation, drains, and take out, dry in the sun 2-3 hour, chips powder ball with cutter; Continue to dry, smash;

(2) Os Sepiae is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) Poria, Fructus Trichosanthis and Chinese fanpalm seed are placed in frying pan, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), and spray rice vinegar, flood intense fire fried dry after 3-5 minute, taking-up is dried in the air cool;

(4) Radix Scrophulariae, Rhizoma Sparganii, Rhizoma Curcumae, Radix Asparagi, Caulis Bambusae In Taenia, Radix Stellariae Yunnanensis and Radix Phytolaccae are placed in marmite, soak half an hour, intense fire is boiled, turn slow fire boiling 30-50 minute (preferably turn slow fire boiling 35-45 minute, be more preferably and turn slow fire boiling 40 minutes), add step (3) gains, Thallus Laminariae (Thallus Eckloniae), Rhizoma Zingiberis Preparatum, Herba stellariae mediae and Herba Eleusines Indicae, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;

(5) step (1)-(2) gains are joined in step (4) gained filtrate, mixing, be condensed into the thick paste that relative density is 1.10-1.30 and (be preferably condensed into the thick paste that relative density is 1.15-1.25, be more preferably and be condensed into the thick paste that relative density is 1.20), be modulated into the soft material that light pressure is then loose, cross 80-120 mesh sieve (preferred 90-110 mesh sieve, be more preferably 100 mesh sieves), dry, pulverize, obtain medicated powder;

(6) Mel is placed in pot, slow fire is tempered to thick, mixes step (5) gained medicated powder, fully mixes into ointment thoroughly, pill (preferably make the pill that diameter is 3mm-5mm, be more preferably and make the pill that diameter is 4mm) is made by traditional Chinese medical science tradition pill method.

9. the preparation method of breast tumor blood circulation promoting and blood stasis dispelling preparation pill according to claim 8, is characterized in that: the consumption of the preferred Mel of step (6) is the 30%-40% of medicated powder quality, and the consumption being more preferably Mel is 35% of medicated powder quality.

10., according to the arbitrary described breast tumor blood circulation promoting and blood stasis dispelling preparation of claim 1-3, it is characterized in that, the preparation method of described tablet, step is as follows:

(1) cleaned by Nodus Nelumbinis Rhizomatis, be placed in stone mortar and smash to pieces, wear into Rhizoma Nelumbinis slurry, pulp washing, rinsing, precipitation, drains, and take out, dry in the sun 2-3 hour, chips powder ball with cutter; Continue to dry, smash;

(2) Os Sepiae is smashed, be placed in mortar, add clear water and grind to form pasty state, add water stirring, inclines and get suspension, the coarse powder of sinking as above method repeatable operation 2-3 time, discard impurity, merge suspension, leave standstill 2-4 hour, the clear water inclined above, get precipitation to dry, porphyrize, excessively 120-160 mesh sieve (preferred 130-150 mesh sieve excessively, was more preferably 140 mesh sieves);

(3) Poria, Fructus Trichosanthis and Chinese fanpalm seed are placed in frying pan, moderate heat is fried 20-30 minute (preferred moderate heat fries 23-27 minute, is more preferably moderate heat and fries 25 minutes), and spray rice vinegar, flood intense fire fried dry after 3-5 minute, taking-up is dried in the air cool;

(4) Radix Scrophulariae, Rhizoma Sparganii, Rhizoma Curcumae, Radix Asparagi, Caulis Bambusae In Taenia, Radix Stellariae Yunnanensis and Radix Phytolaccae are placed in marmite, soak half an hour, intense fire is boiled, turn slow fire boiling 30-50 minute (preferably turn slow fire boiling 35-45 minute, be more preferably and turn slow fire boiling 40 minutes), add step (3) gains, Thallus Laminariae (Thallus Eckloniae), Rhizoma Zingiberis Preparatum, Herba stellariae mediae and Herba Eleusines Indicae, decoct twice, boil 30-40 minute (preferably boil 33-37 minute at every turn, be more preferably and boil 35 minutes at every turn), twice filtrate merges at every turn;

(5) step (1)-(2) gains are joined in step (4) gained filtrate, mixing, be condensed into the thick paste that relative density is 1.10-1.30 and (be preferably condensed into the thick paste that relative density is 1.15-1.25, be more preferably and be condensed into the thick paste that relative density is 1.20), with fashion of extrusion by 18-26 eye mesh screen (preferred 20-24 eye mesh screen excessively, was more preferably 22 eye mesh screens), make single-size, drying, is pressed into lamellar, sugar coating.