CN106377646A - Six-ingredient rehmannia root granule and preparation method thereof - Google Patents
Six-ingredient rehmannia root granule and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/88—Liliopsida (monocotyledons)
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- A61K2236/50—Methods involving additional extraction steps
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Abstract
The invention belongs to the field of Chinese patent medicine recipe application to fresh traditional Chinese medicine technical extraction, and particularly relates to a six-ingredient rehmannia root granule and a preparation method thereof. The six-ingredient rehmannia root granule is prepared through the following steps that 100 to 500 weight parts of fresh prepared rehmannia roots,50 to 350 weight parts of fresh prepared dogwood, 40 to 300 weight parts of fresh cortex moutan, 60 to 400 weight parts of fresh yam, 10 to 350 weight parts of fresh poria cocos and 40 to 300 weight parts of fresh rhizoma alismatis are proportioned and used as fresh active pharmaceutical ingredients; water is added into the active pharmaceutical ingredients for soaking for 1 to 4 hours; then, low-temperature extraction and filtering are performed to obtain extraction liquid and medicine slag; the extraction liquid is concentrated into liquid extracts with the specific gravity being 1.20 to 1.35; medicine slag is dried and crushed into fine powder; the liquid extracts with the specific gravity being 1.20 to 1.35 and the medicine slag fine powder or partial medicine slag fine powder are uniformly stirred and mixed; freeze drying is performed; the six-ingredient rehmannia root granule can be obtained. The six-ingredient rehmannia root granule provided by the invention has the advantages that no harmful substances and no pesticide re remained; the biological activity is high; the medicine effect is good.
Description
Technical field
The invention belongs to technical field of Chinese medicines, specifically, it is related to a kind of Liuwei Dihuang granule agent and preparation method thereof.
Background technology
Six drugs containing rehmanniae is made up of Radix Rehmanniae Preparata, Fructus Corni, Rhizoma Dioscoreae, Rhizoma Alismatis, Cortex Moutan, Poria Six-element Chinese medicine.In Six-element medical material
Containing the various active composition such as polysaccharide, glycoside, terpenoid, research shows：In six drugs containing rehmanniae, acidic polysaccharose CA4-3 can be done directly on
B cell, improves immunity of organisms.In Fructus Corni, polysaccharide PFCAIII effectively can suppress vegetable oil being oxygenized, has removing free radical to make
With.In Fructus Corni, terpenoid ursolic acid has blood fat reducing, effect of lowering blood sugar.After paeonol in Cortex Moutan is widely used to fracture operation
The aspects such as easing pain and diminishing inflammation, promotion knitting and anxiolytic drugs preparation, toxic and side effects are little compared with Conventional analgesics class medicine, treatment
Mitigation is lasting afterwards.Six drugs containing rehmanniae is used for the symptoms such as enriching yin and nourishing kidney, dizziness and tinnitus, soreness of the waist and knees, night sweat seminal emission, has anti-
Cancer, improve human immunity, anti-aging effects, be clinically widely used in treating tens of kinds of diseases, such as hypertension, diabetes,
Chronic nephritiss, climacteric syndrome, old-slow-bronchial tube and chemotherapy of tumors etc..
LIUWEI DIHUANG WAN (concentrated pill) its prescription that the Sanitation Ministry medicine standard WS3-B-2102-96 records is by Radix Rehmanniae Preparata
160g, Fructus Corni (processed) 80g, Cortex Moutan 60g, Rhizoma Dioscoreae 80g, Poria 60g and Rhizoma Alismatis 60g Six-element medicine composition altogether.Its preparation method is
Cortex Moutan is extracted paeonol；Medicinal residues and Fructus Corni 27g, Radix Rehmanniae Preparata, Poria, Rhizoma Alismatis add water to cook secondary, 2 hours every time, close
And decocting liquid, filtration；Above thick paste, fine powder, paeonol are mixed, pill, be dried, polishing, obtain final product.LIUWEI DIHUANG WAN is clinically
Zeng Lidai has played the efficiency of brilliance, but the progress with medical sci-tech, finds that its effect is slow, sugary is unfavorable for diabeticss
Take, moisture is high, easily go mouldy, be unfavorable for the shortcomings of store.
Liuwei Dihuang granule agent instead of conventional dosage forms, both can guarantee that the content of active compound composition, simultaneously little but also with consumption,
In good taste, rapid-action, the high advantage of curative effect.
CN1279965A discloses a kind of granule of six drugs containing rehmanniae, and this granule is with Radix Rehmanniae Preparata, Fructus Corni, Paeonia suffruticosa
Skin, Rhizoma Dioscoreae, Poria, Rhizoma Alismatis are raw material, through post bake water extraction, filter, concentrating under reduced pressure becomes fluid extract, medicinal residues are ground into carefully
Powder, medicinal residues fine powder is mixed with fluid extract, is spray dried to granule medicated powder.This bead dosage form is easily dissolved with moisture infiltration, can quilt
Rapid absorption, curative effect is rapidly it is easy to preserve.Its preparation method feeds intake accurately, and thermal sensitivity or effumability composition are difficult to lose.
" suspension type Liuwei Dihuang granule agent preparation technology and pharmacodynamic study "【Liu Sheng, Shi Jianqin, etc. suspension type Six-element
Radix Rehmanniae Preparation Technology of Granules and pharmacodynamic study (J). Liaoning Journal of Traditional Chinese Medicine, 2007,24 (9)：1299-1300】Disclose one
Plant the preparation technology of suspension type Liuwei Dihuang granule agent, and compare Liuwei Dihuang granule agent and six drugs containing rehmanniae pill pharmacological action
Difference.The preparation method of this Liuwei Dihuang granule agent is that the Rhizomadioscoreae Fructus Evodiae, Cortex Moutan are removed debris drying 1h, is respectively crushed into
120 mesh fine powders are standby.Radix Rehmanniae Preparata, Rhizoma Alismatis, Rhizoma Dioscoreae, Poria water extraction 2 times, are condensed into 1.3 fluid extract, precipitate with ethanol 24h, make granule
Agent.
However, not only there is harmful substance pesticide residues, heavy metals exceeding standard or processing in the granular medicine that said method is obtained
The problems such as pollution residual, and its biological activity is not high so that its curative effect is not high.
In view of this special proposition present invention.
Content of the invention
The technical problem to be solved in the present invention is to overcome the deficiencies in the prior art, provide a kind of Liuwei Dihuang granule agent and
Its preparation method, this Liuwei Dihuang granule agent overcome dry raw material of Chinese medicine exist harmful substance pesticide residues, heavy metals exceeding standard or
The problems such as process pollution residual；Biological activity is high simultaneously, thus improve curative effect.
For solving above-mentioned technical problem, the present invention adopts the following technical scheme that：
A kind of Liuwei Dihuang granule agent, wherein：Described Liuwei Dihuang granule agent is by fresh Radix Rehmanniae Preparata 100～500 weight
Part, fresh Fructus Corni (processed) 50～350 weight portion, fresh Cortex Moutan 40～300 weight portion, fresh Rhizoma dioscoreae 60～400 weight portion, fresh Poria 10
～350 weight portions and fresh 40～300 weight portion dispensings of rushing down are fresh raw medicinal material, soak 1～4 hour in raw medicinal material
Carry out extract at low temperature, filter, obtain extracting solution and medicinal residues；Extracting solution is condensed into the fluid extract of proportion 1.20～1.35, by medicine
Slag is dried, and is ground into fine powder, and the fluid extract of proportion 1.20～1.35 is mixed all with medicinal residues fine powder or the stirring of part medicinal residues fine powder
Even, carry out lyophilization, obtain final product described Liuwei Dihuang granule agent.
Liuwei Dihuang granule agent of the present invention, wherein：Described extract at low temperature is at 60 DEG C of 35 DEG C≤temperature ＜
Extracted.
Further, described extract at low temperature is at least to be extracted twice at 60 DEG C of 35 DEG C≤temperature ＜；Preferably
Once it is extracted in and carries out at 45 DEG C of 35 DEG C≤temperature ＜, be extracted in for the second time and carry out at 60 DEG C of 45 DEG C≤temperature ＜.
Further, described lyophilization is to carry out at -55 DEG C～-2 DEG C of temperature.
The present invention also provides the preparation method of described Liuwei Dihuang granule agent, and the method comprises the steps：
1) fresh Radix Rehmanniae Preparata 100～500 weight portion, fresh Fructus Corni (processed) system 50～350 weight portion, fresh Cortex Moutan 40～300 are pressed
Weight portion, fresh Rhizoma dioscoreae 60～400 weight portion, fresh Poria 40～350 weight portion and fresh rush down 40～300 weight portion dispensings, through pre-
Process as fresh raw medicinal material；
2) add water in the fresh raw medicinal material after dispensing and carry out extract at low temperature, filter, obtain extracting solution and medicinal residues；
3) extracting solution is condensed into fluid extract, medicinal residues ovendry power is broken into fine powder, by fluid extract and medicinal residues fine powder or part
Medicinal residues fine powder is uniformly mixed, and carries out lyophilization, obtains final product described Liuwei Dihuang granule agent.
In above-mentioned preparation method, wherein：Step 2) described in extract at low temperature be to carry out at 60 DEG C of 35 DEG C≤temperature ＜
Extract.
Preferably, described extract at low temperature is at least to be extracted twice at 60 DEG C of 35 DEG C≤temperature ＜.
It is further preferred that be extracted in for the first time carrying out at 45 DEG C of 35 DEG C≤temperature ＜, it is extracted in 45 DEG C≤temperature ＜ 60 for the second time
Carry out at DEG C.
Further, step 3) in, described cryodesiccated temperature is -55 DEG C～-2 DEG C.
Further, described concentration be carry out reducing pressure at pressure 0.06～0.09MPa, 30～65 DEG C of temperature dense
Contracting.
Hereinafter the present invention is described in detail：
CN1279965A discloses a kind of granule of six drugs containing rehmanniae, but this granule doing using storage a period of time
Raw material of Chinese medicine is prepared from, on the one hand due to dry raw material of Chinese medicine be long placed in easily mould lose rotten, on the other hand dry raw material of Chinese medicine there are
Evil material pesticide residues, heavy metals exceeding standard or process pollution residual the problems such as, and its biological activity not high so that its curative effect not
High.In view of this, the present invention provides a kind of Liuwei Dihuang granule agent using the preparation of fresh raw material of Chinese medicine medical material, solves existing skill
The problems referred to above present in art.
Specifically, the present invention provides a kind of granule of six drugs containing rehmanniae, and described Liuwei Dihuang granule agent is by fresh ripe
Radix Rehmanniae 100～500 weight portion, fresh Fructus Corni (processed) 50～350 weight portion, fresh Cortex Moutan 40～300 weight portion, fresh Rhizoma dioscoreae 60～
400 weight portions, fresh Poria 10～350 weight portion and fresh 40～300 weight portion dispensings of rushing down are fresh raw medicinal material, to raw medicinal material
In soak 1～4 hour and carry out extract at low temperature, filter, obtain extracting solution and medicinal residues；By extracting solution be condensed into proportion 1.20～
1.35 fluid extract, medicinal residues are dried, and are ground into fine powder, by the fluid extract of proportion 1.20～1.35 and medicinal residues fine powder or part medicine
Slag fine powder is uniformly mixed, and carries out lyophilization, obtains final product described Liuwei Dihuang granule agent.
The present invention adopt fresh raw material of Chinese medicine medical material, on the one hand avoid raw material of Chinese medicine be long placed in easily mould lose spoilage problems, another
Aspect overcomes dry raw material of Chinese medicine to be haveed such problems as harmful substance pesticide residues, heavy metals exceeding standard or processes pollution residual；Meanwhile,
The present invention adopts extract at low temperature and lyophilization, improves biological activity, thus improve curative effect.
The present invention also provides the preparation method of described Liuwei Dihuang granule agent, and the method comprises the steps：
1) fresh Radix Rehmanniae Preparata 100～500 weight portion, fresh Fructus Corni (processed) system 50～350 weight portion, fresh Cortex Moutan 40～300 are pressed
Weight portion, fresh Rhizoma dioscoreae 60～400 weight portion, fresh Poria 40～350 weight portion and fresh rush down 40～300 weight portion dispensings, through pre-
Process as fresh raw medicinal material；
2) add water in the fresh raw medicinal material after dispensing and carry out extract at low temperature, filter, obtain extracting solution and medicinal residues；
3) extracting solution is condensed into fluid extract, medicinal residues ovendry power is broken into fine powder, by fluid extract and medicinal residues fine powder or part
Medicinal residues fine powder is uniformly mixed, and carries out lyophilization, obtains final product described Liuwei Dihuang granule agent.
In above-mentioned preparation method, wherein：Step 2) described in extract at low temperature be to carry out at 60 DEG C of 35 DEG C≤temperature ＜
Extract.
The present invention adopts extract at low temperature, substantially increases its biological activity.
For fully ensuring that its biological activity, described extract at low temperature is at least to carry out twice at 60 DEG C of 35 DEG C≤temperature ＜
Extract.The present invention, can be extracted twice as needed, extracted for three times, be extracted for four times ...
It is further preferred that be extracted in for the first time carrying out at 45 DEG C of 35 DEG C≤temperature ＜, it is extracted in 45 DEG C≤temperature ＜ 60 for the second time
Carry out at DEG C.
The present invention is extracted using under the temperature range different at two, and effective ingredient can be made to be fully extracted, greatly
Big raising extraction ratio.
Further, step 3) in, described cryodesiccated temperature is -55 DEG C～-2 DEG C.
Further, described concentration be carry out reducing pressure at pressure 0.06～0.09MPa, 30～65 DEG C of temperature dense
Contracting.
In order to ensure that fresh Chinese medicine extraction Chinese patent medicine LIUWEI DIHUANG WAN has better quality, each fresh goods raw medicinal material is carried out
Pretreatment.Described pretreatment is exactly to select up-to-standard fresh Radix Rehmanniae Preparata, fresh Fructus Corni (system), fresh Cortex Moutan, fresh Rhizoma dioscoreae, fresh
Poria, the fresh content rushed down, analyze the effective ingredient as raw medicinal material with the assay method of national mark product, see whether it accords with
Close required standard, rinse qualified raw medicinal material with water, until the color of water is limpid, then raw medicinal material is dried or drenches
Dry.
In order to improve the extraction ratio of effective ingredient in fresh goods raw medicinal material, raw medicinal material can be cut into slices, block or be ground into
Graininess, this is that those of ordinary skill belonging to this area all knows.Appropriate water is added to soak 1～4 in raw medicinal material little
When, water used can be one of tap water, distilled water or deionized water.
Described weight portion can be gram, money, jin, the unit of weight such as kilogram, ton.
After technique scheme, the present invention compared with prior art has the advantages that：
1st, fresh medicine is extracted LIUWEI DIHUANG WAN novel form and the LIUWEI DIHUANG WAN of decoction pieces dry medicine extraction, right in clinical drug effect
Improve 3～5 times than relatively.
2nd, the LIUWEI DIHUANG WAN novel form that fresh medicine is extracted guarantees that pesticide residues and heavy metal control indexes point are zero, and reduces
Pesticide residues and the serious harm of heavy metals exceeding standard.
3rd, the epigranular of the LIUWEI DIHUANG WAN novel form of the present invention, color and luster is consistent, and granule combines crisp it is easy to moisture
Infiltration, dissolving, form suspension with water, can be rapidly absorbed, curative effect is notable rapidly after entering human body.The product of the present invention is no
Sugar-type is it is adaptable to the diabeticss of unsuitable dietary sugars.
4th, contain medicinal residues fine powder in new dose of LIUWEI DIHUANG WAN of the present invention, increased Plant fiber in medicine, take containing
The medicine of a large amount of Plant fiber, is beneficial to the health of human body, enhances the curative effect of medicine, increased the picked-up of plant crude fiber
Amount, clears up internal free radical.
5th, LIUWEI DIHUANG WAN novel form of the present invention is easy to carry, takes, be easy to again transport preserve, steady quality, low temperature,
High warm purgative thing invariance, does not go mouldy.
Specific embodiment
Purpose, technical scheme and advantage for making the embodiment of the present invention are clearer, below in conjunction with the embodiment of the present invention,
Technical scheme in embodiment is clearly and completely described, following examples are used for the present invention is described, but are not limited to
The scope of the present invention.
Embodiment 1
The present embodiment adopts the novel form of the Chinese patent medicine LIUWEI DIHUANG WAN of fresh Chinese medicine extraction, by 160 grams of fresh Radix Rehmanniae Preparata, fresh mountain
80 grams of the Fructus Evodiae (system), 60 grams of fresh Cortex Moutan, 80 grams of fresh Rhizoma dioscoreae, 60 grams of fresh Poria, fresh rush down 60 grams, dispensing is raw medicinal material.To
Add water in raw medicinal material and carry out heating extraction, filter, extracting solution is condensed into the fluid extract of proportion 1.28, by medicinal residues dries pulverizing
Become medicinal residues fine powder, the medicinal residues fine powder of the fluid extract of proportion 1.28 and the 20% of medicinal residues gross weight is uniformly mixed, is frozen
Drying forms the LIUWEI DIHUANG WAN medicated powder that average medicated powder particle diameter is 900 μm.
1) press 160 grams of fresh Radix Rehmanniae Preparata, 80 grams of fresh Fructus Corni (system), 60 grams of fresh Cortex Moutan, 80 grams of fresh Rhizoma dioscoreae, fresh Poria 60
Gram, fresh rush down 60 grams of dispensings, standard compliant above-mentioned medical material tap water is constantly rinsed raw medicinal material, until water color clear
Till clear, drench dry.The water (not having medical material) adding Sq soaks 1～4 hour, as extract at low temperature raw material.
2) add the water of 7 times amount of raw medicinal material gross weight in above-mentioned raw medicinal material, in 45 DEG C of 35 DEG C≤temperature ＜
At a temperature of, heating extraction 4 hours, take out first time extracting solution, obtain first time extracting solution and first time medicinal residues.
3) add the water of 5 times amount of raw medicinal material gross weight in first time medicinal residues, in 60 DEG C of temperature of 45 DEG C≤temperature ＜
The lower heating extraction of degree 2 hours, takes out second extracting solution, obtains second extracting solution and second medicinal residues.
4) merge first and second extracting solution, filter, to the extracting solution through filtering, in the temperature of pressure 0.07Mpa, 65 DEG C
Carry out concentrating under reduced pressure under conditions of degree, be concentrated into the fluid extract that proportion is 1.28.
5), after second medicinal residues being dried at a temperature of 70 DEG C, it is ground into medicinal residues fine powder, makes medicinal residues fine powder cross 400 mesh,
The fluid extract that the 20% of medicinal residues gross weight medicinal residues fine powder and above-mentioned proportion are 1.28 is uniformly mixed formation mixture.
6) with lyophilization, lyophilization is carried out to the mixture of medicinal residues fine powder and fluid extract.Pressure is 0.5MPa, lyophilizing
The temperature being dried is -2～-55 DEG C.Specifically the mixing of medicinal residues fine powder and fluid extract is generated average medicated powder particle diameter 900
μm LIUWEI DIHUANG WAN powdered granule, carry out subpackage, instruct occupation mode.
Embodiment 2
Its formula is substantially the same manner as Example 1 with preparation method, only unlike, by first and second time merging and pass through
The extracting solution filtering is condensed into the fluid extract of proportion 1.25, by the medicinal residues of the fluid extract of proportion 1.25 and the 25% of medicinal residues gross weight
Fine powder is uniformly mixed.
Embodiment 3
Its formula is substantially the same manner as Example 1 with preparation method, only unlike, by first and second time merging and pass through
The extracting solution filtering is condensed into the fluid extract of proportion 1.30, by the medicinal residues of the fluid extract of proportion 1.30 and the 15% of medicinal residues gross weight
Fine powder is uniformly mixed.
Embodiment 4
Its formula is substantially the same manner as Example 1 with preparation method, only unlike：
100 grams of Radix Rehmanniae Preparata, 50 grams of Fructus Corni (system), 40 grams of Cortex Moutan, 60 grams of Rhizoma Dioscoreae, 40 grams of Poria, 40 grams of Rhizoma Alismatis.To close
And extracting solution be condensed into the fluid extract of proportion 1.20.Medicinal residues dries pulverizing is become medicinal residues fine powder, by the fluid extract of proportion 1.20
Be uniformly mixed with the 50% of medicinal residues gross weight medicinal residues fine powder, carry out spray drying and form average medicated powder particle diameter be
2000 μm of LIUWEI DIHUANG WAN medicated powder.
Its preparation method：
1) 100 grams of Radix Rehmanniae Preparata, 50 grams of Fructus Corni (system), 40 grams of Cortex Moutan, 60 grams of Rhizoma Dioscoreae, 40 grams of Poria, 40 grams of Rhizoma Alismatis are pressed
Dispensing.
2) add the water of 6 times amount of raw medicinal material gross weight in above-mentioned raw medicinal material, heat at a temperature of 40 DEG C and carry
Take 6 hours.
3) water of 4 times amount of raw medicinal material gross weight, at a temperature of 50 DEG C, heating extraction are added in first time medicinal residues
0.5 hour.
4) at a temperature of pressure 0.09Mpa, 45 DEG C, vacuum distillation is concentrated into the fluid extract that proportion is 1.20.
5) second medicinal residues be dry, pulverize into medicinal residues fine powder at a temperature of 55 DEG C, make medicinal residues fine powder cross 800 mesh, will
The medicinal residues fine powder of the 50% of medicinal residues gross weight is uniformly mixed with the fluid extract that above-mentioned proportion is 1.20.
6) with nitrogen as atomization gas, the pressure of atomization gas is 0.2MPa, and the temperature of lyophilization is -2～-55 DEG C,
Generate the LIUWEI DIHUANG WAN powdered granule that average medicated powder particle diameter is 2000 μm.
Embodiment 5
Its formula is substantially the same manner as Example 1 with preparation method, only unlike：
500 grams of fresh Radix Rehmanniae Preparata, 350 grams of fresh Fructus Corni (system), 300 grams of fresh Cortex Moutan, 400 grams of fresh Rhizoma dioscoreae, fresh Poria 35)
Gram, fresh rush down 300 grams.The extracting solution of merging is condensed into the fluid extract of proportion 1.35.Medicinal residues dries pulverizing is become medicinal residues fine powder,
The medicinal residues fine powder of the fluid extract of proportion 1.35 and the 10% of medicinal residues gross weight is uniformly mixed, carry out lyophilization form flat
All medicated powder particle diameter is 1000 μm of LIUWEI DIHUANG WAN medicated powder.
Its preparation method：
1) press 500 grams of fresh Radix Rehmanniae Preparata, 350 grams of fresh Fructus Corni (system), 300 grams of fresh Cortex Moutan, 400 grams of fresh Rhizoma dioscoreae, fresh Poria
350 grams, fresh rush down 300 grams of dispensings.
2) add the water of 8 times amount of raw medicinal material gross weight in above-mentioned fresh goods raw medicinal material, in 35 DEG C≤temperature ＜ 45
Heating extraction 1 hour at a temperature of DEG C.
3) add the water of 7 times amount of raw medicinal material gross weight in first time medicinal residues, in 60 DEG C of temperature of 45 DEG C≤temperature ＜
Under degree, heating extraction 3 hours.
4) at a temperature of pressure 0.06Mpa, 70 DEG C, vacuum distillation is concentrated into the fluid extract that proportion is 1.35.
5) second medicinal residues be dry, pulverize into medicinal residues fine powder at a temperature of 70 DEG C, make medicinal residues fine powder cross 200 mesh, will
The medicinal residues fine powder of the 10% of medicinal residues gross weight is uniformly mixed with the fluid extract that above-mentioned proportion is 1.35.
6) with pressure as 0.9MPa, the temperature of lyophilization is -2～-55 DEG C, and generating average medicated powder particle diameter is 1000
μm LIUWEI DIHUANG WAN powdered granule.
Comparative example 1, prepare Liuwei Dihuang granule according to the method for CN1279965A embodiment 1
The novel form of the Chinese patent medicine LIUWEI DIHUANG WAN of this comparative example, by 160 grams of Radix Rehmanniae Preparata, 80 grams of Fructus Corni (system), Paeonia suffruticosa
60 grams of skin, 80 grams of Rhizoma Dioscoreae, 60 grams of Poria, 60 grams of Rhizoma Alismatis, dispensing is raw medicinal material.Add water in raw medicinal material and carry out heating and carry
Take, filter, extracting solution is condensed into the fluid extract of proportion 1.28, medicinal residues dries pulverizing is become medicinal residues fine powder, by proportion 1.28
Fluid extract and the 20% of medicinal residues gross weight medicinal residues fine powder are uniformly mixed, and carrying out spray drying, to form average medicated powder granule straight
Footpath is 900 μm of LIUWEI DIHUANG WAN medicated powder.
The preparation method of its LIUWEI DIHUANG WAN novel form is：
1) 160 grams of Radix Rehmanniae Preparata, 80 grams of Fructus Corni (preparation), 60 grams of Cortex Moutan, 80 grams of Rhizoma Dioscoreae, 60 grams of Poria, Rhizoma Alismatis 60 are pressed
Gram dispensing, standard compliant above-mentioned medical material tap water is constantly rinsed raw medicinal material, till the color of water is limpid, drenches
Dry.The water (not having medical material) adding Sq soaks 40 minutes, takes out as raw material.
2) add the water of 7 times amount of raw medicinal material gross weight in above-mentioned raw medicinal material, heat at a temperature of 90 DEG C and carry
Take 4 hours, take out first time extracting solution, obtain first time extracting solution and first time medicinal residues.
3) water of 5 times amount of raw medicinal material gross weight, heating extraction 2 at a temperature of 90 DEG C are added in first time medicinal residues
Hour, take out second extracting solution, obtain second extracting solution and second medicinal residues.
4) merge first and second extracting solution, filter, to the extracting solution through filtering, in pressure 0.07Mpa, 65 DEG C of temperature
Carry out concentrating under reduced pressure under conditions of degree, be concentrated into the fluid extract that proportion is 1.28.
5), after second medicinal residues being dried at a temperature of 85 DEG C, it is ground into medicinal residues fine powder, makes medicinal residues fine powder cross 400 mesh,
The fluid extract that the 20% of medicinal residues gross weight medicinal residues fine powder and above-mentioned proportion are 1.28 is uniformly mixed formation mixture.
6) with water vapor gas as atomization gas, the mixture of medicinal residues fine powder and fluid extract is spray-dried.Atomization
The pressure of gas is 0.5Mpa, and the temperature being dried is 300 DEG C.Specifically the mixture of medicinal residues fine powder and fluid extract is passed through spray
Mist head sprays in hot-air, and the temperature of hot-air is 300 DEG C, generates the six drugs containing rehmanniae powder that average medicated powder particle diameter is 900 μm
Shape granule, carries out subpackage, instructs occupation mode.
Comparative example 2
Preparation method：
Fructus Corni 80g, Cortex Moutan 60g two taste medicine mixed powder are broken into 120 mesh fine powders.Rhizoma Dioscoreae 80g, Rhizoma Alismatis 60g, Radix Rehmanniae Preparata 160g
Boil 2 times with Poria 60g four Chinese medicine decocting, the 1st time plus 8 times amount decocting 1h, add 6 times amount decocting 1h the 2nd time.Filtrate merges twice
After being concentrated to 200ml, plus the ethanol stirring of doubling dose volume fraction 0.95, place 24h, filter.Reclaim ethanol, be concentrated to leaching
Cream, plus Fructus Corni, Cortex Moutan fine powder, cyclamate 1.0g, dextrin 75g mix, and dry, are ground into 100 mesh fine powders.Use volume fraction
Soft material made by 0.60 ethanol, pelletizes, 70 DEG C of drying, granulate, 100 bags of subpackage, every bag of 5g.
The comparision contents of paeonol and loganin in test example 1, six drugs containing rehmanniae
This test example compares the content of paeonol and loganin in the six drugs containing rehmanniae powder particle that different methods are obtained.
The assay result of paeonol and loganin in the six drugs containing rehmanniae powder particle that table 1, distinct methods are obtained
(mg·g-1,)
| Sample | Paeonol | Loganin |
| Embodiment 1 | 4.2±1.9 | 3.7±1.6 |
| Embodiment 2 | 4.3±2.3 | 3.8±1.4 |
| Embodiment 3 | 4.4±1.7 | 3.6±1.5 |
| Embodiment 4 | 4.3±2.4 | 3.8±1.1 |
| Embodiment 5 | 4.4±2.6 | 3.9±1.2 |
| Comparative example 1 | 2.1±1.9 | 1.8±1.3 |
| Comparative example 2 | 2.3±1.6 | 1.9±1.1 |
Can be seen that paeonol and horse the Liuwei Dihuang granule being obtained using the method for the present invention from above-mentioned result of the test
The Liuwei Dihuang granule that the content of money glycosides is obtained apparently higher than the method using prior art.
Test example 2, pharmacodynamics test
Impact to Tolerance of Swimming：Take Kunming mouse 80, be divided into 4 groups, every group 20.(purchased from Beijing experiment
Animal center) weight (20 ± 3) g male and female dual-purpose, it is randomly divided into：Test group 20g kg-1·d-1；Compare 1 group of 20g kg-1·d-1；Compare 2 groups of 20g kg-1·d-1；Physiological saline group 100mL kg-1·d-1.Every group of mice 20, continuously gives for every group
Medicine 7 days (Gastric lavage), administration 2 times daily, before experiment, 1h is administered once.Experiment starts in mouse tail its body constitution of root load
1/10 mass of amount, takes out 2 mices from each group successively and together puts into 28 DEG C of water, observe Tolerance of Swimming, to avale not
When can float to the water surface, it is swimming time.
To mice movable impact naturally：Take kunming mice 80, be divided into 4 groups, every group 20.It is randomly divided into：Test group
20g·kg-1·d-1；Compare 1 group of 20g kg-1·d-1；Compare 2 groups of 20g kg-1·d-1；Physiological saline group 100mL kg-1·
d-1.Every group of mice 20, every group of successive administration 7 days (Gastric lavage), it is administered once before experiment, with GL-1 photoelectric counting generation
Survey the natural number of activities of record mice 5min, every group of mice all in kind surveys the natural work before record administration for first 7 days in administration
Dynamic number of times.
Table 2, the impact to Tolerance of Swimming for the variable grain agent
Table 3, variable grain agent are to mice movable impact naturally
The impact to Tolerance of Swimming for the variable grain agent test result indicate that, test group, 1 group of comparison, 2 groups of comparison little
Mus are compared with saline group, all increased swimming time, enhance endurance, but test group enhancing Endurance is more notable.
Variable grain agent to mice naturally activity impact experimental result through statistical disposition, result shows, test group, comparison
1 group, 2 groups of comparison all have the naturally movable maincenter sedation of suppression mice.Test group with compare 1 group and comparison 2 groups compare, examination
Test group effect notable.
The granule that other embodiments of the present invention are obtained has been also carried out above-mentioned test, and the result that it obtains is similar.
The above is only presently preferred embodiments of the present invention, not the present invention is made with any pro forma restriction, though
So the present invention is disclosed above with preferred embodiment, but is not limited to the present invention, any technology people being familiar with the present invention
Member, in the range of without departing from technical solution of the present invention, makes when the technology contents that above-mentioned prompting can be utilized and a little change or be modified to
The Equivalent embodiments of equivalent variations, as long as being the content without departing from technical solution of the present invention, according to the technical spirit pair of the present invention
Any simple modification, equivalent variations and modification that above example is made, all still fall within the range of the present invention program.
Claims (10)
1. a kind of Liuwei Dihuang granule agent it is characterised in that：Described Liuwei Dihuang granule agent is by fresh Radix Rehmanniae Preparata 100～500
Weight portion, fresh Fructus Corni (processed) 50～350 weight portion, fresh Cortex Moutan 40～300 weight portion, fresh Rhizoma dioscoreae 60～400 weight portion, fresh Fu
Siberian cocklebur 10～350 weight portion and fresh 40～300 weight portion dispensings of rushing down are fresh raw medicinal material, soak 1～4 in raw medicinal material
Hour carries out extract at low temperature, filters, obtains extracting solution and medicinal residues；Extracting solution is condensed into the fluid extract of proportion 1.20～1.35,
Medicinal residues are dried, is ground into fine powder, will be mixed with medicinal residues fine powder or the stirring of part medicinal residues fine powder for the fluid extract of proportion 1.20～1.35
Close uniformly, carry out lyophilization, obtain final product described Liuwei Dihuang granule agent.
2. Liuwei Dihuang granule agent according to claim 1 it is characterised in that：Described extract at low temperature is in 35 DEG C≤temperature
Extracted at 60 DEG C of ＜ of degree.
3. Liuwei Dihuang granule agent according to claim 2 it is characterised in that：Described extract at low temperature is in 35 DEG C≤temperature
At least extracted twice at 60 DEG C of ＜ of degree；Preferably it is extracted in for the first time and carries out at 45 DEG C of 35 DEG C≤temperature ＜, extract for second
Carry out at 60 DEG C of 45 DEG C≤temperature ＜.
4. the Liuwei Dihuang granule agent according to claims 1 to 3 any one it is characterised in that：Described lyophilization
It is to carry out at -55 DEG C～-2 DEG C of temperature.
5. the Liuwei Dihuang granule agent described in a kind of Claims 1 to 4 any one preparation method it is characterised in that：Described
Preparation method comprise the steps：
1) press fresh Radix Rehmanniae Preparata 100～500 weight portion, fresh Fructus Corni (processed) 50～350 weight portion, fresh Cortex Moutan 40～300 weight portion,
Fresh Rhizoma dioscoreae 60～400 weight portion, fresh Poria 40～350 weight portion and fresh rush down 40～300 weight portion dispensings, preprocessed conduct
Fresh raw medicinal material；
2) add water in the fresh raw medicinal material after dispensing and carry out extract at low temperature, filter, obtain extracting solution and medicinal residues；
3) extracting solution is condensed into fluid extract, medicinal residues ovendry power is broken into fine powder, by fluid extract and medicinal residues fine powder or part medicinal residues
Fine powder is uniformly mixed, and carries out lyophilization, obtains final product described Liuwei Dihuang granule agent.
6. preparation method according to claim 5 it is characterised in that：Step 2) described in extract at low temperature be 35 DEG C≤
Extracted at 60 DEG C of temperature ＜.
7. preparation method according to claim 6 it is characterised in that：Described extract at low temperature is in 35 DEG C≤temperature ＜ 60
At least extracted twice at DEG C.
8. preparation method according to claim 7 it is characterised in that：It is extracted in enter at 45 DEG C of 35 DEG C≤temperature ＜ for the first time
OK, it is extracted in for the second time and carry out at 60 DEG C of 45 DEG C≤temperature ＜.
9. the preparation method according to claim 5～8 any one it is characterised in that：Step 3) in, described freezing is done
Dry temperature is -55 DEG C～-2 DEG C.
10. preparation method according to claim 9 it is characterised in that：Described concentration be pressure 0.06～
Carry out concentrating under reduced pressure at 0.09MPa, 30～65 DEG C of temperature.
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| CN108498674A (en) * | 2018-06-28 | 2018-09-07 | 黄建平 | A kind of drug and preparation method thereof for treating hypertension |
| CN108653545A (en) * | 2017-03-29 | 2018-10-16 | 北京龙庆鑫国际医药科技开发有限公司 | A kind of Chinese medicine composition and preparation method treated and/or prevent cardiovascular and cerebrovascular disease |
| CN108653566A (en) * | 2017-03-29 | 2018-10-16 | 北京龙庆鑫国际医药科技开发有限公司 | A kind of Chinese medicine composition and preparation method thereof with white-skinned face function |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108653596A (en) * | 2017-03-28 | 2018-10-16 | 北京龙庆鑫国际医药科技开发有限公司 | A kind of Chinese medicine composition and preparation method thereof with function of reducing blood sugar |
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| CN108653566A (en) * | 2017-03-29 | 2018-10-16 | 北京龙庆鑫国际医药科技开发有限公司 | A kind of Chinese medicine composition and preparation method thereof with white-skinned face function |
| CN108653566B (en) * | 2017-03-29 | 2021-07-23 | 北京龙庆鑫国际医药科技开发有限公司 | Traditional Chinese medicine composition with whitening effect and preparation method thereof |
| CN108498674A (en) * | 2018-06-28 | 2018-09-07 | 黄建平 | A kind of drug and preparation method thereof for treating hypertension |
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