CN101352236B - Big fruit sea-buckthorn compound fatigue-resistant powder and preparation method thereof - Google Patents
Big fruit sea-buckthorn compound fatigue-resistant powder and preparation method thereof Download PDFInfo
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Abstract
A big-fruit seabuckthern compound anti-fatigue powder and a preparation method thereof relate to an anti-fatigue product and a preparation method thereof. The invention solves the problems that a plurality of plant extracts are contained in the anti-fatigue product, the anti-fatigue effect is not good, and the production process is complicated. The big-fruit seabuckthern anti-fatigue powder is made from 85%-95% of big-fruit seabuckthorn fruit pulp and 5%-15% of a rhodiola root extract. The preparation method of the big-fruit seabuckthorn compound anti-fatigue powder comprises the following steps: big-fruit seabuckthorn fruit pulp is made by breaking, filtering, grinding and precipitating fresh big-fruit seabuckthorn fruits; the big-fruit seabuckthorn compound anti-fatigue powder is made by mixing, homogenizing, drying and crushing the big-fruit seabuckthorn fruit pulp and the rhodiola root extract. The big-fruit seabuckthorn compound anti-fatigue powder is a natural compound anti-fatigue health product; animal tests prove that the big-fruit seabuckthorn compound anti-fatigue powder can increase the exercise tolerance of mice by more than twice, has good anti-fatigue effect, can effectively relieve fatigue, and can be applicable to all groups of people.
Description
Technical field
The present invention relates to a kind of anti-fatigue product and preparation method thereof.
Background technology
Current social life rhythm is accelerated day by day, and people's life stress constantly increases, and work makes people be in sub-health state for a long time in high-pressure, busy muscle power and the brain, and sense of fatigue also strengthens day by day.
Existing in the market anti-fatigue medicament contains the excitant composition more, and scientific research proves, doping meeting grievous injury people's physical and mental health.Active component in the natural plants more and more receives publicity because its side effect is little, safe, it is wide to adapt to.Sea-buckthorn and rhodiola root are classified as medicine food dual purpose plant by the Ministry of Public Health, and they all have good effect at aspects such as improving body immunity, prevention cardiovascular and cerebrovascular disease.Sea-buckthorn product and compound formulation thereof are mainly used in the treatment cardiovascular and cerebrovascular disease, improve immunity, the anti-ageing aspect of waiting for a long time, and rhodiola root product and compound formulation thereof then are mainly used in and regulate body function, improve aspects such as body immunity, antifatigue.Existing anti-fatigue product is made up of multiple plant extracts with anti-fatigue effect mostly, at least five, six kind of plant, tens kinds even 20 various plants at most; It is believed that the antifatigue composition in the product is many more, antifatigue effect is comprehensive more, and the antifatigue effect is good more; But character and effect are not quite similar between the various extracts; The human body constitution and the reason that produces fatigue of each self application are arranged, put these antifatigue compositions together, the antifatigue effect is unsatisfactory; And owing to contain multiple composition, complex production process.
Summary of the invention
The invention discloses a kind of big fruit sea-buckthorn compound fatigue-resistant powder and preparation method thereof, solved and contained the various plants extract in the existing anti-fatigue product, the antifatigue effect is undesirable, and owing to contains multiple composition, the problem of complex production process.
Big fruit sea-buckthorn compound fatigue-resistant powder is processed by 85%～95% big fruit sea-buckthorn pulp and 5%～15% gadol extract by mass percent.Flavones content in per 100 gram big fruit sea-buckthorn compound fatigue-resistant powders is 600mg, and rhodioside content is 20mg.
Big fruit sea-buckthorn compound fatigue-resistant powder prepares according to the following steps:
1) preparation big fruit sea-buckthorn pulp: earlier the big fruit sea-buckthorn fresh fruit is soaked in water; Clean, remove the impurity and the fruits of rotting such as cauline leaf, again that the big fruit sea-buckthorn fresh fruit is broken, cross 60 mesh sieves; Big fruit sea-buckthorn pulp after will filtering then grinds 3～5min with colloid mill; Use centrifuge with the centrifugal 8～12min of the speed of 3000r/min at last, remove lower sediment, it is subsequent use to obtain upper strata big fruit sea-buckthorn pulp;
2) preparation gadol extract: take by weighing rhodiola root dry rhizome fine powder; With the solid-liquid ratio is the ethanolic solution of the ratio adding mass concentration 60%～80% of 1g:20mL～1g:40mL; With lixiviate 8～12 hours in 40 ℃ of water-baths again behind ultrasonic wave lixiviate 20～30min, filter then, repeat to extract 3 times; Merge extract and concentrated, it is subsequent use to get gadol extract;
3) mass percent by the gadol extract of 85%～95% big fruit sea-buckthorn pulp and 5%～15% mixes big fruit sea-buckthorn pulp and gadol extract; With homogenizer homogeneous 8～12min under the 40MPa condition; Use then freeze dryer under 0.4～0.7mbar, temperature-30 ℃ condition with big fruit sea-buckthorn pulp and gadol extract mixture vacuum freeze-drying 24 hours and be ground into 60 order powder, promptly get big fruit sea-buckthorn compound fatigue-resistant powder.
The big fruit sea-buckthorn fatigue-resistant powder can be processed various formulations such as capsule, tablet.
The present invention carries out scientific and reasonable compatibility with big fruit sea-buckthorn and rhodiola root; Make the two act on target spots different in the body, form many target spot mechanism, thereby produce good antifatigue effect; Compare with other natural extract anti-fatigue product, big fruit sea-buckthorn compound fatigue-resistant powder has following advantage:
1. scientific formulation is reasonable: product of the present invention is an index with flavones and rhodioside content, according to the intake preparation of zoopery optimum efficiency.Can not only bring into play the optimal efficacy of big fruit sea-buckthorn antifatigue compound formulation, and guarantee its security.
2. big fruit sea-buckthorn pulp and the gadol extract in the big fruit sea-buckthorn antifatigue compound formulation has synergy, and they act on the different target spots of body, obtain good antifatigue effect.Zoopery is the result show; Big fruit sea-buckthorn antifatigue compound formulation antifatigue effect is superior to taking separately big fruit sea-buckthorn pulp and gadol extract; The big fruit sea-buckthorn pulp and the gadol extract that also are superior to containing the multicomponent compound of sea-buckthorn, gadol extract and take Isodose sequentially, its above test group of pole-climbing time has prolonged 88%, 58%, 35.1% and 18.8% respectively, and the swimming with a load attached to the body time is respectively 3.5 times of blank control group; 2.47 times of sea-buckthorn group; 1.9 times of rhodiola root group, 1.47 times of multicomponent control group, 1.3 times of feeding sea-buckthorn, rhodiola root group in order.This is because after big fruit sea-buckthorn pulp and gadol extract process big fruit sea-buckthorn antifatigue composite powder; Flavonoid substances wherein and rhodioside and other active ingredient merge each other; Mutually promote: the big fruit sea-buckthorn pulp hemoglobin that can raise. increase lung capacity, eliminate lactic acid in the blood, improve body oxygen supply function; Depleted musculature is recovered normally, and the anoxic venereal disease of the disorderly appearance of physiological function that the excessive lactic acid of a large amount of motion generations of special adaptation causes is rational tired; Rhodiola root can increase the duration of brain and human body normal activity; Prolong the load-bearing capacity of cerebral nerve and body muscle; Can strengthen the utilization rate of oxygen; The content of lactic acid and acetone in the reduction blood, the oxygen demand of reduction muscle: during overwork, the decomposition that can quicken fat and protein increases the transmission of energy; After the overwork, can increase the deposit of inose unit and liver glycogen again.They all have the effect that improves immunocompetence, cardiac stimulant, anti-anoxic, antifatigue, meet the relation of the traditional Chinese medicine compatibility of drugs mutual-assistance.
3. application range of products is wide.The present invention has processed fatigue-resistant powder with big fruit sea-buckthorn pulp and gadol extract, because big fruit sea-buckthorn and rhodiola root all belong to medicine food dual purpose plant, the effect that human body is produced does not have physical difference, is fit to various crowds.
4. production technology of the present invention is simple, with low cost, economic benefit is good, is easy to promote.
5. the present invention adopts vacuum freeze drying technology, and operation is operation at low temperatures, has kept the effective active composition in big fruit sea-buckthorn and the rhodiola root greatly, can be used as health medicine and nutraceutical.
The specific embodiment
The specific embodiment one: big fruit sea-buckthorn compound fatigue-resistant powder is processed by 85%～95% big fruit sea-buckthorn pulp and 5%～15% gadol extract by mass percent in this specific embodiment.
The specific embodiment two: what this specific embodiment and the specific embodiment one were different is: the flavones content in per 100 gram big fruit sea-buckthorn compound fatigue-resistant powders is 600mg, and rhodioside content is 20mg.Other is identical with the specific embodiment one.
The specific embodiment three: big fruit sea-buckthorn compound fatigue-resistant powder prepares according to the following steps in this specific embodiment:
1) preparation big fruit sea-buckthorn pulp: earlier the big fruit sea-buckthorn fresh fruit is soaked in water; Clean, remove the impurity and the fruits of rotting such as cauline leaf, again that the big fruit sea-buckthorn fresh fruit is broken, cross 60 mesh sieves; Big fruit sea-buckthorn pulp after will filtering then grinds 3～5min with colloid mill; Use centrifuge with the centrifugal 8～12min of the speed of 3000r/min at last, remove lower sediment, it is subsequent use to obtain upper strata big fruit sea-buckthorn pulp;
2) preparation gadol extract: take by weighing rhodiola root dry rhizome fine powder; With the solid-liquid ratio is the ethanolic solution of the ratio adding mass concentration 60%～80% of 1g:20mL～1g:40mL; With lixiviate 8～12 hours in 40 ℃ of water-baths again behind ultrasonic wave lixiviate 20～30min, filter then, repeat to extract 3 times; Merge extract and concentrated, it is subsequent use to get gadol extract;
3) mass percent by the gadol extract of 85%～95% big fruit sea-buckthorn pulp and 5%～15% mixes big fruit sea-buckthorn pulp and gadol extract; With homogenizer homogeneous 8～12min under the 40MPa condition; Use then freeze dryer under 0.4～0.7mbar, temperature-30 ℃ condition with big fruit sea-buckthorn pulp and gadol extract mixture vacuum freeze-drying 24 hours and be ground into 60 order powder, promptly get big fruit sea-buckthorn compound fatigue-resistant powder.
The specific embodiment four: big fruit sea-buckthorn compound fatigue-resistant powder is processed by 85%～95% big fruit sea-buckthorn pulp and 5%～15% gadol extract by mass percent in this specific embodiment.And preparation according to the following steps:
1) preparation big fruit sea-buckthorn pulp: earlier the big fruit sea-buckthorn fresh fruit is soaked in water; Clean, remove the impurity and the fruits of rotting such as cauline leaf, again that the big fruit sea-buckthorn fresh fruit is broken, cross 60 mesh sieves; Big fruit sea-buckthorn pulp after will filtering then grinds 3～5min with colloid mill; Use centrifuge with the centrifugal 8～12min of the speed of 3000r/min at last, remove lower sediment, it is subsequent use to obtain upper strata big fruit sea-buckthorn pulp;
2) preparation gadol extract: take by weighing rhodiola root dry rhizome fine powder; With the solid-liquid ratio is the ethanolic solution of the ratio adding mass concentration 60%～80% of 1g:20mL～1g:40mL; With lixiviate 8～12 hours in 40 ℃ of water-baths again behind ultrasonic wave lixiviate 20～30min, filter then, repeat to extract 3 times; Merge extract and concentrated, it is subsequent use to get gadol extract;
3) mass percent by the gadol extract of 85%～95% big fruit sea-buckthorn pulp and 5%～15% mixes big fruit sea-buckthorn pulp and gadol extract; With homogenizer homogeneous 8～12min under the 40MPa condition; Use then freeze dryer under 0.4～0.7mbar, temperature-30 ℃ condition with big fruit sea-buckthorn pulp and gadol extract mixture vacuum freeze-drying 24 hours and be ground into 60 order powder, promptly get big fruit sea-buckthorn compound fatigue-resistant powder.
Wherein, the flavones content in per 100 gram big fruit sea-buckthorn compound fatigue-resistant powders is 600mg, and rhodioside content is 20mg.
The specific embodiment five: big fruit sea-buckthorn compound fatigue-resistant powder is processed by 95% big fruit sea-buckthorn pulp and 5% gadol extract by mass fraction in this specific embodiment.Preparation according to the following steps:
1) preparation big fruit sea-buckthorn pulp: earlier the big fruit sea-buckthorn fresh fruit is soaked in water; Clean, remove the impurity and the fruits of rotting such as cauline leaf, again that the big fruit sea-buckthorn fresh fruit is broken, cross 60 mesh sieves; Big fruit sea-buckthorn pulp after will filtering then grinds 3min with colloid mill; Use centrifuge with the centrifugal 10min of the speed of 3000r/min at last, remove lower sediment, it is subsequent use to obtain upper strata big fruit sea-buckthorn pulp;
2) preparation gadol extract: take by weighing rhodiola root dry rhizome fine powder; With the solid-liquid ratio is the ethanolic solution of the ratio adding mass concentration 70% of 1g:20mL～1g:40mL; With lixiviate 12 hours in 40 ℃ of water-baths again behind the ultrasonic wave lixiviate 30min, filter then, repeat to extract 3 times; Merge extract and concentrated, it is subsequent use to get gadol extract;
3) mass percent by the gadol extract of 95% big fruit sea-buckthorn pulp and 5% mixes big fruit sea-buckthorn pulp and gadol extract; With homogenizer homogeneous 10min under the 40MPa condition; Use then freeze dryer under 0.4～0.7mbar, temperature-30 ℃ condition with big fruit sea-buckthorn pulp and gadol extract mixture vacuum freeze-drying 24 hours and be ground into 60 order powder, promptly get big fruit sea-buckthorn compound fatigue-resistant powder.
Wherein, the flavones content in per 100 gram big fruit sea-buckthorn compound fatigue-resistant powders is 600mg, and rhodioside content is 20mg.
The big fruit sea-buckthorn compound fatigue-resistant powder that obtains with this specific embodiment is done the superiority of its antifatigue of animal experiment explanation, and with the single big fruit sea-buckthorn pulp of feeding, single gadol extract, feeding contain the multicomponent compound of sea-buckthorn and rhodiola root and in order the mouse of feeding sea-buckthorn, gadol extract make comparisons.All tests are all carried out according to Ministry of Public Health's alleviating physical fatigue functional check method: with body weight is 18 ± 3g, and the Kunming mouse of male and female half and half is divided into 6 groups at random, 16 every group.Every group of mouse continuous irrigation fed 28d and tried thing; Blank control group is fed distilled water; Sea-buckthorn group feeding big fruit sea-buckthorn pulp 63.0g/kg.bw every day; Rhodiola root group feeding every day gadol extract 3.0g/kg.bw, multicomponent control group feeding every day contain the product (application number: 200710050065.7) 15.0g/kg.bw, feeding sea-buckthorn, rhodiola root group elder generation's every day hello 63.0g/kg.bw big fruit sea-buckthorn pulp in order of rhodiola root, sea-buckthorn, sealwort, genseng, Fructus chebulae immaturus composition; Feed gadol extract 3.0g/kg.bw, the big fruit sea-buckthorn compound fatigue-resistant powder 66.0g/kg.bw of this specific embodiment of big fruit sea-buckthorn composite powder group feeding after 1 hour again.The result is following:
Big fruit sea-buckthorn compound fatigue-resistant powder is to the influence of mouse pole-climbing time:
Method: adopt the pole-climbing frame that is about 1 meter vertically to place the pond of 25 ℃ of water temperatures, about deeply 30cm.Last is tried begins experiment behind the thing 30min; Mouse is placed on the iron staff of certain degree of roughness, makes mouse muscle be in the static(al) tense situation, the record mouse is because the unable iron staff of embracing of muscular fatigue; Fall the time the pond from iron staff; Stop experiment when falling into water for the third time, the average time that accumulative total is three times, result of the test was as shown in table 1 as the pole-climbing time.
Can find out by table 1; The pole-climbing time of big fruit sea-buckthorn antifatigue composite powder group mouse is the longest; Than blank control group time lengthening 239.29%, the pole-climbing time is 1.88 times of sea-buckthorn group, is 1.58 times of rhodiola root group; Being 1.35 times of multicomponent control group, is feeding sea-buckthorn, rhodiola root group 1.18 times in order.
Table 1 big fruit sea-buckthorn compound fatigue-resistant powder is to the influence of mouse pole-climbing time (n=16, x ± s)
Rate elongation (%)=(experimental group-blank control group) ÷ blank control group * 100
Big fruit sea-buckthorn compound fatigue-resistant powder is to the influence of mouse swimming with a load attached to the body time:
Method: the mouse continuous irrigation is fed 28d and is tried thing; After last is irritated and is fed 30min; With the bear a heavy burden galvanized wire of 3% body weight of mouse tail, place the swimming pool of 60cm * 40cm * 50cm to swim, 30 ± 1 ℃ of water temperatures; The record mouse begins to swim to power and exhausts the time of sinking to till underwater 8s can not emerge, and the power that is mouse exhausts swimming time.Result of the test is as shown in table 2.
Table 2 big fruit sea-buckthorn compound fatigue-resistant powder is to the influence of mouse swimming with a load attached to the body time (n=16, x ± s)
Rate elongation (%)=(experimental group-blank control group) ÷ blank control group * 100
Can be found out that by table 2 the swimming with a load attached to the body time of big fruit sea-buckthorn compound fatigue-resistant powder is the longest, be 3.5 times of blank control group; 2.47 times of sea-buckthorn group; Being 1.9 times of rhodiola root group, is 1.47 times of multicomponent control group, is feeding sea-buckthorn, rhodiola root group 1.3 times in order.
Mouse pole-climbing experiment and swimming with a load attached to the body experiment show that feeding big fruit sea-buckthorn antifatigue composite powder can effectively prolong pole-climbing time and the swimming with a load attached to the body time of mouse, increase exercise tolerance, show good antifatigue effect.
Big fruit sea-buckthorn compound fatigue-resistant powder is to the influence of mouse blood lactic acid (BLA) and serum urea nitrogen (BUN):
Method: the mouse continuous irrigation is fed 28d and is tried thing, and last places not swimming with a load attached to the body of swimming pool 30min with mouse, 30 ± 1 ℃ of water temperatures after irritating and feeding 30min.Swimming back 30min eyeball is got blood, measures the content of mouse BLA and BUN.
Table 3 big fruit sea-buckthorn compound fatigue-resistant powder is to the influence of mouse blood lactic acid (BLA) and serum urea nitrogen (BUN) (n=16, x ± s)
Table 3 is big fruit sea-buckthorn compound fatigue-resistant powder influences to mouse blood lactic acid (BLA) and serum urea nitrogen (BUN).Can find out by table 3; Behind swimming 30min; Each serum lactic acid value of organizing mouse all increases substantially before the swimming; But the BLA and the BUN content of big fruit sea-buckthorn antifatigue composite powder group are starkly lower than other test group, and its BLA content is merely 0.26 times of blank control group, and BUN content is 0.39 times of blank control group.Blood lactic acid (BLA) and serum urea nitrogen (BUN) are the metabolites that produces behind the body movement; Also be to cause body to produce tired material; And big fruit sea-buckthorn compound fatigue-resistant powder can obviously reduce the existence of this material in body; Reducing sense of fatigue or delay fatigue sense, is a kind of effective anti-fatigue product.Big fruit sea-buckthorn compound fatigue-resistant powder is to the influence of Mouse Liver glycogen (LG) and muscle glycogen (MG):
Method: the mouse continuous irrigation is fed 28d and is tried thing, and last places not swimming with a load attached to the body of swimming pool 30min with mouse, 30 ± 1 ℃ of water temperatures after irritating and feeding 30min.Mouse respectively behind swimming 30min eyeball get blood, take off cervical vertebra then and put to death, take out liver and back leg muscle immediately, measure the content of LG and MG respectively.
Table 4 is the influences to Mouse Liver glycogen (LG) and muscle glycogen (MG) of big fruit sea-buckthorn compound formulation.Can find out that by table 4 hepatic glycogen of big fruit sea-buckthorn compound fatigue-resistant powder group and muscle glycogen content are apparently higher than other control group.Hepatic glycogen and muscle glycogen be storage power material, for various vital movements provide energy, what of their content directly influence the locomitivity of body.The interior glycogen of liver and muscle not only is higher than the blank group far away in the compound formulation group; And be higher than feeding sea-buckthorn, rhodiola root group in order; Its content feeding sea-buckthorn, rhodiola root component more in order you can well imagine high 23% and 16%; The big fruit sea-buckthorn compound fatigue-resistant powder of this this prepared of explanation can significantly improve Mouse Liver glycogen (LG) and muscle glycogen (MG) deposit, thus alleviating fatigue.
Table 4 big fruit sea-buckthorn compound formulation is to the influence of Mouse Liver glycogen (LG) and muscle glycogen (MG)
( mg/g，，n＝16，x±s)
Above animal experimental data shows: big fruit sea-buckthorn compound fatigue-resistant powder can significantly improve pole-climbing time and the swimming with a load attached to the body time of mouse, explains that big fruit sea-buckthorn compound fatigue-resistant powder has the effect that improves mouse movement endurance, antifatigue.Big fruit sea-buckthorn compound fatigue-resistant powder can obviously reduce BLA and BUN content behind the mouse movement; Improve hepatic glycogen (LG) and muscle glycogen (MG) deposit; Explained the reason of big fruit sea-buckthorn compound fatigue-resistant powder to body generation antifatigue effect from the physiology aspect; Explain that big fruit sea-buckthorn compound fatigue-resistant powder produces antifatigue effect through regulating body function, for keep the body eubolism, the energy i (in vivo) reserve supply is piled up, increased to less metabolite that positive role is arranged, human body is safe from harm.Separately result of use is better sequentially than using wherein a kind of component or two kinds of components for the big fruit sea-buckthorn compound fatigue-resistant powder that the present invention makes; After having proved that big fruit sea-buckthorn and rhodiola extract are through composite, mixing, vacuum freeze-drying processing technology; Big fruit sea-buckthorn pulp and gadol extract can produce synergy, obtain good antifatigue effect.Show with the contrast of multicomponent control group test; Product of the present invention is more better than the antifatigue effect that contains the composite product of sea-buckthorn, rhodiola root, sealwort, genseng, these components of Fructus chebulae immaturus; This wherein possible reason is that multiple extract has produced partial antagonism after composite, causes the antifatigue effect undesirable.
Claims (3)
1. big fruit sea-buckthorn compound fatigue-resistant powder is characterized in that big fruit sea-buckthorn compound fatigue-resistant powder processed by 85%～95% big fruit sea-buckthorn pulp and 5%～15% gadol extract by mass percent;
Described big fruit sea-buckthorn pulp preparation method is following: earlier the big fruit sea-buckthorn fresh fruit is soaked in water; Clean, remove the impurity and the fruit of rotting, again that the big fruit sea-buckthorn fresh fruit is broken, cross 60 mesh sieves; Big fruit sea-buckthorn pulp after will filtering then grinds 3～5min with colloid mill; Use centrifuge with the centrifugal 8～12min of the speed of 3000r/min at last, remove lower sediment, it is subsequent use to obtain upper strata big fruit sea-buckthorn pulp;
Described gadol extract preparation method is following: take by weighing rhodiola root dry rhizome fine powder; With the solid-liquid ratio is the ethanolic solution of the ratio adding mass concentration 60%～80% of 1g: 20mL～1g: 40mL; With lixiviate 8～12 hours in 40 ℃ of water-baths again behind ultrasonic wave lixiviate 20～30min, filter then, repeat to extract 3 times; Merge extract and concentrated, it is subsequent use to get gadol extract;
Described big fruit sea-buckthorn compound fatigue-resistant powder preparation method is following: the mass percent of big fruit sea-buckthorn pulp by 85%～95% and 5%～15% gadol extract mixes big fruit sea-buckthorn pulp and gadol extract; With homogenizer homogeneous 8～12min under the 40MPa condition; Then with freeze dryer under 0.4～0.7mbar, temperature-30 ℃ condition with big fruit sea-buckthorn pulp and gadol extract mixture vacuum freeze-drying 24 hours and be ground into 60 order powder, promptly get big fruit sea-buckthorn compound fatigue-resistant powder.
2. big fruit sea-buckthorn compound fatigue-resistant powder according to claim 1 is characterized in that the flavones content in per 100 gram big fruit sea-buckthorn compound fatigue-resistant powders is 600mg, and rhodioside content is 20mg.
3. the method for preparing the described big fruit sea-buckthorn compound fatigue-resistant powder of claim 1 is characterized in that big fruit sea-buckthorn compound fatigue-resistant powder prepares according to the following steps:
1) preparation big fruit sea-buckthorn pulp: earlier the big fruit sea-buckthorn fresh fruit is soaked in water; Clean, remove the impurity and the fruit of rotting, again that the big fruit sea-buckthorn fresh fruit is broken, cross 60 mesh sieves; Big fruit sea-buckthorn pulp after will filtering then grinds 3～5min with colloid mill; Use centrifuge with the centrifugal 8～12min of the speed of 3000r/min at last, remove lower sediment, it is subsequent use to obtain upper strata big fruit sea-buckthorn pulp;
2) preparation gadol extract: take by weighing rhodiola root dry rhizome fine powder; With the solid-liquid ratio is the ethanolic solution of the ratio adding mass concentration 60%～80% of 1g: 20mL～1g: 40mL; With lixiviate 8～12 hours in 40 ℃ of water-baths again behind ultrasonic wave lixiviate 20～30min, filter then, repeat to extract 3 times; Merge extract and concentrated, it is subsequent use to get gadol extract;
3) mass percent by the gadol extract of 85%～95% big fruit sea-buckthorn pulp and 5%～15% mixes big fruit sea-buckthorn pulp and gadol extract; With homogenizer homogeneous 8～12min under the 40MPa condition; Then with freeze dryer under 0.4～0.7mbar, temperature-30 ℃ condition with big fruit sea-buckthorn pulp and gadol extract mixture vacuum freeze-drying 24 hours and be ground into 60 order powder, promptly get big fruit sea-buckthorn compound fatigue-resistant powder.
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| CN107594598A (en) * | 2017-08-22 | 2018-01-19 | 汪保华 | A kind of processing method of gumbo corn flower nutrient powder |
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| CN109170888A (en) * | 2018-09-18 | 2019-01-11 | 广东时代食品与生命健康研究有限公司 | A kind of anti-oxidant, anti-Fatigue Composition and preparation method thereof |
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