CN102451260A - Traditional Chinese medicine composition with function of alleviating fatigue and preparation method thereof - Google Patents
Traditional Chinese medicine composition with function of alleviating fatigue and preparation method thereof Download PDFInfo
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- CN102451260A CN102451260A CN2010105295010A CN201010529501A CN102451260A CN 102451260 A CN102451260 A CN 102451260A CN 2010105295010 A CN2010105295010 A CN 2010105295010A CN 201010529501 A CN201010529501 A CN 201010529501A CN 102451260 A CN102451260 A CN 102451260A
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Abstract
The invention relates to a traditional Chinese medicine composition with a function of alleviating fatigue and a preparation method, and belongs to the technical field of traditional Chinese preparation. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 2-9 parts of morindae radix, 1-6 parts of rhodiola rosea and 1-6 parts of American ginseng. The preparation method comprises the steps of: extracting morindae radix and rhodiola rosea with ethanol, drying extract liquid to a certain concentration to obtain extract, crushing American ginseng, combining with the extract and preparing into various pharmaceutical dosage forms. The product produced according to the preparation method provided by the invention has obvious action of alleviating fatigue, and has good mouthfeel, safety and no toxic or side effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition with function of alleviating fatigue and preparation method thereof, said compositions both can be made into medicine, can be made into health food again, belonged to the Chinese medicine preparation technical field.
Background technology
Fatigue is meant that the physiological process of body can not remain on a specified level and/or each organ can not keep its predetermined exercise intensity the time with its function, is called " fatigue ".Fatigue is the temporary transient decline of the original function of body, is again the tendency that body develops into morbid state.
Along with the high speed development of modern society, the quickening of study and work rhythm of life, people are more and more in the face of the pressure of each side; Fatigue phenomenon is also more and more general; Receive the people of tired puzzlement also more and more, fatigue has had a strong impact on people's work efficient and quality of life, how to prevent and allaying tiredness; Cause that people pay close attention to, and become and press for.The health product of fatigue alleviating receive people's favor gradually because of having health care, prevention and function of alleviating fatigue.The raw material sources of China's fatigue alleviating health food are mainly nutrient (sugar, protein, aminoacid, vitamin, inorganic salt etc.) and Chinese herbal medicine at present, and nutrient is used for sports drink and motion supplement more; With the Chinese herbal medicine is the product of raw material, meets the traditional health preserving idea of China, and the scope of application is wider.
Summary of the invention
The present invention aims to provide a kind of Chinese medicine composition with function of alleviating fatigue, both can be made into medicine, can be made into health food again, satisfies people to this type of product demand.
Another important content of the present invention has provided the method for preparing of above-mentioned Chinese medicine composition.
The present invention realizes through following technical scheme:
Described Chinese medicine composition with function of alleviating fatigue is processed by following raw medicaments in portion by weight: Radix Morindae Officinalis 2-9 part, Radix Rhodiolae 1-6 part, Radix Panacis Quinquefolii 1-6 part.
It is to be processed by following raw medicaments in portion by weight that above-mentioned Chinese medicine composition is preferably filled a prescription: 3 parts of Radix Morindae Officinaliss, 2 parts of Radix Rhodiolaes, 1 part of Radix Panacis Quinquefolii.
Above-mentioned Chinese medicine composition can be made into tablet, capsule or granule.
The method for preparing of above-mentioned Chinese medicine composition, adopt following steps:
A. Radix Rhodiolae was pulverized 10～60 mesh sieves; Radix Morindae Officinalis is pulverized and is not sieved, and gets Radix Morindae Officinalis and Radix Rhodiolae powder by formula proportion, and the percent by volume that dosing material amount is 6～12 times is 0%～90% ethanol water; Heating and refluxing extraction 1～3 time, each extraction time is 0.5～2 hour;
B. merge extractive liquid, reclaims ethanol and concentrates, to the extractum relative density be 1.33-1.35 (50-60 ℃), obtain extract;
C. get the Radix Panacis Quinquefolii powder of 60-120 mesh sieve by formula proportion, added adjuvant, made product.
Preferably adopt following processing step preparation:
A. Radix Rhodiolae was pulverized 30 mesh sieves, and Radix Morindae Officinalis is pulverized and do not sieved, and gets Radix Morindae Officinalis and Radix Rhodiolae powder by formula proportion, and the percent by volume that dosing material amount is 8 times is 60% ethanol water, heating and refluxing extraction 3 times, and each extraction time is 1.5 hours.
B. merge extractive liquid, reclaims ethanol and concentrates, to the extractum relative density be 1.34 (50-60 ℃), obtain extract;
C. get the Radix Panacis Quinquefolii powder of 100 mesh sieves by formula proportion, added adjuvant, made product.
The extracts active ingredients of each raw material of product that the above-mentioned technology of foundation makes is more abundant; Can in existing industrial manufacture process, keep effective ingredient to greatest extent; Consider that simultaneously Radix Panacis Quinquefolii is a rare Chinese medicine, and consumption is less in the side, it is directly pulverized the back directly add; Not only can reduce loss of active ingredients but also can serve as filler, kill two birds with one stone.
The present invention prescription is brand-new, Radix Morindae Officinalis warming the kidney to activate YANG, strong muscles and bones,, benefiting essence-blood, Radix Rhodiolae invigorating the spleen and benefiting QI, lung heat clearing, invigorate blood circulation the Radix Panacis Quinquefolii boosting qi and nourishing yin; Relieve inflammation or internal heat and promote the production of body fluid, the three share invigorating the spleen and benefiting QI, Yin-nourishing and body fluid promoting, the kidney warming replenishing essence.And modern study also shows the ginsenoside in the Radix Panacis Quinquefolii, and the rhodioside in the Radix Rhodiolae, butyl alcohol, polysaccharide, the polysaccharide in the Radix Morindae Officinalis can both human body immunity improving power, delay fatigue.Method for preparing adopts the scientific method effective component extracting, makes with modern preparation technique.Dose is few, and effect is remarkable, safe without toxic side effect, and mouthfeel is fine
A kind of Chinese medicine composition and method for preparing with function of alleviating fatigue of the present invention is to be based upon on the scientific experiments basis, and production technology is simple, steady quality, and effect is reliable.
The specific embodiment
Through specific embodiment the present invention is further described below.
Embodiment 1
The prescription of Chinese medicine composition of the present invention is: Radix Morindae Officinalis 2g, Radix Rhodiolae 1g, Radix Panacis Quinquefolii 1.5g.
Method for preparing: get above-mentioned medicinal materials in part by weight, Radix Rhodiolae was pulverized 10 mesh sieves, and Radix Panacis Quinquefolii was pulverized 100 mesh sieves, and Radix Morindae Officinalis is pulverized and do not sieved.Radix Morindae Officinalis is mixed with Radix Rhodiolae, and the water that adds 6 times of amounts refluxes and carries each 0.5 hour 3 times.Extracting solution is reclaimed ethanol and is concentrated into relative density 1.34 (50-60 ℃), add Radix Panacis Quinquefolii powder, added the dextrin of 100 mesh sieves, add an amount of aspartame; With 60% ethanol is wetting agent, crosses 20 mesh sieves and granulates 60 ℃ of dryings; Cross 20 mesh sieve granulate, 60 mesh sieves sieve removes fine powder, processes granule.
Embodiment 2
The prescription of Chinese medicine composition of the present invention is: Radix Morindae Officinalis 2g, Radix Rhodiolae 1g, Radix Panacis Quinquefolii 1.5g.
Method for preparing: get above-mentioned medicinal materials in part by weight, Radix Rhodiolae was pulverized 10 mesh sieves, and Radix Panacis Quinquefolii was pulverized 100 mesh sieves, and Radix Morindae Officinalis is pulverized and do not sieved.Radix Morindae Officinalis is mixed with Radix Rhodiolae, and the water that adds 6 times of amounts refluxes and carries each 0.5 hour 3 times.Extracting solution is reclaimed ethanol and is concentrated into relative density 1.34 (50-60 ℃), add Radix Panacis Quinquefolii powder, added the mannitol of 60 mesh sieves, add an amount of aspartame; With 60% ethanol is wetting agent, crosses 20 mesh sieves and granulates 60 ℃ of dryings; Cross 20 mesh sieve granulate, 60 mesh sieves sieve removes fine powder, processes granule.
Embodiment 3
The prescription of Chinese medicine composition of the present invention is: Radix Morindae Officinalis 9g, Radix Rhodiolae 6g, Radix Panacis Quinquefolii 6g.
Method for preparing: get above-mentioned medicinal materials in part by weight, Radix Rhodiolae was pulverized 20 mesh sieves, and Radix Panacis Quinquefolii was pulverized 100 mesh sieves, and Radix Morindae Officinalis is pulverized and do not sieved.Radix Morindae Officinalis is mixed with Radix Rhodiolae, add 90% alcohol reflux 3 times of 8 times of amounts, each 1 hour.Extracting solution is reclaimed ethanol and is concentrated into relative density 1.34 (50-60 ℃), add Radix Panacis Quinquefolii powder, added the dextrin of 100 mesh sieves; With 60% ethanol is wetting agent, crosses 20 mesh sieves and granulates 60 ℃ of dryings; Cross 20 mesh sieve granulate, 60 mesh sieves sieve removes fine powder, processes granule.
The granule dissolubility that makes with this method is good, and no sucrose is fit to the diabetes patient and uses.And this granule compressibility is fabulous, and the tablet that makes is unilateral level and smooth, and mouthfeel is good.
Embodiment 4
The prescription of Chinese medicine composition of the present invention is: Radix Morindae Officinalis 4.5g, Radix Rhodiolae 3g, Radix Panacis Quinquefolii 1.5g.
Method for preparing: get above-mentioned medicinal materials in part by weight, Radix Rhodiolae was pulverized 30 mesh sieves, and Radix Panacis Quinquefolii was pulverized 100 mesh sieves, and Radix Morindae Officinalis is pulverized and do not sieved.Radix Morindae Officinalis is mixed with Radix Rhodiolae, add 60% alcohol reflux 3 times of 10 times of amounts, each 1.5 hours.Extracting solution is reclaimed ethanol and is concentrated into relative density 1.34 (50-60 ℃), add Radix Panacis Quinquefolii powder, added the starch of 100 mesh sieves, add an amount of aspartame; With 60% ethanol is wetting agent, crosses 20 mesh sieves and granulates 60 ℃ of dryings; Cross 20 mesh sieve granulate, 60 mesh sieves sieve removes fine powder, processes granule.
Embodiment 5
The prescription of Chinese medicine composition of the present invention is: Radix Morindae Officinalis 4.5g, Radix Rhodiolae 3g, Radix Panacis Quinquefolii 1.5g.
Method for preparing: get above-mentioned medicinal materials in part by weight, Radix Rhodiolae was pulverized 60 mesh sieves, and Radix Panacis Quinquefolii was pulverized 100 mesh sieves, and Radix Morindae Officinalis is pulverized and do not sieved.Radix Morindae Officinalis is mixed with Radix Rhodiolae, add 60% alcohol reflux 3 times of 8 times of amounts, each 1.5 hours.Extracting solution is reclaimed ethanol and is concentrated into relative density 1.34 (50-60 ℃), add Radix Panacis Quinquefolii powder, added the dextrin of 100 mesh sieves, add an amount of aspartame; With 60% ethanol is wetting agent, crosses 20 mesh sieves and granulates 60 ℃ of dryings; Cross 20 mesh sieve granulate, 60 mesh sieves sieve removes fine powder, processes granule.
Embodiment 6
The prescription of Chinese medicine composition of the present invention is: Radix Morindae Officinalis 3g, Radix Rhodiolae 2g, Radix Panacis Quinquefolii 1g.
Method for preparing: get above-mentioned medicinal materials in part by weight, Radix Rhodiolae was pulverized 30 mesh sieves, and Radix Panacis Quinquefolii was pulverized 100 mesh sieves, and Radix Morindae Officinalis is pulverized and do not sieved.Radix Morindae Officinalis is mixed with Radix Rhodiolae, and dosing material amount 6-8 percent by volume doubly is 60% ethanol water, heating and refluxing extraction 3 times, and each extraction time is 1.5 hours.Wherein extract the 8 times of amounts of people that add for the first time, the 6 times of amounts that add are extracted in second and third time.Extracting solution is reclaimed ethanol and is concentrated into relative density 1.34 (50-60 ℃), add Radix Panacis Quinquefolii powder, added the starch of 100 mesh sieves, add an amount of aspartame; With 60% ethanol is wetting agent, crosses 20 mesh sieves and granulates 60 ℃ of dryings; Cross 20 mesh sieve granulate, 60 mesh sieves sieve removes fine powder, processes granule.
Embodiment 7
The gained granule does not add aspartame among the embodiment 1,2,3,4,5, incapsulates, and processes capsule.
Embodiment 8
Get gained granule among the embodiment 1,2,3,4,5, be sieved into an amount of magnesium stearate, mix homogeneously, the pressure tabletting is fitted in blending, processes tablet.
Embodiment 9
The prescription of Chinese medicine composition of the present invention is: Radix Morindae Officinalis 3g, Radix Rhodiolae 2g, Radix Panacis Quinquefolii 1g.
Method for preparing: get above-mentioned medicinal materials in part by weight, Radix Rhodiolae was pulverized 30 mesh sieves, and Radix Panacis Quinquefolii was pulverized 100 mesh sieves, and Radix Morindae Officinalis is pulverized and do not sieved.Radix Morindae Officinalis is mixed with Radix Rhodiolae, and dosing material amount 6-8 percent by volume doubly is 60% ethanol water, heating and refluxing extraction 3 times, and each extraction time is 1.5 hours.Wherein extract the 8 times of amounts of people that add for the first time, the 6 times of amounts that add are extracted in second and third time.Extracting solution is reclaimed ethanol and is concentrated into relative density 1.34 (50-60 ℃); Add Radix Panacis Quinquefolii powder, added microcrystalline Cellulose, mannitol, the lactose of 100 mesh sieves, add an amount of aspartame, citric acid; With 60% ethanol is wetting agent; Cross 20 mesh sieves and granulate, spray into an amount of Mentholum 30ml, coffee aroma, low-temperature aeration is dry; Be sieved into an amount of magnesium stearate, mix homogeneously, the pressure tabletting is fitted in blending, processes chewable tablet or buccal tablet.
The pharmacological evaluation data
Medicine with embodiment 6 preparations experimentizes.
The pharmacodynamics test method:
Mice swimming with a load attached to the body test test material:
60 of SPF level kunming mices, body weight 18～22g (providing), sample (self-control), gold day Radix Panacis Quinquefolii buccal tablets (Xiamen Jinri Pharmaceutical Co., Ltd) by Traditional Chinese Medicine University Of Guangzhou's Experimental Animal Center.
Method:
With mice by dividing 5 experimental grouies at random, i.e. normal control group, high, medium and low dose groups, positive controls, 12 every group.Each treated animal is irritated stomach every day and is given corresponding medicinal liquid or equal-volume distilled water 1 time, and continuous 15 days, after last is irritated stomach 30min; Mice is put into the swimming case; Depth of water 35cm, 25 ℃ of water temperatures, the load lead of 10% mice body weight of Mus root of the tail portion; Mice begins to a time that submerged 10s can not float, as the swimming time of mice from swimming record.The result sees table 1.
The result: 3 dose groups mice swimming with a load attached to the body times of the present invention are all apparently higher than shining group, wherein high dose group
*There is significant differences P＜0.01, middle dose groups
*There is significant difference P＜0.05, low dose group P＞0.05, and difference is not obvious.Point out medicine of the present invention can delay the mice physical fatigue.
Table 1 medicine is to the influence of mice swimming with a load attached to the body time
**P＜0.01
*P＜0.05
Claims (5)
1. the Chinese medicine composition with function of alleviating fatigue is characterized in that being processed by the raw material of following weight parts: Radix Morindae Officinalis 2-9 part, Radix Rhodiolae 1-6 part, Radix Panacis Quinquefolii 1-6 part.
2. according to the described Chinese medicine composition of claim 1, it is characterized in that main prescription is: 3 parts of Radix Morindae Officinaliss, 2 parts of Radix Rhodiolaes, 1 part of Radix Panacis Quinquefolii.
3. according to claim 1 or claim 2 the method for preparing of Chinese medicine composition is characterized in that mainly adopting following processing step:
A. Radix Rhodiolae was pulverized 10～60 mesh sieves; Radix Morindae Officinalis is pulverized and is not sieved, and gets Radix Morindae Officinalis and Radix Rhodiolae powder by formula proportion, and the percent by volume that dosing material amount is 6～12 times is 0%～90% ethanol water; Heating and refluxing extraction 1～3 time, each 0.5～2 hour extraction time;
B. merge extractive liquid, reclaims ethanol and concentrates, to the extractum relative density be 1.33-1.35 (50-60 ℃), obtain extract;
C. got the Radix Panacis Quinquefolii powder of 60-120 mesh sieve by formula proportion, b is extract obtained for the adding step, and mixing adds adjuvant, processes acceptable forms clinically.
4. the method for preparing of Chinese medicine composition as claimed in claim 3 is characterized in that processing tablet, capsule, granule etc.
5. according to the method for preparing of the described Chinese medicine composition of claim 3, it is characterized in that mainly adopting following processing step:
A. Radix Rhodiolae was pulverized 30 mesh sieves, and Radix Morindae Officinalis is pulverized and do not sieved, and gets Radix Morindae Officinalis and Radix Rhodiolae powder by formula proportion, and the percent by volume that dosing material amount is 8 times is 60% ethanol water, heating and refluxing extraction 3 times, and each extraction time is 1.5 hours.
B. merge extractive liquid, reclaims ethanol and concentrated, is that 1.34 (50-60 ℃) obtain extract to the extractum relative density;
C. got the Radix Panacis Quinquefolii powder of 100 mesh sieves by formula proportion, b is extract obtained for the adding step, and mixing adds adjuvant, processes tablet.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103446450A (en) * | 2012-06-01 | 2013-12-18 | 广州市奥海生物科技有限公司 | Composition capable of relieving physical fatigue and preparation method of composition |
| CN104223054A (en) * | 2013-06-24 | 2014-12-24 | 山东明仁福瑞达制药股份有限公司 | Anti-fatigue health food composition |
| CN104397700A (en) * | 2014-12-09 | 2015-03-11 | 广东省医药保健品进出口公司 | Functional health product for relieving physical fatigue and preparation method of functional health product |
| CN115671206A (en) * | 2022-11-17 | 2023-02-03 | 北京中科生物科技有限公司 | Traditional Chinese medicine peptide oral liquid for relieving fatigue and preparation method thereof |
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| CN1429622A (en) * | 2003-01-18 | 2003-07-16 | 郝基荣 | Radix rhodiolae double action lozenge |
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- 2010-10-21 CN CN2010105295010A patent/CN102451260A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1429622A (en) * | 2003-01-18 | 2003-07-16 | 郝基荣 | Radix rhodiolae double action lozenge |
Non-Patent Citations (1)
| Title |
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| 王丽英等: "七月七胶囊对负重游泳小鼠的抗疲劳作用", 《中国临床康复》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103446450A (en) * | 2012-06-01 | 2013-12-18 | 广州市奥海生物科技有限公司 | Composition capable of relieving physical fatigue and preparation method of composition |
| CN103446450B (en) * | 2012-06-01 | 2015-11-25 | 广州市奥海生物科技有限公司 | A kind of composition and method of making the same with alleviating physical fatigue function |
| CN104223054A (en) * | 2013-06-24 | 2014-12-24 | 山东明仁福瑞达制药股份有限公司 | Anti-fatigue health food composition |
| CN104397700A (en) * | 2014-12-09 | 2015-03-11 | 广东省医药保健品进出口公司 | Functional health product for relieving physical fatigue and preparation method of functional health product |
| CN115671206A (en) * | 2022-11-17 | 2023-02-03 | 北京中科生物科技有限公司 | Traditional Chinese medicine peptide oral liquid for relieving fatigue and preparation method thereof |
| CN115671206B (en) * | 2022-11-17 | 2023-07-25 | 北京中科生物科技有限公司 | Traditional Chinese medicine peptide oral liquid for relieving fatigue and preparation method thereof |
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Application publication date: 20120516 |