CN1562204A - Technique of extracting acitve ingredient from roots, stems and leaves from artichoke and application - Google Patents
Technique of extracting acitve ingredient from roots, stems and leaves from artichoke and application Download PDFInfo
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- CN1562204A CN1562204A CN 200410022218 CN200410022218A CN1562204A CN 1562204 A CN1562204 A CN 1562204A CN 200410022218 CN200410022218 CN 200410022218 CN 200410022218 A CN200410022218 A CN 200410022218A CN 1562204 A CN1562204 A CN 1562204A
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- 239000004615 ingredient Substances 0.000 title 1
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- 238000000605 extraction Methods 0.000 claims description 13
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Landscapes
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
A process for extracting the active component from the root, stem and leaf of arthicoke includes such steps as crushing, decocting in water or thermal reflux in alcohol 3 times, collected liquid, depositing, and concentrating its supernatant. It can be mixed with sweetening agent, excipient, filler and coloring agent to prepare medicines or health-care food for lossing weight, protecting liver and galladder, regulating gastrointestinal function, and relaxing cardiovascular disease.
Description
Technical field
The present invention is a kind of technology and application thereof of extracting active ingredient from artichoke roots, stem, leaf.
Background technology
Arithoke (Cynara scolymul), another name Carlina acaulis, foreign Bulbus Lilii, French Bulbus Lilii, Flos Nelumbinis Bulbus Lilii.The perennial large-scale herbaceous plant of Compositae.Marine western part in the original producton location, calendar year 2001 begins in the Yunnan successful introduction.Also there is cultivation in domestic Shandong, Shanghai, Zhejiang etc., but all fail the formation industry because of climatic effect.In Yunnan, relevant foreign trader utilizes natural, the soil of our province, and the unique advantage of weather from 2003, intends developing into the planting base of 100,000 mu of arithokes in 3～5 years.Current arithoke mainly is its bouquet outlet, and remaining a large amount of garbages: the also unmanned Application and Development of root, stem, leaf.
Arithoke is not only nutritious, rich in proteins, saccharide, vitamin and various trace elements, be a kind ofly to be subjected to the occidentals to like a kind of high-grade vegetable that eats deeply, be called as " emperor of vegetable " or " rich and powerful people's dish ", and medical value is very high, the main active ingredient that its various extracts contain is cynarin (Cynarin), chlorogenic acid (Chloro.genic.acid), flavone compound etc.Its pharmacological action has: promote biliary secretion, improve gastrointestinal function, treatment dyspepsia; Treatment constipation, diarrhoea, nauseating, vomiting; Blood fat reducing, protect cardiovascular, prevent arteriosclerosis; Liver function protecting strengthens the toxin expelling effect; Resist the infringement and the antioxidant function of free stem.These active ingredients are maximum with the rimose stem and leaf content of the pinniform of arithoke again.This shows that Development and Production arithoke rhizome leaf medicine and health food are the increase in value type engineerings of forward-looking, strategic a, growth and practicality.
Summary of the invention
The objective of the invention is to overcome the deficiency of above-mentioned prior art, a kind of technology of extracting active ingredient from artichoke roots, stem, leaf is provided, and extract is applied to medicine respectively and health food is made series of products, these series of products are to nontoxic pair of effect of human body, energy blood fat reducing, fat-reducing, hepatic cholagogic, adjusting gastrointestinal function, improve cardiovascular disease, antiobesity action is not only arranged, can also protect the liver; Its preparation technology's science, simple, convenient, fast.
Extract active ingredient technology a kind of root that the present invention proposes, stem, the leaf from arithoke, root, stem, leaf with arithoke are raw material partly, dry or dry to water content to be lower than 13%, add 5～10 times of water or ethanol after the pulverizing, decoct three times when adopting water to carry, be 1～1.5 hour at every turn; Alcohol extraction is then made the extracting solution reflux three times with the ethanol or the methanol that are not less than 50%, and each two hours, 50～70 ℃ of temperature; Merge three decocting liquids or backflow, supernatant is got in sedimentation at least 24 hours, temperature be 50～60 ℃ ,-0.07～-concentrate to such an extent that 15～20OBe water is carried paste or alcohol extraction paste under the 0.08Mpa vacuum.
Needn't dry when the root of the fresh arithoke of above-mentioned usefulness, stem, leaf are made the extraction raw material and can pulverize use.
Above-mentioned water is carried when handling, decoct with water three times to pulverizing material, amount of water is 10 times of arithoke quality for the first time, be its 7 times the second time, be its 5 times for the third time, each 1～1.5 hour, filter respectively, merge three times filtrate, sedimentation at least 24 hours, get supernatant, 50～60 ℃ ,-0.07～-concentrate under the 0.08Mpa vacuum, obtain 15～20OBe ' water and carry the paste cynara scolymus extracts, its body of paste is spray-dried, 150～180 ℃ of inlet temperatures, 80 ℃ of outlet temperatures obtain the powdered extract of arithoke.
When above-mentioned arithoke alcohol extraction is handled, add and be not less than 50% ethanol or methanol and make extracting solution, 50～70 ℃ of following reflux of temperature three times to pulverizing material, each two hours, 10 times for the first time, 7 times for the second time, 5 times for the third time, collect to merge three backflow, 50～60 ℃ ,-0.07～-concentrate under the 0.08Mpa vacuum, 15～20OBe ' alcohol extraction paste, its body of paste is spray-dried, 150～180 ℃ of inlet temperatures, 80 ℃ of outlet temperatures just obtain the powdered extract of arithoke.
The said extracted thing is pressed the manufacture method of medicine and food service industry approval, with certain proportion and corresponding auxiliary material sweeting agent, excipient, filler, coloring agent etc., the medicine and the health food of tablet, capsule, oral solutions and granule are made in combination respectively according to a conventional method, and it has blood fat reducing, loses weight, protects the liver, function of gallbladder promoting, adjusting gastrointestinal function, alleviate the effect of cardiovascular disease.
The specific embodiment:
Embodiment 1: water is proposed the preparation of paste and powdered extract
Take by weighing artichoke roots, stem, leaf raw material that 300g crushes, add entry 3000g for the first time, add water 2100g for the second time, add water 1500g for the third time, decoct each 1～1.5 hour respectively; Filter respectively then; Remerge filtrate three times, sedimentation 24 hours is got supernatant in 50～70 ℃ ,-0.07～-be concentrated into paste body shape (being equivalent to 15OBe ') under the 0.08Mpa vacuum, just obtain water and carry the paste cynara scolymus extracts.
Above-mentioned mastic is through the high speed rotating spray tower, 150～180 ℃ of inlet temperatures, and 80 ℃ of outlet temperatures, the transient heating drying obtains arithoke water and carries powder.
Embodiment 2: the aqueous and powdered extract preparation of alcohol extraction
Step is same as embodiment 1, is 50～70% ethanol or methanol with concentration, refluxes two hours at every turn, and three filtrates are in 40～70 ℃ ,-0.07～-0.08Mpa vacuum concentration to paste (is equivalent to 15～20Obe), obtains the arithoke alcohol extract; With its drying of dusting, just obtain arithoke alcohol extraction powdered extract.
Embodiment 3: the preparation of Weight-reducing and lipid-lowering dissolving liver-protecting healthy food glue
Get the paste of embodiment 1 or embodiment 2, the manufacture method by food service industry approval adds an amount of cane sugar powder, starch is made granule, drying, incapsulates racking machine, quantitatively packing, just capsule.
Get the powder of embodiment 1 or embodiment 2, in directly incapsulating, just obtain pure cynara scolymus extracts capsule.
Embodiment 4: the preparation of hepatic cholagogic sheet
Get the paste extract of embodiment 2, add an amount of Icing Sugar and dextrin, granulate by the medication preparation well-established law, drying is sifted out partly fine grained, admixes micro-Mentholum ethanol liquid, presses the well-established law tabletting behind the mixing.
Embodiment 5: improve the health food preparation of gastrointestinal function granule
Get the arithoke body of paste of embodiment 1 or embodiment 2, by the manufacture method of food service industry approval, add an amount of Icing Sugar and cyclodextrin and granulate, drying sprays into micro-fruity flavor and Mentholum alcohol liquid, mixing, and packing makes granule.
Claims (5)
1. extracting the technology of active ingredient from artichoke roots, stem, leaf, is raw material partly with root, stem, the leaf of arithoke, dries or dry to water content to be lower than 13%, adds 5～10 times of water or ethanol after the pulverizing, when carrying, water decocts three times, and be 1～1.5 hour at every turn; Alcohol extraction is then made the extracting solution reflux three times with the ethanol or the methanol that are not less than 50%, and each two hours, 50～70 ℃ of temperature; Merge three decocting liquids or backflow, supernatant is got in sedimentation at least 24 hours, temperature be 50～60 ℃ ,-0.07～-concentrate under the 0.08Mpa vacuum and obtain 15～20OBe ' water and carry paste or alcohol extraction paste.
2. technology according to claim 1 is characterized in that: needn't dry when making the extraction raw material with root, stem, the leaf of fresh arithoke, be that direct water is carried or alcohol extraction is handled after the pulverizing.
3. according to claim 1 and 2 described technologies, it is characterized in that: decoct with water three times to pulverizing material when water is carried, amount of water is pulverized 10 times that expect quality for arithoke for the first time, be its 7 times the second time, be its 5 times for the third time, each 1～1.5 hour, filter respectively then, merge three times filtrate, sedimentation at least 24 hours, get supernatant, at 50～60 ℃,-0.07～-concentrate under the 0.08Mpa vacuum, obtain 15～20OBe ' water and carry the paste cynara scolymus extracts, its body of paste is spray-dried, 150～180 ℃ of inlet temperatures, 80 ℃ of outlet temperatures obtain the powdered extract of arithoke.
4. technology according to claim 1, it is characterized in that: during alcohol extraction, add and be not less than 50% ethanol or methanol and make extracting solution to pulverizing material, 50～70 ℃ of following reflux of temperature three times, each two hours, 10 times for the first time, 7 times for the second time, 5 times for the third time, collect to merge three backflow, 50～60 ℃ ,-0.07～-concentrate under the 0.08Mpa vacuum 15～20OBe ' alcohol extraction paste, its body of paste is spray-dried, 150～180 ℃ of inlet temperatures, 80 ℃ of outlet temperatures just obtain the powdered extract of arithoke.
5. extract the application of active ingredient according to claim 1 in artichoke roots, stem, the leaf, it is characterized in that: the said extracted thing is pressed the manufacture method of medicine and food service industry approval, with a certain proportion of sweeting agent, excipient, adjuvant such as filler, coloring agent makes up medicine and the health food of making tablet, capsule, oral solutions and granule according to a conventional method respectively.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2004100222183A CN100496525C (en) | 2004-04-02 | 2004-04-02 | Technique of extracting acitve ingredient from roots, stems and leaves from artichoke and application |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2004100222183A CN100496525C (en) | 2004-04-02 | 2004-04-02 | Technique of extracting acitve ingredient from roots, stems and leaves from artichoke and application |
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| CN1562204A true CN1562204A (en) | 2005-01-12 |
| CN100496525C CN100496525C (en) | 2009-06-10 |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101560155B (en) * | 2009-05-13 | 2012-02-08 | 深圳劲创生物技术有限公司 | Method for purifying cynarin in artichoke |
| CN103504252A (en) * | 2013-10-04 | 2014-01-15 | 陶峰 | Processing method for purple sweet potato salad |
| CN103874498A (en) * | 2011-09-16 | 2014-06-18 | 因德纳有限公司 | Cynara scolymus extracts for the treatment of dyslipidaemia |
| CN104256809A (en) * | 2014-09-02 | 2015-01-07 | 汇美农业科技有限公司 | Method for preparing beverage by using globe artichoke stem and leaf extracts |
| CN105012259A (en) * | 2015-08-06 | 2015-11-04 | 华侨大学 | Artichoke extract dispersible tablets and preparing method thereof |
| CN105410922A (en) * | 2015-12-22 | 2016-03-23 | 湖南文理学院 | Globe artichoke cake and preparation method thereof |
| CN105477037A (en) * | 2015-11-19 | 2016-04-13 | 汇美农业科技有限公司 | Preparation process and content detection method of artichoke extract |
| CN106562377A (en) * | 2016-10-31 | 2017-04-19 | 汇美农业科技有限公司 | Preparation method of globe artichoke sweetness inductive agent |
| CN107307134A (en) * | 2016-10-17 | 2017-11-03 | 云南农业大学 | A kind of arithoke teabag drink and preparation method thereof |
| CN108142881A (en) * | 2018-03-20 | 2018-06-12 | 爱可道生物科技有限公司 | A kind of arithoke alabastrum extract blood pressure lowering capsule product and its production technology |
| CN108774131A (en) * | 2018-04-23 | 2018-11-09 | 华侨大学 | A kind of method that Simulated Moving Bed Chromatography method isolates and purifies cynarin and chlorogenic acid in globe artichoke |
| CN109453129A (en) * | 2018-12-21 | 2019-03-12 | 张建荣 | A kind of arithoke essence piece and preparation method thereof |
| CN110897952A (en) * | 2019-12-03 | 2020-03-24 | 朱建康 | Preparation method and application of artichoke root extract |
| CN111166704A (en) * | 2019-12-10 | 2020-05-19 | 沈海强 | Infant bath lotion with skin improving effect |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0625155T3 (en) * | 1992-01-27 | 2001-11-12 | Janssen Pharmaceutica Nv | Pyrroloimidazolyl- and imidazopyridinyl-substituted 1H-benzimidazole derivatives as aromatase inhibitors |
| CN1226945C (en) * | 2003-07-23 | 2005-11-16 | 昆明英之源农业科技开发有限公司 | Procedure for preparing pickled artichoke |
-
2004
- 2004-04-02 CN CNB2004100222183A patent/CN100496525C/en not_active Expired - Fee Related
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101560155B (en) * | 2009-05-13 | 2012-02-08 | 深圳劲创生物技术有限公司 | Method for purifying cynarin in artichoke |
| CN103874498A (en) * | 2011-09-16 | 2014-06-18 | 因德纳有限公司 | Cynara scolymus extracts for the treatment of dyslipidaemia |
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| CN108774131B (en) * | 2018-04-23 | 2021-04-30 | 华侨大学 | Method for separating and purifying cynarin and chlorogenic acid in artichoke by simulated moving bed chromatography |
| CN109453129A (en) * | 2018-12-21 | 2019-03-12 | 张建荣 | A kind of arithoke essence piece and preparation method thereof |
| CN110897952A (en) * | 2019-12-03 | 2020-03-24 | 朱建康 | Preparation method and application of artichoke root extract |
| CN111166704A (en) * | 2019-12-10 | 2020-05-19 | 沈海强 | Infant bath lotion with skin improving effect |
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