CN108851054A - A kind of eucommia Bark male flower chewable tablets and preparation method thereof - Google Patents
A kind of eucommia Bark male flower chewable tablets and preparation method thereof Download PDFInfo
- Publication number
- CN108851054A CN108851054A CN201810729997.2A CN201810729997A CN108851054A CN 108851054 A CN108851054 A CN 108851054A CN 201810729997 A CN201810729997 A CN 201810729997A CN 108851054 A CN108851054 A CN 108851054A
- Authority
- CN
- China
- Prior art keywords
- powder
- eucommia bark
- male flower
- bark male
- ultramicro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000208688 Eucommia Species 0.000 title claims abstract description 117
- 239000007910 chewable tablet Substances 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 239000000843 powder Substances 0.000 claims abstract description 130
- 241001506047 Tremella Species 0.000 claims abstract description 46
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 39
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 39
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 39
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 39
- 239000002994 raw material Substances 0.000 claims abstract description 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 26
- 239000011122 softwood Substances 0.000 claims description 22
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 14
- 230000001954 sterilising effect Effects 0.000 claims description 14
- 239000006228 supernatant Substances 0.000 claims description 14
- 235000019441 ethanol Nutrition 0.000 claims description 13
- 229910052757 nitrogen Inorganic materials 0.000 claims description 13
- 238000004806 packaging method and process Methods 0.000 claims description 8
- 241000196324 Embryophyta Species 0.000 claims description 7
- 239000012153 distilled water Substances 0.000 claims description 7
- 238000007731 hot pressing Methods 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- 238000004321 preservation Methods 0.000 claims description 7
- 238000000498 ball milling Methods 0.000 claims description 6
- 230000002457 bidirectional effect Effects 0.000 claims description 6
- 238000004140 cleaning Methods 0.000 claims description 6
- 239000008367 deionised water Substances 0.000 claims description 6
- 229910021641 deionized water Inorganic materials 0.000 claims description 6
- 238000007710 freezing Methods 0.000 claims description 6
- 230000008014 freezing Effects 0.000 claims description 6
- 238000000227 grinding Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 238000007873 sieving Methods 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 6
- 102000004169 proteins and genes Human genes 0.000 abstract description 6
- 108090000623 proteins and genes Proteins 0.000 abstract description 6
- 210000004185 liver Anatomy 0.000 abstract description 5
- 150000004676 glycans Chemical class 0.000 abstract description 3
- 210000003734 kidney Anatomy 0.000 abstract description 3
- 229920001282 polysaccharide Polymers 0.000 abstract description 3
- 239000005017 polysaccharide Substances 0.000 abstract description 3
- 230000036039 immunity Effects 0.000 abstract description 2
- 235000015097 nutrients Nutrition 0.000 abstract description 2
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 201000001421 hyperglycemia Diseases 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 102100020720 Calcium channel flower homolog Human genes 0.000 description 104
- 101000932468 Homo sapiens Calcium channel flower homolog Proteins 0.000 description 104
- 229930003944 flavone Natural products 0.000 description 11
- 235000011949 flavones Nutrition 0.000 description 11
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 8
- 150000002212 flavone derivatives Chemical class 0.000 description 8
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 8
- 238000005119 centrifugation Methods 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 235000016709 nutrition Nutrition 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 235000018102 proteins Nutrition 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 230000000975 bioactive effect Effects 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 150000002213 flavones Chemical class 0.000 description 3
- 229930003935 flavonoid Natural products 0.000 description 3
- 150000002215 flavonoids Chemical class 0.000 description 3
- 235000017173 flavonoids Nutrition 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- 239000001814 pectin Substances 0.000 description 3
- 235000010987 pectin Nutrition 0.000 description 3
- 229920001277 pectin Polymers 0.000 description 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- 241001248610 Ophiocordyceps sinensis Species 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 244000237330 gutta percha tree Species 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 1
- 206010000234 Abortion spontaneous Diseases 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 241000512259 Ascophyllum nodosum Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000208686 Eucommiaceae Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 239000000899 Gutta-Percha Substances 0.000 description 1
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- 208000002682 Hyperkalemia Diseases 0.000 description 1
- 206010021036 Hyponatraemia Diseases 0.000 description 1
- 229920002752 Konjac Polymers 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 244000241838 Lycium barbarum Species 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 235000015468 Lycium chinense Nutrition 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 240000000342 Palaquium gutta Species 0.000 description 1
- -1 Phenylpropanoid Glycosides Chemical class 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002929 anti-fatigue Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003262 anti-osteoporosis Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 239000008845 cholagoga Substances 0.000 description 1
- 229940124571 cholagogue Drugs 0.000 description 1
- 229920003211 cis-1,4-polyisoprene Polymers 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000006837 decompression Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000010159 dioecy Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 235000021433 fructose syrup Nutrition 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 229920000588 gutta-percha Polymers 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000001497 healthy food Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 150000002515 isoflavone derivatives Chemical class 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- 239000000905 isomalt Substances 0.000 description 1
- 235000010439 isomalt Nutrition 0.000 description 1
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 1
- 229910052640 jadeite Inorganic materials 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 235000004213 low-fat Nutrition 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000002366 mineral element Substances 0.000 description 1
- 208000015994 miscarriage Diseases 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229930015704 phenylpropanoid Natural products 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 235000019624 protein content Nutrition 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 229930000044 secondary metabolite Natural products 0.000 description 1
- 235000015170 shellfish Nutrition 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 208000000995 spontaneous abortion Diseases 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Anesthesiology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Physiology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of eucommia Bark male flower chewable tablets and preparation method thereof, which is made of eucommia Bark male flower powder concentrated extracting solution, broken wall eucommia Bark male flower powder, Chinese yam Ultramicro-powder and tremella Ultramicro-powder direct tablet compressing.Eucommia Bark male flower chewable tablets produced by the present invention does not add any conventional excipients, it is raw material using eucommia Bark male flower extracting solution, Chinese yam provides stickiness with tremella polysaccharide abundant for chewable tablets, simultaneously rich in polysaccharide abundant, protein etc., long-term use can effectively improve immunity, strong liver, kidney tonifying, defaecation, sleeping, lower hyperlipidemia, hypertension, hyperglycemia of human body etc., and preparation process is simple, it is at low cost, the nutrient laden demand of crowd can effectively be met, high-volume industrial production is realized, have a extensive future.
Description
Technical field
The present invention relates to chewable tablets processing technique fields, and in particular to a kind of eucommia Bark male flower chewable tablets and preparation method thereof.
Background technique
Cortex Eucommiae（Eucommia ulmoides Oliv.）It is the distinctive name of China for the deciduous tree that Eucommiaceae Cortex Eucommiae belongs to
Precious medicinal material tree species, and the most wide important glue source plant of adaptation range in the world belong to Chinese Second Class Key Protected Plant, are in geologic history
The raw few survivors tree species of the Gu that quaternary glacier motion residual is got off.Before more than 2000 years, Cortex Eucommiae is by China as in important
Medicinal material, income《Sheng Nong's herbal classic》.Started since 1980, domestic and international numerous studies discovery Cortex Eucommiae whole body has highly important
Value, eucommia bark, leaf, gutta percha contained by fruit are the most important rubber sources in addition to Hevea rubber, not only
It can be used as drug, and be also used as health care product, functional food and feed addictive, there is nourishing liver and kidney, strengthening the bones and muscles, drop
The effects of blood pressure, reducing blood lipid, antifatigue, anti-osteoporosis, anti-cell toxicity and protection liver.Cortex Eucommiae has wide application
Prospect, the exploitation of new product seem more and more necessary.
Cortex Eucommiae stamen is sprouted prior to young leaves shoot, and the contradiction nutritionally with leaf and New shoot growth is avoided, and has been obtained complete
The energy supply in portion, just because of this, the nutriment of eucommia pollen are abundant and comprehensive.Ma Renping etc. passes through measurement discovery, Cortex Eucommiae
Pollen has the characteristics that high protein and low fat, protein content（28.27%）Higher than the average content of 40 kinds of common pollen
（20.08%）, fat content subaverage；The essential amino acids content of needed by human body is 6.097 %, it is necessary to amino acid ratio
It is better than the mode standard value of FAO/WHO recommendation；The characteristics of hyperkalemia hyponatremia is presented in eucommia pollen Mineral Elements in Jadeite Shellfish, this illustrates to shut out
Secondary pollen can be to supplement potassium element；General flavone content is higher (3.29g/100g) in secondary metabolite in eucommia pollen,
By the way that 29 kinds of common pollen flavones content measurement discoveries, eucommia pollen flavones content exceeds 1.4 times of its average value.It grinds above
Study carefully and shows eucommia pollen research and development value with higher.
Eucommia Bark male flower is one of the main portions of Cortex Eucommiae effective component, and dioecism has anthocaulus and without perianth category unisexual flower.
Eucommia Bark male flower is in addition to containing multiple efficacies ingredients such as lignanoids, Phenylpropanoid Glycosides class, flavonoids, polysaccharide, iridoids, also
Contain a variety of amino acid such as serine, glutamic acid, glycine, alanine, arginine and the necessary microelement of a variety of human bodies
And minerals.With decompression, anti-inflammatory, antiviral, enhancing is immune, cholagogue, liver protection diuresis, anti-oxidant, antitumor, miscarriage prevention, anti-bone
The health-care efficacies such as matter osteoporosis.
Currently, the exploitation of eucommia Bark male flower focuses primarily upon production eucommia ulmoides male flower tea or beverage, have certain reducing blood lipid,
Blood pressure lowering, enhancing human immunity and other effects, but since the eucommia Bark male flower annual florescence only has one week or so, be not easy to protect after picking
It deposits, and the eucommia Bark male flower tea-drinking after brewing is easy to be lost nutritional ingredient therein, and utilization rate of active components is caused to decline.At present will
The invention that eucommia Bark male flower is used to prepare chewable tablets rarely has, a kind of eucommia Bark male flower pressed candy disclosed in CN201610456281.0 and
Its production technology is by eucommia Bark male flower, wolfberry fruit powder, fructus alpiniae oxyphyllae, Chinese yam, hydroxypropyl methyl cellulose, isomalt, tristearin
Sour magnesium pre-processed, weighed, being mixed, being pelletized, being dried, tabletting, packaging branch are made, which is utilized between various raw materials
Biological action cooperative compensating, but the extraction of effective active matter in eucommia Bark male flower pollen is had ignored, bioavailability is not
It is high.A kind of eucommia Bark male flower cordyceps sinensis soybean germ isoflavones chewable tablets disclosed in CN201611138215.5 and preparation method thereof, will
It is soybean germ, Chinese yam, eucommia Bark male flower, cordyceps sinensis, fructus alpiniae oxyphyllae, fructus lycii, rhizoma polygonati, glucose, sucrose, citric acid, lactose, sweet
Reveal alcohol, magnesium stearate, lactic acid bacteria, kelp residue, sodium bicarbonate, Radix Phodiolae Polyose, starch according to conventional chewable tablets processing method system
It is standby to form, have ignored the extraction of eucommia Bark male flower active material.
Based on above-mentioned analysis, a kind of bioactive substance is high, replaces conventional excipients using polysaccharose substance, is rich in simultaneously
Pectin abundant, protein etc. effectively meet more nutrition, eucommia Bark male flower chewable tablets easy to carry is badly in need of in current industry
's.
Summary of the invention
In view of above-mentioned deficiency, taken the purpose of the present invention is to provide a kind of bioactive substance height, using polysaccharose substance
For conventional excipients, simultaneously rich in pectin abundant, protein etc., effectively meet more nutrition, eucommia Bark male flower nozzle easy to carry
Chew piece.
It carries out largely groping what summary obtained by inventor, Du that dosage of each component is prepared within the following weight ranges
Zhong Xionghua chewable tablets has bioactive substance is high, is rich in pectin abundant, protein etc., effectively meets more nutrition, carrying side
Just characteristic.The eucommia Bark male flower chewable tablets is made by the following method：
A kind of preparation method of eucommia Bark male flower chewable tablets, includes the following steps：
（1）Make softwood：It takes in broken wall eucommia Bark male flower powder, Chinese yam Ultramicro-powder and tremella Ultramicro-powder investment mixing machine and mixes, then
It is slowly added to eucommia Bark male flower powder concentrated extracting solution and softwood is made；
（2）It is granulated and dry：Softwood is spray-dried, particle crosses 20 meshes, stands 20min；
（3）Tabletting, sterilizing, packaging：Tabletting is carried out under 10 ~ 15MPa, then sterilize under ultraviolet light 20 ~ 30min, after sterilizing
By nitrogen charging single dose blister formula hot pressing envelope in a manner of or the bottled mode sealed package of multi-dose, preservation under room temperature.
Further, the eucommia Bark male flower Ultramicro-powder is prepared by the following method：By the removal of impurities of eucommia Bark male flower fresh flower powder, clearly
After washing, drying, 3 ~ 5min of liquid nitrogen frozen is placed in ball milling instrument and carries out grinding 1 ~ 3min of broken wall, obtains broken wall eucommia Bark male flower powder.
Further, the Chinese yam Ultramicro-powder is prepared by the following method：After taking fresh Chinese yam to clean peeling, second is used
Alcohol is cleaned 1 time, is then cleaned 2 times with deionized water, is dried to moisture content < 8% with 60~70 DEG C, then carried out slightly with pulverizer
It crushes, obtains 20 ~ 30 mesh coarse powder, then place it in rod mill and crush, then cross 300 meshes through bidirectional airflow sieving machine, obtain mountain
Medicine Ultramicro-powder.
Further, the tremella Ultramicro-powder is prepared by the following method：After taking fresh tremella to clean, it is put into freezing dress
Freezing is set, then at -15 DEG C, merging pulverizer coarse crushing places into micronizer at frost tremella coarse powder, 300 meshes are crossed,
Obtain tremella Ultramicro-powder.
Further, the eucommia Bark male flower powder concentrated extracting solution is prepared by the following method：Eucommia Bark male flower fresh flower powder removes
It is miscellaneous, clean, dry after distilled water is added, and extract 4h under low temperature, then centrifugation is extracted, and collects supernatant, repeats to extract three
It is secondary, merge supernatant.
Further, the tremella freezing is to freeze 12 hours at -30 DEG C.
Further, the chewable tablets is made of the raw material of following weight：40 ~ 60 parts of broken wall eucommia Bark male flower powder,
5 ~ 10 parts of Chinese yam Ultramicro-powder, 5 ~ 10 parts of tremella Ultramicro-powder, 30 ~ 40 parts of eucommia Bark male flower powder concentrated extracting solution.
Further, the chewable tablets is made of the raw material of following weight：50 parts of broken wall eucommia Bark male flower powder, Chinese yam
7.5 parts of Ultramicro-powder, 7.5 parts of tremella Ultramicro-powder, 35 parts of eucommia Bark male flower powder concentrated extracting solution.
The beneficial effects of the present invention are：
1, the present invention directly eucommia Bark male flower is ground at low temperature, avoid high temperature drying initiation eucommia Bark male flower activity at
Divide loss, the broken wall eucommia Bark male flower powder for being sufficiently reserved bioactivity has been obtained, through broken wall eucommia Bark male flower made from the method for the present invention
Powder organic solvent-free remains, is pollution-free, and bioactive ingredients and nutrient composition content are all significantly higher than conventional side in eucommia Bark male flower
Broken wall eucommia Bark male flower powder made from method, farthest remains the active constituent of eucommia Bark male flower.
2, the present invention use eucommia Bark male flower water extract, broken wall eucommia Bark male flower powder to surpass, Chinese yam Ultramicro-powder and tremella Ultramicro-powder for
In entire production process and conventional excipients are not used and alcohol makes softwood in raw material, but good with tremella by Chinese yam
Viscosity auxiliary chewing sheetmolding, reduces influence of the alcohol to nutritional ingredient in eucommia Bark male flower, Chinese yam and tremella.
3, thick protein, crude fibre and a variety of amino acid rich in Chinese yam and tremella used in the present invention, make
Eucommia Bark male flower chewable tablets not only has a good strong liver, kidney tonifying effect, while can also sleeping, defaecation, while by Chinese yam with
In tremella.
4, the present invention retains preferably the neutraceutical active ingredients of various raw materials, caters to consumer couple without extreme processing conditions
The demand of healthy food, and manufacture craft is simple, it is at low cost, it is suitable for industrialized production.
Specific embodiment
Embodiment 1
A kind of eucommia Bark male flower chewable tablets
（1）Prepare eucommia Bark male flower Ultramicro-powder：After cleaning by eucommia Bark male flower fresh flower powder, clean, dry, liquid nitrogen frozen 4min, juxtaposition
Grinding broken wall 2min is carried out in ball milling instrument, obtains broken wall eucommia Bark male flower powder；
（2）Prepare Chinese yam Ultramicro-powder：After taking fresh Chinese yam to clean peeling, is cleaned 1 time using ethyl alcohol, then cleaned with deionized water
2 times, it is dried to moisture content < 8% with 65 DEG C, then carry out coarse crushing with pulverizer, obtains 25 mesh coarse powder, then place it in rod mill
Then interior crushing crosses 300 meshes through bidirectional airflow sieving machine, obtain Chinese yam Ultramicro-powder；
（3）Prepare tremella Ultramicro-powder：After taking fresh tremella to clean, it is put into refrigerating plant, freezes 12 hours at -30 DEG C, then
At -15 DEG C, merging pulverizer coarse crushing places into micronizer at frost tremella coarse powder, crosses 300 meshes, obtains tremella ultra micro
Powder；
（4）Prepare eucommia Bark male flower powder concentrated extracting solution：Eucommia Bark male flower fresh flower powder cleans, cleans, dry after be added distilled water, and in
4h is extracted under low temperature, then centrifugation is extracted, and collects supernatant, is repeated to extract three times, is merged supernatant；
（5）Make softwood：It takes broken wall eucommia Bark male flower powder 50kg, Chinese yam Ultramicro-powder 7.5kg to put into tremella Ultramicro-powder 7.5kg to mix
It is mixed in machine, is then slowly added to eucommia Bark male flower powder concentrated extracting solution 35kg and is made softwood, hardness is pinched agglomerating with hand, and light pressure dissipates
Subject to；
（6）It is granulated and dry：Softwood is spray-dried, particle crosses 20 meshes, stands 20min；
（7）Tabletting, sterilizing, packaging：Tabletting is carried out under 12.5MPa, then under ultraviolet light sterilize 20 ~ 30min, after sterilizing with
Mode or the bottled mode sealed package of multi-dose, preservation under room temperature are sealed in nitrogen charging single dose blister formula hot pressing.
Embodiment 2
A kind of eucommia Bark male flower chewable tablets
（1）Prepare eucommia Bark male flower Ultramicro-powder：After cleaning by eucommia Bark male flower fresh flower powder, clean, dry, liquid nitrogen frozen 3min, juxtaposition
Grinding broken wall 3min is carried out in ball milling instrument, obtains broken wall eucommia Bark male flower powder；
（2）Prepare Chinese yam Ultramicro-powder：After taking fresh Chinese yam to clean peeling, is cleaned 1 time using ethyl alcohol, then cleaned with deionized water
2 times, it is dried to moisture content < 8% with 60 DEG C, then carry out coarse crushing with pulverizer, obtains 20 mesh coarse powder, then place it in rod mill
Then interior crushing crosses 300 meshes through bidirectional airflow sieving machine, obtain Chinese yam Ultramicro-powder；
（3）Prepare tremella Ultramicro-powder：After taking fresh tremella to clean, it is put into refrigerating plant, freezes 12 hours at -30 DEG C, then
At -15 DEG C, merging pulverizer coarse crushing places into micronizer at frost tremella coarse powder, crosses 300 meshes, obtains tremella ultra micro
Powder；
（4）Prepare eucommia Bark male flower powder concentrated extracting solution：Eucommia Bark male flower fresh flower powder cleans, cleans, dry after be added distilled water, and in
4h is extracted under low temperature, then centrifugation is extracted, and collects supernatant, is repeated to extract three times, is merged supernatant；
（5）Make softwood：Broken wall eucommia Bark male flower powder 40kg, Chinese yam Ultramicro-powder 10kg and tremella Ultramicro-powder 10kg is taken to put into mixing machine
Middle mixing is then slowly added to eucommia Bark male flower powder concentrated extracting solution 30kg and is made softwood, and hardness is pinched agglomerating with hand, and light pressure, which dissipates, is
It is quasi-；
（6）It is granulated and dry：Softwood is spray-dried, particle crosses 20 meshes, stands 20min；
（7）Tabletting, sterilizing, packaging：Tabletting is carried out under 10MPa, then sterilize under ultraviolet light 30min, with nitrogen charging after sterilizing
Mode or the bottled mode sealed package of multi-dose, preservation under room temperature are sealed in single dose blister formula hot pressing.
Embodiment 3
A kind of eucommia Bark male flower chewable tablets
（1）Prepare eucommia Bark male flower Ultramicro-powder：After cleaning by eucommia Bark male flower fresh flower powder, clean, dry, liquid nitrogen frozen 5min, juxtaposition
Grinding broken wall 1min is carried out in ball milling instrument, obtains broken wall eucommia Bark male flower powder；
（2）Prepare Chinese yam Ultramicro-powder：After taking fresh Chinese yam to clean peeling, is cleaned 1 time using ethyl alcohol, then cleaned with deionized water
2 times, it is dried to moisture content < 8% with 70 DEG C, then carry out coarse crushing with pulverizer, obtains 30 mesh coarse powder, then place it in rod mill
Then interior crushing crosses 300 meshes through bidirectional airflow sieving machine, obtain Chinese yam Ultramicro-powder；
（3）Prepare tremella Ultramicro-powder：After taking fresh tremella to clean, it is put into refrigerating plant, freezes 12 hours at -30 DEG C, then
At -15 DEG C, merging pulverizer coarse crushing places into micronizer at frost tremella coarse powder, crosses 300 meshes, obtains tremella ultra micro
Powder；
（4）Prepare eucommia Bark male flower powder concentrated extracting solution：Eucommia Bark male flower fresh flower powder cleans, cleans, dry after be added distilled water, and in
4h is extracted under low temperature, then centrifugation is extracted, and collects supernatant, is repeated to extract three times, is merged supernatant；
（5）Make softwood：Broken wall eucommia Bark male flower powder 60kg, Chinese yam Ultramicro-powder 5kg and tremella Ultramicro-powder 5kg is taken to put into mixing machine
It mixes, is then slowly added to eucommia Bark male flower powder concentrated extracting solution 40kg and is made softwood, hardness is pinched agglomerating with hand, and light pressure, which dissipates, is
It is quasi-；
（6）It is granulated and dry：Softwood is spray-dried, particle crosses 20 meshes, stands 20min；
（7）Tabletting, sterilizing, packaging：Tabletting is carried out under 15MPa, then sterilize under ultraviolet light 20min, with nitrogen charging after sterilizing
Mode or the bottled mode sealed package of multi-dose, preservation under room temperature are sealed in single dose blister formula hot pressing.
Comparative example 1
A kind of eucommia Bark male flower chewable tablets
（Raw material proportioning is with embodiment 1, using room temperature broken wall treatment when only preparing eucommia Bark male flower Ultramicro-powder.）
（1）Prepare eucommia Bark male flower Ultramicro-powder：After cleaning by eucommia Bark male flower fresh flower powder, clean, dry, it is placed in broken wall in wall-breaking machine
2min obtains broken wall eucommia Bark male flower powder；
（2）Prepare Chinese yam Ultramicro-powder：After taking fresh Chinese yam to clean peeling, is cleaned 1 time using ethyl alcohol, then cleaned with deionized water
2 times, it is dried to moisture content < 8% with 65 DEG C, then carry out coarse crushing with pulverizer, obtains 25 mesh coarse powder, then place it in rod mill
Then interior crushing crosses 300 meshes through bidirectional airflow sieving machine, obtain Chinese yam Ultramicro-powder；
（3）Prepare tremella Ultramicro-powder：After taking fresh tremella to clean, it is put into refrigerating plant, freezes 12 hours at -30 DEG C, then
At -15 DEG C, merging pulverizer coarse crushing places into micronizer at frost tremella coarse powder, crosses 300 meshes, obtains tremella ultra micro
Powder；
（4）Prepare eucommia Bark male flower powder concentrated extracting solution：Eucommia Bark male flower fresh flower powder cleans, cleans, dry after be added distilled water, and in
4h is extracted under low temperature, then centrifugation is extracted, and collects supernatant, is repeated to extract three times, is merged supernatant；
（5）Make softwood：It takes broken wall eucommia Bark male flower powder 50kg, Chinese yam Ultramicro-powder 7.5kg to put into tremella Ultramicro-powder 7.5kg to mix
It is mixed in machine, is then slowly added to eucommia Bark male flower powder concentrated extracting solution 35kg and is made softwood, hardness is pinched agglomerating with hand, and light pressure dissipates
Subject to；
（6）It is granulated and dry：Softwood is spray-dried, particle crosses 20 meshes, stands 20min；
（7）Tabletting, sterilizing, packaging：Tabletting is carried out under 12.5MPa, then under ultraviolet light sterilize 20 ~ 30min, after sterilizing with
Mode or the bottled mode sealed package of multi-dose, preservation under room temperature are sealed in nitrogen charging single dose blister formula hot pressing.
Comparative example 2
A kind of eucommia Bark male flower chewable tablets
（Embodiment only replaces Chinese yam Ultramicro-powder and tremella ultra micro in raw material ratio with embodiment 1 with conventional excipients
Powder）
（1）Prepare eucommia Bark male flower Ultramicro-powder：After cleaning by eucommia Bark male flower fresh flower powder, clean, dry, liquid nitrogen frozen 4min, juxtaposition
Grinding broken wall 2min is carried out in ball milling instrument, obtains broken wall eucommia Bark male flower powder；
（2）Prepare eucommia Bark male flower powder concentrated extracting solution：Eucommia Bark male flower fresh flower powder cleans, cleans, dry after be added distilled water, and in
4h is extracted under low temperature, then centrifugation is extracted, and collects supernatant, is repeated to extract three times, is merged supernatant；
（3）Make softwood：Broken wall eucommia Bark male flower powder 50kg is taken, auxiliary material konjaku flour 28kg, synanthrin 25kg, fructose syrup is added
35kg, citric acid 2kg, sodium carboxymethylcellulose 7.5kg put into mixing machine and are uniformly mixed, be then slowly added to eucommia Bark male flower
Powder concentrated extracting solution 35kg is made softwood, hardness pinched with hand it is agglomerating, subject to light pressure dissipates；
（4）It is granulated and dry：Softwood is spray-dried, particle crosses 20 meshes, stands 20min；
（5）Tabletting, sterilizing, packaging：Tabletting is carried out under 12.5MPa, then under ultraviolet light sterilize 20 ~ 30min, after sterilizing with
Mode or the bottled mode sealed package of multi-dose, preservation under room temperature are sealed in nitrogen charging single dose blister formula hot pressing.
Test example 1
The extraction of general flavone in each group embodiment and comparative example
Sample 1.0000g is accurately weighed, is set in a round bottom flask, by solid-liquid ratio 1:60% ethyl alcohol is added, in ultrasound in 30 (g/mL)
Ultrasonic wave assists alcohol extracting under the conditions of temperature 60cc, ultrasonic time 30min, ultrasonic power 150W.Ethanol solution constant volume after suction filtration.It is quasi-
Extracting solution 5.0mL is really measured, is placed in 50mL volumetric flask.Absorbance is measured at 510nm by standard curve, is calculated in extracting solution
The content and recovery rate of general flavone, concrete outcome is as shown in table 1.
General flavone recovery rate=[(eucommia Bark male flower general flavone content × pipette volume × extension rate/eucommia Bark male flower sample matter
Amount)] × 100%
Test example 2
The antioxidant activity research of general flavone uses Phen-Fe in each group embodiment and comparative example2+Oxidizing process evaluation is total yellow
Ketone removes ultra-oxygen anion free radical ability, and calculation formula is as follows：
O2-Clearance rate (%)={ [ABlank-(ASample-A0)]/ABlank}×100
The active component detection result of 1 each group flavones of table
。
As known from Table 1, embodiment 1 ~ 3 by eucommia Bark male flower after low temperature broken wall treatment, the super-micro wall-broken Cortex Eucommiae that is prepared
Extracting flavonoids rate, general flavone concentration contained in male pollen are obviously higher than comparative example 1 and comparative example 2, it can be seen that pass through
Directly eucommia Bark male flower is ground under low temperature, the eucommia Bark male flower active ingredient loss of high temperature drying initiation is avoided, obtains
The higher broken wall eucommia Bark male flower powder of flavonoid concentration, and combine after eucommia Bark male flower water extract is used in conjunction with, improve eucommia Bark male flower
Utilization rate reduces waste.Traditional excipient is substituted with Chinese yam Ultramicro-powder and tremella Ultramicro-powder, wine is not used in preparation process
Soft ability is made in purification, reduces influence of the alcohol to nutritional ingredient in eucommia Bark male flower, Chinese yam and tremella, remains chewable tablets general flavone
Antioxidant activity.
The foregoing is merely highly preferred embodiment of the present invention, all impartial changes done according to scope of the present invention patent
Change and modify, belongs to the range that the present invention is covered.
Claims (9)
1. a kind of preparation method of eucommia Bark male flower chewable tablets, which is characterized in that the preparation method includes the following steps：
Make softwood：It takes in broken wall eucommia Bark male flower powder, Chinese yam Ultramicro-powder and tremella Ultramicro-powder investment mixing machine and mixes, then slowly
Eucommia Bark male flower powder concentrated extracting solution is added, softwood is made；
It is granulated and dry：Softwood is spray-dried, particle crosses 20 meshes, stands 20min；
Tabletting, sterilizing, packaging：Tabletting is carried out under 10 ~ 15MPa, then sterilize under ultraviolet light 20 ~ 30min, to fill after sterilizing
Mode or the bottled mode sealed package of multi-dose, preservation under room temperature are sealed in nitrogen single dose blister formula hot pressing.
2. preparation method according to claim 1, which is characterized in that the eucommia Bark male flower Ultramicro-powder is prepared by the following method
It forms：After cleaning by eucommia Bark male flower fresh flower powder, clean, dry, 3 ~ 5min of liquid nitrogen frozen is placed in ball milling instrument and carries out grinding broken wall
1 ~ 3min obtains broken wall eucommia Bark male flower powder.
3. preparation method according to claim 1, which is characterized in that the Chinese yam Ultramicro-powder prepare by the following method and
At：It after taking fresh Chinese yam to clean peeling, is cleaned 1 time using ethyl alcohol, is then cleaned 2 times with deionized water, dried with 60~70 DEG C
Coarse crushing is carried out to moisture content < 8%, then with pulverizer, obtains 20 ~ 30 mesh coarse powder, then places it in rod mill and crushes, then
300 meshes are crossed through bidirectional airflow sieving machine, obtain Chinese yam Ultramicro-powder.
4. preparation method according to claim 1, which is characterized in that the tremella Ultramicro-powder prepare by the following method and
At：After taking fresh tremella to clean, it is put into refrigerating plant freezing, then at -15 DEG C, merging pulverizer coarse crushing is thick at frost tremella
Powder places into micronizer, crosses 300 meshes, obtains tremella Ultramicro-powder.
5. preparation method according to claim 1, which is characterized in that the eucommia Bark male flower powder concentrated extracting solution is by such as lower section
Method is prepared：Eucommia Bark male flower fresh flower powder cleans, cleans, dry after distilled water is added, and extract 4h under low temperature, be then centrifuged
It extracts, collects supernatant, repeat to extract three times, merge supernatant.
6. the preparation method according to claim 4, which is characterized in that the tremella freezing is at -30 DEG C, and freezing 12 is small
When.
7. eucommia Bark male flower chewable tablets made from a kind of preparation method any according to claim 1 ~ 6.
8. eucommia Bark male flower chewable tablets according to claim 7, which is characterized in that the chewable tablets is by following weight
Raw material be made：40 ~ 60 parts of broken wall eucommia Bark male flower powder, 5 ~ 10 parts of Chinese yam Ultramicro-powder, 5 ~ 10 parts of tremella Ultramicro-powder, eucommia Bark male flower powder
30 ~ 40 parts of concentrated extracting solution.
9. eucommia Bark male flower chewable tablets according to claim 8, which is characterized in that the chewable tablets is by following weight
Raw material be made：50 parts of broken wall eucommia Bark male flower powder, 7.5 parts of Chinese yam Ultramicro-powder, 7.5 parts of tremella Ultramicro-powder, the concentration of eucommia Bark male flower powder
35 parts of extracting solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810729997.2A CN108851054A (en) | 2018-07-05 | 2018-07-05 | A kind of eucommia Bark male flower chewable tablets and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810729997.2A CN108851054A (en) | 2018-07-05 | 2018-07-05 | A kind of eucommia Bark male flower chewable tablets and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108851054A true CN108851054A (en) | 2018-11-23 |
Family
ID=64299062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810729997.2A Pending CN108851054A (en) | 2018-07-05 | 2018-07-05 | A kind of eucommia Bark male flower chewable tablets and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108851054A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112568397A (en) * | 2020-12-04 | 2021-03-30 | 浙江蓝美生物技术有限公司 | Blueberry powder compound solid preparation capable of improving sleep and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101564124A (en) * | 2009-05-27 | 2009-10-28 | 云南省林业科学院 | Pelletizing method of pine pollen |
| CN104068403A (en) * | 2014-07-04 | 2014-10-01 | 张海龙 | Capsule containing staminate flower power of eucommia ulmoides |
| CN104187379A (en) * | 2014-08-31 | 2014-12-10 | 梁世安 | Health noodles |
-
2018
- 2018-07-05 CN CN201810729997.2A patent/CN108851054A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101564124A (en) * | 2009-05-27 | 2009-10-28 | 云南省林业科学院 | Pelletizing method of pine pollen |
| CN104068403A (en) * | 2014-07-04 | 2014-10-01 | 张海龙 | Capsule containing staminate flower power of eucommia ulmoides |
| CN104187379A (en) * | 2014-08-31 | 2014-12-10 | 梁世安 | Health noodles |
Non-Patent Citations (4)
| Title |
|---|
| 福建三明地区真菌研究所药用研究室编辑: "《真菌试验 1981 药用菌专辑》", 31 December 1981, 福建省三明地区真菌研究所 * |
| 纪红兵等: "《天然香料健康图典》", 31 December 2017, 广东旅游出版社 * |
| 赵景联编著: "《科技致富新技术 实用生化产品制造50例》", 31 December 1993, 西安交通大学出版社 * |
| 钟赣生编等: "《中药学》", 31 May 2012, 中国中医药出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112568397A (en) * | 2020-12-04 | 2021-03-30 | 浙江蓝美生物技术有限公司 | Blueberry powder compound solid preparation capable of improving sleep and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101073370B (en) | Blackthorn pear products and its production | |
| CN101073433A (en) | Blackthorn pear fruit-juice solid product and its production | |
| CN103585261A (en) | Maca ginseng tablet and preparation method thereof | |
| CN1871932A (en) | Method for preparing climbing fig seed glue and gel powder of climbing fig seed glue | |
| CN104152521A (en) | Paeonia suffruticosa pollen protein polypeptide and preparation method and application thereof | |
| JP2003192605A (en) | Lipase inhibitant | |
| CN104000127A (en) | Green bean cooling and throat refreshing chewable tablets and production method thereof | |
| CN1287848A (en) | Method for extracting nutrition essence from bamboo, and series products thereof | |
| EP4115895A1 (en) | Tea composition having efficacy for preventing or improving respiratory diseases, and pharmaceutical composition comprising same | |
| CN104336230A (en) | Mulberry leaf sweet tea and preparation method thereof | |
| CN100496525C (en) | Technique of extracting acitve ingredient from roots, stems and leaves from artichoke and application | |
| KR102042798B1 (en) | A method for preparing functional pills comprising extracts of natural materials | |
| KR20210063657A (en) | A natural tea removing the effect of hangover contained the extract material in Hovenia dulcis and a cactus | |
| CN108813501B (en) | Health-preserving honey paste with functions of clearing heat, moistening lung, relieving cough, reducing phlegm, relieving asthma and regulating human body functions | |
| CN101554242A (en) | Honeysuckle drink and processing technique thereof | |
| CN106343489A (en) | Processing method of black peanut with pure natural plant formula | |
| CN103734767B (en) | Health-care food | |
| CN108851054A (en) | A kind of eucommia Bark male flower chewable tablets and preparation method thereof | |
| CN106579410A (en) | Maca, ginseng and Lycium ruthenicum Murr. tablet and preparation method thereof | |
| CN106511558A (en) | Traditional Chinese medicine composition for relieving coughs and reducing sputum and bergamot fruit sweetend roll | |
| CN105994840A (en) | Antihypertensive health-care tea containing dendrobium officinale and preparation method of tea | |
| CN105558767A (en) | Production method of root of kudzu vine nutrient health care rice flour | |
| CN1098918A (en) | Leaves-of-eucommia natural health-care products and production technology thereof | |
| KR101316090B1 (en) | Health assistance food using abalone shell and manufacturing method thereof | |
| CN108142619A (en) | A kind of Tartary buckwheat health-care tea and its processing technology |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181123 |