CN101869287B - Astragalus and honey soft capsule and preparation method thereof - Google Patents
Astragalus and honey soft capsule and preparation method thereof Download PDFInfo
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- CN101869287B CN101869287B CN2009100718938A CN200910071893A CN101869287B CN 101869287 B CN101869287 B CN 101869287B CN 2009100718938 A CN2009100718938 A CN 2009100718938A CN 200910071893 A CN200910071893 A CN 200910071893A CN 101869287 B CN101869287 B CN 101869287B
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- astragalus
- propolis
- bee pollen
- royal jelly
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- 150000003505 terpenes Chemical class 0.000 description 1
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- 230000035922 thirst Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
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- 230000029663 wound healing Effects 0.000 description 1
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- Jellies, Jams, And Syrups (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention belongs to the field of biotechnology, in particular to an astragalus and honey soft capsule and a preparation method thereof. The preparation method comprises the following steps: taking astragalus produced at Greater Higgnan Mountains, schisandra chinensis, propolis, bee pollen and royal jelly as raw materials; using vacuum freeze-drying, ultra-fine comminuting, ultrasonic extraction and an enzymatic hydrolysis technology in a biological engineering to fully extract and retain nutritional hygiene factors; then fully mixing astragalus extractions, propolis extractions, bee pollen peptide productions, lyophilized powder of oyal jelly and vegetable oil according to the proportion of 3:3:1:1:1:1; making the capsule, washing the capsule and drying; sampling and analyzing indexes of astragaloside, deoxyschizandrin, total flavonoids, protein, 10- hydroxyl-2-decenoic acid, wherein the analysis results are within ranges; and after passing the inspection, bottling, labeling, boxing, packaging and obtaining a product.
Description
Technical field
The invention belongs to high-technology field, specifically a kind of the Daxing'an Mountainrange real estate Radix Astragali, the fruit of Chinese magnoliavine, propolis, Bee Pollen, royal jelly are utilized vacuum freeze drying, ultra-fine grinding, ultrasonic extraction and bioengineering enzymolysis technology, fully extract and the reservation nutrition and health care factor, reasonable compatibility, realize that the trophic factors polymerization is living new, outstanding additive effect is made soft capsule dosage form and preparation method thereof.
The raw materials used Radix Astragali of this product, the fruit of Chinese magnoliavine are among the virgin forest from Daxing'an Mountainrange.Here being located between north latitude 50 degree～53 degree, is a natural pure land, and day and night temperature is large, is fit to the growth of the fruit of Chinese magnoliavine.Here vegetation is in great numbers, and species are abundant.On 8.4 ten thousand square kilometres soil, thousands of kinds of wild plants are arranged.
Propolis, Bee Pollen, royal jelly are national standardization agricultural product from a national class Agricultural Standardized Demonstration Area.
This products material all meets European Union's Organic Food Attestation and organizes organic foodstuff production, processing criterion, is safe functional nutrient health food.
Background technology
The Radix Astragali is perennial herb, about 1 meter of plant height.1-2 centimetre of main root diameter, length can reach more than 1 meter, and straight cutting enters the soil depths.The aerial stem of plant is upright, the tool rib; Become mildewed.The leaf alternate, odd number plumage compound leaf, tool leaflet 21-31 sheet.Leaflet is oval, long 7-30 millimeter, and wide 4-12 millimeter, tip circle or nick, base portion is circular.The stipule lanceolar, long 6 millimeters.Raceme is given birth to stem top axil, every inflorescence 10-20.Spend faint yellow, the crown of papilionaceous flower, the vexil obovate, the top nick, ala and fossil fragments are closely isometric.Ovary has handle, spends rear pod to expand, Long Circle, long 2-3 centimetre, there is short beak on the top, fruit is outward by undercoat, in seed 3-8 grain is arranged.
Radix Astragali slightly warm in nature, it is sweet to distinguish the flavor of, and the effect of invigorating qi for strengthening superficies, hidroschesis detoxification, myogenic, diuresis, detumescence is arranged.It is weak to be used for the treatment of the deficiency of vital energy, and the sinking of qi of middle-jiao is rushed down prolapse of the anus for a long time, the uterine bleeding of having blood in stool, and the exterior deficiency spontaneous perspiration, ulcer is difficult bursts, and bursts for a long time and does not hold back, and the deficiency of blood is sallow, and interior heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The Radix Astragali is rare traditional Chinese medicine, originates in China North China, northeast, the Inner Mongol and northwest, main product in Shanxi, the province such as Heilungkiang, Liaoning, Hebei.
The fruit of Chinese magnoliavine is commonly called as mountain flower green pepper, sliding weight of steelyard, the medicine fruit of Chinese magnoliavine, face rattan, five plums etc., ancient medical book Cheng Ta Chi Zhu, profound and, can and.Fruit for magnoliaceae schisandra.Perennial fallen leaves liana.Fruit is practised and is claimed " fructus schisandrae ", hyoscine.The ground such as Northeast China, North China has wild or cultivation.
Schisandra fruit implementation Chinese medicine function nourishing generate fluid, the nourshing kidney of astringing the lung, antidiarrheal, puckery essence, calm the nerves, can control that chronic cough void is breathed heavily, the diseases such as the few dry in Tianjin, seminal emission are rushed down for a long time, forgetful insomnia.The pharmacological testing proof can be regulated excitement and the process of inhibition of central nervous system, promotes body metabolism, regulates the secretion of gastric juice and bile, and rising person has reducing effect to hepatitis convalescence transaminase.Pericarp and the ripe skin of planting contain lignanoid, are the effective medicinal components of the fruit of Chinese magnoliavine, comprising multiple schizandrin.Seed is fatty, but grease soap system or machine oil.Cauline leaf and seed all can extract aromatic oil.
The propolis resin (natural gum) that to be honeybee gather from plant gemma or trunk is sneaked into the secretion of body of gland in the honeybee mouthpart, and a kind of colloid substance of being processed into pollen, beeswax again is the umbrella of honeycomb.One 5～60,000 bee colony can only produce propolis 100-150 gram in 1 year, was described as " purple gold ".
The amino acid, the B family vitamin that contain trace in the propolis, abundant mineral matter and trace element, multiple organic acid, terpenoid and the flavone compound more than 70 kinds.Have broad-spectrum antiseptic, anti-inflammatory, anticancer, analgesic activity, can strengthen some antibiotic, promote histocyte regeneration, can triglyceride reducing, again can norcholesterol, gastric ulcer there is therapeutic action, strengthen immunologic function, the nutrition skin delays senility.
Bee Pollen is the male sex-cell in the flowering plant stamen, and it is not only carrying the hereditary information of life, and is comprising and breed the necessary complete nutrients matter of new life, be plant produce a male heir to continue the family line basic, the source of heat energy.Bee Pollen is the pollen load that is processed into through honeybee by the pollen that honeybee gathers from plant flowers, being described as " all-round nutraceutical ", " concentrated natural Drug Storage ", " all-round nutrition library ", " cosmetics for oral administration ", " concentrated amino acid " etc., is " rarity in the human wholefood ".
Bee Pollen contains the multiple nutrients material, comprising 22 seed amino acids, 14 kinds of vitamin and 30 various trace elements and a large amount of active protease, nucleic acid, flavone compound and other active materials.The protein that Bee Pollen is rich in exists mainly with the form of free amino acid, and content surpasses milk, egg 5-7 times; Ascorbic content is higher than fresh fruit and vegetables, is called as " king of natural complex ".
Bee Pollen can be prevented and treated brain cardiovascular disease, and nervous system is regulated in reducing blood lipid, promotes sleep, regulates the gastronintestinal system function, promotes digestion, the treatment habitual constipation; Regulate endocrine, improve body's immunity, anti-ageing, improve the aspects such as sexual function, treatment male sterility certain effect arranged; Particularly treat male prostatitis, hypertrophy of the prostate has obvious curative effect.Just can improve symptom in a short period of time.Also have obvious anti-cancer tumor suppressor and liver protecting, prevent anaemia, the function such as diabetes, antifatigue.In addition, the cosmetic result of Bee Pollen is obvious.
Royal jelly has another name called bee milk, royal jelly, is the secretion of cultivating young worker bee (nurse honeybee) the pharynx gland of larva in the honeycomb.The food of supplying with the larva that will become queen bee.Contain protein, fat, carbohydrate, vitamin A, Cobastab in the royal jelly
1, Cobastab
2, abundant folic acid, pantothenic acid, aliphatic acid and alcohols, also have similar acetylcholine sample material, and the amino acid that needs of multiple human body and bio-hormone etc.
The nutritionist thinks, royal jelly is unique super nutritive food for the human high activity composition of directly taking in the world.The personages of state the world of medicine such as American and Britain, method, moral, meaning, day sum up royal jelly ten large effects:
1, royal jelly contains acetylcholine, can make vegetative nerve recover normal, and is remarkable to treatment cardiovascular disease effect, has the effect of good adjusting blood fat;
2, royal jelly is rich in Cobastab and good protein, particularly contains the strong royal jelly acid of sterilizing power, thereby is good medicine for cancer;
3, royal jelly has the effect of the hematopoiesis function of promotion, can increase hemoglobin to developmental children, promotes growth, improves premunition;
4, royal jelly contains pantothenic acid, can improve rheumatism and joint symptom;
5, royal jelly contains para-insulin, and diabetes are had better effects;
6, royal jelly can be strengthened the adrenal cortex function, the balance the body hormone, and brain cell between activation is conducive to treat climacteric disfunction and chronic prostatitis syndrome;
7, royal jelly can strengthen people's basis muscle power, makes the activation of human senility tissue, and appetite is good behind the clothes, long spirit, and complexion is good;
8, the contained peptide of royal jelly and protein-based healthy ingredient can promote intellectual development, thereby take and can improve memory;
9, royal jelly contains proteohormone, with the blood circulation whole body, helps skin histology functional recovery vigor behind the clothes, and successful is scalded in treatment;
10, royal jelly contains plurality of inorganic salt, can promote glycogen to discharge, and promotes metabolism, thereby can improve looks, and eliminates speckle.
Through for many years scientific research and clinical medicine facts have proved both at home and abroad, royal jelly has peculiar effect to human medical treatment, health care etc., can improve nutrition, additional mentality, raising body immunity, prophylactic treatment cardiovascular and cerebrovascular disease, treatment anaemia, anti-inflammatory, pain relieving, promotion wound healing, pre-anti-cancer, beauty treatment;
In a word, the Radix Astragali, the fruit of Chinese magnoliavine, propolis, Bee Pollen, royal jelly, be a human important nutrient source.But generally all be at present independent use, also do not have the composite use of discovery science, therefore, have antifatigue effect, regulate the astragalus and honey soft capsule of immunologic function by exploitation, can advance bee product and the composite use of other resource, improve the Science Explorations of health-care effect.
Summary of the invention
Purpose of the present invention is exactly to better meet society to the demand of nutrition and health care product, solve the dose-effect relationship of the Radix Astragali, the fruit of Chinese magnoliavine, propolis, Bee Pollen, royal jelly reasonable compatibility, realize that the trophic factors polymerization is living new, outstanding additive effect, and be made into the method that has antifatigue effect, regulates the health-care effect food of immunologic function.
Astragalus and honey soft capsule of the present invention is a kind of the Daxing'an Mountainrange real estate Radix Astragali, the fruit of Chinese magnoliavine, propolis, Bee Pollen, royal jelly to be utilized vacuum freeze drying, ultra-fine grinding, ultrasonic extraction and bioengineering enzymolysis technology, fully extract and the reservation nutrition and health care factor, the dose-effect relationship of reasonable compatibility, realize that the trophic factors polymerization is living new, outstanding additive effect, the refining health-care effect food with antifatigue effect, adjusting immunologic function that forms.
The preparation method of astragalus and honey soft capsule of the present invention is:
1, the Radix Astragali and the fruit of Chinese magnoliavine selected separately, impurity elimination, cleaned, carries out ultra-fine grinding after the vacuum drying, use the ultrasonic extraction technology to extract behind the functional component to such an extent that extract is for subsequent use;
2, propolis is removed impurity, pulverize after freezing, adopt the ultrasonic extraction technology to extract behind the functional component to such an extent that extract is for subsequent use;
3, Bee Pollen selected, pulverize after the impurity elimination, added the pollen weight 40% water rear freezing 24h that stirs, add immediately after the taking-up pollen weight 160% hot water stir dissolve, homogeneous, enzymolysis, behind the one-step palletizing the Bee Pollen Gly-His-Lys is for subsequent use;
4, royal jelly is thawed, filter out the impurity such as beeswax, it is for subsequent use to use vacuum freeze drying, ultra-fine grinding technology to make behind the fine particle state freeze-dried powder;
5, will be according to Astragalus Root P.E: Schisandra chinens P.E: propolis extract: Bee Pollen Gly-His-Lys: royal jelly freeze-dried powder: vegetable oil 3: 3: 1: 1: 1: 1 ratio be fully mixed rear capsule processed, washes capsule, drying, and after the assay was approved bottling, vanning gets product.
This astragalus and honey soft capsule is through national agricultural standardization network center (Heilungkiang) check, and the result is: according to checking under Radix Astragali item of Pharmacopoeia of People's Republic of China, Astragaloside IV is positive; According to checking under five tastes subitem of Pharmacopoeia of People's Republic of China, schizandrin A is positive; According to checking general flavone content 〉=2% under the propolis normal term; According to checking protein 〉=3% under the Bee Pollen normal term; According to checking 10-HAD content 〉=0.2% under the royal jelly national standard item.
The specific embodiment
Embodiment 1:
1, the Radix Astragali and the fruit of Chinese magnoliavine selected separately, impurity elimination, cleaned, carries out behind the vacuum extraction functional component to such an extent that extract is for subsequent use;
2, propolis is removed impurity, pulverize after freezing, adopt hot reflux to process to extract behind the functional component to such an extent that extract is for subsequent use;
3, Bee Pollen selected, pulverize after the impurity elimination, added the pollen weight 50% water rear freezing 24h that stirs, add immediately after the taking-up pollen weight 150% hot water stir dissolve, homogeneous, enzymolysis, behind the one-step palletizing the Bee Pollen Gly-His-Lys is for subsequent use;
4, royal jelly is thawed, filter out the impurity such as beeswax, it is for subsequent use to use vacuum freeze drying, ultra-fine grinding technology to make behind the fine particle state freeze-dried powder;
5, will be according to Astragalus Root P.E: Schisandra chinens P.E: propolis extract: Bee Pollen Gly-His-Lys: royal jelly freeze-dried powder: vegetable oil 3: 2: 2: 1: 1: 1 ratio be fully mixed rear capsule processed, washes capsule, drying, and after the assay was approved bottling, vanning gets product.
Embodiment 2:
1, the Radix Astragali and the fruit of Chinese magnoliavine selected separately, impurity elimination, cleaned, carries out behind the vacuum extraction functional component to such an extent that extract is for subsequent use;
2, propolis is removed impurity, pulverize after freezing, adopt and leave standstill lixiviate and extract behind the functional component to such an extent that extract is for subsequent use;
3, Bee Pollen selected, pulverize after the impurity elimination, added the pollen weight 40% water rear freezing 24h that stirs, add immediately after the taking-up pollen weight 150% hot water stir dissolve, homogeneous, enzymolysis, behind the one-step palletizing the Bee Pollen Gly-His-Lys is for subsequent use;
4, royal jelly is thawed, filter out the impurity such as beeswax, it is for subsequent use to use vacuum freeze drying, ultra-fine grinding technology to make behind the fine particle state freeze-dried powder;
5, will be according to Astragalus Root P.E: Schisandra chinens P.E: propolis extract: Bee Pollen Gly-His-Lys: royal jelly freeze-dried powder: vegetable oil 3: 2: 2: 1: 1: 1 ratio be fully mixed rear capsule processed, washes capsule, drying, and after the assay was approved bottling, vanning gets product.
Embodiment 3:
1, the Radix Astragali and the fruit of Chinese magnoliavine selected separately, impurity elimination, cleaned, carries out behind the vacuum extraction functional component to such an extent that extract is for subsequent use;
2, propolis is removed impurity, pulverize after freezing, adopt the ultrasonic extraction technology to extract behind the functional component to such an extent that extract is for subsequent use;
3, Bee Pollen selected, pulverize after the impurity elimination, added the pollen weight 40% water rear freezing 24h that stirs, add immediately after the taking-up pollen weight 160% hot water stir dissolve, homogeneous, enzymolysis, behind the one-step palletizing the Bee Pollen Gly-His-Lys is for subsequent use;
4, royal jelly is thawed, filter out the impurity such as beeswax, it is for subsequent use to use vacuum freeze drying, ultra-fine grinding technology to make behind the fine particle state freeze-dried powder;
5, will be according to Astragalus Root P.E: Schisandra chinens P.E: propolis extract: Bee Pollen Gly-His-Lys: royal jelly freeze-dried powder: vegetable oil 3: 3: 1: 1: 1: 1 ratio be fully mixed rear capsule processed, washes capsule, drying, and after the assay was approved bottling, vanning gets product.
Embodiment 4:
1, the Radix Astragali and the fruit of Chinese magnoliavine selected separately, impurity elimination, cleaned, carries out ultra-fine grinding after the vacuum drying, use the ultrasonic extraction technology to extract behind the functional component to such an extent that extract is for subsequent use;
2, propolis is removed impurity, pulverize after freezing, adopt the ultrasonic extraction technology to extract behind the functional component to such an extent that extract is for subsequent use;
3, Bee Pollen selected, pulverize after the impurity elimination, added the pollen weight 40% water rear freezing 24h that stirs, add immediately after the taking-up pollen weight 160% hot water stir dissolve, homogeneous, enzymolysis, behind the one-step palletizing the Bee Pollen Gly-His-Lys is for subsequent use;
4, royal jelly is thawed, filter out the impurity such as beeswax, it is for subsequent use to use vacuum freeze drying, ultra-fine grinding technology to make behind the fine particle state freeze-dried powder;
5, will be according to Astragalus Root P.E: Schisandra chinens P.E: propolis extract: Bee Pollen Gly-His-Lys: royal jelly freeze-dried powder: vegetable oil 3: 2: 2: 1: 1: 1 ratio be fully mixed rear capsule processed, washes capsule, drying, and after the assay was approved bottling, vanning gets product.
Embodiment 5:
1, the Radix Astragali and the fruit of Chinese magnoliavine selected separately, impurity elimination, cleaned, carries out ultra-fine grinding after the vacuum drying, use the ultrasonic extraction technology to extract behind the functional component to such an extent that extract is for subsequent use;
2, propolis is removed impurity, pulverize after freezing, adopt the ultrasonic extraction technology to extract behind the functional component to such an extent that extract is for subsequent use;
3, Bee Pollen selected, pulverize after the impurity elimination, added the pollen weight 40% water rear freezing 24h that stirs, add immediately after the taking-up pollen weight 160% hot water stir dissolve, homogeneous, enzymolysis, behind the one-step palletizing the Bee Pollen Gly-His-Lys is for subsequent use;
4, royal jelly is thawed, filter out the impurity such as beeswax, it is for subsequent use to use vacuum freeze drying, ultra-fine grinding technology to make behind the fine particle state freeze-dried powder;
5, will be according to Astragalus Root P.E: Schisandra chinens P.E: propolis extract: Bee Pollen Gly-His-Lys: royal jelly freeze-dried powder: vegetable oil 3: 3: 1: 1: 1: 1 ratio be fully mixed rear capsule processed, washes capsule, drying, and after the assay was approved bottling, vanning gets product.
Claims (1)
1. astragalus and honey soft capsule, it is characterized in that the Daxing'an Mountainrange real estate Radix Astragali, the fruit of Chinese magnoliavine, propolis, Bee Pollen, royal jelly reasonable compatibility, utilize vacuum freeze drying, ultra-fine grinding, ultrasonic extraction and bioengineering enzymolysis technology, fully extract and the reservation nutrition and health care factor, realize that the trophic factors polymerization is living new, outstanding additive effect, make soft capsule dosage form, Astragaloside IV is positive in the product, schizandrin A is positive, general flavone content 〉=2%, protein 〉=3%, 10-HAD content 〉=0.2%, the preparation method of this kind astragalus and honey soft capsule is:
(1), the Radix Astragali and the fruit of Chinese magnoliavine are selected separately, impurity elimination, cleaned, carry out ultra-fine grinding after the vacuum drying, use the ultrasonic extraction technology to extract behind the functional component to such an extent that extract is for subsequent use;
(2), propolis is removed impurity, pulverize after freezing, adopt the ultrasonic extraction technology to extract behind the functional component to such an extent that extract is for subsequent use;
(3), Bee Pollen is selected, pulverize after the impurity elimination, add the pollen weight 40% water rear freezing 24h that stirs, add immediately pollen weight 160% hot water after the taking-up and stir thawing, homogeneous, enzymolysis, behind the one-step palletizing the Bee Pollen Gly-His-Lys is for subsequent use;
(4) royal jelly is thawed, filter out the impurity such as beeswax, use vacuum freeze drying, it is for subsequent use that the ultra-fine grinding technology is made fine particle state freeze-dried powder;
(5), according to Astragalus Root P.E: Schisandra chinens P.E: propolis extract: Bee Pollen Gly-His-Lys: royal jelly freeze-dried powder: vegetable oil 3: 3: 1: 1: 1: 1 ratio is fully mixed rear capsule processed, wash capsule, drying, after the assay was approved bottling, vanning gets product.
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| CN102823792B (en) * | 2012-08-28 | 2013-09-11 | 安徽省王巢食品有限公司 | Soft propolis astragalus mongholicus capsule and preparation method thereof |
| CN103181930B (en) * | 2013-03-16 | 2016-04-13 | 西北大学 | Fructus Schisandrae Chinensis effective part of bee pollen form and the application in prevention hepar damnification thereof |
| CN104906243A (en) * | 2015-05-25 | 2015-09-16 | 上海焦点生物技术有限公司 | Traditional Chinese medicine compound with liver protection function |
| CN105395677A (en) * | 2015-11-20 | 2016-03-16 | 武汉思维特食品有限公司 | Royal jelly, propolis and Chinese magnoliavine fruit capsule and preparation method thereof |
| CN107736596A (en) * | 2017-10-23 | 2018-02-27 | 佛山科学技术学院 | A kind of royal jelly capsule for improving memory function and preparation method thereof |
| CN108294269A (en) * | 2018-01-30 | 2018-07-20 | 叶水华 | A kind of strengthen immunity and health care capsule used for relieving physical fatigue production method |
| CN108938673A (en) * | 2018-08-22 | 2018-12-07 | 赵丽静 | A kind of drug and preparation method thereof for treating otitis media suppurative |
| CN118489858A (en) * | 2024-06-06 | 2024-08-16 | 江苏蜂奥生物科技有限公司 | A propolis nutritional composition with high bioavailability and preparation method thereof |
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| CN1430982A (en) * | 2003-01-13 | 2003-07-23 | 徐春华 | Capsule of astragalus and honey as well as its preparing technique |
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