CN101869287A - Astragalus and honey soft capsule and preparation method thereof - Google Patents
Astragalus and honey soft capsule and preparation method thereof Download PDFInfo
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- CN101869287A CN101869287A CN200910071893A CN200910071893A CN101869287A CN 101869287 A CN101869287 A CN 101869287A CN 200910071893 A CN200910071893 A CN 200910071893A CN 200910071893 A CN200910071893 A CN 200910071893A CN 101869287 A CN101869287 A CN 101869287A
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Abstract
The invention belongs to the field of biotechnology, in particular to an astragalus and honey soft capsule and a preparation method thereof. The preparation method comprises the following steps: taking astragalus produced at Greater Higgnan Mountains, schisandra chinensis, propolis, bee pollen and royal jelly as raw materials; using vacuum freeze-drying, ultra-fine comminuting, ultrasonic extraction and an enzymatic hydrolysis technology in a biological engineering to fully extract and retain nutritional hygiene factors; then fully mixing astragalus extractions, propolis extractions, bee pollen peptide productions, lyophilized powder of oyal jelly and vegetable oil according to the proportion of 3:3:1:1:1:1; making the capsule, washing the capsule and drying; sampling and analyzing indexes of astragaloside, deoxyschizandrin, total flavonoids, protein, 10- hydroxyl-2-decenoic acid, wherein the analysis results are within ranges; and after passing the inspection, bottling, labeling, boxing, packaging and obtaining a product.
Description
Technical field
The invention belongs to high-technology field, specifically be a kind of the Daxing'an Mountainrange real estate Radix Astragali, the fruit of Chinese magnoliavine, propolis, melissa powder, royal jelly to be utilized vacuum freeze drying, ultra-fine grinding, ultrasonic extraction and bioengineering enzymolysis technology, fully extract and the reservation nourishing healthy factor, reasonable compatibility, realize that the trophic factors polymerization is living new, outstanding additive effect is made soft capsule dosage form and preparation method thereof.
The raw materials used Radix Astragali of this product, the fruit of Chinese magnoliavine are among the virgin forest from Daxing'an Mountainrange.Here being located between north latitude 50 degree～53 degree, is a natural pure land, and day and night temperature is big, is fit to the growth of the fruit of Chinese magnoliavine.Here vegetation is in great numbers, and species are abundant.On 8.4 ten thousand square kilometres soil, thousands of kinds of wild plants are arranged.
Propolis, melissa powder, royal jelly are national standardization agricultural product from a national class agricultural standardization demonstration area.
This products material all meets the production of organic food qualification organization of European Union organic food, processing criterion, is the safe functioning nutritional health food.
Background technology
The Radix Astragali is a perennial herb, about 1 meter of plant height.1-2 centimetre of main root diameter, length can reach more than 1 meter, and straight cutting is gone into the soil depths.The aerial stem of plant is upright, the tool rib; Become mildewed.The leaf alternate, odd number plumage compound leaf, tool leaflet 21-31 sheet.The leaflet ellipse, long 7-30 millimeter, wide 4-12 millimeter, tip circle or nick, base portion circle.The stipule lanceolar, long 6 millimeters.Raceme is given birth to stem top axil, every inflorescence 10-20.Spend faint yellow, the crown of papilionaceous flower, the vexil obovate, the top nick, ala and fossil fragments are closely isometric.Ovary has handle, spends the back pod to expand, Long Circle, long 2-3 centimetre, there is short beak on the top, fruit is outer by undercoat, in seed 3-8 grain is arranged.
Radix Astragali slightly warm in nature, it is sweet to distinguish the flavor of, and the effect of invigorating qi for strengthening superficies, hidroschesis detoxification, myogenic, diuresis, detumescence is arranged.It is weak to be used for the treatment of the deficiency of vital energy, and the sinking of qi of middle-jiao is rushed down prolapse of the anus for a long time, the uterine bleeding of having blood in stool, and the exterior deficiency spontaneous perspiration, ulcer is difficult bursts, and bursts for a long time and does not hold back, and the deficiency of blood is sallow, and interior heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.The Radix Astragali is a rare traditional Chinese medicine, originates in China North China, northeast, the Inner Mongol and northwest, main product in Shanxi, province such as Heilungkiang, Liaoning, Hebei.
The fruit of Chinese magnoliavine is commonly called as mountain flower green pepper, sliding weight of steelyard, the medicine fruit of Chinese magnoliavine, face rattan, five plums etc., ancient medical book Cheng Ta Chi Zhu, profound and, can and.Fruit for magnoliaceae schisandra.Perennial fallen leaves liana.Fruit is practised and is claimed " fructus schisandrae ", hyoscine.Ground such as Northeast China, North China all has wild or cultivation.
Schisandra fruit is made Chinese medicine function nourishing generate fluid, the nourshing kidney of astringing the lung, antidiarrheal, puckery essence, is calmed the nerves, and can control diseases such as chronic cough void is breathed heavily, dry is lacked in Tianjin, seminal emission is rushed down for a long time, forgetful insomnia.The pharmacological testing proof can be regulated the excitement and the process of inhibition of central nervous system, promotes body metabolism, regulates the secretion of gastric juice and bile, and rising person has the reduction effect to hepatitis convalescence transaminase.Pericarp and the ripe skin of planting contain lignanoid, are the effective medicinal components of the fruit of Chinese magnoliavine, comprising multiple schizandrin.Seed is fatty, but grease soap system or machine oil.Cauline leaf and seed all can extract aromatic oil.
The propolis resin (natural gum) that to be honeybee gather from plant gemma or trunk is sneaked into the secretion of body of gland in the honeybee mouthpart, and a kind of colloid substance of being processed into pollen, beeswax is the umbrella of honeycomb again.One 5～60,000 bee colony can only produce propolis 100-150 gram in 1 year, was described as " purple gold ".
The amino acid, the B family vitamin that contain trace in the propolis, abundant mineral matter and trace element, multiple organic acid, terpenoid and the flavone compound more than 70 kinds.Have broad-spectrum antiseptic, anti-inflammatory, anticancer, analgesic activity, can strengthen some antibiotic, promote histocyte regeneration, can triglyceride reducing, again can norcholesterol, gastric ulcer there is therapeutic action, strengthen immunologic function, the nutrition skin delays senility.
The melissa powder is the male sex-cell in the flowering plant stamen, and it is not only carrying the hereditary information of life, and is comprising and breed the necessary complete nutrients matter of new life, be plant produce a male heir to continue the family line basic, the source of heat energy.The melissa powder is the pollen load that is processed into through honeybee by the pollen that honeybee is gathered from plant flowers, being described as " all-round nutraceutical ", " the natural Drug Storage that concentrates ", " all-round nutrition library ", " cosmetics for oral administration ", " amino acid that concentrates " etc., is " rarity in the human wholefood ".
The melissa powder contains the multiple nutrients material, comprising 22 seed amino acids, 14 kinds of vitamin and 30 various trace elements and a large amount of active protease, nucleic acid, flavone compound and other active materials.The many forms with free amino acid of the protein that the melissa powder is rich in exist, and content surpasses milk, egg 5-7 times; Ascorbic content is higher than fresh fruit and vegetables, is called as " king of natural complex ".
The melissa powder can be prevented and treated brain cardiovascular disease, and nervous system is regulated in reducing blood lipid, promotes sleep, regulates the gastronintestinal system function, promotes digestion, the treatment habitual constipation; Regulate endocrine, improve body's immunity, anti-ageing, improve aspects such as sexual function, treatment male sterility certain effect arranged; Particularly treat male prostatitis, hypertrophy of the prostate has tangible curative effect.Just can improve symptom in a short period of time.Also have tangible anti-cancer tumor suppressor and liver protecting, prevent anaemia, function such as diabetes, antifatigue.In addition, the cosmetic result of melissa powder is obvious.
Royal jelly has another name called bee milk, royal jelly, is the secretion of cultivating young worker bee (nurse honeybee) the pharynx gland of larva in the honeycomb.Be the food of supplying with the larva that will become queen bee.Contain protein, fat, carbohydrate, vitamin A, Cobastab in the royal jelly
1, Cobastab
2, abundant folic acid, pantothenic acid, aliphatic acid and alcohols, also have similar acetylcholine sample material, and the amino acid that needs of multiple human body and bio-hormone etc.
The nutritionist thinks that royal jelly is unique in the world super nutritive food for the human high activity composition of directly taking.The personages of state the world of medicine such as American and Britain, method, moral, meaning, day sum up royal jelly ten large effects:
1, royal jelly contains acetylcholine, can make vegetative nerve recover normal, and is remarkable to treatment cardiovascular disease effect, has the effect of good adjusting blood fat;
2, royal jelly is rich in Cobastab and good protein, particularly contains the strong royal jelly acid of sterilizing power, thereby for controlling cancer good medicine;
3, royal jelly has the effect of the hematopoiesis function of promotion, can increase hemoglobin to developmental children, promotes growth, improves premunition;
4, royal jelly contains pantothenic acid, can improve rheumatism and joint symptom;
5, royal jelly contains para-insulin, and diabetes are had better effects;
6, royal jelly can be strengthened the adrenal cortex function, regulates the human hormone, and brain cell between activation helps treating climacteric disfunction and chronic prostatitis syndrome;
7, royal jelly can strengthen people's basis muscle power, makes the activation of human senility tissue, and clothes back appetite is good, long spirit, and complexion is good;
8, contained peptide of royal jelly and protein-based healthy ingredient can promote intellectual development, thereby take and can improve memory;
9, royal jelly contains proteohormone, and the clothes back helps skin histology functional recovery vigor with the blood circulation whole body, and is obvious to treatment scald effect;
10, royal jelly contains plurality of inorganic salt, can promote glycogen to discharge, and promotes metabolism, thereby can improve looks, and eliminates speckle.
Through scientific research for many years and clinical medicine facts have proved both at home and abroad, royal jelly has peculiar effect to human medical treatment, health care etc., can improve nutrition, additional mentality, raising body immunity, prophylactic treatment cardiovascular and cerebrovascular disease, treatment anaemia, anti-inflammatory, pain relieving, promotion wound healing, pre-anti-cancer, beauty treatment;
In a word, the Radix Astragali, the fruit of Chinese magnoliavine, propolis, melissa powder, royal jelly, be a human important nutrient source.But generally all be independent use at present, also do not find the composite use of science, therefore, have antifatigue effect, regulate the astragalus and honey soft capsule of immunologic function by exploitation, can advance bee product and the composite use of other resource, improve the Science Explorations of health-care effect.
Summary of the invention
Purpose of the present invention is exactly to better meet the demand of society to the nourishing healthy product, solve the dose-effect relationship of the Radix Astragali, the fruit of Chinese magnoliavine, propolis, melissa powder, royal jelly reasonable compatibility, realize that the trophic factors polymerization is living new, outstanding additive effect, and be made into the method that has antifatigue effect, regulates the health-care effect food of immunologic function.
Astragalus and honey soft capsule of the present invention is a kind of the Daxing'an Mountainrange real estate Radix Astragali, the fruit of Chinese magnoliavine, propolis, melissa powder, royal jelly to be utilized vacuum freeze drying, ultra-fine grinding, ultrasonic extraction and bioengineering enzymolysis technology, fully extract and the reservation nourishing healthy factor, the dose-effect relationship of reasonable compatibility, realize that the trophic factors polymerization is living new, outstanding additive effect, the refining health-care effect food that forms with antifatigue effect, adjusting immunologic function.
The preparation method of astragalus and honey soft capsule of the present invention is:
1, the Radix Astragali and the fruit of Chinese magnoliavine selected separately, impurity elimination, cleaned, carry out ultra-fine grinding after the vacuum drying, utilization ultrasonic extraction technology is extracted behind the functional component to such an extent that extract is standby;
2, propolis is removed impurity, pulverize after freezing, adopt the ultrasonic extraction technology to extract behind the functional component to such an extent that extract is standby;
3, the melissa powder selected, pulverize after the impurity elimination, added the pollen weight 40% water freezing 24h in back that stirs, add immediately after the taking-up pollen weight 160% hot water stir dissolve, homogeneous, enzymolysis, behind the one-step palletizing the bee pollen peptide powder is standby;
4, royal jelly is thawed, filter out impurity such as beeswax, the utilization vacuum freeze drying, the ultra-fine grinding technology is made behind the fine particle state freeze-dried powder standby;
5, will be according to Astragalus Root P.E: Schisandra chinens P.E: propolis extract: bee pollen peptide powder: royal jelly freeze-dried powder: vegetable oil 3: 3: 1: 1: 1: 1 ratio be fully mixed back system capsule, washes capsule, drying, bottling after the assay was approved, vanning, product.
This astragalus and honey soft capsule is through national agricultural standardization monitoring and research center (Heilungkiang) check, and the result is; According to the check down of Radix Astragali item of Pharmacopoeia of People's Republic of China, the Astragaloside IV positive; According to the check down of five tastes subitem of Pharmacopoeia of People's Republic of China, the schizandrin A positive; According to the check down of propolis normal term, general flavone content 〉=2%; According to the check down of melissa powder normal term, protein 〉=3%; According to the check down of royal jelly national standard item, 10-hydroxyl-2-decylenic acid content 〉=0.2%.
The specific embodiment
Embodiment 1:
1, the Radix Astragali and the fruit of Chinese magnoliavine selected separately, impurity elimination, cleaned, carries out behind the vacuum extraction functional component to such an extent that extract is standby;
2, propolis is removed impurity, pulverize after freezing, adopt hot reflux to handle to extract behind the functional component to such an extent that extract is standby;
3, the melissa powder selected, pulverize after the impurity elimination, added the pollen weight 50% water freezing 24h in back that stirs, add immediately after the taking-up pollen weight 150% hot water stir dissolve, homogeneous, enzymolysis, behind the one-step palletizing the bee pollen peptide powder is standby;
4, royal jelly is thawed, filter out impurity such as beeswax, the utilization vacuum freeze drying, the ultra-fine grinding technology is made behind the fine particle state freeze-dried powder standby;
5, will be according to Astragalus Root P.E: Schisandra chinens P.E: propolis extract: bee pollen peptide powder: royal jelly freeze-dried powder: vegetable oil 3: 2: 2: 1: 1: 1 ratio be fully mixed back system capsule, washes capsule, drying, bottling after the assay was approved, vanning, product.
Embodiment 2:
1, the Radix Astragali and the fruit of Chinese magnoliavine selected separately, impurity elimination, cleaned, carries out behind the vacuum extraction functional component to such an extent that extract is standby;
2, propolis is removed impurity, pulverize after freezing, adopt and leave standstill lixiviate and extract behind the functional component to such an extent that extract is standby;
3, the melissa powder selected, pulverize after the impurity elimination, added the pollen weight 40% water freezing 24h in back that stirs, add immediately after the taking-up pollen weight 150% hot water stir dissolve, homogeneous, enzymolysis, behind the one-step palletizing the bee pollen peptide powder is standby;
4, royal jelly is thawed, filter out impurity such as beeswax, the utilization vacuum freeze drying, the ultra-fine grinding technology is made behind the fine particle state freeze-dried powder standby;
5, will be according to Astragalus Root P.E: Schisandra chinens P.E: propolis extract: bee pollen peptide powder: royal jelly freeze-dried powder: vegetable oil 3: 2: 2: 1: 1: 1 ratio be fully mixed back system capsule, washes capsule, drying, bottling after the assay was approved, vanning, product.
Embodiment 3:
1, the Radix Astragali and the fruit of Chinese magnoliavine selected separately, impurity elimination, cleaned, carries out behind the vacuum extraction functional component to such an extent that extract is standby;
2, propolis is removed impurity, pulverize after freezing, adopt the ultrasonic extraction technology to extract behind the functional component to such an extent that extract is standby;
3, the melissa powder selected, pulverize after the impurity elimination, added the pollen weight 40% water freezing 24h in back that stirs, add immediately after the taking-up pollen weight 160% hot water stir dissolve, homogeneous, enzymolysis, behind the one-step palletizing the bee pollen peptide powder is standby;
4, royal jelly is thawed, filter out impurity such as beeswax, the utilization vacuum freeze drying, the ultra-fine grinding technology is made behind the fine particle state freeze-dried powder standby;
5, will be according to Astragalus Root P.E: Schisandra chinens P.E: propolis extract: bee pollen peptide powder: royal jelly freeze-dried powder: vegetable oil 3: 3: 1: 1: 1: 1 ratio be fully mixed back system capsule, washes capsule, drying, bottling after the assay was approved, vanning, product.
Embodiment 4:
1, the Radix Astragali and the fruit of Chinese magnoliavine selected separately, impurity elimination, cleaned, carry out ultra-fine grinding after the vacuum drying, utilization ultrasonic extraction technology is extracted behind the functional component to such an extent that extract is standby;
2, propolis is removed impurity, pulverize after freezing, adopt the ultrasonic extraction technology to extract behind the functional component to such an extent that extract is standby;
3, the melissa powder selected, pulverize after the impurity elimination, added the pollen weight 40% water freezing 24h in back that stirs, add immediately after the taking-up pollen weight 160% hot water stir dissolve, homogeneous, enzymolysis, behind the one-step palletizing the bee pollen peptide powder is standby;
4, royal jelly is thawed, filter out impurity such as beeswax, the utilization vacuum freeze drying, the ultra-fine grinding technology is made behind the fine particle state freeze-dried powder standby;
5, will be according to Astragalus Root P.E: Schisandra chinens P.E: propolis extract: bee pollen peptide powder: royal jelly freeze-dried powder: vegetable oil 3: 2: 2: 1: 1: 1 ratio be fully mixed back system capsule, washes capsule, drying, bottling after the assay was approved, vanning, product.
Embodiment 5:
1, the Radix Astragali and the fruit of Chinese magnoliavine selected separately, impurity elimination, cleaned, carry out ultra-fine grinding after the vacuum drying, utilization ultrasonic extraction technology is extracted behind the functional component to such an extent that extract is standby;
2, propolis is removed impurity, pulverize after freezing, adopt the ultrasonic extraction technology to extract behind the functional component to such an extent that extract is standby;
3, the melissa powder selected, pulverize after the impurity elimination, added the pollen weight 40% water freezing 24h in back that stirs, add immediately after the taking-up pollen weight 160% hot water stir dissolve, homogeneous, enzymolysis, behind the one-step palletizing the bee pollen peptide powder is standby;
4, royal jelly is thawed, filter out impurity such as beeswax, the utilization vacuum freeze drying, the ultra-fine grinding technology is made behind the fine particle state freeze-dried powder standby;
5, will be according to Astragalus Root P.E: Schisandra chinens P.E: propolis extract: bee pollen peptide powder: royal jelly freeze-dried powder: vegetable oil 3: 3: 1: 1: 1: 1 ratio be fully mixed back system capsule, washes capsule, drying, bottling after the assay was approved, vanning, product.
Claims (1)
1. astragalus and honey soft capsule, it is characterized in that the Daxing'an Mountainrange real estate Radix Astragali, the fruit of Chinese magnoliavine, propolis, melissa powder, royal jelly reasonable compatibility, utilize vacuum freeze drying, ultra-fine grinding, ultrasonic extraction and bioengineering enzymolysis technology, fully extract and the reservation nourishing healthy factor, realize that the trophic factors polymerization is living new, outstanding additive effect is made soft capsule dosage form and preparation method thereof.The Astragaloside IV positive in the product, the schizandrin A positive, general flavone content 〉=2%, protein 〉=3%, 10-hydroxyl-2-decylenic acid content 〉=0.2%.The preparation method of this kind astragalus and honey soft capsule is:
(1), the Radix Astragali and the fruit of Chinese magnoliavine are selected separately, impurity elimination, cleaned, carry out ultra-fine grinding after the vacuum drying, utilization ultrasonic extraction technology is extracted behind the functional component to such an extent that extract is standby;
(2), propolis is removed impurity, pulverize after freezing, adopt the ultrasonic extraction technology to extract behind the functional component to such an extent that extract is standby;
(3), the pollen weight 40% water freezing 24h in back that stirs is selected, pulverizes after the impurity elimination, added to the melissa powder, add immediately after the taking-up pollen weight 160% hot water stir dissolve, homogeneous, enzymolysis, behind the one-step palletizing the bee pollen peptide powder is standby;
(4), royal jelly is thawed, filter out impurity such as beeswax, utilization vacuum freeze drying, ultra-fine grinding technology are made behind the fine particle state freeze-dried powder standby;
(5), according to Astragalus Root P.E: Schisandra chinens P.E: propolis extract: bee pollen peptide powder: royal jelly freeze-dried powder: vegetable oil 3: 3: 1: 1: 1: 1 ratio is fully mixed back system capsule, washes capsule, and drying is bottled after the assay was approved, and vanning gets product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2009100718938A CN101869287B (en) | 2009-04-23 | 2009-04-23 | Astragalus and honey soft capsule and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102823792A (en) * | 2012-08-28 | 2012-12-19 | 安徽省王巢食品有限公司 | Soft propolis astragalus mongholicus capsule and preparation method thereof |
| CN103181930A (en) * | 2013-03-16 | 2013-07-03 | 西北大学 | Effective parts of schisandra bee pollen and application thereof in liver injury prevention |
| CN104906243A (en) * | 2015-05-25 | 2015-09-16 | 上海焦点生物技术有限公司 | Traditional Chinese medicine compound with liver protection function |
| CN105395677A (en) * | 2015-11-20 | 2016-03-16 | 武汉思维特食品有限公司 | Royal jelly, propolis and Chinese magnoliavine fruit capsule and preparation method thereof |
| CN107736596A (en) * | 2017-10-23 | 2018-02-27 | 佛山科学技术学院 | A kind of royal jelly capsule for improving memory function and preparation method thereof |
| CN108294269A (en) * | 2018-01-30 | 2018-07-20 | 叶水华 | A kind of strengthen immunity and health care capsule used for relieving physical fatigue production method |
| CN108938673A (en) * | 2018-08-22 | 2018-12-07 | 赵丽静 | A kind of drug and preparation method thereof for treating otitis media suppurative |
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| CN1430982A (en) * | 2003-01-13 | 2003-07-23 | 徐春华 | Capsule of astragalus and honey as well as its preparing technique |
| CN101152239A (en) * | 2006-09-27 | 2008-04-02 | 上海水产大学 | Technique of preparing drone pupa freeze-dried powder medicinal granules and capsule |
| CN101401821B (en) * | 2007-10-06 | 2011-10-05 | 徐春华 | Bee pollen peptide slice and preparation method thereof |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102823792A (en) * | 2012-08-28 | 2012-12-19 | 安徽省王巢食品有限公司 | Soft propolis astragalus mongholicus capsule and preparation method thereof |
| CN102823792B (en) * | 2012-08-28 | 2013-09-11 | 安徽省王巢食品有限公司 | Soft propolis astragalus mongholicus capsule and preparation method thereof |
| CN103181930A (en) * | 2013-03-16 | 2013-07-03 | 西北大学 | Effective parts of schisandra bee pollen and application thereof in liver injury prevention |
| CN103181930B (en) * | 2013-03-16 | 2016-04-13 | 西北大学 | Fructus Schisandrae Chinensis effective part of bee pollen form and the application in prevention hepar damnification thereof |
| CN104906243A (en) * | 2015-05-25 | 2015-09-16 | 上海焦点生物技术有限公司 | Traditional Chinese medicine compound with liver protection function |
| CN105395677A (en) * | 2015-11-20 | 2016-03-16 | 武汉思维特食品有限公司 | Royal jelly, propolis and Chinese magnoliavine fruit capsule and preparation method thereof |
| CN107736596A (en) * | 2017-10-23 | 2018-02-27 | 佛山科学技术学院 | A kind of royal jelly capsule for improving memory function and preparation method thereof |
| CN108294269A (en) * | 2018-01-30 | 2018-07-20 | 叶水华 | A kind of strengthen immunity and health care capsule used for relieving physical fatigue production method |
| CN108938673A (en) * | 2018-08-22 | 2018-12-07 | 赵丽静 | A kind of drug and preparation method thereof for treating otitis media suppurative |
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| CN101869287B (en) | 2013-03-20 |
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