CN103705631B - Gegenjiangtang capsules and preparation method - Google Patents

Abstract

A kind of Gegenjiangtang capsules and preparation method, it is made up of the raw material of following composition by weight: Radix Astragali 9-30 part, Radix Rehmanniae 10-30 part, Fructus Mori 15-30 part, Radix Scrophulariae 15-30 part, Radix Puerariae 15-30 part, Fructus Mume 12-25 part, Folium Mori 10-30 part; Mulberry powder is broken into fine powder and crosses mesh sieve, Radix Puerariae is added 65 ~ 75% appropriate ethanol, extract reflux extracting liquid; Add water the Radix Astragali, Radix Rehmanniae, Radix Scrophulariae, Fructus Mume, Folium Mori or add water dipped medical material face, decocts into decocting liquid; Concentrate and obtain clear paste, add ethanol and make alcohol content reach 55 ~ 65%, stir evenly, obtain alcohol and mix liquid; Reflux extracting liquid and alcohol are mixed liquid merge, reclaim ethanol, concentrate and obtain thick paste, add Mulberry powder, mixing, dry, pulverize, and after crossing 100 sieves, is packed in capsule shells, makes capsule.Its advantage is that long-term taking can not cause hypoglycemia complication, and do not find any toxic and side effects and untoward reaction, be better than insulin, opium protects the existing treatment hyperglycemia medicament such as new, this medicine has health care to immunomodulating simultaneously, extraordinary hypoglycemic medicine.

Description

Gegenjiangtang capsules and preparation method

Technical field

The present invention relates to and a kind ofly treat the medicine of diabetes, the Gegenjiangtang capsules of especially treating Qi and Yin deficiency diabetes mellitus and preparation method.

Background technology

Diabetes have become the commonly encountered diseases, the frequently-occurring disease that threaten human health.According to the 5th the IDF's Xi Tai district meeting held in Beijing a few days ago, the type Ⅱdiabetes mellitus that the whole world has been diagnosed has at present reached 1.3 hundred million people, and China is more than 40,000,000 people; Type Ⅱdiabetes mellitus will be popular in developing countries such as China, India 21 century.By 2025, global diabetics may break through 300,000,000, and China's diabetics sum, close to 100,000,000, becomes diabetics number second big country in the world.

Relevant expert thinks, plays important advantages, and the new Chinese medicine that screening has multiple blood sugar lowering mechanism is one of effective way for the treatment of and containment diabetes de-velopment.From current clinical used or be about to application hypoglycemic medicine, various Western medicine has certain limitation and untoward reaction, or even very serious untoward reaction, as caused hypoglycemia, lactic acidosis etc., and Chinese medicine preparation lack curative effect certainly, hypoglycemic medicine that clinician and patient take like a shot.Up to the present, also do not have a kind of medicine to cure diabetes, Western medicine also just can control blood glucose.But because Chinese medicine has the advantage of oneself, the progressively formation " returning " upsurge natural along with the world, Chinese medicine development prospect is good.Many single medicinal materials or compound preparation all show multiple blood sugar lowering mechanism, stimulate insulin β cells secrete insulin as many medicines have simultaneously, suppress the secretion of glucagon, increase the sensitivity of Insulin receptor INSR, suppress the intestinal absorption of glucose, improve fatty acid metabolism etc., first the medicine can curing diabetes probably obtains from Chinese medicine.

Some experts are by finding the research of Folium Mori: Folium Mori contain a kind of active substance---1-DNJ (DNJ) of natural suppression intestinal absorption glucose, and it can block the absorption of glucose in intestinal.By suppressing the synthesis that alpha-glucosidase in animal body is active, suppress sugar, the blood sugar level in body after diet can be reduced, reach the object of symptom management.

Summary of the invention

Object of the present invention is just to provide a kind of disease treating diabetes class, and solving the misery of patient, is mankind's health service Gegenjiangtang capsules and preparation method.

Solution of the present invention is such:

Gegenjiangtang capsules of the present invention is effective prescription for the treatment of Qi and Yin deficiency diabetes mellitus.Patient apparent for polydipsia, polyphagia, polyuria, weak, become thin, vulnerable, easily suffer from diseases caused by exogenous pathogenic factor, light red tongue is dark, the symptoms such as deep-thready pulse.

The seven flavor medicine of Gegenjiangtang capsules of the present invention proves hypoglycemic medicine by pharmacological research.Folium Mori join the Radix Astragali, Radix Rehmanniae blood sugar lowering urine, and the traditional Chinese medical science " legendary god of farming's draft " is just used as medicine a kind of Folium Mori.Modern age clinical proof, " Folium Mori " have wind and heat dispersing, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving, the effect such as nervous system regulation and lipid metabolism.The invigorating middle warmer of the Radix Astragali, QI invigorating, the cloudy fixing striae of liter and Radix Rehmanniae YIN nourishing, the effect of supporting essence of reinforcing the kidney can prevent precise and tiny the sewing of diet, make glucose in urine transfer feminine gender to.Pharmacological research proves: Folium Mori are at the rat diabetes that causes alloxan of decortication sterone, or the mice hyperglycemia that epinephrine, glucagon, AIS cause all has hypoglycemic activity.Astragalus polysaccharides can promote that human serum and hepatic protein upgrade, and is dual regulation, has no significant effect euglycemia carbohydrate metabolism, significantly can reduce the blood sugar level of human body after glucose load.Radix Rehmanniae energy Inhibition test hyperglycemia, also can make Rabbits ' Blood Sugar reduce; It may be one of its nourishing yin effect mechanism that Fructus Mori reduces silk erythrocyte membrane Na+-K+-ATP enzymatic activity, the dizziness that treatment diabetes cause, tinnitus, the disease such as thirsty clearly; Radix Scrophulariae, this product has inhibitory action to the pathogenic and non-pathogenic fungus of kind, has hypoglycemic activity to rabbit; Radix Puerariae decocting liquid is oral to rabbit, has and reduces blood glucose effect; Fructus Mume has potentiation to immunologic function.Above-mentioned is that applicant is according to the etiology and pathogenesis of diabetes, in conjunction with traditional Chinese medicine theory, medication experience among the people, on selected folk remedy and several years research of technique basis, from the research of medical science, pharmacology with summing up, select Radix Puerariae, Fructus Mori etc. seven taste Chinese crude drug adopt modern pharmaceutical engineering to develop successfully, there is 21st century bleeding edge new drug---Gegenjiangtang capsules.Show that the present invention has supplementing QI and nourishing YIN, promoting the production of body fluid to quench thirst.For diabetes caused by deficiency of both QI and YIN, disease is seen polydipsia, polyuria, is become thin, fatigue and lack of strength, and type ii diabetes is shown in above-mentioned disease person.More remarkable than other drug in diabetes basic area curative effect, tool is safe and reliable, without any side effects.The unique pharmacological effect of product of the present invention, will bring unprecedented Gospel for diabetics.

To be that a kind of chronic metabolic that caused by Different types of etiopathogenises is abnormal comprehensively demonstrate,prove diabetes, belongs to Chinese medicine and to quench one's thirst category, with excessive thirst taking fluids profusely, rapid digestion of food and polyorexia, frequency of micturition, emaciated physique etc. for feature.Take a broad view of various schools, for the primary disease cause of disease nothing more than diseases caused by exogenous pathogenic factor six climate exopathogens, obesity, diet sweet and refreshing cross contain, seven emotions are caused a disease, after serious disease, product that surfeit is supporing yang; Pathogenesis is thought due to lung, stomach, kidney internal organs dysfunction more, and cause that the deficiency of YIN is scorching, congestion internal resistance is for sick.Emphasize that the deficiency of YIN is this, scorching is mark, and gastric heat is insufficiency of the spleen is the most basic pathogenesis.Should by tonifying the spleen and stomach through whole treatment all the time, and blood circulation promoting and blood stasis dispelling, nourshing Yin and drynsessmoistening prescriptionly become opinion with the state of an illness.

The present invention be for treat deficiency of both QI and YIN diabetes and establish.With Radix Astragali slightly warm in nature in side, there is air making-up and spleen enlivening, the effect of nourishing blood of promoting the production of body fluid.Compatibility Radix Rehmanniae is cold in nature, and sweet-bitter flavor has resolving heat and reducing pathogenic fire, the effect of the removing heat from blood that promotes the production of body fluid.Be used for the treatment of hypertension, reduce blood glucose.Fructus Mori is cold in nature, and sweet in the mouth acid, has nourishing YIN and supplementing blood, the effect of moisturizing of promoting the production of body fluid.Radix Scrophulariae is cold in nature, sweet-bitter flavor, has yin nourishing, heat clearing away, removing heat from blood, falls hypoglycemic effect.Fructus Mume is put down, sour in the mouth, puckery, has the effect that deficiency-heat is quenched one's thirst.Radix Puerariae is put down, and sweet in the mouth is pungent, has the effect of promoting the production of body fluid to quench thirst.Be equipped with Folium Mori again and there is dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, the effect of liver heat removing and eyesight improving.All tastes share above, gather the merit of supplementing QI and nourishing YIN, promoting the production of body fluid to quench thirst altogether.For diabetes caused by deficiency of both QI and YIN, disease is seen polydipsia, polyuria, is become thin, fatigue and lack of strength, and type ii diabetes is shown in above-mentioned disease person.

Through studying for many years, find that Bombyxmori Linnaeus being equipped with Chinese medicine has unique curative effect to therapeutic type diabetes.We make full use of the medicine that this development of resources makes new advances, for diabetics provides a kind of selection newly.Prove through clinical research, Folium Mori have significant hypoglycemic activity to human body, are made into the Gegenjiangtang capsules be made up of Chinese medicine of the present invention, and patient takes reduction blood glucose value after 4 weeks can reach 20%, has remarkable result to treatment diabetes.

A kind of Gegenjiangtang capsules of the present invention, it is made up of the raw material of following composition by weight:

Radix Astragali 9-30 part Radix Rehmanniae 10-30 part Fructus Mori 15-30 part Radix Scrophulariae 15-30 part

Radix Puerariae 15-30 part Fructus Mume 12-25 part Folium Mori 10-30 part;

Mulberry powder is broken into fine powder and crosses mesh sieve, Radix Puerariae is added 65 ~ 75% appropriate ethanol, heating and refluxing extraction twice, each 2 ~ 3 hours, merge twice reflux extracting liquid; It is the water of 5 ~ 9 times or the dipped medical material face that adds water that the Radix Astragali, Radix Rehmanniae, Radix Scrophulariae, Fructus Mume, Folium Mori are added w/v, and decoct twice, 1.5 ~ 2.5 hours first times, second time 1 ~ 2 hour, merges twice decocting liquid; When being concentrated into 60 ~ 70 DEG C, relative density is the clear paste of 1.18 ~ 1.22, adds ethanol and makes alcohol content reach 55 ~ 65%, stir evenly, and leaves standstill 36 ~ 48 hours, obtains alcohol and mix liquid; Reflux extracting liquid and alcohol are mixed liquid merge, reclaim ethanol, when being concentrated into 60 ~ 70 DEG C, relative density is the thick paste of 1.28 ~ 1.32, adds Mulberry powder, and mixing, dry, pulverize, and after crossing 100 sieves, is packed in capsule shells, makes capsule.

Technical scheme also comprises more specifically: it is made up of the raw material of following composition by weight:

Radix Astragali 60g Radix Rehmanniae 55g Fructus Mori 45g Radix Scrophulariae 45g

Radix Puerariae 40g Fructus Mume 40g Folium Mori 45g;

Mulberry powder is broken into fine powder and crosses mesh sieve, Radix Puerariae is added 65 ~ 75% appropriate ethanol, heating and refluxing extraction twice, each 2 ~ 3 hours, merge twice reflux extracting liquid; It is the water of 5 ~ 7 times or the dipped medical material face that adds water that the Radix Astragali, Radix Rehmanniae, Radix Scrophulariae, Fructus Mume, Folium Mori are added w/v, and decoct twice, 1.5 ~ 2.5 hours first times, second time 1 ~ 2 hour, merges twice decocting liquid; When being concentrated into 60 ~ 70 DEG C, relative density is the clear paste of 1.18 ~ 1.22, adds ethanol and makes alcohol content reach 55 ~ 65%, stir evenly, and leaves standstill 36 ~ 48 hours, obtains alcohol and mix liquid; Reflux extracting liquid and alcohol are mixed liquid merge, reclaim ethanol, when being concentrated into 60 ~ 70 DEG C, relative density is the thick paste of 1.28 ~ 1.32, adds Mulberry powder, and mixing, dry, pulverize, and after crossing 100 sieves, is packed in capsule shells, makes capsule.

Further: it is made up of the raw material of following composition by weight:

Radix Astragali 55g Radix Rehmanniae 45g Fructus Mori 35g Radix Scrophulariae 35g

Radix Puerariae 40g Fructus Mume 40g Folium Mori 40g;

Mulberry powder is broken into fine powder and crosses mesh sieve, Radix Puerariae is added 65 ~ 75% appropriate ethanol, heating and refluxing extraction twice, each 2 ~ 3 hours, merge twice reflux extracting liquid; It is the water of 7 ~ 9 times or the dipped medical material face that adds water that the Radix Astragali, Radix Rehmanniae, Radix Scrophulariae, Fructus Mume, Folium Mori are added w/v, and decoct twice, 1.5 ~ 2.5 hours first times, second time 1 ~ 2 hour, merges twice decocting liquid; When being concentrated into 60 ~ 70 DEG C, relative density is the clear paste of 1.18 ~ 1.22, adds ethanol and makes alcohol content reach 55 ~ 65%, stir evenly, and leaves standstill 36 ~ 48 hours, obtains alcohol and mix liquid; Reflux extracting liquid and alcohol are mixed liquid merge, reclaim ethanol, when being concentrated into 60 ~ 70 DEG C, relative density is the thick paste of 1.28 ~ 1.32, adds Mulberry powder, and mixing, dry, pulverize, and after crossing 100 sieves, is packed in capsule shells, makes capsule.

Further: it is made up of the raw material of following composition by weight:

Radix Astragali 55g Radix Rehmanniae 45g Fructus Mori 35g Radix Scrophulariae 35g

Radix Puerariae 40g Fructus Mume 40g Folium Mori 40g;

Mulberry powder is broken into fine powder and crosses mesh sieve, Radix Puerariae is added 65 ~ 75% appropriate ethanol, heating and refluxing extraction twice, each 2 ~ 3 hours, merge twice reflux extracting liquid; It is the water of 6 ~ 8 times or the dipped medical material face that adds water that the Radix Astragali, Radix Rehmanniae, Radix Scrophulariae, Fructus Mume, Folium Mori are added w/v, and decoct twice, 1.5 ~ 2.5 hours first times, second time 1 ~ 2 hour, merges twice decocting liquid; When being concentrated into 60 ~ 70 DEG C, relative density is the clear paste of 1.18 ~ 1.22, adds ethanol and makes alcohol content reach 55 ~ 65%, stir evenly, and leaves standstill 36 ~ 48 hours, obtains alcohol and mix liquid; Reflux extracting liquid and alcohol are mixed liquid merge, reclaim ethanol, when being concentrated into 60 ~ 70 DEG C, relative density is the thick paste of 1.28 ~ 1.32, adds Mulberry powder, and mixing, dry, pulverize, and after crossing 100 sieves, is packed in capsule shells, makes capsule.

A preparation method for Gegenjiangtang capsules, comprises step:

(1), each raw material is got by the composition by weight of prescription raw material;

(2), get Fructus Mori, be ground into fine powder, cross 100 mesh sieves, for subsequent use;

(3), Radix Puerariae, add 65 ~ 75% ethanol that w/v is 6 ~ 8 times amount, heating and refluxing extraction twice, each 2 ~ 3 hours, merge twice reflux extracting liquid;

(4), to add w/v be the water of 5 ~ 9 times or the dipped medical material face that adds water for the Radix Astragali, Radix Rehmanniae, Radix Scrophulariae, Fructus Mume, Folium Mori, and decoct twice, 1.5 ~ 2.5 hours first times, second time 1 ~ 2 hour, merges twice decocting liquid; When being concentrated into 60 ~ 70 DEG C, relative density is the clear paste of 1.18 ~ 1.22, adds ethanol and makes alcohol content reach 55 ~ 65%, stir evenly, and leaves standstill 36 ~ 48 hours, obtains alcohol and mix liquid;

(5), the alcohol of the reflux extracting liquid of step (3) gained and step (4) gained is mixed liquid merge, reclaim ethanol, when being concentrated into 60 ~ 70 DEG C, relative density is the thick paste of 1.28 ~ 1.32, adds the Mulberry powder of step (1) gained, mixing, dry, pulverize, cross 100 sieves, semi-finished product, for subsequent use;

(6), the semi-finished product of step (5) are packed in capsule shells, make capsule.

Advantage of the present invention shows through clinical trial, and this medicine passes through to suppress alpha-glucosidase in animal body active, and suppress the synthesis of sugar, the blood sugar level after reduction diet in body, reaches the object of symptom management; To non-insulin-depending type (II type) diabetics, there is significant curative effect.Long-term taking can not cause hypoglycemia complication, and do not find any toxic and side effects and untoward reaction, be better than insulin, opium protects the existing treatment hyperglycemia medicament such as new, this medicine has health care to immunomodulating simultaneously, extraordinary hypoglycemic medicine, has the value of development.

Detailed description of the invention

Embodiment 1:

Formula: Radix Astragali 60g Radix Rehmanniae 55g Fructus Mori 45g Radix Scrophulariae 45g

Radix Puerariae 40g Fructus Mume 40g Folium Mori 45g

Preparation process:

Fructus Mori crosses 100 mesh sieves (particle diameter 0.15 ㎜) after pulverizing.Get Radix Puerariae and add 65 ~ 75% ethanol that w/v is 6 ~ 8 times amount, heating and refluxing extraction twice, each 2 ~ 3 hours, merge extracted twice liquid.It is the water of 5 ~ 7 times or the dipped medical material face that adds water that the Radix Astragali, Radix Rehmanniae, Radix Scrophulariae, Fructus Mume, Folium Mori gomi herbs add w/v, decoct twice, 1.5 ~ 2.5 hours first times, second time 1 ~ 2 hour, merges twice decocting liquid, is concentrated into the clear paste (60 ~ 70 DEG C) that relative density is 1.18 ~ 1.22, adding ethanol makes alcohol content reach 55 ~ 65%, stir evenly, leave standstill 36 ~ 48 hours, obtain alcohol and mix liquid; Merging reflux extracting liquid and alcohol mix liquid and reclaim ethanol, are concentrated into the thick paste (60 ~ 70 DEG C) that relative density is 1.28-1.32, add silkworm powder, and mixing, dry, pulverize, and cross 100 mesh sieves (particle diameter 0.15 ㎜), obtain semi-finished product.Semi-finished product are packed in capsule shells, 0.35 gram every, obtain 200 capsules finished products.

Embodiment 2:

Formula: Radix Astragali 55g Radix Rehmanniae 45g Fructus Mori 35g Radix Scrophulariae 35g

Radix Puerariae 40g Fructus Mume 40g Folium Mori 40g

Preparation process:

Be that except the decocting in water of 7 ~ 9 times extracted after 1.5 ~ 2.5 hours, all the other are with embodiment 1 except the gomi herbs such as the Radix Astragali add w/v.

Embodiment 3:

Formula: Radix Astragali 55g Radix Rehmanniae 50g Fructus Mori 45g Radix Scrophulariae 45g

Radix Puerariae 35g Fructus Mume 35g Folium Mori 45g

Preparation process:

Be that except the decocting in water of 6 ~ 8 times extracted after 1.5 ~ 2.5 hours, all the other are with embodiment 1 except the gomi herbs such as the Radix Astragali add w/v.

Introduce with capsule for treating effect model case made by the present invention:

Example one:

Wu, women, 48 years old, JIUYUE in 2008 was gone to a doctor on the 5th, and patient is over nearly 6 months, polydipsia, polyuria, polyphagia, the bodily form is become thin, the soreness of waist, and lower limb is soft, dry pharynx dryness of the tongue, feverish sensation in the palms and soles, time have weak breathing hard, aversion to cold and cold limbs, deep red tongue, yellow fur is done, and arteries and veins counts along string, tcm diagnosis: diabetes, deficiency of both QI and YIN disease.Look into: glucose in urine (+++), control nourishing YIN and clearing away heat, promoting the production of body fluid to quench thirst, supplementing QI and nourishing YIN, namely gives Gegenjiangtang capsules of the present invention, each 4, warm water delivery service, every day three times, after taking one month, glucose in urine is reduced to (++), all diseases disappear substantially, and continue clothes to 2 months, all diseases disappear, efficacy evaluation: diabetes is not sent out always, glucose in urine is all normal on inspection.

Example two:

Korea Spro, man, 44 years old.Patient in December, 2008 because of tired, mood is smooth and feel weak all over the body, then there is thirsty, frequent micturition, polyphagia, become thin, and increase the weight of gradually.Through examination in hospital, blood glucose 422mg%, glucose in urine (++++), ketoboidies strong positive, enters Concord Hospital and rescues.After insulin injection, ketoboidies is turned out cloudy, and blood glucose is reduced to 237mg%, and glucose in urine is still for (++++) symptom has no obvious improvement.Insulin injection increases to 48 units by 36 units, still without significant change, leaves hospital subsequently.In in February, 2009 hospital admission, the conscious whole body of patient was weak at that time, and soreness of the waist and knees is thirsty, frequent micturition, polyphagia, spontaneous perspiration, deep,thready and forceless pulse, crimson tongue with a little fur.For deficiency of both QI and YIN, deficiency of the liver and kindey, namely give Gegenjiangtang capsules of the present invention, each 4, warm water delivery service, every day three times.Symptom disappears substantially after two months, check blood glucose 107mg%, 154mg% after the meal, and glucose in urine is negative, continues and takes the drug withdrawal after 3 months of this medicine, recovers normal, has no recurrence.

Example three:

Song, man, 52 years old, cadre, was paid a home visit on May 18th, 2009.Patient suffered from diabetes before 2 years, and once seek medical advice effect of taking medicine of many places was undesirable.Finding when examining: dizzy, vexed, irritability, bitter taste, dry pharynx, oral erosion, constipated during stool, time and suffer from diarrhoea, impotence and seminal emission, dream at night is peaceful, and little furuncle and phyma has appearred in skin, and symptom more than three is not obvious, and body constitution is partially fat, and normal sense is weak, can not adhere to normal work.Stringy and thready pulse, body of the tongue is partially red, and purple lip is blue or green, and dark complexion is not flourish.Have urine examined sugar +++, blood glucose: 10.46mmol/L.Scan its because of, thorny because working in 2008, brain overwork, feelings will damage psychological unbalance and bringing out.Tcm diagnosis is depressed emotion, stagnation of liver-QI with deficiency of the spleen, and deficiency of vital energy damage of kidney-YIN makes so.Namely giving Gegenjiangtang capsules of the present invention, each 4, warm water delivery service, every day three times, through treating three months, being aided with rehabilitation education simultaneously, blood glucose, glucose in urine recover normal, and all disease knowing are moved back, and it is normal to follow up a case by regular visits to Working Life so far.

Claims (5)

1. a Gegenjiangtang capsules, is characterized in that: it is made up of the raw material of following composition by weight:

Radix Astragali 9-30 part Radix Rehmanniae 10-30 part Fructus Mori 15-30 part Radix Scrophulariae 15-30 part

Radix Puerariae 15-30 part Fructus Mume 12-25 part Folium Mori 10-30 part;

Mulberry powder is broken into fine powder and crosses mesh sieve, Radix Puerariae is added 65 ~ 75% appropriate ethanol, heating and refluxing extraction twice, each 2 ~ 3 hours, merge twice reflux extracting liquid; It is the water of 5 ~ 9 times or the dipped medical material face that adds water that the Radix Astragali, Radix Rehmanniae, Radix Scrophulariae, Fructus Mume, Folium Mori are added w/v, and decoct twice, 1.5 ~ 2.5 hours first times, second time 1 ~ 2 hour, merges twice decocting liquid; When being concentrated into 60 ~ 70 DEG C, relative density is the clear paste of 1.18 ~ 1.22, adds ethanol and makes alcohol content reach 55 ~ 65%, stir evenly, and leaves standstill 36 ~ 48 hours, obtains alcohol and mix liquid; Reflux extracting liquid and alcohol are mixed liquid merge, reclaim ethanol, when being concentrated into 60 ~ 70 DEG C, relative density is the thick paste of 1.28 ~ 1.32, adds Mulberry powder, and mixing, dry, pulverize, and after crossing 100 sieves, is packed in capsule shells, makes capsule.

2. Gegenjiangtang capsules according to claim 1, is characterized in that: it is made up of the raw material of following composition by weight:

Radix Astragali 60g Radix Rehmanniae 55g Fructus Mori 45g Radix Scrophulariae 45g

Radix Puerariae 40g Fructus Mume 40g Folium Mori 45g;

Mulberry powder is broken into fine powder and crosses mesh sieve, Radix Puerariae is added 65 ~ 75% appropriate ethanol, heating and refluxing extraction twice, each 2 ~ 3 hours, merge twice reflux extracting liquid; It is the water of 5 ~ 7 times or the dipped medical material face that adds water that the Radix Astragali, Radix Rehmanniae, Radix Scrophulariae, Fructus Mume, Folium Mori are added w/v, and decoct twice, 1.5 ~ 2.5 hours first times, second time 1 ~ 2 hour, merges twice decocting liquid; When being concentrated into 60 ~ 70 DEG C, relative density is the clear paste of 1.18 ~ 1.22, adds ethanol and makes alcohol content reach 55 ~ 65%, stir evenly, and leaves standstill 36 ~ 48 hours, obtains alcohol and mix liquid; Reflux extracting liquid and alcohol are mixed liquid merge, reclaim ethanol, when being concentrated into 60 ~ 70 DEG C, relative density is the thick paste of 1.28 ~ 1.32, adds Mulberry powder, and mixing, dry, pulverize, and after crossing 100 sieves, is packed in capsule shells, makes capsule.

3. Gegenjiangtang capsules according to claim 1, is characterized in that: it is made up of the raw material of following composition by weight:

Radix Astragali 55g Radix Rehmanniae 45g Fructus Mori 35g Radix Scrophulariae 35g

Radix Puerariae 40g Fructus Mume 40g Folium Mori 40g;

Mulberry powder is broken into fine powder and crosses mesh sieve, Radix Puerariae is added 65 ~ 75% appropriate ethanol, heating and refluxing extraction twice, each 2 ~ 3 hours, merge twice reflux extracting liquid; It is the water of 7 ~ 9 times or the dipped medical material face that adds water that the Radix Astragali, Radix Rehmanniae, Radix Scrophulariae, Fructus Mume, Folium Mori are added w/v, and decoct twice, 1.5 ~ 2.5 hours first times, second time 1 ~ 2 hour, merges twice decocting liquid; When being concentrated into 60 ~ 70 DEG C, relative density is the clear paste of 1.18 ~ 1.22, adds ethanol and makes alcohol content reach 55 ~ 65%, stir evenly, and leaves standstill 36 ~ 48 hours, obtains alcohol and mix liquid; Reflux extracting liquid and alcohol are mixed liquid merge, reclaim ethanol, when being concentrated into 60 ~ 70 DEG C, relative density is the thick paste of 1.28 ~ 1.32, adds Mulberry powder, and mixing, dry, pulverize, and after crossing 100 sieves, is packed in capsule shells, makes capsule.

4. Gegenjiangtang capsules according to claim 1, is characterized in that: it is made up of the raw material of following composition by weight:

Radix Astragali 55g Radix Rehmanniae 45g Fructus Mori 35g Radix Scrophulariae 35g

Radix Puerariae 40g Fructus Mume 40g Folium Mori 40g;

Mulberry powder is broken into fine powder and crosses mesh sieve, Radix Puerariae is added 65 ~ 75% appropriate ethanol, heating and refluxing extraction twice, each 2 ~ 3 hours, merge twice reflux extracting liquid; It is the water of 6 ~ 8 times or the dipped medical material face that adds water that the Radix Astragali, Radix Rehmanniae, Radix Scrophulariae, Fructus Mume, Folium Mori are added w/v, and decoct twice, 1.5 ~ 2.5 hours first times, second time 1 ~ 2 hour, merges twice decocting liquid; When being concentrated into 60 ~ 70 DEG C, relative density is the clear paste of 1.18 ~ 1.22, adds ethanol and makes alcohol content reach 55 ~ 65%, stir evenly, and leaves standstill 36 ~ 48 hours, obtains alcohol and mix liquid; Reflux extracting liquid and alcohol are mixed liquid merge, reclaim ethanol, when being concentrated into 60 ~ 70 DEG C, relative density is the thick paste of 1.28 ~ 1.32, adds Mulberry powder, and mixing, dry, pulverize, and after crossing 100 sieves, is packed in capsule shells, makes capsule.

5. the preparation method of Gegenjiangtang capsules according to claim 1, is characterized in that: comprise step:

(1), each raw material is got by the composition by weight of prescription raw material;

(2), get Fructus Mori, be ground into fine powder, cross 100 mesh sieves, for subsequent use;

(3), Radix Puerariae, add 65 ~ 75% ethanol that w/v is 6 ~ 8 times amount, heating and refluxing extraction twice, each 2 ~ 3 hours, merge twice reflux extracting liquid;

(4), to add w/v be the water of 5 ~ 9 times or the dipped medical material face that adds water for the Radix Astragali, Radix Rehmanniae, Radix Scrophulariae, Fructus Mume, Folium Mori, and decoct twice, 1.5 ~ 2.5 hours first times, second time 1 ~ 2 hour, merges twice decocting liquid; When being concentrated into 60 ~ 70 DEG C, relative density is the clear paste of 1.18 ~ 1.22, adds ethanol and makes alcohol content reach 55 ~ 65%, stir evenly, and leaves standstill 36 ~ 48 hours, obtains alcohol and mix liquid;

(5), the alcohol of the reflux extracting liquid of step (3) gained and step (4) gained is mixed liquid merge, reclaim ethanol, when being concentrated into 60 ~ 70 DEG C, relative density is the thick paste of 1.28 ~ 1.32, adds the Mulberry powder of step (1) gained, mixing, dry, pulverize, cross 100 sieves, semi-finished product, for subsequent use;

(6), the semi-finished product of step (5) are packed in capsule shells, make capsule.