CN102000278B

CN102000278B - Traditional Chinese medicine for treating amblyopia eye diseases

Info

Publication number: CN102000278B
Application number: CN2010105527639A
Authority: CN
Inventors: 李宗智
Original assignee: Individual
Current assignee: Individual
Priority date: 2010-11-22
Filing date: 2010-11-22
Publication date: 2012-05-23
Anticipated expiration: 2030-11-22
Also published as: CN102000278A

Abstract

The invention discloses a traditional Chinese medicine for treating amblyopia eye diseases and relates to a preparation prepared from the traditional Chinese medicines as raw materials. The traditional Chinese medicine is prepared from semen cassiae, radix paeoniae alba, salvia miltiorrhiza, medlar, tuckahoe, dendrobe, kudzuvine root, tuber of dwarf lilyturf, tribulus terrestris, adenophora tetraphylla, yam, forsythia core, motherwort fruit, lophatherum gracile, antelope horn powder, glabrousleaf pittosporum seed and fructus psoraleae. The clinical use result of the traditional Chinese medicine shows that the prescription has the functions of enhancing the capability of supplying blood to caridiac muscle, promoting the blood circulation and improving the development process of eye parts of patients and promoting the repair of optic nerve and retina cells as well as the efficacies of nourishing the kidney, nourishing the liver and improving acuity of vision; the prescription can be used for treating amblyopia, hyperopia, yellow spot and other diseases caused by various reasons; and the traditional Chinese medicine has unique formula and curative effect, especially has remarkable effects for infants and juvenile patients and can ensure that the symptoms of the patients are eliminated and the visions of the patients are recovered.

Description

A kind of Chinese medicine of treating the amblyopia ophthalmic

Technical field

The present invention relates to pharmaceutical composition, in particular to the medicine that with the Chinese herbal medicine is the treatment amblyopia ophthalmic of preparation of raw material.

Background technology

Amblyopia is that the common ophthalmology of people takes a disease.The amblyopia disease has the multiple origin cause of formation, for example because the bad amblyopia that causes of infant development, with an eye mode bad amblyopia that causes, because the amblyopia that heredity causes, because the old amblyopia that causes, because drug-induced amblyopia, because excessive amblyopia that causes of tobacco and wine or the like.The amblyopia patient has the blurring of vision symptom usually; The patient that other ophthalmics are arranged also has that order is dark, blurred vision, conjunctival congestion, many tear, symptom such as hide from view.

China has accumulated rich experience over thousands of year aspect the treatment amblyopia takes a disease.In recent years; Had many treatment ophthalmics the Chinese medicine preparation application patent of invention, for example No. 91103283.5, one Chinese patent application " preparation of amblyopia ball and take method ", No. 97107788.6 " a kind of prescription and method for preparing of preventing and treating cataract Chinese medicine ", 98121617.x number " Chinese medicine pill that treating catarct is used and production method thereof ", No. 01120241.6 " a kind of Chinese medicine preparation and manufacture method of treating disease of eye " application part etc.; Also have some patent applications that vision is kept healthy, like No. 96120157.6 " a kind of health beverage " and No. 96120158.4 " a kind of health tea ".The Chinese medicine preparation and the health product of above-mentioned ophthalmics such as all treatment amblyopias have nothing in common with each other, and therapeutic effect also is not quite similar.In medical practice, in general, the Chinese traditional treatment amblyopia is effective, be free from side effects basically.The inventor also once had " a kind of Chinese medicine preparation of treating the amblyopia ophthalmic and preparation method thereof " ZL200410040983.8 number; The Chinese medicine preparation that proposes has certain therapeutic effect to the amblyopia patient; Belong to first generation product; But this patented technology need be improved, and could when the treatment amblyopia patient, reach better effect.

Summary of the invention

The object of the invention just is to provide a kind of Chinese medicine of treating the amblyopia ophthalmic, makes the patient can be in shorter time, and the vision that is improved obtains better therapeutic effect.

Solution of the present invention is based on the research of inventor at first generation product clinical treatment, examines the pluses and minuses of its original prescription closely, the second filial generation Chinese medicine preparation that develops.

The component and the consumption of the Chinese medicine preparation of the treatment amblyopia ophthalmic that the inventor provides are following:

60～120 parts of 60～120 parts of Radix Salviae Miltiorrhizaes of 80～200 parts of Radix Paeoniae Alba of Semen Cassiae

80～200 parts of 80～200 parts of Herba Dendrobiis of 80～200 parts of Poria of Fructus Lycii

60～120 parts of 60～120 portions of Fructus Tribulis of 80～200 parts of Radix Puerariaes of Radix Ophiopogonis

60～120 parts of 80～200 parts of golden bell cores of 80～200 portions of Rhizoma Dioscoreaes of Radix Adenophorae

5～20 parts of 40～100 parts of Cornu Saigae Tataricae powders of 60～120 portions of Herba Lophatheris of Fructus Leonuri

60～120 parts of wide 60～120 parts of Fructus Psoraleaes of Semen Pittospori Glabrati

In the above-mentioned Chinese medicine, Semen Cassiae (Cassia tora), bitter but sweet flavor, cool in nature, the effect that liver heat removing is arranged, makes eye bright can be controlled wind heat acute conjunctivitis, optic atrohic blindness, nyctalopia etc. take a disease (see the new medical college in Jiangsu compile " Chinese medicine voluminous dictionary " P949); Radix Paeoniae Alba (Paeonia lactiflora), bitter in the mouth acid, cool in nature, have nourish blood, the effect of easing the affected liver, can control diseases (seeing " Chinese medicine voluminous dictionary " P706) such as conjunctival congestion; Radix Salviae Miltiorrhizae (Salvia miltiorrhiza), bitter in the mouth, slightly warm in nature has the effect of promoting blood circulation and stopping pain, can control acute conjunctivitis (seeing " Chinese medicine voluminous dictionary " P480); Fructus Lycii (Lycium chinense), sweet in the mouth, property is flat, can nourishing kidney, lung moistening, tonifying liver, make eye bright, can control dizzy, the many tears of blurred vision (seeing " Chinese medicine voluminous dictionary " P1518); Poria (Poria cocos), slightly sweet flavor, property is flat, and the effect (seeing " Chinese medicine voluminous dictionary " P1596) of eliminating dampness and diuresis, happy Fructus Alpiniae Oxyphyllae is arranged; Herba Dendrobii (Dendrobium nobile or Dendrobium officinale), the little one-tenth of slightly sweet flavor, cold in nature, the ability clearing away heat and nourishing YIN can be controlled the moon and hinder order dark (seeing " Chinese medicine voluminous dictionary " P586); Radix Puerariae (Pueraria lobata), sweet in the mouth is hot, and property is flat, ability yang invigorating expelling pathogenic factors from muscles, but retinopathy (seeing " Chinese medicine voluminous dictionary " P2307); Radix Ophiopogonis (Ophiopogon japonicus), sweet and slightly bitter taste, property is flat, but nourishing YIN and moistening the lung, the liver benefiting that clears away heart-fire (seeing " Chinese medicine voluminous dictionary " P1024); Fructus Tribuli (Tribulus terrestris), acrid in the mouth is bitter, and warm in nature, the wind that can loose makes eye bright, and controls the swollen nebula (seeing " Chinese medicine voluminous dictionary " P1274) of conjunctival congestion; Radix Adenophorae (Ophiopogon japonicus) has another name called the bubble ginseng, and sweet and slightly bitter taste is cool in nature, but nourishing YIN and clearing away lung-heat (seeing " Chinese medicine voluminous dictionary " P1560); Rhizoma Dioscoreae (Dioscorea opposita) has another name called Rhizoma Dioscoreae, sweet in the mouth, and property is flat, but normal hearing and eyesight (seeing " Chinese medicine voluminous dictionary " P166) is obeyed in spleen invigorating for a long time; Golden bell core (Forsythia suspensa), i.e. Fructus Forsythiae, bitter in the mouth, cool in nature, but heat-clearing and toxic substances removing (seeing " Chinese medicine voluminous dictionary " P1111); Fructus Leonuri (Leonurus heterophyllus), i.e. FRUCTUS LEONURI, bitter but sweet flavor is hot, and is cool in nature, but wind and heat dispersing is controlled conjunctival congestion and swelling pain, nebula film (seeing " Chinese medicine voluminous dictionary " P1609); Herba Lophatheri (Lophatherum gracile), slightly sweet flavor, cold in nature, but clearing away heart-fire, heat clearing away and restlessness relieving (seeing " Chinese medicine voluminous dictionary " P2253); Cornu Saigae Tataricae powder is the angle of sahilite (Saiga tatarica), distinguishes the flavor of, and is cold in nature, but suppressing the hyperactive liver to relieve the wind syndrome, heat-clearing and toxic substances removing is controlled conjunctival congestion, nebula film (seeing " Chinese medicine voluminous dictionary " P2256); Wide Semen Pittospori Glabrati, promptly Semen Pittospori Glabrati is the seed of Pittosporaceae plant Pittosporum glabratum Lindl (Pittosporum glabratum), bitter and puckery flavor, property is flat, ability heat clearing away, promoting the production of body fluid to quench thirst (seeing " Chinese medicine voluminous dictionary " P184); Fructus Psoraleae is the fruit of legumes psoraleae (Psoralea corylifolia), and acrid in the mouth is warm in nature, ability reinforcing the kidney and supporting YANG (seeing " Chinese medicine voluminous dictionary " P1177); Above-mentioned medical material should meet " the regulation in one one of the Chinese pharmacopoeia nineteen ninety-five version under each medical material item.

Contrast first generation medicine (ZL200410040983.8 number) and second filial generation medicine can be found out, two generations most medical materials of filling a prescription be identical, but second filial generation prescription has increased wide Semen Pittospori Glabrati and Fructus Psoraleae without Bombyx Batryticatus.This is that its congenital natural endowment is not enough because the inventor finds many patients' amblyopia to be in medical practice gradually, and dysplasia or hypoevolutism cause, if use the treatment by Chinese herbs of first generation prescription, effect is difficult to satisfactory.For this reason, the inventor adds wide Semen Pittospori Glabrati in prescription, can increase patient's blood supply of cardiac muscle ability, promotes its blood circulation; Add Fructus Psoraleae simultaneously, improve patient's eye developmental process,, finally reach the rapid effect of improving vision to solve the problem of its congenital defect.

The preparation method of Chinese medicine of treatment amblyopia ophthalmic of the present invention is to be equipped with medicine by the Chinese crude drug of respectively distinguishing the flavor of in the prescription, and wherein, Rhizoma Dioscoreae and Poria are through cleaning, cure, be ground into fine powder, and be subsequent use; Cornu Saigae Tataricae is worn into powder in advance and is ground into fine powder, and it is subsequent use to cross No. 5 sieves; Again the medicinal clear water of 14 flavors such as Semen Cassiae, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Fructus Lycii, Herba Dendrobii, Radix Puerariae, Radix Ophiopogonis, Fructus Tribuli, Radix Adenophorae, golden bell core, Fructus Leonuri, Herba Lophatheri, wide Semen Pittospori Glabrati, Fructus Psoraleae are decocted; Extract decoction liquor; Carry out altogether 3 times, decocted 1 hour at every turn; Then the decoction liquor of extracting is filtered, get its filtrating steaming and decocting and concentrate and process extractum, add subsequent use medicated powder and Cornu Saigae Tataricae powder again, mixing; Dry with conventional method, pulverize, sieve, require the medicated powder fineness usually below 1mm, after the assay was approved, can carry out dosage form processing.Usually incapsulate, process the capsule product.Product should meet " requirement in one one of the Chinese pharmacopoeia nineteen ninety-five version, product index is following: it is 1.5g that every capsules contains former dose, and content uniformity is at 0.43g ± 10.0%; Moisture must not surpass 9.0%, and product disintegration is 30 minutes.

The Chinese medicine of treatment amblyopia ophthalmic of the present invention, method that also can be through routine or process powder or add compressed with adhesive to become tablet or process pill or add implant and process electuary etc. and process product by agitation procedure.

The usage of capsule of the present invention is oral, warm water delivery service, every day 3 times, each 2～3.

The Chinese medicine of treatment amblyopia ophthalmic of the present invention is clinical use result show, this prescription has the blood supply of cardiac muscle ability that increases the patient, promotes its blood circulation, improves patient's eye developmental process; The effect that also have nourishing kidney, nourishing the liver, makes eye bright; Can promote optic nerve, retina cell reparation, be used to treat amblyopia, hypermetropia and the maculopathy etc. that a variety of causes causes and take a disease that prescription is unique; Curative effect is also unique; Especially to infant and juvenile patient, evident in efficacy, can make the patient eliminate symptom, recover vision.

The inventor uses the medicine of second filial generation prescription successfully to cure many patients, and wherein more typical case has: the boy patient Huang Zihao of Shachong N. Road, Guiyang City, Guizhou Province is lived in (1), the time 8 months in addition 5 years old year; Suffer from eyes amblyopia disease in November, 2003, the images of left and right eyes vision is 0.25/0.33, takes the second filial generation Drug therapy that the present invention processes in 2003; The state of an illness progressively takes a turn for the better; Vision begins to improve after medication January, and vision reached normally basically in 2004, and amblyopia is fully recovered.The phone 0851-5772966 of this patient family.(2) live in the girl Chen Yuhan of Qingzhen City, Guizhou Province industrial and commercial bank dormitory, the time 6 years old year, the images of left and right eyes vision was respectively 0.8/0.66 and 0.6/1.0 because of suffering from eyes amblyopia disease in 2002, through taking medicine that the present invention processes after 14 months, binocular vision reaches 1.0.This patient's parent telephone 13595053950.(3) live in slope nine rows' of the big battalion in Guiyang girl Wang Maqiong, the time 12 years old year, found the left eye amblyopia in 2003; Vision is 0.25/0.5; Rise and take the capsule for treating that prescription of the present invention is processed in October, 2003, and the state of an illness progressively takes a turn for the better, and vision begins to improve after 1 week of medication; In January, 2004, left vision reached 0.8/1.5, the basic healing.The phone 0851-6750771 of this patient family.

The specific embodiment

Embodiment gets Rhizoma Dioscoreae 116g and Poria 116g through cleaning, cure, be ground into fine powder, and is subsequent use; Cornu Saigae Tataricae is worn into powder in advance and is ground into fine powder, and it is subsequent use to cross No. 5 sieves; Depend on that the more medicinal clear water of 14 flavors such as pine torch 116g, Radix Paeoniae Alba 93g, Radix Salviae Miltiorrhizae 93g, Fructus Lycii 116g, Herba Dendrobii 116g, Radix Puerariae 93g, Radix Ophiopogonis 116g, Fructus Tribuli 93g, Radix Adenophorae 116g, golden bell core 93g, Fructus Leonuri 93g, Herba Lophatheri 70g, wide Semen Pittospori Glabrati 93g, Fructus Psoraleae 93g decoct; Extract decoction liquor; Carry out altogether 3 times, decocted 1 hour at every turn; Then the decoction liquor of extracting is filtered, get its filtrating steaming and decocting and concentrate and process extractum, add subsequent use medicated powder 232g and Cornu Saigae Tataricae powder 8g again, mixing; Dry with conventional method, pulverize, sieve, the medicated powder fineness reaches below the 1mm, after the assay was approved, can incapsulate, it is 1.5g that every capsules contains former dose, processes the capsule product.When the patient takes, every day 3 times, each 2～3.

Claims

1. Chinese medicine of treating the amblyopia ophthalmic; Contain Semen Cassiae, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Fructus Lycii, Poria, Herba Dendrobii, Radix Puerariae, Radix Ophiopogonis, Fructus Tribuli, Radix Adenophorae, Rhizoma Dioscoreae, golden bell core, Fructus Leonuri, Herba Lophatheri, Cornu Saigae Tataricae powder; It is characterized in that this Chinese medicine also contains wide Semen Pittospori Glabrati and Fructus Psoraleae, the quality consumption of the component of this Chinese medicine preparation is following:

2. according to the Chinese medicine of the said treatment amblyopia of claim 1 ophthalmic, it is characterized in that this preparation method of Chinese medicine is: be equipped with medicine by prescription, wherein, Rhizoma Dioscoreae and Poria are through cleaning, cure, be ground into fine powder, and be subsequent use; Cornu Saigae Tataricae is worn into powder in advance and is ground into fine powder, and it is subsequent use to cross No. 5 sieves; Again the medicinal clear water of 14 flavors such as Semen Cassiae, Radix Paeoniae Alba, Radix Salviae Miltiorrhizae, Fructus Lycii, Herba Dendrobii, Radix Puerariae, Radix Ophiopogonis, Fructus Tribuli, Radix Adenophorae, golden bell core, Fructus Leonuri, Herba Lophatheri, wide Semen Pittospori Glabrati, Fructus Psoraleae are decocted; Extract decoction liquor; Carry out altogether 3 times, decocted 1 hour at every turn; Then the decoction liquor of extracting is filtered, get its filtrating steaming and decocting and concentrate and process extractum, add subsequent use medicated powder and Cornu Saigae Tataricae powder again, mixing; Dry with conventional method, pulverize, sieve, the medicated powder fineness promptly gets below 1mm.

3. according to the Chinese medicine of the said treatment amblyopia of claim 2 ophthalmic; It is characterized in that this Chinese medicine can incapsulate processes capsule, method that can also be through routine or process powder or add compressed with adhesive to become tablet or process pill or add implant and process electuary and process product by agitation procedure.