CN101485857B - Chinese medicine for tonifying kidney, invigorating heart and spleen, and strengthening function of human body and preparation method thereof - Google Patents
Chinese medicine for tonifying kidney, invigorating heart and spleen, and strengthening function of human body and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for tonifying kidney, strengthening heart and spleen, and enhancing function of human body, and a preparation method thereof. The preparation method comprises the following steps: adding water into ten gouts of traditional Chinese medicine comprising prepared rhizome of rehmannia, angelica, sauted white paeony root, asparagus, dwarf lilyturf turber, sauted Atractylis ovata, desertliving cistanche, tuckahoe with pine, sauted spina date seed and honey-soaked milkwort, then decocting the mixture thrice, mixing the thrice decoction, condensing filtered decoction into extract, adding red ginseng, dog kidney, rabbit brain, amber, natural indigo, sharpleaf galangal fruit and grassleaf sweelflag rhizome into the extract, crushing and sieving the components respectively, then evenly mixing the fine powder, adding proper amount of starch into the fine powder to prepare granules, and filling the granules into hollow capsules to obtain the traditional Chinese medicine capsule. The traditional Chinese medicine not only has good curative effect on kidney essence deficiency and heart-spleen deficiency, and has the efficacies of replenishing qi to invigorate the spleen, enriching blood to nourish the heart, nourishing the kidney and replenishing essence, but also has the advantages of short treatment course by oral administration, quick effect, little toxic and side effects, and convenience for carrying, and simultaneously has the advantages of rich raw material sources, simple preparation method and low cost.
Description
Technical field
The present invention relates to Chinese medicine of a kind of the kidney invigorating, strong heart spleen, enhances human body function and preparation method thereof.
Background technology
Deficiency of kidney-essence and deficiency of both the heart and spleen disease are the men, and middle-aging male commonly encountered diseases especially, and have with the age and increase the trend that rises also gets more and more because of diseases such as the middle aged women's severe palpitation due to the deficiency of both the heart and spleen disease, insomnia and dreamful sleep, spiritlessness and weakness simultaneously.Chinese medicine thinks that the generation of primary disease is relevant with the functional disorder of internal organs such as the heart, liver,spleen,kidney, and is especially close with the relation of kidney.Because excessive thinking, intemperate sexual intercourse, deficiency of kidney-essence, dampness-heat in the liver and gallbladder etc. all can cause the QI and blood meridian discord, penis loses and supports, but see with deficiency syndrome more.
The method of treating deficiency of kidney-essence and deficiency of both the heart and spleen disease clinically is various; In the majority with Drug therapy, its Chinese medicine and western medicine produce effects is fast, but side effect is big; Be prone to form drug dependence; All can play untoward reaction like some chemical classes medicine sildenafil citrates etc., even obvious pathological change occur, the infringement human organ because of improper use or abuse.Simultaneously, existing kidney invigorating and YANG supporting class Chinese medicine is also more, but because of lacking effective the kidney invigorating and essence nourishing medicine or illegally having added the chemical medicine material, quality is very different, and uncertain therapeutic efficacy is cut, and the life-time service hazardness is big, more can not treating both the principal and secondary aspects of a disease.
Summary of the invention
The purpose of this invention is to provide a kind ofly not only has good efficacy to deficiency of kidney-essence and deficiency of both the heart and spleen disease; Effect with replenishing QI to invigorate the spleen, replenishing blood for nourishing heart, nourishing kidney replenishing essence; And oral administration, Chinese medicine of short treating period, the kidney invigorating that produce effects is fast, toxic and side effects is little, easy to carry, strong heart spleen, enhances human body function and preparation method thereof.
Technical scheme of the present invention:
Chinese medicine of the present invention is processed (consumption is a weight portion) by following component
Radix Rehmanniae Preparata 70.6～95.5 Radix Angelicae Sinensis 28.1～38.0
Radix Paeoniae Alba (parched) 21.3～28.8 Radix Asparagis 21.3～28.8
Radix Ophiopogonis 21.3～28.8 Radix Ginseng Rubra 14.5～19.6
Rhizoma Atractylodis Macrocephalae (parched) 21.3～28.8 Testis et Pentis Canis 57.0～77.1
Herba Cistanches 28.1～38.0 Fructus Alpiniae Oxyphyllae 21.3～28.8
Medulla Leporis seu Oryctolagi 8.5～11.5 Poria cum Radix Pinis 42.5～57.5
Semen Ziziphi Spinosae (parched) 28.1～38.0 processed with honey Radix Polygalaes 14.5～19.6
Succinum 6.8～9.2 Rhizoma Acori Graminei 14.5～19.6
Indigo Naturalis 6.8～9.2 starch are an amount of
Water is an amount of.
The production method of above-mentioned each component being processed Chinese medicine of the present invention is:
(1) each raw material of Chinese medicine is removed impurity, cleaning, chopping;
(2) Testis et Pentis Canis is cleaned the back oven dry, cool subsequent use;
(3) Medulla Leporis seu Oryctolagi is removed the peel the film oven dry, cool subsequent use;
(4) get Radix Ginseng Rubra, Testis et Pentis Canis, Medulla Leporis seu Oryctolagi, succinum, Indigo Naturalis, Fructus Alpiniae Oxyphyllae, Rhizoma Acori Graminei pulverize separately, look over so as to check through 100 mesh sieves, it is subsequent use to be mixed into mixing fine powders;
(5) get Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Paeoniae Alba (parched), Radix Asparagi, Radix Ophiopogonis, Rhizoma Atractylodis Macrocephalae (parched), Herba Cistanches, Poria cum Radix Pini, Semen Ziziphi Spinosae (parched), processed with honey Radix Polygalae ten flavor decocte with water three times; Each amount of water is 6～8 times of ten flavor medicine gross weights; Decocted 2 hours for the first time; Decocted 1.5 hours for the second time, decocted for the third time 1.5 hours, with the filtrate for later use of three decoction liquor mixing after-filtration;
(6) above-mentioned filtrating is condensed into the extractum that relative density is 1.10～1.33 (90 ℃), subsequent use;
(7) in extractum, add mixing fine powders and appropriate amount of starch granulation, the Capsules of packing into is promptly processed this Chinese medicinal capsule.
Effect of the present invention
1, the present invention is owing to adopt Chinese medicine Radix Ginseng Rubra complement to take off admittedly; Testis et Pentis Canis the kidney warming, tonifying YANG, strengthening and nourishing marrow and essence, Medulla Leporis seu Oryctolagi are controlled tire and are produced unfavorable, chilblain, burn, chapped skin, Herba Cistanches kidney nourishing and replenishing vital essence, loosening bowel to relieve constipation; Poria cum Radix Pini's mind calming, calm the nerves, diuretic; Medicine such as other replenishing blood for nourishing heart of compatibility, invigorating the spleen and benefiting QI, the lung moistening and production of body fluid promoting, removing dampness appetizing and play the effect of the strong heart spleen of the kidney invigorating again, and can slow down aging, sexual function improvement, raising immunity, enhances human body function, therefore good efficacy is arranged.
2, oral administration of the present invention, taking convenience, short treating period, produce effects is fast, toxic and side effects is little, easy to carry.
3, raw material sources are abundant, and manufacture method is simple, and is with low cost.
Usage of the present invention: every capsule of adorning 0.32 gram, every day is early, middle and late respectively once, and each 2～4,15 days is a course of treatment.
Medicine of the present invention has carried out main pharmacodynamics, toxicological experiment, has carried out clinical observation on the therapeutic effect simultaneously, shows no obvious toxic-side effects, and normal taking dose is safe and effective.
Main pharmacodynamics experiment of the present invention shows:
1, delaying senility function
Chinese medicine 0.5% of the present invention and 1% concentration can make Drosophila melanogaster average life prolongation amplitude be: female fly is respectively 27.9% and 33.9%, and male fly is respectively 39.6% and 43%; 2.5% and 5% concentration can make the silkworm growth time prolong, and with the increase effect enhancing of dosage.Chinese medicine of the present invention can improve Radical Metabolism to increase oxidation resistance; Can improve the vigor of superoxide dismutase (SOD) in the rat erythrocyte; And the content of lipid peroxide in the reduction blood plasma, the enhancing that the effect that every day, ig gave 1.5g/kg is superior to the 0.6g/kg oxidation resistance helps the process of slow down aging.
2, the effect of sexual function improvement
Every day irritated clothes 0.8g/kg and 9g/kg by Chinese medicine of the present invention, can obviously increase the castration male mice and climb back of the body rate and climb back of the body number of times; High dose group can also alleviate the atrophy of accessory sex gland organs such as perineum complex and the prostate of castrated male Mus.1.5g/kg irritate clothes, can improve the sexual function reduction that suspention stress cause male mice; The content of testosterone in the rat serum that can also raise, and estradiol is not had obvious influence, testosterone/estradiol ratio is raise.These explain that all Chinese medicine of the present invention has certain yang invigorating functions.
3, Chinese medicine of the present invention can improve the immunity of rat, and every day, ig gave 0.6g/kg and 1.5g/kg, to IgG and erythrocyte C
3B receptor rosette rate and lymhocyte transformation rate have facilitation significantly.
4, Chinese medicine of the present invention has certain nootropic effect, and ethanol is caused that the dysmnesia of mice have improvement effect significantly.
5, Chinese medicine of the present invention has anti-stress effect, and every day, ig gave mice 0.6g/kg and 1.5g/kg, can obviously prolong the normal pressure anoxia enduring time-to-live of mice, and the swimming continuance time that prolongs mice, and is better with the high dose group effect.In addition, also has certain blood tonification effect, RBC and the Hb of the losing blood property mice that can obviously raise.
Toxicology test of the present invention shows:
Long term toxicity test shows; Chinese medicine of the present invention is by every day 3.1g, 1.5g, 0.61g/kg dosage (be equivalent to respectively clinical human dosage 40 times, 20 times, 8 times) 16 weeks of feed, and growth, growth, electrocardiogram, routine blood test, hepatic and renal function, blood fat and the blood glucose etc. of rat are not had obviously influence; The toxicity pathological changes that each main organs brain of postmortem and microscopy, the heart, liver, spleen, lung, kidney, pancreas, adrenal gland, thymus, testis, epididymis, uterus, ovary, stomach, intestinal are not seen medicine, visible Chinese medicine of the present invention long-term prescription in giving dosage does not have overt toxicity.
Animal acute toxicity test shows: the maximum tolerated dose of mouse stomach surpasses 250 times of clinical application amount greater than 19.2g/kg; LD50=4.29 ± the 0.79g/kg (p=0.95) of mouse peritoneal injection.
The present invention has given sufficient confirmation through to 1292 routine patient's clinical treatments so far from 1994.
1, Shuguang Hospital, Shanghai Second Medicine University subsidiary Renji Hospital Urology Surgery have been observed the therapeutical effect of Chinese medicine of the present invention to male sexual disorder clinically; And be matched group with remittance core SHENBAO, sildenafil citrate respectively, verify this medicine clinical efficacy.Be selected from outpatient service male patient totally 347 examples, being clarifies a diagnosis suffers from slight, moderate, completeness erection disturbance person.Chinese medicine clinic control obvious effective rate of the present invention is 40%, and total effective rate is 82.9%, all above converging the core SHENBAO; Compare with sildenafil citrate; Though it is lower slightly at aspects such as ED patient's erection, IIEF-5 scoring improvement; But improving patient's libido, improving and obviously be superior to matched group aspect other deficiency of the kidney yin, the deficiency of both the heart and spleen symptoms such as soreness of the waist and knees, palpitation and insomnia, spiritlessness and weakness; This medicine does not have the medication contraindication in addition, and untoward reaction is little.
Patient Liu Chengjun, the man, 52 years old, private prosecution hyposexuality 2 years was surplus, and because of being busy with one's work, hyposexuality gradually appears in overfatigue, and it is not hard to erect, and it is dissatisfied to have sexual intercourse.Conscious soreness of the waist and knees, easy fatigue is slept and feel unwell night, dizziness and tinnitus, light red tongue, thin fur, thready and weak pulse, card belong to the deficiency of kidney-essence card.It is on the low side to look into T, prompts for slight ED through the IIEF-5 scoring.Take Chinese medicine of the present invention 1 day 3 times, each 4, promptly felt the same day and sex drive is arranged and erect hard.Subjective symptoms disappears basically after one week, and libido obviously strengthens, and through efficacy evaluation, reaches recent healing.
Patient Zhou Gu, the man, 49 years old, once suffered from chronic prostatitis for many years, it is indifferent libido to occur, the difficulty of erecing, be difficult to have sexual intercourse 1 year surplus.With soreness of the waist and knees, spiritlessness and weakness, dizzy sometimes cardiopalmus, the tinnitus insomnia, light red tongue, white and thin fur, deep-thready pulse, card belong to the deficiency of kidney-essence card.Look into T, E2 is completeness ED all in normal range through the IIEF-5 scoring.Once took multiple Drug therapy, DeGrain.Take Chinese medicine of the present invention 1 day 3 times, each 4, serve on first quarter moon after, symptom disappears basically, has sexual intercourse to feel comparatively satisfied, continues to strengthen the treatment back and cures.
2, Affiliated Hospital of Medical University Of Anhui, Anhui Chinese Medicine College Affiliated Hospital, Anhui Chinese Medicine College Affiliated Hospital clinical verification cooperative groups, Provincial Hospital's clinical verification cooperative groups patient's totally 945 examples of using treatment by Chinese herbs deficiency of both the heart and spleen of the present invention and deficiency of kidney-essence card respectively, total effective rate is respectively 85.71%, 46.67%; 82.86%, 70%; 92.9%, 50%, the comprehensive total effective rate of treatment syndrome of deficiency of both heart and spleen is 87.16%, and the comprehensive total effective rate of treatment deficiency of kidney-essence card is 55.56%.
Patient Lu Wen, the woman, 41 years old, due to illness viral myocarditis was 4 years, occurs severe palpitation repeatedly, insomnia and dreamful sleep; Sensation of oppression over the chest with shortness of breath, dizzy weak, the poor appetite pale tongue, irregularly intermittent and regularly intermittent pulse, the electrocardio diagram: the chamber of taking place frequently early is premature ventricular beat, and card belongs to deficiency of both the heart and spleen disease; Take Chinese medicine of the present invention, every day three times, each 4, serve on one month, the check electrocardiogram; Basically normal, subjective symptoms is obviously improved, and irregularly intermittent and regularly intermittent pulse disappears, and curative effect is rather good, recovers after continuing to strengthen treatment.
Patient Dai Shunyi, the woman, 38 years old, because of the surplus prescription on individual diagnosis in a year of having a sleepless night repeatedly, the time have uncomfortable in chest; Cardiopalmus, dizzy weak, weak digestive function of the spleen and stomach was once taken the stable tranquilizer not radical cure eventually that waits for a long time, and body of the tongue serves as a contrast purple thin fur thready pulse; Card belongs to being insomnia of deficiency of both the heart and spleen, takes Chinese medicine of the present invention, every day three times, each 4, serve on one month after; Symptom is obviously improved, and prolong the length of one's sleep, and spiritual amelioration is recovered.
Patient Wang Jun, the man, 36 years old, it was surplus sexual impotence, premature ejaculation 2 years to occur, accompanies dizzy waist knee joint weak; Spiritlessness and weakness, extremity are not warm, shortness of breath and palpitation, pale tongue, deep-thready pulse; Impotence and premature ejaculation due to the card genus deficiency of kidney-essence promptly gives Chinese medicine of the present invention, each 4, every day three times, serve on 20 days; Subjective symptoms is obviously alleviated, and continues to strengthen treatment and takes 10 days, and erection is strong, and sexual life is normal, cures.
Patient Liu Shitao, the man 28 years old, suffered from prostatitis sick nearly 5 years.Occur impotence and premature ejaculation in this year, sexual hypofunction can not be crossed normality life, accompanies simultaneously that the waist knee joint is weak, dizzy, spiritlessness and weakness, cold extremities with aversion to cold; Pale tongue, thin fur, deep-thready pulse, card belongs to the sexual impotence of deficiency of kidney-essence, takes Chinese medicine of the present invention; Each 4, every day three times, serve on one month; Symptom is obviously improved, and erection is strong, cures.
The specific embodiment
Embodiment 1:
Each herbal raw material is removed impurity, cleaning, chopping; Testis et Pentis Canis is cleaned the back oven dry, cool subsequent use; Medulla Leporis seu Oryctolagi is removed the peel the film oven dry, cool subsequent use.Get Radix Ginseng Rubra 14.5g, Testis et Pentis Canis 57g, Medulla Leporis seu Oryctolagi 8.5g, succinum 6.8g, Indigo Naturalis 6.8g, Fructus Alpiniae Oxyphyllae 21.3g, Rhizoma Acori Graminei 14.5g pulverize separately, look over so as to check through 100 mesh sieves, it is subsequent use to be mixed into mixing fine powders; Get Radix Rehmanniae Preparata 70.6g, Radix Angelicae Sinensis 28.1g, Radix Paeoniae Alba (parched) 21.3g, Radix Asparagi 21.3g, Radix Ophiopogonis 21.3g, Rhizoma Atractylodis Macrocephalae (parched) 21.3g, Herba Cistanches 28.1g, Poria cum Radix Pini 42.5g, Semen Ziziphi Spinosae (parched) 28.1g, processed with honey Radix Polygalae 14.5g ten flavor decocte with water three times; Each amount of water is 6～8 times of ten flavor medicine gross weights; Decocted 2 hours for the first time; Decocted 1.5 hours for the second time, decocted for the third time 1.5 hours, with the filtrate for later use of three decoction liquor mixing after-filtration; Again filtrating is condensed into the extractum that relative density is 1.10～1.33 (90 ℃), subsequent use.In extractum, add mixing fine powders and appropriate amount of starch granulation, the Capsules of packing into is promptly processed this Chinese medicinal capsule.
Embodiment 2:
Each herbal raw material is removed impurity, cleaning, chopping; Testis et Pentis Canis is cleaned the back oven dry, cool subsequent use; Medulla Leporis seu Oryctolagi is removed the peel the film oven dry, cool subsequent use.Get Radix Ginseng Rubra 19.6g, Testis et Pentis Canis 77.1g, Medulla Leporis seu Oryctolagi 11.5g, succinum 9.2g, Indigo Naturalis 9.2g, Fructus Alpiniae Oxyphyllae 28.8g, Rhizoma Acori Graminei 19.6g pulverize separately, look over so as to check through 100 mesh sieves, it is subsequent use to be mixed into mixing fine powders; Get Radix Rehmanniae Preparata 95.5g, Radix Angelicae Sinensis 38g, Radix Paeoniae Alba (parched) 28.8g, Radix Asparagi 28.8g, Radix Ophiopogonis 28.8g, Rhizoma Atractylodis Macrocephalae (parched) 28.8g, Herba Cistanches 38g, Poria cum Radix Pini 57.5g, Semen Ziziphi Spinosae (parched) 38g, processed with honey Radix Polygalae 19.6g ten flavor decocte with water three times; Each amount of water is 6～8 times of ten flavor medicine gross weights; Decocted 2 hours for the first time; Decocted 1.5 hours for the second time, decocted for the third time 1.5 hours, with the filtrate for later use of three decoction liquor mixing after-filtration; Again filtrating is condensed into the extractum that relative density is 1.10～1.33 (90 ℃), subsequent use.In extractum, add mixing fine powders and appropriate amount of starch granulation, the Capsules of packing into is promptly processed this Chinese medicinal capsule.
Embodiment 3:
Each herbal raw material is removed impurity, cleaning, chopping; Testis et Pentis Canis is cleaned the back oven dry, cool subsequent use; Medulla Leporis seu Oryctolagi is removed the peel the film oven dry, cool subsequent use.Get Radix Ginseng Rubra 17g, Testis et Pentis Canis 67g, Medulla Leporis seu Oryctolagi 10g, succinum 8g, Indigo Naturalis 8g, Fructus Alpiniae Oxyphyllae 25g, Rhizoma Acori Graminei 17g pulverize separately, look over so as to check through 100 mesh sieves, it is subsequent use to be mixed into mixing fine powders; Get Radix Rehmanniae Preparata 83g, Radix Angelicae Sinensis 33g, Radix Paeoniae Alba (parched) 25g, Radix Asparagi 25g, Radix Ophiopogonis 25g, Rhizoma Atractylodis Macrocephalae (parched) 25g, Herba Cistanches 33g, Poria cum Radix Pini 50g, Semen Ziziphi Spinosae (parched) 33g, processed with honey Radix Polygalae 17g ten flavor decocte with water three times; Each amount of water is 6～8 times of ten flavor medicine gross weights; Decocted 2 hours for the first time; Decocted 1.5 hours for the second time, decocted for the third time 1.5 hours, with the filtrate for later use of three decoction liquor mixing after-filtration; Again filtrating is condensed into the extractum that relative density is 1.10～1.33 (90 ℃), subsequent use.In extractum, add mixing fine powders and appropriate amount of starch granulation, the Capsules of packing into is promptly processed this Chinese medicinal capsule.
Claims (1)
1. the Chinese medicine of a kidney invigorating, strong heart spleen, enhances human body function is characterized in that being processed by following raw material, and its weight portion is:
Its preparation method is:
(1) each raw material of Chinese medicine is removed impurity, cleaning, chopping;
(2) Testis et Pentis Canis is cleaned the back oven dry, cool subsequent use;
(3) Medulla Leporis seu Oryctolagi is removed the peel the film oven dry, cool subsequent use.
(4) get Radix Ginseng Rubra, Testis et Pentis Canis, Medulla Leporis seu Oryctolagi, succinum, Indigo Naturalis, Fructus Alpiniae Oxyphyllae, Rhizoma Acori Graminei pulverize separately, look over so as to check through 100 mesh sieves, it is subsequent use to be mixed into mixing fine powders;
(5) get Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Paeoniae Alba (parched), Radix Asparagi, Radix Ophiopogonis, Rhizoma Atractylodis Macrocephalae (parched), Herba Cistanches, Poria cum Radix Pini, Semen Ziziphi Spinosae (parched), processed with honey Radix Polygalae ten flavor decocte with water three times; Each amount of water is 6～8 times of ten flavor medicine gross weights; Decocted 2 hours for the first time; Decocted 1.5 hours for the second time, decocted for the third time 1.5 hours, with the filtrate for later use of three decoction liquor mixing after-filtration;
(6) above-mentioned filtrating is condensed into the extractum that relative density is 1.10～1.33 (90 ℃), subsequent use;
(7) in extractum, add mixing fine powders and appropriate amount of starch granulation, the Capsules of packing into is promptly processed this Chinese medicinal capsule.
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Citations (5)
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| CN1167638A (en) * | 1997-06-05 | 1997-12-17 | 廖开福 | Liquor for strengthening Yang |
| CN1171970A (en) * | 1997-06-26 | 1998-02-04 | 周淑琴 | Health-care wine with antisenility function |
| CN1270052A (en) * | 1999-04-13 | 2000-10-18 | 程谦才 | Medicinal composition for relieving sexual fatigue and delaying sanility and preparing process thereof |
| CN1476878A (en) * | 2003-04-28 | 2004-02-25 | 李永胜 | Medicine tea with function of raising immunity, resisting fatigue and preventing impotence and prospermia |
| CN1868520A (en) * | 2005-05-23 | 2006-11-29 | 长春市新安药业集团有限公司 | Compound Barbados aloe soft-capsule prepn. and its preparing method |
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2009
- 2009-02-20 CN CN2009101162182A patent/CN101485857B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1167638A (en) * | 1997-06-05 | 1997-12-17 | 廖开福 | Liquor for strengthening Yang |
| CN1171970A (en) * | 1997-06-26 | 1998-02-04 | 周淑琴 | Health-care wine with antisenility function |
| CN1270052A (en) * | 1999-04-13 | 2000-10-18 | 程谦才 | Medicinal composition for relieving sexual fatigue and delaying sanility and preparing process thereof |
| CN1476878A (en) * | 2003-04-28 | 2004-02-25 | 李永胜 | Medicine tea with function of raising immunity, resisting fatigue and preventing impotence and prospermia |
| CN1868520A (en) * | 2005-05-23 | 2006-11-29 | 长春市新安药业集团有限公司 | Compound Barbados aloe soft-capsule prepn. and its preparing method |
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| Title |
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Address after: 241000 No.10, Fengming Hunan Road, Wuhu District, Wuhu pilot Free Trade Zone, Anhui Province Patentee after: Anhui zhanghengchun Pharmaceutical Co.,Ltd. Address before: 241009 Anhui city of Wuhu Province, Hunan Road economic and Technological Development Zone No. 10 Patentee before: WUHU ZHANGHENGCHUN MEDICINE Co.,Ltd. |