CN103494934B - A kind of Sugarless type blood-nourishing oral liquid with nine ingredients and preparation method thereof - Google Patents
A kind of Sugarless type blood-nourishing oral liquid with nine ingredients and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to technical field is traditional Chinese medicine preparation technical field, in particular to a kind of Sugarless type blood-nourishing oral liquid with nine ingredients and preparation method thereof, it is characterized in that, Sugarless type blood-nourishing oral liquid with nine ingredients is prepared from by Chinese medicine ingredients Radix Ginseng, the Radix Astragali, Herb Gynostemmae Pentaphylli, Fructus Schisandrae Chinensis, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Fructus Crataegi, Radix Glycyrrhizae and adjuvant ethyl hydroxybenzoate and sweeting agent.The present invention's sweeting agent replaces the sugar composition of original blood-nourishing oral liquid with nine ingredients, and the sugar avoiding patients such as hypertension, obesity, diabetes, heart disease also can be taken.Described Sugarless type blood-nourishing oral liquid with nine ingredients, by improving endocrine and the metabolic function of human organism, improves human body autologous hematopoietic function, reaches qi and blood tonifying, complete treatment anemia, have the function of vigorate qi and replenish the blood, invigorating spleen and reinforcing stomach.In a word, the sweeting agent of safety non-toxic of the present invention, use low calorie replaces sucrose, and improve the bitterness of Chinese medicine, mouthfeel is good, makes patient be easy to accept.
Description
Technical field
The present invention relates to traditional Chinese medicine preparation technical field, particularly a kind of Sugarless type blood-nourishing oral liquid with nine ingredients and preparation method thereof.
Background technology
Anemia is a series of coexpress symptoms that many different reasons or disease cause, common are iron deficiency anemia, aplastic anemia, hemolytic anemia, hemorrhagic anemia, megaloblastic anemia clinically, the diseases such as chronic hepatitis, infection, malignant tumor all can occur together anemia.Suffer from the hemoglobin reduction of anemia descendant, blood oxygen carrying capacity reduces, body tissue and organ generation anoxia, thus causes tired, weak, dizzy, dim eyesight, tinnitus, hypomnesis, the symptom such as absent minded, larger to human health damage.
The emergence of modern industry, global economy is rapidly developed, but the environment of human survival is also subject to severe contamination, add nervous study, work, rhythm of life, result in global anemia sickness rate is obvious growth trend, and the current whole world has suffers from anemia in various degree more than 3,000,000,000 people, and China is one of anemia district occurred frequently, suffer from about 600,000,000 people of number of anemia, therefore hematonic has very huge market prospect.
The product of current this type of disease of control has chemicals class, integration of edible and medicinal herbs class, Chinese patent medicine class etc.; What chemicals class was conventional has the medicines such as iron supplementary, bone marrow analeptic and hormones, cure the symptoms, not the disease, and side effect is larger, along with the mankind are to the awareness and understanding of doctor trained in Western medicine limitation and Western medicine toxic and side effects, add that the upsurge of mankind's " back to nature " is constantly surging, Chinese medicine is progressively got the nod in prevention, disease therapy, creates advantage and broad mass market to the research and development of Chinese patent medicine vigorate qi and replenish the blood quasi drugs.
Be the adjustment that sweeting agent carries out mouthfeel with sucrose in original blood-nourishing oral liquid with nine ingredients, be unsuitable for the sugar avoiding patients such as hypertension, obesity, diabetes, heart disease and take, limit applying of product.Limiting the above-mentioned drawback of avoiding sugared crowd and using for making up sucrose as sweeting agent, the invention provides a kind of Sugarless type blood-nourishing oral liquid with nine ingredients.
Summary of the invention
The object of the invention is to improve existing blood-nourishing oral liquid with nine ingredients and preparation method thereof, replace sucrose with the compositions of one or more in sweeting agent stevioside, aspartame, cyclamate, glycyrrhizin, mannitol, sorbitol, solve the sugar avoiding patients such as hypertension, obesity, diabetes, heart disease and take limited drawback.
For solving the problems of the technologies described above, the invention provides a kind of Sugarless type blood-nourishing oral liquid with nine ingredients, it is characterized in that, be prepared from by the Chinese medicine ingredients of following weight portion and adjuvant:
Chinese medicine ingredients: Radix Ginseng 55 ~ 100, the Radix Astragali 80 ~ 110, Herb Gynostemmae Pentaphylli 90 ~ 115, Fructus Schisandrae Chinensis 80 ~ 110, Radix Angelicae Sinensis 55 ~ 80, the Rhizoma Atractylodis Macrocephalae 30 ~ 70, Pericarpium Citri Reticulatae 10 ~ 50, Fructus Crataegi 30 ~ 80, Radix Glycyrrhizae 15 ~ 40, adjuvant is ethyl hydroxybenzoate 0.5 ~ 1 and sweeting agent 10 ~ 400.
Preferably, be prepared from by the Chinese medicine ingredients of following weight portion and adjuvant:
Chinese medicine ingredients: Radix Ginseng 75, the Radix Astragali 100, Herb Gynostemmae Pentaphylli 100, Fructus Schisandrae Chinensis 100, Radix Angelicae Sinensis 75, the Rhizoma Atractylodis Macrocephalae 50, Pericarpium Citri Reticulatae 30, Fructus Crataegi 50, Radix Glycyrrhizae 30, adjuvant is ethyl hydroxybenzoate 0.5 and sweeting agent 10 ~ 400.Described sweeting agent is one or more the compositions in stevioside, aspartame, cyclamate, glycyrrhizin, mannitol and sorbitol.
Preferably, in described oral liquid, the weight portion of sweeting agent is: stevioside 1 ~ 50 or aspartame 1 ~ 30 or cyclamate 1 ~ 50 or glycyrrhizin 1 ~ 50 or mannitol 50 ~ 400 or sorbitol 50 ~ 400.
Preferably, in described oral liquid, the weight portion of sweeting agent is: the compositions 150 ~ 300 that stevioside and mannitol are mixed into for 1:200 ~ 1:50 in mass ratio, or the compositions 150 ~ 300 that stevioside and sorbitol are mixed into for 1:200 ~ 1:50 in mass ratio.
Preferably, in described oral liquid, the weight portion of sweeting agent is: the compositions 150 ~ 300 that aspartame and mannitol are mixed into for 1:150 ~ 1:55 in mass ratio, or the compositions 150 ~ 300 that aspartame and sorbitol are mixed into for 1:150 ~ 1:55 in mass ratio.
Preferably, in described oral liquid, the volumetric concentration of sweeting agent is: the compositions 150 ~ 300 that glycyrrhizin and mannitol are mixed into for 1:200 ~ 1:80 in mass ratio, or the compositions 150 ~ 300 that glycyrrhizin and sorbitol are mixed into for 1:200 ~ 1:80 in mass ratio.
Preferably, in described oral liquid, the weight portion of sweeting agent is: the compositions 150 ~ 300 that cyclamate and mannitol are mixed into for 1:220 ~ 1:85 in mass ratio, or the compositions 150 ~ 300 that cyclamate and sorbitol are mixed into for 1:220 ~ 1:85 in mass ratio.
Preferably, in described oral liquid, the weight portion of sweeting agent is: the compositions 200 ~ 350 that stevioside, aspartame, glycyrrhizin and mannitol are mixed into for 1:1:1:300 ~ 3:2:2:50 in mass ratio, or the compositions 200 ~ 350 that stevioside, aspartame, glycyrrhizin and sorbitol are mixed into for 1:1:1:300 ~ 3:2:2:50 in mass ratio.
A preparation method for Sugarless type blood-nourishing oral liquid with nine ingredients, is characterized in that, comprises the following steps:
1) Radix Ginseng, Herb Gynostemmae Pentaphylli, Fructus Schisandrae Chinensis, Pericarpium Citri Reticulatae and Radix Angelicae Sinensis is taken, each component with the consumption of parts by weight be Radix Ginseng 55 ~ 100, Herb Gynostemmae Pentaphylli 90 ~ 115, Fructus Schisandrae Chinensis 80 ~ 110, Pericarpium Citri Reticulatae 10 ~ 50 and Radix Angelicae Sinensis 55 ~ 80, each component is ground into coarse powder carry out quick-freezing at-18 ~-30 DEG C after respectively, for subsequent use;
2) Radix Ginseng coarse powder, Herb Gynostemmae Pentaphylli coarse powder and Fructus Schisandrae Chinensis coarse powder are mixed to get first part of coarse powder mixture, volume ratio is that 1:8 ~ 1:15 adds the ethanol that concentration of volume percent is 65 ~ 75% in described first part of coarse powder mixture by weight, after flooding described first part of coarse powder mixture 22 ~ 26h, with 2 ~ 4mL/min percolation, collect percolate to 2000 ~ 2400ml, obtain the first coarse powder percolate and first part of medicinal residues, for subsequent use;
3) Pericarpium Citri Reticulatae coarse powder and Radix Angelicae Sinensis coarse powder are mixed to get second part of coarse powder mixture, volume ratio is that 1:8 ~ 1:15 adds the ethanol that concentration of volume percent is 50 ~ 60% in described second part of coarse powder mixture by weight, after flooding described second part of coarse powder mixture 22 ~ 26h, with 2 ~ 4mL/min percolation, collect percolate to 800 ~ 900ml, obtain the second coarse powder percolate and second part of medicinal residues, for subsequent use;
4) after described first coarse powder percolate and the second coarse powder percolate are merged, be concentrated into the clear paste that relative density is 1.05 ~ 1.10 at temperature 75 ~ 85 DEG C of decompression recycling ethanols, cold preservation 20 ~ 30 hours, get supernatant, filter, the clear paste that relative density is 1.12 ~ 1.20 is evaporated to temperature 75 ~ 85 DEG C, for subsequent use;
5) Radix Astragali is taken, the Rhizoma Atractylodis Macrocephalae, Fructus Crataegi and Radix Glycyrrhizae, each component with the consumption of parts by weight for the Radix Astragali 80 ~ 110, the Rhizoma Atractylodis Macrocephalae 30 ~ 70, Fructus Crataegi 30 ~ 80 and Radix Glycyrrhizae 15 ~ 40, and by the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Fructus Crataegi, Radix Glycyrrhizae and described first part of medicinal residues and described second part of medicinal residues are mixed to get medicinal mixture, afterwards, add water in described medicinal mixture by 6 ~ 10 times of weight, carry out first time decoction, decocting time is 2 ~ 3h for the first time, filtration obtains the first decocting liquid, carry out second time again to decoct, second time decocting time is 1 ~ 2h, filtration obtains the second decocting liquid, merge described first decocting liquid and described second decocting liquid, leave standstill 20 ~ 30h, filter, gained filtrate is evaporated to temperature 75 ~ 85 DEG C the secondary clear paste that relative density is 1.12 ~ 1.20, for subsequent use,
6) secondary clear paste is processed: in described secondary clear paste, add for 1:2 ~ 1:4 the ethanol that concentration of volume percent is 50 ~ 70% by volume, convention stir 5 ~ 10min, leave standstill 24h, separated secondary supernatant and secondary lower sediment thing, after getting secondary supernatant recovery ethanol, add described first time clear paste, be evaporated at temperature 75-85 DEG C three clear paste that relative density is 1.12 ~ 1.20;
7) by described three clear paste mass percent concentrations be 40% sodium hydroxide solution adjust pH to 6.0 ~ 7.0, leave standstill 24h, filter to get filtrate, in described filtrate, add sweeting agent 10 ~ 400g and ethyl hydroxybenzoate 0.5 ~ 1g, add water and be mixed with 1000ml, stir evenly, fill, sterilizing, packaging, inspection, obtains Sugarless type blood-nourishing oral liquid with nine ingredients; Wherein, described step 4), 5), 6) in relate to the mensuration of clear paste relative density, it measures temperature and is 70 DEG C.
In the preparation method of Sugarless type blood-nourishing oral liquid with nine ingredients of the present invention, add all by volume when adding alcoholic solution in the coarse powder or clear paste of Chinese medicine ingredients, can guarantee that coarse powder or the clear paste of Chinese medicine ingredients can be dipped in alcoholic solution completely like this, and sufficient stripping medicinal ingredient.
Gas is the motive power of human physiological activity, is that human body sustains life the most base substance of activity; Blood runs the nutrient substance in arteries and veins, has the physiological function of nutrition and moist whole body, is also one of base substance maintaining human life activity.This Sugarless type blood-nourishing oral liquid with nine ingredients establishes for QI and blood deficiency person, qi-blood deficiency syndrome system is because causing internal organs QI and blood biochemical function to fail after ferritic innate deficiency or serious disease, prolonged illness, especially in, burnt taste source is not enough, the deficiency of vital energy is caused to involve blood deficiency, or blood deficiency causes the deficiency of vital energy, thus there is qi-blood deficiency syndrome.Insufficiency of vital energy and blood, be difficult the flourish head, brain is become homeless foster, therefore sees and have a dizzy spell, and spiritlessness and weakness, lustreless complexion, insufficiency of vital energy and blood, heart spleen virtual loss, blood failing to tonify the heart, be then shown in severe palpitation, the diseases such as cold sweating, insomnia forgetfulness, indigestion and loss of appetite lack of appetite of losing heart.Controlling of assertive evidence, when avenging as the rule for the treatment of with QI invigorating benefit.
Radix Ginseng in material choice, strongly invigorating primordial QI, invigorating spleen and reinforcing stomach, mind tranquilizing and the heart calming, Radix Astragali replenishing QI to invigorate the spleen, the same use of ginseng stilbene, the power of its air making-up and spleen enlivening is stronger, and energy QI invigorating is with hemopoietic.Gai Yin " tangible blood is born in invisible gas ", " the prosperous blood of gas is spontaneous ", this also " Yin grows while yang is generating " justice also.Therefore ginseng, monarch drug in the stilbene side of being.
The traditional Chinese medical science is thought, and " The spleen and stomach provide the material basis of the acquired, source of generating QI and blood." in event side again with the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae and Radix Ginseng, it has the merit of invigorating the spleen and benefiting QI, stomach function regulating.Spleen health movement, then source of generating QI and blood is sufficient.Therefore above each medicine can strengthen the merit of monarch drug ginseng stilbene invigorating qi and benefiting blood, is be the ministerial drug in side.The benefiting blood and regulating blood circulation of Radix Angelicae Sinensis in side; Fructus Schisandrae Chinensis supplementing QI for promoting the production of body fluid; Herb Gynostemmae Pentaphylli is rich in gypenoside and ginsenoside, clinical practice, has the function of similar Radix Ginseng, therefore has the merit of supplementing QI for promoting the production of body fluid.Each medicine shares, and function strengthens the merit of monarch drug vigorate qi and replenish the blood, the ministerial drug also in the side of being all.
Fructus Crataegi in side, sour sweet tepor, has digestion-promoting spleen-invigorating, the merit of circulation of qi promoting dissipating blood stasis, is be adjuvant drug in side.
Sweet flat, the coordinating the actions of various ingredients in a prescription of Radix Glycyrrhizae is for making medicine in side.
All medicines share above, play vigorate qi and replenish the blood altogether, the merit of invigorating spleen and reinforcing stomach.For the insomnia forgetfulness of QI and blood deficiency, cardiopalmus severe palpitation, has a dizzy spell, spiritlessness and weakness, the treatment of lose heart spontaneous perspiration, the diseases such as indigestion and loss of appetite lack of appetite.Informal dress can improve resistance against diseases, the slow down aging of body.
Stevioside is also known as making stevioside, and leaf of Folium Stevlae Rebaudianae seed extract, not containing sugar and heat; Color and luster white is to micro-yellow, and mouthfeel is suitable, free from extraneous odour, is the wide new sugared source of development prospect.Stevioside is that the current world has found and the sweeting agent used through the approval of China Ministry of Public Health, its natural low caloric value and closely sucrose taste.
Be the powder of white crystalline under aspartame room temperature, sweet taste is high, heat is low, mainly makes an addition to the use that beverage, vitamin buccal tablet or chewing gum replace sugar.Many diabeticss, fat-reducing personage are with the succedaneum of aspartame as sugar
Cyclamate, its chemical name is sodium cyclamate, is additive conventional in food production.Cyclamate is a kind of conventional sweeting agent, and its sugariness is 30 ~ 40 times of sucrose.
Glycyrrhizin is the effective ingredient of Radix Glycyrrhizae sweet taste, it is the very promising pure natural sweeting agent of one, its sugariness is approximately sucrose 80 ~ 300 times, low calorie, safety non-toxic and stronger medicinal health care function, be the most desirable sweeting agent of hypertension, obesity, diabetes, cardiac's use, it can make up sucrose essence and wait sweeting agent to bring out the drawback of above-mentioned disease.
Mannitol mainly with Thallus Laminariae (Thallus Eckloniae) or with sucrose and glucose for raw material is for obtaining, be the Sweet flavor modifier of safety non-toxic, its sugariness is equivalent to 70% of sucrose.
Sorbitol is white crystalline powder, and odorless has refrigerant sweet taste, soluble in water, and be insoluble in organic solvent, it is acidproof, and heat resistance is good, and with aminoacid, protein etc. not easily play Maillard reaction.Its sugariness is about 50% ~ 70% of sucrose.1GD-Sorbitol produces 16.722 heats in human body.In blood, be not converted into glucose after edible, also do not affect by insulin.
Sweeting agent of the present invention is one or more the compositions in stevioside, aspartame, cyclamate, glycyrrhizin, mannitol and sorbitol, both can meet the mouthfeel needs of Sugarless type blood-nourishing oral liquid with nine ingredients, hypertension, obesity, diabetes or heart patient also can be avoided to take Sugarless type blood-nourishing oral liquid with nine ingredients of the present invention generation untoward reaction and are reaching the object of enriching blood.
The invention has the beneficial effects as follows that the medicinal ingredient in Sugarless type blood-nourishing oral liquid with nine ingredients of the present invention is natural Chinese medicine, safe and reliable, have no side effect.In oral liquid, add sweeting agent in process of production replace original sugar composition, not only do not affect original mouthfeel, and expand the scope of drug administration crowd, make originally can not to be supplied to the medicine of hypertension, obesity, diabetes or heart patient, also them can be allowed to take by normal dosage, can not affect healthy, reach the object of enriching blood simultaneously; First will the Chinese medicine of the five flavours of percolation be needed to carry out fast frozen in the preparation method of Sugarless type blood-nourishing oral liquid with nine ingredients, pulverize again afterwards, good crushing effect can be made, medicated powder uniform particles, improve the cutting rate of cell in Chinese medicine, making Chinese medicine can make the better stripping of medicinal ingredient when carrying out alcohol dipping, improving drug effect.Step 2 in preparation method of the present invention) and step 3) use the ethanol of different volumes percent concentration to carry out percolation respectively to first part of coarse powder mixture and second part of coarse powder mixture, set according to the dissolution characteristics of Effective Component of Chinese Medicine, more can ensure that in this product, extracts active ingredients is complete, improves drug effect.Described Sugarless type blood-nourishing oral liquid with nine ingredients, by improving endocrine and the metabolic function of human organism, improves human body autologous hematopoietic function, reaches qi and blood tonifying, complete treatment anemia, have the function of vigorate qi and replenish the blood, invigorating spleen and reinforcing stomach.In a word, the sweeting agent of safety non-toxic of the present invention, use low calorie replaces sucrose, improves the bitterness of Chinese medicine, mouthfeel is good, make patient be easy to accept, solve the sugar avoiding patients such as hypertension, obesity, diabetes, heart disease and take limited drawback, expand the range of application of product.
Detailed description of the invention
In order to further illustrate the present invention, below in conjunction with embodiment, Sugarless type blood-nourishing oral liquid with nine ingredients provided by the invention and preparation method thereof being described in detail, but they can not being interpreted as limiting the scope of the present invention.
Table 1
The each embodiment for single dose sweeting agent of table 1 for adding in described Sugarless type blood-nourishing oral liquid with nine ingredients.
Table 2
Table 2 for adding each embodiment of composite sweetener in described Sugarless type blood-nourishing oral liquid with nine ingredients
Embodiment 41
Carry out the preparation of oral liquid according to the preparation method of table 1 and table 2 and blood-nourishing oral liquid with nine ingredients, concrete preparation method is:
1) Radix Ginseng, Herb Gynostemmae Pentaphylli, Fructus Schisandrae Chinensis, Pericarpium Citri Reticulatae and Radix Angelicae Sinensis is taken, each component with the consumption of parts by weight be Radix Ginseng 55 ~ 100, Herb Gynostemmae Pentaphylli 90 ~ 115, Fructus Schisandrae Chinensis 80 ~ 110, Pericarpium Citri Reticulatae 10 ~ 50 and Radix Angelicae Sinensis 55 ~ 80, each component is ground into coarse powder carry out quick-freezing at-18 ~-30 DEG C after respectively, for subsequent use;
2) Radix Ginseng coarse powder, Herb Gynostemmae Pentaphylli coarse powder and Fructus Schisandrae Chinensis coarse powder are mixed to get first part of coarse powder mixture, volume ratio is that 1:8 ~ 1:15 adds the ethanol that concentration of volume percent is 65 ~ 75% in described first part of coarse powder mixture by weight, after flooding described first part of coarse powder mixture 22 ~ 26h, with 2 ~ 4mL/min percolation, collect percolate to 2000 ~ 2400ml, obtain the first coarse powder percolate and first part of medicinal residues, for subsequent use;
3) Pericarpium Citri Reticulatae coarse powder and Radix Angelicae Sinensis coarse powder are mixed to get second part of coarse powder mixture, volume ratio is that 1:8 ~ 1:15 adds the ethanol that concentration of volume percent is 50 ~ 60% in described second part of coarse powder mixture by weight, after flooding described second part of coarse powder mixture 22 ~ 26h, with 2 ~ 4mL/min percolation, collect percolate to 800 ~ 900ml, obtain the second coarse powder percolate and second part of medicinal residues, for subsequent use;
4) after described first coarse powder percolate and the second coarse powder percolate are merged, be concentrated into the clear paste that relative density is 1.05 ~ 1.10 at temperature 75 ~ 85 DEG C of decompression recycling ethanols, cold preservation 20-30 hour, get supernatant, considered, at a clear paste of temperature 75 ~ 85 DEG C of concentrating under reduced pressure 1.12 ~ 1.20, for subsequent use;
5) Radix Astragali is taken, the Rhizoma Atractylodis Macrocephalae, Fructus Crataegi and Radix Glycyrrhizae, each component with the consumption of parts by weight for the Radix Astragali 80 ~ 110, the Rhizoma Atractylodis Macrocephalae 30 ~ 70, Fructus Crataegi 30 ~ 80 and Radix Glycyrrhizae 15 ~ 40, and by the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Fructus Crataegi, Radix Glycyrrhizae and described first part of medicinal residues and described second part of medicinal residues are mixed to get medicinal mixture, afterwards, add water in described medicinal mixture by 6 ~ 10 times of weight, carry out first time decoction, decocting time is 2 ~ 3h for the first time, filtration obtains the first decocting liquid, carry out second time again to decoct, second time decocting time is 1 ~ 2h, filtration obtains the second decocting liquid, merge described first decocting liquid and described second decocting liquid, leave standstill 20 ~ 30h, filter, gained filtrate is evaporated at temperature 75-85 DEG C the secondary clear paste that relative density is 1.12 ~ 1.20, for subsequent use,
6) secondary clear paste is processed: in described secondary clear paste, add for 1:2 ~ 1:4 the ethanol that concentration of volume percent is 50 ~ 70% by volume, convention stir 5 ~ 10min, leave standstill 24h, separated secondary supernatant and secondary lower sediment thing, after getting secondary supernatant recovery ethanol, add described first time clear paste, be evaporated at temperature 75-85 DEG C three clear paste that relative density is 1.12 ~ 1.20;
7) by described three clear paste mass percent concentrations be 40% sodium hydroxide solution adjust pH to 6.0 ~ 7.0, leave standstill 24h, filter to get filtrate, in described filtrate, add sweeting agent 10 ~ 400g and ethyl hydroxybenzoate 0.5 ~ 1g, add water and be mixed with 1000ml, stir evenly, fill, sterilizing, packaging, inspection, obtains Sugarless type blood-nourishing oral liquid with nine ingredients; Wherein, described step 4), 5), 6) in relate to the mensuration of clear paste relative density, it measures temperature and is 70 DEG C.
The occupation mode of Sugarless type blood-enriching oral liquid of the present invention is, each 10mL, is used in conjunction 15 at every day 3 times.
Good according to the sugar-free oral liquid mouthfeel that proportioning in the various embodiments described above is obtained, have no side effect, the Anemic patients being suitable for comprising the sugar avoiding patients such as hypertension, obesity, diabetes or heart disease takes.
Through carrying out Clinical efficacy and safety test, choose anemia case 150 example altogether to comprise: 50 routine heart disease Anemic patients, 50 routine diabetic anemia patients and 50 routine common Anemic patients, reference examples 80 example, after treatment, peripheral blood Hb content obviously increases, display Sugarless type blood-nourishing oral liquid with nine ingredients can improve Hb content in blood of human body, and 50 routine heart diseases with exsanguine patient, 50 routine diabetes also only have exsanguine patient not have what untoward reaction with exsanguine patient and 50 examples, total effective rate is respectively 92.3%, 91.8% and 89.7%, to take Donky-hide blood-supplementing tonic curative effect close with matched group.
Model case
Example 1
Bai, female, 46 years old, peasant.Dizzy, weak, loss of appetite, nervous after movable, thready pulse, breathe hard about 1 year, Chinese medical discrimination belongs to insufficiency of vital energy and blood disease, is diabetics simultaneously.Take Sugarless type blood-enriching oral liquid of the present invention every day, each 10mL, every day 3 times.After taking medicine 7 days, dizzy number of times reduces, and appetite strengthens, and after taking medicine 15 days, dizzy symptom obviously reduces, and complexion is gradually red, and mental restoration is normal.Blood routine examination, blood sugar content does not significantly raise, and Hb content becomes the 121g/L after treatment from original 101g/L.
Example 2
Zhao, man, 38 years old, workman.Cardiopalmus, shortness of breath and fatigue, loss of appetite, deficiency of QI with disinclination to talk, spiritlessness and weakness about 2 years, pale tongue, thready pulse not flourish with pale complexion, hair, breathe hard, and Chinese medical discrimination belongs to insufficiency of vital energy and blood disease, simultaneously with myocardial ischemia.Take western medicine result undesirable, turn and take Sugarless type blood-nourishing oral liquid with nine ingredients of the present invention, each 10mL, every day 3 times.After taking medicine continuously 7 days, dizzy number of times reduces, and appetite strengthens, and after taking medicine 15 days, dizzy symptom obviously reduces, and complexion is gradually red, and mental restoration is normal.Blood routine examination, Hb content becomes the 127g/L after treatment from original 105g/L.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (1)
1. a preparation method for Sugarless type blood-nourishing oral liquid with nine ingredients, is characterized in that, comprises the following steps:
1) Radix Ginseng, Herb Gynostemmae Pentaphylli, Fructus Schisandrae Chinensis, Pericarpium Citri Reticulatae and Radix Angelicae Sinensis is taken, each component with the consumption of parts by weight be Radix Ginseng 55 ~ 100, Herb Gynostemmae Pentaphylli 90 ~ 115, Fructus Schisandrae Chinensis 80 ~ 110, Pericarpium Citri Reticulatae 10 ~ 50 and Radix Angelicae Sinensis 55 ~ 80, each component is ground into coarse powder carry out quick-freezing at-18 ~-30 DEG C after respectively, for subsequent use;
2) Radix Ginseng coarse powder, Herb Gynostemmae Pentaphylli coarse powder and Fructus Schisandrae Chinensis coarse powder are mixed to get first part of coarse powder mixture, volume ratio is to described first part coarse powder mixture in add ethanol that concentration of volume percent be 65 ~ 75% at 1: 8 ~ 1: 15 by weight, after flooding described first part of coarse powder mixture 22 ~ 26h, with 2 ~ 4mL/min percolation, collect percolate to 2000 ~ 2400ml, obtain the first coarse powder percolate and first part of medicinal residues, for subsequent use;
3) Pericarpium Citri Reticulatae coarse powder and Radix Angelicae Sinensis coarse powder are mixed to get second part of coarse powder mixture, volume ratio is to described second part coarse powder mixture in add ethanol that concentration of volume percent be 50 ~ 60% at 1: 8 ~ 1: 15 by weight, after flooding described second part of coarse powder mixture 22 ~ 26h, with 2 ~ 4mL/min percolation, collect percolate to 800 ~ 900ml, obtain the second coarse powder percolate and second part of medicinal residues, for subsequent use;
4) after described first coarse powder percolate and the second coarse powder percolate are merged, be concentrated into the clear paste that relative density is 1.05 ~ 1.10 at temperature 75 ~ 85 DEG C of decompression recycling ethanols, cold preservation 20 ~ 30 hours, get supernatant, filter, the clear paste that relative density is 1.12 ~ 1.20 is evaporated to temperature 75 ~ 85 DEG C, for subsequent use;
5) Radix Astragali is taken, the Rhizoma Atractylodis Macrocephalae, Fructus Crataegi and Radix Glycyrrhizae, each component with the consumption of parts by weight for the Radix Astragali 80 ~ 110, the Rhizoma Atractylodis Macrocephalae 30 ~ 70, Fructus Crataegi 30 ~ 80 and Radix Glycyrrhizae 15 ~ 40, and by the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Fructus Crataegi, Radix Glycyrrhizae and described first part of medicinal residues and described second part of medicinal residues are mixed to get medicinal mixture, afterwards, add water in described medicinal mixture by 6 ~ 10 times of weight, carry out first time decoction, decocting time is 2 ~ 3h for the first time, filtration obtains the first decocting liquid, carry out second time again to decoct, second time decocting time is 1 ~ 2h, filtration obtains the second decocting liquid, merge described first decocting liquid and described second decocting liquid, leave standstill 20 ~ 30h, filter, gained filtrate is evaporated to temperature 75 ~ 85 DEG C the secondary clear paste that relative density is 1.12 ~ 1.20, for subsequent use,
6) secondary clear paste is processed: be to described secondary clear paste in add ethanol that concentration of volume percent be 50 ~ 70% at 1: 2 ~ 1: 4 by volume, convention stir 5 ~ 10min, leave standstill 24h, separated secondary supernatant and secondary lower sediment thing, after getting secondary supernatant recovery ethanol, add a described clear paste, be evaporated at temperature 75-85 DEG C three clear paste that relative density is 1.12 ~ 1.20;
7) by described three clear paste mass percent concentrations be 40% sodium hydroxide solution adjust pH to 6.0 ~ 7.0, leave standstill 24h, filter to get filtrate, in described filtrate, add sweeting agent 10 ~ 400g and ethyl hydroxybenzoate 0.5 ~ 1g, add water and be mixed with 1000ml, stir evenly, fill, sterilizing, packaging, inspection, obtains Sugarless type blood-nourishing oral liquid with nine ingredients; Described sweeting agent is a kind of in stevioside, aspartame, cyclamate, glycyrrhizin, mannitol and sorbitol or the compositions being greater than more than one;
Wherein, described step 4), 5), 6) in relate to the mensuration of clear paste relative density, it measures temperature and is 70 DEG C.
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| CN106362005A (en) * | 2016-10-26 | 2017-02-01 | 苏州华葆药业股份有限公司 | Sugar-free anti-ageing oral liquid and preparing and taking method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1883593A (en) * | 2006-05-22 | 2006-12-27 | 韦金育 | Blood-nourishing oral liquid with nine ingredients |
| CN1899552A (en) * | 2006-07-13 | 2007-01-24 | 广东化州中药厂制药有限公司 | Sugar-free type red tangerine peel oral liquor for treating productive cough |
| CN103041079A (en) * | 2012-12-21 | 2013-04-17 | 恒拓集团广西圣康制药有限公司 | Preparation method of sugar-free Masu anti-cough compound preparation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1883593A (en) * | 2006-05-22 | 2006-12-27 | 韦金育 | Blood-nourishing oral liquid with nine ingredients |
| CN1899552A (en) * | 2006-07-13 | 2007-01-24 | 广东化州中药厂制药有限公司 | Sugar-free type red tangerine peel oral liquor for treating productive cough |
| CN103041079A (en) * | 2012-12-21 | 2013-04-17 | 恒拓集团广西圣康制药有限公司 | Preparation method of sugar-free Masu anti-cough compound preparation |
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Address after: 530023 No. 8-1, Kunlun Avenue, Nanning, the Guangxi Zhuang Autonomous Region Patentee after: Guangxi Baiyun Mountain Ying Kang Pharmaceutical Co., Ltd. Address before: 530023 No. 193, Gang Gang Road, the Guangxi Zhuang Autonomous Region, Nanning Patentee before: Guangxi Yingkang Pharmaceutical Co., Ltd. |