CN103071028A - Traditional Chinese medicinal composition for treating anaphylactoid purpura - Google Patents
Traditional Chinese medicinal composition for treating anaphylactoid purpura Download PDFInfo
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- CN103071028A CN103071028A CN2013100653268A CN201310065326A CN103071028A CN 103071028 A CN103071028 A CN 103071028A CN 2013100653268 A CN2013100653268 A CN 2013100653268A CN 201310065326 A CN201310065326 A CN 201310065326A CN 103071028 A CN103071028 A CN 103071028A
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Abstract
The invention discloses a traditional Chinese medicinal composition for treating anaphylactoid purpura, which consists of the following ingredients according to a certain weight ratio: starwort roots, Chinese angelica, radix scutellariae, rhizoma anemarrhenae, red paeony roots, cortex dictamni, roots of kudzu vines, rhizoma atractylodis, radix saposhnikoviae, poria cocos, rhizoma alismatis, cimicifugae foetidae, sophora flavescens, codonopsis pilosula, unprocessed rehmannia roots, licorice roots northwest origin and panax notoginseng powder. The traditional Chinese medicinal composition achieves the effects of removing heat to cool blood, promoting blood circulation to stop bleeding, dispelling wind to relieve internal heat and regulating vital energy to dredge collaterals, and can be effectively used for treating the anaphylactoid purpura.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for the treatment of anaphylactoid purpura.
Background technology
Anaphylactoid purpura (allergicpurpura, AP) belong to autoimmune disease, that body is to some sensitizer generation allergy, cause widely polyangitis, small artery and capillary permeability, fragility are increased, cause hemorrhage, the edema of subcutaneous tissue, mucosa and internal organs.Involve skin and mucosa more, also can involve gastrointestinal tract, joint, kidney and nervous system etc.Clinical manifestation is that the skin purpura is the symmetry distribution, and is common with lower limb, often occurs in batches, can see simultaneously the new and old ecchymosis that differs.Purpura also can be simultaneously with vasodilation, and the joint is migration pain, redness, abdominal pain diarrhea, and vomiting is had blood in stool, and is caused kidney damage, hematuria, albuminuria occur, can involve nervous system when serious, headache occurs, faints from fear, even cranial nerve paralysis etc.Chinese medicine is said without anaphylactoid purpura one, belongs to Chinese medicine " blood disorder " category, comprises " hematohidrosis ", " rash ", " hemorrhagic disease with purpura ", " purpura ", " arthromyodynia ", " stomachache ", " hematuria ", " having blood in stool " etc.The cause of disease is evil for experiencing wind heat poison, retention of damp-heat in the interior, and the hot and suffocating skin of pyretic toxicity is fought mutually with QI and blood, and the heat in blood blood network of burning, so that escape of blood from meridians overflow in skin, stay and amass in subcutaneous and send out.At present, doctor trained in Western medicine is also used immunosuppressant except adopting antiallergic, and side effect is large, easily recurrence.Use the Chinese medicine primary disease to have unique science practical value, adopt differentiation of tcm can fundamentally nurse one's health patient's yin and yang imbalance state, accomplish whole conditioning and personalized medication, consolidating curative effect, alleviate the toxic and side effects aspect and have obvious advantage, the clinical effect of being satisfied with that obtained.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition has determined curative effect for the treatment anaphylactoid purpura, has no side effect, and is difficult for the characteristics of recurrence.
The present invention selects Radix Stellariae, Radix Angelicae Sinensis, Radix Scutellariae, the Rhizoma Anemarrhenae, Radix Paeoniae Rubra, Cortex Dictamni, Radix Puerariae, Rhizoma Atractylodis, Radix Saposhnikoviae, Poria, Rhizoma Alismatis, Rhizoma Cimicifugae, Radix Sophorae Flavescentis, Radix Codonopsis, Radix Rehmanniae, Radix Glycyrrhizae, Radix Notoginseng powder to make up, with these drug regimens so that each efficacy of drugs produces synergism, make it to have clearing away heat and cooling blood, promoting blood circulation and hemostasis, the detoxifcation of dispeling the wind, the effect of regulating qi and dredging collateral, thus anaphylactoid purpura can effectively be treated.
The effect of Chinese medicine of the present invention:
Wherein:
Radix Stellariae: be the dry root of pinkwort Radix Stellariae Stellaria dichotoma L. var. lanceolata Bge..Nature and flavor are sweet, are slightly cold.Return liver, stomach warp.Effect: clearing away heat and cooling blood.
Radix Angelicae Sinensis: be the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.Nature and flavor are sweet, hot, bitter, temperature.Return liver, the heart, spleen channel.Effect: enrich blood, invigorate blood circulation, menstruction regulating and pain relieving is moisturized laxation.
Radix Scutellariae: be the dry root of labiate Radix Scutellariae Scutellaria baicalensis Georgi.Nature and flavor are bitter, and are cold.Return lung, gallbladder, spleen, stomach, large intestine, small intestine meridian.Effect: heat clearing and damp drying, eliminating fire and detoxication, hemostasis.Radix Scutellariae can react by Immunosuppression, especially to anaphylaxis (anaphylaxis) effect significantly.The fibrin of baicalin energy anticoagulant, anticoagulation, enzyme induction anticoagulant produces.
The Rhizoma Anemarrhenae: be the dry rhizome of monocotyledon Liliaceae Liliaceae Rhizoma Anemarrhenae Anemarrhena asphodeloidesBge..Nature and flavor are bitter, sweet, and are cold.Return lung, stomach, kidney channel.Effect: clearing away heat-fire, promote the production of body fluid and moisturize.
Radix Paeoniae Rubra: be the dry root of ranunculaceae plant Radix Paeoniae Paeonia lactiflora Pall. or river Radix Paeoniae Rubra Paeonia veitchii Lynch.Nature and flavor acid, bitter, cold.Enter liver, spleen channel.Effect: clearing away heat and cooling blood, eliminating stasis to stop pain." the southern regions of the Yunnan Province book on Chinese herbal medicine ": the purgation of spleen excess fire, sending down the abnormal ascending QI, promoting the circulation of blood, removing blood stasis with potent drugs, loose clot ends stomachache, moves back heat in blood, attacks the carbuncle skin ulcer, controls mange.
Cortex Dictamni: be the dry root bark of rutaceae shaggy-fruited dittany Dictamnus dasycarpus Turcz..Nature and flavor are bitter, salty, and are cold.Return spleen, lung, small intestinal, stomach, urinary bladder channel.Effect: heat clearing and damp drying; Dispelling wind for relieving itching; Detoxifcation.Cortex Dictamni extract can effectively resist I, type Ⅳ allergy, has good anti-allergic effects.
Radix Puerariae: be the dry root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi.Nature and flavor are sweet, hot, cold.Enter spleen, stomach warp.Effect: induce sweat and bring down a fever, promote the production of body fluid, rash, yang invigorating antidiarrheal.
Rhizoma Atractylodis: be the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. Atractylodes lancea (Thunb.) DC. or Atractylis chinensis Atractylodes chinensis (DC.) Koidz..Nature and flavor are hot, bitter, temperature.Return spleen, stomach, Liver Channel.Effect: drying damp and strengthening spleen, expelling wind and cold makes eye bright." beautiful Chinese catalpa medicine solution ": dry native diuretic, let out the drink expectorant, clots absorbing, dissipating depression of QI goes Lou, changes addiction, and except disease, reason acid regurgitation removing the necrotic tissue is warded off the mountains and rivers communicable subtropical diseases, and the flaccidity that returns muscles and bones is soft, the excessive muddiness of urinating clearly.
Radix Saposhnikoviae: be the dry root of umbelliferae Saposhnikovia divaricata Saposhnikovia divaricata (Turcz.) Schischk..Nature and flavor are hot, sweet, tepor.Return bladder, lung, spleen, Liver Channel.Effect: expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.Radix Saposhnikoviae has anti-allergic effects and refrigeration function.
Poria: be the dry sclerotia of On Polyporaceae Poria Poria cocos (Schw.) Wolf.Nature and flavor are sweet, light, and are flat.GUIXIN, lung, spleen, kidney channel.Effect: promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.
Rhizoma Alismatis: be the dry tuber of Alismataceae (Alismataceae) plant Rhizoma Alismatis Alisma orientale (Samuels) Juzep..Nature and flavor are sweet, light, and are cold.Return kidney, urinary bladder channel.Effect: promoting diuresis to eliminate damp pathogen; It is treating stranguria to expel the heat-evil.
Rhizoma Cimicifugae: be the dry rhizome of ranunculaceae plant C.heracleifolia Cimicifuga heracleifolia Kom., Cimicifuga Dahurica Cimicifuga dahurica (Turcz.) Maxim. or Rhizoma Cimicifugae Cimicifuga foetida L..Nature and flavor are hot, little sweet, are slightly cold.Return lung, spleen, stomach, large intestine channel.Effect: deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.Shorten to a certain extent clotting time, obvious anastalsis is arranged." detailed outline ": the speckle removing rash, clots absorbing blood is controlled sun and is fallen into dizzy fortune, the empty pain of the breast side of body is heavy behind the chronic diarrhea dysentery, lose turbid, leukorrhagia, metrorrhagia, stranguria with blood, hematochezia, impotence cold foot.
Radix Sophorae Flavescentis: be the dry root of leguminous plant Radix Sophorae Flavescentis Sophora flavescens Ait..Nature and flavor are bitter, and are cold.Return liver, kidney, large intestine, small intestinal, bladder, heart channel.Effect: heat clearing and damp drying, diuresis.Matrine can reduce the release of Anaphylactic mediator, is immunosuppressant, and anti-allergic effects is arranged.
Radix Codonopsis: be the dry root of Campanulaceae Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., element flower Radix Codonopsis Codonopsis pilosula Nannf.var. modesta (Nannf.) L. T. Shen or radix codonpsis tangshen Codonopsis tangshen Oliv..Sweet, the little acid of nature and flavor, flat.Return spleen, lung meridian.Effect: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.Radix Codonopsis has the enhancing human body immunity function.
Radix Rehmanniae: be the root of dicotyledon medicine scrophulariaceae rehmannia glutinosa plant or bosom celebrating Radix Rehmanniae, Radix Rehmanniae slowly cured to eighty per cant do.Nature and flavor are sweet, bitter, cold.Enter the heart, liver, kidney channel.Clearing away heat and cooling blood, the YIN nourishing of promoting the production of body fluid.The existing anastalsis of Radix Rehmanniae has again blood coagulation resisting function and anti-allergic effects.
Radix Glycyrrhizae: be glycyrrhizic legume Glycyrrhiza uralensis Fisch., the dry root and rhizome of Glycyrrhiza inflata Bat. Glycyrrhiza Inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza Glabra L..Nature and flavor are sweet, and are flat.GUIXIN, lung, spleen, stomach warp.Effect: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Radix Notoginseng powder: be plant Radix Notoginseng (formal name used at school: rhizome goods Panax pseudo-ginseng).Sweet, the little hardship of nature and flavor, temperature.Enter liver, stomach, large intestine channel.Effect: hemostasis, dissipating blood stasis, analgesic therapy.The Radix Notoginseng function is enriched blood, and blood stasis removing decreases, and the hemostasis nosebleed can be led to and can be mended, and effect is the best, the most precious person in the side's of being medicine.
Medicine material consumption of the present invention is groped to sum up to draw through the inventor in a large number, and each raw material consumption is for all to have preferably curative effect in the following weight parts scope: Radix Stellariae 13-23 part, Radix Angelicae Sinensis 10-20 part, Radix Scutellariae 10-20 part, Rhizoma Anemarrhenae 7-17 part, Radix Paeoniae Rubra 10-20 part, Cortex Dictamni 10-20 part, Radix Puerariae 13-23 part, Rhizoma Atractylodis 13-23 part, Radix Saposhnikoviae 5-15 part, Poria 13-23 part, Rhizoma Alismatis 10-20 part, Rhizoma Cimicifugae 10-20 part, Radix Sophorae Flavescentis 7-17 part, Radix Codonopsis 10-20 part, Radix Rehmanniae 10-20 part, Radix Glycyrrhizae 6-12 part, Radix Notoginseng powder 2-4 part.
Wherein be preferably: 18 parts of Radix Stellariaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Scutellariaes, 12 parts of the Rhizoma Anemarrhenaes, 15 parts of Radix Paeoniae Rubra, 15 parts of Cortex Dictamni, 18 parts of Radix Puerariaes, 18 parts of Rhizoma Atractylodis, 10 parts of Radix Saposhnikoviaes, 18 parts in Poria, 15 parts of Rhizoma Alismatis, 15 parts of Rhizoma Cimicifugaes, 12 parts of Radix Sophorae Flavescentiss, 15 parts of Radix Codonopsis, 15 parts of Radix Rehmanniae, 9 parts of Radix Glycyrrhizae, 3 parts of Radix Notoginseng powder.
Medicine of the present invention can adopt the conventional preparation technology of Chinese medicine preparation, can be made into said dosage form on any pharmaceutics, such as pill, powder, tablet, capsule, granule, syrup, oral liquid etc.For example these crude drug grind into fine powder mix homogeneously can be made powder takes after mixing it with water; Can use decocting, get after filtration filtrate, add antiseptic and make oral liquid; Also can directly take decoction in case of necessity.
Medicine of the present invention has clearing away heat and cooling blood, promoting blood circulation and hemostasis, the detoxifcation of dispeling the wind, the effects such as regulating qi and dredging collateral, and determined curative effect has no side effect, and is difficult for recurrence, according to clinical 100 routine patients are observed statistics, use medicine total effective rate course for the treatment of total effective rate 87%, two course for the treatment of 96% of the present invention.
The specific embodiment
Embodiment one, 13 parts of Radix Stellariaes, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Scutellariaes, 7 parts of the Rhizoma Anemarrhenaes, 10 parts of Radix Paeoniae Rubra, 10 parts of Cortex Dictamni, 13 parts of Radix Puerariaes, 13 parts of Rhizoma Atractylodis, 5 parts of Radix Saposhnikoviaes, 13 parts in Poria, 10 parts of Rhizoma Alismatis, 10 parts of Rhizoma Cimicifugaes, 7 parts of Radix Sophorae Flavescentiss, 10 parts of Radix Codonopsis, 10 parts of Radix Rehmanniae, 6 parts of Radix Glycyrrhizae, 2 parts of Radix Notoginseng powder.
Embodiment two, 18 parts of Radix Stellariaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Scutellariaes, 12 parts of the Rhizoma Anemarrhenaes, 15 parts of Radix Paeoniae Rubra, 15 parts of Cortex Dictamni, 18 parts of Radix Puerariaes, 18 parts of Rhizoma Atractylodis, 10 parts of Radix Saposhnikoviaes, 18 parts in Poria, 15 parts of Rhizoma Alismatis, 15 parts of Rhizoma Cimicifugaes, 12 parts of Radix Sophorae Flavescentiss, 15 parts of Radix Codonopsis, 15 parts of Radix Rehmanniae, 9 parts of Radix Glycyrrhizae, 3 parts of Radix Notoginseng powder.
Embodiment three, 23 parts of Radix Stellariaes, 20 parts of Radix Angelicae Sinensis, 20 parts of Radix Scutellariaes, 17 parts of the Rhizoma Anemarrhenaes, 20 parts of Radix Paeoniae Rubra, 20 parts of Cortex Dictamni, 23 parts of Radix Puerariaes, 23 parts of Rhizoma Atractylodis, 15 parts of Radix Saposhnikoviaes, 23 parts in Poria, 20 parts of Rhizoma Alismatis, 20 parts of Rhizoma Cimicifugaes, 17 parts of Radix Sophorae Flavescentiss, 20 parts of Radix Codonopsis, 20 parts of Radix Rehmanniae, 12 parts of Radix Glycyrrhizae, 4 parts of Radix Notoginseng powder.
The below is the clinical statistics data that the patient uses medicine of the present invention:
One, physical data
Accept patient's totally 100 examples for medical treatment, male's 56 examples wherein, women's 44 examples, M-F 1.3:1,38 years old mean age.
Two, tcm diagnosis standard:
1, allergic constitution or have more sure anaphylactogen to cause is arranged.
2, the visible point-like of whole body or extremity or speckle shape are hemorrhage, do not exceed skin, repeatedly outbreak.Or hemorrhage speckle slightly exceeds skin, and color is scarlet or dark red, and little itching can accompany the diseases such as stomachache or joint aches.
2, can accompany low grade fever, bleeding from the gum, epistaxis, menorrhagia.Headache can appear in severe patient, and stupor is had blood in stool hematuria.
3, platelet count, platelet function and clotting time are all normal, and capillary fragility test is positive.
4, histological examination: can see even one allergic angiitis in get involved position skin or the tissue, PCV has a large amount of leukocyte infiltrations, and the downright bad and erythrocyte of fiber-like oozes out outside the blood vessel, and blood vessel wall can active property necrosis, epithelial cell proliferation.
5, the vasculitis that other diseases causes except, cryoglobulin syndrome, optimum high globulin purpura, annular purpura annularis telangiectodes, pigmentation purpura lichenoid dermatitis etc.
Three, Therapeutic Method:
According to drug weight proportioning of the present invention, weighting raw materials (daily dose) is made powder with these crude drug grind into fine powder mix homogeneously and is taken after mixing it with water, and sooner or later services once, and 15 is a course for the treatment of.
Four, efficacy assessment standard:
1, cure: the purple point of purpura and General Symptoms disappear.
2, take a turn for the better: the cyanosis of the skin speckle obviously reduces, and General Symptoms alleviates.
3, do not heal: cyanosis of the skin speckle, General Symptoms are all unchanged.
Five, therapeutic outcome statistics
Wherein: total effective rate=cure rate+improvement rate
Model case and curative effect:
Case one, gold certain, the man, at 5 years old age, skin purpura before two days begins to appear at the bilateral shank, the petechia of not fading of around the ankle joint, differ in size, be aubergine, pressing is sometimes also with urticaria.The patient takes Chinese medicine of the present invention after course for the treatment of, and the purple point of purpura disappears, and cures.
Case two, week certain, the woman, 16 years old age, the bimester of suffering from anaphylactoid purpura more than, the petechia appears in patient's upper limb, chest and back, even large stretch of ecchymosis and courageous and upright blister are arranged.Ankle joint, knee joint congestion and swelling pain can not be walked about.The patient takes Chinese medicine of the present invention after two courses for the treatment of, and the purple point of purpura and General Symptoms disappear, and cure.Follow up a case by regular visits to: drug withdrawal 1 year has no recurrence.
Case three, Wu, the man, 45 years old age, suffered from anaphylactoid purpura more than 2 years, the blood point appears in extremity, and to the body development, weak all over, listless gradually, it is painful knee joint often to occur, stomachache, hematuria.The patient takes Chinese medicine of the present invention after two courses for the treatment of, and the purple point of purpura and General Symptoms disappear, and cure.Follow up a case by regular visits to: drug withdrawal 1 year has no recurrence.
Claims (2)
1. Chinese medicine composition for the treatment of anaphylactoid purpura, it is characterized in that this Chinese medicine composition is the ingredients by following weight portion: Radix Stellariae 13-23 part, Radix Angelicae Sinensis 10-20 part, Radix Scutellariae 10-20 part, Rhizoma Anemarrhenae 7-17 part, Radix Paeoniae Rubra 10-20 part, Cortex Dictamni 10-20 part, Radix Puerariae 13-23 part, Rhizoma Atractylodis 13-23 part, Radix Saposhnikoviae 5-15 part, Poria 13-23 part, Rhizoma Alismatis 10-20 part, Rhizoma Cimicifugae 10-20 part, Radix Sophorae Flavescentis 7-17 part, Radix Codonopsis 10-20 part, Radix Rehmanniae 10-20 part, Radix Glycyrrhizae 6-12 part, Radix Notoginseng powder 2-4 part.
2. according to the Chinese medicine composition of claims 1 described treatment anaphylactoid purpura, it is characterized in that, by the ingredients of following weight portion: 18 parts of Radix Stellariaes, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Scutellariaes, 12 parts of the Rhizoma Anemarrhenaes, 15 parts of Radix Paeoniae Rubra, 15 parts of Cortex Dictamni, 18 parts of Radix Puerariaes, 18 parts of Rhizoma Atractylodis, 10 parts of Radix Saposhnikoviaes, 18 parts in Poria, 15 parts of Rhizoma Alismatis, 15 parts of Rhizoma Cimicifugaes, 12 parts of Radix Sophorae Flavescentiss, 15 parts of Radix Codonopsis, 15 parts of Radix Rehmanniae, 9 parts of Radix Glycyrrhizae, 3 parts of Radix Notoginseng powder.
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Cited By (5)
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| CN104274614A (en) * | 2014-10-11 | 2015-01-14 | 李小群 | Drug for treating allergic purpura disease |
| CN104510942A (en) * | 2015-01-14 | 2015-04-15 | 刘小芳 | Traditional Chinese medicine for treating allergic purpura |
| CN104906295A (en) * | 2015-06-09 | 2015-09-16 | 王婷婷 | Traditional Chinese medicine combination for treating wind-heat injuring collateral type purpura |
| CN104971231A (en) * | 2015-07-09 | 2015-10-14 | 宋永欣 | Traditional Chinese medicine composition for treating anaphylactoid purpura and preparation method of traditional Chinese medicine composition |
| CN105232758A (en) * | 2015-10-10 | 2016-01-13 | 临沂草之美医药科技有限公司 | Solar dermatitis treating pharmaceutical composition and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104274614A (en) * | 2014-10-11 | 2015-01-14 | 李小群 | Drug for treating allergic purpura disease |
| CN104510942A (en) * | 2015-01-14 | 2015-04-15 | 刘小芳 | Traditional Chinese medicine for treating allergic purpura |
| CN104906295A (en) * | 2015-06-09 | 2015-09-16 | 王婷婷 | Traditional Chinese medicine combination for treating wind-heat injuring collateral type purpura |
| CN104971231A (en) * | 2015-07-09 | 2015-10-14 | 宋永欣 | Traditional Chinese medicine composition for treating anaphylactoid purpura and preparation method of traditional Chinese medicine composition |
| CN105232758A (en) * | 2015-10-10 | 2016-01-13 | 临沂草之美医药科技有限公司 | Solar dermatitis treating pharmaceutical composition and preparation method thereof |
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Application publication date: 20130501 |