CN105232758A - Solar dermatitis treating pharmaceutical composition and preparation method thereof - Google Patents

Abstract

The invention discloses a solar dermatitis treating pharmaceutical composition and a preparation method thereof and belongs to the technical field of traditional Chinese medicine. The pharmaceutical composition is prepared from suberect spatholobus stem, dried rehmannia root, chrysanthemum, dandelion, densefruit pittany root-bark, heartleaf gouttuymia gerb, radix paeoniae rubra, goneysuckle flower, cape jasmine fruit, rhizome or root of incised notopterygium, baical skullcap root, szechuan lovage rhizome, dahuricae angelica root, fineleaf schizonepeta herb, divaricate saposhnikovia root, light yellow sophora root, radix scrophulariae and radix glycyrrhiza. The pharmaceutical composition has efficacy of clearing heat and detoxicating, curing skin and protecting skin against allergy, dispersing stagnation and dredging the collaterals, reducing inflammation and relieving itching, clearing damp and rheumatism, and further has the advantages of good efficacy, low side effect, low recurrence rate, easiness in promotion and the like.

Description

A kind of pharmaceutical composition for the treatment of solar dermatitis and preparation method thereof

Technical field

The invention belongs to technical field of Chinese medicines, particularly relate to a kind of pharmaceutical composition for the treatment of solar dermatitis and preparation method thereof.

Background technology

Solar dermatitis is a kind of dermatosis relevant to daylight, namely usually said sunburn.It is a kind of anaphylaxis dermatoses being caused by light, betide exposure portion.Principle is: normal skin makes intradermal various kinds of cell discharge the inflammatory mediators such as histamine, 5-hydroxy tryptamine, kassinin kinin through ultraviolet radiation, makes intradermal vasodilation, and permeability increases.Shine the action spectrum mainly UVB of primary disease in red-letter day spring and summer, normal skin makes intradermal various kinds of cell discharge the inflammatory mediators such as histamine, 5-hydroxy tryptamine, kassinin kinin through ultraviolet radiation, makes intradermal vasodilation, permeability increase.The action spectrum mainly UVB of primary disease, normal skin makes intradermal various kinds of cell discharge the inflammatory mediators such as histamine, 5-hydroxy tryptamine, kassinin kinin through ultraviolet radiation, makes intradermal vasodilation, permeability increase.The action spectrum mainly UVB of primary disease, normal skin makes intradermal various kinds of cell discharge the inflammatory mediators such as histamine, 5-hydroxy tryptamine, kassinin kinin through ultraviolet radiation, makes intradermal vasodilation, permeability increase.The action spectrum mainly UVB of primary disease, normal skin makes intradermal various kinds of cell discharge the inflammatory mediators such as histamine, 5-hydroxy tryptamine, kassinin kinin through ultraviolet radiation, makes intradermal vasodilation, permeability increase.The action spectrum mainly UVB of primary disease, normal skin makes intradermal various kinds of cell discharge the inflammatory mediators such as histamine, 5-hydroxy tryptamine, kassinin kinin through ultraviolet radiation, makes intradermal vasodilation, permeability increase.After more than a few hours to ten hour, occur the erythra such as erythema, pimple, welt sample or blister in exposure portion, cutaneous lesion has burn feeling, gargalesthesia or twinge, often affects sleep.Can fully recover in the lighter 2-3 days, severe patient could recover for about one week.Erythema colour-darkening subsequently, desquamation or the pigmentation left in various degree.Few patients can with conjunctival congestion, blepharoedema.The wide person of Exposure to Sunlight area, can cause class cold symptoms, as heating, fear of cold, headache, weak, nauseating and general malaise etc., even cardiopalmus, shock.

The pathogenic factor of solar dermatitis has a lot, is not only to be irradiated by sunlight to cause.Except sunlight irradiates, food, medicine factor also can cause dermatitis.As food or medicines such as Herba Spinaciae, Brassica campestris L Herba Capsellae, Amaranthus mangostanus L., Herba Apii graveolentis, Fructus Solani melongenae, Rhizoma Solani tuber osi, Flos Chrysanthemi, the Radixs Angelicae Dahuricae.After edible, the photosensitive material inside these foods, medicine will be put aside in vivo, and when reaching finite concentration, the skin of face, human body exposed position, hands, foot can cause dysbolismus through the direct projection of sunlight and bring out dermatitis.Some chemical & blended fabric, absorbing sweat permeability is poor, and the weak medicated clothing of reflection action also easily causes solar dermatitis.In addition, body constitution is also a very important factor.Chinese medicine think primary disease due to natural endowment not resistance to, raw in heat in blood, feed stimulating food, taste are lacked of proper care, damp and hot interior life, and multiple because of Exposure to Sunlight, pyretic toxicity attacks skin, sends out suddenly.Generally speaking, the white and xerodermatic people of skin than oily skin and the black people of skin more responsive to daylight.

If the drug main Western medicine of current treatment solar dermatitis, the lighter's antihistaminic, severe one or curative effect not good enough person's low-dose Oral glucocorticoid, aspirin or indomethacin.But these medicines are mostly hormone medicine, life-time service, not only certain damage is caused to skin or other organ, and can not from the skin quality of radical change to sun sensitivity.In addition, there is a small amount of Chinese medicine composition for the treatment of solar dermatitis, reaching therapeutic effect in varying degrees, but unsatisfactory.

China applies for a patent 201410113112.8 and discloses a kind of Chinese medicine composition for the treatment of solar dermatitis, this Chinese medicine composition is prepared from by the raw material of following weight portion: Herba Portulacae 10-50 part, Rhizoma Et Radix Notopterygii 10-20 part, Flos Sophorae 5-20 part, Radix Scutellariae 5-15 part, Radix Rehmanniae Preparata 5-10 part, Bulbus Lilii 5-15 part, Flos Lonicerae 5-15 part, Herba Taraxaci 1-10 part, Fructus Lycii 5-15 part, Herba Scutellariae Barbatae 9-15 part, Rhizoma Chuanxiong 9-15 part, Radix Angelicae Dahuricae 5-15 part, berberine 0.2-9 part, Radix Paeoniae Alba 5.5-15 part, Rhizoma Zingiberis 6-9 part, Radix Glycyrrhizae 10-15 part, this Chinese medicine composition has anti-inflammatory and antalgic, effect of activating blood circulation to dissipate blood stasis, but can not prevention and therapy solar dermatitis comprehensively.

Summary of the invention

The technical problem to be solved in the present invention is to provide a kind of pharmaceutical composition for the treatment of solar dermatitis, this pharmaceutical composition has heat-clearing and toxic substances removing, treats skin antiallergic, disperse blood stasis and dredge collateral, anti-inflammatory anti-itch, damp eliminating is except effect of fraud, also have good effect, side effect low, not easily recur and be easy to advantages such as applying, in addition, the present invention also provides corresponding manufacturing process to be made and facilitate easy-to-use preparation under the prerequisite ensureing curative effect by this pharmaceutical composition.

The technical solution used in the present invention is:

Treat a pharmaceutical composition for solar dermatitis, be prepared from by the raw material of following parts by weight:

Caulis Spatholobi 5-15 part, Radix Rehmanniae 10-16 part, Flos Chrysanthemi 4-10 part, Herba Taraxaci 4-10 part, Cortex Dictamni 5-9 part, Herba Houttuyniae 3-6 part, Radix Paeoniae Rubra 8-12 part, Flos Lonicerae 3-9 part, Fructus Gardeniae 4-8 part, Rhizoma Et Radix Notopterygii 4-8 part, Radix Scutellariae 5-17 part, Rhizoma Chuanxiong 9-15 part, Radix Angelicae Dahuricae 4-14 part, Herba Schizonepetae 4-9 part, Radix Saposhnikoviae 4-12 part, Radix Sophorae Flavescentis 5-10 part, Radix Scrophulariae 3-6 part and Radix Glycyrrhizae 8-16 part.

Preferably, described pharmaceutical composition is prepared from by the raw material of following parts by weight:

Caulis Spatholobi 5 parts, Radix Rehmanniae 10 parts, Flos Chrysanthemi 4 parts, Herba Taraxaci 4 parts, Cortex Dictamni 5 parts, Herba Houttuyniae 3 parts, Radix Paeoniae Rubra 8 parts, Flos Lonicerae 3 parts, Fructus Gardeniae 4 parts, Rhizoma Et Radix Notopterygii 4 parts, Radix Scutellariae 5 parts, Rhizoma Chuanxiong 9 parts, the Radix Angelicae Dahuricae 4 parts, Herba Schizonepetae 4 parts, Radix Saposhnikoviae 4 parts, Radix Sophorae Flavescentis 5 parts, Radix Scrophulariae 3 parts and 8 parts, Radix Glycyrrhizae.

Preferably, described pharmaceutical composition is prepared from by the raw material of following parts by weight:

Caulis Spatholobi 15 parts, Radix Rehmanniae 16 parts, Flos Chrysanthemi 10 parts, Herba Taraxaci 10 parts, Cortex Dictamni 9 parts, Herba Houttuyniae 6 parts, Radix Paeoniae Rubra 12 parts, Flos Lonicerae 9 parts, Fructus Gardeniae 8 parts, Rhizoma Et Radix Notopterygii 8 parts, Radix Scutellariae 17 parts, Rhizoma Chuanxiong 15 parts, the Radix Angelicae Dahuricae 14 parts, Herba Schizonepetae 9 parts, Radix Saposhnikoviae 12 parts, Radix Sophorae Flavescentis 10 parts, Radix Scrophulariae 6 parts and 16 parts, Radix Glycyrrhizae.

Preferably, described pharmaceutical composition is prepared from by the raw material of following parts by weight:

Caulis Spatholobi 12 parts, Radix Rehmanniae 14 parts, Flos Chrysanthemi 6 parts, Herba Taraxaci 8 parts, Cortex Dictamni 7 parts, Herba Houttuyniae 5 parts, Radix Paeoniae Rubra 10 parts, Flos Lonicerae 6 parts, Fructus Gardeniae 6 parts, Rhizoma Et Radix Notopterygii 6 parts, Radix Scutellariae 13 parts, Rhizoma Chuanxiong 12 parts, the Radix Angelicae Dahuricae 10 parts, Herba Schizonepetae 6 parts, Radix Saposhnikoviae 10 parts, Radix Sophorae Flavescentis 6 parts, Radix Scrophulariae 4 parts and 14 parts, Radix Glycyrrhizae.

Preferably, described pharmaceutical composition is made into gel ointment, spray or powder.

Accordingly, the preparation method of described pharmaceutical composition comprises following step:

(1): get Caulis Spatholobi, wash away impurity, crushed after being dried, cross 100-140 mesh sieve, adding Caulis Spatholobi coarse powder gross weight 3-6 times amount volume fraction is the ethanol of 75-80%, add the cellulase of Caulis Spatholobi coarse powder total amount 0.8%-1.2% again, lixiviate 1-2 hour at 38-45 DEG C, then at 65-75 DEG C of reflux, extract, 1-2 hour, filters and retains Caulis Spatholobi filtering residue, at filtrate reduced in volume to 50 DEG C, relative density is the extractum of 1.10-1.25, obtains Caulis Spatholobi extract;

(2): get Radix Rehmanniae, Flos Chrysanthemi, Herba Taraxaci, Cortex Dictamni, Herba Houttuyniae, Radix Paeoniae Rubra, Flos Lonicerae, Fructus Gardeniae, Rhizoma Et Radix Notopterygii, Radix Scutellariae, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Schizonepetae, Radix Saposhnikoviae, Radix Sophorae Flavescentis, Radix Scrophulariae and Radix Glycyrrhizae, above-mentioned Chinese crude drug is pulverized, the 4-6 times of concentration adding above-mentioned coarse powder gross weight is the alcoholic solution of 65-75%, reflux, extract, 2-3 time, each 2-4h, filters, decompression filtrate recycling ethanol, cold filtration, washes with water, obtains Chinese medical concrete;

(3): the Chinese medical concrete that Caulis Spatholobi extract step (1) obtained and step (2) obtain mixes, dry, to obtain final product.

Source, the nature and flavor of the present invention's component used, return through and effect:

Caulis Spatholobi: this product is the plant of pulse family Millettia, bitter in the mouth, sweet, warm in nature; Return liver, kidney channel; Enrich blood, invigorate blood circulation, dredging collateral; Relaxing muscles and tendons to promote blood circulation, nourishing blood for regulating menstruation.

Radix Rehmanniae: this product is the rhizome for scrophulariaceae rehmannia glutinosa plant; Sweet-bitter flavor, cold in nature; GUIXIN, liver, kidney channel; Heat clearing away, removing heat from blood, promotes the production of body fluid.

Flos Chrysanthemi: this product is the dry capitulum of feverfew chrysanthemum; Sweet-bitter flavor, cold nature; Return lung, Liver Channel; Loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.

Herba Taraxaci: this product is the dry herb of feverfew Herba Taraxaci; Bitter but sweet flavor, cold in nature; Return liver, stomach warp; Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.

Cortex Dictamni: this product is the dry root bark of rutaceae shaggy-fruited dittany; Bitter in the mouth, cold in nature; Return spleen, stomach, urinary bladder channel;

Heat clearing and damp drying, removing toxic substances of dispeling the wind.

Herba Houttuyniae: this product is the dry aerial parts of saururaceae plant houttuynia cordata; Acrid in the mouth, tepor; Enter liver, lung two warp; Heat-clearing and toxic substances removing, inducing diuresis to remove edema.

Radix Paeoniae Rubra: this product is the dry root of ranunculaceae plant Radix Paeoniae or river Radix Paeoniae Rubra; Bitter in the mouth, cold nature; Return Liver Channel; Clearing away heat and cooling blood, eliminating stasis to stop pain.

Flos Lonicerae: this product is dry flower or the first flower opened of band of caprifoliaceae plant; Sweet in the mouth, cold in nature; Return lung, the heart, stomach warp; Heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treat wind.

Fructus Gardeniae: this product is the fruit of Maguireothamnus speciosus Fructus Gardeniae; Bitter in the mouth, cold in nature; GUIXIN, lung, tri-jiao channel; Clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, reducing swelling and alleviating pain.

Rhizoma Et Radix Notopterygii: this product is dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii (back of the body wing celery) or Radix et Rhizoma Notopterygii; Acrid in the mouth, hardship, warm in nature; Return bladder, kidney channel; Cold expelling, dispels the wind, dehumidifying, pain relieving.

Radix Scutellariae: this product is the dry root of labiate Radix Scutellariae; Bitter in the mouth, cold in nature; Return lung, gallbladder, spleen, large intestine, small intestine meridian; Have heat clearing and damp drying, removing heat from blood is antiabortive, detoxicating functions.

Rhizoma Chuanxiong: this product is the dry rhizome of samphire Rhizoma Chuanxiong; Acrid in the mouth, warm in nature; Return liver, gallbladder, pericardium channel; Blood-activating and qi-promoting, wind-expelling pain-stopping.

The Radix Angelicae Dahuricae: this product is the dry root of the umbellate form section plant Radix Angelicae Dahuricae or Radix angelicae dahuricae; Acrid in the mouth, warm in nature; Return stomach, large intestine, lung meridian; Loose wind dehumidifying, understand things pain-stopping, detumescence and apocenosis.

Herba Schizonepetae: this product is the dry aerial parts of labiate Herba Schizonepetae; Acrid in the mouth, slightly warm in nature; Return lung, Liver Channel; Induce sweat loose wind, rash.

Radix Saposhnikoviae: this product is the dry root of umbelliferae Saposhnikovia divaricata; Acrid in the mouth, sweet, warm in nature; Return bladder, liver, spleen channel; Inducing diaphoresis to dispel wind, victory is wet, relieving convulsion.

Radix Sophorae Flavescentis: this product is the dry root of leguminous plant Radix Sophorae Flavescentis; Bitter in the mouth, cold in nature; GUIXIN, liver, stomach, large intestine, urinary bladder channel; Heat clearing and damp drying, parasite killing, diuresis.

Radix Scrophulariae: this product is the root of goatweed Radix Scrophulariae; Sweet in the mouth, hardship, salty, cold nature; Enter lung, kidney channel; Clearing away heat and cooling blood, nourishing YIN to lower pathogenic fire, detoxicating and resolving stagnation of pathogens.

Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume; Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.

Compared with prior art, the present invention has following technical advantage:

1, pharmaceutical composition of the present invention is compared with the medicine of other treatment solar dermatitis, at heat-clearing and toxic substances removing, treats skin antiallergic, disperse blood stasis and dredge collateral, anti-inflammatory anti-itch, damp eliminating except in fraud, has more significant effect.

2, compared with the chemotherapeutic agent of Current therapeutic solar dermatitis, pharmaceutical composition of the present invention is natural pure Chinese medicinal preparation, and untoward reaction and side effect significantly reduce, and pharmaceutical composition effect of the present invention is comprehensive, and medication effect is better.

3, pharmaceutical composition of the present invention also has that compatibility science, preparation technology are simple, good effect, side effect are low, not easily recur and be easy to advantages such as applying.

Detailed description of the invention

It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.

embodiment 1:

Raw material is taken: Caulis Spatholobi 5 parts, Radix Rehmanniae 10 parts, Flos Chrysanthemi 4 parts, Herba Taraxaci 4 parts, Cortex Dictamni 5 parts, Herba Houttuyniae 3 parts, Radix Paeoniae Rubra 8 parts, Flos Lonicerae 3 parts, Fructus Gardeniae 4 parts, Rhizoma Et Radix Notopterygii 4 parts, Radix Scutellariae 5 parts, Rhizoma Chuanxiong 9 parts, the Radix Angelicae Dahuricae 4 parts, Herba Schizonepetae 4 parts, Radix Saposhnikoviae 4 parts, Radix Sophorae Flavescentis 5 parts, Radix Scrophulariae 3 parts and 8 parts, Radix Glycyrrhizae by following parts by weight.

Preparation method is as follows:

(1): get Caulis Spatholobi, wash away impurity, crushed after being dried, cross 100 mesh sieves, adding Caulis Spatholobi coarse powder gross weight 3 times amount volume fraction is the ethanol of 75%, add the cellulase of Caulis Spatholobi coarse powder total amount 0.8% again, lixiviate 1 hour at 38 DEG C, then 65 DEG C of reflux, extract, 1 hour, filters and retains Caulis Spatholobi filtering residue, at filtrate reduced in volume to 50 DEG C, relative density is the extractum of 1.10, obtains Caulis Spatholobi extract;

(2): get Radix Rehmanniae, Flos Chrysanthemi, Herba Taraxaci, Cortex Dictamni, Herba Houttuyniae, Radix Paeoniae Rubra, Flos Lonicerae, Fructus Gardeniae, Rhizoma Et Radix Notopterygii, Radix Scutellariae, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Schizonepetae, Radix Saposhnikoviae, Radix Sophorae Flavescentis, Radix Scrophulariae and Radix Glycyrrhizae, above-mentioned Chinese crude drug is pulverized, the 4-6 times of concentration adding above-mentioned coarse powder gross weight is the alcoholic solution of 65%, reflux, extract, 2 times, each 2h, filters, decompression filtrate recycling ethanol, cold filtration, washes with water, obtains Chinese medical concrete;

(3): the Chinese medical concrete that Caulis Spatholobi extract step (1) obtained and step (2) obtain mixes, dry, add corresponding adjuvant, make gel ointment.

embodiment 2:

Raw material is taken: Caulis Spatholobi 15 parts, Radix Rehmanniae 16 parts, Flos Chrysanthemi 10 parts, Herba Taraxaci 10 parts, Cortex Dictamni 9 parts, Herba Houttuyniae 6 parts, Radix Paeoniae Rubra 12 parts, Flos Lonicerae 9 parts, Fructus Gardeniae 8 parts, Rhizoma Et Radix Notopterygii 8 parts, Radix Scutellariae 17 parts, Rhizoma Chuanxiong 15 parts, the Radix Angelicae Dahuricae 14 parts, Herba Schizonepetae 9 parts, Radix Saposhnikoviae 12 parts, Radix Sophorae Flavescentis 10 parts, Radix Scrophulariae 6 parts and 16 parts, Radix Glycyrrhizae by following parts by weight.

Preparation method is as follows:

(1): get Caulis Spatholobi, wash away impurity, crushed after being dried, cross 120 mesh sieves, adding Caulis Spatholobi coarse powder gross weight 4 times amount volume fraction is the ethanol of 80%, add the cellulase of Caulis Spatholobi coarse powder total amount 1.0% again, lixiviate 1 hour at 40 DEG C, then 70 DEG C of reflux, extract, 1 hour, filters and retains Caulis Spatholobi filtering residue, at filtrate reduced in volume to 50 DEG C, relative density is the extractum of 1.20, obtains Caulis Spatholobi extract;

(2): get Radix Rehmanniae, Flos Chrysanthemi, Herba Taraxaci, Cortex Dictamni, Herba Houttuyniae, Radix Paeoniae Rubra, Flos Lonicerae, Fructus Gardeniae, Rhizoma Et Radix Notopterygii, Radix Scutellariae, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Schizonepetae, Radix Saposhnikoviae, Radix Sophorae Flavescentis, Radix Scrophulariae and Radix Glycyrrhizae, above-mentioned Chinese crude drug is pulverized, the 5 times of concentration adding above-mentioned coarse powder gross weight are the alcoholic solution of 70%, reflux, extract, 2 times, each 3h, filters, decompression filtrate recycling ethanol, cold filtration, washes with water, obtains Chinese medical concrete;

(3): the Chinese medical concrete that Caulis Spatholobi extract step (1) obtained and step (2) obtain mixes, dry, add corresponding adjuvant, make spray.

embodiment 3:

Raw material is taken: Caulis Spatholobi 12 parts, Radix Rehmanniae 14 parts, Flos Chrysanthemi 6 parts, Herba Taraxaci 8 parts, Cortex Dictamni 7 parts, Herba Houttuyniae 5 parts, Radix Paeoniae Rubra 10 parts, Flos Lonicerae 6 parts, Fructus Gardeniae 6 parts, Rhizoma Et Radix Notopterygii 6 parts, Radix Scutellariae 13 parts, Rhizoma Chuanxiong 12 parts, the Radix Angelicae Dahuricae 10 parts, Herba Schizonepetae 6 parts, Radix Saposhnikoviae 10 parts, Radix Sophorae Flavescentis 6 parts, Radix Scrophulariae 4 parts and 14 parts, Radix Glycyrrhizae by following parts by weight.

Preparation method is as follows:

(1): get Caulis Spatholobi, wash away impurity, crushed after being dried, cross 140 mesh sieves, adding Caulis Spatholobi coarse powder gross weight 6 times amount volume fraction is the ethanol of 80%, add the cellulase of Caulis Spatholobi coarse powder total amount 1.2% again, lixiviate 2 hours at 45 DEG C, then 75 DEG C of reflux, extract, 2 hours, filters and retains Caulis Spatholobi filtering residue, at filtrate reduced in volume to 50 DEG C, relative density is the extractum of 1.25, obtains Caulis Spatholobi extract;

(2): get Radix Rehmanniae, Flos Chrysanthemi, Herba Taraxaci, Cortex Dictamni, Herba Houttuyniae, Radix Paeoniae Rubra, Flos Lonicerae, Fructus Gardeniae, Rhizoma Et Radix Notopterygii, Radix Scutellariae, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Schizonepetae, Radix Saposhnikoviae, Radix Sophorae Flavescentis, Radix Scrophulariae and Radix Glycyrrhizae, above-mentioned Chinese crude drug is pulverized, the 6 times of concentration adding above-mentioned coarse powder gross weight are the alcoholic solution of 75%, reflux, extract, 3 times, each 4h, filters, decompression filtrate recycling ethanol, cold filtration, washes with water, obtains Chinese medical concrete;

(3): the Chinese medical concrete that Caulis Spatholobi extract step (1) obtained and step (2) obtain mixes, dry, add corresponding adjuvant, make powder.

pharmaceutical composition of the present invention is on the impact of the ear swelling that ultraviolet causes

1, experimental animal: Healthy female SD rat, body weight 0.22kg-0.3kg, is provided by Zhongshan University's animal experimental center; Rat freely absorbs conventional feed and tap water, and raising room temperature is 18 DEG C-25 DEG C.

2, trial drug: gel ointment prepared by the embodiment of the present invention 1.

The object of this test is whether the effect resisting solar dermatitis in order to study Chinese medicine composition of the present invention is better than other drug.Use uviol lamp to mice Continuous irradiation, object is the sunshine environment of simulation mice.When mice causes suffering from solar dermatitis because being exposed to continuously in uviol lamp environment, one of its performance is mice ear inflammation.The left ear be exposed under uviol lamp and the auris dextra be blocked are carried out contrast of weighing, calculates ear swelling value.Contrast the antiinflammation that the ear swelling value of smearing the mice of different pharmaceutical can draw different pharmaceutical, ear swelling value is less, and the curative effect of medicine is better.

3, test method

Get SD rat 36, be divided into 3 groups at random, often organize 12, be respectively blank group, the yellow happy ointment of skin of ice and treatment group.The gel ointment that treatment group uses embodiment 1 to prepare, positive controls is the yellow happy ointment of the skin (Tibet Zhizhi Pharmacy Group Co., Ltd., the accurate word Z10980140 of traditional Chinese medicines) of ice; Be horizontally fixed on by mice on brandreth, with uviol lamp (40WUVA fluorescent tube 3, UVB fluorescent tube 1 vertical dimension 10cm), irradiate 2 weeks, every day, Continuous irradiation 6h, covered animal head and auris dextra with cardboard between the light period.Except blank group, all the other respectively organize and quantitatively use Relative drug to smear mice left ear every day.Irradiation 40h, cuts the left ear of mice respectively and auris dextra is weighed, and calculates ear swelling value (mg).Swelling value=left ear weight-auris dextra weight.

4, result of the test

4.1, general status is observed: after irradiating 3d, serious large redness, desquamation appear in the irradiated left ear skin of blank group mice; Present composition mouse ear skin injury situation is comparatively light, and desquamation phenomenon is less, and the mouse ear skin injury situation of the yellow skin of ice happy ointment group is more serious than present composition mice.Irradiate after 14d, the mouse ear skin injury of the happy ointment group of the yellow skin of ice is serious, and the irradiated left ear skin of mice presents lamellar erythema, festers, vesicle, thicken, tarnish and elasticity, obviously aging; Present composition group mouse ear skin symptom is obviously lighter than positive controls, and erythema is few, ulceration is light, vesicle quantity is few, pachyderma is not obvious.

4.2, anaphylaxis level index:

Table 1 pharmaceutical composition of the present invention is on the impact of ultraviolet induced mice ear swelling

Note: compare with blank group, * p< 0.05, * * p< 0.01

Result show, compare with blank group, Chinese medicine composition of the present invention can significantly reduce ultraviolet induced mice ear swelling value ( p< 0.01), show that Chinese medicine composition of the present invention has the effect significantly suppressing the mice ear caused by ultraviolet.Under same experiment condition, the happy ointment group of the yellow skin of ice also significantly reduce ear swelling value ( p< 0.05), but its antiphlogistic effects is obviously not as good as Chinese medicine composition of the present invention.Visible, Chinese medicine composition of the present invention has significant curative effect in treatment solar dermatitis.

clinical observation on the therapeutic effect

1, case selection: in 150 routine solar dermatitis disease clinical volunteers patients, man 90 example, female 60 example, at minimum 18 years old of age, maximum 50 years old, all patients all met solar dermatitis symptom, site of pathological change: face, cervical region, two upper limb.

2, exclusion standard:

(1), Complicated with Severe internal medicine disease patient;

(2), drug allergy body constitution patient;

(3), gestation, women breast-feeding their children.

3, criterion of therapeutical effect:

(1) cure: erythra all disappears, red and swollen, pain disappears;

(2) effective: deflorescence is greater than 70%;

(3) effective: deflorescence degree is between 30% to 70%;

(4) invalid: deflorescence is less than 30% or increase the weight of;

(5) total effective rate=(curing number+effective number+efficiently individual quantity)/total number of persons * 100%.

4, instructions of taking: 150 patients are divided into 3 groups at random, often organize 50 people, be respectively treatment A group, treatment B group and treatment C group, use the medicine that the embodiment of the present invention 1,2,3 prepares respectively, external, every day 2-3 time, gets 5g at every turn, continuous use one week.

5, therapeutic outcome:

In 150 routine solar dermatitis patients, cure 134 examples, effective 6 examples, effective 4 examples, invalid 6 examples, cure rate reaches 89.3%, and total effective rate is 96%, and the cure rate of wherein treating C group is the highest; Visible, particularly the curative effect of medication for preparing of the embodiment of the present invention 3 is good for pharmaceutical composition of the present invention, and cure rate is high, can as the drug use for the treatment of solar dermatitis disease.

Owing to describing the present invention by above preferred embodiment, in spirit of the present invention and/or scope, any for replacement/of the present invention or combination implement the present invention, be all apparent for a person skilled in the art, and be included among the present invention.

Claims (6)

1. treat the pharmaceutical composition of solar dermatitis for one kind, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Caulis Spatholobi 5-15 part, Radix Rehmanniae 10-16 part, Flos Chrysanthemi 4-10 part, Herba Taraxaci 4-10 part, Cortex Dictamni 5-9 part, Herba Houttuyniae 3-6 part, Radix Paeoniae Rubra 8-12 part, Flos Lonicerae 3-9 part, Fructus Gardeniae 4-8 part, Rhizoma Et Radix Notopterygii 4-8 part, Radix Scutellariae 5-17 part, Rhizoma Chuanxiong 9-15 part, Radix Angelicae Dahuricae 4-14 part, Herba Schizonepetae 4-9 part, Radix Saposhnikoviae 4-12 part, Radix Sophorae Flavescentis 5-10 part, Radix Scrophulariae 3-6 part and Radix Glycyrrhizae 8-16 part.

2. the pharmaceutical composition for the treatment of solar dermatitis as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Caulis Spatholobi 5 parts, Radix Rehmanniae 10 parts, Flos Chrysanthemi 4 parts, Herba Taraxaci 4 parts, Cortex Dictamni 5 parts, Herba Houttuyniae 3 parts, Radix Paeoniae Rubra 8 parts, Flos Lonicerae 3 parts, Fructus Gardeniae 4 parts, Rhizoma Et Radix Notopterygii 4 parts, Radix Scutellariae 5 parts, Rhizoma Chuanxiong 9 parts, the Radix Angelicae Dahuricae 4 parts, Herba Schizonepetae 4 parts, Radix Saposhnikoviae 4 parts, Radix Sophorae Flavescentis 5 parts, Radix Scrophulariae 3 parts and 8 parts, Radix Glycyrrhizae.

3. the pharmaceutical composition for the treatment of solar dermatitis as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Caulis Spatholobi 15 parts, Radix Rehmanniae 16 parts, Flos Chrysanthemi 10 parts, Herba Taraxaci 10 parts, Cortex Dictamni 9 parts, Herba Houttuyniae 6 parts, Radix Paeoniae Rubra 12 parts, Flos Lonicerae 9 parts, Fructus Gardeniae 8 parts, Rhizoma Et Radix Notopterygii 8 parts, Radix Scutellariae 17 parts, Rhizoma Chuanxiong 15 parts, the Radix Angelicae Dahuricae 14 parts, Herba Schizonepetae 9 parts, Radix Saposhnikoviae 12 parts, Radix Sophorae Flavescentis 10 parts, Radix Scrophulariae 6 parts and 16 parts, Radix Glycyrrhizae.

4. the pharmaceutical composition for the treatment of solar dermatitis as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Caulis Spatholobi 12 parts, Radix Rehmanniae 14 parts, Flos Chrysanthemi 6 parts, Herba Taraxaci 8 parts, Cortex Dictamni 7 parts, Herba Houttuyniae 5 parts, Radix Paeoniae Rubra 10 parts, Flos Lonicerae 6 parts, Fructus Gardeniae 6 parts, Rhizoma Et Radix Notopterygii 6 parts, Radix Scutellariae 13 parts, Rhizoma Chuanxiong 12 parts, the Radix Angelicae Dahuricae 10 parts, Herba Schizonepetae 6 parts, Radix Saposhnikoviae 10 parts, Radix Sophorae Flavescentis 6 parts, Radix Scrophulariae 4 parts and 14 parts, Radix Glycyrrhizae.

5. the pharmaceutical composition of the treatment solar dermatitis as described in any one of claim 1-4, is characterized in that: described pharmaceutical composition is made into gel ointment, spray or powder.

6. a preparation method for the pharmaceutical composition of the treatment solar dermatitis as described in any one of claim 1-4, is characterized in that, the preparation method of described pharmaceutical composition comprises following step:

(1): get Caulis Spatholobi, wash away impurity, crushed after being dried, cross 100-140 mesh sieve, adding Caulis Spatholobi coarse powder gross weight 3-6 times amount volume fraction is the ethanol of 75-80%, add the cellulase of Caulis Spatholobi coarse powder total amount 0.8%-1.2% again, lixiviate 1-2 hour at 38-45 DEG C, then at 65-75 DEG C of reflux, extract, 1-2 hour, filters and retains Caulis Spatholobi filtering residue, at filtrate reduced in volume to 50 DEG C, relative density is the extractum of 1.10-1.25, obtains Caulis Spatholobi extract;

(2): get Radix Rehmanniae, Flos Chrysanthemi, Herba Taraxaci, Cortex Dictamni, Herba Houttuyniae, Radix Paeoniae Rubra, Flos Lonicerae, Fructus Gardeniae, Rhizoma Et Radix Notopterygii, Radix Scutellariae, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Schizonepetae, Radix Saposhnikoviae, Radix Sophorae Flavescentis, Radix Scrophulariae and Radix Glycyrrhizae, above-mentioned Chinese crude drug is pulverized, the 4-6 times of concentration adding above-mentioned coarse powder gross weight is the alcoholic solution of 65-75%, reflux, extract, 2-3 time, each 2-4h, filters, decompression filtrate recycling ethanol, cold filtration, washes with water, obtains Chinese medical concrete;

(3): the Chinese medical concrete that Caulis Spatholobi extract step (1) obtained and step (2) obtain mixes, dry, to obtain final product.