CN108785497A - A kind of ointment and preparation method thereof for treating bone and joint diseases - Google Patents

A kind of ointment and preparation method thereof for treating bone and joint diseases Download PDF

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Publication number
CN108785497A
CN108785497A CN201811020802.3A CN201811020802A CN108785497A CN 108785497 A CN108785497 A CN 108785497A CN 201811020802 A CN201811020802 A CN 201811020802A CN 108785497 A CN108785497 A CN 108785497A
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parts
safflower
ointment
root
joint diseases
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南运东
朱鑫
吴志辉
张雷
刘亚莉
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A61K35/04—Tars; Bitumens; Mineral oils; Ammonium bituminosulfonate
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716—Clematis (leather flower)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/74—Rubiaceae (Madder family)
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K36/90—Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

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Abstract

The invention discloses a kind of ointment for treating bone and joint diseases, including below according to the raw material of parts by weight：20-40 parts of ammonium ichthosulfonate, 30-50 parts of safflower, 20-30 parts of Radix Astragali, 20-30 parts of Radix Angelicae Sinensis, 10-20 parts of the root of Dahurain angelica, 20-30 parts of the root of Chinese clematis, 10-20 parts of Rhizoma Chuanxiong, 5-10 parts of giant knotweed, 10-20 parts of Radix Glycyrrhizae, 6-12 parts of Du Ruo, 4-10 parts of safflower madder, 10-20 parts of SEMEN SINAPIS ALBAE, 5-10 parts of lanatechead saussurea herb with flower, 10-20 parts of Chinese ephedra, 5-10 parts of sweet mary, 5-10 parts of Caulis Spatholobi, 5-10 parts of chinaroot greenbrier, 2-6 parts of Rabdosia rubescens, 1-3 parts of borneol.The invention also discloses the preparation methods of the ointment of the treatment bone and joint diseases.Ointment prepared by the present invention can effectively treat bone and joint diseases, relieve pain, and symptom improves obviously, and ointment prepared by the present invention is suitable for most of bone and joint diseases, and therapeutic effect is good, uneasy to recur.

Description

A kind of ointment and preparation method thereof for treating bone and joint diseases
Technical field
The present invention relates to Bones and joints treatment technology field, the ointment of specifically a kind for the treatment of bone and joint diseases and its preparation side Method.
Background technology
Bones and joints are connected by the capsule for borrowing connective tissue to constitute between adjacent bone.Bone is indirectly connected with title Bones and joints with bone.Phase To bone face between there is lacuna, intracavitary to contain a small amount of synovia.Its movable amplitude is larger, and there are articular surface, joint in each joint Capsule, articular cavity.There is the supplementary structures such as ligament, articular disc and meniscus in certain joints.Human body why can activity freely, just It is because of the structure for having Bones and joints, most Bones and joints are not only to provide the need of physical activity, and via cartilage protection bone It avoids wearing.Bone and joint diseases are common clinicals, frequently-occurring disease, and in clinic, there are many disease of Bones and joints involvement, such as cervical vertebra Disease, waist dish outstanding, scapulohumeral periarthritis, rheumatic arthritis, rheumatoid arthritis etc..
Existing doctor trained in Western medicine is mainly oral drug therapy and operative treatment for the therapy of bone and joint diseases；Oral medicine Object treatment is not only difficult to effect a radical cure, is easy recurrence, can also cause larger burden to body, and the another fixed risk of operative treatment, takes It is also more painful with higher.Therefore, find it is a kind of safely, effectively and drug without side-effects is necessary.
Invention content
The purpose of the present invention is to provide a kind of ointment for treating bone and joint diseases, to solve to propose in above-mentioned background technology The problem of.
To achieve the above object, the present invention provides the following technical solutions：
A kind of ointment for treating bone and joint diseases, including below according to the raw material of parts by weight：20-40 parts of ammonium ichthosulfonate, safflower 30-50 parts, 20-30 parts of Radix Astragali, 20-30 parts of Radix Angelicae Sinensis, 10-20 parts of the root of Dahurain angelica, 20-30 parts of the root of Chinese clematis, 10-20 parts of Rhizoma Chuanxiong, giant knotweed 5- 10 parts, 10-20 parts of Radix Glycyrrhizae, 6-12 parts of Du Ruo, 4-10 parts of safflower madder, 10-20 parts of SEMEN SINAPIS ALBAE, 5-10 parts of lanatechead saussurea herb with flower, Chinese ephedra 10- 20 parts, 5-10 parts of sweet mary, 5-10 parts of Caulis Spatholobi, 5-10 parts of chinaroot greenbrier, 2-6 parts of Rabdosia rubescens, 1-3 parts of borneol.
As a further solution of the present invention：Including below according to the raw material of parts by weight：25-35 parts of ammonium ichthosulfonate, safflower 35- 45 parts, 22-28 parts of Radix Astragali, 22-28 parts of Radix Angelicae Sinensis, 12-18 parts of the root of Dahurain angelica, 22-28 parts of the root of Chinese clematis, 12-18 parts of Rhizoma Chuanxiong, 6-9 parts of giant knotweed, 12-18 parts of Radix Glycyrrhizae, 7-11 parts of Du Ruo, 5-9 parts of safflower madder, 12-18 parts of SEMEN SINAPIS ALBAE, 6-9 parts of lanatechead saussurea herb with flower, 12-18 parts of Chinese ephedra, perfume 6-8 parts of melissa, 7-9 parts of Caulis Spatholobi, 6-9 parts of chinaroot greenbrier, 3-5 parts of Rabdosia rubescens, 1.5-2.5 parts of borneol.
As further scheme of the invention：Including below according to the raw material of parts by weight：30 parts of ammonium ichthosulfonate, safflower 30 It is part, 25 parts of Radix Astragali, 25 parts of Radix Angelicae Sinensis, 15 parts of the root of Dahurain angelica, 24 parts of the root of Chinese clematis, 16 parts of Rhizoma Chuanxiong, 7 parts of giant knotweed, 16 parts of Radix Glycyrrhizae, 9 parts of Du Ruo, red 7 parts of madder of flower, 15 parts of SEMEN SINAPIS ALBAE, 8 parts of lanatechead saussurea herb with flower, 16 parts of Chinese ephedra, 7 parts of sweet mary, 8 parts of Caulis Spatholobi, 8 parts of chinaroot greenbrier, Rabdosia rubescens 4 Part, 2 parts of borneol.
As further scheme of the invention：The safflower madder refers to its inflorescence part.
As further scheme of the invention：The chinaroot greenbrier refers in particular to its berry part.
The preparation method of the ointment of the treatment bone and joint diseases, steps are as follows：
1) by safflower, Radix Astragali, Radix Angelicae Sinensis, the root of Dahurain angelica, the root of Chinese clematis, Rhizoma Chuanxiong, giant knotweed, Radix Glycyrrhizae, Du Ruo, safflower madder, SEMEN SINAPIS ALBAE, snow Lotus flower, Chinese ephedra, sweet mary, Caulis Spatholobi, chinaroot greenbrier, Rabdosia rubescens are put into after cleaning in container, smash to pieces, and 3-5 times of weight of Chinese medicine is added The ethanol solution of a concentration of 60-80% of part impregnates 12-24h, then the ultrasonic wave assisted extraction 10- for passing through 20-30KHz 20min obtains admixing medical solutions；
2) distilled water of 8-10 times of parts by weight of above-mentioned traditional Chinese medicinal material raw materials is added in the admixing medical solutions obtained to step 1), boils It is filtered with 1-2h is cooked by slow fire, after cooling filtrate is concentrated while hot again afterwards, it is 1.1-1.2g/ to be concentrated into room temperature lower density Cm^3 obtains the concentrated liquid of tradition Chinese medicine；
3) ammonium ichthosulfonate and borneol is added in the concentrated liquid of tradition Chinese medicine for obtaining step 2), ammonium ichthosulfonate is added in stirring container, It is stirred with 800-1000r/min rotating speeds, while being slowly added to acetic acid solution into stirring container, continue to stir 3- after the completion 5min, discharging obtain paste；
4) by the paste of step 3) the acquisition radiated by gamma-ray that irradiation dose is the generation of 6.0-8.0KG isotope Co 60s Sterilize 5-10min, you can.
Above-mentioned ointment is preparing the application in treating bone and joint diseases drug.
Compared with prior art, the beneficial effects of the invention are as follows：
Ointment prepared by the present invention can effectively treat bone and joint diseases under the common mating reaction of various raw materials, delay Pain is solved, symptom improves obviously, and ointment prepared by the present invention is suitable for most of bone and joint diseases, and therapeutic effect is good, is not easy Recurrence；For the present invention by concentrating in medicinal material drug effect in ammonium ichthosulfonate, ointment is easy to use, and drug effect is concentrated, is easy to by human body It absorbs, human body will not be caused to bear.
Specific implementation mode
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described, Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all Belong to the scope of protection of the invention.
Embodiment 1
A kind of ointment for treating bone and joint diseases, including below according to the raw material of parts by weight：20 parts of ammonium ichthosulfonate, safflower 30 It is part, 20 parts of Radix Astragali, 20 parts of Radix Angelicae Sinensis, 10 parts of the root of Dahurain angelica, 20 parts of the root of Chinese clematis, 10 parts of Rhizoma Chuanxiong, 5 parts of giant knotweed, 10 parts of Radix Glycyrrhizae, 6 parts of Du Ruo, red 4 parts of madder of flower, 10 parts of SEMEN SINAPIS ALBAE, 5 parts of lanatechead saussurea herb with flower, 10 parts of Chinese ephedra, 5 parts of sweet mary, 5 parts of Caulis Spatholobi, 5 parts of chinaroot greenbrier, Rabdosia rubescens 2 Part, 1 part of borneol.
Wherein, the safflower madder refers to its inflorescence part.
Wherein, the chinaroot greenbrier refers in particular to its berry part.
In the present embodiment, the preparation method of the ointment of the treatment bone and joint diseases, steps are as follows：
1) by safflower, Radix Astragali, Radix Angelicae Sinensis, the root of Dahurain angelica, the root of Chinese clematis, Rhizoma Chuanxiong, giant knotweed, Radix Glycyrrhizae, Du Ruo, safflower madder, SEMEN SINAPIS ALBAE, snow Lotus flower, Chinese ephedra, sweet mary, Caulis Spatholobi, chinaroot greenbrier, Rabdosia rubescens are put into after cleaning in container, smash to pieces, and 3 times of parts by weight of Chinese medicine are added A concentration of 60% ethanol solution, impregnate 12h, then pass through the ultrasonic wave assisted extraction 10min of 20KHz, obtain admixing medical solutions；
2) distilled water of 8 times of parts by weight of above-mentioned traditional Chinese medicinal material raw materials is added in the admixing medical solutions obtained to step 1), after boiling It again with 1h is cooked by slow fire, filters, filtrate is concentrated while hot after cooling, it is 1.1g/cm^3 to be concentrated into room temperature lower density, is obtained The concentrated liquid of tradition Chinese medicine；
3) ammonium ichthosulfonate and borneol is added in the concentrated liquid of tradition Chinese medicine for obtaining step 2), ammonium ichthosulfonate is added in stirring container, It is stirred with 800r/min rotating speeds, while being slowly added to acetic acid solution into stirring container, continued to stir 3min after the completion, discharge, Obtain paste；
4) paste that step 3) obtains is sterilized with the radiated by gamma-ray that irradiation dose is the generation of 6.0KG isotope Co 60s 5min, you can.
Embodiment 2
A kind of ointment for treating bone and joint diseases, including below according to the raw material of parts by weight：25 parts of ammonium ichthosulfonate, safflower 35 Part, 22 parts of Radix Astragali, 22 parts of Radix Angelicae Sinensis, 12 parts of the root of Dahurain angelica, 22 parts of the root of Chinese clematis, 12 parts of Rhizoma Chuanxiong, 6 parts of giant knotweed, 12 parts of Radix Glycyrrhizae, 11 parts of Du Ruo, 9 parts of safflower madder, 18 parts of SEMEN SINAPIS ALBAE, 9 parts of lanatechead saussurea herb with flower, 18 parts of Chinese ephedra, 8 parts of sweet mary, 9 parts of Caulis Spatholobi, 9 parts of chinaroot greenbrier, Rabdosia rubescens 5 Part, 2.5 parts of borneol.
Wherein, the safflower madder refers to its inflorescence part.
Wherein, the chinaroot greenbrier refers in particular to its berry part.
In the present embodiment, the preparation method of the ointment of the treatment bone and joint diseases, steps are as follows：
1) by safflower, Radix Astragali, Radix Angelicae Sinensis, the root of Dahurain angelica, the root of Chinese clematis, Rhizoma Chuanxiong, giant knotweed, Radix Glycyrrhizae, Du Ruo, safflower madder, SEMEN SINAPIS ALBAE, snow Lotus flower, Chinese ephedra, sweet mary, Caulis Spatholobi, chinaroot greenbrier, Rabdosia rubescens are put into after cleaning in container, smash to pieces, and 4 times of parts by weight of Chinese medicine are added A concentration of 70% ethanol solution, impregnate 18h, then pass through the ultrasonic wave assisted extraction 15min of 25KHz, obtain admixing medical solutions；
2) distilled water of 9 times of parts by weight of above-mentioned traditional Chinese medicinal material raw materials is added in the admixing medical solutions obtained to step 1), after boiling It again with 1.5h is cooked by slow fire, filters, filtrate is concentrated while hot after cooling, it is 1.15g/cm^3 to be concentrated into room temperature lower density, Obtain the concentrated liquid of tradition Chinese medicine；
3) ammonium ichthosulfonate and borneol is added in the concentrated liquid of tradition Chinese medicine for obtaining step 2), ammonium ichthosulfonate is added in stirring container, It is stirred with 900r/min rotating speeds, while being slowly added to acetic acid solution into stirring container, continued to stir 4min after the completion, discharge, Obtain paste；
4) paste that step 3) obtains is sterilized with the radiated by gamma-ray that irradiation dose is the generation of 7.0KG isotope Co 60s 8min, you can.
Embodiment 3
A kind of ointment for treating bone and joint diseases, including below according to the raw material of parts by weight：30 parts of ammonium ichthosulfonate, safflower 30 It is part, 25 parts of Radix Astragali, 25 parts of Radix Angelicae Sinensis, 15 parts of the root of Dahurain angelica, 24 parts of the root of Chinese clematis, 16 parts of Rhizoma Chuanxiong, 7 parts of giant knotweed, 16 parts of Radix Glycyrrhizae, 9 parts of Du Ruo, red 7 parts of madder of flower, 15 parts of SEMEN SINAPIS ALBAE, 8 parts of lanatechead saussurea herb with flower, 16 parts of Chinese ephedra, 7 parts of sweet mary, 8 parts of Caulis Spatholobi, 8 parts of chinaroot greenbrier, Rabdosia rubescens 4 Part, 2 parts of borneol.
Wherein, the safflower madder refers to its inflorescence part.
Wherein, the chinaroot greenbrier refers in particular to its berry part.
In the present embodiment, the preparation method of the ointment of the treatment bone and joint diseases, steps are as follows：
1) by safflower, Radix Astragali, Radix Angelicae Sinensis, the root of Dahurain angelica, the root of Chinese clematis, Rhizoma Chuanxiong, giant knotweed, Radix Glycyrrhizae, Du Ruo, safflower madder, SEMEN SINAPIS ALBAE, snow Lotus flower, Chinese ephedra, sweet mary, Caulis Spatholobi, chinaroot greenbrier, Rabdosia rubescens are put into after cleaning in container, smash to pieces, and 4 times of parts by weight of Chinese medicine are added A concentration of 70% ethanol solution, impregnate 18h, then pass through the ultrasonic wave assisted extraction 15min of 25KHz, obtain admixing medical solutions；
2) distilled water of 9 times of parts by weight of above-mentioned traditional Chinese medicinal material raw materials is added in the admixing medical solutions obtained to step 1), after boiling It again with 1.5h is cooked by slow fire, filters, filtrate is concentrated while hot after cooling, it is 1.15g/cm^3 to be concentrated into room temperature lower density, Obtain the concentrated liquid of tradition Chinese medicine；
3) ammonium ichthosulfonate and borneol is added in the concentrated liquid of tradition Chinese medicine for obtaining step 2), ammonium ichthosulfonate is added in stirring container, It is stirred with 900r/min rotating speeds, while being slowly added to acetic acid solution into stirring container, continued to stir 4min after the completion, discharge, Obtain paste；
4) paste that step 3) obtains is sterilized with the radiated by gamma-ray that irradiation dose is the generation of 7.0KG isotope Co 60s 8min, you can.
Embodiment 4
A kind of ointment for treating bone and joint diseases, including below according to the raw material of parts by weight：35 parts of ammonium ichthosulfonate, safflower 45 It is part, 28 parts of Radix Astragali, 28 parts of Radix Angelicae Sinensis, 18 parts of the root of Dahurain angelica, 28 parts of the root of Chinese clematis, 18 parts of Rhizoma Chuanxiong, 9 parts of giant knotweed, 18 parts of Radix Glycyrrhizae, 7 parts of Du Ruo, red 5 parts of madder of flower, 12 parts of SEMEN SINAPIS ALBAE, 6 parts of lanatechead saussurea herb with flower, 12 parts of Chinese ephedra, 6 parts of sweet mary, 7 parts of Caulis Spatholobi, 6 parts of chinaroot greenbrier, Rabdosia rubescens 3 Part, 1.5 parts of borneol.
Wherein, the safflower madder refers to its inflorescence part.
Wherein, the chinaroot greenbrier refers in particular to its berry part.
In the present embodiment, the preparation method of the ointment of the treatment bone and joint diseases, steps are as follows：
1) by safflower, Radix Astragali, Radix Angelicae Sinensis, the root of Dahurain angelica, the root of Chinese clematis, Rhizoma Chuanxiong, giant knotweed, Radix Glycyrrhizae, Du Ruo, safflower madder, SEMEN SINAPIS ALBAE, snow Lotus flower, Chinese ephedra, sweet mary, Caulis Spatholobi, chinaroot greenbrier, Rabdosia rubescens are put into after cleaning in container, smash to pieces, and 4 times of parts by weight of Chinese medicine are added A concentration of 70% ethanol solution, impregnate 18h, then pass through the ultrasonic wave assisted extraction 15min of 25KHz, obtain admixing medical solutions；
2) distilled water of 9 times of parts by weight of above-mentioned traditional Chinese medicinal material raw materials is added in the admixing medical solutions obtained to step 1), after boiling It again with 1.5h is cooked by slow fire, filters, filtrate is concentrated while hot after cooling, it is 1.15g/cm^3 to be concentrated into room temperature lower density, Obtain the concentrated liquid of tradition Chinese medicine；
3) ammonium ichthosulfonate and borneol is added in the concentrated liquid of tradition Chinese medicine for obtaining step 2), ammonium ichthosulfonate is added in stirring container, It is stirred with 900r/min rotating speeds, while being slowly added to acetic acid solution into stirring container, continued to stir 4min after the completion, discharge, Obtain paste；
4) paste that step 3) obtains is sterilized with the radiated by gamma-ray that irradiation dose is the generation of 7.0KG isotope Co 60s 8min, you can.
Embodiment 5
A kind of ointment for treating bone and joint diseases, including below according to the raw material of parts by weight：40 parts of ammonium ichthosulfonate, safflower 50 Part, 30 parts of Radix Astragali, 30 parts of Radix Angelicae Sinensis, 20 parts of the root of Dahurain angelica, 30 parts of the root of Chinese clematis, 20 parts of Rhizoma Chuanxiong, 10 parts of giant knotweed, 20 parts of Radix Glycyrrhizae, 12 parts of Du Ruo, 10 parts of safflower madder, 20 parts of SEMEN SINAPIS ALBAE, 10 parts of lanatechead saussurea herb with flower, 20 parts of Chinese ephedra, 10 parts of sweet mary, 10 parts of Caulis Spatholobi, 10 parts of chinaroot greenbrier, winter Insult careless 6 parts, 3 parts of borneol.
Wherein, the safflower madder refers to its inflorescence part.
Wherein, the chinaroot greenbrier refers in particular to its berry part.
In the present embodiment, the preparation method of the ointment of the treatment bone and joint diseases, steps are as follows：
1) by safflower, Radix Astragali, Radix Angelicae Sinensis, the root of Dahurain angelica, the root of Chinese clematis, Rhizoma Chuanxiong, giant knotweed, Radix Glycyrrhizae, Du Ruo, safflower madder, SEMEN SINAPIS ALBAE, snow Lotus flower, Chinese ephedra, sweet mary, Caulis Spatholobi, chinaroot greenbrier, Rabdosia rubescens are put into after cleaning in container, smash to pieces, and 5 times of parts by weight of Chinese medicine are added A concentration of 80% ethanol solution, impregnate for 24 hours, then pass through the ultrasonic wave assisted extraction 20min of 30KHz, obtain admixing medical solutions；
2) distilled water of 10 times of parts by weight of above-mentioned traditional Chinese medicinal material raw materials is added in the admixing medical solutions obtained to step 1), after boiling It again with 2h is cooked by slow fire, filters, filtrate is concentrated while hot after cooling, it is 1.2g/cm^3 to be concentrated into room temperature lower density, is obtained The concentrated liquid of tradition Chinese medicine；
3) ammonium ichthosulfonate and borneol is added in the concentrated liquid of tradition Chinese medicine for obtaining step 2), ammonium ichthosulfonate is added in stirring container, It is stirred with 1000r/min rotating speeds, while being slowly added to acetic acid solution into stirring container, continued to stir 5min after the completion, discharge, Obtain paste；
4) paste that step 3) obtains is sterilized with the radiated by gamma-ray that irradiation dose is the generation of 8.0KG isotope Co 60s 10min, you can.
Comparative example 1
Compared with Example 3, ammonium ichthosulfonate is free of, other are same as Example 3.
Comparative example 2
Compared with Example 3, safflower madder and chinaroot greenbrier are free of, other are same as Example 3.
Comparative example 3
Compared with Example 3, ammonium ichthosulfonate, safflower madder and chinaroot greenbrier are free of, other are same as Example 3.
Ointment prepared by embodiment 1-5 and comparative example 1-3 is tested for the property, test result is as shown in table 1.
Test basis：160 bone and joint diseases patients are chosen, age, gender are random, and disease site is random, every 20 people one Group, uses ointment of the present invention 3 months respectively, uses 1 time daily, application method：Ointment is applied to joint after cleaning before sleeping, is made With gauze bondage, gauze is removed after 8-10h, wiping cleans up.
Efficacy assessment standard：
It cures：Feeling of pain subsides completely, and symptom completely disappears.
It is effective：Feeling of pain subsides substantially, and symptom disappears substantially.
Effectively：Feeling of pain is alleviated, and symptom improves unobvious.
In vain：Feeling of pain is not alleviated, and symptom is without improvement.
Table 1
It, can from can be seen that the ointment of the invention prepared in result above under the common mating reaction of various raw materials Effectively treatment bone and joint diseases, relieve pain, and symptom improves obviously, and ointment prepared by the present invention is suitable for most of Bones and joints Disease, therapeutic effect is good, uneasy to recur.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie In the case of without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power Profit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent requirements of the claims Variation is included within the present invention.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art The other embodiment being appreciated that.

Claims (7)

1. a kind of ointment for treating bone and joint diseases, which is characterized in that including below according to the raw material of parts by weight：Ammonium ichthosulfonate 20- 40 parts, 30-50 parts of safflower, 20-30 parts of Radix Astragali, 20-30 parts of Radix Angelicae Sinensis, 10-20 parts of the root of Dahurain angelica, 20-30 parts of the root of Chinese clematis, Rhizoma Chuanxiong 10-20 Part, 5-10 parts of giant knotweed, 10-20 parts of Radix Glycyrrhizae, 6-12 parts of Du Ruo, 4-10 parts of safflower madder, 10-20 parts of SEMEN SINAPIS ALBAE, lanatechead saussurea herb with flower 5-10 Part, 10-20 parts of Chinese ephedra, 5-10 parts of sweet mary, 5-10 parts of Caulis Spatholobi, 5-10 parts of chinaroot greenbrier, 2-6 parts of Rabdosia rubescens, 1-3 parts of borneol.
2. the ointment for the treatment of bone and joint diseases according to claim 1, which is characterized in that including below according to parts by weight Raw material：25-35 parts of ammonium ichthosulfonate, 35-45 parts of safflower, 22-28 parts of Radix Astragali, 22-28 parts of Radix Angelicae Sinensis, 12-18 parts of the root of Dahurain angelica, root of Chinese clematis 22- 28 parts, 12-18 parts of Rhizoma Chuanxiong, 6-9 parts of giant knotweed, 12-18 parts of Radix Glycyrrhizae, 7-11 parts of Du Ruo, 5-9 parts of safflower madder, SEMEN SINAPIS ALBAE 12-18 Part, 6-9 parts of lanatechead saussurea herb with flower, 12-18 parts of Chinese ephedra, 6-8 parts of sweet mary, 7-9 parts of Caulis Spatholobi, 6-9 parts of chinaroot greenbrier, 3-5 parts of Rabdosia rubescens, borneol 1.5-2.5 part.
3. the ointment for the treatment of bone and joint diseases according to claim 2, which is characterized in that including below according to parts by weight Raw material：30 parts of ammonium ichthosulfonate, 30 parts of safflower, 25 parts of Radix Astragali, 25 parts of Radix Angelicae Sinensis, 15 parts of the root of Dahurain angelica, 24 parts of the root of Chinese clematis, 16 parts of Rhizoma Chuanxiong, giant knotweed 7 Part, 16 parts of Radix Glycyrrhizae, 9 parts of Du Ruo, 7 parts of safflower madder, 15 parts of SEMEN SINAPIS ALBAE, 8 parts of lanatechead saussurea herb with flower, 16 parts of Chinese ephedra, 7 parts of sweet mary, chicken blood 8 parts of rattan, 8 parts of chinaroot greenbrier, 4 parts of Rabdosia rubescens, 2 parts of borneol.
4. the ointment for the treatment of bone and joint diseases according to claim 1, which is characterized in that the safflower madder refers to its inflorescence Part.
5. the ointment for the treatment of bone and joint diseases according to claim 4, which is characterized in that the chinaroot greenbrier refers in particular to its berry portion Point.
6. a kind of preparation method of the ointment for the treatment of bone and joint diseases according to any one of claims 1 to 5, which is characterized in that packet Include following steps：
1）By safflower, Radix Astragali, Radix Angelicae Sinensis, the root of Dahurain angelica, the root of Chinese clematis, Rhizoma Chuanxiong, giant knotweed, Radix Glycyrrhizae, Du Ruo, safflower madder, SEMEN SINAPIS ALBAE, saussurea involucrata Flower, Chinese ephedra, sweet mary, Caulis Spatholobi, chinaroot greenbrier, Rabdosia rubescens are put into after cleaning in container, smash to pieces, and 3-5 times of parts by weight of Chinese medicine are added A concentration of 60-80% ethanol solution, impregnate 12-24h, then by the ultrasonic wave assisted extraction 10-20min of 20-30KHz, obtain Obtain admixing medical solutions；
2）To step 1）The distilled water of 8-10 times of parts by weight of above-mentioned traditional Chinese medicinal material raw materials is added in the admixing medical solutions of acquisition, after boiling again It with 1-2h is cooked by slow fire, filters, filtrate is concentrated while hot after cooling, it is 1.1-1.2g/cm^3 to be concentrated into room temperature lower density, Obtain the concentrated liquid of tradition Chinese medicine；
3）By step 2）Ammonium ichthosulfonate and borneol are added in the concentrated liquid of tradition Chinese medicine of acquisition, ammonium ichthosulfonate is added in stirring container, with 800-1000r/min rotating speeds stir, while acetic acid solution is slowly added into stirring container, continue to stir 3-5min after the completion, Discharging obtains paste；
4）By step 3）The paste of acquisition is that the radiated by gamma-ray that 6.0-8.0KG isotope Co 60s generate sterilizes with irradiation dose 5-10min, you can.
7. a kind of ointment according to any one of claims 1 to 5 is preparing the application in treating bone and joint diseases drug.
CN201811020802.3A 2018-09-03 2018-09-03 A kind of ointment and preparation method thereof for treating bone and joint diseases Pending CN108785497A (en)

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Publication number Priority date Publication date Assignee Title
CN103961424A (en) * 2014-06-04 2014-08-06 杜黎明 Traditional Chinese medicine formula for treating cervical spondylosis and preparation method of traditional Chinese medicine capsule preparation
CN105343207A (en) * 2015-10-27 2016-02-24 汪德里 Formulation of plaster
CN105982976A (en) * 2016-07-22 2016-10-05 褚桂生 Osteal penetrant for treating osteoarticular diseases and preparation method thereof

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