CN100396299C - Medication for treating astriction, and preparation method - Google Patents
Medication for treating astriction, and preparation method Download PDFInfo
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- CN100396299C CN100396299C CNB200510072336XA CN200510072336A CN100396299C CN 100396299 C CN100396299 C CN 100396299C CN B200510072336X A CNB200510072336X A CN B200510072336XA CN 200510072336 A CN200510072336 A CN 200510072336A CN 100396299 C CN100396299 C CN 100396299C
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Abstract
The present invention discloses a medicine for treating constipation and a preparation method thereof. The medicine is mainly formed by the preparation of rhubarb and pig gallbladder powder, and radix asteris, figwort root, immature bitter orange and areca seeds can be added so as to attain better functions. The present invention has the preparation steps: (1), half rhubarb is mixed with the pig gallbladder powder and is uniformly stirred by etanol after being taken and pulverized, and pulverization is carried out after sealing and drying are carried out; (2), after the rest half rhubarb is mixed with the other residual medicines, water is added for decoction and filtering, concentration is carried out at the temperature of 50 DEG C, concentrated supernatant fluid is continuously concentrated, and subsequently, etanol is added to be still placed for one night; (3), the solution is filtered, when the ethanol is recovered, the filter liquid is concentrated to form thick paste under the condition of 50 DEG C, drying is carried out by pressure reduction, and the pulverization is carried out once again; (4), fine powder generated in the step (3) is mixed with fine powder generated in the step (1), a proper amount of lactose is added and is uniformly mixed, and a granular substance is prepared and is loaded in capsules. The medicine of the present invention is suitable for various types of constipation and has the advantages of small toxic and side effect, obvious treatment effect and little possibility of recurrence after people stop taking the medicine.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of constipation and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Constipation is a kind of commonly encountered diseases, frequently-occurring disease, and the main cause that its produces is that feces was detained in intestinal of a specified duration, and the interval of defecation is longer, thereby makes the just matter of stool dry and hard or involved and abstruse not smooth.Modern medicine thinks that constipation is caused by multiple factor or disease, and it is mainly functional constipation and two kinds of situations of organic constipation.The traditional Chinese medical science thinks that then constipation is an independently disease that can take place separately, also usually occurs together among multiple lysis simultaneously, then is divided into constipation of excess type and constipation due to insufficiency two big classes clinically.At present, aspect the means of treatment constipation, also relatively lag behind, adopt surgical method mostly, as colectomy, encysted rectum repairing and internal rectum prolapsus fixation etc., these methods can not be satisfactory except curative effect, most patient is also not too acceptant; Though and the Western medicine curative effect is better, recurrence easily after drug withdrawal, and these medicines all have certain side effect; The Chinese medicine medicine mainly contains phenolphthalein tablet, glycerin, Fructus Cannabis Bolus etc. in addition, but the effect of these Drug therapys is not very desirable, and is difficult to satisfy the dissimilar constipation that a variety of causes causes.
Summary of the invention
The object of the present invention is to provide a kind of deficiency that can overcome existing medicine, be applicable to the medicine of all kinds constipation, this poisonous side effect of medicine is little, and is evident in efficacy, and is difficult for recurrence after the drug withdrawal.
Another object of the present invention provides the preparation method of this medicine.
For realizing that the technical scheme that purpose of the present invention adopts is: drug main of the present invention will be made by the raw material of following parts by weight: 50～75 parts of 225～300 parts of Radix Et Rhizoma Rhei and Pulvis Fellis Suiss.Preferred parts by weight are 56 parts of 278 parts of Radix Et Rhizoma Rhei and Pulvis Fellis Suiss.
Medicine of the present invention can also be made by the raw material of following parts by weight: 90～120 parts of 225～300 parts of Radix Et Rhizoma Rhei, 50～75 parts of Pulvis Fellis Suiss and Radix Asteriss.Preferred parts by weight are 111 parts of 278 parts of Radix Et Rhizoma Rhei, 56 parts of Pulvis Fellis Suiss and Radix Asteriss.
Medicine of the present invention can also be made by the raw material of following parts by weight: 180～240 parts of 225～300 parts of Radix Et Rhizoma Rhei, 50～75 parts of Pulvis Fellis Suiss, 90～120 parts of Radix Asteriss, 360～480 parts of Radix Scrophulariaes, 180～240 parts of Fructus Aurantiis and Semen Arecaes.Preferred parts by weight are 222 parts of 278 parts of Radix Et Rhizoma Rhei, 56 parts of Pulvis Fellis Suiss, 111 parts of Radix Asteriss, 444 parts of Radix Scrophulariaes, 222 parts of Fructus Aurantiis and Semen Arecaes.
The preparation method of the Pulvis Fellis Suis in the above-mentioned raw materials is for to break the Fel Sus domestica extractum of buying in into pieces, and oven dry is ground into powder and gets final product.
Medicine of the present invention can be made different dosage forms, wherein can be tablet, pill, water decoction or granule, also can be capsule or oral liquid,
The step that pharmaceutical dosage form wherein of the present invention is capsular preparation method is as follows: 1. get and mix and add ethanol with Pulvis Fellis Suis after half Radix Et Rhizoma Rhei is ground into coarse powder with it, stir, oven dry is ground into fine powder after airtight 2 hours; 2. adding 10 times of amounts of water after inciting somebody to action other half Radix Et Rhizoma Rhei and remaining other medicines mixing decocts 2～4 times, each 1～2 hour, filter after having decocted, under 50 ℃, mixed liquor is concentrated, make its relative density reach 1.02～1.05, the supernatant after will concentrating is again proceeded to concentrate, and makes the relative density of clear liquid reach 1.10～1.15 under 50 ℃, adding ethanol subsequently makes the determining alcohol of solution reach 60%～80%, standing over night; 3. filtering solution is 1.30～1.35 thick paste reclaim the alcoholic acid relative density that simultaneously filtrate is condensed under 50 ℃, and drying under reduced pressure is ground into fine powder; 4. the fine powder of step in 3. and the step fine powder in is 1. mixed, add an amount of lactose and mix homogeneously, make granularly, be loaded on capsule.
Above-mentioned steps 1. in employed concentration of ethanol be 70%～80%.
Above-mentioned steps 1. in employed concentration of ethanol be 75%.
The above-mentioned steps 2. determining alcohol of middle solution is 70%.
Medicament selection Radix Et Rhizoma Rhei of the present invention and Pulvis Fellis Suis make up, and wherein the Radix Et Rhizoma Rhei bitter in the mouth is cold in nature, and the function of heat and toxic materials clearing away, clearing away heat-fire, detoxifcation, blood circulation promoting and blood stasis dispelling is arranged.Cure mainly the long-pending heat of intestinal, constipation, various bleeding due to blood-heaies, dominance of heat in the interior disease, various blood stasis symptoms.It rushes down following mechanism is that the oral back of its effective ingredient is that the product of biologically active is brought into play purging and intestine lubricating action by bacterial metabolism in digestive tract.Pharmacological research confirms that after the Radix Et Rhizoma Rhei oral administration, conjunction type anthracene glycoside major part, is decomposed by bacterial enzyme to large intestine without little intestinal absorption, is reduced into stronger anthrone of discharge function or anthrol, stimulates intestinal mucosa, strengthens enterokinesia.In addition, anthrone has the choline-like effect, and M-cholinoceptor on the excited intestinal smooth muscle is accelerated enterokinesia, suppresses Na on the intestinal smooth muscle simultaneously
+, k
+-ATP enzyme, blocking-up Na
+Be transferred in the cell from enteric cavity, the enteric cavity osmotic pressure is raise, keep large quantity of moisture.The intestinal contents volume enlarges, and the mechanical irritation intestinal wall increases enterokinesia.Pulvis Fellis Suis bitter in the mouth, cold in nature is gone into large intestine channel; Heat clearing away arranged, moisturize, the antidotal function; Can stimulate bile secretion, increase enterokinesia; It is dry thirsty to cure mainly calentura, diseases such as constipation.
In order to reach better therapeutic, medicine of the present invention can also add Radix Asteris, and Radix Asteris bitter in the mouth, suffering are warm in nature, return lung meridian; Nourishing the lung to keep the adverse QI downward is arranged, the function of preventing phlegm from forming and stopping coughing; Cure mainly deficiency of the lung chronic cough, diseases such as consumptive lung disease lung abscess.
In order to reach optimum curative effect, medicine of the present invention can also add Radix Scrophulariae, Fructus Aurantii Immaturus and Semen Arecae.Wherein Radix Scrophulariae sweet in the mouth, hardship, salty; The function that clearing away heat and cooling blood, nourishing YIN to lower pathogenic fire, supplementing fluid to relax the bowels, detoxicating and resolving stagnation of pathogens are arranged; Cure mainly fidgets due to deficiency and be insomnia, constipation is hindered in Tianjin, diseases such as skin sore.Fructus Aurantii Immaturus bitter in the mouth, suffering, cold nature are returned spleen, stomach, large intestine channel; The dispelling the stagnated QI removing food stagnancy is arranged, reduce phlegm except that the function of painful abdominal mass; Cure mainly dyspeptic abdominal distention, feeling of fullness distension, diseases such as constipation.Semen Arecae bitter in the mouth, suffering, warm in nature, return stomach, large intestine channel; The function that removing food stagnancy sending down the abnormal ascending QI, row water are arranged; Cure mainly the stagnation of QI, malnutrition due to parasitic infestation, gastral cavilty expands and waits disease; The adding of Semen Arecae can help Radix Scrophulariae push away boat descending, help Radix Et Rhizoma Rhei to strengthen the stagnant power of promote qi circulation opening.
The present invention has following advantage:
1, the raw material selected for use of the present invention meets tcm theory, medication comprehensively and safety, toxic and side effects is little, can take for a long time.
2, the not only recent good effect of the present invention, its curative effect at a specified future date is equally also very good, after taking, Most patients all cures, and not recurrence, can play the effect of radical cure,
3, since with ethanol Radix Et Rhizoma Rhei has been carried out fried, thereby make the strength reduction of capturing of Radix Et Rhizoma Rhei, thereby do not have tangible discharge function.Select Pulvis Fellis Suis simultaneously for use, therefore can also strengthen digestive tract power, accelerated full bowel movement, can promote the smooth discharge of defecating.
4, the adding of other Radix Scrophulariae and Semen Arecae makes the effect that medicine of the present invention also has YIN supplementing and fluids increasing and moisturizes when having relieving constipation, the adding of Fructus Aurantii Immaturus and Radix Asteris then increase and regulates the flow of vital energy and leads to the effect of lung.
Below routine by experiment beneficial effect of further setting forth medicine of the present invention, these experimental examples comprise the pharmacodynamic experiment and the clinical observation on the therapeutic effect experiment of medicine of the present invention.
One, pharmacodynamic experiment
Experimental example 1
Medicine of the present invention is to the defecating feces excretion of normal mouse
Adopt normal mouse to observe the defecating feces excretion of medicine of the present invention.The result shows that in the 1h, the defecation frequency of each dosage group of medicine of the present invention all has increase trend than matched group after administration, but credit is analysed with matched group and relatively do not had significant difference (with matched group P＞0.05 relatively) by statistics.During administration 1～2h, the defecation frequency of each dosage group of medicine of the present invention also has increase trend than matched group.Defecation frequency after the accumulative total administration in the 2h, medicine 8.0g crude drug of the present invention/kg dosage group and 4.0g crude drug/kg dosage group has remarkable increase (P＜0.05 or P＜0.01) than matched group.From the feces character, 8.0g crude drug/kg dosage group feces in the 1h after administration is softer, and the feces of minority mice (2/10) is loose stool slightly, but this situation persistent period is very short, 1～2h after administration, and this group mice is all discharged shaping soft stool or normal feces.The feces of discharging after the 4.0g crude drug of medicine of the present invention/kg dosage group mice administration is soft slightly, all is shaped.Medicine 2.0g crude drug of the present invention/kg dosage group and 1.0g crude drug/kg dosage group defecation frequency in 0～2h after administration has increase trend than matched group, and feces character and matched group do not have significant difference.Positive control drug MAREN RUANJIAONANG group also has tangible defecating feces excretion to the intact animal.The result shows that medicine of the present invention has tangible defecating feces excretion to normal mouse, but without discharge function.
Experimental example 2
Medicine of the present invention is to the defecating feces excretion of dryness accumulated in the stomach and intestine dehydration mice with constipation
Adopt dryness accumulated in the stomach and intestine dehydration constipation model group mice to observe the defecating feces excretion of medicine of the present invention.The result shows, the normal matched group significantly less (P＜0.01) of the defecation frequency of dryness accumulated in the stomach and intestine dehydration constipation model group mice.Medicine 8.0 crude drugs of the present invention/kg dosage group and 4.0g crude drug/kg dosage group has significantly defecating feces excretion to dryness accumulated in the stomach and intestine dehydration mice with constipation, and effect is remarkable in 1～2h after administration.Defecation frequency in 0～2h significantly increases (with model group relatively P＜0.05 or P＜0.01) than model group during 1～2h and after the administration after administration, 8.0g crude drug/kg dosage treated animal feces is soft slightly, the feces of other dosage group is similar to the normal control group, there is no loose stool.Medicine 2.0g crude drug of the present invention/kg dosage group and 1.0g crude drug/kg dosage group does not have tangible defecating feces excretion to dryness accumulated in the stomach and intestine dehydration mice with constipation, and defecation frequency of animal and matched group relatively do not have remarkable increase.Defecation frequency after the administration of positive control drug MAREN RUANJIAONANG group in the 2h has increase trend than model group, but the no significance,statistical meaning of its effect.The result shows that medicine of the present invention has tangible defecating feces excretion at 8.0 dosage levels and 4.0h crude drug/kg dosage level to dryness accumulated in the stomach and intestine dehydration mice with constipation animal, and its effect is strong than the positive control drug MAREN RUANJIAONANG.
Experimental example 3
Medicine of the present invention is stopped up the defecating feces excretion of the mice with constipation that stagnates to excess-heat
Adopt excess-heat to stop up the defecating feces excretion that stagnant constipation model group mice is observed medicine of the present invention.The result shows that the normal matched group of defecation frequency that excess-heat is stopped up in the constipation model group mice 2h that stagnates significantly reduces (P＜0.01).Medicine 4.0,2.0 of the present invention, 1.0g crude drug/kg dosage level all have tangible defecating feces excretion to the stagnant mice with constipation of excess-heat heap soil or fertilizer over and around the roots, defecation frequency after the administration in the 2h increases (with model group relatively P＜0.05 or P＜0.01) than model group, its defecating feces excretion during 1～2h after the administration significantly.4.0g the feces of crude drug/kg is soft slightly, but still is shaped no loose stool.The feces of other dosage group is similar to the normal control group.Defecation frequency after the administration of positive controls drug anesthesia seed soft capsule group in the 2h significantly increases (comparing P＜0.05 with model group) than model group, also shows tangible defecating feces excretion.The result shows that medicine of the present invention is stopped up the mice with constipation that stagnates to excess-heat and had tangible defecating feces excretion, and its effect is close with MAREN RUANJIAONANG.
Experimental example 4
Medicine of the present invention is to the defecating feces excretion of class treaitng Yin-deficiency constipation mice
Thyroxine class treaitng Yin-deficiency constipation mice constipation due to dry stool, defecation is not smooth, count at the excrement that each discharges in observation stage (0～2h and 2～4h) with and the total defecation point number average of 0～4h in the whole observation period obviously reduce (P＜0.01) than matched group.The defecation frequency of medicine 8.0g crude drug of the present invention/kg dosage group and 4.0g crude drug/kg dosage group 2～4h after the last administration increases, the excrement of its discharge is counted and is significantly increased (P＜0.05) than model group, 8.0g crude drug/kg dosage group 0～4h in the observation period total excrement count and also significantly increase than model group.MAREN RUANJIAONANG also has the defecation of promotion trend to class deficiency of YIN mice, but compares no significant difference with model group statistically.The result shows that medicine of the present invention has tangible defecating feces excretion to the class treaitng Yin-deficiency constipation.
Experimental example 5
Medicine of the present invention is to the influence of class treaitng Yin-deficiency constipation mouse intestinal water content
The normal matched group of the average intestinal weight in wet base of thyroid class deficiency of YIN model group mice obviously reduces (P＜0.05), because model group intestinal wall attenuation, the intestinal dry weight also significantly reduces than normal group, so relatively do not have significant difference (P＞0.05) according to the water content and the normal control group of aforementioned formula calculating.The intestinal weight in wet base of medicine 10,2.0 of the present invention, 4.0g crude drug/kg group all significantly increases (P＜0.05 or P＜0.01) than model group, and the intestinal water content of each dosage group all has the trend of increasing than model group, but no significant difference on the statistics.The result shows that medicine of the present invention has more weak increase effect to the intestinal water content of class deficiency of YIN mice.
Experimental example 6
Medicine of the present invention is to the influence of dryness accumulated in the stomach and intestine dehydration mice with constipation intestinal water content
Adopt dryness accumulated in the stomach and intestine dehydration constipation model mice to observe the influence of medicine of the present invention to the intestinal water content.The result shows that the normal matched group of the intestinal water content of dryness accumulated in the stomach and intestine dehydration mice with constipation has reduction trend.The intestinal water content of medicine 8.0g crude drug of the present invention/kg dosage group significantly increases (P＜0.01) than model group, and the intestinal water content of 1.0,2.0 and the 4.0g crude drug/kg group has increase trend than model group, but no significant difference (P＞0.05) on the statistics.The result shows that medicine 8.0g crude drug/kg of the present invention can make the intestinal water content of dryness accumulated in the stomach and intestine dehydration mice with constipation increase, and other dosage level also has the trend that increases the intestinal water content, points out medicine of the present invention that the effect that keeps intestinal moisture is arranged.
Experimental example 7
Medicine of the present invention is to the influence of dryness accumulated in the stomach and intestine dehydration mice with constipation harmonization of the stomach intestinal propulsion motion
Adopt mice dryness accumulated in the stomach and intestine dehydration constipation model to observe the influence of medicine of the present invention, whether have the effect that improves the harmonization of the stomach small intestine power to understand it to the intestinal propulsion rate.A little less than the result's demonstration, the harmonization of the stomach small intestine power of dryness accumulated in the stomach and intestine dehydration constipation model group mice relatively, peristaltic velocity significantly slows down, and the normal matched group of intestinal propulsion rate significantly reduces (P＜0.01).Medicine 1.0～8.0g crude drug of the present invention/kg dosage water on average can significantly promote the intestinal propulsion motion of dryness accumulated in the stomach and intestine dehydration mice with constipation, and the intestinal propulsion rate of each administration group all significantly increases (P＜0.05 or P＜0.01) than model group.Positive control MAREN RUANJIAONANG group also can significantly promote the harmonization of the stomach intestinal motility of dryness accumulated in the stomach and intestine dehydration mice with constipation.The result shows that medicine of the present invention can improve the harmonization of the stomach small intestine power of dryness accumulated in the stomach and intestine dehydration mice with constipation, promotes the intestinal propulsion motion, and its effect is close with MAREN RUANJIAONANG.
Experimental example 8
Medicine of the present invention is to the influence of class treaitng Yin-deficiency constipation model mice harmonization of the stomach small intestinal
Adopt thyroxine class deficiency of YIN model, observe medicine of the present invention, whether class treaitng Yin-deficiency constipation person is had the effect of promotion harmonization of the stomach small intestine power to understand it to the divide a word with a hyphen at the end of a line influence of speed of gastrointestinal tract charcoal end.The result shows that the harmonization of the stomach small intestine power of thyroxine class deficiency of YIN model group mice reduces, and harmonization of the stomach small intestinal peristalsis speed obviously slows down, and divide a word with a hyphen at the end of a line distance and intestinal propulsion percentage rate and normal control group of charcoal end significantly reduces (P＜0.01) in its small intestinal.Medicine 1.0,2.0,4.0 of the present invention, 8.0g crude drug/kg can significantly promote the harmonization of the stomach intestinal motility of class deficiency of YIN mice, and divide a word with a hyphen at the end of a line distance and intestinal propulsion percentage rate of the charcoal end of each dosage group all significantly increases (with model group relatively P＜0.05 or P＜0.01) than model group.MAREN RUANJIAONANG can promote harmonization of the stomach small intestinal peristalsis to a certain extent, speed the charcoal end speed of dividing a word with a hyphen at the end of a line, but the effect of medicine of the present invention is strong than MAREN RUANJIAONANG.The result shows that medicine of the present invention has significant improvement effect to the harmonization of the stomach small intestine power of class deficiency of YIN mice.
Experimental example 9
Medicine of the present invention is to the influence of the full bowel movement of normal mouse
Adopt normal mice, observed medicine of the present invention to mice from giving charcoal last influence to efflux time, whether have facilitation to understand its full intestinal ahead running to mice.After mouse stomach gave medicine 8.0g crude drug/kg of the present invention and 4.0g crude drug/kg, the full intestinal ahead running of mice speeded up, and the normal matched group of defecation time significantly shortens (P＜0.01 or P＜0.05).The defecation frequency of medicine 2.0g crude drug/kg of the present invention and 1.0g crude drug/kg dosage group has shortening trend than matched group, but no significant difference (P＞0.05) on the statistics.The defecation time of positive control MAREN RUANJIAONANG also significantly shortens (P＜0.05) than matched group.The result shows that medicine 8.0g crude drug/kg of the present invention and 4.0g crude drug/kg have the full intestinal progradation of the mice of promotion, quicken the effect of defecation.
Experimental example 10
Medicine of the present invention is to the influence of the full bowel movement of class treaitng Yin-deficiency constipation mice
Adopt thyroxine class Yin deficiency models, observed medicine of the present invention and given charcoal last influence, whether have facilitation to understand its full intestinal ahead running to class deficiency of YIN mice to efflux time to class deficiency of YIN mice.The result shows that the full bowel movement speed of class deficiency of YIN model group mice slows down, and the normal matched group of defecation frequency significantly slows down, and its melena efflux time is obviously delayed (comparing P＜0.01 with the normal control group), shows that this model has the constipation performance.Medicine 4.0g crude drug/kg of the present invention and 8.0g crude drug/kg have facilitation to the full bowel movement of class deficiency of YIN group mice, defecation is speeded up, its melena efflux time significantly shortens (relatively being respectively P＜0.05, P＜0.01 with model group) than model group, and its effect has the doses relation.The positive control MAREN RUANJIAONANG also has the full intestinal ahead running of obvious promotion class deficiency of YIN mice, quickens defecation.The result shows that medicine of the present invention can promote the full bowel movement of class deficiency of YIN mice, promotes defecation, and the class treaitng Yin-deficiency constipation is had defecating feces excretion.
The above results shows that medicine of the present invention is stopped up stagnate model, dryness accumulated in the stomach and intestine dehydration constipation model and class treaitng Yin-deficiency constipation model mice to normal mouse, excess-heat and all had tangible defecating feces excretion.The intestinal water content that it can increase dryness accumulated in the stomach and intestine dehydration mice with constipation and class treaitng Yin-deficiency constipation mice has YIN supplementing and fluids increasing and moisturizes effect.Medicine of the present invention also can strengthen the digestive tract power of mice, accelerates full bowel movement, promotes the smooth discharge of stool, has the logical lung effect of regulating the flow of vital energy.Medicine of the present invention does not have tangible discharge function in the performance defecating feces excretion.
Two, clinical observation on the therapeutic effect experiment
Experimental example 11
The comparison of operation back defecation situation
1, physical data
Collect anorectal section operation case 216 examples, wherein internal hemorrhoid, external hemorrhoid, mixed hemorrhoid, ring-shaped mixed hemorrhoids 103 examples; Anal fissure 27 examples; Anal fistula 74 examples; Sick 12 examples of planting in other anus positions.13～78 years old age, 43.36 years old mean age.Male's 121 examples; Women's 95 examples.39 examples of constipation history are arranged before the operation, account for 18.05%.
2, diagnostic criteria
Carry out by the industry standard that State Administration of Traditional Chinese Medicine issues
3, Therapeutic Method
Perform the operation and began to take 10 of embodiment 11 drug prepared (3 gram), later every day three times, each 10 back evening on the same day.Organize in contrast with the patient who does not take any medicine after the operation, observe the defecation situation of two groups of patients in back two days of the operation.
4, observed result (seeing Table 1)
The influence of the defecation in the table 1 medicine adversary of the present invention postoperative two days
Annotate: compare P＜0.01 with matched group
From the result of table 1 as can be seen, the patient who has taken medicine of the present invention after the operation and the patient who the does not take medicine difference very remarkable (P＜0.01) of defecation smoothly in back two days of operation, and, taken behind the medicine of the present invention smoothly the effect of defecation more obviously (P＜0.005 as calculated) for before the operation patient of constipation history being arranged.
Experimental example 12
The comparison of pain degree when performing the operation the back defecation
1, physical data
Collect anorectal section operation case 108 examples.
2, diagnostic criteria
Pain criterion is as follows from intending:
+ painless, mild pain or pain can be born
++ moderate pain, the general analgesic drug product of adhib.
+++severe pain, must use strong analgesic.
3, Therapeutic Method
Perform the operation and began to take 10 of medicines of the present invention (3 gram), later every day three times, each 10 back evening on the same day.Organize pain situation when observing the defecation of two groups of patients in back two days of the operation in contrast with the patient who does not take any medicine after the operation.
4, observed result (seeing Table 2)
The influence of pain during defecation in the table 2 medicine adversary of the present invention postoperative two days
Annotate: compare P＜0.005 with matched group
From the result of table 2 as can be seen, take the patient of medicine of the present invention after the operation, its defecation pain degree obviously alleviates (P＜0.005), and the reason that alleviates then is quality and the compliance that medicine of the present invention has changed stool.
The specific embodiment
Embodiment 1
Take by weighing each raw material by following parts by weight: Radix Et Rhizoma Rhei 278g, Pulvis Fellis Suis 56g are standby.Preparation according to the following steps: 1. get half Radix Et Rhizoma Rhei powder and be broken into coarse powder, mix and add 75% ethanol then with Pulvis Fellis Suis, stir, oven dry is pulverized once more after airtight 2 hours, crosses 100 mesh sieves; 2. half Radix Et Rhizoma Rhei adds 10 times of amount decoctions of water 3 times in addition, each 1 hour, filter after having decocted, under 50 ℃, mixed liquor is concentrated, make its relative density reach 1.02～1.05, the supernatant after will concentrating is again proceeded to concentrate, and makes the relative density of clear liquid reach 1.10～1.15 under 50 ℃, adding ethanol subsequently makes the determining alcohol of solution reach 70%, standing over night; 3. filtering solution is 1.30～1.35 thick paste reclaim the alcoholic acid relative density that simultaneously filtrate is condensed under 50 ℃, and drying under reduced pressure is pulverized subsequently, crosses 120 mesh sieves; 4. the fine powder of step in 3. and the step fine powder in is 1. mixed, add an amount of lactose and mix homogeneously, make granularly, be loaded on capsule.
Embodiment 2
Take by weighing each raw material by following parts by weight: Radix Et Rhizoma Rhei 225g, Pulvis Fellis Suis 50g are standby.Preparation according to the following steps: 1. get half Radix Et Rhizoma Rhei powder and be broken into coarse powder, mix and add 70% ethanol then with Pulvis Fellis Suis, stir, oven dry is pulverized once more after airtight 2 hours, crosses 80 mesh sieves; 2. half Radix Et Rhizoma Rhei adds 10 times of amount decoctions of water 2 times in addition, each 2 hours, filter after having decocted, under 50 ℃, mixed liquor is concentrated, make its relative density reach 1.02～1.05, the supernatant after will concentrating is again proceeded to concentrate, and makes the relative density of clear liquid reach 1.10～1.15 under 50 ℃, adding ethanol subsequently makes the determining alcohol of solution reach 60%, standing over night; 3. filtering solution is 1.30～1.35 thick paste reclaim the alcoholic acid relative density that simultaneously filtrate is condensed under 50 ℃, and drying under reduced pressure is pulverized subsequently, crosses 100 mesh sieves; 4. the fine powder of step in 3. and the step fine powder in is 1. mixed, add an amount of lactose and mix homogeneously, make granularly, be loaded on capsule.
Embodiment 3
Take by weighing each raw material by following parts by weight: Radix Et Rhizoma Rhei 300g, Pulvis Fellis Suis 75g are standby.Preparation according to the following steps: 1. get half Radix Et Rhizoma Rhei powder and be broken into coarse powder, mix and add 80% ethanol then with Pulvis Fellis Suis, stir, oven dry is pulverized once more after airtight 2 hours, crosses 100 mesh sieves; 2. half Radix Et Rhizoma Rhei adds 10 times of amount decoctions of water 4 times in addition, each 1 hour, filter after having decocted, under 50 ℃, mixed liquor is concentrated, make its relative density reach 1.02～1.05, the supernatant after will concentrating is again proceeded to concentrate, and makes the relative density of clear liquid reach 1.10～1.15 under 50 ℃, adding ethanol subsequently makes the determining alcohol of solution reach 80%, standing over night; 3. filtering solution is 1.30～1.35 thick paste reclaim the alcoholic acid relative density that simultaneously filtrate is condensed under 50 ℃, and drying under reduced pressure is pulverized subsequently, crosses 120 mesh sieves; 4. the fine powder of step in 3. and the step fine powder in is 1. mixed, add an amount of lactose and mix homogeneously, make granularly, be loaded on capsule.
Embodiment 4
Take by weighing each raw material by following parts by weight: Radix Et Rhizoma Rhei 300g, Pulvis Fellis Suis 75g are standby.Be made into tablet according to a conventional method.
Embodiment 5
Take by weighing each raw material by following parts by weight: Radix Et Rhizoma Rhei 250g, Pulvis Fellis Suis 50g are standby.Be made into granule according to a conventional method.
Embodiment 6
Take by weighing each raw material by following parts by weight: Radix Et Rhizoma Rhei 278g, Pulvis Fellis Suis 56g and Radix Asteris 111g are standby.Preparation according to the following steps: 1. get half Radix Et Rhizoma Rhei powder and be broken into coarse powder, mix and add 75% ethanol then with Pulvis Fellis Suis, stir, oven dry is pulverized once more after airtight 2 hours, crosses 100 mesh sieves; 2. adding 10 times of amounts of water after inciting somebody to action other half Radix Et Rhizoma Rhei and Radix Asteris mixing decocts 3 times, each 1.5 hours, filter after having decocted, under 50 ℃, mixed liquor is concentrated, make its relative density reach 1.02～1.05, the supernatant after will concentrating is again proceeded to concentrate, and makes the relative density of clear liquid reach 1.10～1.15 under 50 ℃, adding ethanol subsequently makes the determining alcohol of solution reach 70%, standing over night; 3. filtering solution is 1.30～1.35 thick paste reclaim the alcoholic acid relative density that simultaneously filtrate is condensed under 50 ℃, and drying under reduced pressure is pulverized subsequently, crosses 120 mesh sieves; 4. the fine powder of step in 3. and the step fine powder in is 1. mixed, add an amount of lactose and mix homogeneously, make granularly, be loaded on capsule.
Embodiment 7
Take by weighing each raw material by following parts by weight: Radix Et Rhizoma Rhei 230g, Pulvis Fellis Suis 52g and Radix Asteris 100g are standby.Preparation according to the following steps: 1. get half Radix Et Rhizoma Rhei powder and be broken into coarse powder, mix and add 70% ethanol then with Pulvis Fellis Suis, stir, oven dry is pulverized once more after airtight 2 hours, crosses 80 mesh sieves; 2. adding 10 times of amounts of water after inciting somebody to action other half Radix Et Rhizoma Rhei and Radix Asteris mixing decocts 2 times, each 2 hours, filter after having decocted, under 50 ℃, mixed liquor is concentrated, make its relative density reach 1.02～1.05, the supernatant after will concentrating is again proceeded to concentrate, and makes the relative density of clear liquid reach 1.10～1.15 under 50 ℃, adding ethanol subsequently makes the determining alcohol of solution reach 65%, standing over night; 3. filtering solution is 1.30～1.35 thick paste reclaim the alcoholic acid relative density that simultaneously filtrate is condensed under 50 ℃, and drying under reduced pressure is pulverized subsequently, crosses 100 mesh sieves; 4. the fine powder of step in 3. and the step fine powder in is 1. mixed, add an amount of lactose and mix homogeneously, make granularly, be loaded on capsule.
Embodiment 8
Take by weighing each raw material by following parts by weight: Radix Et Rhizoma Rhei 280g, Pulvis Fellis Suis 70g and Radix Asteris 115g are standby.Preparation according to the following steps: 1. get half Radix Et Rhizoma Rhei powder and be broken into coarse powder, mix and add 80% ethanol then with Pulvis Fellis Suis, stir, oven dry is pulverized once more after airtight 2 hours, crosses 100 mesh sieves; 2. adding 10 times of amounts of water after inciting somebody to action other half Radix Et Rhizoma Rhei and Radix Asteris mixing decocts 4 times, each 1 hour, filter after having decocted, under 50 ℃, mixed liquor is concentrated, make its relative density reach 1.02～1.05, the supernatant after will concentrating is again proceeded to concentrate, and makes the relative density of clear liquid reach 1.10～1.15 under 50 ℃, adding ethanol subsequently makes the determining alcohol of solution reach 75%, standing over night; 3. filtering solution is 1.30～1.35 thick paste reclaim the alcoholic acid relative density that simultaneously filtrate is condensed under 50 ℃, and drying under reduced pressure is pulverized subsequently, crosses 120 mesh sieves; 4. the fine powder of step in 3. and the step fine powder in is 1. mixed, add an amount of lactose and mix homogeneously, make granularly, be loaded on capsule.
Embodiment 9
Take by weighing each raw material by following parts by weight: Radix Et Rhizoma Rhei 300g, Pulvis Fellis Suis 75g and Radix Asteris 120g are standby.Make pill according to a conventional method.
Embodiment 10
Take by weighing each raw material by following parts by weight: Radix Et Rhizoma Rhei 225g, Pulvis Fellis Suis 50g and Radix Asteris 90g are standby.Make water decoction according to a conventional method.
Embodiment 11
Take by weighing each raw material by following parts by weight: Radix Et Rhizoma Rhei 278g, Pulvis Fellis Suis 56g, Radix Asteris 111g, Radix Scrophulariae 444g, Fructus Aurantii 222g and Semen Arecae 222g are standby.Preparation according to the following steps: 1. get half Radix Et Rhizoma Rhei powder and be broken into coarse powder, mix and add 75% ethanol then with Pulvis Fellis Suis, stir, oven dry is pulverized once more after airtight 2 hours, crosses 80 mesh sieves; 2. adding 10 times of amounts of water after inciting somebody to action other half Radix Et Rhizoma Rhei and Radix Scrophulariae, Radix Asteris, Semen Arecae and Fructus Aurantii mixing decocts 3 times, each 1 hour, filter after having decocted, under 50 ℃, mixed liquor is concentrated, make its relative density reach 1.02～1.05, the supernatant after will concentrating is again proceeded to concentrate, and makes the relative density of clear liquid reach 1.10～1.15 under 50 ℃, adding ethanol subsequently makes the determining alcohol of solution reach 70%, standing over night; 3. filtering solution is 1.30～1.35 thick paste reclaim the alcoholic acid relative density that simultaneously filtrate is condensed under 50 ℃, and drying under reduced pressure is pulverized subsequently, crosses 100 mesh sieves; 4. the fine powder of step in 3. and the step fine powder in is 1. mixed, add an amount of lactose and mix homogeneously, make granularly, be loaded on capsule.
Embodiment 12
Take by weighing each raw material by following parts by weight: Radix Et Rhizoma Rhei 225g, Pulvis Fellis Suis 50g, Radix Asteris 90g, Radix Scrophulariae 360g, Fructus Aurantii 180g and Semen Arecae 180g are standby.Preparation according to the following steps: 1. get half Radix Et Rhizoma Rhei powder and be broken into coarse powder, mix and add 70% ethanol then with Pulvis Fellis Suis, stir, oven dry is pulverized once more after airtight 2 hours, crosses 100 mesh sieves; 2. adding 10 times of amounts of water after inciting somebody to action other half Radix Et Rhizoma Rhei and Radix Scrophulariae, Radix Asteris, Semen Arecae and Fructus Aurantii mixing decocts 2 times, each 1.5 hours, filter after having decocted, under 50 ℃, mixed liquor is concentrated, make its relative density reach 1.02～1.05, the supernatant after will concentrating is again proceeded to concentrate, and makes the relative density of clear liquid reach 1.10～1.15 under 50 ℃, adding ethanol subsequently makes the determining alcohol of solution reach 60%, standing over night; 3. filtering solution is 1.30～1.35 thick paste reclaim the alcoholic acid relative density that simultaneously filtrate is condensed under 50 ℃, and drying under reduced pressure is pulverized subsequently, crosses 120 mesh sieves; 4. the fine powder of step in 3. and the step fine powder in is 1. mixed, add an amount of lactose and mix homogeneously, make granularly, be loaded on capsule.
Embodiment 13
Take by weighing each raw material by following parts by weight: Radix Et Rhizoma Rhei 300g, Pulvis Fellis Suis 75g, Radix Asteris 120g, Radix Scrophulariae 480g, Fructus Aurantii 240g and Semen Arecae 240g are standby.Preparation according to the following steps: 1. get half Radix Et Rhizoma Rhei powder and be broken into coarse powder, mix and add 80% ethanol then with Pulvis Fellis Suis, stir, oven dry is pulverized once more after airtight 2 hours, crosses 80 mesh sieves; 2. adding 10 times of amounts of water after inciting somebody to action other half Radix Et Rhizoma Rhei and Radix Scrophulariae, Radix Asteris, Semen Arecae and Fructus Aurantii mixing decocts 4 times, each 1 hour, filter after having decocted, under 50 ℃, mixed liquor is concentrated, make its relative density reach 1.02～1.05, the supernatant after will concentrating is again proceeded to concentrate, and makes the relative density of clear liquid reach 1.10～1.15 under 50 ℃, adding ethanol subsequently makes the determining alcohol of solution reach 80%, standing over night; 3. filtering solution is 1.30～1.35 thick paste reclaim the alcoholic acid relative density that simultaneously filtrate is condensed under 50 ℃, and drying under reduced pressure is pulverized subsequently, crosses 100 mesh sieves; 4. the fine powder of step in 3. and the step fine powder in is 1. mixed, add an amount of lactose and mix homogeneously, make granularly, be loaded on capsule.
Embodiment 14
Take by weighing each raw material by following parts by weight: Radix Et Rhizoma Rhei 250g, Pulvis Fellis Suis 60g, Radix Asteris 100g, Radix Scrophulariae 400g, Fructus Aurantii 200g and Semen Arecae 200g are standby.Preparation according to the following steps: 1. get half Radix Et Rhizoma Rhei powder and be broken into coarse powder, mix and add 70% ethanol then with Pulvis Fellis Suis, stir, oven dry is pulverized once more after airtight 2 hours, crosses 80 mesh sieves; 2. adding 10 times of amounts of water after inciting somebody to action other half Radix Et Rhizoma Rhei and Radix Scrophulariae, Radix Asteris, Semen Arecae and Fructus Aurantii mixing decocts 2 times, each 2 hours, filter after having decocted, under 50 ℃, mixed liquor is concentrated, make its relative density reach 1.02～1.05, the supernatant after will concentrating is again proceeded to concentrate, and makes the relative density of clear liquid reach 1.10～1.15 under 50 ℃, adding ethanol subsequently makes the determining alcohol of solution reach 65%, standing over night; 3. filtering solution is 1.30～1.35 thick paste reclaim the alcoholic acid relative density that simultaneously filtrate is condensed under 50 ℃, and drying under reduced pressure is pulverized subsequently, crosses 100 mesh sieves; 4. the fine powder of step in 3. and the step fine powder in is 1. mixed, add an amount of lactose and mix homogeneously, make granularly, be loaded on capsule.
Embodiment 15
Take by weighing each raw material by following parts by weight: Radix Et Rhizoma Rhei 280g, Pulvis Fellis Suis 70g, Radix Asteris 110g, Radix Scrophulariae 440g, Fructus Aurantii 220g and Semen Arecae 220g are standby.Preparation according to the following steps: 1. get half Radix Et Rhizoma Rhei powder and be broken into coarse powder, mix and add 75% ethanol then with Pulvis Fellis Suis, stir, oven dry is pulverized once more after airtight 2 hours, crosses 100 mesh sieves; 2. adding 10 times of amounts of water after inciting somebody to action other half Radix Et Rhizoma Rhei and Radix Scrophulariae, Radix Asteris, Semen Arecae and Fructus Aurantii mixing decocts 3 times, each 1.5 hours, filter after having decocted, under 50 ℃, mixed liquor is concentrated, make its relative density reach 1.02～1.05, the supernatant after will concentrating is again proceeded to concentrate, and makes the relative density of clear liquid reach 1.10～1.15 under 50 ℃, adding ethanol subsequently makes the determining alcohol of solution reach 75%, standing over night; 3. filtering solution is 1.30～1.35 thick paste reclaim the alcoholic acid relative density that simultaneously filtrate is condensed under 50 ℃, and drying under reduced pressure is pulverized subsequently, crosses 120 mesh sieves; 4. the fine powder of step in 3. and the step fine powder in is 1. mixed, add an amount of lactose and mix homogeneously, make granularly, be loaded on capsule.
Embodiment 16
Take by weighing each raw material by following parts by weight: Radix Et Rhizoma Rhei 270g, Pulvis Fellis Suis 65g, Radix Asteris 115g, Radix Scrophulariae 460g, Fructus Aurantii 230g and Semen Arecae 230g are standby.Preparation process is prepared into oral liquid routinely.
Embodiment 17
Take by weighing each raw material by following parts by weight: Radix Et Rhizoma Rhei 240g, Pulvis Fellis Suis 55g, Radix Asteris 100g, Radix Scrophulariae 390g, Fructus Aurantii 190g and Semen Arecae 190g are standby.Preparation process is prepared into granule routinely.
Embodiment 18
Take by weighing each raw material by following parts by weight: Radix Et Rhizoma Rhei 225g, Pulvis Fellis Suis 50g, Radix Asteris 90g, Radix Scrophulariae 360g, Fructus Aurantii 180g and Semen Arecae 180g are standby.Preparation process is prepared into pill routinely.
Embodiment 19
Take by weighing each raw material by following parts by weight: Radix Et Rhizoma Rhei 300g, Pulvis Fellis Suis 75g, Radix Asteris 120g, Radix Scrophulariae 480g, Fructus Aurantii 240g and Semen Arecae 240g are standby.Preparation process is prepared into water decoction routinely.
Embodiment 20
Take by weighing each raw material by following parts by weight: Radix Et Rhizoma Rhei 278g, Pulvis Fellis Suis 56g, Radix Asteris 111g, Radix Scrophulariae 444g, Fructus Aurantii 222g and Semen Arecae 222g are standby.Preparation process is prepared into tablet routinely.
Claims (9)
1. medicine for the treatment of constipation, it is characterized in that: this drug main will be made by the raw material of following parts by weight: 225～300 parts of Radix Et Rhizoma Rhei, 50～75 parts of Pulvis Fellis Suiss, 90～120 parts of Radix Asteriss.
2. medicine according to claim 1 is characterized in that: this drug main will be made by the raw material of following parts by weight: 111 parts of 278 parts of Radix Et Rhizoma Rhei, 56 parts of Pulvis Fellis Suiss and Radix Asteriss.
3. medicine according to claim 1 is characterized in that: 180～240 parts of 360～480 parts of Radix Scrophulariaes, 180～240 parts of Fructus Aurantiis and Semen Arecaes can also be arranged in the raw material.
4. medicine according to claim 3 is characterized in that: this drug main will be made by the raw material of following parts by weight: 222 parts of 278 parts of Radix Et Rhizoma Rhei, 56 parts of Pulvis Fellis Suiss, 111 parts of Radix Asteriss, 444 parts of Radix Scrophulariaes, 222 parts of Fructus Aurantiis and Semen Arecaes.
5. according to the described medicine of one of claim 1 to 4, it is characterized in that: the dosage form of described medicine is a kind of in tablet, pill, water decoction, granule, capsule and the oral liquid.
6. method for preparing the described medicine of one of claim 1 to 4, it is characterized in that: comprise the following steps: 1. to get half Radix Et Rhizoma Rhei it is ground into coarse powder, mix and add ethanol then with Pulvis Fellis Suis, stir, oven dry is ground into fine powder after airtight 2 hours; 2. adding 10 times of amounts of water after inciting somebody to action other half Radix Et Rhizoma Rhei and remaining other medicines mixing decocts 2～4 times, each 1～2 hour, filter after having decocted, under 50 ℃, mixed liquor is concentrated, make its relative density reach 1.02～1.05, the supernatant after will concentrating is again proceeded to concentrate, and makes the relative density of clear liquid reach 1.10～1.15 under 50 ℃, adding ethanol subsequently makes the determining alcohol of solution reach 60%～80%, standing over night; 3. filtering solution is 1.30～1.35 thick paste reclaim the alcoholic acid relative density that simultaneously filtrate is condensed under 50 ℃, and drying under reduced pressure is ground into fine powder; 4. the fine powder of step in 3. and the step fine powder in is 1. mixed, add an amount of lactose and mix homogeneously, make granularly, be loaded on capsule.
7. method according to claim 6 is characterized in that: the above-mentioned steps 2. determining alcohol of middle solution is 70%.
8. method according to claim 6 is characterized in that: above-mentioned steps 1. in employed concentration of ethanol be 70%～80%.
9. method according to claim 8 is characterized in that: above-mentioned steps 1. in employed concentration of ethanol be 75%.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB200510072336XA CN100396299C (en) | 2005-05-30 | 2005-05-30 | Medication for treating astriction, and preparation method |
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| CNB200510072336XA CN100396299C (en) | 2005-05-30 | 2005-05-30 | Medication for treating astriction, and preparation method |
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| US9144590B2 (en) * | 2010-12-23 | 2015-09-29 | Medical And Pharmaceutical Industry Technology And Development Center | Use of aster extract in the treatment of opioid-induced constipation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1362169A (en) * | 2001-01-02 | 2002-08-07 | 杨孟君 | Nano piles treating medicine and its preparation |
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| CN1362169A (en) * | 2001-01-02 | 2002-08-07 | 杨孟君 | Nano piles treating medicine and its preparation |
Non-Patent Citations (2)
| Title |
|---|
| 中药成方制剂 第十七册. 247. 1998 |
| 中药成方制剂 第十七册. 247. 1998 * |
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